CN108938445B

CN108938445B - Anti-hair loss composition and application thereof, anti-hair loss product comprising anti-hair loss composition and preparation method

Info

Publication number: CN108938445B
Application number: CN201710390388.4A
Authority: CN
Inventors: 孙常磊; 朱丽平; 李兆颖; 王利利; 宋姣; 胡瑞连
Original assignee: Yangzhou Perfect Commodity Co ltd; Perfect China Co Ltd; Perfect Guangdong Commodity Co Ltd
Current assignee: Yangzhou Perfect Commodity Co ltd; Perfect China Co Ltd; Perfect Guangdong Commodity Co Ltd
Priority date: 2017-05-27
Filing date: 2017-05-27
Publication date: 2021-07-20
Anticipated expiration: 2037-05-27
Also published as: CN108938445A

Abstract

The invention provides an anti-hair loss composition, which comprises two raw materials of adenosine and hydrolyzed yeast protein, and has a simple formula. The adenosine and the hydrolyzed protein are used in combination, the alopecia stopping effect is remarkable, after 12 weeks of continuous use, the number of the alopecia is reduced from 13.52 +/-4.51 to 3.08 +/-1.39, the adenosine and the hydrolyzed protein are also used for growing hair, and the hair follicles on the scalp are mainly repairedAnd increasing the number of effective hair follicles to achieve the effect of hair growth, wherein the effective hair follicle density in the test area on the scalp is 50.4 +/-10.12 (per cm) after 12 weeks of continuous use²) Increased to 129.19 + -10.12 (pieces/cm)²) (ii) a Meanwhile, the combination of adenosine and the hydrolyzed protein can effectively reduce the generation of scalp scales, and the scale degree of the scalp scales is reduced from 6 points to 0 point after the scalp scales are continuously used for 12 weeks.

Description

Anti-hair loss composition and application thereof, anti-hair loss product comprising anti-hair loss composition and preparation method

Technical Field

The invention belongs to the technical field of hair care, and relates to an anti-hair loss composition, application thereof, an anti-hair loss product comprising the same and a preparation method thereof.

Background

Alopecia is divided into normal alopecia and pathological alopecia. Normal alopecia refers to hair loss during the catagen or telogen phase; pathological hair loss refers to abnormal or excessive loss of hair during the non-catagen and telogen phases. Pathological alopecia often causes baldness, alopecia areata and other phenomena, and greatly influences the health and the beauty of people. According to survey, the incidence rate of male pathological alopecia is about 50% around the world, and the incidence rate of female pathological alopecia is about 40%.

Aiming at the increasing of the population suffering from pathological alopecia, a plurality of types of anti-alopecia products appear on the market. The products can be roughly divided into three types, wherein the first type of products mainly comprises ginger extracts, and the products mainly utilize the blood activating function of the ginger extracts to promote the blood circulation of the skin of the head by the ginger extracts so as to achieve the effect of reducing alopecia; the second product is based on the theory of traditional Chinese medicine, adopts compound herbal extracts, and correspondingly produces effects of nourishing or deoiling and the like according to different formula raw materials so as to achieve the purpose of preventing alopecia, but the two anti-alopecia products have no obvious effect from the research and analysis of products on the market; the third kind of product is a refreshing oil-controlling product, which mainly uses zinc ion-containing active ingredients such as zinc gluconate or zinc sulfate, compound menthol or alcohol, and achieves the effect of reducing hair loss by inhibiting scalp grease secretion and reducing hair follicle blockage.

To this end, chinese patent document CN1878530A discloses a method and composition for hair thickening which reduces the number of hair loss mainly by strengthening the hair mass, mainly by using adenosine, adenosine-5' -phosphate and CCPA (2-chloro-N)⁶Cyclopentyladenosine), and the like, and the composition can reduce the hair loss in the non-catagen and telogen phases by thickening the hair with FGF-7 and further enhancing the hair quality to reduce the hair loss in the non-catagen and telogen phases, but the composition disclosed in the patent document can still delay the hair loss by enhancing the hair quality of the existing hair on the basis of maintaining and protecting the existing hair quantity, and cannot fundamentally solve the problem of hair loss.

