CN109700426B - Portable AO-OCT imaging device - Google Patents
Portable AO-OCT imaging device Download PDFInfo
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- CN109700426B CN109700426B CN201910081022.8A CN201910081022A CN109700426B CN 109700426 B CN109700426 B CN 109700426B CN 201910081022 A CN201910081022 A CN 201910081022A CN 109700426 B CN109700426 B CN 109700426B
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- 238000003384 imaging method Methods 0.000 title claims abstract description 32
- 239000000523 sample Substances 0.000 claims abstract description 50
- 239000013307 optical fiber Substances 0.000 claims abstract description 33
- 238000001514 detection method Methods 0.000 claims abstract description 9
- 239000007788 liquid Substances 0.000 claims description 11
- 239000000835 fiber Substances 0.000 claims description 10
- 230000010287 polarization Effects 0.000 claims description 7
- 230000004075 alteration Effects 0.000 claims description 4
- 201000010099 disease Diseases 0.000 abstract description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 3
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- 238000000034 method Methods 0.000 abstract description 3
- 230000008569 process Effects 0.000 abstract description 3
- 238000007689 inspection Methods 0.000 abstract 1
- 238000012014 optical coherence tomography Methods 0.000 description 15
- 210000004027 cell Anatomy 0.000 description 5
- 230000003287 optical effect Effects 0.000 description 3
- 206010064930 age-related macular degeneration Diseases 0.000 description 2
- 208000002780 macular degeneration Diseases 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
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- 210000000964 retinal cone photoreceptor cell Anatomy 0.000 description 2
- 230000002207 retinal effect Effects 0.000 description 2
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- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 description 1
- 208000017442 Retinal disease Diseases 0.000 description 1
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- 210000002919 epithelial cell Anatomy 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000012634 optical imaging Methods 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000010349 pulsation Effects 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 230000004232 retinal microvasculature Effects 0.000 description 1
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- 210000000880 retinal rod photoreceptor cell Anatomy 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
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- Investigating Or Analysing Materials By Optical Means (AREA)
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Abstract
The invention provides a portable AO-OCT imaging device, which comprises a box body and a handheld probe, wherein the box body is connected with the handheld probe through an optical fiber; a light source, an optical fiber coupler, a reference arm, a sample arm and a spectrometer are arranged in the box body and are in optical fiber connection with each other; the sample arm comprises a wavefront sensor, a spectroscope and a deformable mirror, and a flow detection scanner is arranged in the handheld probe and used for scanning and detecting an object to be imaged; the device is through integrating, is in the same place the partial lens integration that is close to the human eye in the scanning and makes handheld probe, realizes handheld function, and other parts are integrated in the box, portable, convenient operation also can improve the comfort level of disease to the inspection to better service infant. The device has the advantages of friendly imaging process, no invasiveness, short time consumption and high imaging resolution, enables doctors to rapidly and accurately analyze the illness state, has low cost, is hopeful to be industrialized, and becomes a standard detection tool for medical staff in ophthalmology.
Description
Technical Field
The invention belongs to the technical field of optical imaging, and particularly relates to a portable AO-OCT imaging device.
Background
Optical Coherence Tomography (OCT) has become an important tool for detecting retinal diseases. However, the underlying mechanisms of diseases such as age-related macular degeneration (AMD) or diabetic statin are still unknown. To gain a better understanding of the pathogenesis of these diseases, information on the retinal cell level needs to be detected in vivo.
Current commercial OCT instruments lack sufficient lateral resolution for cell imaging, so imaging at the cellular level is limited and single cells, such as cone photoreceptors, can only be seen in healthy human eyes under specific conditions. To overcome this limitation, adaptive Optics (AO) are often combined with OCT, which essentially increases the lateral resolution of optical retinal imaging, and the high collection efficiency provided by AO-assisted devices has increased vascular contrast compared to standard OCT imaging, can correct for chromatic aberration of the eye, and increases the resolution of retinal microvasculature under existing clinical imaging capabilities. AO-OCT can show various cell types in the retina, such as cone photoreceptors, rod photoreceptors, retinal pigment epithelial cells, erythrocytes, and even ganglion cells. However, a particularly challenging problem in converting these devices into diagnostic instruments is the considerable volume of the instrument, which takes up a lot of space.
