CN106872379B - A kind of urinary fractions analyzer - Google Patents
A kind of urinary fractions analyzer Download PDFInfo
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- CN106872379B CN106872379B CN201710087690.2A CN201710087690A CN106872379B CN 106872379 B CN106872379 B CN 106872379B CN 201710087690 A CN201710087690 A CN 201710087690A CN 106872379 B CN106872379 B CN 106872379B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/493—Physical analysis of biological material of liquid biological material urine
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Abstract
A kind of urinary fractions analyzer, is able to carry out the detection of a variety of urinary fractions, comprising: the first judging unit, optical detecting unit, second judgment unit storage unit and control unit；Storage unit stores the relation data between the detectable concentration of several special components relevant to the first special component and the first special component and the detectable concentration of the relevant several special components of the first special component；When the testing result of the first special component is positive, control unit is according to the detectable concentration and relation data of the first special component, it calculates and is compared the actually detected concentration of the relevant several special components of the first special component with detectable concentration is expected, determined whether that optical detecting unit and second judgment unit is allowed to work according to comparison result.
Description
Technical field
The present invention relates to a kind of urinary fractions measuring instruments.
Background technique
As the improvement of people's living standards, health is more and more particularly paid attention to.People are important to note that health care, at any time
It checks, grasps health and state of an illness dynamic.In various detection methods, urine detection is convenient due to noninvasive, and can be for being permitted
More medical conditions are checked, and are widely used as a kind of conventional medical detection mode.
Urine is by certain blood constituents by renal glomerular filtration, and reabsorption, set, excretion are formed.
Clinical uroscopy can directly help doctor to understand the urinary physiology function of sufferer and the variation of pathologic function, can also be indirect
Reflect the function situation of organs and system.
Clinic urine test both at home and abroad is very universal, and many and renal function is cardiovascular, metabolic disease, the related field such as infection disease
Inspection need to be carried out with urine.Conventional urine test includes multiple projects, such as: glucose (GLU), bilirubin (BIL), urine
Gallbladder original (URO), ketoboidies (KET), leucocyte (LEC), nitrite (NIT), protein (PRO), pH value (pH), occult blood
(BLD) and specific gravity (SG) etc..
The urine test technology that the country applies at present is mainly chemical analysis system, and the position of the test material material sample containing reagent is put
Urine is set, finds out the colour developing degree of the reagent as optical using optical device using urine and reagent color reaction
Numerical value can find out the concentration of the special component in urine hereby based on the numerical value.
Currently, chemical analysis system has that following specificity is not high, such as in bilirubin measurement, tested
Person may also can generate metachromasia when being given the medicaments such as iobenzamic acid, Etodolac or Epalrestat, lead to false positive
Occur；For example, in creatinine measurement, vitamin C, acetone, acetoacetate, ethyldopa and high concentration glucose, protein
Generation discoloration can be also reacted with reagent picrate with some antibiotic such as benzyl penicillin, Cefoxitin, cephazoline etc., from
And lead to false positive.
In order to improve the reliability of measurement result, 201180026594.8 patent of invention proposes a kind of urinalysis side
Method and analytical equipment have the sun that the special component can be carried out based on the chromogenic reaction of special component and reagent in urine
Property and negative difference the first judgement judging unit；Suction of the urine itself relative to the light in provision wavelengths domain can be found out
The optical detecting unit of the data of light characteristic, the data of extinction characteristic be in regulation in the range of and it is described first judgement knot
When fruit is the scheduled side in positive and feminine gender, judging unit be changed to the result that described first judges pseudo- positive or pseudo-
Second judgement negative or a possibility that be judged as in the presence of pseudo- positive or under-referral.I.e. in the invention to positive findings again into
Row one-shot measurement determines, so that it is determined that the case where being judged as in the result of the positive with the presence or absence of false positive.
201180026594.8 invention improves the reliability of measurement result, but it needs to measure for each
Positive findings carry out an optical measurement more, then determine whether false positive again, increase pendulous frequency, have aggravated measurement
Complexity.