Disclosure of Invention

The composition not only can delay the existing hair shedding, but also can increase the number of effective hair follicles by repairing the hair follicles on the scalp so as to play the role of hair growth, thereby fundamentally solving the problem of hair loss.

A composition for preventing alopecia comprises adenosine and hydrolyzed yeast protein.

Preferably, in the composition for preventing alopecia, the mass ratio of adenosine to the hydrolyzed yeast protein is as follows: (1-10): (1-10).

Preferably, in the anti-hair loss composition, the mass ratio of adenosine to the hydrolyzed yeast protein is 1:1, 1:2 or 2: 3.

Preferably, the composition for preventing hair loss further comprises: d-panthenol, nicotinamide, Ginseng radix extract and arginine.

Preferably, in the anti-hair loss composition, the hair loss agent comprises, in parts by weight,

1-10 parts of adenosine, 1-10 parts of hydrolyzed yeast protein, 1-30 parts of D-panthenol, 1-30 parts of nicotinamide, 1-5 parts of ginseng extract and 1-20 parts of arginine.

An anti-hair loss product comprises the anti-hair loss composition.

Preferably, in the anti-hair loss product, the anti-hair loss product comprises a hair conditioner, a shampoo, an anti-hair loss essence and a hair growing cream.

The preparation method of the anti-hair loss product is characterized by mixing the anti-hair loss composition with conventional raw materials for preparing the anti-hair loss product and preparing the anti-hair loss product according to a conventional process.

The invention relates to application of an anti-hair loss composition.

The invention relates to application of an anti-hair loss composition in the field of hair loss prevention, hair growth and/or scalp scale removal.

The technical scheme of the invention has the following advantages:

the invention provides an anti-hair loss composition, which comprises two raw materials of adenosine and hydrolyzed yeast protein, and has a simple formula. The adenosine and the hydrolyzed protein are matched for use, so that the hair loss preventing effect is remarkable, experiments prove that after the hair loss preventing agent is continuously used for 12 weeks, the hair loss number of a tester is reduced from 13.52 +/-4.51 to 3.08 +/-1.39, the hair loss preventing effect is remarkable, meanwhile, the adenosine and the hydrolyzed protein are matched for further having the remarkable hair growth effect, the hair follicle number on the scalp is mainly repaired, the effective hair follicle number is increased, and the hair growth effect is further achieved, experiments prove that after the hair loss preventing agent is continuously used for 12 weeks, the effective hair follicle density in a testing area on the scalp of the tester is 50.4 +/-10.12 (one/cm)²) Increased to 129.19 + -10.12 (pieces/cm)²) The effect is obvious;

besides the effects, the combination of adenosine and the hydrolyzed protein can effectively reduce the generation of scalp scales, and experiments prove that the scalp scale degree score of a tester is reduced from 6 points to 0 points after the tester continuously uses the scalp scales for 12 weeks;

the anti-hair loss composition provided by the invention also comprises: d-panthenol, nicotinamide, Ginseng radix extract and arginine. The raw materials are matched with adenosine and the hydrolyzed yeast protein for use, so that the dual effects of treatment and maintenance are achieved, and the effect of the product is remarkably improved.

Detailed Description

The technical solutions of the present invention will be described clearly and completely below, and it should be apparent that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention. In addition, the technical features involved in the different embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.

