CN108309286A - Sleep disturbance detects treatment system - Google Patents

Sleep disturbance detects treatment system Download PDF

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Publication number
CN108309286A
CN108309286A CN201711352088.3A CN201711352088A CN108309286A CN 108309286 A CN108309286 A CN 108309286A CN 201711352088 A CN201711352088 A CN 201711352088A CN 108309286 A CN108309286 A CN 108309286A
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ahi
sleep
hour
phases
signal
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尹又
刘艳
田青
庄建华
马天君
李澎
许义新
徐谨
毛蕾
宋明睿
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Second Affiliated Hospital Army Medical University
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Second Affiliated Hospital Army Medical University
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316Modalities, i.e. specific diagnostic methods
    • A61B5/369Electroencephalography [EEG]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/08Detecting, measuring or recording devices for evaluating the respiratory organs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/103Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/11Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb
    • A61B5/1116Determining posture transitions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/103Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/11Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb
    • A61B5/113Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb occurring during breathing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14542Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring blood gases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316Modalities, i.e. specific diagnostic methods
    • A61B5/318Heart-related electrical modalities, e.g. electrocardiography [ECG]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316Modalities, i.e. specific diagnostic methods
    • A61B5/389Electromyography [EMG]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316Modalities, i.e. specific diagnostic methods
    • A61B5/398Electrooculography [EOG], e.g. detecting nystagmus; Electroretinography [ERG]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/48Other medical applications
    • A61B5/4806Sleep evaluation
    • A61B5/4812Detecting sleep stages or cycles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/74Details of notification to user or communication with user or patient ; user input means
    • A61B5/746Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms

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  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

The present invention discloses a kind of sleep disturbance detection treatment system, and biological information logging modle acquires the biological information of patient;Patient's states are divided into waking state, NREM phases (being divided into I, II, III, IV phase) and REM phases by analysis module based on biological information, using under patient awoke's state of acquisition eegαwave, respiratory air flow pressure amplitude, blood oxygen saturation base value is as scaled values;60/ diagnostic phases total times of AHI=low pass gas numbers *, low pass gas are that 30% or more of respiratory air flow pressure signal decline scaled values occurs in NREM phases and REM phases and simultaneously declines with blood oxygen saturation to be more than or equal to scaled values 4%, and the duration was more than or equal to 10 seconds;Judge whether AHI is more than setting number, triggering enters titration phase when being, titration phase mask is become closed and is stepped up to oxygen concentration or flow from open, and the biological information of record reaches certain standard and enters treatment stage, and treatment stage ends in awake from patient's morning.

Description

Sleep disturbance detects treatment system
Technical field
The present invention relates to the field of medical instrument technology, and treatment system is detected more particularly to a kind of sleep disturbance.
Background technology
Sleep almost occupies time of people's all one's life one third, in modern society, with the quickening pace of modern life with life Pressure living it is increasingly huge, sleeping problems are increasingly notable in crowd, and seriously affect people’s lives, work and physical and mental health, Medical institutions accept sleep disturbance patient numbers for medical treatment and increasingly increase.
Medical institutions mostly find and diagnose sleep disturbance by sleep analysis monitor technology (PSG) now, main former Reason is admitted to hospital to accept doubtful sleep disturbance patient for medical treatment, electric by the brain when human body disposes a variety of electrodes that one night of patient sleeps, Eye electricity, myoelectricity, electrocardio, the data variations such as oxygen saturation by electrode plate, signal amplifier, filter be aggregated into computer into Row record, manual analysis, to obtain corresponding diagnosis.But patient if you need to treat and therapeutic effect assess, it is still necessary to again It is admitted to hospital or even is repeatedly admitted to hospital, repeated detection above-mentioned parameter index carries out manual analysis in treatment corresponding with diagnosis, to obtain Obtain therapeutic scheme finally.This not only considerably increases the workload of medical institutions, also make sleep disturbance patient because repeatedly preengaging, It goes to a doctor and extends the diagnosis and treatment period, be unfavorable for Rehabilitation.
