CN108815232A - A kind of draft antimicrobial fluid - Google Patents
A kind of draft antimicrobial fluid Download PDFInfo
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Abstract
The invention discloses the components that a kind of draft antimicrobial fluid includes following mass percent：Thymol 0.06-0.10%, caryophyllus oil 0.03-0.08%, eucalyptus oil 0.03-0.08%, wintergreen 0.03-0.08%, menthol 0.05-0.10%, 407 0.7-1.0% of poloxamer, xylitol 0.4-0.6%, edible ethanol 18.0-22.0%, flavorant 0-0.1%, it the rest is pure water, total amount 100%.Its raw material is directly extracted from natural plants, highly-safe, use process, no pathogenicity, and no anaphylaxis has no drug resistance, and can be widely applied to various people, especially old man, children and pregnant woman；And have obvious therapeutic effect to saprodontia, canker sore, gingivitis, bleeding gums, toothache, halitosis, periodontitis, sphagitis, there is obvious scavenging effect to oral peculiar smell, and use is safe, curative effect is stablized.
Description
Technical field：
The invention belongs to oral cleaning nursing article technical fields, and in particular to one kind is original with natural plant extracts
Material, mild non-stimulated, safe without toxic side effect, with antibacterial, antibacterial, analgesic and the draft antimicrobial fluid for repairing mucous membrane of mouth effect
And preparation method thereof.
Background technique：
Oral cavity is an open environment, and oral hygiene is not only related to oral health, is also related to straight with oral hygiene
Connect relevant systemic disease.Mouthwash can effectively dispel oral peculiar smell, clean oral cavity, remove the disease that the dead angles such as teeth space are bred
Bacterium, effectively control bacterial number, prevent oral inflammation and oral system disease, are that one kind of solution oral problem is maximally efficient
With convenient and fast method.Its convenient, simple, safety, the characteristic of strength antibacterial increase a kind of oral bacteria control for clinical treatment
New technology.
The oral cavity that is directed on the market resists the product of antibacterial liquid type to be broadly divided into three classes at present：1, disinfectant is main former
Material.Such as acetic acid chlorhexidine class mouthwash, hydrogen peroxide mouthwash.Such mouthwash is used for a long time, will cause oral surfaces coloring,
It is dyed using after 6 months about 50% patient teeth, about 10% patient's severe coloring, more tooth plaque deposition person coloring is more aobvious
It writes, also results in sense of taste change.2, antibiotic is primary raw material.Such as a kind of sterilize disclosed in patent CN107982123A removes mouth
Smelly mouthwash, including the careless lotus extract of metronidazole liquid, ink, Chondrus crispus extract, Herba seu Radix Cirsii Japonici, gentamicin, peppermint
Amide, vitamin B12, surfactant, flavoring agent and deionized water.The mouthwash contains metronidazole, and such gargle is used for a long time
Saliva be easy to cause gastrointestinal reaction.Metronidazole can often cause sense of taste change, dry, oral cavity metallic taste etc., and animal experiment is shown
Metronidazole has carcinogenic, mutagenesis, pregnant woman children disabling.3, plant or animal extracts are primary raw material.This kind of mouthwash
It is highly-safe due to using natural materials as raw material, it is easy to be received by user, has become the hot spot of research.Patent
A kind of Chinese herbal medicine mouthwash of novel therapeutic canker sore disclosed in CN107441003A comprising peppermint, honeysuckle, chrysanthemum,
Nard, Roots of Rosa Multiflora Thunb, holy basil, the leaf of bamboo, salt, hydrogen peroxide and water, boil by moderate heat, have clearing heat and detoxicating, thin
The effect of liver and qi.A kind of preparation method of fragrant plant mouthwash, mouthwash disclosed in patent CN107714569 will contain respectively
Have peppermint, honeysuckle and a thymic aromatic plant extract, chrysanthemum effective component extracts, Notogineng Extract, oligofructose,
Glycerol, P-hydroxybenzoic acid sodium, tea oil etc. are mixed with out a kind of fragrant plant mouthwash, safe and non-toxic, are suitble to long-term
It uses.In addition, mouthwash of the chitin extracted using in animal body as effective component, adsorbs positive and negative charge by positive charge
Principle reaches bactericidal effect, and sterilizing rate is 78% or so.
