CN104800902A - Extracorporeal circulation life supporting device for treating and curing multiple organ failure - Google Patents
Extracorporeal circulation life supporting device for treating and curing multiple organ failure Download PDFInfo
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- CN104800902A CN104800902A CN201510218620.7A CN201510218620A CN104800902A CN 104800902 A CN104800902 A CN 104800902A CN 201510218620 A CN201510218620 A CN 201510218620A CN 104800902 A CN104800902 A CN 104800902A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
Abstract
The invention discloses an extracorporeal circulation life supporting device used for treating and curing multiple organ failure. The extracorporeal circulation life supporting device comprises an extracorporeal circulation pipeline which is connected between a vein or artery outlet end of a patient and a vein blood inlet end of the patient; a heparin pump, a first blood pump and a second blood pump are arranged on the extracorporeal circulation pipeline in turn; the extracorporeal circulation pipeline is branched into a first branch and a second branch between the first blood pump and the second blood pump; an oxygen combiner is arranged on the first branch; the second branch extends from the second blood pump which is provided with a blood clamp, a plasma separator, an active carbon jar and a resin jar are arranged at the lower edge of the second blood pump; the plasma outputted from a side wall of the plasma separator enters into the active carbon jar and the resin jar and enters into a blood filter together with the blood cells outputted from an outlet end of the plasma separator; the blood is purified and is applied to a supporting device for curing renal failure; all the branches are converged and enter into the body of the patient from the vein end. According to the extracorporeal circulation life supporting device, one device is used for independently or jointly supporting/replacing the heart, lung, liver and renal function failure.
Description
Technical field
The present invention relates to extracorporeal circulation life support technology field, particularly relating to a kind of extracorporeal circulation life support equipment for giving treatment to multiple organ dysfunction syndrome.
Background technology
At medical domain, extracorporeal life support is a kind of important Medical Technology.
Extracorporeal life supports (Extracorporeal Life Support, being called for short ELS) etymology is in foreign literature, in prior art, clinical indication cardio-pulmonary function support equipment is ertro corporeal membrane oxygenation (Extracorporeal membrane oxygenation mainly, be called for short ECMO), other clinical organ failure's support equipment, comprise respirator, Continuous renal replacement therapy (Continuous renal replacementtherapy is called for short CRRT) equipment and artificial liver etc.
ECMO is first by the driving function of the blood of ECMO, blood is drained into extracorporeal circulation in body, after artificial membrane lung oxygenate, again oxygenated blood is fed in body, to maintain the oxygen supply of each organ of body, can support for a long time serious reversibility respiratory failure and heart failure patient, make Patients with Lung or cardiopulmonary be able to sufficient rest, for the recovery of lung or cardio-pulmonary function tries to gain time precious to one.Therefore, ECMO is mainly used in the recovery that postcardiac surgery maintains cardio-pulmonary function, also for other reversibility cardiopulmonary exhaustion (during cardiorespiratory failure as caused in heart infarction, sudden death, pulmonary embolism etc.), and adult respiratory distress syndrome (ARDS).The maximum shortcoming of ECMO can not support hepatic and renal function
CRRT is main blood cleaning equipment, to the patient of renal failure, can substitute renal function completely in the regular period.Domestic application CRRT, at Urology Department and intensive care unit (ICU), treats how dirty (heart kidney liver failure) and the adult respiratory distress syndrome (ARDS) of declining.
Artificial liver technology, refer to that plasmapheresis and blood purification, adsorption technology combine, namely there is septicemia element be eliminated external or be adsorbed onto the carrier that has and enrich surface area uses and remove from blood, domestic artificial liver helps to carry out in hepatopathy section or kidney section, and Liver and kidney exhaustion is simultaneously completed by kidney section.
In medical clinical practice, in view of how dirty (the cardiopulmonary kidney liver) patient that declines at ICU, CCU (coronary heart disease Intensive Care Therapy) increases, but the not multi-functional equipment of a kind of collection separately in prior art, can assist or the function of alternative multiple organs failure.
The extracorporeal circulation support equipments such as above-mentioned ECMO, CRRT of prior art, all have single internal organs and support function, can tackle single Organ Failure.