The hydrolyzed yeast proteins used in examples 1-13 and comparative example 1 were purchased from Ashland group, Inc. (Ashland);

the ginseng extract solutions of examples 6 to 13 and comparative example 1 are ginseng root extract solutions, which can be obtained by conventional extraction methods of plant extracts in the prior art, including, but not limited to, water extraction and alcohol extraction. For comparison, the ginseng extracts according to examples 6 to 13 and comparative example 1 of the present application are prepared by grinding ginseng roots into powder, mixing with ethanol having a volume concentration of 60% at a mass ratio of 1:10, reflux-extracting for 2 times, reflux-extracting for 1 hour each time, filtering, combining filtrates, and concentrating to obtain a ginseng extract.

The effective hair follicle in the present invention refers to a hair follicle in which hair grows.

Example 1

An anti-hair loss composition comprising: adenosine 1Kg and hydrolyzed yeast protein 10 Kg.

Example 2

An anti-hair loss composition comprising: adenosine 10Kg and hydrolyzed yeast protein 1 Kg.

Example 3

An anti-hair loss composition comprising: adenosine 5Kg and hydrolyzed yeast protein 5 Kg.

Example 4

An anti-hair loss composition comprising: adenosine 5Kg and hydrolyzed yeast protein 10 Kg.

Example 5

An anti-hair loss composition comprising: 4Kg of adenosine and 6Kg of hydrolyzed yeast protein.

Example 6

An anti-hair loss composition comprising: adenosine 1Kg, hydrolytic yeast protein 10Kg, D-panthenol 30Kg, nicotinamide 1Kg, ginseng extract 5Kg, arginine 20 Kg.

Example 7

An anti-hair loss composition comprising: adenosine 10Kg, hydrolyzed yeast protein 1Kg, D-panthenol 1Kg, nicotinamide 30Kg, ginseng extract 1Kg, arginine 1 Kg.

Example 8

An anti-hair loss composition comprising: 6Kg of adenosine, 6Kg of hydrolyzed yeast protein, 20Kg of D-panthenol, 10Kg of nicotinamide, 3Kg of ginseng extract and 10Kg of arginine.

Example 9

An anti-hair loss composition comprising: 3Kg of adenosine, 6Kg of hydrolyzed yeast protein, 15Kg of D-panthenol, 15Kg of nicotinamide, 5Kg of ginseng extract and 15Kg of arginine.

Example 10

An anti-hair loss composition comprising: 2Kg of adenosine, 3Kg of hydrolyzed yeast protein, 20Kg of D-panthenol, 25Kg of nicotinamide, 4Kg of ginseng extract and 8Kg of arginine.

Example 11

A preparation method of an anti-hair loss shampoo comprises the following steps:

(1) mixing sodium laureth sulfate, sodium lauroamphoacetate, cocamidopropyl betaine, cocamide MEA, ethylene glycol distearate, sodium isostearoyl lactylate and PEG-7 glyceryl cocoate at 75 deg.C, and stirring to obtain mixture A;

(2) adding guar gum hydroxypropyl trimethyl ammonium chloride and polyquaternium-74 into water, stirring uniformly to obtain a mixture B, adding the mixture B into the mixture A, stirring uniformly, cooling to 45 ℃, sequentially adding the carrageen crispa extract, the anti-hair loss composition described in example 9, a preservative (Germall IS-45), citric acid, sodium chloride, water and essence, stirring uniformly, cooling to room temperature, and adjusting the pH to 6.0 to obtain the anti-hair loss shampoo.

In the hair loss preventing shampoo, sodium laureth sulfate, sodium lauroamphoacetate, cocamidopropyl betaine, cocamide MEA, ethylene glycol distearate, sodium isostearoyl lactylate, PEG-7 glyceryl cocoate, water, guar hydroxypropyltrimonium chloride, polyquaternium-74, Chondrus crispus extract, the hair loss preventing composition of example 9, a preservative (Germall IS-45), citric acid, sodium chloride and essence are in the following mass ratio: 11.5: 6.3: 6.6: 1: 1.5: 0.4: 0.4: 30: 0.5: 0.15: 0.3: 1.5: 0.7: 0.5: 0.3: 0.15.

