CN105311750A - Sacral nerve stimulation system - Google Patents

Sacral nerve stimulation system Download PDF

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Publication number
CN105311750A
CN105311750A CN201510756358.1A CN201510756358A CN105311750A CN 105311750 A CN105311750 A CN 105311750A CN 201510756358 A CN201510756358 A CN 201510756358A CN 105311750 A CN105311750 A CN 105311750A
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module
stimulator
program control
communication module
control instrument
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CN201510756358.1A
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CN105311750B (en
Inventor
夏斌
丁皓
李晓波
王松
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HANGZHOU CHENGNUO MEDICAL TECHNOLOGY Co Ltd
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HANGZHOU CHENGNUO MEDICAL TECHNOLOGY Co Ltd
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Publication of CN105311750A publication Critical patent/CN105311750A/en
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Abstract

The invention discloses a sacral nerve stimulation system, which comprises an implanted nerve stimulator, a stimulator programmed controller and a stimulating electrode, wherein the implanted nerve stimulator comprises a MCU (micro-programmed control unit) control module, a special chip, a protection circuit module, a power management module and a radio frequency communication module; the stimulator programmed controller comprises an ARM control module, a USB communication module, a charger module, a medical implanted equipment special communication module, a storage module, a display module and a key module; the stimulating electrode is connected to the special chip; and sacral nerves are directly stimulated after a stimulating pulse is received. The implant stimulator disclosed by the invention, by generating lasting electric pulse, can conduct electric stimulation on target nerves in a plurality of parts; the implant stimulator is controlled by the stimulator programmed controller in vitro; and the stimulation system achieves a satisfying effect when applied to such fields as uracratia, urinary retention, Parkinson, spinal neuralgia, peripheral electrical stimulation therapy and the like.

Description

A kind of sacral nerve stimulation system
Technical field
The present invention relates to medical instruments field, particularly a kind of sacral nerve stimulation system.
Background technology
For the patient of spinal cord injury, often there is the phenomenon of the reflection of detrusor of bladder height and detrusor sphincter dyssynergia, cause urine retention and renal damage, mostly adopted Drug therapy in the past, interrupted catheterization treatment and various operative treatment etc., but it is undesirable to there is effect, treatment cycle is long, the shortcomings such as complication is many, until the appearance of sacral nerve roots stimulator, it is based on the detrusor principle different with sphincter biological characteristics, when adopting discontinuous pulses to stimulate, can because urinating appears in the intravesical pressure of lasting rising between twice stimulation period, but this mode of urinating belongs to one and manually to urinate pattern, stimulus parameter can not adjust by suitable carrying out, intravesical pressure is very high sometimes causes injury of kidney, secondly before sacral nerves, root comprises the nerve fiber of some domination lower limb, the shake of lower limb can be there is when stimulating, the use of inconvenient patient, before using early stage sacral nerves during root stimulating system, sacral posterior rhizotomy must be carried out, the height can eliminating detrusor like this opens reflection, but do like this and also can produce some problems, such as: lose defecation reflex and erection reflex, for some male patients, such cost is unacceptable.
Rijkhoff in 1991 etc. propose anode block technique, the conduction of the nerve that suppression diameter is large can be selected by this technology, realize minor diameter neural excited separately, this technology is applied in the process of root electricity irritation before sacral nerves by we, thus makes pattern physiological more of urinating.Before application anode block technique carries out electricity irritation sacral nerves, the method for root not only can be used for improvement and urinates, easy to use, also defecation may be improved in the future, make sacral nerve root stimulation technology be more suitable for the patient of incomplete injury of spinal cord, eliminate pain problem during incomplete injury of spinal cord patient electricity irritation.In addition, do not need to carry out sacral posterior rhizotomy by this kind of method treatment spastic bladder and will become possibility yet.
The frequency range that general sacral nerve stimulation system adopts differs, and the situation of interference and non-effective control usually can occur; The layout of outer body and implant part is indefinite; There is invalid problem in communication therebetween.
