CN103315711B - Medical endoscopic Cherenkov fluorescence imaging system - Google Patents
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- CN103315711B CN103315711B CN201310261548.7A CN201310261548A CN103315711B CN 103315711 B CN103315711 B CN 103315711B CN 201310261548 A CN201310261548 A CN 201310261548A CN 103315711 B CN103315711 B CN 103315711B
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Abstract
The invention discloses a medical endoscopic Cherenkov fluorescence imaging system which is characterized by comprising an endoscope probe, an optical fiber image transmission bundle, a detection device and a computing and imaging device; one end of the optical fiber image transmission bundle is connected with the endoscope probe, the other end of the optical fiber image transmission bundle is connected with the detection device; the computing and imaging device is connected with the detection device. The medical endoscopic Cherenkov fluorescence imaging system expands diagnosis range of an endoscope and improves diagnosis precision and early diagnosis capacity of the endoscope, can be used for any endoscopic systems with standard biopsy channels, is easy, flexible and convenient to operate and easy to control, and accordingly has widespread application prospect.
Description
Technical field
The present invention relates to medical imaging technology field, the one being specifically related to optical molecular imaging technical field is medical through endoscope Cherenkov fluoroscopic imaging systems, and this system can be applicable to clinical early structure and the molecular specificity imaging of the chamber class loading diseases such as gastroenteric tumor.
Background technology
As a kind of emerging optical molecular image technology, Cherenkov's fluorescence imaging is based on Cherenkov's phenomenon, by detecting visible ray that some radionuclide produces in nuclear decay process and near infrared light carries out imaging.Because existing a large amount of nucleic probes is ratified by Food and Drug Administration the Clinics and Practices being applied to various disease clinically, therefore provide new approaches by the molecular probe confinement problems faced for the clinical Transformation Application of optical molecular image technology.Endoscopy refers to be sent into body in by detecting instrument through human body natural's tract by external, then to the technology that deep layer disease in body detects through row, the optical signalling tissue penetration confinement problems faced for the clinical Transformation Application of optical molecular image technology provides effective solution.
Olympus Co., Ltd is at its utility model patent application documents " endoscope-use insertion unit and endoscopic system ", number of patent application 200620012071.4, provides in applying date 2006-4-5 and a kind ofly easily can insert endoscope in the body cavity of large intestine etc., discloses and do not cause suffering to patient, can improve endoscope insertion part to endoceliac insertion.But the structural change of internal organs lumenal tissue pathological changes can only detect in the endoscope of this kind of routine, can not the function of earlier detection pathological changes and the change of molecular level, be difficult to be applied to internal organs lumenal tissue disease, as the early diagnosis of gastroenteropathy.
In order to the change of the early function and molecular level that detect internal organs lumenal tissue disease, research worker proposes and is combined with molecular image technology by Endoscopy, as inner peeping type photoacoustic imaging system, see Yi Yuan, " Preclinical photoacoustic imaging endoscopebased on acousto-optic coaxial system using ring transducer, " Optics Letters, 35, 2266-2268 (2010) (Yuan Yi, based on the pre-clinical photoacoustic imaging endoscope of the optoacoustic coaxial system of employing loop sensor, optics letter, 35, 2266-2268(2010)), inner peeping type near-infrared optical 3-D imaging system, see DaqingPiao, " Endoscopic, rapid near-infrared opticaltomography, " Optics Letters, 31,2876-2878 (2006) (Piao great Qing, the quick near-infrared optical fault imaging of inner peeping type, optics letter, 31,2876-2878(2006)), .In addition, Korea Electrician Tech Research Inst and Mai Di Mil company are in its patent application document " fluorescence endoscope device and use this device method to imaging of tissue in health ", number of patent application 02146866.4, propose in applying date 2002-10-16 a kind of fluorescence endoscope device and use this device in health to the method for imaging of tissue, the degree of accuracy of disease examination can be improved.The change of pathological changes function and molecular level can detect in the endoscope of this kind of fusion molecule image technology, realizes the early diagnosis of internal organs lumenal tissue disease, but due to the limitation of molecular probe, is difficult to carry out clinical Transformation Application.
