CN109077698A - A kind of reversible preposition scanning optoacoustic microlaparoscopy - Google Patents

A kind of reversible preposition scanning optoacoustic microlaparoscopy Download PDF

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Publication number
CN109077698A
CN109077698A CN201810695074.XA CN201810695074A CN109077698A CN 109077698 A CN109077698 A CN 109077698A CN 201810695074 A CN201810695074 A CN 201810695074A CN 109077698 A CN109077698 A CN 109077698A
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Prior art keywords
mirror
reversible
ultrasonic transducer
coupler
optoacoustic
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CN201810695074.XA
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CN109077698B (en
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杨思华
陆畅
熊科迪
邢达
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South China Normal University
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South China Normal University
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/313Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for introducing through surgical openings, e.g. laparoscopes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163Optical arrangements
    • A61B1/00174Optical arrangements characterised by the viewing angles
    • A61B1/00183Optical arrangements characterised by the viewing angles for variable viewing angles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/005Flexible endoscopes
    • A61B1/0051Flexible endoscopes with controlled bending of insertion part
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0093Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
    • A61B5/0095Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/12Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/44Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
    • A61B8/4483Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer

Abstract

The invention discloses a kind of reversible preposition scanning optoacoustic microlaparoscopy, which includes the probe segment that front end is arranged in, the snake bone sleeve portion that centre is arranged in, the operation control portion point that rear end is arranged in;Wherein front-end probe part includes coupler, hollow ultrasonic transducer, MEMS Scan mirror, focal length non-spherical lens, metallic-membrane plating reflector, C lens, optical fiber, micro-optical camera and signal wire;Intermediate snake bone sleeve portion includes its internal seal wire;Back-end operations control section includes control handle, handle.The reversible scan forward optoacoustic laparoscope in front end of the invention both can provide the surface optical reflective information of detection position by scan forward photoacoustic imaging in conjunction with optical imagery, also can provide tissue deep layer light absorption structural information.Reversible front-end probe realizes different observation visual angles, is conducive to that intraperitoneal local organization is accurately positioned to obtain multi-faceted, multi-level physical parameter and image information.

Description

A kind of reversible preposition scanning optoacoustic microlaparoscopy
Technical field
The invention belongs to laparoscope photo-acoustic detection technical field of imaging, and in particular to a kind of reversible preposition scanning optoacoustic Microlaparoscopy.
Background technique
Currently, existing laparoscope is a straight hard tube in the market, provide illumination using cold light source, miniature webcam into Row imaging.Laparoscopic surgery is an invasive methods, is an inexorable trend of the following operation method development.Therefore laparoscope Using there is very important effect.
Existing method carries out laparoscopic surgery and experienced doctor is needed to differentiate normal tissue and lesion group by naked eyes It knits, even more subtle lesion.The image that doctor needs to observe organ different angle judges, rigid long straight tube is obviously not It is to be easy to operate.With the popularization and application of laparoscope medically, many past open operations are now by intracavitary hand Art replaces, and more refines, and rationalizes, the laparoscope design and manufacture of accuracy, it appears particularly important.
The advantages of photoacoustic imaging combination optical imagery and acoustics imaging, realizes high contrast and high-penetration degree, is a kind of Novel lossless imaging technique.When pulsed laser irradiation is into tissue, the light absorption domain of tissue will generate photoacoustic signal, carry The light absorption characteristics information of tissue can reconstruct the light absorption distributed image in tissue by detecting photoacoustic signal.When guarantee into Under the premise of the uniformity for penetrating light, optoacoustic reconstruction image and absorption distribution have one-to-one relationship.