Summary of the invention
In view of this, the object of the invention is to propose a kind of sacral nerve stimulation system, utilize intervention means that a kind of stimulating current of short pulse is put on specific sacral nerves continuously, the electrophysiological characteristics of neurocyte itself is deprived with this, to activate excited artificially or to suppress nervous pathway, the sacral nerves reflex arc that interference is abnormal, and then the behavior of effector organ that impact is arranged with the sacral nerves such as at the bottom of adjustment bladder, sphincter of urethra and basin, play the effect of neuroregulation, treatment lower urinary tract and pelvic floor dysfunction disease.
Based on above-mentioned purpose a kind of sacral nerve stimulation system provided by the invention, comprise embedded nerve stimulator, stimulator program control instrument and stimulating electrode, wherein,
Described embedded nerve stimulator comprises MCU control module, special chip, protection circuit module, power management module and radio-frequency communication module, wherein,
Described MCU control module is connected respectively with described special chip and radio-frequency communication module, the signal received is carried out treatment and analysis, control signal is exported to special chip from radio-frequency communication module;
Described special chip is connected respectively with MCU control module and described stimulating electrode, after receiving control signal, selects stimulation channels, produces boost pulse and exports to stimulating electrode;
Described protection circuit module is connected with described special chip, carries out overvoltage protection to the output of special chip, electrostatic protection and electromagnetic interference noise reduction;
Described power management module at least comprises high capacity cell, is connected respectively with described MCU control module, special chip and radio-frequency communication module, is its power supply;
Described radio-frequency communication module is connected with described MCU control module, receives command signal from described stimulator program control instrument, carries out denoising and after amplifying, exports to described MCU control module;
Described stimulator program control instrument comprises ARM control module, USB communication module, charging module, medical implantable device-specific communication module, memory module, display module and key-press module, wherein,
Described ARM control module is connected respectively with USB communication module, charging module, medical implantable device-specific communication module, memory module, display module and key-press module, controls or input and output each module;
Described USB communication module is connected with computer, realizes computer to the debugging of stimulator program control instrument and test;
Described charging module is connected respectively with ARM control module and USB communication module, obtains the electric energy of external equipment or power supply, after charging, power to ARM control module from USB communication module;
Described medical implantable device-specific communication module is connected with described embedded nerve stimulator communication, and used is medical implantable device-specific frequency range;
Tell memory module the control signal of ARM control module, processing procedure and Received signal strength stored;
Described display module is connected with the output of ARM control module, stimulus parameter, state and electricity is shown;
Described key-press module is connected with the input of ARM control module, for switching stimulus parameter by pressing different key;
Described stimulating electrode is connected with described special chip, after receiving boost pulse, directly stimulates sacral nerves.
Preferably, also comprise system program control instrument, be connected with the communication of described stimulator program control instrument, debugging is carried out to stimulator program control instrument and directly parameter and state setting is carried out to embedded nerve stimulator.
Preferably, also comprise test stimulator, be connected with described embedded nerve stimulator communication, for testing parameter and the state of described embedded nerve stimulator after the implantation.
Preferably, the amplitude of described boost pulse is not more than 12V, and frequency is not more than 115Hz.
Preferably, the precision of described boost pulse is 50mV.
Preferably, described power management module also comprises rechargeable battery, has stimulator program control instrument to carry out wireless charging to it.
Preferably, described embedded nerve stimulator and described stimulator program control instrument can also carry out near-field communication by integrated circuit card.
Preferably, described stimulator program control instrument also comprises electrostatic protection module, is connected with ARM control module, carries out electrostatic defending to whole stimulator program control instrument.
Preferably, described stimulator program control instrument also comprises Power Management Unit, is connected with described charging module, carries out charging monitoring, control, overvoltage protection and overcurrent protection to it.
Preferably, described stimulator program control instrument also comprises bluetooth communication module, is connected with described ARM control module, carries out communication and exchanges data for making stimulator program control instrument and system program control instrument.
