CN102824154A - Combined endoscope imaging system based on OCT (Optical Coherence Tomography) and imaging method - Google Patents
Combined endoscope imaging system based on OCT (Optical Coherence Tomography) and imaging method Download PDFInfo
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Abstract
The invention discloses a combined endoscope imaging system based on an OCT (Optical Coherence Tomography) and an imaging method. The combined endoscope imaging system comprises an endoscope imaging device which is controlled by a computation control unit and is provided with an OCT imaging system and a photoelectric imaging or image guide optical fiber imaging system; the endoscope imaging device comprises a reference arm and an endoscope with a sample arm; the endoscope is internally provided with a plurality of channels; and each channel is internally provided with an OCT imaging probe, a photoelectric imaging probe or an image guide optical fiber bundle and a light guide fiber bundle. OCT imaging and photoelectric imaging or image guide optical fiber bundle imaging are combined to realize real video images on the surface and the periphery of a tissue of an observed position in real time and obtain a two-dimensional tomography image under a certain depth of the skin of the tissue at the position. A visible light source 2 also can be added to be coupled into the OCT imaging system so that an OCT imaging probe scanning light bundle is accurately positioned to a target region and the accurate positioning and scanning of a pathological change region of the tissue of a sample can be realized.
Description
Technical field
The present invention relates to a kind of endoscope apparatus, relate in particular to a kind of compound endoscopic imaging system and formation method based on OCT; Belong to the endoscopic imaging technical field.
Background technology
The core technology of conventional endoscope adopts mostly to lead as fibre bundle and is carried out to picture or adopts photoelectronic imaging to be carried out to picture; This type of endoscope only can observe from tissue surface; Yet often the symptom of early-stage cancer betides the following 1-3 mm depth of epidermis, and therefore above-mentioned endoscope seems powerless.The endoscope that carries out medical imaging through ultrasonic principle is also arranged in addition, and this type of endoscope can obtain organizational information darker below the biological tissue top layer, but resolution is merely a millimeter magnitude, can not effectively detect and diagnoses microscopic structure.
For addressing the above problem; Endoscope apparatus of the present invention combines photoelectronic imaging with the OCT imaging; For satisfying the OCT based endoscopic imaging; OCT in the endoscope of the present invention probe adopts based on micro electro mechanical system (MEMS) technology (microelectromechanical systems; Abbreviation MEMS) scanning micro-mirror carries out optical scanning, can make the OCT probe size enough little so that insert the particularly use in human body alimentary canal of various passages smoothly, and the OCT imaging technique is subject to the microminiaturization of OCT optic probe always in the intravital application of people.
Endoscope apparatus of the present invention has solved the faultage image problem that conventional endoscope can not obtain pathological tissues; The OCT image of apparatus of the present invention has micron order resolution; May detect the ability of minute lesion under the human body viscera top layer; Thereby realize the early lesion diagnosis, especially the mankind's first killer--on the early diagnosis of cancer, have bright prospects.The present invention has harmless noinvasive and characteristics of real time; Section need not to take a sample; Just can be accurately errorless find pathological tissues, can diagnosis and operation be carried out simultaneously, help the doctor to implement more accurate operation technique; Removal lesion tissue accurately can alleviate recovery time after patient's misery and the desmopyknosis in addition greatly.
Summary of the invention
The present invention seeks to provide a kind of the OCT optical image technology is applied to endoscope to the defective that prior art exists; And annex the function that conventional endoscope obtains video image simultaneously; Can be used for the auxiliary detection and the diagnosis of early lesion in the human body; Clinical practices such as biopsy sample circuit surgical navigational, and monitoring after operation accurately.The present invention is except that industrial endoscope is used; Be mainly used in the noinvasive to the inside of human body tissue, real-time, high resolution three-dimensional imaging; Its resolution can effectively be told majority and come from 2-3 millimeter under the organ epidermis up to 1～10 micron, early cancer's cell of several microns sizes in the epithelial tissue.The early lesion that can be applicable to each internal organs (lung, intestinal, liver, bladder etc.) detects.