The application number patent application of application number 201410104887.9 discloses a kind of ultrasonic face for laparoscopic surgery Battle array probe, the mode of connection connected entirely from backing using flexible circuit board provide guarantor for the miniaturization of more array element ultrasonic devices Barrier, meets the needs of laparoscopic surgery, but since the contrast of ultrasound image is low, still will appear fail to pinpoint a disease in diagnosis, mistaken diagnosis, therefore light The high contrast of acoustic imaging is expected to that the deficiency of ultrasonic imaging can be made up;The patent application publication of application number 201710165093.7 A kind of optoacoustic laparoscopic apparatus and its method detecting elasticity and viscosity simultaneously, the device carry out two-dimensional opto-acoustic using MEMS and sweep It retouches, high-resolution tissue elasticity and sticky quantitative measurment and imaging, but lateral scanning imagery can only be carried out, it can not be with camera shooting Head is imaged simultaneously, and object and detector to be imaged require to immerse in the coupling liquid of coupler, inconvenient, reality during surgery Poor with property, casing still uses traditional hard sleeve, cannot flexibly observe the state that detection group is woven in different directions;Application number 201711122120.9 a kind of optoacoustic endoscopy microscopic imaging device and its imaging side based on MEMS micromirror of patent application publication Method uses the anti-sound bracket of light transmission in the device and is laterally scanned, is suitable for the imaging of cavity duct wall, before being not particularly suited for To the laparoscope system of scanning;A kind of forward sight Photoacoustic endoscope of the patent application publication of application number 201210186582.8, sweeps It retouches control system and mainly passes through the single mode optical fiber made in conduit of PZT scan module control and do Surface scan, need machinery physically Movement, and motor volume is also larger, may be implemented more precisely and faster to scan not as good as using MEMS micromirror.
Summary of the invention
The shortcomings that it is a primary object of the present invention to overcome the prior art and deficiency provide a kind of reversible preposition scanning Optoacoustic microlaparoscopy, the laparoscopic procedure is easy, and coupler, which is attached to object under test surface, can carry out photo-acoustic detection, forward direction The photoacoustic imaging of scanning can be used in combination with camera, confocal imaging, obtain intraperitoneal specific tissue surface information and The physical parameter of certain depth.
In order to achieve the above object, the invention adopts the following technical scheme:
The reversible preposition scanning optoacoustic microlaparoscopy of one kind provided by the invention, the probe portion including front end is arranged in Point, intermediate snake bone sleeve portion is set and the operation control portion point three parts of rear end are set;
The probe segment include coupler, hollow ultrasonic transducer, MEMS Scan mirror, focal length non-spherical lens, Metallic-membrane plating reflector, C lens, optical fiber, micro-optical camera and signal wire;The coupler, hollow ultrasonic transducer, MEMS bis- It ties up scanning mirror and is close to place according to the same axle center, the casing of hollow ultrasonic transducer makes inside it in the tail end of coupler Hollow ultrasonic transducer is close to coupler, and the shell of ultrasonic transducer is placed in probing shell front end, and bottom fixation fits in It pops one's head in the reserved plane of inner sidewall;MEMS Scan mirror, focal length non-spherical lens, metallic-membrane plating reflector coaxial placement, make from The light that metallic-membrane plating reflector reflects beats the mirror surface in MEMS Scan mirror just by the center of focal length non-spherical lens On;Metallic-membrane plating reflector, C lens, optical fiber are close to place according to the same axle center, and the metallic-membrane plating reflector back side is fixed on MEMS two dimension and sweeps It retouches in the plane right above mirror, C lens are placed in pre-designed circular groove, and optical fiber is placed in thereafter;
The snake bone sleeve portion includes snake bone, casing and its internal seal wire, drives snake cyrtosis by seal wire, covers effective In protection snake bone;
The back-end operations control section includes control button and handle, and the control handle, handle are mounted in laparoscope On the outside of tube wall.
The coupler is the column made by Poly material, colorless and transparent, outer end as a preferred technical solution, It is processed as arc, radius of curvature is equal to coupler outermost end to the distance at hollow ultrasonic transducer center;The coupler table Polishing treatment, prominent probing shell are passed through in face.
It is 20MHz that the hollow ultrasonic transducer, which receives the dominant frequency of ultrasonic signal, as a preferred technical solution, outside Diameter 7mm, internal diameter 2mm, the outer diameter of hollow ultrasonic transducer are equal to the cross-sectional diameter of coupler, and coupler is close to ultrasonic transduction Device is placed, convenient for receiving ultrasonic signal and transmitting.
The mirror surface of the MEMS Scan mirror is under the driving of triangle wave voltage to X as a preferred technical solution, Axis, the deflection of Y-axis rule make light beam measuring targets carry out two-dimensional scanning, MEMS Scan mirror 2 × 2mm of chip size, mirror Face diameter 1mm is fixed among the inclined-plane at 45 degree of pre-designed inclination angles, the backing face of mirror surface and hollow ultrasonic transducer At 45 degree of angles, the center of circle of mirror surface and the center of circle of hollow energy converter clear aperature are coaxial.
Focal length non-spherical lens the diameter 6mm, focal length 24.2mm are fixed on MEMS as a preferred technical solution, Right above Scan mirror, the lens center of circle and MEMS mirror face are just opposite;The light beam of collimation passes through focal length non-spherical lens back focal length Increase, the effective area of light beam scanning increases, by MEMS Scan mirror, hollow ultrasonic transducer, coupler, the light of focusing Beam measuring targets two-dimensional scanning.