In order to advance the clinical Transformation Application of the endoscope of fusion molecule image technology, Cherenkov's Imaging-PAM combines with endoscope by research worker, propose a kind of inner peeping type Cherenkov fluoroscopic imaging systems, see Sri-RajasekharKothapalli, " Endoscopicimaging of Cerenkov luminescence, " Biomedical Optics Express, 3 (6), 1215-1225 (2012) (Sri-RajasekharKothapalli, inner peeping type Cherenkov fluorescence imaging, Photobiology bulletin, 3(6), 1215-1225(2012)), this system utilizes fibre opic endoscope and highly sensitive CCD camera, gathers Cherenkov's fluorescence signal of organism body surface.But this inner peeping type Cherenkov fluoroscopic imaging systems can not provide the White-light image of organism body surface, cannot locate the accurate location of pathological changes; In addition, clinically for different diagnosis positions, the endoscope's kind used is not identical yet, and therefore this inner peeping type Cherenkov fluoroscopic imaging systems does not have versatility.
Summary of the invention
The object of the invention is to solve the deficiency existed in above-mentioned technology, there is provided a kind of can use in flexible-pipe endoscope medical through endoscope Cherenkov fluoroscopic imaging systems, be combined by the white light structural images and inner targeting target that gather detected object surface the Cherenkov's fluoroscopic image sent with probe, obtain two-dimensional position and the distributed intelligence of the inner targeting target of detected object.
To achieve these goals, the technical solution used in the present invention is as follows:
A kind of medical through endoscope Cherenkov fluoroscopic imaging systems, described system comprises:
Endoscope probe, for gathering detected object surface white light signal and/or the inner targeting target of detected object is combined the Cherenkov's fluorescence signal sent with probe;
Optical fiber image transmission beam, one end is connected with described endoscope probe, for transmitting described white light signal and/or described Cherenkov's fluorescence signal;
Sniffer, is connected with the described optical fiber image transmission beam other end, for the described white light signal through optical fiber image transmission beam transmission and/or Cherenkov's fluorescence signal are converted into the signal of telecommunication;
Calculate and imaging device, be connected with described sniffer, for carrying out subsequent treatment to the signal of telecommunication after described conversion, the white light structural images and/or the inner targeting target of detected object that obtain detected object surface are combined the Cherenkov's fluoroscopic image sent with probe.
It should be noted that, described endoscope probe comprises speck mirror, GRIN Lens, and transparent sheath, wherein, described speck mirror collects detected object surface white light signal and/or Cherenkov's fluorescence signal, and forms the photon light beam of multi-beam collimation, and it is intrafascicular that described photon light beam focuses on described imaging fiber through described GRIN Lens; Described speck mirror and GRIN Lens are arranged in described transparent sheath.
It should be noted that, described sniffer comprises the coupled lens set gradually, imaging len, and planar array detector, wherein, detected object surface white light signal and/or Cherenkov's fluorescence signal are converted into multi-path parallel light by described coupled lens, focus to the sensitive area of described planar array detector through described imaging len, then by described planar array detector, optical signal are converted into electric signal transmission to described calculating and imaging device.
It should be noted that, described calculating and imaging device comprise image pick-up card, and connected computer, and wherein, described planar array detector is connected with image pick-up card.
As the preferred scheme of one, described planar array detector is CCD camera or CMOS camera.
It should be noted that, described endoscope distal end is provided with four through holes, is respectively illumination channel, and CCD imaging device and activity detect mouth, and wherein, described endoscope probe is arranged at described activity and detects mouth.
