CN104800902B - Extracorporeal circulation life supporting device for treating and curing multiple organ failure - Google Patents
Extracorporeal circulation life supporting device for treating and curing multiple organ failure Download PDFInfo
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- CN104800902B CN104800902B CN201510218620.7A CN201510218620A CN104800902B CN 104800902 B CN104800902 B CN 104800902B CN 201510218620 A CN201510218620 A CN 201510218620A CN 104800902 B CN104800902 B CN 104800902B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
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Abstract
The invention discloses an extracorporeal circulation life supporting device used for treating and curing multiple organ failure. The extracorporeal circulation life supporting device comprises an extracorporeal circulation pipeline which is connected between a vein or artery outlet end of a patient and a vein blood inlet end of the patient; a heparin pump, a first blood pump and a second blood pump are arranged on the extracorporeal circulation pipeline in turn; the extracorporeal circulation pipeline is branched into a first branch and a second branch between the first blood pump and the second blood pump; an oxygen combiner is arranged on the first branch; the second branch extends from the second blood pump which is provided with a blood clamp, a plasma separator, an active carbon jar and a resin jar are arranged at the lower edge of the second blood pump; the plasma outputted from a side wall of the plasma separator enters into the active carbon jar and the resin jar and enters into a blood filter together with the blood cells outputted from an outlet end of the plasma separator; the blood is purified and is applied to a supporting device for curing renal failure; all the branches are converged and enter into the body of the patient from the vein end. According to the extracorporeal circulation life supporting device, one device is used for independently or jointly supporting/replacing the heart, lung, liver and renal function failure.
Description
Technical field
The present invention relates to extracorporeal circulation life support technology field, more particularly, to one kind are used for giving treatment to multiple organ dysfunction syndrome
Extracorporeal circulation life support equipment.
Background technology
In medical domain, it is a kind of important Medical Technology that extracorporeal life is supported.
Extracorporeal life supports (Extracorporeal Life Support, abbreviation ELS) etymology in foreign literature, existing
Have in technology, clinical indication cardio-pulmonary function holding equipment is mainly ertro corporeal membrane oxygenation (Extracorporeal
Membrane oxygenation, abbreviation ECMO), other clinic organ failure's holding equipments, including respirator, Continuous Renal
Dirty replacement (Continuous renal replacement therapy, abbreviation CRRT) equipment and artificial liver etc..
The driving function first by the blood of ECMO for the ECMO, blood is drained into extracorporeal circulation from vivo, through synthetic membrane
After lung oxygen closes, then oxygenated blood is fed in vivo, to maintain the oxygen supply of each organ of body, can be to serious reversibility respiratory failure
Patient is supported for a long time with heart failure, so that Patients with Lung or cardiopulmonary is sufficiently rested, and is lung or cardio-pulmonary function
Recovery tries to gain time precious to one.Therefore, ECMO is mainly used in the recovery that postcardiac surgery maintains cardio-pulmonary function, is also used for other reversible
Property cardiopulmonary exhaustion (as caused by heart infarction, sudden death, pulmonary embolism etc. during cardiorespiratory failure), and adult respiratory distress syndrome
(ARDS).The maximum shortcoming of ECMO can not support hepatic and renal function
CRRT is main blood cleaning equipment, for the patient of renal failure, can replace completely in the regular period
For renal function.Domestic application CRRT in Urology Department and intensive care unit (ICU), treats and how dirty decline (heart kidney liver failure) and acute exhale
Inhale Distress syndrome (ARDS).
Artificial liver technology, refers to that plasmapheresiss and blood purification, adsorption technology combine, that is, there is septicemia element and be eliminated
External or be adsorbed onto on the carrier with abundant surface area to use and remove from blood, domestic artificial liver is helped in hepatopathy section or kidney section
Help implementation, Liver and kidney exhaustion simultaneously is completed by kidney section.
In medical clinical practice, in view of how dirty (the cardiopulmonary kidney liver) patient that declines in ICU, CCU (coronary heart disease Intensive Care Therapy)
Increase, but not a kind of individually multi-functional equipment of collection in prior art, can assist or substitute multiple organs failure
Function.
The extracorporeal circulation holding equipment such as above-mentioned ECMO, CRRT of prior art, is respectively provided with single internal organs and supports function,
Can the single Organ Failure of reply.