Disclosure of Invention
It is an object of the present invention to provide a portable AO-OCT imaging device mainly for infants, as infants may be more difficult to examine the eyes.
In order to achieve the technical purpose, the technical scheme of the invention is as follows: the portable AO-OCT imaging device comprises a box body and a handheld probe, wherein the box body is connected with the handheld probe through an optical fiber;
a light source, an optical fiber coupler, a reference arm, a sample arm and a spectrometer are arranged in the box body and are in optical fiber connection with each other; the sample arm comprises a wavefront sensor, a spectroscope and a deformable mirror, and a flow detection scanner is arranged in the handheld probe and used for scanning and detecting an object to be imaged;
light emitted by the light source is split by the optical fiber coupler and then enters the reference arm and the sample arm respectively, wherein after the light entering the sample arm reaches the spectroscope, a small part of the light passes through the spectroscope and reaches the wavefront sensor; most of the light is reflected by the spectroscope, then is transmitted to the deformable mirror, enters the handheld probe through reflection conduction, is scanned by the flow detection scanner to a detection target, the scanned light is reflected back, returns to the original path to enter the sample arm, is divided into two parts again when reaching the spectroscope, and one part of the light penetrates through the spectroscope and enters the wavefront sensor to detect the wavefront aberration of the returned light so as to calibrate the deformable mirror; and the other part of the light is reflected by the spectroscope and enters the optical fiber coupler, and finally, the light reflected by the sample arm and the reference arm enters the optical fiber coupler to interfere to form interference light, and the interference light is received and imaged by the spectrometer.
The light source is usually light in the near infrared band, preferably with a wavelength of 750nm-850nm, which is more advantageous for imaging.
The fiber coupler is mainly used for light splitting, preferably the fiber coupler is a 50/50 fiber coupler so as to obtain better interference signals.
The reference arm is preferably composed of a first focusing lens, a liquid lens, a sighting telescope and a first reflecting mirror, and the incoming light beam sequentially passes through the first focusing lens, the liquid lens and the sighting telescope, is focused on the first reflecting mirror to be reflected, and then returns to the optical fiber coupler in the original path. The use of a liquid lens allows the focal length to be varied by varying the curvature of the liquid, thereby accommodating different eye lengths.
Preferably, the sample arm further comprises a second focusing lens, a second reflecting mirror, a third reflecting mirror, a second collimating lens, a third collimating lens, a fourth reflecting mirror and a first collimator, wherein the light entering the sample arm passes through the second focusing lens, then reaches the second reflecting mirror to be reflected and then reaches the spectroscope, wherein a part of the light passes through the spectroscope to be reflected and sequentially enters the second collimating lens, the third collimating lens and then reaches the deformable mirror, passes through the deformable mirror to be reflected and enters the first collimator through the fourth reflecting mirror and then enters the handheld part through the optical fiber; the other part is reflected by the spectroscope through the third reflecting mirror to reach the wavefront sensor.
Preferably, the handheld probe comprises a second collimator, a fourth focusing lens, a galvanometer scanner, a fifth reflecting mirror and a fifth focusing lens, wherein an incoming light beam is collimated by the second collimator, focused by the fourth focusing lens to the galvanometer scanner, reflected by the fifth reflecting mirror to enter the fifth focusing mirror, and focused by the fifth focusing mirror to a sample to be measured.
Preferably, the spectrometer comprises a first collimating lens, a grating, a third focusing lens and a camera, wherein the interference light is collimated by the first collimating lens and then split by the grating according to wavelength, and is focused to the camera for imaging through the third focusing lens.
