CN105126237B - A kind of double mode heart situ perfusion system - Google Patents
A kind of double mode heart situ perfusion system Download PDFInfo
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- CN105126237B CN105126237B CN201510363454.XA CN201510363454A CN105126237B CN 105126237 B CN105126237 B CN 105126237B CN 201510363454 A CN201510363454 A CN 201510363454A CN 105126237 B CN105126237 B CN 105126237B
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Abstract
The invention discloses a kind of double mode heart situ perfusion system, belong to the field of medical instrument technology.System includes perfusion conduit, infusion connecting tube, pressure sensor, hydraulic pump, physiograph and signal screening device；The end of perfusion conduit two inner tubes of straight part connects hydraulic pump and pressure sensor respectively by infusion connecting tube, the inner tube of endcapped and side opening is communicated with the pump discharge of hydraulic pump, open-ended inner tube is communicated with pressure sensor, and pressure sensor sends the pressure signal measured to signal screening device；Physiograph sends human ecg signal to signal screening device；Signal screening device, which sends hydraulic pump after handling electrocardiosignal or pressure signal, starts or stops signal to control infusion opportunity.The characteristics of present invention can realize that cell factor/stem cell is transfused for a long time, have security, easy to operate concurrently, and targeting is high, improves the therapeutic effect of Ischemic heart failure.
Description
Technical field
The present invention relates to a kind of perfusion system that administration is realized for ischemic heart disease, and in particular to a kind of double mode heart
Dirty situ perfusion system, belongs to the field of medical instrument technology.
Background technology
Ischemic heart disease is the common disease of serious threat human health.Current conventional therapy offer limited effectiveness, does thin
Born of the same parents transplant, cell factor infusion of therapeutic ischemic heart disease shows huge potentiality, but needs to play therapeutic effect in the original location,
The intake of periphery non-target tissue is avoided to utilize.
Traditional heart delivery mode includes intracoronary injection, through injection transplantation in intramyocardial injection, Epicardium
Be intravenously injected with.
● injection transplantation in subendocardiac muscle：Cardiac infarct sites, scope are determined by internal membrane of heart Electrophysiological mapping, led to
Injection catheter is crossed in infarction tissue surrounding injection stem cell, there is accurate positioning, but operating process is complicated, time-consuming, skill
Art qualification requires height, and equipment is expensive, limits the application of this method.
● injection transplantation in Epicardium：Usually in the open chest surgery such as bypass operation of coronary artery or prosthetic valve replacement
It is carried out at the same time, this method accurate positioning, easy to quantify and late detection, but due to needing open chest surgery, accommodator is less.
● through vein transplantation：Stem cell transplantation most simply and easily method, but transplanted cells cell factor need by
Systemic circulation, most of to be arrested in lung and liver, only a small amount of cell can reach cardiac muscular tissue, so transplanting inefficiency；
Cell factor is then degraded and is absorbed by surrounding tissue and utilized, and target tissue effective dose is low, easily triggers side effect.
● intracoronary injection is transplanted：For most common injection transplantation technology, using percutaneous coronary intervention (pci)
Method, guided through guiding catheter and coronary guide wire, the coronary artery for closing selection be encapsulated by microtubular or microballoon, utilize pressure will
Stem cell, cell factor infusion, reduce and overflow；To avoid conduit or sacculus long-time indwelling from causing thrombus in coronary artery, with most fast
Speed complete infusion.
Intracoronary injection is most common in four kinds of methods, secondly injection in Epicardium.Both approaches have
One it is common the characteristics of, both required once to complete to transplant in a short period of time, be administered continuously or the possibility transplanted hardly
In the presence of.With under physiological condition, stem cell is induced by inflammatory mediator, chemotactic, along blood vessel progressively to damaged myocardium migrate process phase
Than common transplantation method has huge difference with physiology course at present, thus is probably that stem-cell therapy effect also reaches far away pre-
One of factor of phase.Disposable infusion cell factor because the continuous erosion of blood flow acts on, after intracoronary injection in cardiac muscle concentration compared with
It is low, the direct effect to heart is reduced, while large amount of cell factor is absorbed with blood flow into body circulation by other non-target tissues,
There may be potential hazard.Direct injection avoids the side effects such as first pass effect and the low blood pressure of intravascular injection in cardiac muscle, deposits
Local drug concentration is high, targeting is good the advantages that, but intramyocardial injection is needed after opening operation chest, cytokine injections in part
Hold time of short duration, and the shortcomings of the formation of skewness, hemangioma and inflammatory reaction.
