CN108309315A - A kind of wearable blood glucose monitoring device and its system - Google Patents

A kind of wearable blood glucose monitoring device and its system Download PDF

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Publication number
CN108309315A
CN108309315A CN201810151383.0A CN201810151383A CN108309315A CN 108309315 A CN108309315 A CN 108309315A CN 201810151383 A CN201810151383 A CN 201810151383A CN 108309315 A CN108309315 A CN 108309315A
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China
Prior art keywords
body temperature
glucose
measured value
value
control unit
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CN201810151383.0A
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Chinese (zh)
Inventor
刘厚为
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Foshan Rock Witt Technology Co Ltd
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Foshan Rock Witt Technology Co Ltd
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Priority to CN201810151383.0A priority Critical patent/CN108309315A/en
Publication of CN108309315A publication Critical patent/CN108309315A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0004—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by the type of physiological signal transmitted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/14517—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for sweat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6802—Sensor mounted on worn items
    • A61B5/681—Wristwatch-type devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/683—Means for maintaining contact with the body
    • A61B5/6832—Means for maintaining contact with the body using adhesives
    • A61B5/6833—Adhesive patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient ; user input means
    • A61B5/7405—Details of notification to user or communication with user or patient ; user input means using sound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient ; user input means
    • A61B5/7455—Details of notification to user or communication with user or patient ; user input means characterised by tactile indication, e.g. vibration or electrical stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient ; user input means
    • A61B5/746—Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient ; user input means
    • A61B5/7465—Arrangements for interactive communication between patient and care services, e.g. by using a telephone network
    • A61B5/747—Arrangements for interactive communication between patient and care services, e.g. by using a telephone network in case of emergency, i.e. alerting emergency services
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01K—MEASURING TEMPERATURE; MEASURING QUANTITY OF HEAT; THERMALLY-SENSITIVE ELEMENTS NOT OTHERWISE PROVIDED FOR
    • G01K13/00—Thermometers specially adapted for specific purposes
    • G01K13/20—Clinical contact thermometers for use with humans or animals

Abstract

The present invention provides a kind of blood glucose monitoring systems,It includes mobile terminal,And include wearable ontology and the paste section on wearable ontology,The wearable ontology includes wearable component,Flexible display screen,Control unit,Body temperature transducer and communication section,The paste section includes glucose sensor,Communicator and controller,The paste section Pasting is in human skin,Monitor value is simultaneously sent to the control unit by the body temperature of the body temperature transducer monitoring human body,The measured value of glucose in the glucose sensor monitoring human sweat is simultaneously sent to the controller,The measured value is sent to the communication section by the controller by the communicator,The measured value is sent to the control unit by the communication section,The control unit also controls the flexible display screen and shows the monitor value of the body temperature and the measured value of the glucose,And the measured value is sent to by the mobile terminal by the communication section.

Description

A kind of wearable blood glucose monitoring device and its system
Technical field
The invention belongs to blood sugar for human body monitoring or detection field, more particularly to a kind of wearable blood glucose monitoring device and Its system.The present invention is that parent application number is 201710176145.0, a kind of entitled wearable blood glucose monitoring device And its system, the applying date are the divisional application of the application for a patent for invention on March 23rd, 2017.
Background technology
Constantly universal and technology with wearable device is widely popularized, and is brought to medical and health industry far-reaching It influences, and has pushed directly on the fast development of intelligent medical product.Current various wearable products are for medical treatment ＆ health Monitoring application, is fully utilized its advantage to realize long-range on-line monitoring or self-monitoring, such as the heart rate of human body, blood pressure Monitoring.
And present society is due to industrialized quick process, great variety has occurred in food composition, and diabetes etc. are " rich and honour The ratio of disease " is increasing or even it has also appeared the trend of rejuvenation, and inventor even has found have high school student that diabetes occur Situation, and its monitoring is particularly important for diabetes patient.
