CN103637787B - The method of blood pressure real-time measurement apparatus and in real time measurement pulse wave transmission time difference - Google Patents
The method of blood pressure real-time measurement apparatus and in real time measurement pulse wave transmission time difference Download PDFInfo
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Abstract
The present invention relates to a kind of blood pressure real-time measurement apparatus, comprising: the first pulse wave induction module, the second pulse wave induction module, and signal processing module, described first pulse wave induction module is for obtaining the first pulse wave signal of each cardiac cycle; Described second pulse wave induction module is for obtaining the second pulse wave signal of each cardiac cycle, and wherein said first pulse wave induction module is different from the type of the pulse wave that described second pulse wave induction module obtains; Described signal processing module for obtaining same artery position and transmission time difference between described first pulse wave signal obtained and the second pulse wave signal simultaneously, and obtains the arteriotony of each cardiac cycle according to this transmission time difference.
Description
Technical field
The present invention relates to the measuring method of a kind of blood pressure measuring device and pulse wave transmission time difference, particularly relate to the method for real-time measurement of a kind of blood pressure real-time measurement apparatus and pulse wave transmission time difference.
Background technology
Blood pressure is the important physiological parameter of reflection human recycle system function.The real-time measurement of blood pressure medically has great practical significance.First, the curve of cyclical fluctuations of human blood-pressure can reflect the relevant information of cardiovascular and cerebrovascular vessel physiological status, can as important reference data.Such as, the real-time blood pressure of hyperpietic directly reflects the health of patient, and therefore blood pressure is measured in real time and as important monitoring means, can be ensured that hyperpietic is given treatment to timely when sudden cardiovascular and cerebrovascular diseases.On clinical medicine, all need to the patient with severe symptoms in critical patient and operation the continuous monitoring carrying out blood pressure, once accident appears in patient, medical personnel can take effective rescue measure in time.But the blood pressure that Present clinical adopts monitors the measuring method normally adopting inflated type continuously, can only accomplish that per half an hour measures once, and the continuous monitoring of blood pressure can not be carried out.Moreover, the timing inflation and measure during nighttime sleep also seriously have impact on the rest of patient.
In the technical field that blood pressure is measured in real time, pulse wave transmission time method, the correlation models namely by setting up pulse wave transmission time and arteriotony calculates blood pressure, by a kind of method that can realize blood pressure continuous measurement generally admitted.
At present, method that blood pressure measures in real time mainly measures the pulse wave signal of electrocardiosignal and artery blood flow pulse simultaneously to utilize pulse wave transmission time method to carry out, obtain pulse wave according to the time difference of the characteristic point of two signals and propagate into from ventricle the transmission time that pulse wave measurement needs, i.e. the pulse wave transmission time.Arteriotony is obtained by measuring the pulse wave Time Calculation obtained.The pulse wave transmission time generally refers in same cardiac cycle, and the R wave-wave peak of electrocardiosignal is transferred to the time difference of artery to pulse wave.Typical using method adopts photoplethysmographic and electrocardiosignal to combine, and obtains the pulse wave transmission time, realize blood pressure and measure in real time.The deficiency that this method is measured has be measure electrocardiosignal need at human body many places Surface Mount electrode at three: one, and complicated operation, needs certain professional technique; Two is corresponding relations of R wave of electrocardiosignal and pulse wave crest is not very clear and definite, and the pulse wave transmission time calculated needs to revise; Three is that operation relates to the multiple position of human body, line health carrying many electrocardioelectrodes is not only needed during practical application, and the minor variations measuring posture and each measurement point relative position may change measurement and obtains the pulse wave transmission time, measurement result is caused to have certain error.
Summary of the invention
In view of this, necessaryly provide a kind of and can facilitate and Measure blood pressure and the blood pressure real-time measurement apparatus had compared with high measurement accuracy in real time.
A kind of blood pressure real-time measurement apparatus, comprising: the first pulse wave induction module, the second pulse wave induction module, and signal processing module, described first pulse wave induction module is for obtaining the first pulse wave signal of each cardiac cycle; Described second pulse wave induction module is for obtaining the second pulse wave signal of each cardiac cycle, and wherein said first pulse wave induction module is different from the type of the pulse wave of the acquisition of described first pulse wave induction module; Described signal processing module for obtaining same artery position and transmission time difference between described first pulse wave signal obtained and the second pulse wave signal simultaneously, and obtains the arteriotony of each cardiac cycle according to this transmission time difference.