Summary of the invention：
It is an object of the invention to be prepared for it is a kind of using natural plant extracts as the draft antimicrobial fluid of effective component and its
Preparation method provides a kind of with sterilization, antibacterial, analgesic and the draft antimicrobial fluid for repairing mucous membrane of mouth effect.
To achieve the goals above, draft antimicrobial fluid of the present invention, the component including following mass percent：Moschus
Careless phenol 0.06-0.10%, caryophyllus oil 0.03-0.08%, eucalyptus oil 0.03-0.08%, wintergreen 0.03-0.08%, menthol
0.05-0.10%, poloxamer 407 0.7-1.0%, xylitol 0.4-0.6%, edible ethanol 18.0-22.0% eat perfume
Expect 0-0.1%, the rest is pure water, total amount 100%.
The preparation method of draft antimicrobial fluid of the present invention, specific preparation process are：
(1) each component is weighed according to above-mentioned mass percent, part pure water is taken to be heated to 55-60 DEG C, be slowly added to moor
Luo Shamu 407 stirs 20-30min, until poloxamer is completely dissolved, obtains component A；
(2) thymol, caryophyllus oil, eucalyptus oil, wintergreen, menthol are sequentially added into edible ethanol, are stirred to complete
Fully dissolved, as component B；
(3) xylitol, flavorant are added in the pure water of part, are stirred, until dissolution, as component C；
(4) B component, component C are successively slowly added into component A, obtain A, B and component C mixed liquor, be then added surplus
Remaining pure water, 120 mesh filter after mixing evenly, then through filling and packaging, obtain draft antimicrobial fluid.
Further, the draft antimicrobial fluid that the present embodiment is related to, further includes mustard cooking liquor, and flavorant used is common
Fruity perfume or rose and chrysanthemum extract liquid.
Further, the preparation method of the mustard cooking liquor is：Mustard is put into micro-wave oven, at 140-160 DEG C,
After baking 5-8 minutes, it is ground into dry powder, the sodium bicarbonate aqueous solution that mass concentration is 0.5-0.7%, stirring is added in mustard dry powder
Sealing storage 0.5-1 hours, are then placed in boiling in distilling apparatus after uniformly, and taking distillate cooling is mustard cooking liquor.Mustard
Last cooking liquor is added in step (4) A, B and C group mixed liquor.
Further, the preparation method of the rose and chrysanthemum extract liquid is：Rose and chrysanthemum are dried, according to 1:
It is put into Soxhlet reflux unit after 1 mass ratio mixing, and pure water is added in reflux unit, it refluxing extraction 4-6 hours, will
Obtained phegma is concentrated into the one third of volume, obtains rose and chrysanthemum extract liquid.
Effect ingredient of the invention is all from natural plants, there is the record as medicinal license in Chinese Pharmacopoeia.With
Under be associated description of the Chinese Pharmacopoeia to principle active component：
Thymol：Cidex-7 has better effect for mould.And toxicity is low, has sterilization to oral cavity mucosa, kills
Fungi effect, has anti-corrosion, local anaesthesia and analgesic activity, for oral cavity, the disinfection and sterilization of throat, dermatophyte in saprodontia chamber
Disease, actinomycosis and otitis.
Eugenol：It is usually used in dentistry anti-inflammatory, narcotic analgesic.Topical anti-inflammatory, analgesia can quickly treat toothache.
Eucalyptus oil：There is the effects of local stimulation, disinfection, anti-inflammatory；It is usually used in the treatment and prevention in oral cavity, pharyngolaryngitis.Have
Antipyretic, anti-inflammatory, antibacterial, analgesic activity of relievining asthma.
Wintergreen：Anodyne, surgical medicine, disinfection, anti-corrosion, astringent promote blood circulation, distend the blood vessels, part
Stimulation, it is antipruritic, ease pain, detumescence.