Between the said equipment, existing connected mode is external combination, and such as ECMO is combined with transfusion filterses, for the heart
Lung failure merges renal failure；And CRRT and ECMO combines, for treating kidney liver failure and cardiopulmonary exhaustion.In a word, at present
There is no both at home and abroad in this kind equipment in joint clinical practice.ECMO and CRRT was that two independent outside individuals join respectively in the past
Close, do not have inherent multiple function to concentrate on a machine.
In the ward of the limited area of ICU, CCU, in the face of the patient of various organ failures, and patient is over the course for the treatment of
It is likely to new other types of organ failure, therefore, the extracorporeal circulation holding equipment of existing simple function, in reply
Inconvenience is had during above-mentioned situation.Frequently the mobile connection with equipment room same control device of equipment, not only can stop over to patient
The time given treatment to, also due to be difficult the complex operation realizing being uniformly controlled and increase operator between distinct device
Degree.
To sum up, the extracorporeal circulation life support equipment of prior art exists and can not be uniformly controlled, and needs multiple equipment
The technical problem reconnecting, the present invention is that several functions concentrate on a machine, and is automatically controlled by computer and selectable many work(
Can treatment system.
Content of the invention
For problems of the prior art, the purpose of the present invention is supported for providing a kind of Multifunctional external cycle life
Equipment.
For reaching above-mentioned purpose, the broader embodiment of the present invention, for providing a kind of extracorporeal circulation life support equipment, is used for
Treatment multiple organ dysfunction syndrome, described extracorporeal circulation life support equipment be formed with the vein being connected to patient or tremulous pulse go out end with
The vein of patient enters the extracorporeal circulation pipeline between end, and described extracorporeal circulation pipeline is disposed with the first blood pump, the second blood
Pump, described extracorporeal circulation pipeline branches into the tie point that entrance may be selected and the between described first blood pump, the second blood pump
Two branch roads；Oxygenator is provided with described tie point, the vein described in blood flowing after oxygen closes enters end；On described second branch road
The downstream branch of described second blood pump is separation branch road and the filtration branch road that may be selected to enter, and described separation is provided with blood on branch road
Slurry separator, described filtration branch road is provided with transfusion filterses with the described meet separating branch road, described plasma separator with
Between described filtration branch road, there is blood plasma branch road；The blood cell that described plasma separator is isolated separates described blood plasma on branch road through described
The downstream of separator flows into described transfusion filterses, the blood plasma that described plasma separator is isolated successively through described blood plasma branch road and
Described filtration branch road flows to described transfusion filterses；The venous blood described in blood flowing of described transfusion filterses filtration enters end.
The extracorporeal circulation life support equipment of the present invention it is preferred that in described tie point the upstream of described oxygenator set
It is equipped with the first blood folder, the described upstream separating described plasma separator on branch road is provided with the second blood folder, described filtration branch road sets
It is equipped with the 3rd blood folder, the blood plasma of described blood plasma branch road flows to described transfusion filterses from the downstream of described 3rd blood folder.
The extracorporeal circulation life support equipment of the present invention it is preferred that described first blood pump is air driven pump, described first blood pump
Hemodynamic environment be 4 liters every point, described second blood pump is roll pump, and the Hemodynamic environment of described second blood pump is 0～500 milliliter every point.
The extracorporeal circulation life support equipment of the present invention it is preferred that the Hemodynamic environment of described first blood pump is 4 liters every point, institute
The Hemodynamic environment stating the second blood pump is every point of 150-500 milliliter.
The extracorporeal circulation life support equipment of the present invention is it is preferred that the Hemodynamic environment of described second blood pump is 400 milliliters every point
When, the Hemodynamic environment of described filtration branch road controls at 250 milliliters every point, and the Hemodynamic environment separating on branch road controls at 150 milliliters often
Point.
The extracorporeal circulation life support equipment of the present invention is it is preferred that be optionally provided with described blood plasma branch road：Resin
Tank and/or absorbent charcoal adsorption tank；Treatment sepsis, rheumatological disease, the adsorption tanks of poisoning.
The extracorporeal circulation life support equipment of the present invention, it is preferred that also including warmer, is arranged at following position at least
At one：The downstream of described first blood pump on main line；Described tie point；Described filtration branch road, the described branch road that separates converge
Between point and described venous inlet.
The extracorporeal circulation life support equipment of the present invention is it is preferred that described extracorporeal circulation life support equipment has a master
Cabinet, described mainframe box appearance is integrated with plasma separator, the panel of transfusion filterses, oxygenator and each described blood pump, with
It is uniformly controlled and automatically controls plasma separator, transfusion filterses, oxygenator and each described blood pump by computer program, described
Mainframe box desktop has the operation interface of function selecting, parameter setting, monitoring display and control selections.
