CN104462650B - A kind of hypostazation heart 3D model production methods of achievable external and internal compositionses - Google Patents
A kind of hypostazation heart 3D model production methods of achievable external and internal compositionses Download PDFInfo
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Abstract
The present invention relates to the hypostazation heart 3D model production methods of achievable heart external and internal compositionses, the defect of prior art can be overcome, 1, cardia scanning is carried out to patient, medical image data is obtained, DICOM file is formed；2nd, with the DICOM file in Mimics softwares identification step 1 and preservation, the .mcs files of computer identification are formed；3rd, different data templates are extracted in software；4th, template incomplete to the presence cavity structure or image in step 3 or obscure boundary Chu is handled, and makes template complete display；5th, the template by adding, deleting between each template, separation or merging formation need；6th, the 3D rendering formed in step 5 is handled, makes the integrality of 3D rendering outer smooth and internal image template, form stl file；7th, the data handled well in step 6 are imported in 3D laser printers, prints cardiac module, the present invention can obtain the complete cardiac module of clear in structure, can greatly improve the success rate of openheart surgery.
Description
Technical field
The present invention relates to cardiac module forming technique, the hypostazation heart 3D models of particularly a kind of achievable external and internal compositionses
Preparation method.
Background technology
Because the encipherment protection of CT and MRI workbenches is designed, the heart scanning diagnosis number for reading heart clinician
All it is 2-D data image and plane sectional drawing according to whether enhanced CT and MRI, lacks the sense of endocardial structural upright and lack hand
The data of art operating position measurement；General cardiac image research is simply rebuild in heart surface structure, is not included
Endomyocardial and cardiac valves, muscle column and chordae tendineae and the adipose tissue of covering, congenital complexity heart disease are pediatric cardiac hairs
Educate stage cardiomyocyte cell to make a variation during tissue disintegration, serious cardiac structure is produced after growth course and is changed and blood
Dynamics changes, influence infant survival state and disease cured probability；Complicated openheart surgery needs to carry out again cardiac structure
Build, including efferent tract, valve, chordae tendineae, interventricular septum or atrial septum etc., the physiology dissection of normal heart development of the same age is reached, it is existing
Stage Complex Congenital Heart Disease performs the operation cure rate well below other openheart surgeries, with the objective reproduction technology of its labyrinth and
Preoperative clear and definite conceptual design is relevant；So needing more accurately 3-D view and adjacent tissue's structure distance values measurement, directly
Connect the research of observation individuation heart disease progress operation prescheme has great need to shortening operating time and improving cure rate
Ask；Hypostazation heart 3D models be surgical doctor intentionally get instruct operation model.
Existing technical problem is that computer simulation medical 3 D imaging technique cognition degree is shallow, and most doctors do not have
Such technology is contacted, it is main at this stage imaging arrangement is simple, the exploratory clinical practice of the uncomplicated field of orthopaedics of relation is instructed；
Heart tissue structure is complicated, close relation, is generally used as general image and extracts research, endocardial tissue is not shown
Structure and position relationship, and prior art has the following disadvantages；
1st, Enhanced CT cardiac data extracts that inaccurate to often result in image procossing incomplete（Due to scanning tomography thickness and
Heartbeat is relevant）；
2nd, heart tissue relation is complicated, and substantially, intricate each other, computer is respectively organized at each position to individuation difference
Each position not easy to identify changes situation, causes cardiac image to be difficult a wide range of computer segmentation, and most steps need experiment
And clinical staff carries out manual intervention；
3rd, endocardial extracts complicated, and contrast agent heart skewness causes internal imaging more complicated；
4th, atrial wall is than relatively thin, and average 1 ~ 3mm easily forms image slices；
5., DICOM data imaging form boundary distortions, result in and be difficult to observe each position line of demarcation；
6th, computer complex operations 3D model imagings；
7th, 3D printing material is selected, and printed material is usually the conventional material of engineering field at this stage, and cardiac three-dimensional is rebuild
It is primarily to see internal structure, material selection that is more transparent, more soft, being adapted to ergonomic suppleness is material needs at this stage
The technical disadvantages of solution.
