CN106063712B - A kind of ultrasonic medical method and system - Google Patents
A kind of ultrasonic medical method and system Download PDFInfo
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- CN106063712B CN106063712B CN201610349799.4A CN201610349799A CN106063712B CN 106063712 B CN106063712 B CN 106063712B CN 201610349799 A CN201610349799 A CN 201610349799A CN 106063712 B CN106063712 B CN 106063712B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
- A61B8/0833—Detecting organic movements or changes, e.g. tumours, cysts, swellings involving detecting or locating foreign bodies or organic structures
- A61B8/085—Detecting organic movements or changes, e.g. tumours, cysts, swellings involving detecting or locating foreign bodies or organic structures for locating body or organic structures, e.g. tumours, calculi, blood vessels, nodules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N7/00—Ultrasound therapy
- A61N7/02—Localised ultrasound hyperthermia
Abstract
This application discloses a kind of ultrasonic medical method and system, the system comprises: multiple biological signal processors, ultrasonic transmitting device and central processor equipment；Biological signal processor calculates the difference of bio signal of the target spot of positioning before and after difference frequency ultrasound stimulation, generate the first index variable quantity, and target spot carries out the bio signal after difference frequency ultrasound stimulation difference before difference frequency ultrasound stimulation and after ablation is calculated, generate the second index variable quantity；Central processor equipment sends corresponding instruction to ultrasonic transmitting device according to the comparison result and the second index variable quantity of the first index variable quantity and the first pre-set level variable quantity and the comparison result of the second pre-set level variable quantity, wherein, instruction includes that target spot positioning instruction and difference frequency ultrasound stimulation instruct, with the instruction of frequency supersonic melting or the instruction of difference frequency supersonic melting, the diagnosis to positioning target spot and the assessment of ablation effect are realized, to realize the integration and automation of diagnosis and treatment.
Description
Technical field
The present invention relates to the field of medical instrument technology, more specifically to a kind of ultrasonic medical method and system.
Background technique
High intensity focused ultrasound (High-intensity focused ultrasound, HIFU) is a kind of based on ultrasound
The noninvasive laser therapy technology of good targeting, convergence property and the physical features such as penetrability, the technology is by low energy densities
Ultrasonic energy is focused by emitting in vitro through internal target area is reached after skin and respective organization, forms the high coke of energy density
Point, and the biological effects such as fuel factor, cavitation effect and mechanical effect by generating, make target area histocyte in a short time
Coagulation necrosis occurs, and does not damage on sound channel and target area surrounding tissue even seldom, to reach noninvasive ablation or excision
The purpose of pathological tissues.HIFU technology has been widely used the treatment of clinical innocent and malignant tumour, and the technology in recent years
It is extended to the non-tumor area such as neurology and cardiology.
In current treatment, the determination of destination organization mainly passes through iconography image and guides, and determines destination organization
Behind target area, target spot is selected according to the experience of doctor, directly target spot is melted using HIFU technology later, is not had to ablation effect
There is the corresponding method of assessment, in addition, depending on the subjective judgement of doctor for the diagnosis of the target spot in target area, there are blindness.
Therefore, a kind of target spot to positioning how is provided to carry out diagnosis and the method for assessing ablation effect and be
System, is those skilled in the art's technical problem urgently to be resolved.
Summary of the invention
In order to solve the above technical problems, the present invention provides a kind of ultrasonic wave diagnosis and treatment method and system, to realize to positioning
The purpose that target spot carries out diagnosis and ablation effect is assessed.
To achieve the above object, the invention provides the following technical scheme:
A kind of ultrasonic medical system, the system, comprising: multiple biological signal processors, ultrasonic transmitting device and
Central processor equipment；
Multiple biological signal processors exist for calculating the target spot of ultrasonic transmitting device positioning of acquisition
The difference of bio signal before and after difference frequency ultrasound stimulation generates the first index variable quantity；And the target spot of acquisition is calculated in difference
The difference that the bio signal after difference frequency ultrasound stimulation is carried out before frequency ultrasound stimulation and after ablation generates the second index variable quantity, and
The first index variable quantity and the second index variable quantity are sent to the central processor equipment；
The ultrasonic transmitting device, for according to the imaging instruction that receives to the transmitting of organism destination organization target area at
As ultrasonic wave, and the ultrasonic reflections signal of feedback is sent to the central processor equipment；And it is set based on the central processing
The corresponding instruction execution corresponding operation that preparation is sent；
The imaging instruction is simultaneously sent to described by the central processor equipment, the imaging instruction for receiving input
Ultrasonic transmitting device, and the ultrasonic reflections signal of the ultrasonic transmitting device feedback is received, generate image information；
First pre-set level variable quantity of the first index variable quantity and input that are sent according to the biological signal processor
Second pre-set level of the second index variable quantity and input that comparison result and the biological signal processor are sent
The comparison result of variable quantity sends corresponding instruction to the ultrasonic transmitting device respectively, until completing disappearing for all target spots
Melt, wherein described instruction includes target spot positioning instruction and difference frequency ultrasound stimulation instruction, with the instruction of frequency supersonic melting or difference frequency ultrasound
Ablation instruction.
Preferably, the biological signal processor, comprising: multiple biological signal collecting devices, and with it is multiple described
Biological signal collecting device corresponds the multiple bio signal processing units being connected；
The biological signal collecting device, for acquiring first bio signal of the target spot before difference frequency ultrasound stimulation, in institute
Third bio signal of the target spot after the second bio signal and ablation after difference frequency ultrasound stimulation after stating difference frequency ultrasound stimulation,
And first bio signal, second bio signal and the third bio signal are sent to the bio signal and handled
Device；
The bio signal processing unit generates the first finger for carrying out processing to first bio signal received
Scale value carries out processing the second index value of generation to second bio signal received and the third life to receiving
Object signal carries out processing and generates third index value, and calculates the difference of first index value and second index value, obtains
First index variable quantity, and the difference of first index value and the third index value is calculated, obtain the variation of the second index
Amount, and the first index variable quantity and the second index variable quantity are sent to central processor equipment.
Preferably, when the biological signal collecting device includes: electrode slice, the bio signal processing unit includes:
Electrocardiograph analyzer, respiration monitor and/or electroencephalograph；
When the biological signal collecting device includes: pressure transducer, the bio signal processing unit includes: physiology
Recorder；
When the biological signal collecting device includes: neuropotential probe, the bio signal processing unit includes: mind
Through potentiometric analyzer；
When the biological signal collecting device includes: blood biochemical signal probe, the bio signal processing unit packet
It includes: seralyzer.
Preferably, the ultrasonic transmitting device, comprising: ultrasonic imaging driving device, ultrasonic driving apparatus and phased
Battle array joint probe；
The ultrasonic imaging driving device, for controlling the phased array joint probe hair according to the imaging instruction received
Ultrasonic imaging signal is penetrated, and the ultrasonic reflections signal received is sent to central processor equipment；
The ultrasonic driving apparatus, target spot positioning instruction and difference frequency ultrasound stimulation instruction for will receive, with frequency
Supersonic melting instruction or the instruction of difference frequency supersonic melting are sent to the phased array joint probe；
The phased array joint probe, for super to the transmitting imaging of organism destination organization target area according to the imaging instruction
Sound wave, and the ultrasonic reflections signal of feedback is sent to the ultrasonic imaging driving device, and based on corresponding described
Target spot positioning instruction is moved to corresponding target spot to be positioned, is instructed based on the difference frequency ultrasound stimulation to the target spot and emits difference frequency
Ultrasound is stimulated, and is instructed based on the instruction of same frequency supersonic melting or difference frequency supersonic melting to the target spot and emitted with frequently or poor
Frequency ultrasound is melted.
