CN105334243A - Blood analyzer - Google Patents
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- CN105334243A CN105334243A CN201410318293.8A CN201410318293A CN105334243A CN 105334243 A CN105334243 A CN 105334243A CN 201410318293 A CN201410318293 A CN 201410318293A CN 105334243 A CN105334243 A CN 105334243A
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Abstract
The present invention relates to a blood analyzer, including a mode selection unit, a measuring unit and a control unit. The mode selection unit is for selecting a measurement mode from a measurement mode set; and the measurement mode set comprises at least a whole blood CRP individual measurement mode. The control unit calls the corresponding module in the measurement unit for measurement according to the measurement mode selected by the mode selection unit. The measuring unit at least includes a hematocrit measurement module, a whole blood CRP measurement module and a correction module; the correction module corrects the whole blood CRP concentration obtained by the whole blood CRP measurement module according to the hematocrit value obtained by the hematocrit measurement module, so as to obtain corrected CRP concentration value. The blood analyzer can individually measure the whole blood CRP concentration values, only needs a small amount of blood to realize CRP concentration measurements and reduces the use amount of a hemolytic agent. The blood analyzer has the advantages of low cost, simple operation, and good application prospects, and can be used for clinical popularization and application.
Description
Technical field
The present invention relates to field of medical device, be specifically related to a kind of blood analyser.
Background technology
C reactive protein (C-reactiveprotein, the Acute phase protein of liver cell synthesis when CRP) to be that body is subject to microorganism invasion or tissue damage etc. is struvite stimulate, start a few hours CRP in inflammation just to raise, within 48 hours, get final product peaking, along with pathology disappears, tissue, normal level is down in the recovery of 26S Proteasome Structure and Function, the detection of CRP is quite extensive in clinical practice, comprise the diagnosis and differential diagnosis of acute infectious diseases, the monitoring of post-operative infection, the observation of microbiotic curative effect, course of disease detection and Index for diagnosis etc., therefore measure CRP concentration value in blood accurately, to clinical diagnosis, there is important value.
A kind of mode that current industry measures CRP concentration value measures CRP concentration value in serum, Jap.P. NO.11575/1983 discloses a kind of immune analysis method, the method utilizes the antigen on insolubles or antibody to be combined into the feature of agglutinator to the corresponding antibody on sample or antigen, re-use the light-wave irradiation coagulum of wavelength between 600nm-2400nm, obtain the parameter of antigen finally by the absorption (absorbance) or scattering (scattered) degree of analyzing light.But when adopting the method to carry out CRP test to serum, need to extract serum from whole blood, required test blood sample is also relatively large.
Another CRP concentration value measuring method adopts whole blood to measure, but when existing blood analyser adopts whole blood to measure CRP, can do routine blood test simultaneously and measure, like this, required test blood sample is also relatively large.
In sum, needed for existing CRP pick-up unit, blood sample is all relatively large, and for the patient, particularly pediatric patient of blood sampling difficulty, blood volume is little, is difficult to carry out the measurement of CRP concentration value.
Summary of the invention
For this reason, the present invention is directed to the problem that the required blood sample amount of existing CRP pick-up unit existence is larger, propose a kind of required blood analyser that blood volume is few, testing result can detect separately CRP concentration value accurately.
For solving the problems of the technologies described above, technical scheme of the present invention is as follows:
A kind of blood analyser, comprising:
Mode selecting unit, for selecting a kind of measurement pattern from measurement pattern set, at least comprises whole blood CRP independent measurement pattern in described measurement pattern set;
Measuring unit, at least comprises hematocrit measurement module, whole blood CRP measurement module and correcting module; The hematocrite value that described correcting module obtains according to described hematocrit measurement module is revised the whole blood CRP concentration value that whole blood CRP measurement module obtains, and obtains revised CRP concentration value;
Control module, when described mode selecting unit chooses whole blood CRP independent measurement pattern, calls described hematocrit measurement module, whole blood CRP measurement module and correcting module and carries out the measurement of CRP concentration value.
Preferably, one or more in CBC blood cell differential and CRP pattern, CBC blood cell differential measurement pattern, CBC measurement and CRP pattern are also comprised in described measurement pattern set.