Between the said equipment, existing connected mode is external combination, and such as ECMO combines with transfusion filters, merges renal failure for cardiopulmonary exhaustion; And CRRT and ECMO combines, be used for the treatment of kidney liver failure and cardiopulmonary exhaustion.In a word, there is no the inherent associating clinical practice of this kind equipment at present both at home and abroad.ECMO and CRRT was two independently outside individual associatings respectively in the past, did not have inherent multiple function to concentrate on a machine.
In the ward of the limited area of ICU, CCU, in the face of the patient of various organ failure, and also may there is the organ failure of other new type in patient over the course for the treatment of, therefore, the extracorporeal circulation support equipment of existing simple function, has inconvenience when tackling above-mentioned situation.The connection of equipment moving and equipment room same control device frequently, not only can stop over the time of giving treatment to patient, also can increase the operation complexity of operator owing to not easily realizing unified control between distinct device.
To sum up, the extracorporeal circulation life support equipment of prior art exists can not be unified to control, and need the technical problem reconnected by multiple equipment, the present invention is that several functions concentrates on a machine, and is automatically controlled by computer and selectable multifunctional treating system.
Summary of the invention
For problems of the prior art, object of the present invention is for providing a kind of Multifunctional external cycle life support equipment.
For reaching above-mentioned purpose, comparatively broad embodiment of the present invention is for providing a kind of extracorporeal circulation life support equipment, for giving treatment to multiple organ dysfunction syndrome, described extracorporeal circulation life support equipment be formed vein that the vein that is connected to patient or tremulous pulse go out end and patient enter to hold between extracorporeal circulation pipeline, described extracorporeal circulation pipeline is disposed with the first blood pump, the second blood pump, described extracorporeal circulation pipeline branches into the first branch road and the second branch road that can select to enter between described first blood pump, the second blood pump; Described first branch road is provided with oxygenator, and vein described in the blood flowing after oxygenate enters end; On described second branch road, the downstream branch of described second blood pump is the separation branch road and filtration branch road that can select to enter, described separation branch road is provided with plasma separator, described filtration branch road is provided with transfusion filters with the described meet being separated branch road, has blood plasma branch road between described plasma separator and described filtration branch road; The downstream of the isolated blood cell of described plasma separator described plasma separator on described separation branch road flows into described transfusion filters, and the isolated blood plasma of described plasma separator flows to described transfusion filters through described blood plasma branch road and described filtration branch road successively; Described in the blood flowing that described transfusion filters filters, venous blood enters end.
Extracorporeal circulation life support equipment of the present invention, preferably, on described first branch road, the upstream of described oxygenator is provided with the first blood folder, on described separation branch road, the upstream of described plasma separator is provided with the second blood folder, described filtration branch road is provided with the 3rd blood folder, and the blood plasma of described blood plasma branch road flows to described transfusion filters from the downstream of described 3rd blood folder.
Extracorporeal circulation life support equipment of the present invention, preferably, described first blood pump is air driven pump, and the Hemodynamic environment of described first blood pump is 4 liters of per minutes, and described second blood pump is roll pump, and the Hemodynamic environment of described second blood pump is 0 ~ 500 milliliter of per minute.
Extracorporeal circulation life support equipment of the present invention, preferably, the Hemodynamic environment of described first blood pump is 4 liters of per minutes, and the Hemodynamic environment of described second blood pump is 150-500 milliliter per minute.
Extracorporeal circulation life support equipment of the present invention, preferably, the Hemodynamic environment of described second blood pump is 400 milliliters of every timesharing, and the Hemodynamic environment of described filtration branch road controls at 250 milliliters of per minutes, and the Hemodynamic environment be separated on branch road controls at 150 milliliters of per minutes.
Extracorporeal circulation life support equipment of the present invention, preferably, selectablely on described blood plasma branch road to be provided with: resin container and/or absorbent charcoal adsorption tank; Treatment sepsis, rheumatological disease, poisoning adsorption tanks.
Extracorporeal circulation life support equipment of the present invention, preferably, also comprises warmer, is arranged at least one place with upper/lower positions: the downstream of described first blood pump on main line; Described first branch road; Described filtration branch road, between described separation branch road point and described venous inlet.