Preferably, the ultrasonic imaging driving device includes:
Ultrasonic imaging driving unit, for receiving the imaging instruction of central processor equipment transmission, and by the imaging instruction
It is sent to phased array joint probe；
Signal processing unit combines what probe was scanned organism destination organization target area for receiving the phased array
Ultrasonic reflections signal, and it is transmitted to the central processor equipment.
Preferably, the phased array joint probe includes:
Phased array supersonic imaging probe, the imaging instruction for being sent according to the ultrasonic imaging driving unit is to institute
It states the organism destination organization target area transmitting imaging ultrasound wave to be scanned, and the ultrasonic reflections signal of feedback is sent out
Give the signal processing unit；
Wherein, the arrangement mode of the phased array supersonic imaging probe includes: linear array, two-dimensional rectangle array, circle
Array or spherical array；
Phase array transducer array, for receiving target spot positioning instruction, the difference that the ultrasonic driving apparatus is sent
Frequency ultrasound stimulation instructs and with the instruction of frequency supersonic melting or the instruction of difference frequency supersonic melting, and according to target spot positioning instruction movement
To corresponding target spot to be positioned, the difference frequency ultrasound is emitted to the target spot according to difference frequency ultrasound stimulation instruction and is pierced
Swash, the target spot is emitted with frequency or difference frequency ultrasound according to the same frequency supersonic melting instruction or difference frequency supersonic melting instruction
It is melted；
Wherein, the phase array transducer array includes multiple equal in magnitude, is worked independently by autonomous channel
Ultrasonic transducer array element, the multiple ultrasonic transducer array element, for being moved according to the positioning instruction in target area, automatically
Target spot is found, and when the target spot occurs mobile, for tracking, position the target spot, and for leading to by the independence
Road emits ultrasonic wave to the target spot, carries out difference frequency ultrasound stimulation to the target spot or carries out the target spot with frequency supersonic melting
Or difference frequency supersonic melting；
And the arrangement mode of multiple ultrasonic transducer array elements include: linear array, annular array, Concentric circle array,
Rectangular array, fan-shaped array or on-demand irregular array.
Preferably, the central processor equipment, comprising:
The imaging instruction is simultaneously sent to the ultrasonic wave hair by central control unit, imaging instruction for receiving input
Jet device, and the ultrasonic reflections signal of the ultrasonic transmitting device feedback is received, generate image information；Receive the finger of input
The the first pre-set level variable quantity and the second index variable quantity for enabling and inputting, and it is sent to feed back control system；
Feed back control system refers to for receiving the first index variable quantity and second that the biological signal processor is sent
Variable quantity is marked, according to the comparison result of the first index variable quantity and the first pre-set level variable quantity received, Yi Jisuo
The comparison result for the second pre-set level variable quantity stating the second index variable quantity and receiving is set to ultrasonic wave transmitting respectively
Preparation send corresponding instruction, until completing the ablation of all target spots；
Wherein, described instruction includes target spot positioning instruction and difference frequency ultrasound stimulation instruction, is instructed with frequency supersonic melting or poor
The instruction of frequency supersonic melting.
Preferably, the central control unit is also used to send the order for releasing or stopping to the feed back control system,
And it substitutes the feed back control system and executes corresponding work；
Correspondingly, the feed back control system, for receiving the instruction of the releasing or stopping, and releases or stops executing
Corresponding work.
Preferably, the ultrasonic transmitting device is also used to receive the life that multiple biological signal processors are sent
Object signal, and the respiratory pause according to the breath signal in the bio signal received in organism emits ultrasonic wave or root
Emit ultrasonic wave in biological systemic heart isovolumic relaxation period or isovolumic contraction period according to the electrocardiosignal in the bio signal received.
A kind of ultrasonic medical method, comprising:
S1: positioning multiple target spots in biological targets tissue target area based on image information and positioning instruction, determines
The target spot of positioning；
S2: the difference of bio signal of the target spot for acquiring the positioning before and after difference frequency ultrasound stimulation is calculated, generates first
Index variable quantity；
S3: judging whether the first index variable quantity reaches the first pre-set level variable quantity, if so, executing step
S4 returns to step S2 if not, navigating to next target spot；
S4: the target spot is emitted and is melted with frequency or difference frequency ultrasound；
S5: it calculates the target spot of acquisition and carries out difference frequency ultrasound stimulation before difference frequency ultrasound stimulation and after target spot ablation
The difference of bio signal afterwards generates the second index variable quantity；
S6: judging whether the second index variable quantity reaches the second pre-set level variable quantity, if so, navigating to next
Target spot executes step S2, if not, executing step S4；Until completing the ablation of all target spots.
Preferably, after judging whether the first index variable quantity reaches the first pre-set level variable quantity, further includes:
If it is, recording to the target spot of the positioning, and next target spot is navigated to, executes step S2；If it is not, then navigating to
Next target spot executes step S2, until recording target spot in need for the treatment of in all investigative ranges；
It is finding in investigative range after target spot in need for the treatment of, to the target spot transmitting in need for the treatment of with frequency or difference frequency
Ultrasound is melted, and is calculated the target spot in need for the treatment of and carried out difference frequency ultrasound stimulation before difference frequency ultrasound stimulation and after ablation
The difference of bio signal afterwards generates the second index variable quantity, and it is pre- to judge whether the second index variable quantity reaches second
If index variable quantity, if it is, determining to melt successfully；If it is not, then being melted again, until completing to control the needs
The ablation of the target spot for the treatment of.
It can be seen from the above technical proposal that a kind of ultrasonic medical method and system provided by the present invention, the system
It include: biological signal processor, ultrasonic transmitting device and central processor equipment.Biological signal processor calculates target spot and exists
The difference of bio signal before and after difference frequency ultrasound stimulation generates the first index variable quantity, and calculates target spot and pierce in difference frequency ultrasound
The difference that the bio signal after difference frequency ultrasound stimulation is carried out before swashing and after ablation, generates the second index variable quantity；Central processing is set
It is standby to determine whether target spot reaches in need for the treatment of according to the comparison result of the first index variable quantity and the first pre-set level variable quantity
Whether degree melts to control ultrasonic transmitting device and emit target spot with frequency or difference frequency ultrasound, and according to second
The comparison result of index variable quantity and the second pre-set level variable quantity determines whether target spot melts success after ablation, to control
Whether ultrasonic transmitting device needs to melt target spot again.It can be seen that this system can be realized the target spot to positioning
Diagnose and after ablation assess ablation effect, to realize the integration and automation of diagnosis and treatment process.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
The embodiment of invention for those of ordinary skill in the art without creative efforts, can also basis
The attached drawing of offer obtains other attached drawings.