Summary of the invention
As one aspect of the present invention, a kind of urinary fractions measuring instrument is provided, a variety of urinary fractions are able to carry out
Detection, comprising: the first judging unit, for the chromogenic reaction according to the first special component and reagent in urine, determine this
One special component is negative or positive；Optical detecting unit can find out the urine not reacted with the reagent relative to rule
Determine the data of the extinction characteristic of the light of wavelength domain；Second judgment unit is in particular range, and described in the data
When one judging unit judges first special component for the positive, it is able to carry out the second judgement, second judgement can determine the
True positives or the pseudo- positive when positive for the first special component that one judging unit determines further include that storage unit and control are single
Member；The storage unit stores several special components relevant to first special component, and the storage unit is also for urine
The testing result of liquid ingredient is stored；Described control unit is after the detection of all urinary fractions finishes, when the first judgement is single
When member determines first special component for the positive, described control unit according to stored in storage unit with described first it is specific at
The testing result of point relevant several special components judged, according to judging result decide whether to optical detecting unit and
Second judgment unit work.
Preferably, in above scheme, if in the testing result of the relevant several special components of first special component
There is no the positive, then described control unit controls the optical detecting unit and second judgment unit work, with determine this
One judging unit is true positives or false positive for the positive of first special component.
Preferably, in above scheme, if in the testing result of the relevant several special components of first special component
One or more exist it is positive, then described control unit control the optical detecting unit and second judgment unit not into
Row work, directly the first special component testing result of output are positive report.
As another aspect of the present invention, provide a kind of urinary fractions measuring instrument, be able to carry out a variety of urines at
The detection divided, comprising: the first judging unit determines for the chromogenic reaction according to the first special component and reagent in urine
First special component is negative or positive；Optical detecting unit can be found out not opposite with the urine of reagent reaction
In the data of the extinction characteristic of the light in provision wavelengths domain；Second judgment unit, in the data processing particular range, and institute
When stating the first judging unit and judging first special component for the positive, it is able to carry out the second judgement, second judgement can be true
True positives or the pseudo- positive when positive for the first special component that fixed first judging unit determines, it is characterised in that: further include depositing
Storage unit and control unit；The storage unit stores several special components relevant to first special component, described
Storage unit is stored also for the testing result of urinary fractions；Described control unit all urinary fractions detection finish with
Afterwards, when the first judging unit determines first special component for the positive, the judging unit is according to first special component
Detectable concentration and the detectable concentrations of several special components relevant to the first special component judged, according to judgement
As a result optical detecting unit and second judgment unit work are decided whether to.
Preferably, in above scheme, the storage unit also store the detectable concentration of first special component with it is described
Relation data between the detectable concentration of the relevant several special components of first special component, when the inspection of first special component
When survey result is positive, detectable concentration and the relation data of the described control unit according to first special component, meter
Calculate the expectation detectable concentration of the relevant several special components of first special component, and by the first special component phase
The actually detected concentration of several special components closed is compared with the expectation detectable concentration, is determined whether according to comparison result
Optical detecting unit and second judgment unit is allowed to work.
Preferably, in above scheme, if the relevant several special components of first special component is actually detected dense
Degree and the absolute value of the difference for expecting detectable concentration are respectively less than specific threshold, then described control unit controls the optics and surveys
Without work, directly the first special component testing result of output is positive report for order member and second judgment unit.
Preferably, in above scheme, if the relevant several special components of first special component is actually detected dense
One or more in degree and the absolute value of the difference for expecting detectable concentration is greater than specific threshold, then described control unit
Control the optical detecting unit and second judgment unit work, with determine first judging unit for this first it is specific at
The positive divided is true positives or false positive.
It preferably, further include output device in above scheme, the output device is negative, positive or false for exporting
Positive testing result.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of urinary fractions measuring instrument of the invention.
Specific embodiment
In order to illustrate more clearly of technical solution of the present invention, embodiment will be used simply to be situated between the present invention below
Continue, it should be apparent that, be described below in be only one embodiment of the present of invention, for those of ordinary skill in the art come
It says, without any creative labor, other technical solutions can also be obtained according to these embodiments, also belonged to
Disclosure of the invention range.