Preferably, described measuring unit also comprises: BASO detection module, DIFF detection module, HGB detection module; Described BASO detection module is for detecting white blood cell count(WBC) and basophilic granulocyte classification, and described DIFF detection module is for detecting leucocyte four classification, and described HGB detection module is for detecting hemoglobin concentration.
Preferably, described measuring unit also comprises: white blood cell count(WBC) and three sort modules thereof and HGB detection module.
Preferably, described control module also comprises:
When described mode selecting unit chooses CBC blood cell differential measurement pattern, call described BASO detection module, DIFF detection module, HGB detection module and hematocrit measurement module and carry out CBC haemocyte five category measurement;
When described mode selecting unit chooses CBC blood cell differential and CRP pattern, call described BASO detection module, DIFF detection module, HGB detection module and hematocrit measurement module and carry out CBC haemocyte five category measurement, and call described hematocrit measurement module, whole blood CRP measurement module and correcting module and carry out the measurement of CRP concentration value;
When described mode selecting unit chooses CBC measurement and CRP pattern, call described BASO detection module, HGB detection module and hematocrit measurement module and carry out CBC measurement, and call described hematocrit measurement module, whole blood CRP measurement module and correcting module and carry out the measurement of CRP concentration value.
Preferably, described control module also comprises:
When described mode selecting unit chooses CBC blood cell differential measurement pattern, call described white blood cell count(WBC) and three sort modules, HGB detection module and hematocrit measurement module carry out CBC haemocyte three category measurement;
When described mode selecting unit chooses CBC blood cell differential and CRP pattern, call described white blood cell count(WBC) and three sort modules, HGB detection module and hematocrit measurement module carry out CBC haemocyte three category measurement, and call described hematocrit measurement module, whole blood CRP measurement module and correcting module and carry out the measurement of CRP concentration value.
Preferably, described whole blood CRP measurement module determines the dosage of added hemolytic agent according to the hematocrite value that described hematocrit measurement module records.
Preferably, described blood analyser also comprises test-types automatic selected cell, and described measuring unit also comprises serum CA125 measurement module;
Described test-types automatic selected cell when the hematocrite value that described hematocrit measurement module records is less than predetermined threshold value, judge to survey blood sample be serum or blood plasma, and call described serum CA125 measurement module and carry out the measurement of CRP concentration value; Otherwise judge to survey blood sample be whole blood, and call described whole blood CRP measurement module and correcting module carries out the measurement of CRP concentration value.
Preferably, described hematocrit measurement module is impedance measurement module.
Preferably, described impedance measurement module comprises liquid feeding dilution submodule, secondary liquid feeding dilution submodule, mixing submodule, impedance method Erythrocyte measure submodule and hematocrit calculating sub module.
Technique scheme of the present invention has the following advantages compared to existing technology: adopt and the invention provides blood analyser, can independent measurement whole blood CRP, measures, and can decrease the use amount of hemolytic agent as long as little blood volume can realize CRP concentration value.Adopt blood analyser provided by the invention generally only to need 15-25 μ L blood can complete the measurement of whole blood CRP, existing whole blood CRP concentration value measures the blood then generally needing 30-40 μ L.
Accompanying drawing explanation
In order to make content of the present invention be more likely to be clearly understood, below according to a particular embodiment of the invention and by reference to the accompanying drawings, the present invention is further detailed explanation, wherein
Fig. 1 is the structural representation of the blood analyser in the embodiment of the present invention 1;
Fig. 2 is the structural representation of the impedance measurement module of blood analyser in the embodiment of the present invention 1;
Fig. 3 is the workflow diagram of the blood analyser described in the embodiment of the present invention 1;
Fig. 4 is the structural representation of the blood analyser in the embodiment of the present invention 2;
Fig. 5 is the structural representation of the blood analyser in the embodiment of the present invention 3;
Fig. 6 is the structural representation of the blood analyser in the embodiment of the present invention 4;
Fig. 7 is the structural representation of the blood analyser in the embodiment of the present invention 5.