Invention content
The present invention is in view of the problems of the existing technology and insufficient, provides a kind of sleep disturbance detection treatment system, can be with Make that patient integrates medical diagnosis on disease in primary medical, critical value early warning and processing, therapeutic scheme are determined as one, solution patient The problems such as repeatedly medical, healthcare givers's duplication of labour.
The present invention is to solve above-mentioned technical problem by following technical proposals:
The present invention provides a kind of sleep disturbance detection treatment system, and feature is comprising a biological information records mould Block and an analysis module;
The biological information logging modle is used to acquire the various biological informations of doubtful sleep disturbance patient, and those are biological Information is transmitted to the analysis module, those biological informations include eeg signal, electro-ocular signal, masseter electromyography signal, lower mentalis Electromyography signal, mentalis electromyography signal, sound of snoring vibration frequency signal, thorax abdomen fluctuating signal, body position signal, respiratory air flow pressure Force signal, blood oxygen saturation and electrocardiosignal;
The analysis module for the biological information based on acquisition by each Phase patient's state be divided into waking state, the NREM phases and REM phases, and the NREM phases are divided into I, II, III, IV phase, and by eegαwave, the respiratory air flow under patient awoke's state of acquisition Pressure amplitude, blood oxygen saturation base value are as scaled values;
60/ diagnostic phases total times of AHI=low pass gas numbers * are calculated, low pass gas is defined as occurring in NREM phases and REM phases Respiratory air flow pressure signal, which declines 30% or more of scaled values and declines simultaneously with blood oxygen saturation, is more than or equal to scaled values 4%, the duration is more than or equal to 10 seconds;
Judge whether AHI is more than a setting number, triggering is into titration phase when to be, titration phase mask is by opening Become closed and step up to oxygen concentration or flow, the biological information of record reaches certain standard and enters treatment stage, treatment Stage ends in awake from patient's morning.
Preferably, the analysis module analyzes diagnostic phases record information, AHI<5 times/hour are defined as no sleep Apnea;5 times/hour≤AHI<20 times/hour are defined as hypophypnosis apnea;20 times/hour≤AHI<40 times/ Hour, it is defined as moderate sleep apnea;AHI >=40 time/hour, it is defined as severe sleep apnea.
Preferably, AHI >=5 time/hour, and and chest and abdomen synchronous with sound of snoring movement exists when the generation of low pass gas event, definition For obstructive sleep apnea;AHI >=5 time/hour, and and chest and abdomen synchronous with sound of snoring movement disappears when the generation of low pass gas event It loses, is defined as centric sleep apnea;AHI >=5 time/hour, low pass gas event is synchronous with the sound of snoring when occurring and chest and abdomen are transported Dynamic to disappear, chest and abdomen movement restores prior to ventilation, is defined as mixed sleep apnea;Blood oxygen declines, exhales when the sound of snoring is recorded When the decline of suction amplitude does not constitute low pass gas standard, it is defined as benign snoring.
Preferably, body position is lateral position, dorsal position or prone position when body position signal records patient sleeps, divide Not calculating different positions generation low pass gas numbers can obtain:AHI >=5 time/hour, horizontal position AHI >=2 times lateral position AHI, lie on one's side Position sleeping time >=1 hour, lateral position AHI<15 times/hour are defined as orthostatic sleep apnea;Above-mentioned standard is not achieved It is then non-orthostatic.
Preferably, sleep disturbance detection treatment system further includes an alarm module;The alarm module is used for according to each life Object information, screening needs the sleep event of emergent management, by different colours indicator light and jingle bell alarm prompt attendant physician into Row processing;
The sleeping time that need to be alarmed is defined as follows:Cardiac monitoring finds malignant arrhythmia, and send out a warning simultaneously alarm equipment alarm; Blood oxygen saturation<80%, it sends out a warning;80≤blood oxygen saturation<90%, bright orange lamp;Brain electricity finds epilepsy wave, brilliant blue lamp;Breathing Amplitude or air-flow monitoring are less than brilliant white lamp;Do not occur the above situation, gives a green light;Above-mentioned five kinds of color indicator lights are permitted in addition to green light Perhaps it lights simultaneously.