The extracorporeal circulation life support equipment of the present invention is it is preferred that described oxygenator is membrane oxygenator；Described second blood
Between pump and described plasma separator, on blood plasma branch road, it is provided with pressure monitor；The upstream or described of described first blood pump
The downstream of the second blood pump is provided with heparin pump；On described filtered solution branch road, the downstream of described transfusion filterses is provided with vein pressure
Table and fluid balancing device.
The extracorporeal circulation life support equipment of the present invention is it is preferred that described plasma separator, transfusion filterses, oxygenator
Include controlling in described plasma separator, transfusion filterses, oxygenator and each described blood pump with the panel of each described blood pump
The panel of portion's circuit.
The beneficial effects of the present invention is, the extracorporeal circulation life support equipment of the present invention, is following in vitro of a tractor serves several purposes
Ring life support equipment.It is exactly to pass through an equipment, support/substitute the heart, lung, Liver and kidney function exhaustion alone or in combination.
The extracorporeal circulation life support equipment of the present invention, is not the development of ECMO function and widening of indication, is not
How dirty the external therapeutic alliance of ECMO and CRRT is declines.But in the function of ECMO and CRRT be combined into a machine, by unified
The procedural combination that computer controls, collect multi-functional in a machine, can select individually or multiple organ support simultaneously (as the heart, lung, liver,
The function of kidney is supported).The extracorporeal circulation life support equipment of the present invention, in addition to for the how dirty treatment declining, can also treat pus
Toxication, rheumatological disease, poisoning etc. (depending on selecting different adsorption tanks).
The extracorporeal circulation life support equipment of the present invention, when being arranged in ICU, CCU ward, can successfully manage various dirty
The patient of device exhaustion, even if patient occurs new other types of organ failure over the course for the treatment of, does not have frequently equipment
The mobile connection with equipment room same control device, will not stop over the time that patient is given treatment to, also will not be set due to difference
The operation complexity being uniformly controlled and increasing operator is not enabled between standby.
Brief description
Fig. 1 is the schematic diagram of the extracorporeal circulation life support equipment of the embodiment of the present invention.
Fig. 2 is that the extracorporeal circulation life support equipment of the embodiment of the present invention individually carries out the circulation road warp of cardio-pulmonary function support
Schematic diagram.
Fig. 3 is that the extracorporeal circulation life support equipment of the embodiment of the present invention carries out the circulation road of cardiopulmonary renal function support through showing
It is intended to.
Fig. 4 is that the extracorporeal circulation life support equipment of the embodiment of the present invention carries out the circulation road of cardiopulmonary liver function support through showing
It is intended to.
Fig. 5 is the circuit design diagram of the extracorporeal circulation life support equipment of the embodiment of the present invention.
Specific embodiment
Some the typical case's enforcement cases embodying feature of present invention with advantage will describe in the explanation of back segment in detail.It should be understood that
Be the present invention can have in different enforcement patterns various different control treatment functions, so its model all without departing from the present invention
Enclose, and explanation therein and accompanying drawing are illustrated as being used in itself, and be not used to limit the present invention.
The present invention is preferable to carry out the extracorporeal circulation life support equipment of case, as Figure 1-Figure 5, including vein or tremulous pulse
Outlet 100, venous inlet 700, and it is connected to the extracorporeal circulation set tube between vein or tremulous pulse outlet 100 and venous inlet 700
Road, the first blood pump 201 of setting, the second blood pump 801 and plasma separator 402, hemofiltration on circulation circulation line in vitro
Device 503 grade capital equipment.
As shown in figure 1, extracorporeal circulation circulation line includes main line 200, tie point 300, the second branch road 800, separates
Branch road 400, filtration branch road 500 and blood plasma branch road 450 etc..
Wherein, it is that whole blood is flowing in main line 200, be provided with heparin pump 202, it is of course also possible on the second branch road 800
The downstream setting heparin pump 804 of the second blood pump 801, in case hemostasis-coagulation.And blood plasma branch road 450 is plasma flow, and separate branch road
The downstream of plasma separator 402 on 400, then be blood cell flowing.
As shown in figure 1, in the downstream of the first blood pump 201, main line 200 branches into tie point 300 and the second branch road
800, the second blood pump 801 is arranged on the second branch road 800.Tie point 300 finally flows back to venous inlet 700, and the second branch road
800 branch into and separate branch road 400 and filtration branch road 500, are more also connected to venous inlet 700 after converging.And separate branch road 400
And filtration branch road 500 between, it is additionally provided with blood plasma branch road 450.