In currently available technology, to its monitoring often through the glucose level measured in blood, have with reply The fluctuation of the blood glucose of patient is to place the complication of the kidney because elevated blood glucose levels cause, nervous system, blood vessel etc., in turn It is guarded and is treated.These technologies are can effectively to be monitored to blood glucose and provide many reference frames, such as Chinese patent CN205234512 provides for a kind of wearable high-precision blood sugar detection equipment.But technology used at present It is all based on the monitoring of blood glucose, that is to say, that wound and blood sampling, this prior art is needed to be not suitable for the day of non-professional patient It is often used, and wound is needed on the one hand to have pain and use feeling is bad, and have the possibility for causing infection.Meanwhile blood glucose Monitoring needs manually operated, that is to say, that if user it is busier or forget operate and cause monitoring something lost Leakage, or even even if using other alerting patterns but if having ignored risk.To which it cannot reliably be user To effective daily monitoring, to lose the use advantage of wearable device.
Based on this, inventors herein propose a kind of wearable blood glucose monitoring device used especially suitable for daily monitoring and Its system.
Invention content
One aspect of the present invention provides a kind of wearable blood glucose monitoring device, including wearable ontology and wearable Paste section on ontology, the wearable ontology include wearable component, flexible display screen, control unit, body temperature transducer and lead to News portion, the paste section include glucose sensor, communicator and controller, which is characterized in that the paste section Pasting in Human skin, and the wearable ontology by the wearable component is worn on human skin to correspond to the paste section viscous Monitor value is simultaneously sent to the control unit by the position of patch, the body temperature of the body temperature transducer monitoring human body, and the glucose passes The measured value of glucose in sensor monitoring human sweat is simultaneously sent to the controller, and the controller passes through the communicator The measured value is sent to the communication section, the measured value is sent to the control unit, the control by the communication section Portion also controls the flexible display screen and shows the monitor value of the body temperature and the measured value of the glucose, and by described logical The measured value is sent to mobile terminal by news portion.
Preferably, the glucose sensor is graphene flexible patch sensor.
Preferably, body temperature threshold value, and the monitor value of its body temperature and the body are also prestored in the control unit Warm threshold value, and when the monitor value of the body temperature is more than the body temperature threshold value, the control unit sends one by the communication section Request signal, the controller enable the glucose by some cycles after receiving the request signal by communicator and pass Sensor obtains the measured value of the glucose.
On the other hand, the present invention gives a kind of blood glucose monitoring system comprising mobile terminal, and include wearable Body and the paste section on wearable ontology, the wearable ontology include wearable component, flexible display screen, control unit, Body temperature transducer and communication section, the paste section include glucose sensor, communicator and controller, which is characterized in that described Paste section Pasting is in human skin, and the wearable ontology is worn on human skin pair by the wearable component Monitor value is simultaneously sent to the control by the position for answering the paste section to paste, the body temperature of the body temperature transducer monitoring human body Portion, the glucose sensor monitor the measured value of the glucose in human sweat and are sent to the controller, the control The measured value is sent to the communication section by device by the communicator, and the measured value is sent to described by the communication section Control unit, the control unit also control the measurement that the flexible display screen shows the monitor value and the glucose of the body temperature Value, and the measured value is sent to by the mobile terminal by the communication section.
Preferably, body temperature threshold value, and the monitor value of its body temperature and the body are also prestored in the control unit Warm threshold value, and when the monitor value of the body temperature is more than the body temperature threshold value, the control unit sends one by the communication section Request signal, the controller enable the glucose by some cycles after receiving the request signal by communicator and pass Sensor obtains the measured value of the glucose.
Preferably, the mobile terminal has communication device, display unit and central processing unit, the central processing unit difference Connect the communication device and display unit, and its measured value obtained by the communication device and after being pre-processed with One threshold value of warning to prestore is compared, and passes through the display when the pretreated measured value is more than the threshold value of warning Portion's display alarm.
Specific embodiment
This explanation is described further with reference to embodiments, it should be appreciated that below not as to the present invention Limitation, i.e. deformation of the present invention under its core concept is still within protection domain.
Embodiment one.