As can be seen from above, sacral nerve stimulation system provided by the invention, is made up of the nerve stimulator of implant into body and stimulator program control instrument thereof.Embedded nerve stimulator, by producing the electric pulse continued, can carry out electricity irritation at multiple position to target nerve; Patient can control embedded nerve stimulator by hand-held stimulator program control instrument in vitro.Sacral nerve stimulation system of the present invention has gratifying achievement in the application in the fields such as urinary incontinence, urine retention, parkinson, spinal nerves pain, Peripheral electrical stimulation treatment.
Accompanying drawing explanation
Fig. 1 is the entire block diagram of embodiment of the present invention sacral nerve stimulation system;
Fig. 2 is the structural representation of the embedded nerve stimulator of embodiment of the present invention sacral nerve stimulation system;
Fig. 3 is the structural representation of embodiment of the present invention stimulator program control instrument.
Detailed description of the invention
For making the object, technical solutions and advantages of the present invention clearly understand, below in conjunction with specific embodiment, and with reference to accompanying drawing, the present invention is described in more detail.
Consulting shown in Fig. 1-3, is the structural representation of the entire block diagram of embodiment of the present invention sacral nerve stimulation system, embedded nerve stimulator and stimulator program control instrument.Sacral nerve stimulation system comprises: embedded nerve stimulator 10, stimulator program control instrument 20 and stimulating electrode 30, wherein,
Described embedded nerve stimulator comprises MCU control module 101, special chip 102, protection circuit module 103, power management module 104 and radio-frequency communication module 105, wherein,
Described MCU control module 101 is connected respectively with described special chip 102 and radio-frequency communication module 105, the signal received is carried out treatment and analysis, control signal is exported to special chip 102 from radio-frequency communication module 105;
Described special chip 102 is connected respectively with MCU control module 101 and described stimulating electrode 30, after receiving control signal, selects stimulation channels, produces boost pulse and exports to stimulating electrode 30;
Described protection circuit module 103 is connected with described special chip 102, carries out overvoltage protection to the output of special chip 102, electrostatic protection and electromagnetic interference noise reduction;
Described power management module 104 at least comprises high capacity cell, is connected respectively with described MCU control module 101, special chip 102 and radio-frequency communication module 105, is its power supply;
Described radio-frequency communication module 105 is connected with described MCU control module 101, receives command signal from described stimulator program control instrument 20, carries out denoising and after amplifying, exports to described MCU control module 101;
Described stimulator program control instrument 20 comprises ARM control module 201, USB communication module 202, charging module 203, medical implantable device-specific communication module 204, memory module 205, display module 206 and key-press module 207, wherein,
Described ARM control module 201 is connected respectively with USB communication module 202, charging module 203, medical implantable device-specific communication module 204, memory module 205, display module 206 and key-press module 207, controls or input and output each module;
Described USB communication module 202 is connected with computer, realizes computer to the debugging of stimulator program control instrument 20 and test;
Described charging module 204 is connected respectively with ARM control module 201 and USB communication module 202, obtains the electric energy of external equipment or power supply from USB communication module 202, after charging, powers to ARM control module 201;
Described medical implantable device-specific communication module 204 is connected with the communication of described embedded nerve stimulator 10, and used is medical implantable device-specific frequency range;
Tell the control signal of memory module 205 pairs of ARM control modules 201, processing procedure and Received signal strength and store;
Described display module 206 is connected with the output of ARM control module 201, stimulus parameter, state and electricity is shown;
Described key-press module 207 is connected with the input of ARM control module 201, for switching stimulus parameter by pressing different key; Stimulus parameter comprises stimulus frequency, stimulates amplitude, boost pulse width, stimulation time and boost pulse dutycycle etc.;
Described stimulating electrode 30 is connected with described special chip 102, after receiving boost pulse, directly stimulates sacral nerves.
Further, also comprise system program control instrument, be connected with the communication of described stimulator program control instrument 20, debugging is carried out to stimulator program control instrument 20 and directly parameter and state setting is carried out to embedded nerve stimulator 10.