Oxygenator 301, the first blood folder 302 are provided with tie point 300, warmer 303 also can be set again.Wherein,
One blood folder 302 is arranged on the upstream of oxygenator 301；Upstream mentioned here, is with blood in pipeline or blood component flow
For direction, position that blood first flows through is upstream position, after the position that flows through be downstream position.And oxygenator 301, then excellent
Choosing is membrane oxygenator, namely membrane lung.
Separate and be provided with plasma separator 402 on branch road 400, plasma separator 402 has two-way to export, a road is to separation
The downstream output of plasma separator 402 on branch road 400, output is the blood cell that plasma separator 402 is isolated, another Lu Zetong
Cross blood plasma branch road 450, filtration branch road 500, flow to transfusion filterses 503, that is, allow blood cell and blood plasma all pass through hemofiltration
Device 503 is filtered.
Separate the upstream of plasma separator 402 on branch road 400, be provided with the second blood folder 401, filtration branch road 500 is provided with
3rd blood folder 501, if not needing blood plasma to separate and adsorbing therapy, cuts out the second blood folder 401, blood is from the second blood pump 801
Row is directly entered filtration branch road 500, in the case that the 3rd blood folder 501 is opened, enters transfusion filterses 503, through blood filter
Cross process, then through fluid balancing device 502 and vein pressure table 504, the blood of purification returns to patient's body from venous inlet 700
Interior.As shown in Figure 3.
As shown in figure 1, the extracorporeal circulation life support equipment of the embodiment of the present invention, in filtration branch road 500 and separation branch road
400 meet is connected with the support device for treating renal failure, namely transfusion filterses 503, the downstream of filtration branch road 500
Also it is connected to venous inlet 700.The extracorporeal circulation life support equipment of the embodiment of the present invention, can only have renal failure and support dress
Put, or have renal failure to support that device and liver failure support device simultaneously, but it is preferred that both there is liver failure support device,
There is renal failure again and support device.Wherein, renal failure supports that device is preferably Treated with High Volume Hemofiltration machine (HVHF) 503, and
Liver failure is supported to be serially connected charcoal canister 452 and the resin container 453 of setting on device preferably blood plasma branch road 450, namely
Artificial liver.
The extracorporeal circulation life support equipment of the embodiment of the present invention, can be also used for treating sepsis, rheumatological disease
Disease, poisoning etc..At this moment, can on blood plasma branch road 450 additional resin tank and various immunoadsorption tank, sepsis, wind can be treated
Wet immune disease, poisoning etc..
As shown in figure 1, the upstream of oxygenator 301 is provided with the first blood folder 302 in tie point 300, and blood cell side separates
Second blood folder 401 is provided with branch road 400, filtration branch road 500 is provided with the 3rd blood folder 501.First blood presss from both sides the 302, second blood
The effect of folder 401 and the 3rd blood folder 501 is to block or opens the branch road being each located so that the following in vitro of the embodiment of the present invention
Ring life support equipment has different circulation road warps, to tackle dissimilar and combination organ failure patient.Blood pump also can generation
For blood folder.
By the first blood is pressed from both sides with the control of the 302, second blood folder 401 and the 3rd blood folder 501, in conjunction with to the first blood pump 201
Control with the second blood pump 801, it is possible to achieve in vitro the different blood in circulation line or blood constituent flow through path,
To tackle dissimilar and combination organ failure patient.
Wherein, for the first blood pump 201 and the second blood pump 801, if blood pump drives function is opened, the first blood pump 201
There is provided power with the second blood pump 801 to extracorporeal circulation.
Wherein, the first blood pump 201 preferably air driven pump, the Hemodynamic environment of the first blood pump 201 is 4 liters every point, and it has no
Blood cell damages or blood cell damages light advantage, and the second blood pump 801 can be roll pump, and the Hemodynamic environment of the second blood pump 801 is 0～500
Every point of milliliter.Described extracorporeal circulation, when carrying out low discharge extraction, the Hemodynamic environment of the first blood pump 201 and the second blood pump 801 can be
200～400 milliliters every point.
Patient for cardiopulmonary renal failure or cardiopulmonary liver failure it is preferred that the Hemodynamic environment of the first blood pump 201 is 4 liters every point,
The Hemodynamic environment of the second blood pump 801 is 150～500 milliliters every point.Preferably, the second blood pump 801 controls the blood flow of the second branch road 800
Speed is 400 milliliters of every timesharing, and the Hemodynamic environment of filtration branch road 500 can be controlled in 250 milliliters every point, and separates the blood on branch road 400
Flow speed control, at 150 milliliters every point, can be controlled to this Hemodynamic environment by blood pump 456, as shown in Figure 5.