Preferably, polarization controllers are further arranged between the optical fiber coupler and the reference arm, between the optical fiber coupler and the sample arm and between the optical fiber coupler and the spectrometer respectively, so that the polarization states of all light paths can be controlled better, and the consistency of signals is ensured.
The portable AO-OCT imaging device provided by the invention integrates partial lenses close to eyes in scanning to be made into the handheld probe through integration, so that the handheld function is realized, the rest parts are integrated in the box body, the portable AO-OCT imaging device is convenient to carry and operate, and the comfort level of patients on examination can be improved, so that the infant can be better served.
Drawings
Fig. 1 is a schematic structural diagram of an optical coherence tomography device for measuring eye pulsation according to embodiment 1 of the present invention.
Detailed Description
The technical scheme of the invention is described in detail below with reference to the accompanying drawings and specific embodiments.
Example 1
Referring to fig. 1, a portable AO-OCT imaging apparatus includes a case 1 and a hand-held probe 2, and the case 1 and the hand-held probe 2 are connected by an optical fiber.
The box 1 is internally provided with a light source 3, an optical fiber coupler 4, a reference arm, a sample arm and a spectrometer which are connected with each other through optical fibers. The wavelength of the light source 3 is 750nm-850nm, and the optical fiber coupler 4 is a 50/50 optical fiber coupler.
The reference arm comprises a first focusing lens 5, a liquid lens 6, a collimator 7 and a first mirror 28.
The sample arm comprises a second focusing lens 8, a second reflecting mirror 9, a spectroscope 10, a third reflecting mirror 16, a wavefront sensor 17, a second collimating lens 11, a third collimating lens 12, a deformable mirror 13, a fourth reflecting mirror 14 and a first collimator 15.
The handheld probe 2 comprises a second collimator 18, a fourth focusing lens 19, a galvanometer scanner 20, a fifth mirror 21 and a fifth focusing lens 22.
The spectrometer comprises a first collimating lens 23, a grating 24, a third focusing lens 25 and a camera 26.
After entering the 50/50 fiber coupler 4, the light emitted by the light source 3 is divided into two parts, one part enters the sample arm and the other part enters the reference arm.
The light entering the reference arm forms parallel light after passing through the first focusing lens 5, then is focused to the first reflecting mirror 28 through the liquid lens 6 and the sighting telescope 7 in sequence, and is reflected by the first reflecting mirror 28 to return to enter the optical fiber coupler 4 in the original path.
The light entering the sample arm is converted into parallel light after passing through the second focusing lens 8, and then reflected by the second reflecting mirror 9 to the spectroscope 10, wherein a small part of the light passing through the spectroscope 10 is reflected by the third reflecting mirror 16 to the wavefront sensor 17; most of the light is reflected by the spectroscope 10, is focused on the deformable mirror 13 through the second collimating lens 11 and the third collimating lens 12 in sequence, is reflected on the fourth reflecting mirror 14 through the deformable mirror 13, is reflected on the first collimator 15 through the fourth reflecting mirror 14, is collimated, enters the handheld probe 2 through the optical fiber, is collimated through the second collimator 18 after entering the handheld probe, is focused on the galvanometer scanner 20 through the fourth focusing lens 19, is reflected by the galvanometer scanner 20 to reach the fifth reflecting mirror 21, is reflected by the fifth reflecting mirror 21 and is focused on the fundus to be detected through the fifth focusing lens 22, is scanned, the light after scanning is back scattered and returns along the original path, is divided into two parts again when reaching the spectroscope 10, and one part of the light enters the wavefront sensor 17 through the spectroscope 10 to detect the wavefront aberration of the returned light, and the deformable mirror 13 is calibrated; the other part is reflected by the beam splitter 10 and enters the fiber coupler 4.
