CN103431930A - Methyl ester resin-containing vaginal mold - Google Patents
Methyl ester resin-containing vaginal mold Download PDFInfo
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- CN103431930A CN103431930A CN2013103332004A CN201310333200A CN103431930A CN 103431930 A CN103431930 A CN 103431930A CN 2013103332004 A CN2013103332004 A CN 2013103332004A CN 201310333200 A CN201310333200 A CN 201310333200A CN 103431930 A CN103431930 A CN 103431930A
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- polymethyl methacrylate
- vagina
- estradiol
- methacrylate resin
- methyl ester
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Abstract
The invention relates to a methyl ester resin-containing vaginal mold, which consists of a polymethyl methacrylate resin and estradiol, wherein the weight ratio of the polymethyl methacrylate resin to the estradiol is 20:(5-8). The methyl ester resin-containing vaginal mold has the advantages that the vaginal mold contains an estrogen, so that the contracture rate of an artificial vagina is greatly lowered; the vaginal mold with estrogen sustained-releasing capability is prepared by combining the polymethyl methacrylate resin with the estrogen, so that vaginal mold treatment and estrogen treatment are effectively integrated; therefore, the vaginal mold with the sustained-releasing capability has huge potential to clinical application in future.
Description
Technical field
The present invention relates to a kind of vaginal stent, specifically, is the vaginal stent that contains the methyl ester resin about a kind of.
Background technology
The congenital absence of vagina patient is mostly Rokitansky-Kuster-Hauser syndrome (RKH syndrome), is the undergrown result of embryo's bilateral in period gyneduct, and karyotype is 46XX.Congenital absence of vagina patient's treatment has operative treatment and non-operative treatment.Operative treatment comprises vulvovaginoplasty (Williams method), make dibbling pico farad (McIndol method), peritoneum is for vagina method (Rothman method), Sigmoid Colon vagina method (Pratl method), amniotic membrane is rebuild vagina etc. for vagina method and novel biomaterial, and the application of vaginal stent is the very important ring of vaginoplasty post processing.Postoperatively need to place vaginal stent March to half a year, prevent the contracture of artificial vagina.For vaginal vestibule section mucosa good springiness, the table shallow depression person of existence is arranged, can adopt Frank method vagina top to press non-operative treatment.Frank proposed pole compression method non-operative treatment congenital absence of vagina in 1938, adopt the vaginal vestibule section of the pole aligning locking of different-diameter, along normal vagina direction of principal axis top, pressed, and with dilating urethra rectum gap, finally formed artificial tract.
Chinese patent application CN101352360A discloses a kind of soft bearing band with side opening reconstruction vaginal mold, comprises a body, and this body is provided with several apertures, and an end of body is the Duckbill type cecum, and another end is opening.Chinese patent application CN202078425U discloses the modified form vaginal stent, comprises cylindrical main part, and the front end of described main part is one-body molded has a taper section, the rear end of described main part to offer axial and finger-hole finger size coupling.
But, about can either greatly reducing the contracture rate of artificial vagina, the vaginal stent that can discharge again estrogenic methyl ester resin yet there are no report.
Summary of the invention
The objective of the invention is for deficiency of the prior art, a kind of contracture rate that can either greatly reduce artificial vagina is provided, can discharge estrogenic vaginal stent again.
One purpose more of the present invention is that a kind of new purposes of vaginal stent is provided.
For achieving the above object, the technical scheme that the present invention takes is: a kind of vaginal stent that contains the methyl ester resin, by polymethyl methacrylate resin, estradiol, formed, described polymethyl methacrylate resin, estradiol weight ratio are 20:(5-8).
Described polymethyl methacrylate resin, estradiol weight ratio are 4:1.
For realizing above-mentioned second purpose, the technical scheme that the present invention takes is: the application of vaginal stent in the slow-release medicine of the artificial vagina of preparation treatment.
The invention has the advantages that: contain the contracture rate that estrogenic vaginal stent reduces artificial vagina greatly.The present invention, by the polymethyl methacrylate resin material is combined with estrogen, prepares the vaginal stent with estrogen slow-release capability, thereby the treatment of the treatment of vaginal stent and these two aspects of estrin treatment is united effectively.Therefore, this vaginal stent with slow-release function has very large potentiality in clinical practice afterwards.
The accompanying drawing explanation
Accompanying drawing 1 is the vaginal stent structural representation that contains medicine.