Embodiment
In order to make the object, technical solutions and advantages of the present invention clearly, below in conjunction with accompanying drawing, embodiments of the present invention are described in further detail.
embodiment 1
A kind of blood analyser is provided in the present embodiment, whole blood CRP concentration value can be measured.Owing to often using Serum CRP concentrations in the industry, in order to make whole blood CRP concentration value and Serum CRP concentrations value possess comparability, need the hematocrit information using whole blood sample, whole blood CRP test result is revised.The most frequently used modification method is;
CRP'＝CRP×100/(100-hematocrit％)
Wherein Hematocrit (being called for short HCT, hematocrite value) is the hematocrite value of whole blood sample, and CRP is that whole blood measures directly acquisition CRP concentration value, and CRP' is revised CRP concentration value.
The revised whole blood CRP concentration value obtained in this way and Serum CRP concentrations value have comparability.
The present embodiment provides a kind of blood analyser, as shown in Figure 1, comprises mode selecting unit 1, measuring unit 3 and control module 2.
Wherein, mode selecting unit 1, for selecting a kind of measurement pattern from measurement pattern set, in the present embodiment, measurement pattern set comprises whole blood CRP independent measurement pattern.
Measuring unit 3, comprises hematocrit measurement module 301, whole blood CRP measurement module 302 and correcting module 303.The hematocrite value that correcting module 303 records according to hematocrit measurement module 301 is revised the whole blood CRP concentration value that whole blood CRP measurement module 302 obtains, and obtains revised CRP concentration value.Here, concrete modification method is described above, repeats no more.
Control module 2, when mode selecting unit 1 selectes whole blood CRP independent measurement pattern, calls the hematocrit measurement module 301 in measuring unit 3, whole blood CRP measurement module 302 and correcting module 303 and carries out the measurement of CRP concentration value.Owing to only there being a kind of whole blood CRP independent measurement pattern in mode selecting unit in the present embodiment 1, therefore this blood analyser is only for whole blood CRP independent measurement.
Above-mentioned hematocrit measurement module 301 can be impedance measurement module, the structured flowchart of impedance measurement module as shown in Figure 2, comprises liquid feeding dilution submodule 3011, a secondary liquid feeding and dilutes submodule 3012, mixing submodule 3013, impedance method Erythrocyte measure submodule 3014 and hematocrit calculating sub module 3015.Wherein in a liquid feeding dilution submodule 3011, the amount of added dilution is 2500ul, and in secondary liquid feeding dilution submodule 3012, the amount of added dilution is 1650ul.Impedance measurement module, by the process of dilute twice, can make the sample total after diluting become large, reduce error.
The workflow of the blood analyser in the present embodiment as shown in Figure 3, process is as follows: user passes through mode selecting unit 1 after determining whole blood CRP measurement pattern, draw institute's test sample originally, sample is inhaled after sample completes and is carried out a point blood, blood sample is divided into two parts, a part carries out the measurement being carried out hematocrite value by impedance measurement module, and another part carries out the measurement of whole blood CPR concentration value by whole blood CRP measurement module.
The measuring process of hematocrite value comprises: first add dilution and dilute, be divided into dilute twice herein, after a liquid feeding dilution, the dilution of secondary liquid feeding, sample after dilution is mixed, Erythrocyte measure is carried out again by impedance method, calculate and obtain hematocrite value, English name Hematocrit, be called for short HCT value.
The measuring process of whole blood CRP concentration value comprises: first add hemolytic agent, then add latex reagent, after mixing, then is measured by immunoturbidimetry, then calculates and obtains CRP concentration value.
Finally, correcting module 303 is revised above-mentioned CRP concentration value according to HCT value obtained above, obtains revised CRP and exports, and namely completes the measurement of whole blood CRP concentration value.