example 12

A preparation method of the hair loss prevention hair conditioner comprises the following steps:

(1) adding polyquaternium-37 into water at room temperature, and uniformly stirring to obtain a mixture A;

(2) heating the mixture A to 75 ℃, sequentially adding behenyl trimethyl ammonium chloride, isostearamide propyl dimethyl amine, cetostearyl alcohol, methyl hydroxybenzoate and citric acid, and stirring for 30min to obtain a mixture B;

(3) adding the camellia oleosa seed oil, the polydimethylsiloxane and the polydimethylsiloxane into the mixture B in sequence, and stirring for 10min at 75 ℃ to obtain a mixture D;

(4) after cooling mixture D to 45 deg.C, D-panthenol, the alopecia preventing composition described in example 8, preservative (Germall IS-45), and essence were added in this order, cooled to room temperature, and the pH was adjusted to 5.5 to obtain the alopecia preventing hair conditioner.

In the hair loss preventing hair conditioner, the mass ratio of water, polyquaternium-37, behenyltrimethylammonium chloride, isostearamidopropyldimethylamine, cetostearyl alcohol, methylparaben, citric acid, camellia seed oil, polydimethylsiloxane, D-panthenol, the hair loss preventing composition described in example 8, preservative (Germall IS-45) and essence IS as follows: 100: 0.2: 2: 1: 4.5: 0.1: 0.25: 0.5: 1: 2: 0.2: 2.5: 0.5: 0.25.

example 13

A preparation method of the hair loss preventing essence comprises the following steps:

(1) at room temperature, mixing water and acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, and stirring uniformly to obtain a mixture A;

(2) heating the mixture A to 75 ℃, sequentially adding butanediol, propylene glycol and methyl hydroxybenzoate, and stirring at 75 ℃ for 30min to obtain a mixture B;

(3) and cooling the mixture B to 45 ℃, sequentially adding the anti-hair loss composition, the preservative (Euxyl PE 9010) and the essence which are described in example 10, uniformly stirring, cooling to room temperature, and adjusting the pH value to 5.5 to obtain the anti-hair loss essence.

In the hair loss preventing essence, the mass ratio of water, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, butanediol, propanediol, methyl hydroxybenzoate, the hair loss preventing composition described in example 10, preservative (Euxyl PE 9010) and essence is as follows: 100: 0.2: 3: 3: 0.1: 1.8: 0.5: 0.05.

comparative example 1

A composition, comprising: 15Kg of D-panthenol, 15Kg of nicotinamide, 5Kg of ginseng extract and 15Kg of arginine.

Effect verification

In order to facilitate the verification of the efficacy of the anti-hair loss composition disclosed in the present invention, the anti-hair loss compositions prepared in examples 3, 4, 5, 8, 9 and 10, and the composition prepared in comparative example 1 were prepared as anti-hair loss essences, which were prepared using any one of the methods for preparing anti-hair loss essences according to the prior art, and examples 3, 4, 5, 8, 9 and 10 were prepared as anti-hair loss essences according to the following method for comparison.

The preparation method of the hair loss preventing essence comprises the following steps: mixing water, propylene glycol and butanediol according to the mass ratio of 100:3:3, and uniformly stirring to obtain a solvent; mixing the composition or the anti-hair loss composition with a solvent according to the ratio of 200:1, stirring uniformly at 45 ℃, cooling to room temperature, and adjusting the pH value to be 5.8-6.1 to obtain the anti-hair loss essence.

Hair loss prevention creams containing the hair loss prevention compositions of examples 3, 4, 5, 8, 9 and 10, numbered 1 to 6, respectively, and hair loss prevention cream containing the composition of comparative example 1, numbered 7.

1. Effective hair follicle density and anti-hair loss condition detection

1.1 test group settings:

set 8 test groups, which are numbered 1-8 respectively, and 30 testers (including 15 males and 15 females) in each group, the age is 18-60 years, wherein, the hair loss grade of the male of 30 testers selected in each group is II-IV type, and the hair loss grade of the female is I type or II type.