Accompanying drawing 2 is the vaginal stent structural representations that do not contain medicine.
The specific embodiment
Below in conjunction with accompanying drawing, the specific embodiment provided by the invention is elaborated.
Embodiment 1
One, medicine and preparation:
1, estrogen: estradiol crude drug.
2, the polymethyl methacrylate resin sizing material.
Two, equipment
Pressure forming machine (product type: XLB-D400-400), rubber mixing machine (model: JTC-752A), electronic platform scale (model: TSC-6) electric drying oven with forced convection (model: 101A-1B), drying baker (model: the 101-3 type), three-roll grinder (model: the SG-150 type), Weighing display device (model: XK3130).
Three, the material preparation
Take polymethyl methacrylate resin sizing material 100g, take estradiol 25g.
Two kinds of raw materials are put into to the rubber mixing machine blend, make sizing material and medicine mixing even, draw thin-pass 10 times, medicine more is evenly dispersed in sizing material.
Four, the vaginal stent preparation:
Take the 10g material, put into the mould mold pressing; 140 ℃ of temperature, time 12min, pressure 9.5MPa depanning; Take out product, deburring; Encapsulation, standby after the ethylene oxide gas sterilization.The finished product made is dispersed in equally distributed tiny estradiol drug particles (seeing Fig. 1) as seen.
Embodiment 2
One, medicine and preparation: with embodiment 1.
Two, equipment: with embodiment 1.
Three, material preparation: take polymethyl methacrylate resin sizing material 100g, take estradiol 30g, the other the same as in Example 1.
Four, vaginal stent preparation: with embodiment 1.
Embodiment 3
One, medicine and preparation: with embodiment 1.
Two, equipment: with embodiment 1.
Three, material preparation: take polymethyl methacrylate resin sizing material 100g, take estradiol 50g, the other the same as in Example 1.
Four, vaginal stent preparation: with embodiment 1.
Embodiment 4
One, medicine and preparation: with embodiment 1.
Two, equipment: with embodiment 1.
Three, material preparation: take polymethyl methacrylate resin sizing material 100g, take estradiol 40g, the other the same as in Example 1.
Four, vaginal stent preparation: with embodiment 1.
Embodiment 5
One, preparation:
1, the polymethyl methacrylate resin sizing material.
Two, equipment
Pressure forming machine (product type: XLB-D400-400), rubber mixing machine (model: JTC-752A), electronic platform scale (model: TSC-6) electric drying oven with forced convection (model: 101A-1B), drying baker (model: the 101-3 type), three-roll grinder (model: the SG-150 type), Weighing display device (model: XK3130).
Three, material is prepared
Take polymethyl methacrylate resin sizing material 100g.
Four, the vaginal stent preparation:
Take the 10g material, put into the mould mold pressing; 140 ℃ of temperature, time 12min, pressure 9.5MPa depanning; Take out product, deburring; Encapsulation, standby after the ethylene oxide gas sterilization.The finished product made is shown in Fig. 2.
Embodiment 6
Laboratory animal is set up model
Laboratory animal absence of vagina model preparation method, rebuild experiment and the clinical research thesis for the doctorate of vagina and set up model according to the obstetrics and gynecology Zhou Huimei of the China Concord Medical Science University organizational project medical bio sticking patch of 2008
One, laboratory animal adopts 12 of Chinese Small-sized pigs, male and female, and the 4-6 monthly age, sexual maturity, unpregnancy does not produce, the about 25kg of body weight.
Two, Animal Anesthesia and preparation
Three, the full vagina resection of Chinese Small-sized pig causes the absence of vagina model.
Embodiment 7
By embodiment
6after the laboratory animal be successfully established is had a rest 1 week, more capable vagina anaplasty.12 Chinese miniature pig groupings after the vagina anaplasty are grouped as follows:
Group 1: 4 Chinese miniature pigs after the vagina anaplasty (group 1-1 pig, group 1-2 pig, group 1-3 pig, group 1-4 pig).
Group 2: after the vagina anaplasty, the vaginal stent that embodiment 5 is obtained is positioned over (group 2-1 pig, group 2-2 pig, group 2-3 pig, pig group 2-4 pig) in cave, artificial vagina chamber.
Group 3: after the vagina anaplasty, the vaginal stent that embodiment 1 is obtained is positioned over (group 3-1 pig, group 3-2 pig, group 3-3 pig, group 3-4 pig) in cave, artificial vagina chamber.