Preferably, the eeg signal is acquired by eeg recording electrode, which is adopted by eye electrographic recording electrode Collection, the masseter electromyography signal are acquired by masseter recording electrode, which is acquired by lower mentalis recording electrode, The mentalis electromyography signal is acquired by chin recording electrode, which is acquired by sound of snoring recording electrode, the chest Abdomen fluctuating signal is acquired by chest and abdomen belt sensor, which is acquired by body position sensor, the breathing Stream pressure signal is believed by breathing current meter acquisition, the blood oxygen saturation by referring to the acquisition of arteries and veins oxygen detection and the electrocardio It number is acquired by electrocardioscanner, which is placed in the cardioelectric monitor electrode of the electrocardioscanner.
Preferably, the recording frequency of each recording device is 1 time per second.
On the basis of common knowledge of the art, above-mentioned each optimum condition can be combined arbitrarily to get each preferable reality of the present invention Example.
The positive effect of the present invention is that:
The present invention can make patient integrate in primary medical medical diagnosis on disease, critical value early warning and processing, therapeutic scheme The problems such as determining and be integrated, solving repeatedly medical patient, healthcare givers's duplication of labour.
Description of the drawings
Fig. 1 and 2 is that the sleep disturbance of present pre-ferred embodiments detects the structure diagram for the treatment of system.
Fig. 3 is the structural schematic diagram of the mask of present pre-ferred embodiments.
Fig. 4 is the schematic diagram of the alarm module of present pre-ferred embodiments.
Fig. 5 is the sleep analysis figure of present pre-ferred embodiments.
Specific implementation mode
In order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below in conjunction with the embodiment of the present invention In attached drawing, technical scheme in the embodiment of the invention is clearly and completely described, it is clear that described embodiment is A part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art The every other embodiment obtained without making creative work, shall fall within the protection scope of the present invention.
As illustrated in fig. 1 and 2, the present embodiment provides a kind of sleep disturbance to detect treatment system comprising a biological information is remembered Record module 1, an analysis module 2 and an alarm module 3.
The biological information logging modle 1 is used to acquire the various biological informations of doubtful sleep disturbance patient, and those are given birth to Object information is transmitted to the analysis module 2, those biological informations include eeg signal, electro-ocular signal, masseter electromyography signal, lower chin Flesh electromyography signal, mentalis electromyography signal, sound of snoring vibration frequency signal, thorax abdomen fluctuating signal, body position signal, respiratory air flow Pressure signal, blood oxygen saturation and electrocardiosignal.
Wherein, which is acquired by eeg recording electrode, which is acquired by eye electrographic recording electrode, The masseter electromyography signal is acquired by masseter recording electrode, which is acquired by lower mentalis recording electrode, should Mentalis electromyography signal is acquired by chin recording electrode, which is acquired by sound of snoring recording electrode, the chest and abdomen Portion's fluctuating signal is acquired by chest and abdomen belt sensor, which is acquired by body position sensor, the tidal air Flowing pressure signal is by breathing current meter acquisition, and the blood oxygen saturation is by referring to the acquisition of arteries and veins oxygen detection and the electrocardiosignal It is acquired by electrocardioscanner, which is placed in the cardioelectric monitor electrode of the electrocardioscanner.Each record dress The recording frequency set is 1 time per second.
The analysis module 2 is used for the data that confluence analysis biological information logging modle 1 acquires, and sleep was divided into for three stages: Diagnostic phases, titration phase, treatment stage.