Describe the extracorporeal circulation circulating path to all types of organ failures individually below.
Firstly, for simple cardiopulmonary failure patients, the extracorporeal circulation life support equipment of the embodiment of the present invention, carrying out
When extracorporeal circulation life is supported, need to control the first blood pump 201 to open every point of flow velocity 4L, and control the second blood pump 801 to close, this
When, the circulation road of extracorporeal circulation pipeline is through as shown in Fig. 2 the blood flowing out from the tremulous pulse of patient is through main line 200, Jing Guo
The pumping of one blood pump 201, flows back to the venous inlet 700 of patient from tie point 300.When flowing through tie point 300, blood passes through
Oxygenator 301 plays Oxygenation, to provide extracorporeal circulation life to support cardiopulmonary failure patients.
And the patient for cardiopulmonary exhaustion merging liver, renal failure, then need to open the first blood pump 201 and the second blood pump simultaneously
801.The Hemodynamic environment that first blood pump 201 can control main line 200 is 4 liters every point, and the Hemodynamic environment that the second blood pump 801 controls is, for example,
400 milliliters every point, namely the blood of the first blood pump 201 output, most blood are by tie point 300 by oxygenator
The venous inlet 700 of 301 backflow patients.And the second blood pump 801 controls 400 milliliters every point of Hemodynamic environment, wherein part blood with 150
The Hemodynamic environment of every point of milliliter enters and separates branch road 400, enters plasma separator 402 and adsorption tanks 453,452.Open 3rd blood folder
501, make residual blood enter transfusion filterses 503 with 250 milliliters every point of Hemodynamic environment, carry out hemofiltration, discharge waste liquid, only
The blood changed finally enters venous inlet 700.
If patient does not have cardiopulmonary exhaustion, for example simple liver failure, then the first blood pump 201 (control Hemodynamic environment 200～300
Every point of milliliter) blood out is directly entered the plasma separator 402 separating branch road 400, and the blood plasma isolated enters blood plasma and props up
The adsorption tanks 453,452 (artificial liver) on road 450 carry out adsorbing therapy.If simple renal failure, then it is directly entered filtration
The transfusion filterses 503 on road 500 carry out Hemofiltration for Treatment.
For simple patients with renal failure, control the first blood pump 201, and the first blood folder of tie point to be closed 300
302 press from both sides 401 with the second blood separating on branch road 400, block tie point 300 and separate branch road 400, open the 3rd blood and press from both sides 501.
Now, blood is filtered through Treated with High Volume Hemofiltration device 503, to provide extracorporeal circulation life to support patients with renal failure,
Venous inlet 700 from transfusion filterses 503 blood flowing patient out.
For simple hepatic failure patients, the Hemodynamic environment adjusting the first blood pump 201 is every point of 200-300 milliliter, and will
Close the first blood folder 302, block tie point 300, open the second blood folder 401, make blood plasma pass through plasma separator 402, enter
Plasma separator 402 and immunoadsorption tank 453 and absorbent charcoal adsorption tank 452, enter venous inlet 700.Now, the 3rd blood folder
501 closings, but have no effect on the downstream of the blood plasma isolated in plasma separator 402 the 3rd blood folder 501 from filtration branch road 500
Flow into transfusion filterses 503.
Cardiopulmonary exhaustion is merged to the patient of renal failure, the extracorporeal circulation life support equipment of the embodiment of the present invention, entering
When row extracorporeal circulation life is supported, as shown in figure 3, needing to control the Hemodynamic environment of the first blood pump 201 to be every point of 4L, open the simultaneously
Two blood pumps 801,200 milliliters every point of its Hemodynamic environment, open first blood folder 302, blood enters tie point 300, enters membrane lung；Close
Close the second blood folder 401 separating branch road 400, open 3rd blood folder 501, make blood enter filtration branch road 500, by hemofiltration
Device 503.Now, the present invention implements circulation Lu Jingru Fig. 3 of the extracorporeal circulation pipeline of extracorporeal circulation life support equipment of case
Shown, the blood flowing out from the tremulous pulse of patient, through main line 200, through the pumping of the first blood pump 201, makes blood from first
Oxygenator 301 is simultaneously passed through in road 300.Open 3rd blood folder 501, blood enters filtration branch road 500, and passes through transfusion filterses 503
Carry out blood purification, then flow back to the venous inlet 700 of patient.When flowing through tie point 300, blood is through oxygenator 301
To Oxygenation；And when flowing through filtration branch road 500, carry out hemofiltration through Treated with High Volume Hemofiltration device 503, to decline to cardiopulmonary
The patient's offer extracorporeal circulation life support merging renal failure is provided.
