CN103405810A - Vagina mold containing methyl methacrylate resin - Google Patents
Vagina mold containing methyl methacrylate resin Download PDFInfo
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- CN103405810A CN103405810A CN2013103333810A CN201310333381A CN103405810A CN 103405810 A CN103405810 A CN 103405810A CN 2013103333810 A CN2013103333810 A CN 2013103333810A CN 201310333381 A CN201310333381 A CN 201310333381A CN 103405810 A CN103405810 A CN 103405810A
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- vagina
- methacrylate resin
- polymethyl methacrylate
- estriol
- methyl methacrylate
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Abstract
The invention relates to a vagina mold containing methyl methacrylate resin. The vagina mold is formed by the methyl methacrylate resin and estriol which are 20:(5-8) in weight ratio. The invention has the advantage that the vagina mold containing estrogen greatly lowers the contracture rate of an artificial vagina. According to the invention, the material methyl methacrylate resin is combined with the estrogen to prepare the vagina mold with the ability to slowly release the estrogen, so that vagina mold treatment and estrogen treatment are effectively consolidated. Therefore, the vagina mold with a slow release function has great clinical application potential in the further.
Description
Technical field
The present invention relates to a kind of vaginal stent, specifically, is the vaginal stent that contains polymethyl methacrylate resin about a kind of.
Background technology
The congenital absence of vagina patient is mostly Rokitansky-Kuster-Hauser syndrome (RKH syndrome), is the undergrown result of embryo's bilateral in period gyneduct, and karyotype is 46XX.Congenital absence of vagina patient's treatment has operative treatment and non-operative treatment.Operative treatment comprises vulvovaginoplasty (Williams method), make dibbling pico farad (McIndol method), peritoneum is for vagina method (Rothman method), Sigmoid Colon vagina method (Pratl method), amniotic membrane is rebuild vagina etc. for vagina method and novel biomaterial, and the application of vaginal stent is the very important ring of vaginoplasty post processing.Postoperatively need to place vaginal stent March to half a year, prevent the contracture of artificial vagina.For vaginal vestibule section mucosa good springiness, the table shallow depression person of existence is arranged, can adopt Frank method vagina top to press non-operative treatment.Frank proposed pole compression method non-operative treatment congenital absence of vagina in 1938, adopt the vaginal vestibule section of the pole aligning locking of different-diameter, pressed along normal vagina direction of principal axis top, with dilating urethra rectum gap, finally formed artificial tract.
Chinese patent application CN101352360A discloses a kind of soft bearing band with side opening reconstruction vaginal mold, comprises a body, and this body is provided with several apertures, and an end of body is the Duckbill type cecum, and another end is opening.Chinese patent application CN202078425U discloses the modified form vaginal stent, comprises cylindrical main part, and the front end of described main part is one-body molded has a taper section, the rear end of described main part to offer axial and finger-hole finger size coupling.
But, about can either greatly reducing the contracture rate of artificial vagina, can discharge again estrogenic vaginal stent and yet there are no report.
Summary of the invention
The objective of the invention is for deficiency of the prior art, a kind of contracture rate that can either greatly reduce artificial vagina is provided, can discharge estrogenic vaginal stent again.
One purpose more of the present invention is that a kind of new purposes of vaginal stent is provided.
For achieving the above object, the technical scheme that the present invention takes is: a kind of vaginal stent that contains polymethyl methacrylate resin, polymethyl methacrylate resin, estriol, consist of, described polymethyl methacrylate resin, estriol weight ratio are 20:(5-8).
Described polymethyl methacrylate resin, estriol weight ratio are 4:1.
For realizing above-mentioned second purpose, the technical scheme that the present invention takes is: the application of vaginal stent in the slow-release medicine of the artificial vagina of preparation treatment.
The invention has the advantages that: contain the contracture rate that estrogenic vaginal stent reduces artificial vagina greatly.The present invention, by the polymethyl methacrylate resin material is combined with estrogen, prepares the vaginal stent with estrogen slow-release capability, thereby the treatment of the treatment of vaginal stent and these two aspects of estrin treatment is united effectively.Therefore, this vaginal stent with slow-release function has very large potentiality in clinical practice afterwards.
The accompanying drawing explanation
Accompanying drawing 1 is the vaginal stent structural representation that contains medicine.
Accompanying drawing 2 is the vaginal stent structural representations that do not contain medicine.