A method for real-time measurement pulse wave transmission time difference, comprises the following steps: the first pulse wave signal responding to each cardiac cycle; Respond to the second pulse wave signal of each cardiac cycle, described first pulse wave signal is different from the pulse wave type of the second pulse wave signal; And obtain the transmission time difference of described first pulse wave signal that same artery position obtains simultaneously and the second pulse wave signal.
Compared with prior art, the pulse wave transmission time difference of the blood pressure real-time measurement apparatus that the embodiment of the present invention provides by adopting the different pulse wave induction module of two kinds of pulse waves induction type to respond to same artery position simultaneously, and according to the pressure value of each cardiac cycle of pulse wave transmission time difference Real-time Obtaining.This blood pressure real-time measurement apparatus first does not need to measure electrocardiosignal, does not therefore need the lead-in wire of electrocardioelectrode, measures in real time bring great convenience to blood pressure.Second, two kinds of dissimilar pulse wave signals take from tremulous pulse same position, thus the accuracy that blood pressure is measured in real time is high, and the 3rd, the measuring position of two kinds of pulse waves can be chosen according to the practical situation of patient, and the practical application for device provides very large motility.Such as, the individuals with disabilities losing both arms can measure at carotid artery place.
Accompanying drawing explanation
The functional block diagram of the blood pressure real-time measurement apparatus that Fig. 1 provides for the embodiment of the present invention.
The functional block diagram of the signal processing module in the blood pressure real-time measurement apparatus that Fig. 2 provides for the embodiment of the present invention.
The blood pressure real-time measurement apparatus of the wrist carried that Fig. 3 provides for the embodiment of the present invention.
The flow chart of the method for the real-time Measure blood pressure that Fig. 4 provides for the embodiment of the present invention.
The pressure pulse wave signal that the blood pressure real-time measurement apparatus that Fig. 5 provides for the embodiment of the present invention 1 records and photoplethysmographic signal comparison of wave shape figure.
The blood flow rate pulse wave signal that the blood pressure real-time measurement apparatus that Fig. 6 provides for the embodiment of the present invention 2 records and photoplethysmographic signal comparison of wave shape figure.
The pressure pulse wave signal that the blood pressure real-time measurement apparatus that Fig. 7 provides for the embodiment of the present invention 3 records and pressure pulse wave signal waveform comparison diagram.
Main element symbol description
| Blood pressure real-time measurement apparatus | 10 |
| First pulse wave induction module | 12 |
| Second pulse wave induction module | 14 |
| Signal processing module | 16 |
| Analog-to-digital conversion module | 162 |
| Feature point extraction module | 164 |
| Data processing module | 166 |
Following detailed description of the invention will further illustrate the present invention in conjunction with above-mentioned accompanying drawing.
Detailed description of the invention
Below with reference to the blood pressure real-time measurement apparatus that the accompanying drawing detailed description embodiment of the present invention provides.
Refer to Fig. 1, the embodiment of the present invention provides a kind of blood pressure real-time measurement apparatus 10, and this blood pressure real-time measurement apparatus 10 comprises the first pulse wave induction module 12, second pulse wave induction module 14 and signal processing module 16.
Described first pulse wave induction module 12 is for obtaining the first pulse wave signal of each cardiac cycle, and described second pulse wave induction module 14 is for obtaining the second pulse wave signal of each cardiac cycle.Described first pulse wave induction module 12 is different from from the type of the pulse wave that the second pulse wave induction module 14 is responded to measure dissimilar pulse wave.
The type of described pulse wave can comprise pressure pulse wave, photoplethysmographic or blood flow rate pulse wave.Correspondingly, described first pulse wave induction module 12 and the second pulse wave induction module 14 can be the one in pressure pulse wave induction module, photoplethysmographic induction module and blood flow rate pulse wave induction module, as long as the first pulse wave induction module 12 and the second pulse wave induction module 14 choose the mutually different induction apparatus of pulse wave induction type.
Described pressure pulse wave induction module is for sensing the pressure pulse wave of each cardiac cycle.Described pressure pulse wave induction module realizes by pressure transducer.Described pressure transducer comprises at least one in piezoelectric film sensor and silica-based piezoresistance sensor.What described pressure transducer was responded to can change into electric signal transmission to described signal processing module 16 to signal.