Cardiopulmonary exhaustion is merged to the patient of liver failure, the extracorporeal circulation life support equipment of the embodiment of the present invention, entering
When row extracorporeal circulation life is supported, as shown in figure 4, needing to control 4 liters every point of the first blood pump 201 Hemodynamic environment, opening and controlling the
Two blood pumps 801,200 milliliters every point of its Hemodynamic environment, the first blood folder 302 unlatching, blood passes through membrane lung in tie point 300, the
Two blood folder 401 unlatching, closes the 3rd blood folder 501.Blood filtration branch road 400 on blood through plasma separator 402, blood plasma divides
From the side opening of device 402, namely the position that is connected with blood plasma branch road 450 of plasma separator 402 blood plasma out enters adsorption tanks
452nd, 453, through adsorption, through blood plasma branch road 450, filtration branch road 500, return in the patient from venous inlet 700.Logical
Cross plasma separator 402 blood cell out and enter transfusion filterses 503 through separating branch road 400, done according to clinical needs or not
Do blood purification, therefore, converge from the filtration blood plasma that comes of branch road 500 with from separating the blood cell that branch road 400 comes, whole blood passes through
Transfusion filterses 503 filter, and return internal after filtration.Now, the circulation road of extracorporeal circulation pipeline is through as shown in figure 4, from patient
The blood that flows out of vein through main line 200, through the pumping of the first blood pump 201, branch into tie point 300, enter film
Lung, and the blood of the second branch road 800, then enter and separate branch road 400, enters plasma separator 402, from plasma separator 402 side
Hole blood plasma out, enters transfusion filterses 503 after entering adsorption tanks 452,453；From plasma separator 402 side wall blood out
Ball enters and separates branch road 400, also into transfusion filterses 503.In a word, when flowing through tie point 300, blood is through oxygenator
301 play Oxygenation；And when flowing through blood plasma branch road 400, blood plasma through the absorption of resin container 453 and absorbent charcoal adsorption tank 452,
Extracorporeal circulation life is provided to support with the patient that cardiopulmonary exhaustion is merged with liver failure.
The extracorporeal circulation life support equipment of the embodiment of the present invention, in the specific implementation, its each branch road, pipeline design can
As shown in figure 5, being summarized as follows：
For main line 200, the first blood pump 201 is set thereon.The end of main line 200, is branched into by a threeway
Tie point 300 and the second branch road 800.
In tie point 300, setting oxygenator 301, warmer 303 and the first blood folder 302.
Second blood pump 801 and heparin pump 202 are provided with the second branch road 800.
Second branch road 800 branches into and separates branch road 400 and filtration branch road 500.
For separating branch road 400, being additionally provided with blood folder 401 and first between the second blood pump 801 and plasma separator 402 can
Control formula pressure monitor 403, to monitor the real-time pressure of the second branch road 800.On blood plasma branch road 450, pressure prison can be set
Survey device 455.
As shown in figure 5, before separating the converging of branch road 400 and tie point 300, in the downstream of transfusion filterses 503, can set
It is equipped with gas bubble detection 407.And tie point 300, the point separating branch road 400 and filtering branch road 500, with venous inlet
Between 700, filter 305 and warmer 306 can be set, the effect of warmer 306 is so that temperature and the human body temperature of blood
It coincide.
In addition, Treated with High Volume Hemofiltration device 503 downstream also can arrange liquid discrepancy bascule 502, to carry out fluid infusion.Only
The blood changed and the displacement liquid supplementing finally converge, then converge with tie point 300, enter vein and enter in 700 ex vivos of end.
In the waste liquid side of transfusion filterses 503, it is respectively arranged with blood pump 901, mixed-blood detector 902, claims 903 and waste liquid chamber
904；In the displacement liquid side of transfusion filterses 503, it is respectively arranged with warmer 905, blood pump 906, claims 907 and displacement sap cavity 908.
The extracorporeal circulation life support equipment of the embodiment of the present invention, is the extracorporeal circulation life support equipment of a tractor serves several purposes.
It is exactly to pass through an equipment, multi-functional support/replacement heart, lung, Liver and kidney function exhaustion alone or in combination.