A medical method through the imaging of endoscope Cherenkov fluoroscopic imaging systems, said method comprising the steps of:
(1a) gather White-light image, the illumination channel arranged by medical alimentary tract endoscope front end provides background illumination, then utilizes the white light signal on endoscope probe acquisition target surface;
(1b) endoscope probe receives white light signal, and formed the photon light beam of multi-beam collimation by speck mirror, it is intrafascicular that described photon light beam focuses on described imaging fiber through described GRIN Lens;
(1c) described photon light beam transfers to described sniffer by described imaging fiber bundle;
(1d) described photon light beam is converted into multi-path parallel light by the coupled lens in described sniffer, the sensitive area of described planar array detector is focused to through described imaging len, by described planar array detector, optical signal is converted into electric signal transmission to described calculating and imaging device again, obtains the White-light image on acquisition target surface;
(2a) gather Cherenkov's fluoroscopic image, close the illumination channel of medical alimentary tract endoscope front end, then utilize Cherenkov's fluorescence signal that endoscope probe collection emits due to targeting probe nuclei element decay in object;
(2b) endoscope probe receives Cherenkov's fluorescence signal, and formed the photon light beam of multi-beam collimation by speck mirror, it is intrafascicular that described photon light beam focuses on described imaging fiber through described GRIN Lens;
(2c) described photon light beam transfers to described sniffer by described imaging fiber bundle;
(2d) described photon light beam is converted into multi-path parallel light by the coupled lens in described sniffer, the sensitive area of described planar array detector is focused to through described imaging len, by described planar array detector, optical signal is converted into electric signal transmission to described calculating and imaging device again, obtains Cherenkov's fluoroscopic image on acquisition target surface.
(3) image denoising and fusion, wherein, the White-light image on surface step (1a) and step (2a) collected and Cherenkov's fluoroscopic image, carry out image denoising and fusion treatment to its image on computers, obtain fusion image;
(4) obtain position and the distributed intelligence of pathological changes, wherein, based on the fusion image that step (3) obtains, two-dimensional position information and distributed intelligence that targeted probes in acquisition target corresponds to its surface can be obtained.
Beneficial effect of the present invention is:
1, double diagnosis.Both the pathological structure metamorphosis on detected object surface can have been observed directly by medical endoscope, the change of the inner pathological changes function of detected object and molecular level can be obtained again, and then obtain two-dimensional position information and the distributed intelligence of the inner targeted probes of detected object.Therefore extend the diagnostic area of endoscope, improve diagnostic accuracy and the early diagnosis ability of endoscope;
2, highly versatile.Because medical can to combine with conventional endoscope through endoscope Cherenkov fluoroscopic imaging systems of the present invention uses, do not need specific endoscope support.This system may be used for any Cherenkov's fluorescence imaging possessing the endoscopic system of standard biopsy passage and has very strong versatility;
3, simple to operate, flexible, convenient.Endoscope is when Diagnosis and Treat disease, and operator and assistant and other staff, can carry out various operation under the help of monitor, makes the operator of each side can tacit cooperation and safety.Thus operate flexibly, conveniently, be easy to grasp.
Accompanying drawing explanation
Fig. 1 is be the block schematic illustration of structure of the present invention;
Fig. 2 is further structural principle schematic diagram in Fig. 1;
Fig. 3 is that the present invention coordinates medical alimentary tract endoscope schematic diagram;
Fig. 4 is the flow chart of imaging system using method of the present invention.
Detailed description of the invention
In order to make object of the present invention, technical scheme and advantage clearly understand, below in conjunction with drawings and Examples, the present invention is further elaborated.Specific embodiment described herein only for explaining the present invention, is not intended to limit the present invention.
As shown in Figure 1 and Figure 2, the present invention is a kind of medical through endoscope Cherenkov fluoroscopic imaging systems, and described system comprises:
Endoscope probe 1, for gathering detected object surface white light signal and/or the inner targeting target of detected object is combined the Cherenkov's fluorescence signal sent with probe;
Optical fiber image transmission beam 2, one end is connected with described endoscope probe 1, for transmitting described white light signal and/or described Cherenkov's fluorescence signal;
Sniffer 3, is connected with described optical fiber image transmission beam 2 other end, for the described white light signal that transmits through optical fiber image transmission beam 2 and/or Cherenkov's fluorescence signal are converted into the signal of telecommunication;
Calculate and imaging device 4, be connected with described sniffer 3, for carrying out subsequent treatment to the signal of telecommunication after described conversion, the white light structural images and/or the inner targeting target of detected object that obtain detected object surface are combined the Cherenkov's fluoroscopic image sent with probe.
It should be noted that, described endoscope probe 1 comprises speck mirror 11, GRIN Lens 12, and transparent sheath 13, wherein, described speck mirror 11 collects detected object surface white light signal and/or Cherenkov's fluorescence signal, and forms the photon light beam of multi-beam collimation, and described photon light beam focuses in described imaging fiber bundle 2 through described GRIN Lens 12; Described speck mirror 11 is arranged in described transparent sheath 13 with GRIN Lens 12.