The specific embodiment
Below in conjunction with accompanying drawing, the specific embodiment provided by the invention is elaborated.
Embodiment 1
One, medicine and preparation:
1, estrogen: estriol crude drug.
2, the polymethyl methacrylate resin sizing material.
Two, equipment
Pressure forming machine (product type: XLB-D400-400), rubber mixing machine (model: JTC-752A), electronic platform scale (model: TSC-6) electric drying oven with forced convection (model: 101A-1B), drying baker (model: the 101-3 type), three-roll grinder (model: the SG-150 type), Weighing display device (model: XK3130).
Three, the material preparation
Take polymethyl methacrylate resin sizing material 100g, take estriol 25g.
Two kinds of raw materials are put into to the rubber mixing machine blend, make sizing material and medicine mixing even, draw thin-pass 10 times, medicine more is evenly dispersed in sizing material.
Four, the vaginal stent preparation:
Take the 10g material, put into the mould mold pressing; 140 ℃ of temperature, time 12min, pressure 9.5MPa depanning; Take out product, deburring; Encapsulation, standby after the ethylene oxide gas sterilization.The finished product made is dispersed in equally distributed tiny estriol drug particles (seeing Fig. 1) as seen.
Embodiment 2
One, medicine and preparation: with embodiment 1.
Two, equipment: with embodiment 1.
Three, material preparation: take polymethyl methacrylate resin sizing material 100g, take estriol 30g, the other the same as in Example 1.
Four, vaginal stent preparation: with embodiment 1.
Embodiment 3
One, medicine and preparation: with embodiment 1.
Two, equipment: with embodiment 1.
Three, material preparation: take polymethyl methacrylate resin sizing material 100g, take estriol 50g, the other the same as in Example 1.
Four, vaginal stent preparation: with embodiment 1.
Embodiment 4
One, medicine and preparation: with embodiment 1.
Two, equipment: with embodiment 1.
Three, material preparation: take polymethyl methacrylate resin sizing material 100g, take estriol 40g, the other the same as in Example 1.
Four, vaginal stent preparation: with embodiment 1.
Embodiment 5
One, preparation:
1, the polymethyl methacrylate resin sizing material.
Two, equipment
Pressure forming machine (product type: XLB-D400-400), rubber mixing machine (model: JTC-752A), electronic platform scale (model: TSC-6) electric drying oven with forced convection (model: 101A-1B), drying baker (model: the 101-3 type), three-roll grinder (model: the SG-150 type), Weighing display device (model: XK3130).
Three, material is prepared
Take polymethyl methacrylate resin sizing material 100g.
Four, the vaginal stent preparation:
Take the 10g material, put into the mould mold pressing; 140 ℃ of temperature, time 12min, pressure 9.5MPa depanning; Take out product, deburring; Encapsulation, standby after the ethylene oxide gas sterilization.The finished product made is shown in Fig. 2.
Embodiment 6
Laboratory animal is set up model
Laboratory animal absence of vagina model preparation method, rebuild experiment and the clinical research thesis for the doctorate of vagina and set up model according to the obstetrics and gynecology Zhou Huimei of the China Concord Medical Science University organizational project medical bio sticking patch of 2008
One, laboratory animal adopts 12 of Chinese Small-sized pigs, male and female, and the 4-6 monthly age, sexual maturity, unpregnancy does not produce, the about 25kg of body weight.
Two, Animal Anesthesia and preparation
Three, the full vagina resection of Chinese Small-sized pig causes the absence of vagina model.
Embodiment 7
By embodiment
6The laboratory animal be successfully established is after 1 week of rest, more capable vagina anaplasty.12 Chinese miniature pig groupings after the vagina anaplasty are grouped as follows:
Group 1: 4 Chinese miniature pigs after the vagina anaplasty (group 1-1 pig, group 1-2 pig, group 1-3 pig, group 1-4 pig).
Group 2: after the vagina anaplasty, the vaginal stent that embodiment 5 is obtained is positioned over (group 2-1 pig, group 2-2 pig, group 2-3 pig, pig group 2-4 pig) in cave, artificial vagina chamber.
Group 3: after the vagina anaplasty, the vaginal stent that embodiment 1 is obtained is positioned over (group 3-1 pig, group 3-2 pig, group 3-3 pig, group 3-4 pig) in cave, artificial vagina chamber.