Further, also comprise test stimulator, be connected with the communication of described embedded nerve stimulator 10, for testing parameter and the state of described embedded nerve stimulator 10 after the implantation.
Further, the amplitude of described boost pulse is not more than 12V, and frequency is not more than 115Hz.
Further, the precision of described boost pulse is 50mV, and this precision have passed through to be improved heap of times and test, and realizes the ground nerve stimulation of super low-power consumption superhigh precision.
Further, described power management module 104 also comprises rechargeable battery, has stimulator program control instrument 20 to carry out wireless charging to it, uses rechargeable battery that lifetime of system can be made to extend to 20 years.
Further, described embedded nerve stimulator 10 and described stimulator program control instrument 20 can also carry out near-field communication by integrated circuit card, ensure that communication quality, and this is at present not available for other sacral nerve stimulation systems.
Further; described stimulator program control instrument 20 also comprises electrostatic protection module; be connected with ARM control module 201, electrostatic defending is carried out to whole stimulator program control instrument 20, if otherwise so accurate stimulation system exists electrostatic may puncture some key components or cause electric leakage.
Further, described stimulator program control instrument 20 also comprises Power Management Unit, is connected with described charging module 203, carries out charging monitoring, control, overvoltage protection and overcurrent protection to it.
Further, described stimulator program control instrument 20 also comprises bluetooth communication module, is connected with described ARM control module 201, carries out communication and exchanges data for making stimulator program control instrument 20 and system program control instrument.
Those of ordinary skill in the field are to be understood that: the foregoing is only specific embodiments of the invention; be not limited to the present invention; within the spirit and principles in the present invention all, any amendment made, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. a sacral nerve stimulation system, is characterized in that, comprises embedded nerve stimulator, stimulator program control instrument and stimulating electrode, wherein,
Described embedded nerve stimulator comprises MCU control module, special chip, protection circuit module, power management module and radio-frequency communication module, wherein,
Described MCU control module is connected respectively with described special chip and radio-frequency communication module, the signal received is carried out treatment and analysis, control signal is exported to special chip from radio-frequency communication module;
Described special chip is connected respectively with MCU control module and described stimulating electrode, after receiving control signal, selects stimulation channels, produces boost pulse and exports to stimulating electrode;
Described protection circuit module is connected with described special chip, carries out overvoltage protection to the output of special chip, electrostatic protection and electromagnetic interference noise reduction;
Described power management module at least comprises high capacity cell, is connected respectively with described MCU control module, special chip and radio-frequency communication module, is its power supply;
Described radio-frequency communication module is connected with described MCU control module, receives command signal from described stimulator program control instrument, carries out denoising and after amplifying, exports to described MCU control module;
Described stimulator program control instrument comprises ARM control module, USB communication module, charging module, medical implantable device-specific communication module, memory module, display module and key-press module, wherein,
Described ARM control module is connected respectively with USB communication module, charging module, medical implantable device-specific communication module, memory module, display module and key-press module, controls or input and output each module;
Described USB communication module is connected with computer, realizes computer to the debugging of stimulator program control instrument and test;
Described charging module is connected respectively with ARM control module and USB communication module, obtains the electric energy of external equipment or power supply, after charging, power to ARM control module from USB communication module;
Described medical implantable device-specific communication module is connected with described embedded nerve stimulator communication, and used is medical implantable device-specific frequency range;
Tell memory module the control signal of ARM control module, processing procedure and Received signal strength stored;
Described display module is connected with the output of ARM control module, stimulus parameter, state and electricity is shown;
Described key-press module is connected with the input of ARM control module, for switching stimulus parameter by pressing different key;
Described stimulating electrode is connected with described special chip, after receiving boost pulse, directly stimulates sacral nerves.
2. system according to claim 1, is characterized in that, also comprises system program control instrument, is connected with the communication of described stimulator program control instrument, carries out debugging and directly carry out parameter and state setting to embedded nerve stimulator to stimulator program control instrument.