Fig. 1 is a kind of structural schematic diagram for ultrasonic medical system that the embodiment of the present invention one provides；
Fig. 2 is the structural representation of biological signal processor in a kind of ultrasonic medical system provided by Embodiment 2 of the present invention
Figure；
The structural representation of ultrasonic transmission device in a kind of ultrasonic medical system that Fig. 3 provides for the embodiment of the present invention three
Figure；
Another structure of ultrasonic transmission device in a kind of ultrasonic medical system that Fig. 4 provides for the embodiment of the present invention three
Schematic diagram；
The composed structure of phased array joint probe in a kind of ultrasonic medical system that Fig. 5 provides for the embodiment of the present invention three
Figure；
The structural schematic diagram of central processor equipment in a kind of ultrasonic medical system that Fig. 6 provides for the embodiment of the present invention four；
Fig. 7 is a kind of flow chart for ultrasonic medical method that the embodiment of the present invention six provides；
Fig. 8 is the schematic diagram for the renal sympathetic nerve target spot plan that application example one of the present invention provides；
Fig. 9 is the schematic diagram for the secretory tumor targets plan that application example two of the present invention provides.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
The embodiment of the invention discloses a kind of ultrasonic medical method and system, with realize positioning to target spot, diagnosis and
The purpose of the assessment of ablation effect.
Embodiment one
The embodiment of the present invention one provides a kind of ultrasonic medical system, as disclosed in the attached embodiment of the present invention one shown in fig. 1
A kind of structural schematic diagram of ultrasonic medical system, the system comprises: multiple biological signal processors 101, ultrasonic wave transmitting
Equipment 102 and central processor equipment 103；
Multiple biological signal processors 101, what the ultrasonic transmitting device 102 for calculating acquisition positioned
The difference of bio signal of the target spot before and after difference frequency ultrasound stimulation generates the first index variable quantity；And calculate the target of acquisition
Point carries out the difference of the bio signal after difference frequency ultrasound stimulation before difference frequency ultrasound stimulation and after ablation, generate the variation of the second index
Amount, and the first index variable quantity and the second index variable quantity are sent to the central processor equipment 103；
The ultrasonic transmitting device 102, for being sent out according to the imaging instruction received to organism destination organization target area
Imaging ultrasound wave is penetrated, and the ultrasonic reflections signal of feedback is sent to the central processor equipment 103；And it is based on the center
The corresponding instruction execution corresponding operation that processing equipment 103 is sent；
It needs to be illustrated, the ultrasonic transmitting device is configured to phase delay technology, dynamic focusing
The equipment of technology, dynamic Apodization techniques and dynamic aperture technology can be realized the dynamic focusing on ultrasonic beam direction, when described
It, can Fast synchronization tracking when target spot occurs mobile；The size of the focal regions of focusing can be changed as needed, realize point, line, surface etc.
The focusing of variform；It positions and treats while realizing multiple target spots further, it is also possible to be focused by many places.
The imaging instruction is simultaneously sent to by the central processor equipment 103, the imaging instruction for receiving input
The ultrasonic transmitting device 102, and the ultrasonic reflections signal that the ultrasonic transmitting device 102 is fed back is received, it is raw
At image information；The first of the first index variable quantity and input that are sent according to the biological signal processor 101 is pre-
If the second index variable quantity that the comparison result of index variable quantity and the biological signal processor 101 are sent and
The comparison result of second pre-set level variable quantity of input sends corresponding instruction to the ultrasonic transmitting device 102 respectively,
Until completing the ablation of all target spots, wherein described instruction includes target spot positioning instruction and difference frequency ultrasound stimulation instruction, with frequently super
Sound ablation instruction or the instruction of difference frequency supersonic melting.
Wherein, image information include but is not limited to M type ultrasonoscopy, it is 2-D gray image, blood flow frequency spectrum image, colored more
General Le image can also include the image information of other forms.
It needs to be illustrated, organism destination organization target area is artificial true under the guidance of described image information
Fixed.After determining the target area, the target area equidistant intervals are divided into many levels, are selected in each level more
Target spot plan of a block as target spot, as formulation.After the target spot plan, Xiang Suoshu central processor equipment
The 103 input target spot plans, the central processor equipment 103 emit according to the target spot plan of input to the ultrasonic wave
Equipment 102 sends target spot positioning instruction, to realize the automatic positioning to target spot.
In addition, to target spot carry out difference frequency ultrasound stimulation and with the intensity of ultrasonic wave of frequency or difference frequency supersonic melting, frequency,
The parameters such as phase are also to be input manually into the central processor equipment 103；Wherein, the pulse spacing of the ultrasonic wave can basis
It needs to be adjusted, the range of duty ratio is 10%-90%.
In the embodiment of the present invention one, the central processor equipment 103 is sent according to the biological signal processor 101
The first index variable quantity and input the first pre-set level variable quantity comparison result and the bio signal processing
The comparison result of second pre-set level variable quantity of the second index variable quantity and input that equipment 101 is sent is respectively to described
Ultrasonic transmitting device 102 sends corresponding instruction, until completing the ablation of all target spots, specifically includes:
When the first index variable quantity reaches the first pre-set level variable quantity, the central processor equipment 103 will be connect
The same frequency supersonic melting instruction or the instruction of difference frequency supersonic melting received is sent to the ultrasonic transmitting device 102；
When the first index variable quantity is not up to the first pre-set level variable quantity, the central processor equipment
The positioning instruction for positioning next target spot and difference frequency ultrasound stimulation instruction are sent to the ultrasonic transmitting device 102 by 103；
When the second index variable quantity is not up to the second pre-set level variable quantity, the central processor equipment
The same frequency supersonic melting instruction or the instruction of difference frequency supersonic melting are sent to the ultrasonic transmitting device 102 by 103；
When the second index variable quantity reaches the second pre-set level variable quantity, the central processor equipment 103
The positioning instruction for positioning next target spot and difference frequency ultrasound stimulation instruction are sent to the ultrasonic transmitting device 102.
It also needs to be illustrated, obtains the first index variation in multiple biological signal processors 101
During amount, the central processor equipment 103 to the ultrasonic transmitting device 102 send navigate to target spot instruction and
The instruction of difference frequency ultrasound stimulation is carried out, to the target spot so as to cause the variation of bio signal；Likewise, in multiple biologies
During signal handling equipment 101 obtains the second index variable quantity, the central processor equipment 103 is sent out to the ultrasonic wave
Jet device 102 sends difference frequency ultrasound stimulation instruction and carries out difference frequency ultrasound stimulation to the target spot after ablation to realize, so as to cause life
The variation of object signal.
A kind of ultrasonic medical system as disclosed in the embodiments of the present invention it can be concluded that, the embodiment of the present invention passes through biology
Signal handling equipment calculates the difference of bio signal of the target spot before and after difference frequency ultrasound stimulation, generates the first index variable quantity, with
And target spot carries out the bio signal after difference frequency ultrasound stimulation difference before difference frequency ultrasound stimulation and after ablation is calculated, generate second
Index variable quantity；Central processor equipment determines target according to the comparison result of the first index variable quantity and the first pre-set level variable quantity
Point whether reach degree in need for the treatment of, thus control ultrasonic transmitting device whether to target spot emit with frequency or difference frequency ultrasound into
Row ablation, and determine that target spot is after ablation according to the comparison result of the second index variable quantity and the second pre-set level variable quantity
It is no to melt successfully, to control whether ultrasonic transmitting device needs to melt target spot again.
It can be seen that this system can be realized diagnosis to the target spot of positioning and in the assessment to ablation effect, from
And realize the integration and automation of diagnosis and treatment process.
