CN105427727A - Method for manufacturing soft tissue pathological model by means of new material 3D printing - Google Patents
Method for manufacturing soft tissue pathological model by means of new material 3D printing Download PDFInfo
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Abstract
The invention discloses a method for manufacturing a soft tissue pathological model by means of new material 3D printing. The method comprises the steps of 1) acquiring true condition of a diseased portion of a patient through imaging equipment, thereby obtaining data of which storage format is DICOM; 2) reconstructing a model by means of professional software according to the acquired data on a graphical work station; and 3) by means of a red silica gel, a green silica gel and a blue silica gel which are different from a traditional 3D printing material as raw materials, printing the pathological model which is same with an in-vivo true condition by a silica gel 3D printer. According to the soft tissue pathological model manufactured according to the method of the invention, the aspects such as accuracy, internal-and-external structure, surrounding tissue association, texture, handfeel and color approach the in-vivo condition of the patient. The soft tissue pathological model manufactured according to the method of the invention has the following advantages over a traditional pathological model at aspects such as medical science, veterinary medicine and science exhibition: higher accuracy, higher fidelity and more attractive appearance.
Description
Technical field
The present invention relates to a kind of method for making of soft tissue pathological model, specifically a kind of method for making utilizing new material 3D to print soft tissue pathological model, belongs to medical pathologies modelling technique field.
Background technology
Along with the development of the subjects such as medical science, public hygienics, veterinary science, teaching, science popularization displaying etc. are also increasing to the demand of medical model.Start most traditional medicine model manufacturing technique simple and crude coarse, degree of accuracy and authenticity poor, not easily transport preservation, and generally only visually can give and show intuitively.The realistic model degree of accuracy of selling in the market is greatly improved, some privileged sites as the texture such as bone, tooth also with organize really similar, but this kind of low side realistic model is owing to being subject to the impact of producing material, only can be applied to comparatively sclerous tissues.Also have some simulated humanbody living models, although joint is movable, skin emolliency, is also only applied to the making of body surface or shallow layer tissue's model.
It is all generally produce according to standard is unified that normal medical science correlation model makes, can only represent body normal time situation, have certain effect for medical teaching, science popularization displaying etc.And when disease occurs, due to the not equal reason of individual difference, kinds of Diseases, the state of an illness, the pathological condition that everyone often plants disease has difference, at this moment truly specifically can show the inner and external pathological change of morbidity organ, the formulation for the Diagnosis and Treat scheme of doctor just seems particularly important.When the medic of just graduation performs the operation in addition, or when some state of an illness complexity, non-common disease are performed the operation, owing to lacking experience, carrying out certain class operation first can be lowered into power.
Current general medical science model is mainly for normal tissue and make according to unified standard, has the related data of each normal structure organ to do reference, just can complete as long as carry out making according to standard, and that understands normal structure for people is configured with larger help.But pathological tissue belongs to abnormal condition, the change such as its size, profile, inner structure is irregular, therefore, the model of common process manufacture is difficult to embody actual pathological change really on the one hand, and these pathological models made are also mainly for the typical pathologic change occurred on the other hand.Tradition pathological model makes according to generally deriving from anatomic tissue or sample, can only with the pathological change of histoorgan during body death for foundation, at this moment because body physiological function stops, the pathological model made on this basis may with some deviation of truth.Traditional medicine pathological model is except the effect of grade is shown in teaching in addition, does not substantially have other purposes.
Summary of the invention
Have problems for above-mentioned prior art, the invention provides a kind of method for making utilizing new material 3D to print soft tissue pathological model, the pathological model produced by the method can embody the actual state of body tissue organ more truely and accurately, and by the utilization of color, can take pathological change as foundation, more show the pathological change of histoorgan concrete facticity.
The present invention is achieved through the following technical solutions above-mentioned purpose: a kind of method for making utilizing new material 3D to print soft tissue pathological model, the method comprises the steps:
1), collected the truth of patient diseased region by iconography equipment, obtaining preserving form is the data of DICOM;
2), according to the data collected on graphics workstation, professional software reconstruction model is used;
3), the silica gel that utilizes red, green, blue three kind colors different from traditional 3D printed material is raw material, and the printing of silica gel 3D printer is for the consistent pathological model of truth in body.
Further, described iconography equipment is CT or NMR.