The metallic-membrane plating reflector is that the inclined-plane of prism is plated to high deielectric-coating as a preferred technical solution, corresponding phase Answer the laser of wavelength that there is high optical reflectance, reflectivity is greater than 95%, the bottom surface of metallic-membrane plating reflector is fixed on probe inner sidewall Plane on, by the center of the center of reflecting mirror alignment focal length non-spherical lens.
The C lens are used to collimate or focus the light beam transmitted from optical fiber as a preferred technical solution, straight Diameter 1mm, focal length 2mm, length 5mm, C lens converge to light beam on reflecting mirror, and reflecting mirror reflects the light onto focal length aspheric again Face lens, then through MEMS Scan mirror, light beam passes through hollow ultrasonic transducer and carries out raster scanning.
The micro-optical camera diameter 3mm as a preferred technical solution, has the good depth of field 3- 100mm, 120 degree of biggish field angle come with LED cold light illumination light source, and micro-optical camera is fixed on above coupler Groove in, prominent probing shell is convenient for optical imagery.
The snake bone casing is bent towards different directions respectively by the traction of seal wire as a preferred technical solution,.
There are two runner handles for the control handle as a preferred technical solution, and it is curved to control optoacoustic laparoscope respectively Bent direction and angle.
Compared with the prior art, the invention has the following advantages and beneficial effects:
(1) the reversible preposition scanning optoacoustic microlaparoscopy of one kind of the invention, is attached to tissue surface for coupling unit Can be detected, the photoacoustic imaging of scan forward is used in combination with camera optical imagery, select camera optical imagery by compared with Big field angle obtains the large-scale surface information of intraperitoneal detected part, and the suspicious or sense found in this visual field is emerging The position of interest, then select the photoacoustic imaging of scan forward to carry out careful micro-imaging, and the light that can not only obtain tissue surface is inhaled Receive distributed image, moreover it is possible to obtain the organizational information of certain depth.Can tuning formula front end can it is intraperitoneal it is flexible realization not Same observation visual angle, is conducive to that intraperitoneal specific tissue is accurately positioned, to obtain multi-faceted, multi-level physical parameter And image information.
(2) it generally illuminates and is imaged using single mirror in laparoscopic surgery, this needs experienced doctor careful Observation increases the accuracy to spots localization to be measured and judgement so popping one's head on the basis of single mirror plus photoacoustic imaging, While optical camera detects large-scale tissue surface information, Suspected Area is determined, it is available using photoacoustic imaging The organizational information of certain depth carries out subtle detection, further determines that specific tissue;It is supervised in real time during surgery when desired Survey the status information of tissue, it is clear that the long tube of hard can easily not obtain the image of tissue different directions, different angle, institute Added a bit of snake bone casing, the curved direction in control front end and angular dimension are operated by handle, it is more flexible to realize Richer more careful micro- imaging.
Detailed description of the invention
Fig. 1 is reversible preposition scanning optoacoustic microlaparoscopy structural schematic diagram;
Fig. 2 is reversible preposition scanning optoacoustic microlaparoscopy bending state structural schematic diagram;
Fig. 3 is the front end the schematic diagram of the section structure equipped with scan forward optoacoustic probe and optical camera of embodiment 1;
Fig. 4 is the front-end block schematic diagram equipped with scan forward optoacoustic probe and optical camera of embodiment 1.
Drawing reference numeral explanation: 1, preposition scanning optoacoustic microlaparoscopy;1-1, probe segment;1-2, snake bone casing;1-3, Operation control portion point;2, coupler;3, hollow ultrasonic transducer;4, MEMS Scan mirror;5, focal length non-spherical lens;6, it plates Film reflecting mirror;7, C lens;8, the first control handle;9, the second control handle;10, micro-optical camera;11, first handle; 12, second handle;13, single mode optical fiber;14, ultrasonic transducer shell.
Specific embodiment
Present invention will now be described in further detail with reference to the embodiments and the accompanying drawings, but embodiments of the present invention are unlimited In this.