The present embodiment is related to a kind of wearable blood glucose monitoring device, including wearable ontology and on wearable ontology Paste section, the wearable ontology includes wearable component, flexible display screen, control unit, body temperature transducer and communication section, institute It includes glucose sensor, communicator and controller to state paste section, which is characterized in that the paste section Pasting is in human body skin Skin, and the wearable ontology is worn on human skin by the wearable component and corresponds to the position that the paste section is pasted It sets, monitor value is simultaneously sent to the control unit, the glucose sensor prison by the body temperature of the body temperature transducer monitoring human body The measured value for the glucose surveyed in human sweat is simultaneously sent to the controller, and the controller will be described by the communicator Measured value is sent to the communication section, and the measured value is sent to the control unit by the communication section, and the control unit is also controlled It makes the flexible display screen and shows the monitor value of the body temperature and the measured value of the glucose, and will by the communication section The measured value is sent to mobile terminal.
Here wearable ontology can select the configuration of various wearable devices common in the market, such as bracelet, armlet Deng, preferred wrist-watch in this implementation, and the paste section is further constrained by the wrist strap of wrist-watch so that paste section one side energy Enough it is close to skin, on the other hand prevents from touching paste section when using and leading to falling off for paste section.On the other hand, paste section is selected It is the splendid product of permeability, user will not generate sense of discomfort because of stickup.
Preferably, the glucose sensor is graphene flexible patch sensor.That the sensor is selected is Jin great Jiong The patch-type of a novel sensor that team's research and development are promoted, the gold net processing formed using addition gold particle in graphene is passed Sensor, size can accomplish also smaller than identity card, and it can detect glucose water therein by the sweat of body surface It is flat, and then obtain the dynamic glucose value of human body.
Preferably, body temperature threshold value, and the monitor value of its body temperature and the body are also prestored in the control unit Warm threshold value, and when the monitor value of the body temperature is more than the body temperature threshold value, the control unit sends one by the communication section Request signal, the controller enable the glucose by some cycles after receiving the request signal by communicator and pass Sensor obtains the measured value of the glucose.After being arranged as progress, this product can need not be opened all at any time The monitoring of blood glucose is carried out by opening sensor, and infer whether human body has the possibility of perspiration by the monitor value of body temperature.And its This equipment is in standby and reduces consumption in the case of him.
Embodiment two.
The present invention gives a kind of blood glucose monitoring systems comprising mobile terminal, and include wearable ontology and can The paste section on ontology is dressed, the wearable ontology includes wearable component, flexible display screen, control unit, body temperature transducer And communication section, the paste section include glucose sensor, communicator and controller, which is characterized in that the paste section can glue It is affixed on human skin, and the wearable ontology is worn on human skin by the wearable component and corresponds to the stickup Monitor value is simultaneously sent to the control unit, the grape by the position that portion is pasted, the body temperature of the body temperature transducer monitoring human body The measured value of glucose in sugared Sensor monitoring human sweat is simultaneously sent to the controller, and the controller passes through described logical The measured value is sent to the communication section by news device, and the measured value is sent to the control unit by the communication section, described Control unit also controls the flexible display screen and shows the monitor value of the body temperature and the measured value of the glucose, and passes through institute It states communication section and the measured value is sent to the mobile terminal.
Preferably, body temperature threshold value, and the monitor value of its body temperature and the body are also prestored in the control unit Warm threshold value, and when the monitor value of the body temperature is more than the body temperature threshold value, the control unit sends one by the communication section Request signal, the controller enable the glucose by some cycles after receiving the request signal by communicator and pass Sensor obtains the measured value of the glucose.
Preferably, the mobile terminal has communication device, display unit and central processing unit, the central processing unit difference Connect the communication device and display unit, and its measured value obtained by the communication device and after being pre-processed with One threshold value of warning to prestore is compared, and passes through the display when the pretreated measured value is more than the threshold value of warning Portion's display alarm.
Embodiment three.
The present embodiment gives a kind of blood glucose monitoring system comprising mobile terminal, and include wearable ontology and Paste section on wearable ontology, the wearable ontology include wearable component, flexible display screen, control unit, body temperature biography Sensor and communication section, the paste section include glucose sensor, communicator and controller, which is characterized in that the paste section Pasting is in human skin, and the wearable ontology is worn on by the wearable component described in human skin correspondence The position that paste section is pasted, monitor value is simultaneously sent to the control unit by the body temperature of the body temperature transducer monitoring human body, described The measured value of glucose in glucose sensor monitoring human sweat is simultaneously sent to the controller, and the controller passes through institute It states communicator and the measured value is sent to the communication section, the measured value is sent to the control unit by the communication section, The control unit also controls the flexible display screen and shows the monitor value of the body temperature and the measured value of the glucose, and leads to It crosses the communication section and the measured value is sent to the mobile terminal.It is preinstalled with matched APP in the mobile terminal and comes side Just user operates this system, such as reading histories data, type of alarm is arranged, long-range alternative contact people is arranged, and is needing Automatic actively contact etc. is carried out when wanting.