Therefore, individuation, the heart 3D model production methods of hypostazation and the printing of 3D models are the medical science sides of urgent need to resolve
Face problem.
The content of the invention
For above-mentioned situation, to overcome the problem of prior art, the new measuring method of exploration and model production method, promote
Medical 3 D reconstruction technique and cardiac three-dimensional are rebuild and the printing of 3D models, and the present invention proposes a kind of achievable heart external and internal compositionses
Hypostazation heart 3D model production methods, complete the display of endocardial clear in structure completely.
Its method is：
Step 1, enhanced CT, MRI scan：Complete contrast agent filling is carried out to heart of patient, CT scan thickness is
0.9mm, number of sections carry out cardia scanning for enhanced CT, MRI under conditions of 150 to 200 layers to patient, obtain medical science
Image data, is divided into 0.45mm thickness by image thickness using workbench, forms DICOM file again；
Step 2, extraction data：By the data DICOM format file export obtained by scanning in step 1, Mimics softwares are used
Recognize and preserve, form the .mcs new files of computer identification；
Step 3, formation template：DICOM data are handled in Mimics softwares, it is former according to CT and MRI imaging
Reason, different data templates are extracted in the range of the different tissues mask of Mimics softwares；
Step 4, template reparation：Can have that cavity structure or image be not complete in the template extracted in step 3 or border not
The problem of understanding, is handled above mentioned problem through Mimics softwares, makes template complete display；
Step 5, editing template generation " lesion " template：In Mimics softwares, area of computer aided craft editing template behaviour
Make, complete cardiovascular system roughly and fine segmentation, formation includes internal chambers of the heart contrast agent template, each position cardiac muscle template and covered
The fatty template of lid；Pass through the template mutually added, deleted between each template, separation or combining step formation need；
Step 6, optimization image：The 3D rendering formed in step 5 is handled through PaintShop, made outside 3D rendering
Portion is smooth and ensures the integrality of internal image template, and forms general printing identification stl file；
Step 7,3D printing model：The data handled well in step 6 are imported in 3D laser printers, suitable material is selected
Material prints cardiac module.
The present invention can obtain the complete cardiac module of clear in structure, can greatly improve the success rate of openheart surgery.
Embodiment
The present invention is described in further detail below.
The present invention step be：
Step 1, enhanced CT, MRI scan：Complete contrast agent filling is carried out to heart of patient, CT scan thickness is
0.9mm, number of sections carry out cardia scanning for enhanced CT, MRI under conditions of 150 to 200 layers to patient, obtain medical science
Image data, is divided into 0.45mm thickness by image thickness using workbench, forms DICOM file again；（Need the layer of minimum
Thick routine 0.9mm now needs workbench to be split into 0.45mm）
Step 2, extraction data：By the data DICOM format file export obtained by scanning in step 1, Mimics softwares are used
Recognize and preserve, form the .mcs new files of computer identification；
Step 3, formation template：DICOM data are handled in Mimics softwares, it is former according to CT and MRI imaging
Reason, different data templates are extracted in the range of the different tissues mask of Mimics softwares；
Step 4, template reparation：Can have that cavity structure or image be not complete in the template extracted in step 3 and border not
The problem of understanding, is handled above mentioned problem through Mimics softwares, makes template complete display；
Step 5, editing template generation " lesion " template：Area of computer aided craft editing template operation, completes cardiovascular system
Roughly and fine segmentation, formation includes internal chambers of the heart contrast agent template, the myocardium template in each position and covering fat template to system；Pass through
Mutually add, delete between each template, separation or combining step form the template needed；Described " lesion " template refers to include
The template of the anatomical structure of depauperation and defect.
Step 6, optimization image：The 3D rendering formed in step 5 is handled through PaintShop, made outside 3D rendering
Portion is smooth and ensures the integrality of internal image template, and forms general printing identification stl file；
Step 7,3D printing model：The data handled well in step 6 are imported in 3D laser printers, heart is printed
Model.