Menthol：There are antipruritic, analgesic, anti-corrosion, stimulation, anesthesia, refrigerant and anti-inflammatory effect, be used as excitants in medicine,
Skin or mucous membrane are acted on, there is refrigerant itching-relieving action.
Mustard：Mustard is for oral administration to can be used for treating vomiting, and the secretion of energy saliva stimulating and gastric juice, whets the appetite, can be pre-
Anti- decayed tooth.
The present invention has the advantages that compared with prior art：(1) raw material is directly extracted from natural plants, safety
Property high, use process, no pathogenicity, no anaphylaxis has no drug resistance, and can be widely applied to various people, especially old man, children
And pregnant woman；(2) by effective components such as natural plant extracts thymol, caryophyllus oil, eucalyptus oil, wintergreen, menthol, mustard
Rational proportion is carried out, obtaining one kind has anti-inflammatory, quickly alleviating pain, effectively stop blooding, dispel oral peculiar smell, promoting wound and oral cavity glutinous
The draft antimicrobial fluid of the multi-efficiencies such as film healing, to saprodontia, canker sore, gingivitis, bleeding gums, toothache, halitosis, periodontal
Scorching, sphagitis has obvious therapeutic effect, has obvious scavenging effect to oral peculiar smell, and use is safe, curative effect is stablized；(3) it tests
The result shows that being up to 99% to the sterilizing rate of oral bacteria, and the antibacterial duration is long；(4) by adjusting thymol, cloves
Oil, eucalyptus oil, wintergreen, menthol and edible ethanol content and proportion and preparation process, realize in lower alcohol content
Under conditions of fat-soluble effective component dissolution, the light taste of product is mild after adjustment, be easy received by user.
Specific embodiment：
The specific technical solution of the present invention is further described combined with specific embodiments below.
Embodiment 1：
The draft antimicrobial fluid that the present embodiment is related to, comprises the following components in parts by weight：Thymol 0.6kg, caryophyllus oil
0.3kg, eucalyptus oil 0.3kg, wintergreen 0.3kg, menthol 0.5kg, poloxamer 407 7.0kg, xylitol 4.0kg are eaten
Ethyl alcohol 180kg, pure water 806.9kg, flavorant 0.05kg.
The preparation method for the draft antimicrobial fluid that the present embodiment is related to, specifically includes following steps：
(1) each component is weighed according to above-mentioned mass percent, one third pure water is taken to be heated to 55-60 DEG C, slowly added
Enter poloxamer 407, stir 20-30min, until poloxamer is completely dissolved, obtains component A；
(2) thymol, caryophyllus oil, eucalyptus oil, wintergreen, menthol are sequentially added into edible ethanol, are stirred to complete
Fully dissolved, as component B；
(3) xylitol, flavorant are added in one third pure water, are stirred, until dissolution, as component C；
(4) B component, component C are successively slowly added into component A, remaining one third pure water, stirring is then added
The filtering of 120 mesh, filling after uniformly, packaging.
Through detecting, draft antimicrobial fluid manufactured in the present embodiment, to Escherichia coli, staphylococcus aureus and Candida albicans
The average bactericidal rate for acting on 2min is respectively 99.97%, 99.96% and 99.94%.
The present embodiment component content is slightly lower, and irritation is lighter, to prevent oral inflammation, dispel oral peculiar smell as main syllabus
's.Application method：Each 15ml or so, gargles 0.5-1 minutes, uses 3-4 times daily.Oral inflammation can effectively be prevented, it is long
Time keeps breath freshening.
Embodiment 2：
The draft antimicrobial fluid that the present embodiment is related to, comprises the following components in parts by weight：Thymol 0.7kg, caryophyllus oil
0.5kg, eucalyptus oil 0.5kg, wintergreen 0.5kg, menthol 0.7kg, poloxamer 407 8.5kg, xylitol 5.0kg are eaten
Ethyl alcohol 200kg, pure water 783.60kg, flavorant 0.01kg.
Its specific preparation process is the same as embodiment 1.