In addition glucose sensor is graphene flexible patch sensor.What the sensor was selected is the research and development of Jin great Jiong team A novel sensor promoted, the patch-type sensor for using the gold net that addition gold particle is formed in graphene to process, Size can accomplish also smaller than identity card, and it can detect glucose level therein by the sweat of body surface, in turn Obtain the dynamic glucose value of human body.
Preferably, body temperature threshold value, and the monitor value of its body temperature and the body are also prestored in the control unit Warm threshold value, and when the monitor value of the body temperature is more than the body temperature threshold value, the control unit sends one by the communication section Request signal, the controller enable the glucose by some cycles after receiving the request signal by communicator and pass Sensor obtains the measured value of the glucose.
The setting of the body temperature threshold value, the present embodiment have done an improvement, i.e., no longer use fixed threshold commonly used in the art The mode of value, this system when first used, control unit obtains the average body of user by the temperature monitoring of a cycle Then temperature will increase by 0.5 DEG C of conduct threshold value again on the basis of the mean body temperature.It is such to improve so that this system is more bonded The actual conditions of human body.
Preferably, the mobile terminal has communication device, display unit and central processing unit, the central processing unit difference Connect the communication device and display unit, and its measured value obtained by the communication device and after being pre-processed with One threshold value of warning to prestore is compared, and passes through the display when the pretreated measured value is more than the threshold value of warning Portion's display alarm.
And in Practical experiments, inventor also found a problem, and the early warning for being exactly blood glucose is to need in advance, on the one hand The monitoring of the glucose of body fluid be one lag monitoring, from the level of the glucose of body fluid come react blood glucose there are one The backwardness of time, and the variation of blood glucose is a regular process, i.e., it should be according to the changing rule and lag of blood glucose Period studies the true change of blood sugar rule of simulation and accomplishes timely early warning.
For this, inventor has carried out very effective practice, firstly for the dextrose equivalent of sweat, according to fixed Period is sampled, such as samples W times and obtain the ordered series of numbers of a W data, is then identified to the ordered series of numbers and is established one Then a corresponding mathematical model is predicted that (sampling number W is bigger, and prediction is more smart according to the model to the data after W times Really).
The mathematical model is described as follows：
The first step obtains the rule noise of mathematical model：
Xw-a1X1-a2X2-a3X3-a4X4…-aW-1Xw-1=ξ, wherein XiIt indicates to sample every time in W sampling and obtain The value of glucose, aiIt indicates fitting coefficient, meets ∑ ai=1 preset condition, wherein i are 1 natural numbers for arriving W, thus To the rule noise figure ξ obtained after W sampling；
Second step calculates the predicted value of the y times sampling after W sampling：
Xw+y=y* ξ+Xw；It will be apparent that when y is smaller, prediction is about accurate, practice have shown that after prediction is more than 50 times Sampling predicted value no longer has using meaning.
And the fitting coefficient a in model aboveiSetting, the present embodiment uses BP neural network algorithm and obtained It takes, it can also easily be obtained by other neural network algorithms certainly, and inventor has also passed through heredity Algorithm carries out the fitting of the parameter, and actual effect is all similar, only itself and programming skill difference meeting of algorithm The speed that affecting parameters obtain.Certainly above obtain on software and hardware has not all been problem, and applicant is no longer herein It repeats.
Example IV.