Extracorporeal circulation life support equipment of the present invention, preferably, described extracorporeal circulation life support equipment has a mainframe box, described mainframe box appearance is integrated with the panel of plasma separator, transfusion filters, oxygenator and each described blood pump, to control by computer program is unified and automatically controls plasma separator, transfusion filters, oxygenator and each described blood pump, described mainframe box desktop has the operation interface that function selecting, parameter setting, monitoring display and control are selected.
Extracorporeal circulation life support equipment of the present invention, preferably, described oxygenator is membrane oxygenator; Between described second blood pump and described plasma separator, blood plasma branch road is provided with pressure monitor; The upstream of described first blood pump or the downstream of described second blood pump are provided with heparin pump; On described filtered solution branch road, the downstream of described transfusion filters is provided with vein pressure table and fluid balancing device.
Extracorporeal circulation life support equipment of the present invention, preferably, the panel of described plasma separator, transfusion filters, oxygenator and each described blood pump comprises the panel of the internal circuit controlling described plasma separator, transfusion filters, oxygenator and each described blood pump.
Beneficial effect of the present invention is, extracorporeal circulation life support equipment of the present invention, is the extracorporeal circulation life support equipment of a tractor serves several purposes.Be exactly by an equipment, separately or combine supports/alternative heart, lung, Liver and kidney function exhaustion.
Extracorporeal circulation life support equipment of the present invention is not the development of ECMO function and widening of indication, neither how dirty the external therapeutic alliance of ECMO and CRRT is declines.But the function inherence of ECMO and CRRT be combined into a machine, by the procedural combination of unified conputer controlled, collect multi-functional in a machine, can to select separately or multiple organ is supported (after one's own heart, the function support of lung, liver, kidney) simultaneously.Extracorporeal circulation life support equipment of the present invention, except for except the how dirty treatment declined, can also treat sepsis, rheumatological disease, poisoning etc. (depend on and select different adsorption tanks).
Extracorporeal circulation life support equipment of the present invention, when being arranged in ICU, CCU ward, the patient of various organ failure can be successfully managed, even if there is the organ failure of other new type over the course for the treatment of in patient, do not have the connection of equipment moving and equipment room same control device frequently, the time that patient is given treatment to can not be stopped over, also can not increase the operation complexity of operator due to unified control can not be realized between distinct device.
Accompanying drawing explanation
Fig. 1 is the schematic diagram of the extracorporeal circulation life support equipment of the embodiment of the present invention.
Fig. 2 is that the extracorporeal circulation life support equipment of the embodiment of the present invention carries out separately the circulation road of cardio-pulmonary function support through schematic diagram.
Fig. 3 is that the extracorporeal circulation life support equipment of the embodiment of the present invention carries out the circulation road of cardiopulmonary renal function support through schematic diagram.
Fig. 4 is that the extracorporeal circulation life support equipment of the embodiment of the present invention carries out the circulation road of cardiopulmonary liver function support through schematic diagram.
Fig. 5 is the line design schematic diagram of the extracorporeal circulation life support equipment of the embodiment of the present invention.
Detailed description of the invention
Some typical cases embodying feature & benefits of the present invention implement case and describe in detail in the explanation of back segment.Be understood that the present invention can have various different treatment function on different Implementation Modes, so it neither departs from the scope of the present invention, and explanation wherein and accompanying drawing are in itself when the use explained, and is not used to limit the present invention.
The present invention preferably implements the extracorporeal circulation life support equipment of case, as Figure 1-Figure 5, comprise vein or tremulous pulse outlet 100, venous inlet 700, and be connected to vein or the extracorporeal circulation pipeline between tremulous pulse outlet 100 and venous inlet 700, the first blood pump 201, second blood pump 801 in vitro circulation circulation line arranged and the capital equipment such as plasma separator 402, transfusion filters 503.
As shown in Figure 1, extracorporeal circulation circulation line comprises main line 200, first branch road 300, second branch road 800, is separated branch road 400, filters branch road 500 and blood plasma branch road 450 etc.