The application method of the present embodiment：Each 15-20ml gargles 1-2 minutes, 5-6 times daily, is mainly used for oral cavity and bursts
The treatment of the oral inflammations such as ulcer, gingivitis, bleeding gums resists the antibacterial time that can reach 2-3 hours, relative to embodiment 1, taste
Slightly heavy, irritation is slightly strong.Women and children etc. withstand forces weak people to stimulation, can convert a small amount of pure water with liquid of the invention
(3/4 volume mouthwash adds 1/4 volume pure water) uses.
Embodiment 3：
The draft antimicrobial fluid that the present embodiment is related to, comprises the following components in parts by weight：Thymol 0.9kg, caryophyllus oil
0.7kg, eucalyptus oil 0.8kg, wintergreen 0.8kg, menthol 0.8kg, poloxamer 4070.95kg, xylitol 5.0kg are eaten
Ethyl alcohol 220kg, pure water 770.05kg, flavorant 0.05kg.
Its specific preparation process is the same as embodiment 1.
The application method of the present embodiment：Each 15-20ml gargles 1-3 minutes, 5-6 times daily, or uses as needed.
The present embodiment is higher relative to the concentration of embodiment 1,2, and irritation is also bigger, resists the antibacterial time up to 2-4 hours.
It is mainly used for more serious (such as after the tumour patient chemicotherapy) canker sore of symptom, gingivitis, bleeding gums oral inflammation
Treatment.In addition to there is higher anti-bacteriostasis rate, analgesic effect is also become apparent from.
Embodiment 4：
The draft antimicrobial fluid that the present embodiment is related to, the component including following mass percent：Thymol 1kg, caryophyllus oil
0.8kg, eucalyptus oil 0.8kg, wintergreen 0.8kg, menthol 1kg, poloxamer 407 1kg, xylitol 0.6kg, edible ethanol
220kg, mustard cooking liquor 0.51kg, rose and chrysanthemum extract liquid 0.51kg, pure water 807kg,.
The preparation method of draft antimicrobial fluid of the present invention, specific preparation process are：
(1) each component is weighed according to above-mentioned mass percent, part pure water is taken to be heated to 55-60 DEG C, be slowly added to moor
Luo Shamu 407 stirs 20-30min, until poloxamer is completely dissolved, obtains component A；
(2) thymol, caryophyllus oil, eucalyptus oil, wintergreen, menthol are sequentially added into edible ethanol, are stirred to complete
Fully dissolved, as component B；
(3) xylitol, rose and chrysanthemum extract liquid are added in the pure water of part, are stirred, until dissolution, as group
Divide C；
(4) mustard is put into micro-wave oven, at 140-160 DEG C, after baking 5-8 minutes, is ground into dry powder, mustard is done
The sodium bicarbonate aqueous solution that mass concentration is 0.5-0.7% is added in powder, and sealing storage 0.5-1 hours, is then placed in after mixing evenly
Boiling in distilling apparatus, taking distillate cooling is mustard cooking liquor；
(5) B component, component C are successively slowly added into component A, obtain A, B and component C mixed liquor, then by mustard
Cooking liquor is added in A, B and component C mixed liquor, adds purified water remainder, and 120 mesh filter after mixing evenly, then through filling and
Packaging, obtains draft antimicrobial fluid.
The preparation method of the rose and chrysanthemum extract liquid is：Rose and chrysanthemum are dried, according to 1:1 mass ratio
It is put into after mixing in Soxhlet reflux unit, and pure water is added in reflux unit, refluxing extraction 4-6 hours, returned what is obtained
Flow liquid is concentrated into the one third of volume, obtains rose and chrysanthemum extract liquid.
Claims (5)
1. a kind of draft antimicrobial fluid, which is characterized in that the component including following mass percent：Thymol 0.06-0.10%,
Caryophyllus oil 0.03-0.08%, eucalyptus oil 0.03-0.08%, wintergreen 0.03-0.08%, menthol 0.05-0.10% moor sieve
Husky 407 0.7-1.0% of nurse, xylitol 0.4-0.6%, edible ethanol 18.0-22.0%, flavorant 0-0.1% the rest is
Pure water, total amount 100%.