The present embodiment gives a kind of blood glucose monitoring system comprising mobile terminal, and include wearable ontology and Paste section on wearable ontology, the wearable ontology include wearable component, flexible display screen, control unit, body temperature biography Sensor and communication section, the paste section include glucose sensor, communicator and controller, which is characterized in that the paste section Pasting is in human skin, and the wearable ontology is worn on by the wearable component described in human skin correspondence The position that paste section is pasted, monitor value is simultaneously sent to the control unit by the body temperature of the body temperature transducer monitoring human body, described The measured value of glucose in glucose sensor monitoring human sweat is simultaneously sent to the controller, and the controller passes through institute It states communicator and the measured value is sent to the communication section, the measured value is sent to the control unit by the communication section, The control unit also controls the flexible display screen and shows the monitor value of the body temperature and the measured value of the glucose, and leads to It crosses the communication section and the measured value is sent to the mobile terminal.It is preinstalled with matched APP in the mobile terminal and comes side Just user operates this system, such as reading histories data, type of alarm is arranged, long-range alternative contact people is arranged, and is needing Automatic actively contact etc. is carried out when wanting.
In addition glucose sensor is graphene flexible patch sensor.What the sensor was selected is the research and development of Jin great Jiong team A novel sensor promoted, the patch-type sensor for using the gold net that addition gold particle is formed in graphene to process, Size can accomplish also smaller than identity card, and it can detect glucose level therein by the sweat of body surface, in turn Obtain the dynamic glucose value of human body.
Preferably, body temperature threshold value, and the monitor value of its body temperature and the body are also prestored in the control unit Warm threshold value, and when the monitor value of the body temperature is more than the body temperature threshold value, the control unit sends one by the communication section Request signal, the controller enable the glucose by some cycles after receiving the request signal by communicator and pass Sensor obtains the measured value of the glucose.
The setting of the body temperature threshold value, the present embodiment have done an improvement, i.e., no longer use fixed threshold commonly used in the art The mode of value, this system when first used, control unit obtains the average body of user by the temperature monitoring of a cycle Then temperature will increase by 0.5 DEG C of conduct threshold value again on the basis of the mean body temperature.It is such to improve so that this system is more bonded The actual conditions of human body.
Preferably, the mobile terminal has communication device, display unit and central processing unit, the central processing unit difference Connect the communication device and display unit, and its measured value obtained by the communication device and after being pre-processed with One threshold value of warning to prestore is compared, and passes through the display when the pretreated measured value is more than the threshold value of warning Portion's display alarm.
It carries out the pretreated reason to be in Practical experiments, inventor also found a problem, be exactly the pre- of blood glucose Police is to need in advance, and the monitoring of the glucose of one side body fluid has been a lag monitoring, from the water of the glucose of body fluid It puts down to react blood glucose there are one the backwardness of time, and the variation of blood glucose is a regular governed process, i.e., should Accomplish timely early warning according to the period of the changing rule of blood glucose and lag to study the true change of blood sugar rule of simulation.
For this, inventor has carried out very effective practice, firstly for the dextrose equivalent of sweat, according to fixed Period is sampled, such as samples W times and obtain the ordered series of numbers of a W data, is then identified to the ordered series of numbers and is established one Then a corresponding mathematical model is predicted that (sampling number W is bigger, and prediction is more smart according to the model to the data after W times Really).This method is the ingenious prediction algorithm discrete in conjunction with as multiple types of applicant and is combined design, is also equipped with prediction It is accurate to occupy the especially few advantage of resource, it can be carried out on intelligent mobile terminal.
The mathematical model is described as follows：
The first step obtains the rule noise of mathematical model：
Xw-a1X1-a2X2-a3X3-a4X4…-aW-1Xw-1=ξ, wherein XiIt indicates to sample every time in W sampling and obtain The value of glucose, aiIt indicates fitting coefficient, meets ∑ ai=1 preset condition, wherein i are 1 natural numbers for arriving W, thus To the noise figure ξ obtained after W sampling；
Second step calculates the predicted value of the 1st sampling after W sampling：
Xw+1=ξ+Xw；Similar, the predicted value of n-th after can obtaining, at the same time, system continue to obtain true Dextrose equivalent carries out rolling forecast to substitute into last formula.
And the fitting coefficient a in model aboveiSetting, the present embodiment uses BP neural network algorithm and obtained It takes, it can also easily be obtained by other neural network algorithms certainly, and inventor has also passed through heredity Algorithm carries out the fitting of the parameter, and actual effect is all similar, only itself and programming skill difference meeting of algorithm The speed that affecting parameters obtain.Certainly above obtain on software and hardware has not all been problem, and applicant is no longer herein It repeats.