Grade of male pattern hair loss

Male alopecia generally starts from both sides of the forehead, gradually extends towards the top of the head, recedes towards the hairline of the forehead, or starts from the top of the head. Alopecia continues with the front hair line receding from the sides and the forehead becoming higher, forming what is commonly referred to as "high forehead". The hair gradually becomes thin and delicate, and the new hair becomes thinner and thinner, and is soft and powerless. Bald areas have smooth skin and fine vellus hairs are visible. It is usually accompanied by desquamation, except for slight itching, there are no other subjective symptoms.

Type I: normal or substantially normal hairstyle:

type II: the frontotemporal hairline moves backwards in a triangle shape, and the distance between the frontotemporal hairline and the coronal line connecting the two auditory canals can reach 2 cm;

type III: the retraction of the two temporal corners exceeds 2cm before the coronal line, and the tops are sparse;

type IV: the two temples and hairlines recede significantly, with the midforehead receding, but with intermediate density bands of hair spaced:

and V type: the frontal temporal and apical denuded areas are enlarged, during which the hair band is narrow and sparse;

type VI: horseshoe alopecia, increased lateral and posterior baldness;

type VII: in severe forms, hair loss occurs around the ear and around the occiput, except horseshoe hair loss.

Grade of female hair loss

In general, female hair loss is caused by the diffuse loss of hair at the top of the head, so that the top hair gradually becomes thin but does not completely fall off, and the progress is slow.

Grade 1 (mild): the hair in the front of the coronal region becomes thin, the hairstyle needs to be changed to cover, and the forehead hairline is complete; the second part of clinical experiments research the analysis of traditional Chinese medicine syndrome differentiation and type identification of androgenetic alopecia and hair electron microscope experimental observation;

grade 2 (medium): the hair in the front of the coronal region becomes thinner more obviously, the range of the alopecia region is enlarged, and the change of the hair style is difficult to mask;

grade 3 (heavy): the top part is completely bald or bared, but the forehead hairline is still intact

1.2 medication settings

The test groups numbered 1 to 7 used hair loss preventing essence corresponding to the numbers thereof, respectively. The test group numbered 8 was blank and used clean water. The test period was 12 weeks. During the test, all testers did not use other anti-hair loss products except the anti-hair loss essence for the test.

The using method comprises the following steps: the individuals in the test group with the numbers of 1-7 use the hair loss prevention essence once in the morning and evening, 5g of the hair loss prevention essence is taken to be placed on the finger bellies each time, the finger bellies are gently flapped, the fingers are inserted into the hair, the solution is smeared on the scalps at the hair loss positions, and the scalp is massaged for 10-15 min;

the blank group with number 8 is applied with clear water once a day, 5g of clear water is taken each time, the fingers are inserted into hair by gently patting the abdomen of the fingers, the solution is applied to the scalp of the baldness part, and the massage is carried out for 10-15 min.

1.3 effective Hair follicle Density detection results

At the head alopecia part of the tester, a detection area with the area of 5cmx5cm is selected, and the detection areas of the tester at 2 weeks, 4 weeks, 6 weeks, 8 weeks, 10 weeks and 12 weeks are photographed by a hair follicle hair analyzer. Data were analyzed using software SPSS (statistical product and service solutions) to obtain effective hair follicle density change data, with results shown in table 1.

TABLE 1 Hair follicle Density

As can be seen from table 1, the effective hair follicle density of the test person was significantly increased at week 2 after the anti-hair loss essence containing the anti-hair loss compositions of examples 3, 4, 5, 8, 9 and 10 was used, and then the effective hair follicle density was increased with the increase of the use time, thereby proving that the anti-hair loss composition disclosed by the present invention can effectively increase the number of effective hair follicles, and further proving that it has an effective hair growth effect.