Finally, the light reflected by the sample arm and the reference arm enters the optical fiber coupler 4 to interfere, so that interference light is formed, the interference light enters the spectrometer, is collimated by the first collimating lens 23, is split according to wavelength by the grating 24, and is focused to the camera 26 for imaging by the third focusing lens 25.
In order to make the polarization states of all the partial light consistent, the imaging effect is better, and polarization controllers 27 are respectively arranged between the optical fiber coupler 4 and the reference arm, between the optical fiber coupler 4 and the sample arm and between the optical fiber coupler 4 and the spectrometer.
The optical coherence tomography device provided in embodiment 1 has the following advantages:
1. through the integration, the partial lenses which are close to eyes in the scanning process are integrated together to be made into the handheld probe, so that the handheld function is realized, the rest parts are integrated in the box body, the portable and compact type infant care device is more compact and portable and convenient to operate, and the comfort level of patients on examination can be improved, so that the infant care device is better used for infant care.
2. During imaging, a beam splitter 10 is placed before the wavefront sensor 16 in the sample arm, and can split light to perform wavefront measurement, and correct imaging, so that imaging resolution is higher.
3. The reference arm uses a liquid lens 6, and the liquid lens can be adjusted to adapt to different eye lengths by using the variable focal length characteristic of the liquid lens.
4. A polarization controller 27 is disposed on each of the branch optical paths, so that the polarization states of the optical paths are consistent, and the imaging signals are more stable.
5. The device has the advantages of friendly imaging process, no invasiveness, short time consumption and high imaging resolution, enables doctors to rapidly and accurately analyze the illness state, has low cost, is hopeful to be industrialized, and becomes a standard detection tool for medical staff in ophthalmology.
Variations and modifications to the above would be obvious to persons skilled in the art to which the invention pertains from the foregoing description and teachings. Therefore, the invention is not limited to the specific embodiments disclosed and described above, but some modifications and changes of the invention should be also included in the scope of the claims of the invention. In addition, although specific terms are used in the present specification, these terms are for convenience of description only and do not limit the present invention in any way.
Claims (5)
1. The portable AO-OCT imaging device is characterized by comprising a box body and a handheld probe, wherein the box body is connected with the handheld probe through an optical fiber; a light source, an optical fiber coupler, a reference arm, a sample arm and a spectrometer are arranged in the box body and are in optical fiber connection with each other; the sample arm comprises a wavefront sensor, a spectroscope and a deformable mirror, and a flow detection scanner is arranged in the handheld probe and used for scanning and detecting an object to be imaged; light emitted by the light source is split by the optical fiber coupler and then enters the reference arm and the sample arm respectively, wherein after the light entering the sample arm reaches the spectroscope, a small part of the light passes through the spectroscope and reaches the wavefront sensor; most of the light is reflected by the spectroscope, then is transmitted to the deformable mirror, enters the handheld probe through reflection conduction, is scanned by the flow detection scanner to a detection target, the scanned light is reflected back, returns to the original path to enter the sample arm, is divided into two parts again when reaching the spectroscope, and one part of the light penetrates through the spectroscope and enters the wavefront sensor to detect the wavefront aberration of the returned light so as to calibrate the deformable mirror; the other part is reflected by the spectroscope and enters the optical fiber coupler, and finally, the light reflected by the sample arm and the reference arm enters the optical fiber coupler and then is interfered to form interference light, and the interference light is received and imaged by the spectrometer;
the reference arm comprises a first focusing lens, a liquid lens, a sighting telescope and a first reflecting mirror, and an incoming light beam sequentially passes through the first focusing lens, the liquid lens and the sighting telescope, is focused on the first reflecting mirror to be reflected, and then returns to the optical fiber coupler in a primary path;
the sample arm also comprises a second focusing lens, a second reflecting mirror, a third reflecting mirror, a second collimating lens, a third collimating lens, a fourth reflecting mirror and a first collimator, wherein light entering the sample arm is reflected by the second focusing lens, then reaches a spectroscope, wherein a part of the light is reflected by the spectroscope, sequentially enters the second collimating lens and the third collimating lens, then reaches a deformable mirror, is reflected by the fourth reflecting mirror after passing through the deformable mirror, enters the first collimator, and then enters the handheld part through an optical fiber; the other part of the light passes through the spectroscope and is reflected by the third reflecting mirror to reach the wavefront sensor;
the handheld probe comprises a second collimator, a fourth focusing lens, a galvanometer scanner, a fifth reflecting mirror and a fifth focusing lens, wherein an incoming light beam is collimated by the second collimator, focused by the fourth focusing lens to the galvanometer scanner, reflected by the fifth reflecting mirror, enters the fifth focusing mirror, and focused by the fifth focusing mirror to a sample to be detected.