Each step is further explained below：
Enhanced CT and MRI image scan process
This step needs completely and the heart surface sweeping data of high definition, and accurate scan image is very heavy to data and image processing
The step of wanting, enhanced CT and MRI need image to keep clear, reduce patient's physiological activity and are mainly lung's respiratory movement and heart
Beat the shade produced, reduce the disturbing factor such as noise of equipment and spot, cardiac CT scan thickness is that 0.9mm, number of sections are
150 to 200 layers, enhanced CT and MRI carry out complete contrast agent to look-out station and filled, to show most clear diseased region
And anatomy relationship；Required contrast agent and injection speed has to comply with《Clinical technique specification》With《Image technology fascicle》
Requirement, according to patient age and need the different contrast agent demand of observation lesion, injection speed, scan setting also to differ；Make
Site heart Structure Comparison of the shadow agent first Jing Guo lesion shows most clear, it is necessary to determine to complete CT scan on this node；Such as
It is poor that one circulation of fruit completion often leads to Structure Comparison；By the medical image data of acquisition, it will be schemed using workbench
As thickness is divided into 0.45mm thickness again, DICOM file is formed；Need the thickness of minimum：Present conventional layer thickness 0.9mm needs work
0.45mm thickness is split into as platform.
Extract data：
Extract data and CT and MRI primitive medicine image data is mainly imported into Mimics by DICOM file form
Software, preserves the MCS file that can be recognized by Mimics softwares, and medical data is converted into the file of common computer identification, " carried
Access evidence " extract is lesion medical science position picture number of plies scope；Whole CT information of look-out station will be included by extracting data,
Heart is general to be extracted between arch of aorta layer and apex of the heart layer, can be extracted the corresponding CT numbers of plies according to observation diseased region and be reduced
Workload and image complexity.
Form template
CT and MRI scan process are that whole thorax is carried out into tomoscan, form complete chest medical image, but
It is that this method only needs to the medical image of heart, so only needing to the position of cardiac data " heart " alternatively, other portions
Position imaging is serious disturbing factor, it is necessary to which they are deleted from template image.
Mimics or with the image-forming principle of the medical treatment software of Mimics identity functions according to CT and MRI, according to difference
Window is organized to extract, the agent of chambers of the heart interimage, each chamber cardiac muscle, covering fat etc. can be included by extracting data, obtain different
The cardiac templates of form template.
Template is repaired
Each template endocardial formed in " formation template " step can form cavity, and formation is that contrast agent template is carried
Take to form internal cavity structures, integrative medicine knowledge rejects interference images, or contrast agent is shown not in blood fortune in heart
Cause image incomplete clearly.
Producing reason；Endocardial image is usually to improve heart chamber density using heart contrast agent in circulating, with
Blood circulation and assemble in heart and form high-density region, it is uneven that circulation often leads to contrast agent filling, and is tied in the chambers of the heart
Structure complexity has muscle bundle, and the labyrinth such as valve and efferent tract, because the formation of contrast agent template is not complete, often forms template cavity effect
Should, complex region shows incomplete.
The standard of reparation is：Carried out according to medical knowledge according to anatomy between repairing image template, template without cavity
With other templates and the disturbing factor of medical image；Need to carry out successively separation internal cardiac contrast agent and retain normal structure knot
Structure is, it is necessary to which the position of printing is recognized by template, specially：
1st, template keeps template image in the region of selection completely, uniformly；
2nd, different parts formation different templates avoid interference；
3rd, diseased region perfection is presented, and reduces interference, retains normal organization；
Solve to need to reach requirement according to professional knowledge repairing CT and MRI imagings are imperfect.
Optimize image
In the data treated using Photoshop softwares or maya softwares or other similar softwares in last step,
By systemic circulatory system and systemic pulmonary circulation carry out it is respectively different mark, because computer medical image is mainly by countless
Individual triangle sets are into its template progress smooth treatment, the standard of processing is：
Firstth, make template more smooth by increasing template and reduction template；
Secondth, the not complete and defect of three-dimensional template image is handled by increasing and reducing triangle number and shape.