Wherein, be whole blood in main line 200 in flowing, be provided with heparin pump 202, certainly, also on the second branch road 800, heparin pump 804 can be set the downstream of the second blood pump 801, in case hemostasis-coagulation.And blood plasma branch road 450 is blood plasma flowings, and being separated the downstream of plasma separator 402 on branch road 400, is then blood cell flowing.
As shown in Figure 1, in the downstream of the first blood pump 201, main line 200 branches into the first branch road 300 and the second branch road 800, second blood pump 801 is arranged on the second branch road 800.First branch road 300 finally flows back to venous inlet 700, and the second branch road 800 branches into separation branch road 400 and filters branch road 500, is more also connected to venous inlet 700 after converging.And be separated branch road 400 and filter between branch road 500, be also provided with blood plasma branch road 450.
First branch road 300 is provided with oxygenator 301, first blood folder 302, also can warmer 303 be set again.Wherein, the first blood folder 302 is arranged on the upstream of oxygenator 301; Upstream mentioned here is that the position that blood first flows through is upstream position with the direction of pipeline inner blood or blood component flow, after the position that flows through be downstream position.And oxygenator 301, then preferably membrane oxygenator, also i.e. membrane lung.
Be separated on branch road 400 and be provided with plasma separator 402, plasma separator 402 has two-way to export, one tunnel is export to the downstream being separated plasma separator 402 on branch road 400, what export is the isolated blood cell of plasma separator 402, another road is then by blood plasma branch road 450, filtration branch road 500, flow to transfusion filters 503, namely allow blood cell and blood plasma all be filtered by transfusion filters 503.
Be separated the upstream of plasma separator 402 on branch road 400, be provided with the second blood folder 401, filter branch road 500 and be provided with the 3rd blood folder 501, if do not need blood plasma to be separated and adsorbing therapy, close the second blood folder 401, blood filters branch road 500 from descending directly the entering of the second blood pump 801, when the 3rd blood folder 501 is opened, enter transfusion filters 503, through hemofiltration process, again through fluid balancing device 502 and vein pressure table 504, the blood of purification is got back in patient body from venous inlet 700.As shown in Figure 3.
As shown in Figure 1, the extracorporeal circulation life support equipment of the embodiment of the present invention, be connected with the meet being separated branch road 400 supportive device being used for the treatment of renal failure at filtration branch road 500, be also transfusion filters 503, the downstream filtering branch road 500 is also connected to venous inlet 700.The extracorporeal circulation life support equipment of the embodiment of the present invention, can only have renal failure supportive device, or has renal failure supportive device and liver failure supportive device simultaneously, but preferably, has both had liver failure supportive device, has again renal failure supportive device.Wherein, renal failure supportive device is Treated with High Volume Hemofiltration machine (HVHF) 503 preferably, and the charcoal canister 452 that liver failure supportive device preferably blood plasma branch road 450 is arranged in series mutually and resin container 453, also i.e. artificial liver.
The extracorporeal circulation life support equipment of the embodiment of the present invention, can also be used for the treatment of sepsis, rheumatological disease, poisoning etc.At this moment, can on blood plasma branch road 450 additional resin tank and various immunoadsorption tank, sepsis, rheumatological disease, poisoning etc. can be treated.
As shown in Figure 1, on the first branch road 300, the upstream of oxygenator 301 is provided with the first blood folder 302, and separation branch road 400 in blood cell side is provided with the second blood folder 401, filters on branch road 500 and is provided with the 3rd blood folder 501.The effect of the first blood folder 302, second blood folder 401 and the 3rd blood folder 501 is the branch road blocking or open respective place, the extracorporeal circulation life support equipment of the embodiment of the present invention is made to have different circulation road warps, to tackle organ failure patient that is dissimilar and combination.Blood pump also can replace blood to press from both sides.
By the control to the first blood folder 302, second blood folder 401 and the 3rd blood folder 501, combine the control to the first blood pump 201 and the second blood pump 801 again, what can be implemented in different blood in extracorporeal circulation pipeline or blood constituent flows through path, to tackle organ failure patient that is dissimilar and combination.