Described photoplethysmographic induction module is for sensing the photoplethysmographic of each cardiac cycle.In the light intensity cardiac cycle sense position place tremulous pulse that described photoplethysmographic induction module receives by photo-detector, the volume change of blood changes the optical signal obtained and is converted to the signal of telecommunication through photodetector and obtains described photoplethysmographic in pulsating nature.Described photoplethysmographic induction module can comprise photocell and photodetector.Described photocell can be light emitting diode.Described photodetector can be transmission type photoelectric detector or reflection photo-electric detector, can determine according to selected measuring position.Preferably, reflection photo-electric detector is adopted to detect the optical signal of reflection,arterial.The operating wavelength range of described photocell and photodetector can be the infrared region of 600nm to 1000nm.Preferably, the operating wavelength range of described photocell and photo-detector is 800nm to 960nm.
Described blood flow rate pulse wave induction module is for sensing the blood flow rate pulse wave of each cardiac cycle.Described blood flow rate pulse wave induction module can for magnetic sensing blood Flow Velocity pulse wave induction module or other can measure the induction apparatus of the blood flow rate pulse wave of each cardiac cycle.Preferably, described blood flow rate pulse wave induction module adopts magnetic sensing blood Flow Velocity pulse wave induction module.Described magnetic sensing blood Flow Velocity pulse wave induction module can comprise biased magnetic sheet and Magnetic Sensor.Described biased magnetic sheet is arranged at artery position, and for generation of bias magnetic field, the change that described Magnetic Sensor senses the blood flow rate of each cardiac cycle causes the signal of sense position place changes of magnetic field.Described induced signal changes into electric signal transmission to described signal processing module 16.Described Magnetic Sensor can be giant magneto-resistance sensor, tunnel magneto-resistive sensor or Hall magnetic sensor.
Above-mentioned pulse wave induction module provides required running voltage by control circuit to it.
Described in first embodiment of the invention, the first pulse wave induction module 12 is pressure pulse wave induction module, and described second pulse wave induction module 14 is photoplethysmographic induction module.Described in second embodiment of the invention, the first pulse wave induction module 12 is blood flow rate pulse wave induction module, and described second pulse wave induction module 14 is photoplethysmographic induction module.Described in third embodiment of the invention, the first pulse wave induction module 12 is pressure pulse wave induction module, and described second pulse wave induction module 14 is blood flow rate pulse wave induction module.
Described first pulse wave induction module 12 and the second pulse wave induction module 14 can be arranged at the artery position of human body.Preferably, can be arranged at radial artery, carotid artery or other press close to the artery position of body surface.More preferably, described first pulse wave induction module 12 and the second pulse wave induction module 14 are arranged on radial artery.Described first pulse wave induction module 12 and the second pulse wave induction module 14 can obtain the dissimilar pulse wave of same artery position simultaneously.For realizing this purpose, described first pulse wave induction module 12 and the second pulse wave induction module 14 can be arranged at described same artery position place, or described first pulse wave induction module 12 and the second pulse wave induction module 14 at least adjacent to one another and arrange near described same artery position, and described first pulse wave induction module 12 and the second pulse wave induction module 14 at the line of this tremulous pulse setting position by described same artery position and perpendicular to the direction of blood flow, substantially identical to ensure that signal that heart transmits arrives the distance of two pulse wave induction modules.
By arranging the dissimilar pulse wave signal that two kinds of different pulse wave induction modules measure described same position place at same artery position or the position vertical from blood flow direction simultaneously, because dissimilar pulse wave transmission speed is different from the relation of blood pressure, for the blood pressure determined, there is the transmission time difference determined in two kinds of dissimilar pulse waves.In other words, there is the corresponding relation determined in two kinds of dissimilar pulse wave transmission time differences and blood pressure.Thus namely the pulse wave transmission time difference measuring two types of same artery position by arranging two kinds of dissimilar pulse wave induction modules can obtain arteriotony simultaneously.
In addition, described blood pressure real-time measurement apparatus 10 also can comprise two or more dissimilar pulse wave induction modules further, to obtain more accurate pressure value in real time.