A kind of blood analyser is provided in the present embodiment, can independent measurement whole blood CRP concentration value, measurement pattern is selected by mode selecting unit 1, achieve whole blood CRP independent measurement, without the need to measuring routine blood test, independent measurement hematocrite value and whole blood CRP concentration value, and the modified value being obtained whole blood CRP concentration by the method revised.In the program, due to without the need to measuring routine blood test, the only independent measurement value of hematocrit, make blood using amount less, as long as namely little blood volume can meet the demands, as the measurement only needing 15-25 microliters of blood can complete whole blood CRP, and completed the correction of whole blood CRP by hematocrite value, make this measured value and Serum CRP concentrations value have comparability, also improve its measuring accuracy simultaneously.Solve in prior art, measuring whole blood CRP needs to measure routine blood test, needs the problem that blood volume is large.This blood analyser financial cost is low, easy and simple to handle, has good application prospect, can be used for applying clinically.
embodiment 2
The blood analyser of the present embodiment, as shown in Figure 4, this blood analyser possesses three kinds of measurement patterns to its structural representation, and measurement pattern set comprises whole blood CRP independent measurement pattern, CBC blood cell differential and CRP pattern, CBC blood cell differential measurement pattern.Mode selecting unit 1 selects a kind of measurement pattern in the measurement pattern set that forms at above-mentioned Three models.
CBC full name is CompleteBloodCount, refer to total cell count, CBC measurement refers to measure WBC (whitebloodcel, leucocyte), RBC (Redbloodcel red blood cell), PLT (bloodplatelet, blood platelet), counting and the morphological parameters such as HGB (hemoglobin concentration), HCT (hematocrit).CBC blood cell differential can be divided into again CBC cell three-classification and CBC cell five classification.
In the present embodiment, measuring unit 3 comprises BASO detection module 304, DIFF detection module 305, HGB detection module 306, hematocrit measurement module 301, whole blood CRP measurement module 302 and correcting module 303.Wherein,
BASO detection module 304 is for detecting white blood cell count(WBC) and basophilic granulocyte classification;
DIFF detection module 305 classifies (lymph, monokaryon, neutral grain, acidophil granules) for detecting leucocyte four;
HGB detection module 306 is measured for detecting hemoglobin concentration;
Hematocrit detection module 301 is measured for detecting red blood cell and platelet count and morphological parameters;
Whole blood CRP measurement module 302 measures (Immunity transmission turbidity) for detecting c reactive protein;
Correcting module 303 is for revising the whole blood CRP concentration value recorded according to the hematocrite value recorded.
Control module 2, when mode selecting unit 1 chooses whole blood CRP independent measurement pattern, calls hematocrit measurement module 301, whole blood CRP measurement module 302 and correcting module 303 and carries out the measurement of CRP concentration value; When mode selecting unit 1 chooses CBC blood cell differential measurement pattern, call BASO detection module 304, DIFF detection module 305, HGB detection module 306 and hematocrit measurement module 301 and carry out CBC haemocyte five category measurement; When mode selecting unit 1 chooses CBC blood cell differential and CRP pattern, call BASO detection module 304, DIFF detection module 305, HGB detection module 306 and hematocrit measurement module 301 and carry out CBC haemocyte five category measurement, and call hematocrit measurement module 301, whole blood CRP measurement module 302 and correcting module 303 and carry out the measurement of CRP concentration value.Here, when carrying out the measurement of CRP concentration value at this moment, without the need to again measuring when calling hematocrit measurement module 301, only need to obtain the hematocrite value calculated when hematocrit measurement module 301 carries out CBC haemocyte five category measurement, correcting module 303 is revised the CRP concentration value recorded according to this hematocrite value obtained.
In three kinds of measurement patterns that this blood analyser provides, adopt whole blood CRP independent measurement pattern test needed for blood volume be 15-25 microlitre, adopt CBC blood cell differential and CRP pattern test needed for blood volume be 30-40 microlitre, adopt CBC blood cell differential measurement pattern test needed for blood volume be 15-35 microlitre.Can find out only measure CRP time required blood volume be only simultaneously measure CBC blood cell differential and CRP time half about, decrease blood using amount.
The measuring method of the blood analyser of the present embodiment, comprises the steps:
Select a kind of measurement pattern, in this measurement pattern, can be selected any one in whole blood CRP independent measurement pattern, CBC blood cell differential and CRP pattern, CBC blood cell differential measurement pattern.