The present invention adopts following technical scheme for realizing above-mentioned purpose:
A kind of compound endoscopic imaging system based on OCT comprises the endoscopic imaging device that has OCT imaging system and photoelectronic imaging or lead picture fibre bundle imaging system by calculation control unit control; Said endoscopic imaging device comprises reference arm and the endoscope that has sample arm; Be provided with a plurality of passages in the said endoscope, be provided with OCT imaging probe, photoelectronic imaging probe in the said passage or lead picture fibre bundle and fibre-optic bundle.
Further, said endoscope apparatus also comprises swept light source, visible light source, cold light source, detector, 2*1 fiber coupler and blender; Said swept light source is sent to calculation control unit with triggering signal; The outfan of said swept light source and said visible light source is connected the input of said 2*1 fiber coupler, and the outfan of said 2*1 fiber coupler is connected with blender, and the light path output port of said blender is connected respectively to reference arm and sample arm; The input of said detector connects the electric signal output port of blender, and its outfan connects calculation control unit; Said cold light source is connected with fibre-optic bundle in the said sample arm; Photoelectronic imaging device in the said sample arm or the optical signal of leading as fibre bundle transfer to calculation control unit with analog electrical signal after opto-electronic conversion.
Further, said reference arm is made up of the stationary mirror of condenser lens and coating.
Further, said calculation control unit comprises data collecting card, CPU center, display unit and drive controlling plate; The input of said data collecting card respectively with swept light source electric signal end, detector outfan and said sample arm in the photoelectronic imaging passage be connected, its outfan is connected to display unit through the CPU center; The input of said drive controlling plate connects the CPU center, and outfan connects data collecting card and OCT imaging probe respectively.
Be provided with 4 or 5 passages when further, said endoscope is for diagnostic endoscopes; It comprises when being 4 passages: an OCT imaging probe passage, and two optical fibers beam passages and photoelectronic imaging imaging probe passage or one lead picture fibre bundle passage; It comprises when being 5 passages: an OCT imaging probe passage, two optical fibers beam passages and two photoelectronic imaging probe passages or two lead picture fibre bundle passage.
Further, said endoscope is provided with 5 passages for diagnosis with when performing the operation compound endoscope; Comprise: OCT imaging probe passage, two optical fibers beam passages, photoelectronic imaging probe passage or one lead picture fibre bundle passage and an operating theater instruments passage.
Further, said endoscope also comprises handle interface module, connection tube and the endoscope distal end that sets gradually; Said connection tube is flexible steel in flat section tubing or soft or hard property connection tube or rigid connection tube.
Further, be provided with the constant aperture passage in the said endoscope, said OCT imaging probe directly inserts in this constant aperture passage, through stretching OCT imaging probe connection tube adjustment probe positions.
Further, said OCT imaging probe comprises MEMS micro mirror, lens subassembly, window, electrical connections and shell; Said lens subassembly focuses on input beam and after the reflection of MEMS micro mirror, sees through window and penetrate at sample surfaces.
Further, also comprise stationary mirror in the said OCT imaging probe, said lens subassembly input beam is focused on and after the fixation reflex mirroring directive MEMS micro mirror, penetrate at sample surfaces through window through MEMS micro mirror reflection back again.
Further, said OCT imaging probe and endoscope path way adopt the connected mode of bonding or welding to form an integral body, adjust probe window and sample present position through adjusting said endoscope position.
Further, said OCT imaging probe has side direction, forward direction and three kinds of scanning imagery working methods of side forward direction; When it was side direction, probe window was arranged at OCT imaging probe sidewall; When it was forward direction or side forward direction, probe window was arranged at OCT imaging probe front end.