Embodiment two
Based on a kind of ultrasonic medical system that the embodiments of the present invention one provide, the present invention as shown in Fig. 2 is implemented
The structural schematic diagram for the biological signal processor in a kind of ultrasonic medical system that example two provides, at the bio signal
Manage equipment 101, comprising: multiple biological signal collecting devices 1011, and with multiple biological signal collecting devices 1,011 1
The one corresponding multiple bio signal processing units 1012 being connected；
The biological signal collecting device 1011, for acquiring first bio signal of the target spot before difference frequency ultrasound stimulation,
In the third biology of the second bio signal after the difference frequency ultrasound stimulation and the target spot after ablation after difference frequency ultrasound stimulation
Signal, and first bio signal, second bio signal and the third bio signal are sent to the biology and believed
Number processing unit 1012；
The bio signal processing unit 1012 generates for carrying out processing to first bio signal received
One index value carries out processing to second bio signal received and generates the second index value and to described the received
Three bio signals carry out processing and generate third index value, and calculate the difference of first index value and second index value,
The first index variable quantity is obtained, and calculates the difference of first index value and the third index value, obtains the second index
Variable quantity, and the first index variable quantity and the second index variable quantity are sent to the central processor equipment 103.
Preferably, when the biological signal collecting device 1011 includes: electrode slice, the bio signal processing unit
1012 include: electrocardiograph analyzer, respiration monitor and/or electroencephalograph；
When the biological signal collecting device 1011 includes: pressure transducer, the bio signal processing unit 1012
It include: physiograph；
When the biological signal collecting device 1011 includes: neuropotential probe, the bio signal processing unit
1012 include: neuropotential analyzer；
When the biological signal collecting device 1011 includes: blood biochemical signal probe, the bio signal processing dress
Setting 1012 includes: seralyzer.
It needs to be illustrated, the biological signal collecting device includes but is not limited to electrode slice, pressure transducer, mind
It also may include other for obtaining the device of bio signal, accordingly through potential probes and/or blood biochemical signal probe
, the bio signal processing unit includes but is not limited to electrocardiograph analyzer, respiration monitor, physiograph, neuropotential
Analyzer and/or blood biochemical signal probe can also include the device that other are used to handle bio signal accordingly.
A kind of ultrasonic medical system as disclosed in the embodiments of the present invention it can be concluded that, present embodiment discloses biology believe
Number processing equipment includes biological signal collecting device and bio signal processing unit, and biological signal collecting device acquires the target spot
The first bio signal before difference frequency ultrasound stimulation, in the second bio signal after the difference frequency ultrasound stimulation and after melting
Third bio signal of the target spot after difference frequency ultrasound stimulation；Bio signal processing unit is to first bio signal received
It carries out processing and generates the first index value, processing is carried out to second bio signal received and generates the second index value and right
The third bio signal received carries out processing and generates third index value, and calculates first index value and described second
The difference of index value obtains the first index variable quantity, and calculates first index value and the third index value
Difference obtains the second index variable quantity, so that central processor equipment is according to the first index variable quantity and the first pre-set level
The comparison result of variable quantity determines whether target spot reaches degree in need for the treatment of, to whether control ultrasonic transmitting device to target
The instruction of point transmitting ablation, and target spot is determined according to the comparison result of the second index variable quantity and the second pre-set level variable quantity
Whether success is melted after ablation, to control whether ultrasonic transmitting device needs to melt target spot again.
It can be seen that this system can the diagnosis to the target spot of positioning and the assessment to ablation effect, thus realize examine
The integration and automation for the treatment of process.
Embodiment three
Based on a kind of ultrasonic medical system that the embodiments of the present invention one provide, the present invention as shown in Fig. 3 is implemented
A kind of structural schematic diagram for the ultrasonic transmitting device in ultrasonic medical system that example three provides, the ultrasonic wave transmitting are set
Standby 102, comprising: ultrasonic imaging driving device 1021, ultrasonic driving apparatus 1022 and phased array joint probe 1023；
The ultrasonic imaging driving device 1021 is visited for controlling the phased array joint according to the imaging instruction received
First 1023 transmitting ultrasonic imaging signal, and the ultrasonic reflections signal received is sent to central processor equipment 103；
The ultrasonic driving apparatus 1022, target spot positioning instruction for will receive, difference frequency ultrasound stimulation instruction and
The phased array joint probe 1023 is sent to the instruction of frequency supersonic melting or the instruction of difference frequency supersonic melting；
The phased array joint probe 1023, for being sent out according to the imaging instruction to organism destination organization target area
Imaging ultrasound wave is penetrated, and the ultrasonic reflections signal of feedback is sent to the ultrasonic imaging driving device 1021 and base
It is moved to corresponding target spot to be positioned in the corresponding target spot positioning instruction, is instructed based on the difference frequency ultrasound stimulation to described
Target spot transmitting difference frequency ultrasound is stimulated, and is instructed based on the instruction of same frequency supersonic melting or difference frequency supersonic melting to the target spot
Transmitting is melted with frequency or difference frequency ultrasound.
Preferably, the ultrasound in a kind of ultrasonic medical system that the embodiment of the present invention three as shown in Fig. 4 provides
Another structural schematic diagram of wave transmitting device, wherein the ultrasonic imaging driving device 1021, comprising:
Ultrasonic imaging driving unit 10211, the imaging instruction sent for receiving the central processor equipment 103,
And the imaging instruction is sent to and states phased array joint probe 1023；
Signal processing unit 10212, for receiving 1023 pairs of organism destination organization target areas of the phased array joint probe
The ultrasonic reflections signal being scanned, and it is transmitted to the central processor equipment 103.
Preferably, the ultrasound in a kind of ultrasonic medical system that the embodiment of the present invention three as shown in Fig. 4 provides
Another structural schematic diagram of wave transmitting device, wherein the phased array joint probe 1023, comprising:
Phased array supersonic imaging probe 10231, for according to the ultrasonic imaging driving unit 10211 send it is described at
Emit the imaging ultrasound wave as instructing to organism destination organization target area and is scanned, and by the ultrasonic wave of feedback
Reflection signal is sent to the signal processing unit 10212；
Wherein, the arrangement mode of the phased array supersonic imaging probe 10231 include: linear array, two-dimensional rectangle array,
Circular array or spherical array；
It needs to be illustrated, the arrangement mode of the phased array supersonic imaging probe 10231 includes but is not limited to line
Property array, two-dimensional rectangle array, circular array or spherical array, also may include other arrangement modes.
Phase array transducer array 10232, it is fixed for receiving the target spot that the ultrasonic driving apparatus 1022 is sent
Bit instruction, difference frequency ultrasound stimulation instruct and with the instruction of frequency supersonic melting or the instructions of difference frequency supersonic melting, and are determined according to the target spot
Bit instruction is moved to corresponding target spot to be positioned, and it is super to emit the difference frequency to the target spot according to difference frequency ultrasound stimulation instruction
Sound is stimulated, and is emitted the target spot with frequency or difference frequency according to the same frequency supersonic melting instruction or the instruction of difference frequency supersonic melting
Ultrasound is melted；
Combine the composition knot of probe described in a kind of ultrasonic medical system that the offer of the embodiment of the present invention three is provided
Composition；
The phase array transducer array 10232 include it is multiple equal in magnitude, worked independently by autonomous channel 11
Ultrasonic transducer array element, the multiple ultrasonic transducer array element, for being moved according to the positioning instruction in target area, from
It is dynamic to find target spot, and when the target spot occurs mobile, for tracking, positioning the target spot；And for passing through the independence
Channel 11 emits ultrasonic wave to the target spot, carries out difference frequency ultrasound stimulation to the target spot or carries out the target spot with frequency ultrasound
Ablation or difference frequency supersonic melting；
And the arrangement mode of multiple ultrasonic transducer array elements include: linear array, annular array, Concentric circle array,
Rectangular array, fan-shaped array or on-demand irregular array.