Described signal processing module 16 receives the first pulse wave signal and second pulse wave signal of described first pulse wave induction module 12 and the transmission of the second pulse wave induction module 14, and same artery position can be obtained and transmission time difference between described first pulse wave signal simultaneously received and the second pulse wave signal, and the arteriotony of each cardiac cycle can be obtained according to this transmission time difference.
Refer to Fig. 2, described signal processing module 16 can comprise analog-to-digital conversion module 162, feature point extraction module 164 and data processing module 166.
The first pulse wave signal received and the second pulse wave signal can be carried out analog digital conversion by described analog-to-digital conversion module 162, thus convert the first pulse wave digital signal and the second pulse wave digital signal to.Described analog-to-digital conversion module 162 can adopt analog-digital converter to realize.
Described signal processing module 16 can comprise a filtering and signal amplification module further, for first carrying out filtering and signal amplification to the first pulse wave signal received and the second pulse wave signal, and then carries out analog digital conversion.Described filtering and signal amplification module can adopt filter circuit and signal amplifier to realize.
Each cardiac cycle comprises relaxing period and systole.Described feature point extraction module 164 is for extracting pulse wave digital signal in each cardiac cycle in relaxing period and Syst characteristic point.Particularly, described feature point extraction module 164 is for extracting the first pulse wave digital signal of each cardiac cycle and the second pulse wave digital signal respectively in relaxing period and Syst characteristic point.Described characteristic point can comprise the bottom signal point of the crest of pulse wave signal, trough or crest trailing edge, specifically can determine according to the different corresponding relations of different types of pulse wave signal from Ventricular systole and relaxing period.
Choosing for the transmission time difference of reflection two kinds of pulse waves in each cardiac cycle of described characteristic point.Described transmission time difference comprises systolic pulse ripple transmission time difference (PTTS) and the relaxing period pulse wave transmission time difference (PTTD) of each cardiac cycle.Preferably, when described first pulse wave induction module 12 is blood flow rate pulse wave induction module, when second pulse wave induction module 14 is photoplethysmographic induction module, for reflecting that the characteristic point of systolic pulse ripple transmission time difference can be the first wave peak dot of two kinds of pulse waves, for reflecting that the characteristic point of the pulse wave transmission time difference of relaxing period is the first wave valley point of two kinds of pulse waves.When described first pulse wave induction module 12 is blood flow rate pulse wave induction module, when second pulse wave induction module 14 is pressure pulse wave induction module, for reflecting that the characteristic point of systolic pulse ripple transmission time difference can be the first wave peak dot of two kinds of pulse waves, for reflecting that the characteristic point of the pulse wave transmission time difference of relaxing period is two kinds of pulse wave Second Wave peak dots.When described first pulse wave induction module 12 is photoplethysmographic induction module, when second pulse wave induction module 14 is pressure pulse wave induction module, for reflecting that the characteristic point of systolic pulse ripple transmission time difference is the first wave peak dot of two kinds of pulse waves, for reflecting that the characteristic point of the pulse wave transmission time difference of relaxing period is bottom two kinds of pulse wave secondary peak trailing edges.
Described data processing module 166 can be used to calculate same artery position and transmission time difference between described first pulse wave signal simultaneously obtained and the second pulse wave signal.This transmission time difference can be described same artery position and belongs to the pulse wave transmission time difference between the first pulse wave digital signal of same cardiac cycle and the second pulse wave digital signal character pair point.Described systolic pulse ripple transmission time difference can be the first pulse wave digital signal and the second pulse wave digital signal interval at the systole character pair point of same cardiac cycle.Described relaxing period pulse wave transmission time difference can be the first pulse wave digital signal and the second pulse wave digital signal interval at the relaxing period characteristic of correspondence point of same cardiac cycle.Described data processing module 166 can obtain the pressure value of each cardiac cycle further according to the pulse wave transmission time difference of each cardiac cycle.Particularly, described data processing module 166 can obtain systolic pressure and the diastolic pressure of each cardiac cycle according to the systolic pulse ripple transmission time difference of each cardiac cycle and relaxing period pulse wave transmission time difference.
Described pressure value and the inversely proportional relation of described transmission time difference.Preferably, described pressure value becomes inverse square example relation with described transmission time difference.The pass of transmission time difference described in the embodiment of the present invention and blood pressure is:
Systolic pressure=
; (1)
Diastolic pressure=
(2)
Wherein, ρ is blood flow density, A and B is calibration parameter, can for the constant determined within short-term for the human body determined.