3. system according to claim 1, is characterized in that, also comprises test stimulator, is connected with described embedded nerve stimulator communication, for testing parameter and the state of described embedded nerve stimulator after the implantation.
4. system according to claim 1, is characterized in that, the amplitude of described boost pulse is not more than 12V, and frequency is not more than 115Hz.
5. system according to claim 1, is characterized in that, the precision of described boost pulse is 50mV.
6. system according to claim 1, is characterized in that, described power management module also comprises rechargeable battery, has stimulator program control instrument to carry out wireless charging to it.
7. system according to claim 1, is characterized in that, described embedded nerve stimulator and described stimulator program control instrument can also carry out near-field communication by integrated circuit card.
8. system according to claim 1, is characterized in that, described stimulator program control instrument also comprises electrostatic protection module, is connected with ARM control module, carries out electrostatic defending to whole stimulator program control instrument.
9. system according to claim 1, is characterized in that, described stimulator program control instrument also comprises Power Management Unit, is connected with described charging module, carries out charging monitoring, control, overvoltage protection and overcurrent protection to it.
10. system according to claim 2, is characterized in that, described stimulator program control instrument also comprises bluetooth communication module, is connected with described ARM control module, carries out communication and exchanges data for making stimulator program control instrument and system program control instrument.
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CN110075422A (en) * 2019-06-12 2019-08-02 四川新源生物电子科技有限公司 The stimulator for having real time protection
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CN111167012A (en) * 2020-01-06 2020-05-19 哈尔滨理工大学 Implantable neural stimulator system based on radio frequency energy power supply
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CN105640537A (en) * 2016-03-30 2016-06-08 中国医学科学院生物医学工程研究所 Portable spinal cord monitoring system based on wireless transmission technology
CN106512214A (en) * 2016-12-20 2017-03-22 北京品驰医疗设备有限公司 Implantable sacral nerve stimulator adopting wireless percutaneous charging mode
CN106512216A (en) * 2016-12-20 2017-03-22 北京品驰医疗设备有限公司 Sacral nerve stimulation device having wireless charging device
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CN107261323A (en) * 2017-07-07 2017-10-20 北京品驰医疗设备有限公司 A kind of implanted is without wire sacral nerve stimulator
CN107998505A (en) * 2017-12-27 2018-05-08 苏鹏霄 A kind of wireless charging sacral nerve neuromodulation device
CN110075422A (en) * 2019-06-12 2019-08-02 四川新源生物电子科技有限公司 The stimulator for having real time protection
CN110327548A (en) * 2019-08-08 2019-10-15 吉林大学 A kind of Sacral nerve electrical stimulation system
CN111167012A (en) * 2020-01-06 2020-05-19 哈尔滨理工大学 Implantable neural stimulator system based on radio frequency energy power supply
US11221929B1 (en) 2020-09-29 2022-01-11 Hailo Technologies Ltd. Data stream fault detection mechanism in an artificial neural network processor
US11263077B1 (en) 2020-09-29 2022-03-01 Hailo Technologies Ltd. Neural network intermediate results safety mechanism in an artificial neural network processor
US11237894B1 (en) 2020-09-29 2022-02-01 Hailo Technologies Ltd. Layer control unit instruction addressing safety mechanism in an artificial neural network processor
US11811421B2 (en) 2020-09-29 2023-11-07 Hailo Technologies Ltd. Weights safety mechanism in an artificial neural network processor
US11874900B2 (en) 2020-09-29 2024-01-16 Hailo Technologies Ltd. Cluster interlayer safety mechanism in an artificial neural network processor
WO2022218127A1 (en) * 2021-04-16 2022-10-20 北京领创医谷科技发展有限责任公司 Implantable neurostimulator
CN113457014A (en) * 2021-08-03 2021-10-01 苏州景昱医疗器械有限公司 External program controller and control circuit and program control system thereof
WO2023011491A1 (en) * 2021-08-03 2023-02-09 苏州景昱医疗器械有限公司 In-vitro program controller, and control circuit and program control system thereof

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