In this way, the present embodiment energy advanced by one cycle obtains predicted value, experiments have shown that can accurate acquisition 60min Predicted value.
Then by the predicted value plus an individual Watch Error value c, the error amount is for embodying sweat dextrose equivalent and blood The error of sugar value, we are to have obtained the predicted value of a blood glucose in this way, are then provided with the several of blood glucose in the terminal A threshold value, after the predicted value of blood glucose is triggered to the threshold value of different ranks, mobile terminal takes different actions to correspond to, such as Level-one sends out vibrations and audible alarm, and two level sends phone and short message to hospital and emergency contact.
Embodiment five.
The present embodiment gives a kind of blood glucose monitoring system comprising mobile terminal, and include wearable ontology and Paste section on wearable ontology, the wearable ontology include wearable component, flexible display screen, control unit, body temperature biography Sensor and communication section, the paste section include glucose sensor, communicator and controller, which is characterized in that the paste section Pasting is in human skin, and the wearable ontology is worn on by the wearable component described in human skin correspondence The position that paste section is pasted, monitor value is simultaneously sent to the control unit by the body temperature of the body temperature transducer monitoring human body, described The measured value of glucose in glucose sensor monitoring human sweat is simultaneously sent to the controller, and the controller passes through institute It states communicator and the measured value is sent to the communication section, the measured value is sent to the control unit by the communication section, The control unit also controls the flexible display screen and shows the monitor value of the body temperature and the measured value of the glucose, and leads to It crosses the communication section and the measured value is sent to the mobile terminal.It is preinstalled with matched APP in the mobile terminal and comes side Just user operates this system, such as reading histories data, type of alarm is arranged, long-range alternative contact people is arranged, and is needing Automatic actively contact etc. is carried out when wanting.
In addition glucose sensor is graphene flexible patch sensor.What the sensor was selected is the research and development of Jin great Jiong team A novel sensor promoted, the patch-type sensor for using the gold net that addition gold particle is formed in graphene to process, Size can accomplish also smaller than identity card, and it can detect glucose level therein by the sweat of body surface, in turn Obtain the dynamic glucose value of human body.
Preferably, body temperature threshold value, and the monitor value of its body temperature and the body are also prestored in the control unit Warm threshold value, and when the monitor value of the body temperature is more than the body temperature threshold value, the control unit sends one by the communication section Request signal, the controller enable the glucose by some cycles after receiving the request signal by communicator and pass Sensor obtains the measured value of the glucose.
The setting of the body temperature threshold value, the present embodiment have done an improvement, i.e., no longer use fixed threshold commonly used in the art The mode of value, this system when first used, control unit obtains the average body of user by the temperature monitoring of a cycle Then temperature will increase by 0.5 DEG C of conduct threshold value again on the basis of the mean body temperature.It is such to improve so that this system is more bonded The actual conditions of human body.
Preferably, the mobile terminal has communication device, display unit and central processing unit, the central processing unit difference Connect the communication device and display unit, and its measured value obtained by the communication device and after being pre-processed with One threshold value of warning to prestore is compared, and for this firstly for the dextrose equivalent of sweat, is adopted according to the fixed period Sample, such as the ordered series of numbers of a W data is sampled W times and obtains, then the ordered series of numbers is identified and establishes a corresponding number Then word model is predicted (sampling number W is bigger, and prediction is more accurate) data after W times according to the model.
The mathematical model is described as follows：
The first step obtains the deviation of mathematical model：
Xw-a1X1-a2X2-a3X3-a4X4…-aW-1Xw-1=δ, wherein XiIt indicates to sample every time in W sampling and obtain The value of glucose, aiIt indicates fitting coefficient, meets ∑ ai=1 preset condition, wherein i are 1 natural numbers for arriving W, thus To the deviation δ obtained after W sampling；
Second step calculates the predicted value of the 1st sampling after W sampling：
Xw+1=δ+Xw；Similar, 1 predicted value after can obtaining, at the same time, system continue to obtain true Portugal Grape sugar value carries out rolling forecast to substitute into last formula, i.e., substitutes into W=W+1 in previous step to obtain newer deviation Value δ.The method is the experiment proved that prediction is very accurate.It is more suitable for sampling period larger situation, will not cause so pre- The time of survey is too short and the case where cannot effectively judging.