Biological information is calibrated first, biological information under patient awoke's state is recorded before patient enters sleep state Foundation level provides basic data foundation for diagnosis.Calibration data include:Eegαwave, respiratory air flow pressure amplitude, oxygen saturation Spend base value.It turns off the light after calibration and starts hypnograph, record frame number of turning off the light is that diagnostic period starts.It is small that diagnostic phases at least continue 2 When more than, reach diagnostic criteria i.e. automatically into titration phase, the switch 41 on titration phase mask 4 automatically turns on (see Fig. 3), Mask is become closed from opening and is stepped up to oxygen concentration or flow, and biological information record reaches certain standard and enters treatment Stage, treatment stage are ended in awake from patient's morning and are rung the doorbell, and machine is turned on light automatically.
The analysis module 2 is that a frame is analyzed with 30s, is divided into patient's states clearly by brain electricity, eye electricity, electromyography signal Awake, NREM phases and REM phases, and the NREM phases are divided into I, II, III, IV phase;Data are for reporting Sleep latency and each rank herein Section sleep quality.Sleep latency=(record frame number-of falling asleep, which is turned off the light, records frame number)/2, unit is minute.
Diagnostic phases need total time in analyzing and diagnosing stage, REM times phase, NREM each times phase.Diagnostic phases total time= (titration phase initial frame number-turn off the light frame number)/2, unit is minute;It is REM times phase=diagnostic phases REM phase frames summation/2, single Position is minute;Awake frame summation/2 after awake total time=diagnostic phases are fallen asleep after sleep, the time is minute;NERM each times phase Each phase frames of=diagnostic phases NERM summation/2, unit is minute.NERM total times phase are from which further followed that by analyzing data above, are examined Disconnected stage sleep total time, Sleep efficiency, sleep histogram.Each time phase adductions of NERM total times phase=diagnostic phases NERM, Time is minute;Diagnostic phases are slept total time=NERM total times phase total time phase+REM, and unit is minute;Sleep efficiency= Diagnostic phases are slept total time/diagnostic phases total time %.
Diagnostic phases are by recording oxygen saturation signal in sleep procedure, mouth and nose stream pressure signal, chest and abdomen movement letter Number, sound of snoring frequency signal for diagnosis report and discriminate whether triggering the titration treatment stage.Diagnosis need to calculate AHI (sleep-respiratories Suspend low ventilation index) the diagnostic phases total time of=low pass gas number × 60/, unit is time/hour.Low pass gas is defined as analyzing 30% or more of sleeping time (NREM phases and REM phases) the interior generation respiratory air flow pressure signal decline scaled values of module record is simultaneously Decline simultaneously with blood oxygen saturation and be more than or equal to scaled values 4%, the duration is more than or equal to 10 seconds.AI (sleep apneas Index)=sleep diagnostic phases the total time of suspending count × 60/, unit is time/hour.Sleep apnea is defined as analysis mould 80% or more that respiratory air flow pressure signal decline scaled values occur in the sleeping time (NREM phases and REM phases) of block record is simultaneously same When with blood oxygen saturation decline be more than or equal to scaled values 4%, the duration be more than or equal to 10 seconds.2 is small after diagnostic phases start When post analysis module start calculate AHI, hereafter calculate AHI per hour.
Such as automatic measurement & calculation AHI<5 times/hour, then do not trigger titration phase.Until measuring and calculating AHI≤5 time/hour, then trigger Reponse system enters titration phase;It is as equal in calculated AHI every time<5 times/hour, then until patient is awake and rings the doorbell, machine is opened automatically Lamp, record are automatically stopped.As automatic measurement & calculation AHI≤5 time/hour, then directly triggering enter titration phase.
Analysis module analyzes diagnostic phases record information, there is following situation:1、AHI<5 times/hour, are defined as nothing Sleep apnea;2,5 times/ little Shi≤AHI<20 times/hour are defined as hypophypnosis apnea;3,20 times/ little Shi≤ AHI<40 times/hour are defined as moderate sleep apnea;AHI40≤secondary/hour is defined as moderate sleep apnea.