Vagina ultrastructure by pig after the above-mentioned vagina anaplasty of electron microscopic observation, the results are shown in Table 1
Table 1: the vagina anaplasty is each pig vagina contracture situation (each pig vagina contracture area accounts for the percentage ratio of artificial vagina area) after two weeks
| ? | No. 1 pig | No. 2 pigs | No. 3 pigs | No. 4 pigs |
| Group 1 | 50% | 55% | 52% | 50% |
| Group 2 | 12% | 10% | 11% | 13% |
| Group 3 | 5% | 7% | 4% | 3% |
Do not place vaginal stent after vaginoplasty, the contracture rate of artificial vagina is very high; Place vaginal stent after vaginoplasty, can reduce the contracture rate of artificial vagina; Contain the contracture rate that estrogenic vaginal stent reduces artificial vagina greatly.
The present invention, by the polymethyl methacrylate resin material is combined with estrogen, prepares the vaginal stent with estrogen slow-release capability, thereby the treatment of the treatment of vaginal stent and these two aspects of estrin treatment is united effectively.Therefore, this vaginal stent with slow-release function has very large potentiality in clinical practice afterwards.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the inventive method; can also make some improvement and supplement, these improvement and supplement and also should be considered as protection scope of the present invention.
Claims (4)
1. the application of the vaginal stent that contains the methyl ester resin in the slow-release medicine of the artificial vagina of preparation treatment, the described vaginal stent that contains the methyl ester resin, polymethyl methacrylate resin, estradiol, consist of, described polymethyl methacrylate resin, estradiol weight ratio are 20:(5-8).
2. application according to claim 1, described polymethyl methacrylate resin, estradiol weight ratio are 4:1.
3. a vaginal stent that contains the methyl ester resin, be comprised of polymethyl methacrylate resin, estradiol, it is characterized in that, described polymethyl methacrylate resin, estradiol weight ratio are 20:(5-8).
4. vaginal stent according to claim 3, is characterized in that, described polymethyl methacrylate resin, estradiol weight ratio are 4:1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013103332004A CN103431930A (en) | 2013-08-02 | 2013-08-02 | Methyl ester resin-containing vaginal mold |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013103332004A CN103431930A (en) | 2013-08-02 | 2013-08-02 | Methyl ester resin-containing vaginal mold |
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| CN103431930A true CN103431930A (en) | 2013-12-11 |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1548013A (en) * | 2003-05-14 | 2004-11-24 | 上海市计划生育科学研究所 | Simple vaginal ring making process |
| WO2004100874A2 (en) * | 2003-05-07 | 2004-11-25 | Merck & Co., Inc. | Androgen receptor modulators and methods of use thereof |
| CN101152102A (en) * | 2007-09-13 | 2008-04-02 | 李风 | Cunt shaping expanding device |
| CN201131825Y (en) * | 2007-09-13 | 2008-10-15 | 李风 | Vagina shaping dilator |
| CN101351188A (en) * | 2005-08-12 | 2009-01-21 | 药物技术公司 | Estrogen compositions and therapeutic methods of use thereof |
| CN102098991A (en) * | 2008-02-04 | 2011-06-15 | 特卫华妇女健康有限公司 | Monolithic intravaginal rings comprising progesterone and methods of making and uses thereof |
-
2013
- 2013-08-02 CN CN2013103332004A patent/CN103431930A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004100874A2 (en) * | 2003-05-07 | 2004-11-25 | Merck & Co., Inc. | Androgen receptor modulators and methods of use thereof |
| CN1548013A (en) * | 2003-05-14 | 2004-11-24 | 上海市计划生育科学研究所 | Simple vaginal ring making process |
| CN101351188A (en) * | 2005-08-12 | 2009-01-21 | 药物技术公司 | Estrogen compositions and therapeutic methods of use thereof |
| CN101152102A (en) * | 2007-09-13 | 2008-04-02 | 李风 | Cunt shaping expanding device |
| CN201131825Y (en) * | 2007-09-13 | 2008-10-15 | 李风 | Vagina shaping dilator |
| CN102098991A (en) * | 2008-02-04 | 2011-06-15 | 特卫华妇女健康有限公司 | Monolithic intravaginal rings comprising progesterone and methods of making and uses thereof |
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Application publication date: 20131211 |