Need to be illustrated, when the different ultrasonic transducer array element emitted by the autonomous channel 11 it is low strong
Degree, different frequency ultrasonic wave when, stimulate the target spot, and cause the variation of bio signal；When the different ultrasonic transductions
When device array element emits the ultrasonic wave of high-intensitive, identical or different frequency by the autonomous channel 11, corresponding biology is generated
Effect melts the target spot.
It also needs to be illustrated, the arrangement mode of multiple ultrasonic transducer array elements includes but is not limited to linear battle array
Column, annular array, Concentric circle array, rectangular array, fan-shaped array or on-demand irregular array can also include other arrangements
Mode.
A kind of ultrasonic medical system as disclosed in the embodiments of the present invention it can be concluded that, present embodiment discloses ultrasonic waves
Transmitting equipment includes ultrasonic imaging driving device, ultrasonic driving apparatus and phased array joint probe, and is disclosed accordingly
The concrete composition of concrete composition and phased array the joint probe of ultrasonic imaging driving device is realized super to target spot transmission difference frequency
When sound is stimulated, cause the change of the bio signal of organism, therefore, it is determined that whether target spot is melted, and to target spot
It sends and is melted with frequency or difference frequency ultrasound, and difference frequency ultrasound stimulation is carried out again to target spot after ablation, therefore, it is determined that target
Whether point melts success, realizes the diagnosis to the target spot of positioning and the assessment of ablation effect, to realize diagnosis and treatment one
Change and automates.
Example IV
Based on a kind of ultrasonic medical system that the embodiments of the present invention one provide, the present invention as shown in Fig. 6 is implemented
The structural schematic diagram of central processor equipment described in a kind of ultrasonic medical system that example four provides, the central processor equipment 103,
Include:
The imaging instruction is simultaneously sent to the ultrasound by central control unit 1031, imaging instruction for receiving input
Wave emits equipment 102, and receives the ultrasonic reflections signal that the ultrasonic transmitting device 102 is fed back, and generates image letter
Breath；The instruction of input and the first pre-set level variable quantity and the second index variable quantity of input are received, and is sent
To feed back control system 1032；
Feed back control system 1032, the first index variable quantity sent for receiving the biological signal processor 101
With the second index variable quantity, according to the first index variable quantity and the comparison of the first pre-set level variable quantity received
As a result, and the second index variable quantity and the second pre-set level variable quantity received comparison result respectively to institute
It states ultrasonic transmitting device 102 and sends corresponding described instruction, until completing the ablation of all target spots；
Wherein, described instruction includes target spot positioning instruction and difference frequency ultrasound stimulation instruction, is instructed with frequency supersonic melting or poor
The instruction of frequency supersonic melting.
It should be noted that the equipment that feed back control system is configured to have intelligence learning function, can in diagnosis and
Learnt in therapeutic process and improves automatic control function.
It should also be noted that, in the embodiment of the present invention according to the first index variable quantity and receive described first
The comparison result of pre-set level variable quantity and the second index variable quantity and second pre-set level received change
The comparison result of amount sends the process and the embodiment of the present invention one of corresponding described instruction to the ultrasonic transmitting device respectively
In detailed process be consistent, therefore, which is not described herein again.
Preferably, the central control unit 1031 is also used to send releasing to the feed back control system 1032 or stop
Order only, and substitute the feed back control system 1032 and execute corresponding work；
Correspondingly, the feed back control system 1032, for receiving the instruction of the releasing or stopping, and releases or stops
Execute corresponding work.
A kind of ultrasonic medical system as disclosed in the embodiments of the present invention it can be concluded that, present embodiment discloses centres
Reason equipment includes central control unit and feed back control system, and central control unit receives the imaging instruction of input and by institute
It states imaging instruction and is sent to the ultrasonic transmitting device, and the ultrasonic wave for receiving the ultrasonic transmitting device feedback is anti-
Signal is penetrated, image information is generated；Receive the described instruction and the first pre-set level variable quantity of input and described of input
Second index variable quantity, and it is sent to feed back control system；Feed back control system receives the first index variable quantity and second
Index variable quantity, according to the first index variable quantity and the comparison result of the first pre-set level variable quantity received,
And the comparison result of the second index variable quantity and the second pre-set level variable quantity received surpasses to described respectively
Acoustic wave emitting device sends corresponding described instruction.
It can be seen that the embodiment of the present invention realizes the diagnosis to positioning target spot and the assessment of ablation effect, thus real
Diagnosis and treatment integration and automation are showed.
Further, central control unit is also used to send the order for releasing or stopping to feed back control system, and substitutes
Feed back control system executes corresponding work；Feed back control system for receiving the instruction for releasing or stopping, and releases or stops
Corresponding work is executed, realizing can be with manual operation central control unit, instead of feedback control in preset diagnosis and treatment process
Device executes corresponding work, realizes the assessment to the positioning of target spot, diagnosis and ablation effect, to realize diagnosis and treatment one
Change.
Embodiment five
Based on a kind of ultrasonic medical system that the embodiments of the present invention one provide, in the embodiment of the present invention five,
The ultrasonic transmitting device 102 is also used to receive the biology that multiple biological signal processors 101 are sent
Signal, and according to the breath signal in the bio signal received organism respiratory pause emit ultrasonic wave or according to
The electrocardiosignal in bio signal received emits ultrasonic wave in biological systemic heart isovolumic relaxation period or isovolumic contraction period.
It needs to be illustrated, when the ablation for heart area, then according to electrocardiosignal in heart isovolumetric relaxation
Phase or isovolumic contraction period carry out the transmitting of ultrasonic wave, to eliminate or reduce the influence of heart movement pair；When for non-cardiac region
Ablation when, then according to breath signal organism respiratory pause emit ultrasonic wave, with eliminate or reduce organism breathing when
Influence of the movement to ablation.
A kind of ultrasonic medical system as disclosed in the embodiments of the present invention it can be concluded that, the present embodiment pass through ultrasonic wave send out
Jet device receives the bio signal that multiple biological signal processors are sent, and is believed according to the breathing in the bio signal received
Number organism respiratory pause emit ultrasonic wave or according to the electrocardiosignal in the bio signal received in biological systemic heart
Isovolumic relaxation period or isovolumic contraction period emit ultrasonic wave, ensure that the accuracy to target spot transmitting difference frequency ultrasound or same frequency ultrasound,
Further ensure the effect for the treatment of and the safety of therapeutic process.
Embodiment six
The embodiment of the present invention six provides a kind of ultrasonic medical method, disclosed in the embodiment of the present invention six as shown in attached drawing 7
A kind of flow chart of ultrasonic medical method, which comprises
S1: positioning multiple target spots in biological targets tissue target area based on image information and positioning instruction, determines
The target spot of positioning；
S2: the difference of bio signal of the target spot for acquiring the positioning before and after difference frequency ultrasound stimulation is calculated, generates first
Index variable quantity；
S3: judging whether the first index variable quantity reaches the first pre-set level variable quantity, if so, executing step
S4 returns to step S2 if not, navigating to next target spot；
S4: the target spot is emitted and is melted with frequency or difference frequency ultrasound；
S5: it calculates the target spot of acquisition and carries out difference frequency ultrasound stimulation before difference frequency ultrasound stimulation and after target spot ablation
The difference of bio signal afterwards generates the second index variable quantity；
S6: judging whether the second index variable quantity reaches the second pre-set level variable quantity, if so, navigating to next
Target spot executes step S2, if not, executing step S4；Until completing the ablation of all target spots.