3D printing
Entered using conventional laser 3D printing, heart printing needs complete and accurate model, heart 3D model translucency
The higher the better, it is easier to convenient observation internal structure, material must have certain pliability, it is therefore desirable to reach Human vascular and
The degree of atrial wall, the pliability and fragility of ventricle wall so carry out operation stitching in model and cutting feel can be directly perceived, now
Using photosensitive resin material, medical grade silicon rubber or polymeric biomaterial.
The present invention concrete operations be：
Preparatory stage：1st, practice patient respiration and main points of holding one's breath, reduce respiratory movement thorax shade formation interference cardiac imaging；
2nd, iodine contrast medium prepares the 4h fasting before inspection.
First, enhanced CT, MRI scan medical data stage
Enhanced CT, MRI scan：Contrast agent filling is carried out to heart of patient, CT scan thickness is that 0.9mm, number of sections are
Enhanced CT, MRI carry out cardia scanning to patient under conditions of 150 to 200 layers, obtain medical image data, use work
Make platform and image thickness is divided into 0.45mm thickness again, form DICOM file；Need the present routine 0.9mm of thickness of minimum
Workbench is needed to be split into 0.45mm.
2nd, cardiac templates are extracted, are imaged and the 3D printing stage
1st, cardiovascular system data are imported：CT and MRI workbenches scan cardiovascular system, DICOM formatted datas according to
In secondary importing Mimics softwares, view directions, Organize Images order of the diseased region in Mimics softwares are determined
Number of plies scope where lower selection lesion determines the image position needed and preserved.
2nd, CT numerical value shows 256 gray values：The multi-level accurate observation of multiple location can not be formed, passes through Mimics softwares
In the colored collection of illustrative plates of Pseudo colors orders display, each position form situation of change of amplifying observation heart observes each tissue
Form and tissue, extent of disease and border condition；Using Mimics or with the medical treatment software of Mimics identity functions according to
CT and MRI image-forming principle, according to different tissues template areas imaging using Profile Line/ formation template scope or
Measure Density inside Ellipse/ region templates scopes or adjusting template scope send Visual Observations Observations border to cover feelings
Condition, the agent of chambers of the heart interimage, each chamber cardiac muscle, covering fat etc. can be included by extracting data, obtain the heart of different form templates
Template.
3rd, it is partitioned into cardiovascular system region：Profile line orders setting-out in Mimics softwares determines selection
Measure Density inside Rectang orders in the template window or Mimics softwares of extract part pass through
Square frame tissue average seeks then window；Through the recycling region growing in Mimics softwares（regiongrowing ）And
Dynamic area grows（dynamic region growing）Algorithm carries out coarse segmentation to target area.
4th, image disruption factor is deleted：Utilize editor（Edit）Function carries out fine segmentation, to clear display cardiovascular system
System various pieces, be specially：
A, deletion external interference factor：Heart contrast agent density has the window of intersection, cardiac muscle, fatty group with bone density
The institutional framework that being woven in same aspect has similar area intersects, and mainly removes manubrium, thorax, descending aorta and backbone,
Template image is caused to include unwanted structure because window is interlaced；1. in remote use Mimics softwares
Crop Mask orders unwanted template part is deleted by drawing the line；2. through Calculate polylines orders
The three-dimensional of generation carries out marking unwanted scope by hand, delete should not part；3. computer be unable to recognition template intersect away from
From near position should in the presence of 8 ~ 16 times of magnifying glass artificial recovery template.
B, repairing internal structure disturbing factor：Heart contrast agent heart Assembled distribution is uneven, and chambers of the heart inner structure is complicated, there is flesh
The labyrinths such as post, muscle bundle, papillary muscle, valve and efferent tract influence and the interference contrast agent filling chambers of the heart；Because contrast agent is uneven
It is even, template formed it is imperfect cause said structure border to show unclear, use editor（Edit）Function carries out fine segmentation, by hand
Operation and computer command, which cooperate, successively to be completed template extraction, repairs；Separate chambers of the heart cardiac contrast agent and retain normal group
Structure is knitted, is accurately extracted so as to eliminate interference that contrast agent is imaged to endocardial and complete internal pathological structure；Run " ripple
You " operational formula template is carried out " plus ", " subtracting " or " mergings " associative operation obtain the templates of needs.