A kind of compound endoscopic imaging method based on OCT as claimed in claim 1, said method comprises the steps:
1) cold light source obtains R, G, the trichroism rotation light of B respectively through behind the optical filter; Illuminate sample surfaces through fibre-optic bundle, the real image of photoelectronic imaging device sense object is after opto-electronic conversion is also amplified, and the signal of telecommunication after the amplification is after data collecting card is gathered; The signal of telecommunication is delivered to the CPU center carry out Flame Image Process and recovery; Convert analogue signal again to, obtain the sample surfaces image through R, G, B delivery outlet or video output, and show by display unit;
2) swept light source and visible light source two-way incident illumination are sent to blender after being coupled through the 2*1 fiber coupler, after the blender coupling is handled, obtain hybrid light source;
3) hybrid light source that obtains is incident upon sample surfaces after being sent to reference arm and sample arm respectively, and the light of returning through the sample surfaces diffuse scattering forms interference signal through blender;
4) interference signal is input to calculation control unit after the detector difference processing;
5) interference signal of calculation control unit after to difference processing carries out Fourier transformation, obtains the image of sample along depth direction;
6) the MEMS micro mirror in the calculation control unit control OCT imaging probe carries out one dimension or two-dimensional scan to the target area in the photoelectronic imaging zone; And at each scanning element repeating step 2)-5); Obtain the two and three dimensions tomographic map of target area tissue, and show through display unit.
Beneficial effect of the present invention: (1) combines the OCT imaging with photoelectronic imaging; The two dimension of sample tissue, three-dimensional real video image both can have been obtained in real time; Can also obtain two dimension, the three-dimensional optical faultage image of target area in real time; And the high-resolution with several micron levels can provide enough abundant sample tissue information to the doctor as medical endoscope, for the doctor provides foundation to the accurate diagnosis of pathology;
(2) can get into human oral cavity, otorhinolaryngology, bronchus, upper digestive tract and abdominal cavity by endoscope of the present invention; Various suspected lesion tissues are accurately scanned to obtain its optical section diagnose again; Cut into slices and save biological tissue's sample circuit; Alleviate less patient suffering greatly and shorten detection time, in view of endoscope of the present invention has adopted the MEMS optic probe, it is enough little to make that endoscope inserts the connection tube diameter;
(3) adopt multichannel endoscope by the present invention, number of channels generally can be less than 5, can not only can be used as diagnostic tool respectively as diagnostic endoscopes and operation endoscope, can also carry out the hands art by endoscope channel;
(4) rigid straight tube structure, soft or hard property connection tube structure are arranged and flexibly connect tubular construction by endoscope of the present invention connection tube, can be in various organs, digestive tract and chamber;
(5) by endoscope apparatus of the present invention, utilize visible light source 2 to be coupled into the OCT imaging system, can make OCT imaging probe scanning light beam accurately be positioned to the target area, can realize accurate location and scanning to the sample tissue lesion region;
(6) have pipeline plug-in type and integral structure to cooperate by endoscope of the present invention with the combination of OCT imaging probe, the OCT imaging probe is flexible and convenient to use, is convenient to white dismounting and assembling, and is convenient to safeguard;
(7) the OCT imaging probe has forward direction/side forward direction and side direction scanning imagery mode, increases the motility to sample scanning, can adopt the scan mode that is fit to carry out scanning imagery to different target areas.
(8) it is less that the OCT imaging probe adopts the integrated miniature probe size of MEMS micro mirror, and probe diameter adopts this integrated endoscope of probe can have reduced size generally at 2mm-5mm, can get into various chambers and catwalk smoothly.
Description of drawings
Fig. 1 endoscope apparatus block diagram of the present invention;
Fig. 2 endoscope distal end face of the present invention;
Fig. 3 endoscope of the present invention connection tube structure;
Fig. 4 OCT side direction of the present invention scanning imagery probe occupation mode 1;
Fig. 5 OCT forward direction of the present invention/side scan forward imaging probe occupation mode 1;
Fig. 6 OCT forward direction of the present invention/side scan forward imaging probe occupation mode 2;
Fig. 7 OCT side direction of the present invention scanning imagery probe occupation mode 2.