The content of the invention
In view of this, the present invention provides a kind of double mode heart situ perfusion system, can be gated by pressure signal
Realize that cell factor/stem cell is transfused for a long time with electrocardiosignal gate both of which, have security, easy to operate, targeting concurrently
The characteristics of high, improve the therapeutic effect of Ischemic heart failure.
A kind of double mode heart situ perfusion system, including perfusion conduit, infusion connecting tube, pressure sensor, hydraulic pump,
Physiograph and signal screening device；
Wherein, the perfusion conduit includes two inner tubes inside external coating and external coating, two inner tubes
Outer surface is coated completely by external coating, its monnolithic case is made of straight part and hook portion, and the hook portion is by arc
Shape section and straightway composition, segmental arc connect with straight part；Two inner tubes one of the straightway corresponding position are sealed for end
Close and side opening, another is distal opening, its opening of the inner tube of side opening runs through external coating, the straight part pair
The end for two inner tubes answered is open architecture；
The pressure sensor energy sensed pressure signal simultaneously gives pressure signal transmission to signal screening device；
The electrocardiosignal of the physiograph monitoring human body is simultaneously exported it to signal screening by way of electric signal
Device；
The discriminator can judge diastole time-histories according to the human ecg signal or pressure signal received,
The control signal of on and off, the property performance period administration of control hydraulic pump are sent to hydraulic pump；
Its integrated connection relation is：Distinguished by infusion connecting tube the end of perfusion conduit two inner tubes of straight part
Connect hydraulic pump and pressure sensor, the endcapped and inner tube of side opening is communicated with the pump discharge of hydraulic pump, distal opening
Inner tube communicated with pressure sensor, the pressure sensor and signal screening device are electrically connected, and pressure sensor will can work
When the pressure signal that measures send signal screening device to；The physiograph passes through the heart that is wrapped at human body wrist and ankle
Conductance connection collects the electrocardiosignal of human body, and physiograph and signal screening device are electrically connected, and physiograph is by the people of collection
Body-centered electric signal sends signal screening device to；The hydraulic pump is electrically connected with signal screening device, and signal screening device believes electrocardio
Number or pressure signal carry out handling backward hydraulic pump sending and start or stop signal.
Further, under pressure signal gating patterns, the signal screening device detects weight in a pressure wave unit
At the decent 1/3rd of rich ripple during position, the diastole of the position correspondence heart, enabling signal is sent to hydraulic pump；Under
Wave trough position before the ascending branch of one pressure wave unit, in the systole phase of the position correspondence heart, send hydraulic pump stopping
Signal.
Further, when the hydraulic pump receives termination signal, 10 milliseconds of pumpbacks action is performed.
Further, under electrocardiosignal gating patterns, when signal screening device detects the decent of T ripples in electrocardiogram
When, signal screening device sends enabling signal to hydraulic pump, and when detecting the peak value of R ripples, signal screening device is sent to hydraulic pump to stop
Stop signal；
Further, can be every one or the interruption infusion of several cardiac electrical cycles under electrocardiosignal gating patterns, can be with
The availability of liquid is improved, reduces transfusion speed.
Further, the external coating is formed by polythene material and steel wire vulcanization, and polythene material determines perfusion
Hardness, shape and the frictional force with endangium of conduit, steel wire form the skeleton of perfusion conduit, make perfusion catheter lumen will not
Collapse and have the anti-effect of fractureing.
Further, the perfusion conduit straight part for length 105-110cm, the outside diameter of conduit is 5F-7F.
Further, the arc radius of the segmental arc of the perfusion conduit hook portion is 3-5mm, and the length of straightway is
8-12mm。
Further, the material that said inner tube uses is polyethylene or polyvinyl chloride.
Further, the hydraulic pump, physiograph, pressure sensor and signal screening device, which are integrated, forms a group
Part, operation and maintenance is carried out easy to medical staff.
Operation principle：In use, the heart situ perfusion conduit of the present invention is placed into the corresponding portion of heart through femoral artery
, the side opening on the straightway of hook portion corresponds to coronary artery Dou Kou positions, and doctor according to circumstances selects pressure signal to gate
With electrocardiosignal gating patterns.