Embodiment one
Referring to Fig. 1, the present invention provides a kind of urinary fractions measuring instrument for being able to carry out a variety of urinary fractions detections, this
A little urinary fractions include but is not limited to glucose, bilirubin, urobilinogen ketoboidies, urine enzyme, leucocyte, nitrite, protein, acid
Basicity, occult blood.The measuring instrument includes optical detecting unit, the first judging unit, second judgment unit, storage unit, and control is single
Member.
First judging unit, for the chromogenic reaction according to the first special component and reagent in urine, determine this first
Special component is negative or the positive, and the judgment criteria in the prior art for chromogenic reaction can be used.These reagents and
Reaction is reaction test type well known in the prior art, such as bilirubin is reacted with diazo reagent, and creatinine and picrate try
Agent reaction etc..
It is special relative to the extinction of the light in provision wavelengths domain that optical detecting unit can find out the urine not reacted with the reagent
The data of property.It can be used in the prior art, such as the optical detecting unit in the embodiment of 201180026594.8 inventions.
Second judgment unit is in particular range in the data, and first judging unit judge this first
When special component is positive, it is able to carry out the second judgement, second judgement can determine the first judging unit determines first
True positives or the pseudo- positive when positive of special component.The reality such as 201180026594.8 inventions can be used in second judgment unit
The method for applying the second judgement in example carries out true positives or pseudo- positive judgement.
The principle of the embodiment of the present invention is, in urine test, many measurement ingredients the result is that relevant, such as
Detection for bilirubin and urine enzyme (NAG, GAL, ALP, GGT, LDH), when injury of kidney, usual bilirubin is increased also along with urine
The raising of enzyme, but the detection reagent of different measurement ingredients is different.It therefore, can in the detection of urinary fractions such as bilirubin
To judge whether to secondary judgement by the observation of the testing result for its Related Component.If measuring ingredient and Qi Guan
The trend being unified into point is consistent, and is indicated that there is no problem for the measurement, is not then needed to carry out the second judgement again, if the measurement at
Point be associated with ingredient trend be it is inconsistent, indicating the measurement, there may be problems, then should carry out the second judgement.Pass through
This mode, it is possible to reduce carry out the number of double measurement and judgement.
Therefore, in the embodiment of the present invention, setting for storage unit and control unit is for the contribution of the prior art
It sets.Storage unit stores the title of relevant to first special component several special components, for example, bilirubin and and its
Relevant urine enzyme.Storage unit is stored also for the testing result of urinary fractions.Control unit is examined in all urinary fractions
After survey finishes, when the first judging unit determines the testing result of the first special component such as bilirubin for the positive, control
Unit judges for urinating the testing result of enzyme, if the testing result of urine enzyme is feminine gender, then it represents that the detection knot of bilirubin
There may be problems for fruit, and at this moment control unit controls the optical detecting unit and second judgment unit work, is somebody's turn to do with determining
First judging unit is true positives or false positive for the positive of first special component.On the other hand, if urine enzyme detection
Result be also the presence of the positive, then it represents that the testing result of bilirubin be it is reliable, control unit controls the optical detecting list
Without work, the testing result of directly output bilirubin is positive report for member and second judgment unit.
Embodiment two
The embodiment of the present invention two provides a kind of urinary fractions measuring instrument, is able to carry out the inspection of a variety of urinary fractions
It surveys, comprising: the first judging unit, optical detecting unit, the first judging unit, second judgment unit, storage unit, control are single
Member.
First judging unit is used for the chromogenic reaction according to the first special component and reagent in urine, determines first spy
It is negative or positive for determining ingredient.Optical detecting unit can find out the urine not reacted with the reagent relative to regulation wave
The data of the extinction characteristic of the light in long domain.Second judgment unit, in the data processing particular range, and described first sentences
When disconnected unit judges first special component is positive, it is able to carry out the second judgement, second judgement can determine that first sentences
True positives or the pseudo- positive when positive for the first special component that disconnected unit determines.