(1) during elected middle whole blood CRP independent measurement pattern:
Control module 2 calls hematocrit measurement module 301, whole blood CRP measurement module 302 and correcting module 303 and measures;
After the call instruction of measuring unit 1 reception control unit 2, hematocrite value is obtained by hematocrit measurement module 301, whole blood CRP concentration value is obtained by whole blood CRP measurement module 302, then the hematocrite value that correcting module 303 obtains according to hematocrit measurement module 301 is revised the whole blood CRP concentration value that whole blood CRP measurement module 302 obtains, and obtains revised CRP concentration value.
(2) during elected middle CBC blood cell differential measurement pattern;
BASO detection module 304, DIFF detection module 305, HGB detection module 306 and hematocrit measurement module 301 that control module 2 calls in measuring unit 1 are measured, and obtain the measured value that CBC haemocyte five is classified.
(3) when choosing CBC blood cell differential and CRP pattern;
Call BASO detection module 304, DIFF detection module 305, HGB detection module 306, hematocrit measurement module 301, whole blood CRP measurement module 302 and correcting module 303 that control module 2 calls in measuring unit 3 are measured;
Measuring unit obtains by BASO detection module 304, DIFF detection module 305, HGB detection module 306, hematocrit measurement module 301 value that CBC haemocyte five is classified, and obtain whole blood CRP concentration value by whole blood CRP measurement module 302, directly call the hematocrite value that above-mentioned hematocrit measurement module 301 has obtained again, according to this hematocrite value, the whole blood CRP concentration value that whole blood CRP measurement module 302 obtains is revised by correcting module 303, obtain revised CRP concentration value.
embodiment 3
Blood analyser in the present embodiment, measurement pattern set is identical with embodiment 2, white blood cell count(WBC) and three sort modules 307, HGB detection module 306, hematocrit measurement module 301, whole blood CRP measurement module 302 and correcting module 303 is comprised, as shown in Figure 5 unlike measuring unit 3.What the present embodiment 3 and the difference CBC blood cell differential in the present embodiment of embodiment 2 were measured is CBC haemocyte three classification, and in embodiment 2 measurement of CBC blood cell differential be CBC haemocyte five classification.
In control module 2, when mode selecting unit 1 chooses whole blood CRP independent measurement pattern, identical with embodiment 2.When mode selecting unit 1 chooses CBC blood cell differential measurement pattern, call white blood cell count(WBC) and three sort modules 307, HGB detection module 306 and hematocrit measurement module 301 carries out CBC haemocyte three category measurement.When mode selecting unit 1 chooses CBC blood cell differential and CRP pattern, call white blood cell count(WBC) and three sort modules 307 thereof, HGB detection module 306 and hematocrit measurement module 301 carry out CBC haemocyte three category measurement, and call hematocrit measurement module 301, whole blood CRP measurement module 302 and correcting module 303 carry out the measurement of CRP concentration value, now when carrying out CRP concentration value and measuring, only need to obtain the hematocrite value that when carrying out CBC haemocyte three category measurement, hematocrit measurement module 301 has obtained when calling hematocrit measurement module 301, without the need to remeasuring.
Because the measurement of CBC blood cell differential has two kinds of modes, a kind of is CBC haemocyte five category measurement in embodiment 2, another kind is CBC haemocyte three category measurement in the present embodiment, measure according to often kind of CBC blood cell differential, the present invention can provide the blood analyser realizing its function, and person easy to use selects as required.
embodiment 4:
On the basis of above-described embodiment 2, in the present embodiment, measurement pattern set also comprises CBC and measures and CRP pattern, when adopting CBC measurement and CRP pattern to measure, only carries out CBC and measures and the measurement of CRP concentration value, do not measure CBC blood cell differential.
In the present embodiment, as shown in Figure 6, mode selecting unit 1 selects a kind of measurement pattern from measurement pattern set, and measurement pattern set comprises whole blood CRP independent measurement pattern, CBC blood cell differential and CRP pattern, CBC blood cell differential measurement pattern, CBC measurement and CRP pattern;
Measuring unit 3, comprises BASO detection module 304, DIFF detection module 305, HGB detection module 306, hematocrit measurement module 301, whole blood CRP measurement module 302 and correcting module 303.BASO detection module 304 is for detecting white blood cell count(WBC) and basophilic granulocyte classification, and DIFF detection module 305 is for detecting leucocyte four classification, and HGB detection module 306 is for detecting hemoglobin concentration.The hematocrite value that correcting module 303 obtains according to hematocrit measurement module 301 is revised the whole blood CRP concentration value that whole blood CRP measurement module 302 obtains, and obtains revised CRP concentration value.