Embodiment 1
As shown in Fig.1 and Fig.2, a kind of reversible preposition scanning optoacoustic microlaparoscopy 1, the spy including front end is arranged in The operation control portion that head divides 1-1, intermediate snake bone sleeve portion 1-2 is arranged in and rear end is arranged in divides 1-3 three parts;This hair The reversible scan forward optoacoustic laparoscope in bright front end both can provide inspection by scan forward photoacoustic imaging in conjunction with optical imagery The surface optical reflective information for surveying position, also can provide tissue deep layer light absorption structural information.Reversible front-end probe is realized Different observation visual angles, be conducive to be accurately positioned intraperitoneal local organization to obtain multi-faceted, multi-level physical parameter and Image information.Wherein reversible finger pulp s hysteroscope front-end probe can be adjusted vertically in four-way bending in left and right, direction, bending angle Regulated and controled by control handle.
As shown in Figure 3, Figure 4, the probe segment includes coupler 2, hollow ultrasonic transducer 3, MEMS Scan mirror 4, focal length non-spherical lens 5, metallic-membrane plating reflector 6, C lens 7, single mode optical fiber 13, micro-optical camera 10, outside ultrasonic transducer Shell 14;On the coupler of the 13 1 end Jie pulse laser of single mode optical fiber, the other end is fixed on 6 front end of C lens, and light beam is logical The transmitting of single mode optical fiber 13 is crossed through 7 collimation focusing of C lens, distance is calculated and focus is reached just at metallic-membrane plating reflector 6, is plated Film reflecting mirror 6 can reflect greater than 99% light beam, and the light beam by reflection reaches focal length non-spherical lens 5, and focal length increases to 24mm, by MEMS Scan mirror 4, as the deflection of reflecting mirror is swung, light beam is worn from the aperture of hollow ultrasonic transducer 3 Past carries out two-dimensional scanning to tissue.
As shown in Figure 3, Figure 4, the coupler, hollow ultrasonic transducer, MEMS Scan mirror are according to the same axle center It is close to place, the casing of hollow ultrasonic transducer makes its inner hollow ultrasonic transducer and coupler in the tail end of coupler It is close to, the shell of ultrasonic transducer is placed in probing shell front end, and bottom is fixed to be fitted in the reserved plane of probe inner sidewall; MEMS Scan mirror, focal length non-spherical lens, metallic-membrane plating reflector coaxial placement, make the light reflected from metallic-membrane plating reflector just The center for passing through focal length non-spherical lens well, beats on the mirror surface of MEMS Scan mirror;Metallic-membrane plating reflector, C lens, optical fiber are pressed It is close to place according to the same axle center, the metallic-membrane plating reflector back side is fixed in the plane right above MEMS Scan mirror, C lens It is placed in pre-designed circular groove, optical fiber is placed in thereafter
In the present embodiment, the coupler is the column made by Poly (styrene) material, colorless and transparent, tool There are good light transmission, sound transparency, outer end is processed as arc, is used for Acoustic focusing, and radius of curvature is equal to coupler outermost end and arrives Area for sound,focal can be located in surface of ultrasonic transducer at this time, make collected optoacoustic by the distance at hollow ultrasonic transducer center Signal is more acurrate.Polishing treatment, prominent probing shell 5mm, it can effectively increase the photoacoustic imaging visual field are passed through in coupler surface Range, and the effective field of view of optical imagery will not be stopped.
The dominant frequency that the hollow ultrasonic transducer receives ultrasonic signal is 20MHz, outer diameter 7mm, internal diameter 2mm, hollow super The outer diameter of sonic transducer is equal to the cross-sectional diameter of coupler, and coupler is close to ultrasonic transducer placement, convenient for receiving ultrasound Signal simultaneously transmits.
The MEMS Scan mirror can carry out raster scanning, MEMS Scan mirror core under the driving of sine wave 2 × 2mm of chip size, mirror surface diameter 1mm are fixed among the inclined-plane at 45 degree of pre-designed inclination angles, and mirror surface surpasses with hollow At 45 degree of angles, the center of circle of mirror surface and the center of circle of hollow energy converter clear aperature are coaxial in the backing face of sonic transducer.MEMS two dimension is swept The mirror surface of mirror is retouched under the driving of triangle wave voltage to X-axis, the deflection of Y-axis rule makes light beam measuring targets carry out two dimension and sweeps It retouches.
Focal length non-spherical lens diameter 6mm, the focal length 24.2mm is fixed on right above MEMS Scan mirror, thoroughly The mirror center of circle and MEMS mirror face are just opposite.The light beam of collimation is increased by focal length non-spherical lens back focal length, and light beam scans effective Area increases, and by MEMS Scan mirror, hollow ultrasonic transducer, coupler, the light beam measuring targets two dimension of focusing is swept It retouches.