What needs further illustrated is, described sniffer 3 comprises the coupled lens 31 set gradually, imaging len 32, and planar array detector 33, wherein, detected object surface white light signal and/or Cherenkov's fluorescence signal are converted into multi-path parallel light by described coupled lens 31, focus to the sensitive area of described planar array detector 33 through described imaging len 32, then by described planar array detector 33, optical signal are converted into electric signal transmission to described calculating and imaging device 4.
Need to further illustrate, described calculating and imaging device 4 comprise image pick-up card 41, and connected computer 42, and wherein, described planar array detector 33 is connected with image pick-up card 41.
As the preferred scheme of one, described planar array detector 33 is CCD camera or CMOS camera.
Figure 3 shows that the present invention coordinates medical alimentary tract endoscope to use schematic diagram, this alimentary tract endoscope 6 is provided with four through holes, be respectively illumination channel 8, photographic head 9 and biopsy channel 7, wherein, be describedly medically arranged at described activity through endoscope Cherenkov fluoroscopic imaging systems endoscope probe 1 and detect mouth 7.It should be noted that, during detection, described endoscope probe 1 detects mouth 7 from described activity and stretches out, and arrives near detected object.
As shown in Figure 4, a kind of medical method through the imaging of endoscope Cherenkov fluoroscopic imaging systems, said method comprising the steps of:
(1a) gather White-light image, the illumination channel arranged by medical alimentary tract endoscope front end provides background illumination, then utilizes the white light signal on endoscope probe acquisition target surface;
(1b) endoscope probe receives white light signal, and formed the photon light beam of multi-beam collimation by speck mirror, it is intrafascicular that described photon light beam focuses on described imaging fiber through described GRIN Lens;
(1c) described photon light beam transfers to described sniffer by described imaging fiber bundle;
(1d) described photon light beam is converted into multi-path parallel light by the coupled lens in described sniffer, the sensitive area of described planar array detector is focused to through described imaging len, by described planar array detector, optical signal is converted into electric signal transmission to described calculating and imaging device again, obtains the White-light image on acquisition target surface;
(2a) gather Cherenkov's fluoroscopic image, close the illumination channel of medical alimentary tract endoscope front end, then utilize Cherenkov's fluorescence signal that endoscope probe collection emits due to targeting probe nuclei element decay in object;
(2b) endoscope probe receives Cherenkov's fluorescence signal, and formed the photon light beam of multi-beam collimation by speck mirror, it is intrafascicular that described photon light beam focuses on described imaging fiber through described GRIN Lens;
(2c) described photon light beam transfers to described sniffer by described imaging fiber bundle;
(2d) described photon light beam is converted into multi-path parallel light by the coupled lens in described sniffer, the sensitive area of described planar array detector is focused to through described imaging len, by described planar array detector, optical signal is converted into electric signal transmission to described calculating and imaging device again, obtains Cherenkov's fluoroscopic image on acquisition target surface.
(3) image denoising and fusion, wherein, the White-light image of subject surface step (1a) and step (2a) collected and Cherenkov's fluoroscopic image, carry out image denoising and fusion treatment to its image on computers, obtain fusion image;
(4) obtain position and the distributed intelligence of pathological changes, wherein, based on the fusion image that step (3) obtains, two-dimensional position information and distributed intelligence that targeted probes in acquisition target corresponds to its surface can be obtained.
As the preferred scheme of one, the time of exposure of the planar array detector in described step (1d) is set to 0.01 second.
As the preferred scheme of one, the time of exposure of the planar array detector in described step (2d) is set to 5 minutes.
It should be noted that, the targeted probes in acquisition target is Na
131i nucleic probe, Cherenkov's fluorescence is produced by the radionuclide decay in probe, it will be understood by those skilled in the art that targeted probes also can be
18f-FDG nucleic probe etc.
For a person skilled in the art, according to technical scheme described above and design, other various corresponding change and distortion can be made, and all these change and distortion all should belong within the protection domain of the claims in the present invention.