Vagina ultrastructure by pig after the above-mentioned vagina anaplasty of electron microscopic observation, the results are shown in Table 1
Table 1: vagina anaplasty each pig vagina contracture situation (each pig vagina contracture area accounts for the percentage ratio of artificial vagina area) after two weeks
| ? | No. 1 pig | No. 2 pigs | No. 3 pigs | No. 4 pigs |
| Group 1 | 50% | 55% | 52% | 50% |
| Group 2 | 12% | 10% | 11% | 13% |
| Group 3 | 5% | 7% | 4% | 3% |
After vaginoplasty, do not place vaginal stent, the contracture rate of artificial vagina is very high; After vaginoplasty, place vaginal stent, can reduce the contracture rate of artificial vagina; Contain the contracture rate that estrogenic vaginal stent reduces artificial vagina greatly.
The present invention, by the polymethyl methacrylate resin material is combined with estrogen, prepares the vaginal stent with estrogen slow-release capability, thereby the treatment of the treatment of vaginal stent and these two aspects of estrin treatment is united effectively.Therefore, this vaginal stent with slow-release function has very large potentiality in clinical practice afterwards.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the inventive method; can also make some improvement and supplement, these improvement and supplement and also should be considered as protection scope of the present invention.
Claims (4)
1. the application of vaginal stent in the slow-release medicine of the artificial vagina of preparation treatment that contains polymethyl methacrylate resin, the described vaginal stent that contains polymethyl methacrylate resin, polymethyl methacrylate resin, estriol, consist of, described polymethyl methacrylate resin, estriol weight ratio are 20:(5-8).
2. application according to claim 1, described polymethyl methacrylate resin, estriol weight ratio are 4:1.
3. a vaginal stent that contains polymethyl methacrylate resin, be comprised of polymethyl methacrylate resin, estriol, it is characterized in that, described polymethyl methacrylate resin, estriol weight ratio are 20:(5-8).
4. vaginal stent according to claim 3, is characterized in that, described polymethyl methacrylate resin, estriol weight ratio are 4:1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013103333810A CN103405810A (en) | 2013-08-02 | 2013-08-02 | Vagina mold containing methyl methacrylate resin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013103333810A CN103405810A (en) | 2013-08-02 | 2013-08-02 | Vagina mold containing methyl methacrylate resin |
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| CN103405810A true CN103405810A (en) | 2013-11-27 |
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| CN2013103333810A Pending CN103405810A (en) | 2013-08-02 | 2013-08-02 | Vagina mold containing methyl methacrylate resin |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1548013A (en) * | 2003-05-14 | 2004-11-24 | 上海市计划生育科学研究所 | Simple vaginal ring making process |
| WO2004100874A2 (en) * | 2003-05-07 | 2004-11-25 | Merck & Co., Inc. | Androgen receptor modulators and methods of use thereof |
| CN101152102A (en) * | 2007-09-13 | 2008-04-02 | 李风 | Cunt shaping expanding device |
| CN201131825Y (en) * | 2007-09-13 | 2008-10-15 | 李风 | Vagina shaping dilator |
| CN101351188A (en) * | 2005-08-12 | 2009-01-21 | 药物技术公司 | Estrogen compositions and therapeutic methods of use thereof |
| CN102098991A (en) * | 2008-02-04 | 2011-06-15 | 特卫华妇女健康有限公司 | Monolithic intravaginal rings comprising progesterone and methods of making and uses thereof |
-
2013
- 2013-08-02 CN CN2013103333810A patent/CN103405810A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004100874A2 (en) * | 2003-05-07 | 2004-11-25 | Merck & Co., Inc. | Androgen receptor modulators and methods of use thereof |
| CN1548013A (en) * | 2003-05-14 | 2004-11-24 | 上海市计划生育科学研究所 | Simple vaginal ring making process |
| CN101351188A (en) * | 2005-08-12 | 2009-01-21 | 药物技术公司 | Estrogen compositions and therapeutic methods of use thereof |
| CN101152102A (en) * | 2007-09-13 | 2008-04-02 | 李风 | Cunt shaping expanding device |
| CN201131825Y (en) * | 2007-09-13 | 2008-10-15 | 李风 | Vagina shaping dilator |
| CN102098991A (en) * | 2008-02-04 | 2011-06-15 | 特卫华妇女健康有限公司 | Monolithic intravaginal rings comprising progesterone and methods of making and uses thereof |
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Application publication date: 20131127 |