CN105126238B - A kind of heart situ perfusion system based on pressure signal gate - Google Patents
A kind of heart situ perfusion system based on pressure signal gate Download PDFInfo
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- CN105126238B CN105126238B CN201510364718.3A CN201510364718A CN105126238B CN 105126238 B CN105126238 B CN 105126238B CN 201510364718 A CN201510364718 A CN 201510364718A CN 105126238 B CN105126238 B CN 105126238B
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Abstract
The invention discloses a kind of heart situ perfusion systems based on pressure signal gate, belong to the field of medical instrument technology, and system includes perfusion conduit, pressure sensor, hydraulic pump and signal screening device；The end of perfusion two inner tubes of conduit straight part is separately connected hydraulic pump and pressure sensor by infusion connecting tube, the inner tube of endcapped and side opening is communicated with the pump discharge of hydraulic pump, open-ended inner tube is communicated with pressure sensor, the pressure signal that pressure sensor measures when can be by work sends signal screening device to, and signal screening device starts or stops signal to hydraulic pump sending after handling pressure signal to control infusion opportunity.The present invention can be realized cell factor/stem cell and be transfused for a long time, have both safety, easy to operate, the high feature of targeting improves the therapeutic effect of Ischemic heart failure.
Description
Technical field
The present invention relates to a kind of perfusion systems that administration is realized for ischemic heart disease, and in particular to a kind of heart is in situ
Perfusion system, belongs to the field of medical instrument technology.
Background technique
Ischemic heart disease is to seriously threaten the common disease of human health.Current conventional therapy offer limited effectiveness is done thin
Born of the same parents transplant, cell factor infusion of therapeutic ischemic heart disease shows huge potentiality, but needs to play therapeutic effect in situ,
The intake of periphery non-target tissue is avoided to utilize.
Traditional heart delivery mode includes intracoronary injection, the injection transplantation in intramyocardial injection, Epicardium
Be intravenously injected with.
● injection transplantation in subendocardiac muscle：Cardiac infarct sites, range are determined by internal membrane of heart Electrophysiological mapping, are led to
Crossing injection catheter has the characteristics that accurate positioning in infarction tissue surrounding injection stem cell, but operating process is complicated, time-consuming, skill
Art qualification requires height, and equipment is expensive, limits the application of this method.
● injection transplantation in Epicardium：Usually in the open chest surgeries such as bypass operation of coronary artery or prosthetic valve replacement
It carries out simultaneously, this method accurate positioning, convenient for quantization and late detection, but due to needing open chest surgery, accommodator is less.
● through vein transplantation：Stem cell transplantation most simply and easily method, but transplanted cells cell factor need by
Systemic circulation, most of to be arrested in lung and liver, only a small amount of cell can reach cardiac muscular tissue, so transplanting inefficiency；
Cell factor is then degraded and is absorbed by surrounding tissue and utilizes, and target tissue effective dose is low, easily initiation side effect.
● intracoronary injection transplanting：For most common injection transplantation technology, using percutaneous coronary intervention (pci)
Method, guided through guiding catheter and coronary guide wire, the coronary artery for closing selection be encapsulated by microtubular or microballoon, utilize pressure will
Stem cell, cell factor infusion, reduce and overflow；To avoid conduit or sacculus long-time indwelling from causing thrombus in coronary artery, with most fast
Speed complete infusion.
Intracoronary injection is most common in four kinds of methods, injection followed by Epicardium.Both methods has
One common feature, both requires a possibility that once completing to transplant in a short period of time, being administered continuously or transplant hardly
In the presence of.Under physiological condition, stem cell is by inflammatory mediator induction, chemotactic, along blood vessel gradually to the process phase of damaged myocardium migration
Than common transplantation method and physiology course have huge difference at present, thus may be that stem-cell therapy effect also reaches far away pre-
One of factor of phase.Disposable infusion cell factor because the continuous erosion of blood flow acts on, after intracoronary injection in cardiac muscle concentration compared with
It is low, the direct effect to heart is reduced, while large amount of cell factor enters body circulation with blood flow and absorbed by other non-target tissues,
There may be potential hazards.Direct injection avoids the side effects such as first pass effect and the low blood pressure of intravascular injection in cardiac muscle, deposits
The advantages that local drug concentration is high, targeting is good, but intramyocardial injection needs after opening operation chest, cytokine injections in part
Hold time of short duration, and be unevenly distributed, hemangioma is formed and the disadvantages of inflammatory reaction.