Wherein, for the first blood pump 201 and the second blood pump 801, if when blood pump drives function is opened, the first blood pump 201 and the 801 pairs of extracorporeal circulations of the second blood pump provide power.
Wherein, the first blood pump 201 preferably air driven pump, the Hemodynamic environment of the first blood pump 201 is 4 liters of per minutes, its have without blood cell damage or blood cell damage light advantage, the second blood pump 801 can be roll pump, and the Hemodynamic environment of the second blood pump 801 is 0 ~ 500 milliliter of per minute.Described extracorporeal circulation, when carrying out low discharge extraction, the Hemodynamic environment of the first blood pump 201 and the second blood pump 801 can be 200 ~ 400 milliliters of per minutes.
For the patient of cardiopulmonary renal failure or cardiopulmonary liver failure, preferably, the Hemodynamic environment of the first blood pump 201 is 4 liters of per minutes, and the Hemodynamic environment of the second blood pump 801 is 150 ~ 500 milliliters of per minutes.Preferably, the Hemodynamic environment that second blood pump 801 controls the second branch road 800 is 400 milliliters of every timesharing, the Hemodynamic environment filtering branch road 500 can be controlled in 250 milliliters of per minutes, and the Hemodynamic environment be separated on branch road 400 controls at 150 milliliters of per minutes, can be controlled this Hemodynamic environment by blood pump 456, as shown in Figure 5.
Below the extracorporeal circulation circulating path to all types of organ failure is described respectively.
First, for simple cardiopulmonary failure patients, the extracorporeal circulation life support equipment of the embodiment of the present invention, when carrying out extracorporeal circulation life and supporting, needs control first blood pump 201 to open flow velocity 4L per minute, and control the second blood pump 801 is closed, now, the circulation road of extracorporeal circulation pipeline is through as shown in Figure 2, and the blood flowed out from the tremulous pulse of patient is through main line 200, through the pumping of the first blood pump 201, flow back to the venous inlet 700 of patient from the first branch road 300.When flowing through the first branch road 300, blood plays Oxygenation through oxygenator 301, to provide the support of extracorporeal circulation life to cardiopulmonary failure patients.
And cardiopulmonary exhaustion is merged to the patient of liver, renal failure, then need to open the first blood pump 201 and the second blood pump 801 simultaneously.The Hemodynamic environment that first blood pump 201 can control main line 200 is 4 liters of per minutes, the Hemodynamic environment that second blood pump 801 controls is such as 400 milliliters of per minutes, also the i.e. blood that exports of the first blood pump 201, most blood is refluxed by oxygenator 301 by the first branch road 300 venous inlet 700 of patient.And the second blood pump 801 controls Hemodynamic environment 400 milliliters of per minutes, wherein part blood enters with the Hemodynamic environment of 150 milliliters of per minutes and is separated branch road 400, enters plasma separator 402 and adsorption tanks 453,452.Open 3rd blood folder 501, make residual blood enter transfusion filters 503 with the Hemodynamic environment of 250 milliliters of per minutes, carry out hemofiltration, effluent discharge, the blood of purification finally enters venous inlet 700.
If patient does not have cardiopulmonary exhaustion, such as simple liver failure, then the first blood pump 201 (controlling Hemodynamic environment 200 ~ 300 milliliters of per minutes) blood out directly enters the plasma separator 402 being separated branch road 400, and the adsorption tanks 453,452 (artificial liver) that isolated blood plasma enters blood plasma branch road 450 carry out adsorbing therapy.If simple renal failure, then directly enter the transfusion filters 503 filtering branch road 500 and carry out Hemofiltration for Treatment.
For simple patients with renal failure, control the first blood pump 201, and the first blood folder 302 of the first branch road 300 and the second blood folder 401 be separated on branch road 400 will be closed, block the first branch road 300 and be separated branch road 400, opening the 3rd blood folder 501.Now, blood filters through Treated with High Volume Hemofiltration device 503, to provide the support of extracorporeal circulation life to patients with renal failure, from the venous inlet 700 of transfusion filters 503 blood flowing patient out.