Described data processing module 166 comprises a demarcating module further, and this demarcating module is used for determining described calibration parameter A and B.This demarcating module can perform a calibrating procedure, and this calibrating procedure comprises: first utilize the blood pressure measuring method of standard to somatometry to be measured calibration systolic pressure P
swith calibration diastolic pressure P
d; And record pulse wave transmission time difference PTTS and PTTD of systole and the relaxing period simultaneously recorded; And systolic pressure P will be calibrated
swith calibration diastolic pressure P
dand pulse wave transmission time difference PTTS and PTTD recorded substitutes into respectively in described formula (1) and (2) and calculates described calibration parameter A and B simultaneously.The blood pressure measuring method of described standard can obtain for utilizing the mercurial sphygmomanometer of standard to measure.This calibration process is simple to operate, convenient and can improve the accuracy of blood pressure measurement.
Described feature point extraction module 164 and data processing module 166 can adopt a processor to realize.
Described blood pressure real-time measurement apparatus 10 can comprise a display module further, the pressure value obtained with display measurement in real time or pressure value curve.
Described blood pressure real-time measurement apparatus 10 can comprise a transport module further, for the real-time pressure value recorded is transferred to an intelligent terminal with further research and application.
Described transport module can be preferably wireless transport module.The transmission means that described wireless transport module adopts can be at least one in Bluetooth transmission, infrared transmission and radio frequency transmission.Described intelligent terminal can be that a monitoring device is used for the pressure value that Real-Time Monitoring measures.In addition, described intelligent terminal also can receive described pulse wave transmission time difference by described transport module, and calculates systolic pressure and the diastolic pressure of each cardiac cycle by this intelligent terminal.
Described first pulse wave induction module 12, second pulse wave induction module 14, signal processing module 16, transport module even display module accessible site are arranged.Described integrated arrange can for by described first pulse wave induction module 12, second pulse wave induction module 14, signal processing module 16, transport module even display module be integrated on a printed circuit board.This printed circuit board is preferably flexible printed circuit board, thus makes this blood pressure real-time measurement apparatus 10 can be a flexible apparatus.
Described blood pressure real-time measurement apparatus 10 can comprise a body further, described first pulse wave induction module 12, second pulse wave induction module 14, signal processing module 16 is encapsulated wherein.In addition, preferably, described body can be easy to described blood pressure real-time measurement apparatus 10 to be fixed on artery position.Preferably, described body can be a Wearable structure.Refer to Fig. 3, in the embodiment of the present invention, described encapsulating structure is the wrist strap of a flexibility.During use, this wrist strap can be fixed on tremulous pulse (as wrist radial artery) surface, and make the sensitive surface of described first pulse wave induction module 12 and the second pulse wave induction module 14 sense pulse wave signal in real time towards skin side.In addition, described body also can be a SMD structure, for described blood pressure real-time measurement apparatus 10 is attached at artery surface.
Refer to Fig. 4, the embodiment of the present invention provides a kind of method utilizing the real-time Measure blood pressure of above-mentioned blood pressure real-time measurement apparatus 10 further, comprises the following steps:
S1, obtains described first pulse wave signal of each cardiac cycle;
S2, obtain described second pulse wave signal of each cardiac cycle, described first pulse wave signal is different from the pulse wave type of the second pulse wave signal;
S3, obtains same artery position and transmission time difference between described first pulse wave signal simultaneously obtained and the second pulse wave signal; And
S4, obtains the arteriotony of this cardiac cycle according to this transmission time difference.
In the method, the obtain manner of described transmission time difference and the corresponding relation between blood pressure and transmission time difference are introduced all, do not repeat them here.
The pulse wave transmission time difference of the blood pressure real-time measurement apparatus 10 that the embodiment of the present invention provides by adopting the different pulse wave induction module of two kinds of pulse waves induction type to respond to same artery position simultaneously, and according to the pressure value of each cardiac cycle of pulse wave transmission time difference Real-time Obtaining.This blood pressure real-time measurement apparatus 10 first does not need to measure electrocardiosignal, does not therefore need the lead-in wire of electrocardioelectrode, measures in real time bring great convenience to blood pressure.Second, two kinds of dissimilar pulse wave signals take from tremulous pulse same position, thus the accuracy that blood pressure is measured in real time is high, and the 3rd, the measuring position of two kinds of pulse waves can be chosen according to the practical situation of patient, and the practical application for device provides very large motility.Such as, the individuals with disabilities losing both arms can measure at carotid artery place.