Control module 2, according to measurement pattern selected in mode selecting unit 1, each the corresponding module called in measuring unit 3 is measured accordingly.Particularly:
When mode selecting unit 1 chooses whole blood CRP independent measurement pattern, call hematocrit measurement module 301, whole blood CRP measurement module 302 and correcting module 303 and carry out the measurement of CRP concentration value;
When mode selecting unit 1 chooses CBC blood cell differential measurement pattern, call BASO detection module 304, DIFF detection module 305, HGB detection module 306 and hematocrit measurement module 301 and carry out CBC haemocyte five category measurement;
When mode selecting unit 1 chooses CBC blood cell differential and CRP pattern, call BASO detection module 304, DIFF detection module 305, HGB detection module 306 and hematocrit measurement module 301 and carry out CBC haemocyte five category measurement, and call hematocrit measurement module 301, whole blood CRP measurement module 302 and correcting module 303 and carry out the measurement of CRP concentration value, now calling hematocrit measurement module 301 needs to obtain the hematocrite value that when carrying out CBC haemocyte five category measurement, hematocrit measurement module 301 has obtained;
When mode selecting unit 1 chooses CBC measurement and CRP pattern, call BASO detection module 304, HGB detection module 306 and hematocrit measurement module 301 and carry out CBC measurement, and call hematocrit measurement module 301, whole blood CRP measurement module 302 and correcting module 303 and carry out the measurement of CRP concentration value, now calling hematocrit measurement module 301 needs to obtain and carries out the hematocrite value that when CBC measures, hematocrit measurement module 301 has obtained.
Certainly, also can increase CBC and measure and CRP pattern on the basis of embodiment 1 or 3, its specific implementation is the same, repeats no more.
In a preferred embodiment, the hematocrite value that whole blood CRP measurement module 302 can also record according to hematocrit measurement module 301 determines the dosage of added hemolytic agent.Hematocrite value is larger, and required hemolytic agent is more, therefore selects the dosage of hemolytic agent according to the hematocrite value recorded in hematocrit measurement module 301, ensures the accuracy of measurement result while better can saving reagent.
embodiment 5:
The blood analyser of the present embodiment also has following test-types automatic selected cell 4, can realize processing respectively whole blood and serum or blood plasma.
Blood analyser in the present embodiment, on the basis of embodiment 1, also comprise test-types automatic selected cell 4, measuring unit 3 also comprises serum CA125 measurement module 308, and structural representation as shown in Figure 7.Test-types automatic selected cell 4 when the hematocrite value that hematocrit measurement module 301 records is less than predetermined threshold value, judge to survey blood sample be serum or blood plasma, and call serum CA125 measurement module 308 and carry out the measurement of CRP concentration value; Otherwise judge to survey blood sample be whole blood, and call whole blood CRP measurement module 302 and correcting module 303 carries out the measurement of CRP concentration value.
Above-mentioned predetermined threshold value device as required, such as predetermined threshold value can be set to 0, or a less value such as 0.0001.Suppose that predetermined threshold value is 0, when the hematocrit numerical value that hematocrit measurement module 301 calculates acquisition is 0, test-types automatic selected cell 4 can judge that surveyed blood sample is serum or blood plasma; Calculate the hematocrit numerical value that obtains when not being 0, test-types automatic selected cell 4 can judge that surveyed blood sample is whole blood, then measures according to judged result selection whole blood CRP measurement module 302 or serum CA125 measurement module 308.