5th, " bohr " operational formula template is mutually merged and deleted：The cardiac templates being related to " are subtracted into " contrast agent template
Formation needs the cardiac templates of the chambers of the heart.
6th, the template of different parts is merged into same template and smooth treatment is carried out with smooth orders and net is divided
Lattice handle 3-matic；Zbrush engraving softwares can also complete internal and surface smooth treatment image.
7th, Calculate 3D formation electronic 3-D model data STL+.
8th, in Geomagic Studio, obvious noise point is deleted manually with visual observations method, is then recycled and is reduced
Noise instrument, selects free form surface shape, smoothness is horizontally placed at into by-level, iterations is 3, and deviation is limited to
9.4647（Can freely it be set according to image clearly degree）Geomagic recognizes stl files, can observe internal structure and enter
Row DATA REASONING.
9th, image re-optimization：Using image processing software Photoshop and three-dimensional software 3ds Max, by what is rebuild
Heart surface model and cardiac muscle vascular surface, which are imported into 3ds Max, carries out post-processing, including model is arranged, texture
Mapping, sets up vascular pattern, bakees and output light textures.
10th, heart disease position perspective is beneficial to observation：With maya softwares or Geomagic softwares measurement endocardial.
11st, 3D models：If necessary to an only printing diseased region, computer picture segmentation software can be used, such as mimics softwares,
Maya softwares, Zbrush engraving softwares or Geomagic softwares carry out dividing processing to the 3D data of formation, are partitioned into needs
Diseased region.
12nd, 3D printing prototype printing medical science stl file：Cardiac module not only needs inner membrance, and also outer membrane includes two layers
Muscle between film, 3D printing only recognizes simple inside and outside two membranes, intermediate structure nonrecognition, and this is 3D printing " hollow out " effect
Should, carry out upset contrary operation or filled up with software.
13rd, the laser printing of heart stl file, solidification and formation model.
The present invention realizes cardiac image research at this stage does not only include outer membrane and cardiac muscle in cardiac intima structural remodeling
And the adipose tissue conversion of covering, realize and designed from routine experimentation to instructing clinical guidance to change, be specially：
1st, complicated cardiac structure is changed from medical image to computer picture,
2nd, complicated cardiac computer 3D rendering is set up and generation stl file,
3rd, the complicated heart stl file of 3D printing identification, produces and generates 3D cardiac modules.
The 3-D view that image data is converted into being recognized by computer by the present invention can be measured arbitrarily, can not only be taken off
From the limitation of workbench, and add the support medical image that common computer auxiliary software can be more perfect；Pass through three-dimensional
Image software combination 3D printing technique, the 3D models of manufacture can more intuitively observe diseased region, make the medical science of digital field
Image is converted into the cardiac module of material object；Preoperative preview, mutually can be completed by the lesion observation and research on 3D models
Simulate Operation cooperation；More intuitively, the cardiac module of apparent, complete individuation is redeveloped into openheart surgery and is ready, and builds
Postoperative complication can be reduced and shorten operating time by founding complete cardiac three-dimensional image, can greatly ensure the success rate of operation,
Reduce risks, be the innovation on heart printing technique.
Comprehensively cardiac three-dimensional image computer image of the invention can be used with the limitation of detachment system encrypted work platform
CASE(Computer Aided Software Engineering) can complete series of steps operation：Such as heart four-dimensional imaging, openheart surgery animation demonstration or heart
Operation computer simulation etc. can build good platform for cardiac computer auxiliary.
The beneficial effects of the invention are as follows：
1st, it is that cardiac computer technology builds a platform to form cardiac computer model
2nd, 3D printing model from medical science material object it is upper can directly from lesion, increase three-dimensional stereopsis and in kind feel and handle
Imagination image in brain becomes in face of material object is presented in.
The present invention has widened the level of understanding of anatomy cardiac field, and individual calculus is gone to from the image plane of workbench
The three-dimension layer foliation solution of machine, and can simple complete independently operating procedure, and promoted medical 3 D reconstruction technique and
Cardiac three-dimensional is rebuild and 3D model printing techniques.