Embodiment 1
Described blood pressure real-time measurement apparatus 10 comprises the first pulse wave induction module 12, second pulse wave induction module 14, signal processing module 16 and wireless transport module.Described first pulse wave induction module 12, second pulse wave induction module 14, signal processing module 16 and wireless transport module is integrated is arranged at a flexible PCB and forms a wrist strap, for measuring wrist radial artery pressure value in real time.Wherein, described first pulse wave induction module 12 is pressure pulse wave induction module, and the second pulse wave induction module 14 is photoplethysmographic induction module.
Refer to Fig. 5, Fig. 5 is the pressure pulse wave signal and photoplethysmographic signal that record.Upper waveform is pressure pulse wave, and lower waveform is photoplethysmographic.Wherein, at some cardiac cycles, systolic pulse ripple transmission time difference PTTS is above-mentioned two kinds of peak-to-peak intervals of pulse wave first wave (two solid line interval), relaxing period pulse wave transmission time difference PTTD be bottom above-mentioned two kinds of pulse wave secondary peak trailing edges between interval (two chain-dotted line interval).After testing, PTTS is 32ms, PTTD is 50ms.Calibration parameter A=0.115, B=0.18, calculating the blood pressure obtaining this cardiac cycle is 118/77mmHg.
Embodiment 2
The blood pressure real-time measurement apparatus of this embodiment is substantially identical with the blood pressure real-time measurement apparatus of embodiment 1, difference is, in the present embodiment, described first pulse wave induction module 12 is blood flow rate pulse wave induction module, and the second pulse wave induction module 14 is photoplethysmographic induction module.
Refer to Fig. 6, Fig. 6 is the blood flow rate pulse wave signal and photoplethysmographic signal that record.Upper waveform is blood flow rate pulse wave, and lower waveform is photoplethysmographic.Wherein, at some cardiac cycles, systolic pulse ripple transmission time difference PTTS is above-mentioned two kinds of peak-to-peak intervals of pulse wave first wave (two solid line interval), and relaxing period pulse wave transmission time difference PTTD is the interval (two chain-dotted line interval) between above-mentioned two kinds of pulse wave first troughs.After testing, PTTS is 30ms, PTTD is 47ms.Calibration parameter A=0.09, B=0.13, calculating the blood pressure obtaining this cardiac cycle is 104/62mmHg.
Embodiment 3
The blood pressure real-time measurement apparatus of this embodiment is substantially identical with the blood pressure real-time measurement apparatus of embodiment 1, difference is, in the present embodiment, described first pulse wave induction module 12 is blood flow rate pulse wave induction module, and the second pulse wave induction module 14 is pressure pulse wave induction module.
Refer to Fig. 7, Fig. 7 is the blood flow rate pulse wave signal and pressure pulse wave signal that record.Upper waveform is blood flow rate pulse wave, and lower waveform is pressure pulse wave.Wherein, at some cardiac cycles, systolic pulse ripple transmission time difference PTTS is above-mentioned two kinds of peak-to-peak intervals of pulse wave first wave (two solid line interval), and relaxing period pulse wave transmission time difference PTTD is above-mentioned two kinds of peak-to-peak intervals of pulse wave Second Wave (two chain-dotted line interval).After testing, PTTS is 36ms, PTTD is 47ms.Calibration parameter A=0.136, B=0.17, calculating the blood pressure obtaining this cardiac cycle is 111/78mmHg.
In addition, those skilled in the art can also do other change in spirit of the present invention, and certainly, these changes done according to the present invention's spirit, all should be included within the present invention's scope required for protection.
Claims (9)
1. a blood pressure real-time measurement apparatus, is characterized in that, comprising:
First pulse wave induction module, for obtaining the first pulse wave signal of each cardiac cycle;
Second pulse wave induction module, for obtaining the second pulse wave signal of each cardiac cycle, wherein said first pulse wave induction module is different from the type of the pulse wave that described second pulse wave induction module obtains, wherein, described first pulse wave induction module is pressure pulse wave induction apparatus, and described second pulse wave induction module is photoplethysmographic induction apparatus; And
Signal processing module, for obtaining described first pulse wave signal and second pulse wave signal of same artery position simultaneously, and calculate the transmission time difference between described first pulse wave signal and the second pulse wave signal that this same artery position obtains simultaneously, and obtain the arteriotony of each cardiac cycle according to this transmission time difference.