When hematocrite value is 0, judging that sample to be tested is serum or blood plasma, at this moment in measuring unit 3, select serum CA125 measurement module 308 pairs of samples to measure, without the need to adding hemolytic agent, also without the need to revising, can directly obtain Serum CRP concentrations value.When the value of hematocrit is not 0, judge that sample is whole blood, according to the hematocrite value that hematocrit measurement module 301 records, and call whole blood CRP measurement module 302 and correcting module 303 is measured, now need to add hemolytic agent, measured value before the whole blood CRP concentration correction obtained, and then through correcting module 303 revise after obtain revise after whole blood CRP concentration value.Now, whole blood CRP measurement module 302 is when adding hemolytic agent, and the size of the hematocrite value that can record according to hematocrit measurement module 301 further selects the amount of required hemolytic agent, if this value is larger, required hemolytic agent is more, and this value is less, and required hemolytic agent is fewer.So just, can reasonably select hemolytic agent number, ensure measuring accuracy and save reagent.
The blood analyser of the program can also adopt impedance method to measure hematocrite value, whether the numerical value determining hematocrit is 0, thus judging for serum or whole blood blood sample, adopt optimum mode to measure, thus improve measuring accuracy and save reagent dosage.This impedance method comprises once dilutes module and secondary dilution module, by repeatedly diluting, a small amount of sample is made to expand to suitable degree, because sample size is too little, larger error may be caused to occur, by the mode of secondary dilution, make the degree that sample total reaches certain, be conducive to like this improving accuracy of detection.
In other implementation, this blood analyser, can also three kinds of measurement patterns below as required on the basis comprising whole blood CRP independent measurement pattern: CBC blood cell differential and CRP pattern, CBC blood cell differential measurement pattern, CBC measure and select one or more to carry out combination in any in CRP pattern.
Obviously, above-described embodiment is only for clearly example being described, and the restriction not to embodiment.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here exhaustive without the need to also giving all embodiments.And thus the apparent change of extending out or variation be still among the protection domain of the invention.
Claims (10)
1. a blood analyser, is characterized in that, comprising:
Mode selecting unit, for selecting a kind of measurement pattern from measurement pattern set, at least comprises whole blood CRP independent measurement pattern in described measurement pattern set;
Measuring unit, at least comprises hematocrit measurement module, whole blood CRP measurement module and correcting module; The hematocrite value that described correcting module obtains according to described hematocrit measurement module is revised the whole blood CRP concentration value that whole blood CRP measurement module obtains, and obtains revised CRP concentration value;
Control module, when described mode selecting unit chooses whole blood CRP independent measurement pattern, calls described hematocrit measurement module, whole blood CRP measurement module and correcting module and carries out the measurement of CRP concentration value.
2. blood analyser according to claim 1, is characterized in that, also comprises one or more in CBC blood cell differential and CRP pattern, CBC blood cell differential measurement pattern, CBC measurement and CRP pattern in described measurement pattern set.
3. blood analyser according to claim 2, is characterized in that, described measuring unit also comprises: BASO detection module, DIFF detection module, HGB detection module; Described BASO detection module is for detecting white blood cell count(WBC) and basophilic granulocyte classification, and described DIFF detection module is for detecting leucocyte four classification, and described HGB detection module is for detecting hemoglobin concentration.
4. blood analyser according to claim 2, is characterized in that, described measuring unit also comprises: white blood cell count(WBC) and three sort modules thereof and HGB detection module.
5. blood analyser according to claim 3, is characterized in that, described control module also comprises:
When described mode selecting unit chooses CBC blood cell differential measurement pattern, call described BASO detection module, DIFF detection module, HGB detection module and hematocrit measurement module and carry out CBC haemocyte five category measurement;
When described mode selecting unit chooses CBC blood cell differential and CRP pattern, call described BASO detection module, DIFF detection module, HGB detection module and hematocrit measurement module and carry out CBC haemocyte five category measurement, and call described hematocrit measurement module, whole blood CRP measurement module and correcting module and carry out the measurement of CRP concentration value;
When described mode selecting unit chooses CBC measurement and CRP pattern, call described BASO detection module, HGB detection module and hematocrit measurement module and carry out CBC measurement, and call described hematocrit measurement module, whole blood CRP measurement module and correcting module and carry out the measurement of CRP concentration value.