2. The portable AO-OCT imaging device of claim 1, wherein the light source has a wavelength of 750nm-850nm.
3. The portable AO-OCT imaging device of claim 1, wherein the fiber coupler is a 50/50 fiber coupler.
4. The portable AO-OCT imaging apparatus of claim 1, wherein the spectrometer comprises a first collimating lens, a grating, a third focusing lens, and a camera, wherein the interference light is collimated by the first collimating lens, split by the grating according to wavelength, and focused by the third focusing lens to the camera for imaging.
5. The portable AO-OCT imaging apparatus of claim 1, wherein polarization controllers are further disposed between the fiber coupler and the reference arm, between the fiber coupler and the sample arm, and between the fiber coupler and the spectrometer, respectively.
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| CN201910081022.8A CN109700426B (en) | 2019-01-28 | 2019-01-28 | Portable AO-OCT imaging device |
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| CN201910081022.8A CN109700426B (en) | 2019-01-28 | 2019-01-28 | Portable AO-OCT imaging device |
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| CN111627085B (en) * | 2020-06-01 | 2023-05-05 | 中国科学院长春光学精密机械与物理研究所 | Wavefront split-field curvature sensing method and device and self-adaptive OCT system |
| CN112155510A (en) * | 2020-09-30 | 2021-01-01 | 广东唯仁医疗科技有限公司 | Portable adaptive optics OCTA imaging system based on middle numerical aperture |
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| CN201019719Y (en) * | 2007-03-29 | 2008-02-13 | 浙江大学 | Spectrum region OCT endoscopic image pick-up device used for in situ optical biopsy |
| CN101869466A (en) * | 2010-07-13 | 2010-10-27 | 李超宏 | Confocal scanning and optical coherence tomograph based on self-adaptive optical technology |
| CN103799975A (en) * | 2014-02-26 | 2014-05-21 | 中国科学院光电技术研究所 | Adaptive-optics OCT retina imager using coherence-gated wavefront sensor |
| CN108523839A (en) * | 2018-04-17 | 2018-09-14 | 中国科学院苏州生物医学工程技术研究所 | Hand-held line is confocal with optical coherence tomography fundus imaging instrument |
| CN209915944U (en) * | 2019-01-28 | 2020-01-10 | 广东唯仁医疗科技有限公司 | Portable AO-OCT imaging device |
-
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- 2019-01-28 CN CN201910081022.8A patent/CN109700426B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201019719Y (en) * | 2007-03-29 | 2008-02-13 | 浙江大学 | Spectrum region OCT endoscopic image pick-up device used for in situ optical biopsy |
| CN101869466A (en) * | 2010-07-13 | 2010-10-27 | 李超宏 | Confocal scanning and optical coherence tomograph based on self-adaptive optical technology |
| CN103799975A (en) * | 2014-02-26 | 2014-05-21 | 中国科学院光电技术研究所 | Adaptive-optics OCT retina imager using coherence-gated wavefront sensor |
| CN108523839A (en) * | 2018-04-17 | 2018-09-14 | 中国科学院苏州生物医学工程技术研究所 | Hand-held line is confocal with optical coherence tomography fundus imaging instrument |
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