2. blood pressure real-time measurement apparatus as claimed in claim 1, it is characterized in that, described first pulse wave induction module and described second pulse wave induction module are arranged at described same artery position, or the line of described first pulse wave induction module and described second pulse wave induction module setting position is perpendicular to the direction of blood flow.
3. blood pressure real-time measurement apparatus as claimed in claim 1, it is characterized in that, described signal processing module comprises:
Analog-to-digital conversion module, carries out analog digital conversion respectively for the first pulse wave signal of being obtained at described same artery position place and the second pulse wave signal simultaneously, obtains the first pulse wave digital signal and the second pulse wave digital signal;
Feature point extraction module, for extracting the first pulse wave digital signal and the second pulse wave digital signal characteristic of correspondence point of same cardiac cycle respectively; And
Data processing module, for obtaining same artery position and belonging to the transmission time difference between the first pulse wave digital signal of same cardiac cycle and the second pulse wave digital signal character pair point, and calculate the pressure value of each cardiac cycle according to this transmission time difference.
4. blood pressure real-time measurement apparatus as claimed in claim 3, it is characterized in that, described transmission time difference comprises systole transmission time difference and relaxing period transmission time difference; Described pressure value comprises systolic pressure and diastolic pressure, and the acquisition formula of described systolic pressure and diastolic pressure is:
Wherein, ρ is blood flow density, A and B is calibration parameter, and PTTS is systole transmission time difference, and PTTD is relaxing period transmission time difference.
5. blood pressure real-time measurement apparatus as claimed in claim 4, it is characterized in that, described signal processing module comprises a demarcating module further, and this demarcating module is used for determining described calibration parameter A and B, and this demarcating module comprises calibrating procedure, and this calibration process is:
Utilize the blood pressure measuring method of standard to somatometry to be measured calibration systolic pressure (P
s) and calibration diastolic pressure (P
d);
And record the described systole transmission time difference and relaxing period transmission time difference that record simultaneously; And
By described calibration systolic pressure (P
s) and calibration diastolic pressure (P
d) and the systole transmission time difference that simultaneously records and relaxing period transmission time difference substitute into respectively in described formula and calculate described calibration parameter A and B.
6. blood pressure real-time measurement apparatus as claimed in claim 1, it is characterized in that, comprise a transport module further, for transmitting the pressure value that records to an intelligent terminal so that research and application further, described transport module is wireless transport module, and the mode of this wireless transport module transmission comprises at least one in Bluetooth transmission, infrared transmission and radio frequency transmission.
7. blood pressure real-time measurement apparatus as claimed in claim 1, it is characterized in that, comprise a body further, described first pulse wave induction module, the second pulse wave induction module and the integrated setting of signal processing module are also arranged in this body, this body makes blood pressure real-time measurement apparatus be arranged on artery position in the mode of Wearable, and the sensitive surface of the first pulse wave induction module and the second pulse wave induction module described in this is towards the skin of described artery position.
8. blood pressure real-time measurement apparatus as claimed in claim 1, it is characterized in that, described transmission time difference comprises systolic pulse ripple transmission time difference and relaxing period pulse wave transmission time difference, described systolic pulse ripple transmission time difference is same artery position and belongs to the interval between the first wave peak dot of two kinds of pulse waves of same cardiac cycle, and described relaxing period pulse wave transmission time difference is same artery position and interval between belonging to bottom two kinds of pulse wave secondary peak trailing edges of same cardiac cycle.
9. measure a method for pulse wave transmission time difference in real time, comprise the following steps:
Obtain the first pulse wave signal of each cardiac cycle;
Obtain the second pulse wave signal of each cardiac cycle, described first pulse wave signal is different from the pulse wave type of the second pulse wave signal, and wherein said first pulse wave signal is pressure pulse wave, and described second pulse wave signal is photoplethysmographic; And
Calculate the transmission time difference of described first pulse wave signal that same artery position obtains simultaneously and the second pulse wave signal.
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