Claims (5)
1. medically it is characterized in that through an endoscope Cherenkov luminescence imaging system, described system comprises:
Endoscope probe, for gathering detected object surface white light signal and/or the inner targeting target of detected object is combined the Cherenkov's fluorescence signal sent with probe;
Optical fiber image transmission beam, one end is connected with described endoscope probe, for transmitting described white light signal and/or described Cherenkov's fluorescence signal;
Sniffer, is connected with the described optical fiber image transmission beam other end, for the described white light signal through optical fiber image transmission beam transmission and/or Cherenkov's fluorescence signal are converted into the signal of telecommunication;
Calculate and imaging device, be connected with described sniffer, for carrying out subsequent treatment to the signal of telecommunication after described conversion, the white light structural images and/or the inner targeting target of detected object that obtain detected object surface are combined the Cherenkov's fluoroscopic image sent with probe.
2. according to claim 1 medical through endoscope Cherenkov luminescence imaging system, it is characterized in that, described endoscope probe comprises speck mirror, GRIN Lens, and transparent sheath, wherein, described speck mirror collects detected object surface white light signal and/or Cherenkov's fluorescence signal, and forming the photon light beam of multi-beam collimation, it is intrafascicular that described photon light beam focuses on described fibre optic image transmission through described GRIN Lens; Described speck mirror and GRIN Lens are arranged in described transparent sheath.
3. according to claim 1 medical through endoscope Cherenkov luminescence imaging system, it is characterized in that, described sniffer comprises the coupled lens set gradually, imaging len, and planar array detector, wherein, detected object surface white light signal and/or Cherenkov's fluorescence signal are converted into multi-path parallel light by described coupled lens, focus to the sensitive area of described planar array detector through described imaging len, then by described planar array detector, optical signal is converted into electric signal transmission to described calculating and imaging device; Described planar array detector is connected with imaging device with calculating.
4. according to claim 3ly medically to it is characterized in that through endoscope Cherenkov luminescence imaging system, described calculating and imaging device comprise image pick-up card, and connected computer, and wherein, described planar array detector is connected with image pick-up card.
5. utilize a medical method of carrying out imaging through endoscope Cherenkov luminescence imaging system for claim 4, it is characterized in that, said method comprising the steps of:
S1 gathers White-light image;
The illumination channel that S1.1 is arranged by medical alimentary tract endoscope front end provides background illumination, then utilizes the white light signal on endoscope probe acquisition target surface;
S1.2 endoscope probe receives white light signal, and formed the photon light beam of multi-beam collimation by speck mirror, it is intrafascicular that described photon light beam focuses on described fibre optic image transmission through GRIN Lens;
Described in S1.3, photon light beam transfers to described sniffer by described optical fiber image transmission beam;
Described photon light beam is converted into multi-path parallel light by the coupled lens in sniffer described in S1.4, the sensitive area of described planar array detector is focused to through described imaging len, by described planar array detector, optical signal is converted into electric signal transmission to described calculating and imaging device again, obtains the White-light image on acquisition target surface;
S2 gathers Cherenkov's fluoroscopic image;
S2.1 closes the illumination channel of medical alimentary tract endoscope front end, then utilizes Cherenkov's fluorescence signal that endoscope probe collection emits due to targeting probe nuclei element decay in object;
S2.2 endoscope probe receives Cherenkov's fluorescence signal, and formed the photon light beam of multi-beam collimation by speck mirror, it is intrafascicular that described photon light beam focuses on described fibre optic image transmission through described GRIN Lens;
Described in S2.3, photon light beam transfers to described sniffer by described optical fiber image transmission beam;
Described photon light beam is converted into multi-path parallel light by the coupled lens in sniffer described in S2.4, the sensitive area of described planar array detector is focused to through described imaging len, by described planar array detector, optical signal is converted into electric signal transmission to described calculating and imaging device again, obtains Cherenkov's fluoroscopic image on acquisition target surface;
S3 image denoising and fusion, wherein, the White-light image of the subject surface collected by S1 and S2 and Cherenkov's fluoroscopic image, carry out image denoising and fusion treatment to its image on computers, obtain fusion image;
S4 obtains fusion image information, wherein, based on the fusion image that S3 obtains, can obtain two-dimensional position information and distributed intelligence that targeted probes in acquisition target corresponds to its surface.
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