Preferably, after judging whether the first index variable quantity reaches the first pre-set level variable quantity, further includes:
If it is, recording to the target spot of the positioning, and next target spot is navigated to, executes step S2；If it is not, then navigating to
Next target spot executes step S2, until recording target spot in need for the treatment of in all investigative ranges；
It is finding in investigative range after target spot in need for the treatment of, to the target spot transmitting in need for the treatment of with frequency or difference frequency
Ultrasound is melted, and is calculated the target spot in need for the treatment of and carried out difference frequency ultrasound stimulation before difference frequency ultrasound stimulation and after ablation
The difference of bio signal afterwards generates the second index variable quantity, and it is pre- to judge whether the second index variable quantity reaches second
If index variable quantity, if it is, determining to melt successfully；If it is not, then being melted again, until completing to control the needs
The ablation of the target spot for the treatment of.
A kind of ultrasonic medical method as disclosed in the embodiments of the present invention it can be concluded that, the present embodiment passes through according to first
The comparison result of index variable quantity and the first pre-set level variable quantity determines whether target spot reaches degree in need for the treatment of, to control
The instruction whether ultrasonic transmitting device processed melts target spot transmitting, and according to the second index variable quantity and the second pre-set level
Whether the comparison result of variable quantity determines whether target spot melts success after ablation, need pair to control ultrasonic transmitting device
Target spot is melted again.
It can be seen that this method can be realized to the diagnosis of positioning target spot and after ablation to the assessment of ablation effect,
To realize the integration and automation of diagnosis and treatment process.
Further, after finding the target spot for meeting the first pre-set level variable quantity, which is recorded, is continued pair
Surrounding tissue is detected, until recording the target spot in all investigative ranges, then is melted, and determines whether ablation succeeds.
Likewise, this method can be realized to the diagnosis of positioning target spot and after ablation to the assessment of ablation effect, examined to realize
The integration and automation for the treatment of process.
Based on a kind of ultrasonic medical system and method disclosed in the embodiments of the present invention, by following application example into
Row further illustrates:
Application example one
This application example first is that the embodiments of the present invention provide a kind of ultrasonic medical system and method in renal sympathetic mind
Through the application in ablation.
It is illustrated in figure 8 the schematic diagram for the renal sympathetic nerve target spot plan that application example one of the present invention provides.In described
Under the guidance for entreating the image information of processing unit 103, select the arteria renalis 201 and its surrounding tissue for target area, in the arteria renalis
On long axis direction, many levels 202 are selected from the arteria renalis proximal end to distal end by equidistant intervals, in multiple levels
On 202, centered on 201 cross section of the arteria renalis, the target that selects surrounding multiple regions as target spot 203, and will make
Point plan is input to the central processor equipment 103.
Phased array joint probe 1023 in the ultrasonic transmitting device 102 navigates to target according to the target spot plan of input
After point, the ultrasonic wave driving unit 1022 in the ultrasonic transmitting device 102 passes through 11 control unit of autonomous channel
Dividing ultrasonic transducer array element tranmitting frequency is f1Low-intensity ultrasonic, pass through the autonomous channel 11 control another part ultrasound
Transducer array element tranmitting frequency is f2Low-intensity ultrasonic, the ultrasonic wave of two kinds of different frequencies produces at the target spot of positioning
Raw difference frequency interference effect, generation frequency are f3=| f1-f2| low-frequency sound wave, the target spot is stimulated.
Before and after the ultrasonic transmitting device 102 carries out difference frequency ultrasound stimulation to the target spot 203 of positioning, the bio signal
Processing equipment 101 acquires the blood pressure of human body, heart rate, heart rate variability, breathing, neuropotential, electroencephalogram, myoelectrical activity described
Variable quantity before and after difference frequency ultrasound stimulation, and the first index variable quantity is generated, and the first index variable quantity is sent to institute
Central processor equipment 103 is stated, is deposited in advance in central processor equipment 103 if the first index variable quantity of target spot 203 does not reach
First pre-set level variable quantity of storage, then the central processor equipment 103 controls the ultrasonic transmitting device 102 and navigates to down
One target spot, and difference frequency ultrasound stimulation is carried out to next target spot；If it is default that the first index variable quantity has reached described first
Index variable quantity then determines renal sympathetic nerve excessive activation, selectes the target spot 203 as ablation targets, at this point, central processing is set
Standby 103 control ultrasonic transmitting device 102 emits with frequency or difference frequency ablation ultrasonic wave, melts to the target spot 203.
After ablation, central processor equipment 103 controls the ultrasonic transmitting device 102 and switches to difference frequency ultrasound stimulation mould
Formula carries out difference frequency ultrasound stimulation to the target spot 203 after ablation again, at this point, the biological signal processor 101 calculate it is described
The bio signal and bio signal after difference frequency ultrasound stimulation after ablation that target spot 203 does not carry out difference frequency ultrasound stimulation before ablation
Variable quantity generates the second index variable quantity.If the second index variable quantity reaches in the central processor equipment 103 in advance
Second pre-set level variable quantity of storage, then it is assumed that renal sympathetic nerve has been destroyed, and the target spot 203 melts successfully, at this point,
Central processor equipment 103 controls the ultrasonic transmitting device 102 and navigates to next target spot；If the second index variable quantity
The not up to described second pre-set level variable quantity then determines that ablation is failed, and the central processor equipment 103 controls the ultrasound
Wave transmitting equipment 102 melts the target spot 203 again, until complete the target spot in the works the diagnosis of all target spots and
Ablation.
In positioning, diagnosis and ablation procedure, the ultrasonic transmitting device 102 is all to carry out in respiratory pause to target spot
Ultrasonic wave transmitting.It is instructed in addition, operator can be inputted by the central control unit 1031 in central processor equipment 103,
The feed back control system 1032 for releasing or stopping in the central processor equipment 103 works accordingly, and manual operation
Central control unit 1031 is worked accordingly.
Application example two
This application example is second is that a kind of ultrasonic medical system and method that the embodiments of the present invention provide swells in secretory
Application in the diagnosing and treating of tumor.
It is illustrated in figure 9 the schematic diagram for the secretory tumor targets plan that application example two of the present invention provides.In described
Under the guidance for entreating the image information of processing unit 103, selects tumour 211 and its surrounding tissue for target area, selected with equidistant intervals
The section 212 is divided into more by the multiple sections 212 for selecting target area on multiple sections 212 with certain interval in length and breadth
A block is input in the central processor equipment 103 as target spot 213, and by the target spot plan made.
Phased array joint probe 1023 in the ultrasonic transmitting device 102 navigates to target according to the target spot plan of input
After point 213, the ultrasonic wave driving unit 1022 in the ultrasonic transmitting device 102 is controlled by the autonomous channel 11
Part ultrasonic transducer array element tranmitting frequency is f1Low-intensity ultrasonic, it is super that another part is controlled by the autonomous channel 11
Sonic transducer array element tranmitting frequency is the low-intensity ultrasonic of f2, and the ultrasonic wave of two kinds of different frequencies is at the target spot of positioning
Difference frequency interference effect is generated, generation frequency is f3=| f1-f2| low-frequency sound wave, the target spot is stimulated.