2. draft antimicrobial fluid according to claim 1, which is characterized in that the preparation method of draft antimicrobial fluid is specific to make
It is for technique：
(1) each component is weighed according to above-mentioned mass percent, takes part pure water to be heated to 55-60 DEG C, is slowly added to Bo Luosha
Nurse 407 stirs 20-30min, until poloxamer is completely dissolved, obtains component A；
(2) thymol, caryophyllus oil, eucalyptus oil, wintergreen, menthol are sequentially added into edible ethanol, are stirred to completely molten
Solution, as component B；
(3) xylitol, flavorant are added in the pure water of part, are stirred, until dissolution, as component C；
(4) B component, component C are successively slowly added into component A, obtain A, B and component C mixed liquor, be then added remaining pure
Water purification, 120 mesh filter after mixing evenly, then through filling and packaging, obtain draft antimicrobial fluid.
3. draft antimicrobial fluid according to claim 2, which is characterized in that draft antimicrobial fluid further includes mustard cooking liquor, institute
It is common fruity perfume or rose and chrysanthemum extract liquid with flavorant.
4. draft antimicrobial fluid according to claim 3, which is characterized in that the preparation method of the mustard cooking liquor is：It will
Mustard is put into micro-wave oven, at 140-160 DEG C, after baking 5-8 minutes, is ground into dry powder, and it is dense that quality is added in mustard dry powder
Degree is the sodium bicarbonate aqueous solution of 0.5-0.7%, and sealing storage 0.5-1 hours, is then placed in distilling apparatus and steams after mixing evenly
It boils, taking distillate cooling is mustard cooking liquor.Mustard cooking liquor is added in step (4) A, B and C group mixed liquor.
5. draft antimicrobial fluid according to claim 4, which is characterized in that the preparation side of the rose and chrysanthemum extract liquid
Method is：Rose and chrysanthemum are dried, according to 1:It is put into Soxhlet reflux unit after 1 mass ratio mixing, and in reflux unit
Obtained phegma refluxing extraction 4-6 hours, is concentrated into the one third of volume by middle addition pure water, obtain rose and
Chrysanthemum extract liquid.
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| CN201810739266.6A CN108815232A (en) | 2018-07-06 | 2018-07-06 | A kind of draft antimicrobial fluid |
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| CN201810739266.6A CN108815232A (en) | 2018-07-06 | 2018-07-06 | A kind of draft antimicrobial fluid |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109402218A (en) * | 2018-11-19 | 2019-03-01 | 湖南省健缘医疗科技有限公司 | The disinfection experiment method of compound herbal disinfectant |
| CN110680780A (en) * | 2019-08-21 | 2020-01-14 | 广州市尚昇生物科技有限公司 | Thyme mouthwash oil and preparation method thereof |
| CN110938497A (en) * | 2019-12-06 | 2020-03-31 | 黎明职业大学 | Tooth cup cleaning agent |
| CN111991613A (en) * | 2020-09-28 | 2020-11-27 | 青岛鸿蒙草本医疗科技有限公司 | Liquid dressing and preparation method thereof |
| CN115998796A (en) * | 2022-12-31 | 2023-04-25 | 清草诗健康科技(天津)有限公司 | Antibacterial and anti-inflammatory oral rinse solution and preparation method and application thereof |
-
2018
- 2018-07-06 CN CN201810739266.6A patent/CN108815232A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109402218A (en) * | 2018-11-19 | 2019-03-01 | 湖南省健缘医疗科技有限公司 | The disinfection experiment method of compound herbal disinfectant |
| CN110680780A (en) * | 2019-08-21 | 2020-01-14 | 广州市尚昇生物科技有限公司 | Thyme mouthwash oil and preparation method thereof |
| CN110938497A (en) * | 2019-12-06 | 2020-03-31 | 黎明职业大学 | Tooth cup cleaning agent |
| CN111991613A (en) * | 2020-09-28 | 2020-11-27 | 青岛鸿蒙草本医疗科技有限公司 | Liquid dressing and preparation method thereof |
| CN115998796A (en) * | 2022-12-31 | 2023-04-25 | 清草诗健康科技(天津)有限公司 | Antibacterial and anti-inflammatory oral rinse solution and preparation method and application thereof |
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Application publication date: 20181116 |