Under pressure signal gating patterns, open-ended inner tube senses the artery of the position by connecting pressure sensor
Pressure, and to signal screening device sending pressure signal；Pressure signal obtains diastole time-histories after the processing of signal screening device,
Signal screening device control hydraulic pump is started by the rule of diastole time-histories, and liquid is conveyed to heart by the inner tube of side opening
Body.
Under electrocardiosignal gating patterns, electrocardiosignal obtains diastole time-histories after the processing of signal screening device, believes
Number discriminator control hydraulic pump is started by the rule of diastole time-histories, and liquid is conveyed to heart by the inner tube of side opening
Body.
Beneficial effect：
1st, the present invention flows mostly to physilogical characteristics coronarius using the blood flow of coronary artery Dou Kou in diastole, through outer
All arteries send delivery conduit to indwelling near the coronary artery Dou Kou of aortic root, and conduit does not enter in coronary artery, in heart
Stem cell, cell factor are transfused by diastole by hydraulic pump through delivery conduit, and the systole phase stops, and cell/liquid is with coronary blood flow
Into coronary artery.
2nd, the selective diastole startup function of hydraulic pump of the invention is controlled by physiograph and discriminator block, Neng Gouzhun
True control perfusion opportunity.Heart situ perfusion approach avoids the latent of open chest surgery and intracoronary catheter operation repeatedly
(cause acute coronary narrow in risk by conduit, steel wire, sacculus coup injury lumen of vessels or inaccessible, coronary artery is perforated and heart pressure
Plug, No-reflow phenoment etc. seriously jeopardize the coronary artery lesions complication of patient vitals), security higher, implementation is more easy, can
Realize and irrigate for a long time.
3rd, the present invention possesses pressure signal gate and electrocardiosignal gate both of which carries out the selection of infusion control, enriches
Operational means, is conducive to doctor and is operated selection according to the actual conditions of patient.
4th, the present invention performs 10 milliseconds of pumpbacks action under pressure signal gating patterns, during each transfusion stop, keeps away
Liquid is exempted from liquid-transport pipe-line since cell factor/stem cell that oozing out occurs in pressure inertia shows with what artery blood flow whole body was sent out
As reducing side effect of the medicine to patient, while can effectively save treatment cost.
Brief description of the drawings
Fig. 1 is the system theory of constitution schematic diagram of the present invention.
Fig. 2 is the outline structural diagram of the perfusion conduit of invention；
Fig. 3 is the structure diagram of the perfusion conduit straight part of invention；
Fig. 4 is position view of the straightway in endocardial of the perfusion conduit hook portion of the present invention；
Fig. 5 is the electrocardiosignal gating patterns schematic diagram of the present invention；
Fig. 6 is the electrocardiosignal gating patterns schematic diagram of the present invention (one, interval cardiac electrical cycle starts)；
Fig. 7 is the pressure signal gating patterns schematic diagram of the present invention.
Wherein, 1- external coatings, 2- distal openings, 3- inner tubes I, 4- sides opening, 5- inner tubes II, 6- straight parts, 7-
Hook portion.
Embodiment
As shown in Figure 1, the present invention provides a kind of double mode heart situ perfusion system, including perfusion conduit, infusion
Connecting tube, pressure sensor, hydraulic pump, physiograph and signal screening device；
Wherein, the perfusion conduit includes the inner tube I 3 and inner tube II 5 inside external coating 1 and external coating, described interior
The outer surface of pipe I 3 and inner tube II 5 is coated completely by external coating 1, and as shown in Figure 2, its monnolithic case is by 6 He of straight part
Hook portion 7 forms, and the hook portion 7 is made of segmental arc and straightway, and segmental arc connects with straight part 6；Such as attached drawing 3
It is shown, the endcapped of the inner tube I 3 of the straightway corresponding position and there is side opening 4, the distal opening of inner tube II 5, inner tube
I 3 side opening runs through external coating 1, and the end of the corresponding inner tube I 3 of the straight part and inner tube II 5 is open architecture；
The length of the perfusion conduit straight part is 110cm, and the outside diameter of conduit is 6F, irrigates the circle of the segmental arc of conduit hook portion
Arc radius is 4mm, and the length of straightway is 10mm；The external coating 1 is formed by polythene material and steel wire vulcanization, poly- second
Alkene material determines hardness, shape and the frictional force with endangium of perfusion conduit, and steel wire forms the skeleton of perfusion conduit, makes
Perfusion catheter lumen will not collapse and have the anti-effect of fractureing, and the material of inner tube is polytetrafluoroethylene (PTFE).