It can be obtained in conjunction with chest and abdomen motor message, sound of snoring frequency signal as given a definition:1, AHI≤5 time/hour, and low pass gas Event is synchronous with the sound of snoring when occurring and chest and abdomen movement exists, and is defined as obstructive sleep apnea;2, AHI≤5 time/hour, And and chest and abdomen synchronous with sound of snoring movement disappears when the generation of low pass gas event, is defined as centric sleep apnea;3、AHI≧5 Secondary/hour, low pass gas event is synchronous with the sound of snoring when occurring and chest and abdomen movement disappears, and chest and abdomen movement restores prior to ventilation, is defined as Mixed sleep apnea.When blood oxygen declines when the sound of snoring 4, is recorded, amplitude of respiration decline does not constitute low pass gas standard, definition For benign snoring.
Body position is lateral position, dorsal position or prone position when body position signal records patient sleeps, is calculated separately Low pass gas number, which occurs, for different positions can show that one gives a definition:AHI≤5 time/hour, horizontal position AHI≤2 times lateral position AHI, side Jian≤1 hour clinostatism Shui dormancy Shi, lateral position AHI<15 times/hour are defined as orthostatic sleep apnea.Above-mentioned mark is not achieved Criterion is non-orthostatic.
Titration phase, treatment stage record and analyze the total time in stage, REM times phase, NREM each times phase etc., calculating side The same diagnostic phases of method.Show that data for comparing with diagnostic phases data, assess titration treatment effect.
Analysis module goes out report automatically after treatment is finished.This report is except patient information, check data, record time etc. one As outside information, be divided into diagnostic phases report, titration phase report, treatment stage are reported as three parts.Each section records the stage Total time, REM times phase, NREM times phase, Sleep efficiency, AHI, low pass gas number, sleep apnea number, minimum blood oxygen Intensity value, longest apnea time etc., finally provide diagnosis report.Diagnosis report is only preliminary report data, also needs to cure Teacher combines record data of each phase to analyze, and provides final diagnosis.
As shown in figure 4, the biological information that the alarm module 3 is collected by handling logging modle, examination need emergent management Sleep event prompts attendant physician to be handled by different colours indicator light and jingle bell alarm 31.When the sleep that need to be alarmed Between be defined as follows:1, cardiac monitoring find malignant arrhythmia (electrocardio do not detect, atrial fibrillation, room are quivered, third degree A-V block, Room speed, Torsade de pointes etc.) send out a warning the alarm of 32+ alarms 31;2, blood oxygen saturation<80%, send out a warning 32;3、 80≤blood oxygen saturation < 90%, bright orange lamp 33;3, brain electricity finds epilepsy wave, brilliant blue lamp 34;4, amplitude of respiration or air-flow monitoring Less than brilliant white lamp 35;5, do not occur the above situation, give a green light 36.Above-mentioned five kinds of color indicator lights allow same time point in addition to green light It is bright.
Treatment system is an intelligent CPAP therapy instrument, and analysis system is needed to trigger it, or artificial unlatching.If through dividing Analysis enters titration phase, and treatment system automatically turns on, and patient's mouth and nose pressurization oxygen mask self-closed is initially to oxygen flow 2L/ points, inspiratory/expiratory 1: 1, initial pressure 5.0cmH2O.If measured 5 times/hour of AHI < again, then treatment rank is directly entered Section maintains pressure awake to patient and rings the doorbell, and machine is turned on light automatically, and record is automatically stopped;Such as Reng≤5 beat/min AHI, then automatically Pressure is increased to 7cmH2O, then monitor AHI, Reng≤5 beat/min Ru, continue pressurize 2cmH2O, until measure AHI < 5 times/it is small When, then automatically into treatment stage, maintains the pressure awake to patient and ring the doorbell, machine is turned on light automatically, and record is automatically stopped.It controls Treatment system supports that maximum pressure is 15cmH2O.