Further, described step 3) in, the operating process of silica gel 3D printer is as follows:
1), utilize special 3D printer nozzle, small silicone fluid is dripped in the plane, and print according to pathology actual conditions;
2), what print is an imperceptible silica gel line, silica gel drop economy-combat print machine nozzle spray shaping while adopt ultraviolet light carry out photocuring to the silica gel drop be up to and print next line,
3), constantly step 2 is repeated) form tangent plane, continue again after one deck tangent plane completes to print lower one deck, complete completely until model prints.
The invention has the beneficial effects as follows: the pathological model 1), by the method produced on the displays such as medical science, veterinary science, science popularization, than traditional pathological model more accurately, more true to nature, more attractive in appearance, more easily transport preservation than Pathologic specimen.
2) the pathological model teaching aid, by the method produced is applied to teaching purposes, the pathological model quality made due to us and body tissue similar, can be used for student to practise the operations such as operation, stitching on our model.
3), in hospital diagnosis treatment field, the model manufactured by the method can according to doctor's needs, according to the image data that hospital's checkout equipment provides, produce the model consistent with pathological change in patient body, intuitively for doctor provides the truth of patient's state of an illness, larger help can be had for medical diagnosis on disease and treatment.
4), the model that manufactures of the method is in degree of accuracy, internal structure external structure, all close with situation in patient body with in the associating of perienchyma, quality, feel, even color etc. are individual.The operation of some new appearance, special, non-common disease or state of an illness more complicated, lack and even there is no former operation plan, directly very likely cause operative failure in patient operation, first can operate on our model before operation is implemented in such situation, formulate by exercise and improve operation method, improving the success ratio of operation.
Accompanying drawing explanation
Fig. 1 is that 3D of the present invention prints overall flow schematic diagram;
Fig. 2 is diseased region information schematic diagram of the present invention;
Fig. 3 is one of embodiment of the present invention schematic diagram;
Fig. 4 is embodiment of the present invention schematic diagram two;
Fig. 5 is embodiment of the present invention schematic diagram three;
Fig. 6 is embodiment of the present invention schematic diagram four.
Embodiment
Below in conjunction with the accompanying drawing in the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
As depicted in figs. 1 and 2: a kind of method for making utilizing new material 3D to print soft tissue pathological model, the method comprises the steps:
1), collected the truth of patient diseased region by iconography equipment, obtaining preserving form is the data of DICOM;
2), according to the data collected on graphics workstation, professional software reconstruction model is used;
3), the silica gel that utilizes red, green, blue three kind colors different from traditional 3D printed material is raw material, and the printing of silica gel 3D printer is for the consistent pathological model of truth in body.
Further, described iconography equipment is CT or NMR.
Further, described step 3) in, the operating process of silica gel 3D printer is as follows:
1), utilize special nozzle, small silicon sol is dripped in the plane, and print according to pathology actual conditions;
2), what print is an imperceptible silica gel line, silica gel drop economy-combat print machine nozzle spray shaping while adopt ultraviolet light carry out photocuring to the silica gel drop be up to and print next line;
3), constantly step 2 is repeated) form tangent plane, continue again after one deck tangent plane completes to print lower one deck, complete completely until model prints.
The iconography such as CT, NMR detects, and can show different patient's pathological tissue situation truly in detail.The making that new material 3D prints soft tissue pathological model collects related pathologies data based on technology such as CT, NMR, then with the perfect adaptation of 3D printing technique, and utilize high emulation biomaterial to print, owing to selecting special printed material not only can truly intuitively for doctor reflects the real conditions of histopathology, and the aspect such as its structure (comprising interior detail microstructure), quality, color, feel is also close with live tissue organ, even can be used for doctor to perform the operation in advance at formal operation consent.In addition owing to selecting colored raw material, we also can carry out special painted according to demand to the diseased region in model, reach the effect of some emphasis outstanding.