The end of the perfusion conduit straight part inner tube I 3 and inner tube II 5 connects hydraulic pump respectively by infusion connecting tube
And pressure sensor, inner tube I 3 are communicated with the pump discharge of infusion pump, inner tube II 5 is communicated with pressure sensor, the pressure sensing
Device is electrically connected with signal screening device, and pressure sensor can send the pressure signal measured when working to signal screening device；Institute
Physiograph is stated by the cardiac diagnosis lead that is connected at the wrist and ankle of human body, records the electrocardiosignal of human body, physiology note
Record instrument to be electrically connected with signal screening device, send the human ecg signal of collection to signal screening device；The hydraulic pump and letter
The electrical connection of number discriminator, signal screening device send hydraulic pump after handling electrocardiosignal or pressure signal startup or stop
Stop signal.
Operation principle：In use, the heart situ perfusion conduit of the present invention is placed into the corresponding portion of heart through femoral artery
Position, as shown in Figure 4, the side opening on the straightway of hook portion corresponds to coronary artery Dou Kou positions, and doctor according to circumstances selects
Pressure signal gates and electrocardiosignal gating patterns.
As shown in Figure 5, under electrocardiosignal gating patterns, when signal screening device detects the decline of T ripples in electrocardiogram
Zhi Shi, signal screening device send enabling signal to hydraulic pump, and when detecting the peak value of R ripples, signal screening device is sent to hydraulic pump
Stop signal；Pressure signal obtains diastole time-histories after the processing of signal screening device, and signal screening device control hydraulic pump is pressed
The rule of diastole time-histories starts, and liquid is conveyed to heart by the side opening of inner tube I 3.
As shown in Figure 6, can be every one or the interruption infusion of several cardiac electrical cycles under electrocardiosignal gating patterns, can
To improve the availability of liquid, transfusion speed is reduced.
As shown in Figure 7, under pressure signal gating patterns, open-ended inner tube is sensed by connecting pressure sensor
The pressure of the position, and to signal screening device sending pressure signal；The signal screening device is detected in a pressure wave unit
When winning position at the decent 1/3rd of ripple again, the diastole of the position correspondence heart, enabling signal is sent to hydraulic pump；
Wave trough position before the ascending branch of next pressure wave unit, in the systole phase of the position correspondence heart, sends hydraulic pump and stops
Stop signal.Pressure signal obtains diastole time-histories after the processing of signal screening device, and signal screening device control hydraulic pump presses the heart
The rule of dirty diastole time-histories starts, and liquid is conveyed to heart by the side opening of inner tube I 3.
In conclusion the foregoing is merely a prefered embodiment of the invention, it is not intended to limit the scope of the present invention.
Within the spirit and principles of the invention, any modification, equivalent replacement, improvement and so on, should be included in the present invention's
Within protection domain.
Claims (9)
1. a kind of double mode heart situ perfusion system, it is characterised in that including perfusion conduit, infusion connecting tube, pressure sensing
Device, hydraulic pump, physiograph and signal screening device；
Wherein, the perfusion conduit includes two inner tubes inside external coating and external coating, the appearance of two inner tubes
Face is coated completely by external coating, its monnolithic case is made of straight part and hook portion, and the hook portion is by segmental arc
Formed with straightway, segmental arc connects with straight part；Two inner tubes one of the straightway corresponding position for endcapped and
Side opening, another is distal opening, its opening of the inner tube of side opening runs through external coating, and the straight part is corresponding
The end of two inner tubes is open architecture；
The pressure sensor energy sensed pressure signal simultaneously gives pressure signal transmission to signal screening device；
The physiograph, which monitors the electrocardiosignal of human body and exports it by way of electric signal, gives signal screening device；
The discriminator can judge diastole time-histories according to the human ecg signal or pressure signal received, to liquid
Press pump sends the control signal of on and off, the property performance period administration of control hydraulic pump；
Its integrated connection relation is：The end of perfusion conduit two inner tubes of straight part is connected respectively by infusion connecting tube
Hydraulic pump and pressure sensor, endcapped and the inner tube of side opening are communicated with the pump discharge of hydraulic pump, open-ended interior
Pipe is communicated with pressure sensor, and the pressure sensor is electrically connected with signal screening device, and pressure sensor is surveyed when can be by work
The pressure signal obtained sends signal screening device to；Electrocardio of the physiograph also by being wrapped at human body wrist and ankle
Lead, collects the electrocardiosignal of human body, and physiograph is electrically connected with signal screening device, and physiograph is by the human body of collection
Electrocardiosignal sends signal screening device to；The hydraulic pump is electrically connected with signal screening device, and signal screening device is to electrocardiosignal
Or pressure signal carries out handling backward hydraulic pump sending and starts or stops signal.