The metallic-membrane plating reflector is that the inclined-plane of prism is plated to high deielectric-coating, and the laser of corresponding respective wavelength has bloom Reflectivity, reflectivity are greater than 95%, the bottom surface of metallic-membrane plating reflector are fixed in the plane of probe inner sidewall, will be in reflecting mirror The center of heart alignment focal length non-spherical lens.
The C lens are used to collimate or focus the light beam transmitted from optical fiber, diameter 1mm, focal length 2mm, length 5mm, C lens converge to light beam on reflecting mirror, and reflecting mirror reflects the light onto focal length non-spherical lens again, then through MEMS two dimension Scanning mirror, light beam pass through hollow ultrasonic transducer and carry out raster scanning.
The micro-optical camera diameter 3mm, have good 3-100mm of the depth of field, 120 degree of biggish field angle, LED cold light illumination light source is come with, micro-optical camera is fixed in the groove above coupler, prominent probing shell 1mm, It is convenient for optical imagery.
The snake bone casing 1-2 is flexible casing, and the snake bone sleeve portion includes that snake bone, casing and its inside are led Silk drives snake cyrtosis by seal wire, and casing is for protecting snake bone;
The back-end operations control section 1-3 includes control button and handle, and the control handle, handle are mounted in abdominal cavity On the outside of mirror tube wall;Control button includes the first control button 8, the second control button 9;Handle includes first handle 11, second-hand Handle 12, the first handle 11, second handle 12 control the curved direction of optoacoustic laparoscope and angle respectively.
Intermediate snake bone casing is controlled along the bending angle of X-axis and direction by first handle 11, the swing of first handle 11 The more big then curved angle of amplitude is also bigger, and the swing of first handle 11 upwards, downward can control positive and negative half along X-axis respectively Bending shaft, maximum bending angle are no more than 60 degree, and same second handle 12 controls bending angle and the direction of Y-axis, control Method processed is same as above.
It is received by the ultrasonic wave that pulse laser excites by coupler 2, is transmitted to hollow ultrasonic transducer 3, is converted to electricity Signal handles to obtain photoacoustic image through amplifier, data collecting card, Labview program.
Embodiment 2
With the optoacoustic laparoscope for scan forward of example 1 to the imaging method of Agar samples, include the following steps:
Vein Agar samples are first placed in 2 lower section of coupler, successively start computer system, processing system for video, pulse Laser, ultrasound pulse transmission receiver;The handle for holding flexible tuning formula scan forward optoacoustic laparoscope passes through control the One handle 11 and second handle 12 adjust the spatial position of entire scan, are first detected with micro-optical camera 10 to Agar samples Position carries out optical imagery, collects the surface layer information of detection position, obtains optical imagery.Then coupler 2 is close to agaroid Detection zone on product, starting MEMS Scan mirror 4 make probe start optical acoustic scanning and carry out data acquisition, light simultaneously After acoustical signal carries out signal amplification by signal amplifier, it is passed to computer system and carries out image procossing, obtain photoacoustic image.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment Limitation, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention, It should be equivalent substitute mode, be included within the scope of the present invention.

Claims (10)

1. a kind of reversible preposition scanning optoacoustic microlaparoscopy, which is characterized in that including be arranged in front end probe segment, The snake bone sleeve portion that centre is set and the operation control portion point three parts that rear end is set;
The probe segment includes coupler, hollow ultrasonic transducer, MEMS Scan mirror, focal length non-spherical lens, plated film Reflecting mirror, C lens, optical fiber, micro-optical camera and signal wire;The coupler, hollow ultrasonic transducer, MEMS two dimension are swept It retouches mirror and is close to place according to the same axle center, the casing of hollow ultrasonic transducer makes its inner hollow in the tail end of coupler Ultrasonic transducer is close to coupler, and the shell of ultrasonic transducer is placed in probing shell front end, and bottom fixation fits in probe In the reserved plane of inner sidewall;MEMS Scan mirror, focal length non-spherical lens, metallic-membrane plating reflector coaxial placement, make from plated film The light that reflecting mirror reflects is beaten on the mirror surface of MEMS Scan mirror just by the center of focal length non-spherical lens;Plating Film reflecting mirror, C lens, optical fiber are close to place according to the same axle center, and the metallic-membrane plating reflector back side is fixed on MEMS Scan mirror In the plane of surface, C lens are placed in pre-designed circular groove, and optical fiber is placed in thereafter;
The snake bone sleeve portion includes snake bone, casing and its internal seal wire, drives snake cyrtosis by seal wire, casing is for protecting Protect snake bone;
The back-end operations control section includes control button and handle, and the control handle, handle are mounted in laparoscope tube wall Outside.