Claims (4)
1. a kind of hypostazation heart 3D model production methods of achievable external and internal compositionses, its step is：
Step 1, enhanced CT, MRI scan：Complete contrast agent filling is carried out to heart of patient, CT scan thickness is 0.9 mm, cut
Piece quantity carries out cardia scanning for enhanced CT, MRI under conditions of 150 ~ 200 layers to patient, obtains medical image data,
Image thickness is divided into 0.45 mm thickness again using workbench, DICOM file is formed；
Step 2, extraction data：By the DICOM format data obtained by step 1 enhanced CT, MRI workbenches scanning cardiovascular system
Import successively in Mimics softwares, determine view directions, Organize Images order of the diseased region in Mimics softwares
Number of plies scope where lower selection lesion determines the image position needed, forms the .mcs new files of computer identification and preserves；
Step 3, formation template：CT numerical value shows 256 gray values, it is impossible to forms the multi-level accurate observation of multiple location, passes through
The collection of illustrative plates of Pseudo colors orders display colour in Mimics softwares, each position form change feelings of amplifying observation heart
Condition, observes each tissue form and tissue, extent of disease and border condition；It is former according to CT and MRI imaging using Mimics softwares
Reason, Profile Line/ formation template scopes or Measure Density are used according to different tissues template areas imaging
Inside Ellipse/ region templates scopes or adjusting template scope send Visual Observations Observations border coverage condition, and extracting data can be with
Including the agent of chambers of the heart interimage, each chamber cardiac muscle, covering fat, the cardiac templates of different form templates are obtained；
Step 4, template reparation：Profile line order setting-outs first in Mimics softwares determine selective extraction position
Template window or Mimics softwares in Measure Density inside Rectang orders pass through square frame tissue
Average seeks then window；
Step 5, editing template generation " lesion " template：It is partitioned into cardiovascular system region：Through sharp again in Mimics softwares
Use region growing（regiongrowing ）And dynamic area growth（dynamic region growing）Algorithm is to target area
Domain carries out coarse segmentation, is partitioned into cardiovascular system region；Delete image disruption factor：Utilize editor（Edit）Function carries out essence
Subdivision is cut, and to clear display cardiovascular system various pieces, is specially：
A, deletion external interference factor：Heart radiography density has the window of intersection with bone density, and cardiac muscle, adipose tissue are same
The institutional framework that aspect has similar area intersects, and mainly removes manubrium, thorax, descending aorta and backbone, due to regarding
Window scope is interlaced to cause template image to include unwanted structure：The Crop in remote use Mimics softwares
Mask orders are deleted unwanted template part by drawing the line；To being generated through Calculate polylines orders
3-D view, mark unwanted scope by hand, delete should not part；Computer is unable to recognition template cross distance
Near position should in the presence of 8 ~ 16 times of magnifying glass artificial recovery template；
B, repairing internal structure disturbing factor：The aggregation of heart contrast agent heart is uneven, and internal cardiac structures are complicated, have muscle column, muscle bundle,
Papillary muscle, valve and efferent tract influence and the interference contrast agent filling chambers of the heart；Because contrast agent is uneven, template forms imperfect lead
Cause said structure border to show unclear, use editor（Edit）Function carries out fine segmentation, manual operations and computer command phase
Mutually coordinate and successively complete template extraction, repair；Isolating cardiac cardiac contrast agent retains normal organization, so as to eliminate radiography
The internal pathological structure of interference and completion that agent is imaged to endocardial is accurately extracted；" bohr " operational formula is run to carry out template
" plus ", " subtracting " or " merging " operation obtain need template；" bohr " operational formula template is mutually merged and deleted：It will be related to
Cardiac templates " subtract " contrast agent template formation need the cardiac templates of the chambers of the heart；
Step 6, optimization image：The 3D rendering formed in step 5 is handled through PaintShop, makes 3D rendering exterior light
Integrality that is sliding and ensureing internal image template, and general printing identification stl file is formed, it is specially, by different parts
Template merge to form same template and carried out with smooth orders smooth treatment and grid division processing 3-matic；Zbrush