For simple hepatic failure patients, the Hemodynamic environment adjusting the first blood pump 201 is 200-300 milliliter per minute, and close the first blood folder 302, block the first branch road 300, open the second blood folder 401, make blood plasma by plasma separator 402, enter plasma separator 402 and immunoadsorption tank 453 and absorbent charcoal adsorption tank 452, enter venous inlet 700.Now, the 3rd blood folder 501 cuts out, but the downstream not affecting isolated blood plasma the 3rd blood folder 501 on filtration branch road 500 in plasma separator 402 flows into transfusion filters 503.
Cardiopulmonary exhaustion is merged to the patient of renal failure, the extracorporeal circulation life support equipment of the embodiment of the present invention, when carrying out extracorporeal circulation life and supporting, as shown in Figure 3, need the Hemodynamic environment of control first blood pump 201 to be 4L per minute, open the second blood pump 801 simultaneously, its Hemodynamic environment 200 milliliters of per minutes, open first blood folder 302, blood enters the first branch road 300, enters membrane lung; Close the second blood folder 401 being separated branch road 400, open 3rd blood folder 501, makes blood enter and filters branch road 500, by transfusion filters 503.Now, the circulation road of the extracorporeal circulation pipeline of the extracorporeal circulation life support equipment of the invention process case is through as shown in Figure 3, the blood flowed out from the tremulous pulse of patient, through main line 200, through the pumping of the first blood pump 201, makes blood from the first branch road 300 and by oxygenator 301.Open 3rd blood folder 501, blood enters and filters branch road 500, and carries out blood purification by transfusion filters 503, then flows back to the venous inlet 700 of patient.When flowing through the first branch road 300, blood plays Oxygenation through oxygenator 301; And when flowing through filtration branch road 500, carry out hemofiltration through Treated with High Volume Hemofiltration device 503, provide the support of extracorporeal circulation life with patient cardiopulmonary exhaustion being merged to renal failure.
Cardiopulmonary exhaustion is merged to the patient of liver failure, the extracorporeal circulation life support equipment of the embodiment of the present invention, when carrying out extracorporeal circulation life and supporting, as shown in Figure 4, need control first blood pump 201 Hemodynamic environment 4 liters of per minutes, open and control the second blood pump 801, its Hemodynamic environment 200 milliliters of per minutes, the first blood folder 302 is opened, and blood passes through membrane lung on the first branch road 300, second blood folder 401 is opened, and closes the 3rd blood folder 501.Blood filtration branch road 400 on blood through plasma separator 402, the side opening of plasma separator 402, also the position blood plasma out that namely plasma separator 402 is connected with blood plasma branch road 450 enters adsorption tanks 452,453, through adsorption, through blood plasma branch road 450, filter branch road 500, get back in patient body from venous inlet 700.Transfusion filters 503 is entered through being separated branch road 400 by plasma separator 402 blood cell out, do according to clinical needs or do not do blood purification, therefore, converge from filtering branch road 500 blood plasma of coming with from being separated the blood cell that branch road 400 comes, whole blood filters through transfusion filters 503, returns in body after filtration.Now, the circulation road of extracorporeal circulation pipeline is through as shown in Figure 4, the blood flowed out from the vein of patient, through main line 200, through the pumping of the first blood pump 201, branches into the first branch road 300, enter membrane lung, and the blood of the second branch road 800, then enter and be separated branch road 400, enter plasma separator 402, from plasma separator 402 side opening blood plasma out, after entering adsorption tanks 452,453, enter transfusion filters 503; Enter from plasma separator 402 sidewall blood cell out and be separated branch road 400, also enter transfusion filters 503.In a word, when flowing through the first branch road 300, blood plays Oxygenation through oxygenator 301; And when flowing through blood plasma branch road 400, blood plasma, through the absorption of resin container 453 and absorbent charcoal adsorption tank 452, provides the support of extracorporeal circulation life with patient cardiopulmonary exhaustion being merged to liver failure.
The extracorporeal circulation life support equipment of the embodiment of the present invention, in the specific implementation, the design of its each branch road, pipeline can as shown in Figure 5, be summarized as follows:
For main line 200, it is arranged the first blood pump 201.The end of main line 200, branches into the first branch road 300 and the second branch road 800 by a threeway.