1.4 alopecia-relieving effect

Collecting the number of hair loss when the tester combs, wherein the number of hair loss of the tester is collected at 0 week and 12 week after the hair loss prevention essence is used, and the method for collecting each time specifically comprises the following steps: the hair was combed on a double layer of gauze laid 1m square, and the hair attached to the gauze was collected and counted, and the results are shown in table 2.

TABLE 2 number of comb drops

As can be seen from table 2, the number of hairs lost by the test persons 12 weeks after using the anti-hair loss essences comprising the anti-hair loss compositions of examples 3, 4, 5, 8, 9 and 10 was significantly reduced compared to that before use (week 0), demonstrating that the anti-hair loss composition disclosed in the present invention is effective in preventing hair loss.

2. Scalp scale level detection

2.1 test group settings:

setting 8 groups of test groups which are respectively numbered as 1-8, wherein the age of each group of 30 testers (including 15 males and 15 females) is 18-60 years, and the scalp scale degree of each group of 30 testers is 4 according to the scalp scale scoring standard.

TABLE 3 scalp Scale score criteria (score 0-6)

Note that in Table 3, the small pieces of scalp scale mean an area of < 1mm²The scale of scalp is larger than or equal to 1mm²Scalp scales.

2.2 medication settings

The using method comprises the following steps: the test group members numbered 1-7 respectively use the hair loss prevention essence once in the morning and evening, take 20g of the hair loss prevention essence to hands each time, apply the hair loss prevention essence to the hair and scalp by adopting a hair washing mode, rub the hair and scalp by fingers for 10-15min, and then wash the hair and scalp by clear water; the blank group numbered 8 was rinsed with clean water once a day, morning and evening.

2.3 scalp Scale level test results

The subjects who used week 0 and week 12 were scored for their degree of scalp scaling according to the scalp scaling score criteria in Table 3, and the results are shown in Table 4.

TABLE 4 scalp Scale level

	The application period is 0 week	It can be used for 12 weeks
			1	6 minutes	2 is divided into
2	6 minutes	2 is divided into
			3	6 minutes	2 is divided into
4	6 minutes	2 is divided into
			5	6 minutes	0 point (min)
6	6 minutes	2 is divided into
			7	6 minutes	6 minutes
8	6 minutes	6 minutes

As can be seen from table 4, the test persons had a significant reduction in the degree of scalp scaling after 12 weeks using the anti-hair loss essences containing the anti-hair loss compositions of examples 3, 4, 5, 8, 9 and 10.

It should be understood that the above examples are only for clarity of illustration and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications therefrom are within the scope of the invention.

Claims

1. The anti-hair loss composition is characterized by comprising, by weight, 1-10 parts of adenosine, 1-10 parts of hydrolyzed yeast protein, 1-30 parts of D-panthenol, 1-30 parts of nicotinamide, 1-5 parts of a ginseng extract and 1-20 parts of arginine.

2. The alopecia preventing composition as claimed in claim 1, wherein the mass ratio of adenosine to the hydrolyzed yeast protein is: (1-10): (1-10).

3. The alopecia preventing composition according to claim 1 or 2, wherein the mass ratio of adenosine to the hydrolyzed yeast protein is 1:1, 1:2, or 2: 3.

4. An alopecia preventing product comprising the alopecia preventing composition according to any one of claims 1 to 3.

5. The alopecia prevention product of claim 4, wherein the alopecia prevention product comprises a hair conditioner, a shampoo, a hair loss prevention essence, and a hair tonic.

6. A method for preparing the alopecia preventing product according to claim 4 or 5, wherein the alopecia preventing composition according to any one of claims 1 to 3 is mixed with conventional raw materials for preparing the alopecia preventing product, and is prepared according to a conventional process.

7. Use of an anti-hair loss composition according to any one of claims 1 to 3 for the preparation of an anti-hair loss product, a hair growth product and/or a scalp desquamation product.