2. a kind of reversible preposition scanning optoacoustic microlaparoscopy according to claim 1, which is characterized in that the coupling Clutch is the column made by Poly material, colorless and transparent, and outer end is processed as arc, and it is outermost that radius of curvature is equal to coupler Hold the distance at hollow ultrasonic transducer center;Polishing treatment, prominent probing shell are passed through in the coupler surface.
3. a kind of reversible preposition scanning optoacoustic microlaparoscopy according to claim 1, which is characterized in that in described The dominant frequency that empty ultrasonic transducer receives ultrasonic signal is 20MHz, outer diameter 7mm, internal diameter 2mm, the outer diameter etc. of hollow ultrasonic transducer In the cross-sectional diameter of coupler, coupler is close to ultrasonic transducer placement, convenient for receiving ultrasonic signal and transmitting.
4. a kind of reversible preposition scanning optoacoustic microlaparoscopy according to claim 1, which is characterized in that described For the mirror surface of MEMS Scan mirror to X-axis under the driving of triangle wave voltage, the deflection of Y-axis rule makes light beam measuring targets Two-dimensional scanning is carried out, MEMS Scan mirror 2 × 2mm of chip size, mirror surface diameter 1mm are fixed on pre-designed 45 degree Among the inclined-plane at inclination angle, the backing face of mirror surface and hollow ultrasonic transducer is at 45 degree of angles, the center of circle of mirror surface and hollow energy converter The center of circle of clear aperature is coaxial.
5. a kind of reversible preposition scanning optoacoustic microlaparoscopy according to claim 1, which is characterized in that the length Burnt non-spherical lens diameter 6mm, focal length 24.2mm are fixed on right above MEMS Scan mirror, the lens center of circle and MEMS mirror face It is just opposite;The light beam of collimation is increased by focal length non-spherical lens back focal length, and the effective area of light beam scanning increases, by MEMS Scan mirror, hollow ultrasonic transducer, coupler, the light beam measuring targets two-dimensional scanning of focusing.
6. a kind of reversible preposition scanning optoacoustic microlaparoscopy according to claim 1, which is characterized in that the plating Film reflecting mirror is that the inclined-plane of prism is plated to high deielectric-coating, and the laser of corresponding respective wavelength has high optical reflectance, and reflectivity is big In 95%, the bottom surface of metallic-membrane plating reflector is fixed in the plane of probe inner sidewall, the center of reflecting mirror is directed at focal length aspheric The center of face lens.
7. a kind of reversible preposition scanning optoacoustic microlaparoscopy according to claim 1, which is characterized in that the C Lens are used to collimate or focus the light beam transmitted from optical fiber, diameter 1mm, focal length 2mm, and length 5mm, C lens are by light beam It converges on reflecting mirror, reflecting mirror reflects the light onto focal length non-spherical lens again, then through MEMS Scan mirror, light beam is passed through Hollow ultrasonic transducer carries out raster scanning.
8. a kind of reversible preposition scanning optoacoustic microlaparoscopy according to claim 1, which is characterized in that described is micro- Type optical camera diameter 3mm, has good 3-100mm of the depth of field, and 120 degree of biggish field angle comes with LED cold light photograph Mingguang City source, micro-optical camera are fixed in the groove above coupler, and prominent probing shell is convenient for optical imagery.
9. a kind of reversible preposition scanning optoacoustic microlaparoscopy according to claim 1, which is characterized in that the snake Bone casing is bent towards different directions respectively by the traction of seal wire.
10. a kind of reversible preposition scanning optoacoustic microlaparoscopy according to claim 1, which is characterized in that described There are two runner handles for control handle, control the curved direction of optoacoustic laparoscope and angle respectively.
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CN111134591A (en) * 2019-12-27 2020-05-12 华南师范大学 Photoacoustic microscopic imaging pen and imaging method
WO2021090056A1 (en) * 2019-11-08 2021-05-14 Suzhou Acuvu Med Tech Co Ltd Combined ultrasound and endoscopy
US11712149B2 (en) 2018-02-14 2023-08-01 Suzhou Acuvu Medical Technology Co, Ltd. Endoscopy devices and methods of use

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