6. blood analyser according to claim 4, is characterized in that, described control module also comprises:
When described mode selecting unit chooses CBC blood cell differential measurement pattern, call described white blood cell count(WBC) and three sort modules, HGB detection module and hematocrit measurement module carry out CBC haemocyte three category measurement;
When described mode selecting unit chooses CBC blood cell differential and CRP pattern, call described white blood cell count(WBC) and three sort modules, HGB detection module and hematocrit measurement module carry out CBC haemocyte three category measurement, and call described hematocrit measurement module, whole blood CRP measurement module and correcting module and carry out the measurement of CRP concentration value.
7., according to the arbitrary described blood analyser of claim 1-6, it is characterized in that, the hematocrite value that described whole blood CRP measurement module also records according to described hematocrit measurement module determines the dosage of added hemolytic agent.
8. blood analyser according to claim 7, is characterized in that, described blood analyser also comprises test-types automatic selected cell, and described measuring unit also comprises serum CA125 measurement module;
Described test-types automatic selected cell when the hematocrite value that described hematocrit measurement module records is less than predetermined threshold value, judge to survey blood sample be serum or blood plasma, and call described serum CA125 measurement module and carry out the measurement of CRP concentration value; Otherwise judge to survey blood sample be whole blood, and call described whole blood CRP measurement module and correcting module carries out the measurement of CRP concentration value.
9., according to the arbitrary described blood analyser of claim 1-6, it is characterized in that, described hematocrit measurement module is impedance measurement module.
10. measurement mechanism according to claim 9, it is characterized in that, described impedance measurement module comprises liquid feeding dilution submodule, a secondary liquid feeding and dilutes submodule, mixing submodule, impedance method Erythrocyte measure submodule and hematocrit calculating sub module.
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| CN112305244A (en) * | 2019-07-30 | 2021-02-02 | 深圳迈瑞生物医疗电子股份有限公司 | Sample analysis method, data management device, computer device, and storage medium |
| CN112798799A (en) * | 2019-11-13 | 2021-05-14 | 深圳迈瑞生物医疗电子股份有限公司 | Sample analysis system and sample testing method |
| CN113049801A (en) * | 2019-12-28 | 2021-06-29 | 深圳市帝迈生物技术有限公司 | Immunoassay analyzer |
| CN113049800A (en) * | 2019-12-28 | 2021-06-29 | 深圳市帝迈生物技术有限公司 | Immunoassay analyzer, detection method thereof and computer readable storage medium |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6106778A (en) * | 1997-09-27 | 2000-08-22 | Horiba, Ltd. | Blood cell count/immunoassay apparatus using whole blood |
| CN101680876A (en) * | 2007-03-22 | 2010-03-24 | 商诊疗有限公司 | Whole blood assay |
| US8101065B2 (en) * | 2009-12-30 | 2012-01-24 | Lifescan, Inc. | Systems, devices, and methods for improving accuracy of biosensors using fill time |
| CN103278439A (en) * | 2007-02-01 | 2013-09-04 | 希森美康株式会社 | Sample analyzer and control system thereof |
-
2014
- 2014-07-04 CN CN201410318293.8A patent/CN105334243A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6106778A (en) * | 1997-09-27 | 2000-08-22 | Horiba, Ltd. | Blood cell count/immunoassay apparatus using whole blood |
| CN103278439A (en) * | 2007-02-01 | 2013-09-04 | 希森美康株式会社 | Sample analyzer and control system thereof |
| CN101680876A (en) * | 2007-03-22 | 2010-03-24 | 商诊疗有限公司 | Whole blood assay |
| US8101065B2 (en) * | 2009-12-30 | 2012-01-24 | Lifescan, Inc. | Systems, devices, and methods for improving accuracy of biosensors using fill time |
Non-Patent Citations (3)
| Title |
|---|
| HORIBA ABX: "《ABX Micros CRP 200 Technical manual》", 27 September 2009 * |
| 甄萍 等: "《全血C_反应蛋白快速检测的应用》", 《临床血液学杂志》 * |
| 黄宇烽，李克: "《现代临床检验诊断手册》", 31 May 2006, 第二军医大学出版社 * |
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