Engraving software can also complete internal and surface smooth treatment image；, Calculate 3D formation electronic 3-D model data
STL+；, in Geomagic Studio, delete obvious noise spot manually with visual observations, then recycle and reduce noise
Instrument, selects free form surface character, smooth level is placed in into by-level, iterations is 3, and deviation is limited to 9.4647,
It can freely be set according to image clearly degree in the range of this, stl files are recognized using geomagic softwares, can observe interior
Portion's structure and progress DATA REASONING；, image re-optimization：Utilize image processing software Photoshop and three-dimensional software 3ds
Max, the heart surface model rebuild and cardiac muscle vascular surface are imported into 3ds Max and carry out post-processing, including
Model is arranged, texture mapping, sets up vascular pattern, is bakeed and output light textures；, heart disease position perspective be beneficial to observation：
With maya softwares or Geomagic softwares measurement endocardial；, 3D models：Only printing diseased region, can use computer picture
Segmentation software, Mimics softwares, maya softwares, Zbrush engraving softwares or Geomagic softwares are carried out to the 3D data of formation
Dividing processing, is partitioned into the diseased region of needs；, 3D printing prototype printing medical science stl file：Cardiac module is not only needed
Inner membrance is wanted, also external mold includes the muscle between two membranes, and 3D printing only recognizes simple inside and outside two membranes, and intermediate structure is failed to see
Not, this is 3D printing " hollow out " effect, carries out upset contrary operation or is supplemented with software；
Step 7,3D printing model：The data handled well in step 6 are imported in 3D laser printers, cardiac module is printed.
2. the hypostazation heart 3D model production methods of achievable external and internal compositionses according to claim 1, it is characterised in that
Described extraction data are, by DICOM file form importing Mimics softwares, to protect CT and MRI primitive medicine image data
The MCS file that can be recognized by Mimics softwares is deposited, medical data is converted into the file of common computer identification, " extraction data "
What is extracted is the picture number of plies scope at lesion medical science position；Whole CT information of look-out station will be included by extracting data, and heart exists
Extracted between arch of aorta layer and apex of the heart layer, reduce workload according to the corresponding CT numbers of plies of observation diseased region extraction and image is multiple
Miscellaneous degree.
3. the hypostazation heart 3D model production methods of achievable external and internal compositionses according to claim 1, it is characterised in that
Described formation template is CT and MRI scan process is that whole thorax is carried out into tomoscan, forms complete chest medical science figure
As data, but only that the medical image of heart, it is only necessary to the position of cardiac data " heart " alternatively, other positions
Imaging is serious disturbing factor, it is necessary to which they are deleted from template image；Mimics softwares are former according to CT and MRI imaging
Reason, is extracted according to different tissues window, and the agent of chambers of the heart interimage, each chamber cardiac muscle, covering fat can be included by extracting data, be obtained
To the cardiac templates of different form templates.
4. the hypostazation heart 3D model production methods of achievable external and internal compositionses according to claim 1, it is characterised in that
The standard of described template reparation is the disturbing factor for not having cavity and other templates and medical image between template；Need to carry out
Successively separation internal cardiac contrast agent retains normal organization, it is necessary to which the position of printing is recognized by template, specially：
（1）Template keeps template image in the region of selection completely, uniformly；
（2）Different parts formation different templates avoid interference；
（3）Diseased region perfection is presented, and reduces interference, retains normal organization.
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| CA2659898C (en) | 2006-08-03 | 2017-08-29 | Christoph Scharf | Method and device for determining and presenting surface charge and dipole densities on cardiac walls |
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Effective date of registration: 20180410 Address after: 450000, Henan economic and Technological Development Zone, Zhengzhou Province Second Avenue West, south one South Road, Xinghua science and Technology Industrial Park, No. 2, building 8, No. 808 Patentee after: Henan dragon three dimensional Biological Engineering Co., Ltd. Address before: 450000 the six ward of the Seventh People's Hospital of Zhengzhou seventh, people's Hospital, Zhengzhou, Henan, 17. Patentee before: Zhang Jianqing |