The specific embodiment
Shown in Figure 1, be a kind of compound endoscopic imaging system based on OCT and photoelectronic imaging, comprise the endoscopic imaging device that has OCT imaging system and photoelectronic imaging or lead picture fibre bundle imaging system by calculation control unit control; Said endoscopic imaging device comprises reference arm and the endoscope 109 that has sample arm; The front end of said endoscope 109 is provided with a plurality of endoscope probe passages, is provided with OCT imaging probe, photoelectronic imaging probe in the said endoscope probe passage or leads picture fibre bundle and fibre-optic bundle 106.
This endoscopic imaging system also comprises swept light source (being light source 1), visible light source (being light source 2), cold light source, detector, 2*1 fiber coupler 102, blender and reference arm 103, and said swept light source is sent to calculation control unit with triggering signal 101.The outfan of said swept light source and visible light source is connected the input of 2*1 fiber coupler, and the outfan of said 2*1 fiber coupler is connected with blender, and the light path output port of said blender is connected respectively to reference arm 103 and sample arm; Wherein, reference arm 103 is made up of the stationary mirror 105 of condenser lens 104 and coating.The input of said detector connects the electric signal output port of blender, and its outfan connects calculation control unit.Said cold light source is connected with fibre-optic bundle in the said sample arm.Photoelectronic imaging device 108 in the said sample arm or the optical signal of leading as fibre bundle transfer to calculation control unit with analog electrical signal after opto-electronic conversion.Said endoscope 109 also comprises handle interface module 116, connection tube 117 and the endoscope distal end 118 that sets gradually.Said calculation control unit comprises data collecting card, CPU center, display unit and drive controlling plate.The input of said data collecting card respectively with electric signal end, detector outfan and the said sample arm of swept light source in the photoelectronic imaging passage be connected, its outfan is connected to display unit through the CPU center.The input of said drive controlling plate connects the CPU center, and outfan connects the OCT imaging probe in data collecting card and the said endoscope 109 respectively.Wherein, said OCT imaging probe comprises MEMS micro mirror, lens subassembly, window, electrical connections and shell; Said lens subassembly focuses on input beam and after the reflection of MEMS micro mirror, sees through window and penetrate at sample surfaces; The scanning of MEMS micro mirror realizes horizontal one dimension or the two-dimensional scan of probe to sample.Can also be provided with stationary mirror in the said OCT imaging probe; Said lens subassembly focuses on input beam and directive MEMS micro mirror after the fixation reflex mirroring; After the micro mirror reflection, see through window again and penetrate at sample surfaces, this moment, the scanning of MEMS micro mirror also realized horizontal one dimension or the two-dimensional scan of probe to sample.
When it is 5 passages, comprise: OCT imaging probe passage 112, two optical fibers beam passages 202 and two photoelectronic imaging probe passages 115 or two lead picture fibre bundle passage 203.Can obtain the sample tissue three-dimensional image through two photoelectronic imaging binocular imagings; Carry out the scanning of OCT optical imagery through the OCT imaging probe to there being doubt region again; Endoscope apparatus will provide abundanter pathological diagnosis information to supply diagnosis during the boundary, realize diagnostic function.(in Fig. 2).
Said endoscope is provided with 5 passages for diagnosis with when performing the operation compound endoscope; Comprise: 202, one photoelectronic imagings of 112, two optical fibers beam passages of OCT imaging probe passage probe passages 115 or one lead picture fibre bundle passage 203 and an operating theater instruments passage 204.At first pathology is diagnosed, again operating theater instruments is inserted the passage operation that undergos surgery, realize diagnosis and the complex function of performing the operation through photoelectronic imaging and OCT imaging.(right) like Fig. 2.