Storage unit, the storage unit stores several special components relevant to first special component, described to deposit
Storage unit is stored also for the testing result of urinary fractions, and the storage unit also stores the inspection of first special component
Survey the relation data between the detectable concentration of concentration several special components relevant to first special component, such as bilirubin
With the concentration linear relationship data of urine enzyme.
Control unit, described control unit is after the detection of all urinary fractions finishes, when first special component
When testing result is positive, described control unit according to the detectable concentration and the relation data of first special component,
Calculate the expectation detectable concentration of the relevant several special components of first special component, and by first special component
The actually detected concentration of relevant several special components is compared with the expectation detectable concentration.If described first it is specific at
The absolute value of the actually detected concentration and the difference for expecting detectable concentration of dividing relevant several special components is respectively less than specific
Threshold value, then described control unit controls the optical detecting unit and second judgment unit without work, directly output the
One special component testing result is positive report.If the practical inspection of the relevant several special components of first special component
One or more surveyed in the absolute value of concentration and the difference for expecting detectable concentration is greater than specific threshold, the then control
Unit controls the optical detecting unit and second judgment unit work, to determine first judging unit for first spy
The positive for determining ingredient is true positives or false positive.
The difference of second embodiment and first embodiment is, has carried out further optimization.Due to different in urine
The positive threshold value of the testing result measurement of ingredient is different, such as when bilirubin is positive, although urine enzyme values also with raising,
Reach the positive Near Threshold of urine enzyme values, but be not above the positive threshold value of urine enzyme values, in this case in the first embodiment
Then it is judged as and needs to carry out the second judgement.But it urinates actually having built up for enzyme values and has shown exception.Therefore, second
In embodiment, the relation data of the first special component and relative special component is stored in the storage device, such as
The concentration linear relationship data of bilirubin and urine enzyme, it is linear by the concentration when the first special component testing result is positive
Relation data calculates the expected value of Related Component, is judged whether to need secondary survey according to the offset of the expected value and measured value
Amount.By the qualitative judgement of first embodiment i.e. in second embodiment, it is optimized for quantitative judgement, to improve the standard of judgement
True property.
All references mentioned in the present invention all incorporated by reference in this application, are individually recited just as each document
As with reference to such.In addition, it should also be understood that, after reading the above teachings of the present invention, those skilled in the art can be right
The present invention makes various changes or modifications, and these equivalent forms also fall within the scope of the appended claims of the present application.
Claims (1)
1. a kind of urinary fractions measuring instrument, is able to carry out the detection of a variety of urinary fractions, comprising: the first judging unit is used for
According to the chromogenic reaction of the first special component and reagent in urine, determine that first special component is negative or positive；Light
Determination unit is learned, the number of the urine that does not react with the reagent relative to the extinction characteristic of the light in provision wavelengths domain can be found out
According to；Second judgment unit, in the data processing particular range, and first judging unit judge this first it is specific at
When being divided into the positive, be able to carry out the second judgement, second judgement can determine the first judging unit determines first it is specific at
The positive divided is true positives or the pseudo- positive, it is characterised in that: further includes storage unit and control unit；The storage is single
Member stores several special components relevant to first special component, detection knot of the storage unit also for urinary fractions
Fruit is stored；The detectable concentration that the storage unit also stores first special component is related to first special component
Several special components detectable concentration between relation data, when the testing result of first special component is positive,