Summary of the invention
In view of this, can be realized the present invention provides a kind of heart situ perfusion system based on pressure signal gate
Cell factor/stem cell is transfused for a long time, has both safety, easy to operate, the high feature of targeting improves Ischemic heart failure
Therapeutic effect.
A kind of heart situ perfusion system based on pressure signal gate, including perfusion conduit, hydraulic pump, infusion connection
Pipe, pressure sensor and signal screening device；
Wherein, the perfusion conduit includes two inner tubes inside external coating and external coating, two inner tubes
Outer surface is coated completely by external coating, and monnolithic case is made of straight part and hook portion, and the hook portion is by arc
Shape section and straightway composition, segmental arc connect with straight part；Two inner tubes one of the straightway corresponding position is end envelope
It closes and side is open, another is distal opening, its opening of the inner tube of side opening runs through external coating, the straight part pair
The end for two inner tubes answered is open architecture；
The pressure sensor energy sensed pressure signal simultaneously gives pressure signal transmission to signal screening device；
The discriminator can judge diastole time-histories according to the pressure signal received, open hydraulic pump sending
With the control signal of pass, controls hydraulic pump and realize cyclical administration；
Its overall connection relationship is：Distinguished by infusion connecting tube the end of perfusion two inner tubes of conduit straight part
Hydraulic pump and pressure sensor are connected, the inner tube that endcapped and side are open is communicated with the pump discharge of hydraulic pump, distal opening
Inner tube communicated with pressure sensor, the pressure sensor and signal screening device are electrically connected, and pressure sensor can will work
When the pressure signal that measures send signal screening device to；The hydraulic pump and signal screening device are electrically connected, signal screening device pair
Command signal is started or stoped to hydraulic pump sending after the pressure signal processing received.
Further, the signal screening device detects at the decent one third for winning wave in a pressure wave unit again
When position, which corresponds to the diastole of heart, issues enabling signal to hydraulic pump；In the ascending branch of next pressure wave unit
Wave trough position before, the position correspond to the systole phase of heart, issue termination signal to hydraulic pump.
Further, when the hydraulic pump receives termination signal, 10 milliseconds of pumpbacks movement is executed.
Further, the external coating is vulcanized by polythene material and steel wire, and polythene material determines perfusion
Hardness, shape and the frictional force with endangium of conduit, steel wire form the skeleton of perfusion conduit, make perfusion catheter lumen will not
It collapses and has the anti-effect of fractureing.
Further, the perfusion conduit straight part is length 105-110cm, and the outer diameter of conduit is 5F-7F.
Further, the arc radius of the segmental arc of the perfusion conduit hook portion is 3-5mm, and the length of straightway is
8-12mm。
Further, the pressure sensor, signal screening device and hydraulic pump integration constitute a component, are convenient for medical care
Personnel carry out operation and maintenance.
Further, the material that said inner tube uses is polyethylene or polyvinyl chloride.
Working principle：In use, heart situ perfusion conduit of the invention to be placed into the corresponding portion of heart through femoral artery
, the side on the straightway of hook portion, which is open, corresponds to the position coronary artery Dou Kou, and open-ended inner tube passes through connection pressure biography
Sensor incudes the pressure of the position, and to signal screening device sending pressure signal；Pressure signal obtains after the processing of signal screening device
To diastole time-histories, signal screening device controls hydraulic pump by the rule starting of diastole time-histories, is open by side
Inner tube to heart convey liquid.
Beneficial effect：
1, the present invention flows mostly to physilogical characteristics coronarius in diastole using the blood flow of coronary artery Dou Kou, through outer
All arteries send delivery conduit to indwelling near the coronary artery Dou Kou of aortic root, and conduit does not enter in coronary artery, in heart
Stem cell, cell factor are transfused by hydraulic pump through delivery conduit by diastole, and the systole phase stops, and cell/liquid is with coronary blood flow
Into coronary artery.
2, the selective diastole startup function signal screening device control of hydraulic pump of the invention, can accurately control perfusion
Opportunity.The potential risk that heart situ perfusion approach avoids open chest surgery and intracoronary catheter operates repeatedly is (by leading
Pipe, steel wire, sacculus coup injury lumen of vessels cause acute coronary narrow or occlusion, coronary artery perforation and cardiac tamponade, fluoride-free flux are existing
As equal coronary artery lesions complication for seriously jeopardizing patient vitals), safety is higher, and implementation is more easy, can be realized for a long time
Perfusion.