On first branch road 300, oxygenator 301, warmer 303 and the first blood folder 302 is set.
Second branch road 800 is provided with the second blood pump 801 and heparin pump 202.
Second branch road 800 branches into and is separated branch road 400 and filters branch road 500.
For being also provided with blood folder 401 and the first controllable type pressure monitor 403 between separation branch road 400, second blood pump 801 and plasma separator 402, to monitor the real-time pressure of the second branch road 800.On blood plasma branch road 450, pressure monitor 455 can be set.
As shown in Figure 5, before being separated the converging of branch road 400 and the first branch road 300, in the downstream of transfusion filters 503, gas bubble detection 407 can be provided with.And the point of the first branch road 300, separation branch road 400 and filtration branch road 500, and between venous inlet 700, filter 305 and warmer 306 can be set, the effect of warmer 306 is that the temperature of blood and human body temperature are coincide.
In addition, Treated with High Volume Hemofiltration device 503 downstream also can arrange liquid discrepancy bascule 502, to carry out fluid infusion.Blood and the supplementary displacement liquid of purification finally converge, then converge with the first branch road 300, enter vein and enter in end 700 ex vivo.
In the waste liquid side of transfusion filters 503, be respectively arranged with blood pump 901, mixed-blood detector 902, claim 903 and waste liquid chamber 904; In the displacement liquid side of transfusion filters 503, be respectively arranged with warmer 905, blood pump 906, claim 907 and displacement sap cavity 908.
The extracorporeal circulation life support equipment of the embodiment of the present invention is the extracorporeal circulation life support equipment of a tractor serves several purposes.Be exactly by an equipment, separately or combine multi-functional support/substitute the heart, lung, Liver and kidney function exhaustion.
Extracorporeal circulation life support equipment of the present invention is not the development of ECMO function and widening of indication, neither how dirty the external therapeutic alliance of ECMO and CRRT is declines.But the function inherence of ECMO and CRRT be combined into a machine, by the procedural combination of same conputer controlled, be multi-functional in a machine, can select separately or multiple organ is supported (after one's own heart, the function support of lung, liver, kidney) simultaneously.Extracorporeal circulation life support equipment of the present invention, except for except the how dirty treatment declined, can also treat sepsis, rheumatological disease, poisoning etc.
The extracorporeal circulation life support equipment of the embodiment of the present invention, there is a mainframe box, described mainframe box is integrated with the panel of plasma separator 402, transfusion filters 503, oxygenator 301 and each blood pump 201,801 etc., to control by computer program is unified and automatically controls plasma separator 402, transfusion filters 503, oxygenator 302 and each blood pump 201,801, mainframe box has the operation interface that function selecting, parameter setting, monitoring display and control are selected.And above-mentioned panel, comprise the panel of the internal circuit controlling plasma separator 402, transfusion filters 503, oxygenator 301 and each blood pump 201,801.
Extracorporeal circulation life support equipment of the present invention, when being arranged in ICU, CCU ward, the patient of various organ failure can be successfully managed, even if there is the organ failure of other new type over the course for the treatment of in patient, do not have equipment moving and equipment frequently to reconnect, the time that patient is given treatment to can not be stopped over, also can not increase the operation complexity of operator due to unified control can not be realized between distinct device.
In sum; although the present invention discloses as above with preferred embodiment; so itself and be not used to limit the present invention; the change that those skilled in the art do when should recognize the scope and spirit of the present invention disclosed in the claim do not departed from appended by the present invention and retouching, within the protection domain all belonging to claim of the present invention.