A specific example is named to illustrate the present invention, so that those skilled in the art better understood when this The technical solution of invention:
The general information of doubtful sleep disturbance patient (to protect individual privacy, name, admission number have been hidden):
Name Gender:Man Height:182cm Weight:94.0kg
Date of birth:1988/08/07 BMI:28.4kg/m2 Basic blood pressure:124/84mmHg Basal heart rate:80 beats/min
It turns off the light the time:22:58:00 Lighting time:06:03:38 The summary journal time:423 points Total sleep time:284
Sleep latency:27 points Awaken the time:139 points Admission number:
The information of the diagnostic period of doubtful sleep disturbance patient:
It can be analyzed according to information above:
Sleep architecture:Total sleep time is 133 minutes, and Sleep efficiency 73.9%, Sleep architecture is disorderly, is slept shallow, the N3 phases Sleep disappears.
Respiration case:Low pass of sleeping gas-apnea index is 39.0 times/h, the relatively low ventilation of apnea frequency It is more.Blood oxygen situation:Sleep period average oxyhemoglobin saturation 85% reduces more compared with lucid interval average oxyhemoglobin saturation.
Cardiovascular event:No acute cardiovascular event occurs.
The doubtful sleep disturbance patient tentative diagnosis:Based on moderate is obstructive, sleep apnea is with low pass gas.
The drop of patient regularly information:
It can be analyzed according to information above:
(01 after mask closing:58:00), automatic adjustment titration initial pressure is 6cmH2O, and AHI variations in first hour are not Greatly, patient SpO2 fluctuations are larger;(02 at the beginning of second hour:58:00) titration pressure rises to 8cmH2O, patient respiratory suspending count It significantly reduces earlier above, low pass gas number has increased slightly earlier above, and AHI index decreaseds to 21 times/h, SpO2 tend to be steady, in 03:31: 21 are gradually increasing, and then fluctuation is between 93%-99%;(03 at the beginning of third hour:58:00) titration pressure increases again is 10cmH2O, AHI index are down to 8 times/h, and apnea number significantly reduces.Entire titration phase patient sleeps' structure more previous phase Improve, the REM phases, which sleep, increases, Sleep efficiency 97.2%, and awakening number lowers, and the N3 phases occur.
Interpretation of result:Titration treatment pressure regulation 10cmH2O, symptom improve apparent.
The information of the treatment phase of patient:
It can be analyzed according to information above:
10cmH2O pressure, entire treatment phase patient profiles is maintained to tend towards stability, apnea pause, low pass gas number is 10 Secondary/h, blood oxygen saturation maintain 90% or more, and sleep state influences from by morning, and Sleep efficiency reduces earlier above, but when REM sleep Between % increase.
Conclusion:Treating pressure maintains 10cmH2O can notable patients in remission, it is proposed that long-term to maintain.All stage sleeps Analysis chart is shown in Fig. 5.
It is the 50 diagnosis and treatment data of patient tried out the sleep disturbance and detect treatment system below:
Although specific embodiments of the present invention have been described above, it will be appreciated by those of skill in the art that these It is merely illustrative of, protection scope of the present invention is defined by the appended claims.Those skilled in the art is not carrying on the back Under the premise of from the principle and substance of the present invention, many changes and modifications may be made, but these are changed Protection scope of the present invention is each fallen with modification.

Claims (7)

1. a kind of sleep disturbance detects treatment system, which is characterized in that it includes a biological information logging modle and an analysis mould Block;
The biological information logging modle is used to acquire the various biological informations of doubtful sleep disturbance patient, and by those biological informations It is transmitted to the analysis module, those biological informations include eeg signal, electro-ocular signal, masseter electromyography signal, lower mentalis myoelectricity Signal, mentalis electromyography signal, sound of snoring vibration frequency signal, thorax abdomen fluctuating signal, body position signal, respiratory air flow pressure letter Number, blood oxygen saturation and electrocardiosignal;
Each Phase patient's state is divided into waking state, NREM phases and REM by the analysis module for the biological information based on acquisition Phase, and the NREM phases are divided into I, II, III, IV phase, and by the eegαwave under patient awoke's state of acquisition, respiratory air flow pressure Amplitude, blood oxygen saturation base value are as scaled values;
60/ diagnostic phases total times of AHI=low pass gas numbers * are calculated, low pass gas is defined as breathing in NREM phases and REM phases Stream pressure signal, which declines 30% or more of scaled values and declines simultaneously with blood oxygen saturation, is more than or equal to scaled values 4%, holds The continuous time is more than or equal to 10 seconds;
Judge whether AHI is more than a setting number, triggered when to be and enter titration phase, titration phase mask is become from opening Closed and step up to oxygen concentration or flow, the biological information of record reaches certain standard and enters treatment stage, treatment stage It ends in awake from patient's morning.