The extracorporeal circulation life support equipment of the present invention, is not the development of ECMO function and widening of indication, is not
How dirty the external therapeutic alliance of ECMO and CRRT is declines.But in the function of ECMO and CRRT be combined into a machine, by same
The procedural combination that computer controls, be multi-functional in a machine, can select individually or multiple organ support simultaneously (as the heart, lung, liver,
The function of kidney is supported).The extracorporeal circulation life support equipment of the present invention, in addition to for the how dirty treatment declining, can also treat pus
Toxication, rheumatological disease, poisoning etc..
The extracorporeal circulation life support equipment of the embodiment of the present invention, has a mainframe box, and described mainframe box is integrated with blood plasma
The panel of separator 402, transfusion filterses 503, oxygenator 301 and each blood pump 201,801 etc., to be united by computer program
One controls and automatically controls plasma separator 402, transfusion filterses 503, oxygenator 302 and each blood pump 201,801, and mainframe box has
The operation interface of functional selection, parameter setting, monitoring display and control selections.And above-mentioned panel, including control blood plasma
Separator 402, the panel of the internal circuit of transfusion filterses 503, oxygenator 301 and each blood pump 201,801.
The extracorporeal circulation life support equipment of the present invention, when being arranged in ICU, CCU ward, can successfully manage various dirty
The patient of device exhaustion, even if patient occurs new other types of organ failure over the course for the treatment of, does not have frequently equipment
Mobile and equipment reconnects, and will not stop over the time that patient is given treatment to, also will not be due to can not be real between distinct device
Now it is uniformly controlled and increase the operation complexity of operator.
In sum although the present invention is disclosed as above with preferred embodiment, so it is not limited to the present invention, ability
Field technique personnel are it should be recognized that without departing from the scope and spirit of the present invention disclosed in appended claims of the invention
In the case of the change made and retouching, all belong within the scope of the claims of the present invention.
Claims (9)
1. a kind of extracorporeal circulation life support equipment, for giving treatment to multiple organ dysfunction syndrome, described extracorporeal circulation life is supported to set
Standby be formed with the vein being connected to patient or tremulous pulse goes out the extracorporeal circulation pipeline that the vein of end and patient enters between end, described external
First blood pump, the second blood pump are disposed with circulation line, described extracorporeal circulation pipeline is in described first blood pump, the second blood pump
Between branch into may be selected entrance tie point and the second branch road；
Oxygenator is provided with described tie point, the vein described in blood flowing after oxygen closes enters end；
On described second branch road, the downstream branch of described second blood pump is separation branch road and the filtration branch road that may be selected to enter, described
Separate and be provided with plasma separator on branch road, described filtration branch road is provided with hemofiltration with the described meet separating branch road
Device, has blood plasma branch road between described plasma separator and described filtration branch road；
The blood cell that described plasma separator is isolated flows into described blood through the described downstream separating described plasma separator on branch road
Liquid filter, the blood plasma that described plasma separator is isolated flows to described blood through described blood plasma branch road and described filtration branch road successively
Liquid filter；
The venous blood described in blood flowing of described transfusion filterses filtration enters end；
Wherein, in described tie point, the upstream of described oxygenator is provided with the first blood folder, described blood plasma on described separation branch road
The upstream of separator is provided with the second blood folder, and described filtration branch road is provided with the 3rd blood folder, and the blood plasma of described blood plasma branch road is from institute
The downstream stating the 3rd blood folder flows to described transfusion filterses.
2. extracorporeal circulation life support equipment as claimed in claim 1 it is characterised in that described first blood pump be air driven pump,
The Hemodynamic environment of described first blood pump is 4 liters every point, and described second blood pump is roll pump, the Hemodynamic environment of described second blood pump is 0～
500 milliliters every point.
3. extracorporeal circulation life support equipment as claimed in claim 2 is it is characterised in that the Hemodynamic environment of described first blood pump is
4 liters every point, the Hemodynamic environment of described second blood pump is every point of 150-500 milliliter.
4. extracorporeal circulation life support equipment as claimed in claim 3 is it is characterised in that the Hemodynamic environment of described second blood pump is
400 milliliters every point, the Hemodynamic environment of described filtration branch road controls at 250 milliliters every point, and the Hemodynamic environment separating on branch road controls
150 milliliters every point.
5. extracorporeal circulation life support equipment as claimed in claim 1 is it is characterised in that be provided with described blood plasma branch road：
Resin container and/or absorbent charcoal adsorption tank；And/or
The adsorption tanks for the treatment of sepsis, rheumatological disease and/or poisoning.