And the fitting coefficient a in model aboveiSetting, the present embodiment use BP neural network algorithm carry out optimizing It obtains, it can also easily be obtained by other neural network algorithms certainly, and inventor has also passed through something lost Propagation algorithm carries out the fitting of the parameter, and actual effect is all similar, and only itself and programming skill of algorithm are different The speed that meeting affecting parameters obtain.Certainly above obtain on software and hardware has not all been problem, and applicant is not herein It repeats again.
In this way, the present embodiment energy advanced by one cycle obtains predicted value, experiments have shown that can more accurately obtain Predicted value within 15min.
Then by the predicted value plus an individual Watch Error value c, the error amount is for embodying sweat dextrose equivalent and blood The error of sugar value, we are to have obtained the predicted value of a blood glucose in this way, are then provided with the several of blood glucose in the terminal A threshold value.In the present embodiment, wearable device also sets up melbine injection release device, can be controlled and into Row injection operation.After the predicted value of blood glucose is triggered to the threshold value of different ranks, mobile terminal takes next pair of different action Answer, level-one send out vibrations and audible alarm and send out signal control the melbine injection release device user is noted It penetrates, and mobile terminal is reminded to hospital and emergency contact's transmission short message automatically after touching secondary alarm.
The above embodiment is interpreted as being merely to illustrate the present invention rather than limit the scope of the invention.It is reading After the content of the record of the present invention, technical staff can make various changes or modifications the present invention, these equivalence changes and Modification equally falls into the scope of the claims in the present invention.

Claims (2)

1. a kind of blood glucose monitoring system comprising mobile terminal, and include wearable ontology and gluing on wearable ontology Patch portion, the wearable ontology include wearable component, flexible display screen, control unit, body temperature transducer and communication section, described viscous Patch portion includes glucose sensor, communicator and controller, and the paste section Pasting is and described wearable in human skin Ontology is worn on human skin by the wearable component and corresponds to the position that the paste section is pasted, the body temperature transducer It monitors the body temperature of human body and monitor value is sent to the control unit, the grape in the glucose sensor monitoring human sweat The measured value of sugar is simultaneously sent to the controller, and the measured value is sent to described logical by the controller by the communicator The measured value is sent to the control unit by news portion, the communication section, and the control unit also controls the Flexible Displays screen display Show the monitor value of the body temperature and the measured value of the glucose, and the measured value is sent to by institute by the communication section State mobile terminal；
The glucose sensor is graphene flexible patch sensor；
Body temperature threshold value, and the monitor value of its body temperature and the body temperature threshold value are also prestored in the control unit, and When the monitor value of the body temperature is more than the body temperature threshold value, the control unit sends a request signal, institute by the communication section It states controller and glucose sensor acquisition institute is enabled by some cycles after receiving the request signal by communicator State the measured value of glucose；
The mobile terminal has communication device, display unit and central processing unit, and the central processing unit is separately connected described logical Interrogate device and display unit, and it obtains the measured value by the communication device and prestores with one after being pre-processed pre- Alert threshold value is compared, and is shown and is accused by the display unit when the pretreated measured value is more than the threshold value of warning It is alert.
2. the system as claimed in claim 1, which is characterized in that the pretreatment includes：
Sampling is carried out W times and the ordered series of numbers of one W measured value of acquisition according to some cycles to the glucose of sweat, then The ordered series of numbers is identified and establishes a corresponding mathematical model, then the data after W times are carried out according to the mathematical model Prediction, the mathematical model includes following operating procedure：
The first step obtains the rule noise figure of mathematical model according to the following formula：
XW-a1X1-a2X2-a3X3-a4X4…-aW-1XW-1=ξ, wherein XiTo sample obtained glucose every time in W sampling Measured value, aiFor fitting coefficient, and ∑ ai=1, wherein i are 1 natural numbers for arriving W, after thus having obtained W sampling of carry out Obtain a rule noise figure ξ；
Second step calculates the predicted value of the y times sampling after W sampling：
XW+y=y* ξ+XW；
The wherein described fitting coefficient aiIt is calculated and is obtained by BP neural network algorithm.
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