It is specific to calculate described first according to the detectable concentration and the relation data of first special component for described control unit
The expectation detectable concentration of the relevant several special components of ingredient;If the relevant several special components of first special component
Actually detected concentration and the absolute value of difference for expecting detectable concentration be respectively less than specific threshold, then described control unit control
The optical detecting unit and second judgment unit are made without work, directly the first special component testing result of output is sun
The report of property；If the actually detected concentration of the relevant several special components of first special component and expectation detection are dense
One or more in the absolute value of the difference of degree is greater than specific threshold, then described control unit controls the optical detecting list
Member and second judgment unit work, with determine first judging unit for the positive of first special component be true positives also
It is false positive；First special component is bilirubin, includes urine enzyme in several special components.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710087690.2A CN106872379B (en) | 2015-05-16 | 2015-05-16 | A kind of urinary fractions analyzer |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710087690.2A CN106872379B (en) | 2015-05-16 | 2015-05-16 | A kind of urinary fractions analyzer |
| CN201510248699.8A CN104819981B (en) | 2015-05-16 | 2015-05-16 | A kind of urinary fractions measuring instrument |
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| CN201510248699.8A Division CN104819981B (en) | 2015-05-16 | 2015-05-16 | A kind of urinary fractions measuring instrument |
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| CN106872379B true CN106872379B (en) | 2019-08-27 |
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| CN201510248699.8A Expired - Fee Related CN104819981B (en) | 2015-05-16 | 2015-05-16 | A kind of urinary fractions measuring instrument |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110678734B (en) * | 2017-06-29 | 2023-09-12 | 深圳迈瑞生物医疗电子股份有限公司 | Blood testing method and apparatus |
| CN107807162A (en) * | 2017-09-28 | 2018-03-16 | 珠海沃姆电子有限公司 | Urine parameters detection means and urine parameters monitoring system |
| CN108957018A (en) * | 2018-05-19 | 2018-12-07 | 贾晓轻 | A kind of automatic biochemistry analyzer |
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| CN101074914A (en) * | 2006-05-18 | 2007-11-21 | 希森美康株式会社 | Apparatus for analyzing particles in urine and method thereof |
| CN101968493A (en) * | 2009-07-24 | 2011-02-09 | 霍夫曼-拉罗奇有限公司 | A urine work area manager and a urine work area |
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| CN102680701A (en) * | 2012-04-27 | 2012-09-19 | 嘉兴九七九生物技术有限公司 | Quantitative detection reagent and quantitative detection method for urinary protein liquid |
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| JPH0244396B2 (en) * | 1982-12-29 | 1990-10-03 | Nippon Shoji Kk | BIRIRUBINTEIRYOHO |
| TW591230B (en) * | 1997-10-14 | 2004-06-11 | Bayer Ag | Method for improving the accuracy of the semi-quantitative determination of analyte in fluid samples |
| CN1727902A (en) * | 2003-09-04 | 2006-02-01 | 合肥新月电子技术有限责任公司 | Full-automatic urine analysis system |
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| WO2009134887A1 (en) * | 2008-04-30 | 2009-11-05 | Instrumentation Laboratory Company | Hemoglobin based bilirubin reference material |
| JP5351585B2 (en) * | 2009-03-31 | 2013-11-27 | シスメックス株式会社 | Kidney disease diagnosis support device and computer program |
| JP5591619B2 (en) * | 2010-08-03 | 2014-09-17 | シスメックス株式会社 | Urine test apparatus and urine sample measurement result processing apparatus |
| JP5964813B2 (en) * | 2011-03-24 | 2016-08-03 | シスメックス株式会社 | Sample analyzer, sample information processing apparatus, and sample analysis method |
| CA2846106C (en) * | 2011-08-26 | 2020-09-01 | Alan Marc Kleinfeld | Development and use of fluorescent probes of unbound bilirubin |
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- 2015-05-16 CN CN201510248699.8A patent/CN104819981B/en not_active Expired - Fee Related
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101074914A (en) * | 2006-05-18 | 2007-11-21 | 希森美康株式会社 | Apparatus for analyzing particles in urine and method thereof |
| CN101968493A (en) * | 2009-07-24 | 2011-02-09 | 霍夫曼-拉罗奇有限公司 | A urine work area manager and a urine work area |
| CN102918393A (en) * | 2010-06-02 | 2013-02-06 | 爱科来株式会社 | Urine analysis method, device thereof, program used in urine analysis method, and storage medium thereof |
| CN102680701A (en) * | 2012-04-27 | 2012-09-19 | 嘉兴九七九生物技术有限公司 | Quantitative detection reagent and quantitative detection method for urinary protein liquid |
| CN102662048A (en) * | 2012-05-21 | 2012-09-12 | 长沙高新技术产业开发区爱威科技实业有限公司 | Method and device for analyzing urine |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104819981A (en) | 2015-08-05 |
| CN106872379A (en) | 2017-06-20 |
| CN104819981B (en) | 2017-11-21 |
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