6. extracorporeal circulation life support equipment as claimed in claim 1 is it is characterised in that also include warmer, be arranged at
At at least one of lower position：
The downstream of described first blood pump on main line；
Described tie point；
Described filtration branch road, described separation branch road point and described vein enter between end.
7. extracorporeal circulation life support equipment as claimed in claim 1 is it is characterised in that described extracorporeal circulation life is supported to set
Getting everything ready has a mainframe box, and described mainframe box appearance is integrated with plasma separator, transfusion filterses, oxygenator and each described blood pump
Panel, to be uniformly controlled and to automatically control plasma separator, transfusion filterses, oxygenator and each described by computer program
Blood pump, described mainframe box desktop has the operation interface of function selecting, parameter setting, monitoring display and control selections.
8. extracorporeal circulation life support equipment as claimed in claim 7 it is characterised in that
Described oxygenator is membrane oxygenator；
Between described second blood pump and described plasma separator, on blood plasma branch road, it is provided with pressure monitor；
The downstream of the upstream of described first blood pump or described second blood pump is provided with heparin pump；
On described filtration branch road, the downstream of described transfusion filterses is provided with vein pressure table and fluid balancing device.
9. extracorporeal circulation life support equipment as claimed in claim 7 is it is characterised in that described plasma separator, blood are filtered
The panel crossing device, oxygenator and each described blood pump includes controlling described plasma separator, transfusion filterses, oxygenator and each institute
State the panel of the internal circuit of blood pump.
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| CN201510218620.7A CN104800902B (en) | 2015-04-30 | 2015-04-30 | Extracorporeal circulation life supporting device for treating and curing multiple organ failure |
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| CN105497999A (en) * | 2016-01-25 | 2016-04-20 | 张伟 | Lymph purification therapeutic apparatus |
| DE102017210134A1 (en) * | 2016-12-15 | 2018-06-21 | Fresenius Medical Care Deutschland Gmbh | Extracorporeal blood treatment system, treatment device, kit and method for operating an extracorporeal blood treatment system |
| CN108211032B (en) * | 2018-02-01 | 2023-11-17 | 南方医科大学珠江医院 | Combined bioartificial liver support system |
| CN108451553A (en) * | 2018-03-21 | 2018-08-28 | 成都康拓邦科技有限公司 | Cerebral apoplexy operation device and system |
| CN108635631A (en) * | 2018-05-28 | 2018-10-12 | 广东药科大学 | Four limbs harmful substance pass filter |
| CN110538353A (en) * | 2019-08-19 | 2019-12-06 | 江苏赛腾医疗科技有限公司 | In vitro heart lung support auxiliary system |
| CN111436955A (en) * | 2019-12-16 | 2020-07-24 | 成都市佳颖医用制品有限公司 | Blood collection and separation device and control system |
| CN111166953A (en) * | 2020-02-03 | 2020-05-19 | 深圳汉诺医疗科技有限公司 | Extracorporeal circulation system and method for purifying blood |
| CN111840780B (en) * | 2020-06-24 | 2022-07-12 | 安徽通灵仿生科技有限公司 | Line adapter suitable for blood purification device during ECMO |
| CN112007226A (en) * | 2020-07-13 | 2020-12-01 | 北京西峰科技有限责任公司 | Blood extracorporeal circulation life support system |
| CN114907972A (en) * | 2021-02-09 | 2022-08-16 | 苏州心擎医疗技术有限公司 | Multi-organ in-vitro life support system |
| CN116617482A (en) * | 2023-04-28 | 2023-08-22 | 天津大学温州安全(应急)研究院 | ECMO combined blood purification device for animals and application method thereof |
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| US5277820A (en) * | 1992-02-06 | 1994-01-11 | Hemocleanse, Inc. | Device and method for extracorporeal blood treatment |
| DE19622184A1 (en) * | 1996-06-03 | 1997-12-04 | Joern Martens | Portable device for long term perfusion of human and animal tissue e.g. heart lung kidney and liver machine |
| JP3924449B2 (en) * | 2001-10-05 | 2007-06-06 | 旭化成メディカル株式会社 | Blood purification equipment |
| CN100486651C (en) * | 2007-04-27 | 2009-05-13 | 高光勇 | Multiple organ dysfunction support system |
| CN203169677U (en) * | 2013-04-02 | 2013-09-04 | 周春华 | Self-balance substitution device for multi-organ supporting |
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