Before and after the ultrasonic transmitting device 102 carries out difference frequency ultrasound stimulation to the target spot 213 of positioning, the bio signal
The bio signals such as blood pressure, heart rate and the blood plasma catechlolamine hormonal readiness of the acquisition of processing equipment 101 and analysis human body are in the difference
Variable quantity before and after frequency ultrasound stimulation, and generate the first index variable quantity, and the first index variable quantity is sent to described
Central processor equipment 103 is stored in advance in central processor equipment 103 if the first index variable quantity of target spot 213 does not reach
The first pre-set level variable quantity, then the central processor equipment 103 control the ultrasonic transmitting device 102 navigate to it is next
Target spot, and difference frequency ultrasound stimulation is carried out to next target spot；If the first index variable quantity has reached the described first default finger
Variable quantity is marked, then determines the target spot abnormal secretion, selectes the target spot 213 as ablation targets, at this point, central processor equipment 103
Control ultrasonic transmitting device 102 emits with frequency or difference frequency ablation ultrasonic wave, melts to the target spot 213.
After ablation, central processor equipment 103 controls the ultrasonic transmitting device 102 and switches to difference frequency ultrasound stimulation mould
Formula carries out difference frequency ultrasound stimulation to the target spot 213 after ablation again, at this point, the biological signal processor 101 calculate it is described
The bio signal and bio signal after difference frequency ultrasound stimulation after ablation that target spot 213 does not carry out difference frequency ultrasound stimulation before ablation
Variable quantity generates the second index variable quantity.If the second index variable quantity reaches in the central processor equipment 103 in advance
Second pre-set level variable quantity of storage, then determine that the target spot 213 melts successfully, at this point, central processor equipment 103 controls institute
It states ultrasonic transmitting device 102 and navigates to next target spot；If the second index variable quantity is not up to the described second default finger
Variable quantity is marked, then determines that ablation is failed, the central processor equipment 103 controls the ultrasonic transmitting device 102 to described
Target spot 213 is melted again, until completing the diagnosis and ablation of the target spot all target spots in the works.
In positioning, diagnosis and ablation procedure, the ultrasonic transmitting device 102 is all to carry out in respiratory pause to target spot
Ultrasonic wave transmitting.It is instructed in addition, operator can be inputted by the central control unit 1031 in central processor equipment 103,
The feed back control system 1032 for releasing or stopping in the central processor equipment 103 works accordingly, and manual operation
Central control unit 1031 is worked accordingly.
In addition, the ultrasonic medical system and method are also applied to including but not limited to arrhythmia cordis, nerve block
In the diagnosing and treatings of medical conditions such as analgesia.
It should be noted that all the embodiments in this specification are described in a progressive manner, each embodiment weight
Point explanation is the difference from other embodiments, and the same or similar parts between the embodiments can be referred to each other.
It should also be noted that, herein, relational terms such as first and second and the like are used merely to one
Entity or operation are distinguished with another entity or operation, without necessarily requiring or implying between these entities or operation
There are any actual relationship or orders.Moreover, the terms "include", "comprise" or its any other variant are intended to contain
Lid non-exclusive inclusion, so that the element that the process, method, article or equipment including a series of elements is intrinsic,
It further include either the element intrinsic for these process, method, article or equipments.
The foregoing description of the disclosed embodiments enables those skilled in the art to implement or use the present invention.
Various modifications to these embodiments will be readily apparent to those skilled in the art, as defined herein
General Principle can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, of the invention
It is not intended to be limited to the embodiments shown herein, and is to fit to and the principles and novel features disclosed herein phase one
The widest scope of cause.
Claims (9)
1. a kind of ultrasonic medical system, which is characterized in that the system, comprising: multiple biological signal processors, ultrasonic wave hair
Jet device and central processor equipment；
Multiple biological signal processors, the target spot that the ultrasonic transmitting device for calculating acquisition positions is in difference frequency
The difference of bio signal before and after ultrasound stimulation generates the first index variable quantity；And it calculates the target spot acquired and surpasses in difference frequency
The difference that the bio signal after difference frequency ultrasound stimulation is carried out before Sound stimulat and after ablation, generates the second index variable quantity, and by institute
It states the first index variable quantity and the second index variable quantity is sent to the central processor equipment；
The ultrasonic transmitting device, for super to the transmitting imaging of organism destination organization target area according to the imaging instruction received
Sound wave, and the ultrasonic reflections signal of feedback is sent to the central processor equipment；And it is sent out based on the central processor equipment
The corresponding instruction execution corresponding operation sent；
The imaging instruction is simultaneously sent to the ultrasound by the central processor equipment, the imaging instruction for receiving input
Wave emits equipment, and receives the ultrasonic reflections signal of the ultrasonic transmitting device feedback, generates image information；According to
The comparison of first pre-set level variable quantity of the first index variable quantity and input that the biological signal processor is sent
As a result, and the biological signal processor send the second index variable quantity and input the second pre-set level variation
The comparison result of amount sends corresponding instruction to the ultrasonic transmitting device respectively, until the ablation of all target spots is completed,
In, described instruction includes target spot positioning instruction and difference frequency ultrasound stimulation instruction, with the instruction of frequency supersonic melting or difference frequency supersonic melting
Instruction.
2. system according to claim 1, which is characterized in that the biological signal processor, comprising: multiple biology letters
Number acquisition device, and correspond the multiple bio signals processing being connected with multiple biological signal collecting devices and fill
It sets；
The biological signal collecting device, for acquiring first bio signal of the target spot before difference frequency ultrasound stimulation, in the difference
Third bio signal of the target spot after the second bio signal and ablation after difference frequency ultrasound stimulation after frequency ultrasound stimulation, and will
First bio signal, second bio signal and the third bio signal are sent to the bio signal processing dress
It sets；
The bio signal processing unit generates the first index for carrying out processing to first bio signal received
Value carries out processing to second bio signal received and generates the second index value and to the third biology received
Signal carries out processing and generates third index value, and calculates the difference of first index value and second index value, obtains the
One index variable quantity, and the difference of first index value and the third index value is calculated, the second index variable quantity is obtained,
And the first index variable quantity and the second index variable quantity are sent to central processor equipment.
3. system according to claim 2, which is characterized in that when the biological signal collecting device includes: electrode slice,
The bio signal processing unit includes: electrocardiograph analyzer, respiration monitor and/or electroencephalograph；
When the biological signal collecting device includes: pressure transducer, the bio signal processing unit includes: physiology record
Instrument；
When the biological signal collecting device includes: neuropotential probe, the bio signal processing unit includes: neuroelectricity
Position analyzer；
When the biological signal collecting device includes: blood biochemical signal probe, the bio signal processing unit includes: blood
Liquid Biochemical Analyzer.
4. system according to claim 1, which is characterized in that the ultrasonic transmitting device, comprising: ultrasonic imaging driving
Device, ultrasonic driving apparatus and phased array joint probe；
The ultrasonic imaging driving device, for according to the imaging instruction that receives control the phased array joint probe transmitting at
As ultrasonic wave, and the ultrasonic reflections signal received is sent to central processor equipment；
The ultrasonic driving apparatus, target spot positioning instruction and difference frequency ultrasound stimulation instruction for will receive, with frequency ultrasound
Ablation instruction or the instruction of difference frequency supersonic melting are sent to the phased array joint probe；
The phased array joint probe, for emitting imaging ultrasound to organism destination organization target area according to the imaging instruction
Wave, and the ultrasonic reflections signal of feedback is sent to the ultrasonic imaging driving device, and based on the corresponding target
Point location instruction is moved to corresponding target spot to be positioned, is instructed based on the difference frequency ultrasound stimulation super to target spot transmitting difference frequency
Sound is stimulated, and is instructed based on the instruction of same frequency supersonic melting or difference frequency supersonic melting to the target spot and emitted with frequency or difference frequency
Ultrasound is melted.