It is expensive that conventional model makes die sinking expense, a small amount of production cost is high, the pathological model that the situation that is not suitable for is changeable makes, and manufacture craft is coarse simple and crude, the finishing applications made is few, not easily preserve, our Novel pathological model can save huge die sinking expense, can be patient's personalized customization model.New material 3D prints soft tissue pathological model, can be as required, to health tissues organ in body or any period at disease progression, with the pathological change of patient's body for foundation, produce and organism physiology, the pathology model that (comprising histoorgan inner structure), truth was consistent, so not only pathologic condition intuitively can be provided to show for doctor, to the diagnosis of doctor, the formulation for the treatment of or operation plan has great help, and because our manufactured materials is in quality, feel, the each side such as color are all similar to body tissue, therefore, treatment doctor even can perform the operation in advance on our model, pre-operation improves the success ratio of operation, this point is for complexity, the doctor that the operation of non-common disease and some experiences are short of a little seems even more important.
According to three primary color theory, any color all can mix in different ratios by these 3 kinds of colors of red, green, blue, the red green blue tricolor color silica gel that the raw material choose of our printer model is different from the past traditional 3D printed material, this raw material and tissue similarity high, after making model, validity is high, the each side such as quality, feel also with organize really similar, this material viscosity is high, have photosensitivity, after UV-irradiation, silica gel is cured very soon and is cross-linked to form soft solid material.
Embodiment one
For the case mode of heart for building,
1), the imaging data at abundant heart of patient position is first successively collected with CT equipment, as Fig. 3 and Fig. 4.
2), utilize related software to carry out structure process to the data collected, remove unwanted tissue site, as Fig. 5.
3), processed after, according to software building pathological model out, with color silica gel material for raw material, printed the case mode of needs by 3D printer, as Fig. 6.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment made, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (3)
1. utilize new material 3D to print a method for making for soft tissue pathological model, it is characterized in that, the method comprises the steps:
1), collected the truth of patient diseased region by iconography equipment, obtaining preserving form is the data of DICOM;
2), according to the data collected on graphics workstation, professional software reconstruction model is used;
3), the silica gel that utilizes red, green, blue three kind colors different from traditional 3D printed material is raw material, and the printing of silica gel 3D printer is for the consistent pathological model of truth in body.
2. a kind of method for making utilizing new material 3D to print soft tissue pathological model according to claim 1, it is characterized in that, described iconography equipment is CT or NMR.
3. a kind of method for making utilizing new material 3D to print soft tissue pathological model according to claim 1 and 2, is characterized in that, described step 3) in, the operating process of silica gel 3D printer is as follows:
1), utilize special 3D printer nozzle, small silicone fluid is dripped in the plane, and print according to pathology actual conditions;
2), what print is an imperceptible silica gel line, silica gel drop economy-combat print machine nozzle spray shaping while adopt ultraviolet light carry out photocuring to the silica gel drop be up to and print next line.
3), constantly step 2 is repeated) form tangent plane, continue again after one deck tangent plane completes to print lower one deck, complete completely until model prints.
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Cited By (6)
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| CN106652709A (en) * | 2016-11-24 | 2017-05-10 | 王知非 | Anastomosis surgery model used by matching with da Vinci surgical robot and manufacturing method of anastomosis surgery model |
| CN106781956A (en) * | 2016-12-14 | 2017-05-31 | 三的部落（上海）科技股份有限公司 | The method that reusable medical operation training pattern is obtained using 3D printing |
| CN107049486A (en) * | 2017-03-29 | 2017-08-18 | 广州博敏科技有限公司 | Aneurysm vascular model and its preparation method and application |
| CN108354651A (en) * | 2018-01-09 | 2018-08-03 | 浙江省肿瘤医院 | It is prepared using digitlization Space Reconstruction and 3D printing for determining that soft tissue surfaces substitute the method for cutting guide plate of flap size |
| CN108670362A (en) * | 2018-01-09 | 2018-10-19 | 浙江省肿瘤医院 | The method for cutting guide plate and determining cut soft tissue replacement flap volume is prepared using digitlization Space Reconstruction and 3D printing technique |
| CN109014251A (en) * | 2018-09-25 | 2018-12-18 | 天津职业技术师范大学 | A kind of CA6140 Lathe Spindle Box teaching aid based on 3D printing |
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|---|---|---|---|---|
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| CN108670362A (en) * | 2018-01-09 | 2018-10-19 | 浙江省肿瘤医院 | The method for cutting guide plate and determining cut soft tissue replacement flap volume is prepared using digitlization Space Reconstruction and 3D printing technique |
| CN109014251A (en) * | 2018-09-25 | 2018-12-18 | 天津职业技术师范大学 | A kind of CA6140 Lathe Spindle Box teaching aid based on 3D printing |
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