2. double mode heart situ perfusion system as claimed in claim 1, it is characterised in that in pressure signal gating patterns
Under, when the signal screening device detects position at the decent 1/3rd for winning ripple in a pressure wave unit again, the position
The diastole of corresponding heart, enabling signal is sent to hydraulic pump；Trough position before the ascending branch of next pressure wave unit
Put, in the systole phase of the position correspondence heart, stop signal is sent to hydraulic pump.
3. double mode heart situ perfusion system as claimed in claim 2, it is characterised in that the hydraulic pump receives termination
During signal, 10 milliseconds of pumpbacks action is performed.
4. double mode heart situ perfusion system as claimed in claim 1, it is characterised in that in electrocardiosignal gating patterns
Under, when signal screening device detects the decent of T ripples in electrocardiogram, signal screening device sends enabling signal to hydraulic pump, inspection
When measuring the peak value of R ripples, signal screening device sends stop signal to hydraulic pump.
5. double mode heart situ perfusion system as claimed in claim 4, it is characterised in that under electrocardiosignal gating patterns
One, interval or the interruption infusion of several cardiac electrical cycles.
6. the double mode heart situ perfusion system as described in claim 1,2,3,4 or 5, it is characterised in that the outer cladding
Layer is formed by polythene material and steel wire vulcanization.
7. the double mode heart situ perfusion system as described in claim 1,2,3,4 or 5, it is characterised in that the perfusion is led
Pipe straight part for length 105-110cm, the outside diameter of conduit is 5F-7F.
8. the double mode heart situ perfusion system as described in claim 1,2,3,4 or 5, it is characterised in that the perfusion is led
The arc radius of the segmental arc of pipe hook portion is 3-5mm, and the length of straightway is 8-12mm.
9. the double mode heart situ perfusion system as described in claim 1,2,3,4 or 5, it is characterised in that the hydraulic pump,
Physiograph, pressure sensor and signal screening device, which are integrated, forms a component.
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| CN201510363454.XA CN105126237B (en) | 2015-06-26 | 2015-06-26 | A kind of double mode heart situ perfusion system |
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| CN201510363454.XA CN105126237B (en) | 2015-06-26 | 2015-06-26 | A kind of double mode heart situ perfusion system |
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| CN105126237B true CN105126237B (en) | 2018-04-24 |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108359604A (en) * | 2018-01-25 | 2018-08-03 | 山东百多安医疗器械有限公司 | A kind of conveying of stem cell seed and microenvironment regulating system |
| CN112138247A (en) * | 2020-06-04 | 2020-12-29 | 苏州润迈德医疗科技有限公司 | Gate-controlled radiography injection device and injection method |
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| US7819856B2 (en) * | 2004-10-05 | 2010-10-26 | Nexeon Medical Systems, Inc. | Methods and apparatus for treating infarcted regions of tissue following acute myocardial infarction |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4459977A (en) * | 1981-03-27 | 1984-07-17 | Veronique Pizon | Coronary sinus retroperfusion apparatus for the treatment of myocardial ischemia |
| US4804358A (en) * | 1985-02-20 | 1989-02-14 | Medicorp Research Laboratories Corporation | Coronary perfusion pump |
| EP0230996A2 (en) * | 1986-01-31 | 1987-08-05 | Mohl, Werner, M.D. | Pressure-Controlled Intermittent Coronary Sinus Occlusion |
| CN2208935Y (en) * | 1994-11-02 | 1995-10-04 | 李鸿德 | Intelligent transfusion pump |
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