2. sleep disturbance as described in claim 1 detects treatment system, which is characterized in that the analysis module remembers diagnostic phases Record information is analyzed, AHI<5 times/hour, are defined as non-apnea;5 times/hour≤AHI<20 times/hour, definition For hypophypnosis apnea;20 times/hour≤AHI<40 times/hour are defined as moderate sleep apnea;AHI >=40 time/ Hour, it is defined as severe sleep apnea.
3. sleep disturbance as claimed in claim 2 detects treatment system, which is characterized in that AHI >=5 time/hour, and low pass gas Event is synchronous with the sound of snoring when occurring and chest and abdomen movement exists, and is defined as obstructive sleep apnea;AHI >=5 time/hour, and Low pass gas event is synchronous with the sound of snoring when occurring and chest and abdomen movement disappears, and is defined as centric sleep apnea;AHI >=5 time/small When, low pass gas event is synchronous with the sound of snoring when occurring and chest and abdomen movement disappears, and chest and abdomen movement restores prior to ventilation, is defined as Combination Sleep apnea;When blood oxygen declines when the sound of snoring is recorded, amplitude of respiration decline does not constitute low pass gas standard, it is defined as benign beat Snore.
4. sleep disturbance as claimed in claim 2 detects treatment system, which is characterized in that body position signal record patient sleeps Body position is lateral position, dorsal position or prone position when dormancy, and calculating separately different positions generation low pass gas numbers can obtain: AHI >=5 time/hour, horizontal position AHI >=2 times lateral position AHI, lateral position sleeping time >=1 hour, lateral position AHI<15 times/small When, it is defined as orthostatic sleep apnea;It is non-orthostatic that above-mentioned standard, which is not achieved, then.
5. sleep disturbance as described in claim 1 detects treatment system, which is characterized in that the sleep disturbance detects treatment system It further include an alarm module;The alarm module is used to, according to each biological information, the sleep event for needing emergent management is screened, by not It is handled with color indicator light and jingle bell alarm prompt attendant physician;
The sleeping time that need to be alarmed is defined as follows:Cardiac monitoring finds malignant arrhythmia, and send out a warning simultaneously alarm equipment alarm;Blood oxygen Saturation degree<80%, it sends out a warning;80≤blood oxygen saturation<90%, bright orange lamp;Brain electricity finds epilepsy wave, brilliant blue lamp;Amplitude of respiration Or air-flow monitoring is less than brilliant white lamp;Do not occur the above situation, gives a green light;Above-mentioned five kinds of color indicator lights allow together in addition to green light When light.
6. sleep disturbance as described in claim 1 detects treatment system, which is characterized in that the eeg signal is remembered by brain electricity Electrode acquisition is recorded, which is acquired by eye electrographic recording electrode, which is acquired by masseter recording electrode, The lower mentalis electromyography signal is acquired by lower mentalis recording electrode, which is acquired by chin recording electrode, the snore Sound vibration frequency signal is acquired by sound of snoring recording electrode, which is acquired by chest and abdomen belt sensor, the body Body position signal is acquired by body position sensor, which is acquired by breathing current meter, the blood oxygen Saturation degree is acquired by referring to the acquisition of arteries and veins oxygen detection and the electrocardiosignal by electrocardioscanner, the body position sensor It is placed in the cardioelectric monitor electrode of the electrocardioscanner.
7. sleep disturbance as claimed in claim 6 detects treatment system, which is characterized in that the recording frequency of each recording device is 1 time per second.
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