3, the present invention executes 10 milliseconds of pumpback movement in each transfusion stop, avoid in liquid-transport pipe-line liquid by
In cell factor/stem cell that oozing out occurs in pressure inertia is sent out with artery blood flow whole body the phenomenon that, drug is reduced to patient
Side effect, while can effectively save treatment cost.
Detailed description of the invention
Fig. 1 is system theory of constitution schematic diagram of the invention.
Fig. 2 is the outline structural diagram that conduit is perfused in the present invention；
Fig. 3 is the structural schematic diagram of perfusion conduit straight part of the invention；
Fig. 4 is application principle figure of the straightway in endocardial of perfusion conduit hook portion of the invention；
Fig. 5 is pressure signal gating principles figure of the invention.
Wherein, 1- external coating, 2- distal opening, 3- inner tube I, the side 4- opening, 5- inner tube II, 6- straight part, 7-
Hook portion.
Specific embodiment
As shown in Fig. 1, the present invention provides a kind of heart situ perfusion systems based on pressure signal gate, including fill
Infuse conduit, infusion connecting tube, pressure sensor, hydraulic pump and signal screening device；
Wherein, the perfusion conduit includes the inner tube I 3 and inner tube II 5 inside external coating 1 and external coating, described interior
The outer surface of pipe I 3 and inner tube II 5 is coated completely by external coating 1, and as shown in Fig. 2, monnolithic case is by 6 He of straight part
Hook portion 7 forms, and the hook portion 7 is made of segmental arc and straightway, and segmental arc connects with straight part 6；Such as attached drawing 3
It is shown, the endcapped of the inner tube I 3 of the straightway corresponding position and have side opening 4, the distal opening of inner tube II 5, inner tube
I 3 side opening runs through external coating 1, and the end of the corresponding inner tube I 3 of the straight part and inner tube II 5 is open architecture；
The length of the perfusion conduit straight part is 110cm, and the outer diameter of conduit is 6F, and the circle of the segmental arc of conduit hook portion is perfused
Arc radius is 4mm, and the length of straightway is 10mm；The external coating 1 is vulcanized by polythene material and steel wire, poly- second
Alkene material determines hardness, shape and the frictional force with endangium of perfusion conduit, and steel wire forms the skeleton of perfusion conduit, makes
Perfusion catheter lumen will not collapse and have anti-fractureing effect, and the material of inner tube I 3 and inner tube II 5 is polytetrafluoroethylene (PTFE).
The pressure sensor energy sensed pressure signal simultaneously gives pressure signal transmission to signal screening device；
The signal screening device can judge diastole time-histories according to the pressure signal received, send out hydraulic pump
The control signal of on and off out, control hydraulic pump realize cyclical administration；
Its overall connection relationship is：The end of the perfusion conduit straight part inner tube I 3 and inner tube II 5 is connected by infusion
Adapter tube is separately connected hydraulic pump and pressure sensor, and inner tube I 3 is communicated with the pump discharge of infusion pump, inner tube II 5 and pressure sensor
It communicates, the pressure sensor and signal screening device are electrically connected, and the pressure signal that pressure sensor measures when can be by work passes
Give signal screening device；The hydraulic pump and signal screening device are electrically connected, signal screening device to the pressure signal received at
Command signal is started or stoped to hydraulic pump sending after reason.
Working principle：In use, as shown in Fig. 4, heart situ perfusion conduit of the invention is placed into through femoral artery
The corresponding site of heart, the side on the straightway of hook portion are open the corresponding position coronary artery Dou Kou, and open-ended inner tube is logical
The pressure sensor crossed in open end connection hydraulic pump incudes the pressure of the position, and to signal screening device sending pressure signal；
As shown in Fig. 5, the signal screening device detects position at the decent one third for winning wave in a pressure wave unit again
When, which corresponds to the diastole of heart, issues enabling signal to hydraulic pump；Before the ascending branch of next pressure wave unit
Wave trough position, which corresponds to the systole phase of heart, issues termination signal to hydraulic pump；Each hydraulic pump receives termination letter
Number when, execute 10 milliseconds of pumpback movement.
Signal screening device controls hydraulic pump by the rule starting of diastole time-histories, and the inner tube being open by side is centripetal
Dirty Dou Kou conveys liquid, guarantees that medical fluid can completely enter endocardial.
In conclusion the above is merely preferred embodiments of the present invention, being not intended to limit the scope of the present invention.