Claims (10)
1. an extracorporeal circulation life support equipment, for giving treatment to multiple organ dysfunction syndrome, described extracorporeal circulation life support equipment be formed vein that the vein that is connected to patient or tremulous pulse go out end and patient enter to hold between extracorporeal circulation pipeline, described extracorporeal circulation pipeline is disposed with the first blood pump, the second blood pump, described extracorporeal circulation pipeline branches into the first branch road and the second branch road that can select to enter between described first blood pump, the second blood pump;
Described first branch road is provided with oxygenator, and vein described in the blood flowing after oxygenate enters end;
On described second branch road, the downstream branch of described second blood pump is the separation branch road and filtration branch road that can select to enter, described separation branch road is provided with plasma separator, described filtration branch road is provided with transfusion filters with the described meet being separated branch road, has blood plasma branch road between described plasma separator and described filtration branch road;
The downstream of the isolated blood cell of described plasma separator described plasma separator on described separation branch road flows into described transfusion filters, and the isolated blood plasma of described plasma separator flows to described transfusion filters through described blood plasma branch road and described filtration branch road successively;
Described in the blood flowing that described transfusion filters filters, venous blood enters end.
2. extracorporeal circulation life support equipment as claimed in claim 1, it is characterized in that, on described first branch road, the upstream of described oxygenator is provided with the first blood folder, on described separation branch road, the upstream of described plasma separator is provided with the second blood folder, described filtration branch road is provided with the 3rd blood folder, and the blood plasma of described blood plasma branch road flows to described transfusion filters from the downstream of described 3rd blood folder.
3. extracorporeal circulation life support equipment as claimed in claim 2, it is characterized in that, described first blood pump is air driven pump, and the Hemodynamic environment of described first blood pump is 4 liters of per minutes, described second blood pump is roll pump, and the Hemodynamic environment of described second blood pump is 0 ~ 500 milliliter of per minute.
4. extracorporeal circulation life support equipment as claimed in claim 3, it is characterized in that, the Hemodynamic environment of described first blood pump is 4 liters of per minutes, and the Hemodynamic environment of described second blood pump is 150-500 milliliter per minute.
5. extracorporeal circulation life support equipment as claimed in claim 4, it is characterized in that, the Hemodynamic environment of described second blood pump is 400 milliliters of per minutes, and the Hemodynamic environment of described filtration branch road controls at 250 milliliters of per minutes, and the Hemodynamic environment be separated on branch road controls at 150 milliliters of per minutes.
6. extracorporeal circulation life support equipment as claimed in claim 1, is characterized in that, selectablely on described blood plasma branch road is provided with:
Resin container and/or absorbent charcoal adsorption tank;
Treatment sepsis, rheumatological disease, poisoning adsorption tanks.
7. extracorporeal circulation life support equipment as claimed in claim 1, is characterized in that, also comprise warmer, be arranged at least one place with upper/lower positions:
The downstream of described first blood pump on main line;
Described first branch road;
Described filtration branch road, between described separation branch road point and described venous inlet.
8. extracorporeal circulation life support equipment as claimed in claim 1, it is characterized in that, described extracorporeal circulation life support equipment has a mainframe box, described mainframe box appearance is integrated with the panel of plasma separator, transfusion filters, oxygenator and each described blood pump, to control by computer program is unified and automatically controls plasma separator, transfusion filters, oxygenator and each described blood pump, described mainframe box desktop has the operation interface that function selecting, parameter setting, monitoring display and control are selected.
9. extracorporeal circulation life support equipment as claimed in claim 8, is characterized in that,
Described oxygenator is membrane oxygenator;
Between described second blood pump and described plasma separator, blood plasma branch road is provided with pressure monitor;
The upstream of described first blood pump or the downstream of described second blood pump are provided with heparin pump;
On described filtered solution branch road, the downstream of described transfusion filters is provided with vein pressure table and fluid balancing device.
10. extracorporeal circulation life support equipment as claimed in claim 8, it is characterized in that, the panel of described plasma separator, transfusion filters, oxygenator and each described blood pump comprises the panel of the internal circuit controlling described plasma separator, transfusion filters, oxygenator and each described blood pump.
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| WO2021031433A1 (en) * | 2019-08-19 | 2021-02-25 | 江苏赛腾医疗科技有限公司 | Extracorporeal membrane oxygenation system |
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| CN111840780A (en) * | 2020-06-24 | 2020-10-30 | 安徽通灵仿生科技有限公司 | Line adapter suitable for blood purification device during ECMO |
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| WO2022170937A1 (en) * | 2021-02-09 | 2022-08-18 | 苏州心擎医疗技术有限公司 | Multi-organ extracorporeal life support system |
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