5. system according to claim 4, which is characterized in that the ultrasonic imaging driving device includes:
Ultrasonic imaging driving unit for receiving the imaging instruction of central processor equipment transmission, and the imaging instruction is sent
Combine to phased array and pops one's head in；
Signal processing unit, the ultrasound that organism destination organization target area is scanned for receiving the phased array joint probe
Wave reflection signal, and it is transmitted to the central processor equipment.
6. system according to claim 5, which is characterized in that the phased array joint, which is popped one's head in, includes:
Phased array supersonic imaging probe, the imaging instruction for being sent according to the ultrasonic imaging driving unit is to the life
Object target tissue target area emits the imaging ultrasound wave and is scanned, and the ultrasonic reflections signal of feedback is sent to
The signal processing unit；
Wherein, the arrangement mode of the phased array supersonic imaging probe includes: linear array, two-dimensional rectangle array, circular array
Or spherical array；
Phase array transducer array is super for receiving target spot positioning instruction, difference frequency that the ultrasonic driving apparatus is sent
Sound stimulat instructs and with the instruction of frequency supersonic melting or the instruction of difference frequency supersonic melting, and is moved to phase according to the target spot positioning instruction
Target spot to be positioned is answered, emitting the difference frequency ultrasound to the target spot according to difference frequency ultrasound stimulation instruction stimulates, root
The target spot is emitted according to the same frequency supersonic melting instruction or difference frequency supersonic melting instruction and is carried out with frequency or difference frequency ultrasound
Ablation；
Wherein, the phase array transducer array includes multiple equal in magnitude, the ultrasound to be worked independently by autonomous channel
Transducer array element, multiple ultrasonic transducer array elements, for being moved according to the positioning instruction in target area, Automatic-searching target
Point, and when the target spot occurs mobile, for tracking, position the target spot, and for by the autonomous channel to institute
Target spot transmitting ultrasonic wave is stated, difference frequency ultrasound stimulation is carried out to the target spot or the target spot is carried out with frequency supersonic melting or difference
Frequency supersonic melting；
And the arrangement mode of multiple ultrasonic transducer array elements includes: linear array, annular array, Concentric circle array, rectangle
Array, fan-shaped array or on-demand irregular array.
7. system according to claim 1, which is characterized in that the central processor equipment, comprising:
The imaging instruction is simultaneously sent to ultrasonic wave transmitting and set by central control unit, imaging instruction for receiving input
It is standby, and the ultrasonic reflections signal of the ultrasonic transmitting device feedback is received, generate image information；Receive input instruction with
And the first pre-set level variable quantity and the second index variable quantity of input, and it is sent to feed back control system；
Feed back control system, for receiving the first index variable quantity and the change of the second index that the biological signal processor is sent
Change amount, according to the first index variable quantity and the comparison result of the first pre-set level variable quantity received and described the
The comparison result of two index variable quantities and the second pre-set level variable quantity received is sent out to the ultrasonic transmitting device respectively
Corresponding instruction is sent, until completing the ablation of all target spots；
Wherein, described instruction includes target spot positioning instruction and difference frequency ultrasound stimulation instruction, is surpassed with the instruction of frequency supersonic melting or difference frequency
Sound ablation instruction.
8. system according to claim 7, which is characterized in that the central control unit is also used to control to the feedback
Device processed sends the order for releasing or stopping, and substitutes the feed back control system and execute corresponding work；
Correspondingly, the feed back control system, for receiving the instruction of the releasing or stopping, and releases or stops executing corresponding
Work.
9. system according to claim 1, which is characterized in that the ultrasonic transmitting device is also used to receive multiple institutes
The bio signal of biological signal processor transmission is stated, and according to the breath signal in the bio signal received in biology
The respiratory pause of body emits ultrasonic wave or according to the electrocardiosignal in the bio signal received in biological systemic heart isovolumetric relaxation
Phase or isovolumic contraction period emit ultrasonic wave.
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| CN107362466B (en) * | 2017-06-29 | 2019-12-10 | 哈尔滨医科大学 | Ultrasonic focusing method for acoustic dynamic therapy |
| FR3081334B1 (en) * | 2018-05-25 | 2020-05-01 | Cardiawave Sa | ULTRASONIC TREATMENT APPARATUS COMPRISING MEANS OF IMAGING CAVITATION BUBBLES |
| CN108924353A (en) * | 2018-06-29 | 2018-11-30 | 努比亚技术有限公司 | anti-interference method, mobile terminal and computer readable storage medium |
| CN110236590A (en) * | 2019-06-21 | 2019-09-17 | 南方医科大学 | A kind of portable orthopaedics ultrasonic medical instrument based on wireless telecommunications |
| CN110465008B (en) * | 2019-08-28 | 2021-02-12 | 黄晶 | Focused ultrasound treatment system |
| CN110559564B (en) * | 2019-09-02 | 2021-08-20 | 深圳先进技术研究院 | Ultrasonic stimulation device, terminal and medium |
| CN110575628B (en) * | 2019-09-24 | 2021-09-07 | 黄晶 | Detection and ablation integrated double-mark measuring system |
| CN110743107A (en) * | 2019-10-25 | 2020-02-04 | 南京大学 | STM32F 334-based high-power high-intensity focused ultrasound driving system |
| WO2021097674A1 (en) * | 2019-11-19 | 2021-05-27 | 深圳先进技术研究院 | Blood brain barrier permeability regulation and control device and method, and storage medium |
| CN117398122A (en) * | 2023-09-07 | 2024-01-16 | 深圳高性能医疗器械国家研究院有限公司 | Ultrasonic diagnosis and treatment equipment and control method |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101065066A (en) * | 2004-11-30 | 2007-10-31 | 全音速医学技术有限公司 | Ultrasonic medical equipment with variable frequency drive |
| CN102793980A (en) * | 2011-05-24 | 2012-11-28 | 重庆融海超声医学工程研究中心有限公司 | Double-frequency focused ultrasound system |
| CN104622504A (en) * | 2015-02-12 | 2015-05-20 | 黄晶 | Phased array high-intensity focused ultrasonic detection and therapy system |
| WO2016058963A1 (en) * | 2014-10-17 | 2016-04-21 | Koninklijke Philips N.V. | An ultrasound patch for ultrasound hyperthermia and imaging |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060079868A1 (en) * | 2004-10-07 | 2006-04-13 | Guided Therapy Systems, L.L.C. | Method and system for treatment of blood vessel disorders |
-
2016
- 2016-05-24 CN CN201610349799.4A patent/CN106063712B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101065066A (en) * | 2004-11-30 | 2007-10-31 | 全音速医学技术有限公司 | Ultrasonic medical equipment with variable frequency drive |
| CN102793980A (en) * | 2011-05-24 | 2012-11-28 | 重庆融海超声医学工程研究中心有限公司 | Double-frequency focused ultrasound system |
| WO2016058963A1 (en) * | 2014-10-17 | 2016-04-21 | Koninklijke Philips N.V. | An ultrasound patch for ultrasound hyperthermia and imaging |
| CN104622504A (en) * | 2015-02-12 | 2015-05-20 | 黄晶 | Phased array high-intensity focused ultrasonic detection and therapy system |
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|---|---|
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