All within the spirits and principles of the present invention, any modification, equivalent replacement, improvement and so on should be included in of the invention
Within protection scope.
Claims (5)
1. it is a kind of based on pressure signal gate heart situ perfusion system, which is characterized in that including perfusion conduit, hydraulic pump,
Infusion connecting tube, pressure sensor and signal screening device；
Wherein, the perfusion conduit includes two inner tubes inside external coating and external coating, the appearance of two inner tubes
Face is coated completely by external coating, and monnolithic case is made of straight part and hook portion, and the hook portion is by segmental arc
It is formed with straightway, segmental arc connects with straight part；Two inner tubes one of the straightway corresponding position be endcapped and
Side opening, another is distal opening, its opening of the inner tube of side opening runs through external coating, and the straight part is corresponding
The end of two inner tubes is open architecture；
The pressure sensor energy sensed pressure signal simultaneously gives pressure signal transmission to signal screening device；
The discriminator can judge diastole time-histories according to the pressure signal received, issue on and off to hydraulic pump
Control signal, control hydraulic pump realize cyclical administration；
Its overall connection relationship is：The end of perfusion two inner tubes of conduit straight part is separately connected by infusion connecting tube
The inner tube of hydraulic pump and pressure sensor, endcapped and side opening is communicated with the pump discharge of hydraulic pump, open-ended interior
Pipe is communicated with pressure sensor, and the pressure sensor and signal screening device are electrically connected, and pressure sensor is surveyed when can be by work
The pressure signal obtained sends signal screening device to；The hydraulic pump and signal screening device are electrically connected, and signal screening device is to reception
To pressure signal processing after to hydraulic pump sending start or stop command signal；
When the signal screening device detects position at the decent one third for winning wave in a pressure wave unit again, the position
The diastole of corresponding heart issues enabling signal to hydraulic pump；Trough position before the ascending branch of next pressure wave unit
It sets, which corresponds to the systole phase of heart, issues termination signal to hydraulic pump；
When the hydraulic pump receives termination signal, 10 milliseconds of pumpbacks movement is executed.
2. the heart situ perfusion system as described in claim 1 based on pressure signal gate, which is characterized in that the outsourcing
Coating is vulcanized by polythene material and steel wire.
3. the heart situ perfusion system as described in claim 1 based on pressure signal gate, which is characterized in that the perfusion
Conduit straight part is length 105-110cm, and the outer diameter of conduit is 5F-7F.
4. the heart situ perfusion system as described in claim 1 based on pressure signal gate, which is characterized in that the perfusion
The arc radius of the segmental arc of conduit hook portion is 3-5mm, and the length of straightway is 8-12mm.
5. the heart situ perfusion system according to any one of claims 1-4 based on pressure signal gate, which is characterized in that
The pressure sensor, signal screening device and hydraulic pump integration constitute a component.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510364718.3A CN105126238B (en) | 2015-06-26 | 2015-06-26 | A kind of heart situ perfusion system based on pressure signal gate |
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| CN201510364718.3A CN105126238B (en) | 2015-06-26 | 2015-06-26 | A kind of heart situ perfusion system based on pressure signal gate |
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| CN105126238B true CN105126238B (en) | 2018-11-27 |
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| CN108245227B (en) * | 2018-01-25 | 2021-06-18 | 西安交通大学医学院第一附属医院 | Interventional therapy drug delivery device |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN205268806U (en) * | 2015-06-26 | 2016-06-01 | 中国人民解放军总医院 | Heart in situ perfusion system based on pressure signal gate |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2502499B1 (en) * | 1981-03-27 | 1987-01-23 | Farcot Jean Christian | APPARATUS FOR BLOOD RETROPERFUSION, IN PARTICULAR FOR THE TREATMENT OF INFARCTUS BY INJECTION OF ARTERIAL BLOOD INTO THE CORONARY SINUS |
| FR2577424B1 (en) * | 1985-02-20 | 1989-04-28 | Gilles Karcher | CORONARY PERFUSION PUMP |
| CA2684807A1 (en) * | 2007-04-05 | 2008-10-16 | Velomedix, Inc. | Automated therapy system and method |
| WO2015017714A2 (en) * | 2013-07-31 | 2015-02-05 | Cvdevices, Llc | Unitary body systems and devices and methods to use the same for retroperfusion |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN205268806U (en) * | 2015-06-26 | 2016-06-01 | 中国人民解放军总医院 | Heart in situ perfusion system based on pressure signal gate |
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