Endoscope of the present invention connection tube has 3 kinds of structures; Flexible steel in flat section tubing, soft or hard property connection tube or rigid connection tube; The soft endoscope front end is rigid first end 303; Link to each other with operating portion through flexible steel in flat section tubing 304, can be used for the operation of the upper and lower digestive tract of human body and some organs or detect diagnosis, as shown in Figure 3 in.Soft or hard property endoscope distal end is rigid first end 303; The centre carries out the transition to rigid connection tube 301 through flexible steel in flat section tubing 302, and flexible steel in flat section tubing 304 has the crooked ability of left and right sides all directions forwards, backwards, relatively flexibly; Can be used for abdominal operation or detect diagnosis, a left side as shown in Figure 3.Rigid endoscope distal end is rigid first end 303, and is coupled by rigid direct-connected adapter 305.Can be used for the operation of otorhinolaryngology, bronchus, orthopaedics or brain section or detect diagnosis, the right side as shown in Figure 3.
Extremely shown in Figure 7 like Fig. 4.The OCT of endoscope imaging probe of the present invention has two kinds of occupation modes; Wherein a kind of is that endoscope forms the constant aperture passage; The OCT imaging probe directly inserts in the passage and uses, and reaches the adjustment probe positions through stretching and shrinking the probe connection tube, uses flexibly; Can carry out scanning imagery to the sample tissue of various complex environments; Here the OCT imaging probe has side direction, forward direction and three kinds of scanning imagery working methods of side forward direction, and the square probe window 408 among Fig. 4 is arranged at the probe sidewall, and the circular window 508 among Fig. 5 is arranged on the probe front end.
Also include OCT imaging probe 401,501 among Fig. 4, Fig. 5; Probe sweep 402,502, probe connection tube 403,503, photoelectronic imaging passage 404,504; Elder generation of endoscope end 405,505; Optical fibers beam passage 406,506, probe bending direction 407,507, probe window 408,508.
Like Fig. 6 and shown in Figure 7; Be the another kind of occupation mode of the OCT of endoscope imaging probe of the present invention; OCT imaging probe and endoscope path way adopt the connected mode of bonding or welding to form an integral body; The adjustment endoscope position is adjusted probe window and sample present position, and the OCT imaging probe carries out scanning imagery through side direction window or forward direction or side forward direction window.
Wherein, also include endoscope 601,701 among Fig. 6, Fig. 7, OCT forward direction imaging probe 602, OCT forward direction/side forward direction imaging probe 702; Lens subassembly 603,703, stationary mirror 604, probe window 605,704; Scanning probe scope 606,705, endoscope distal end face 607,708, MEMS micro mirror 608,707; MEMS electrical lead 609, endoscope path way 610,709, MEMS micro mirror pedestal 706.
OCT forward direction imaging probe window is arranged on the endoscope distal end face; Connect tube wall and endoscope path way and form an integral body, the light source that lens subassembly will be introduced endoscope focuses on the directive stationary mirror, after reflection directive MEMS micro mirror; The MEMS micro mirror adopts the micro mirror of electrothermal method work; Can realize two-dimensional scan, focused beam sees through window sample is scanned, and can obtain the sample three-dimensional tomographic image in conjunction with the OCT imaging system.
Fig. 1 can know; Its operation principle is: the light source 1 in the endoscopic system of the present invention is the swept light source that has than short-phase dry length; It is sent to data collecting card with triggering signal (Time trigger) 101; Light source 2 is that photoelectronic imaging can induced visible light source, and light source 1 and light source 2 two-way light are sent to blender after through the coupling of 2*1 fiber coupler, respectively this hybrid light source are sent to the OCT of the endoscope imaging probe end in reference arm and the sample arm respectively through the blender light-splitting processing; The light of returning through the sample diffuse scattering when reference arm and sample arm; The two-way light optical path difference that forms will produce when being in the coherence length scope interferes and the entering detector, through the detector difference processing, can obtain the organizational information of sample different depth; MEMS micro mirror 107 in the OCT imaging probe is done the two and three dimensions tomographic map that one dimension or two-dimensional scan just can obtain sample respectively; The drive controlling plate is that MEMS micro mirror 107 provides electricity to drive, and the CPU center sticks into row control to two panels and the data of reading in are handled, and display unit shows the two and three dimensions image of sample.
Light source 3 is a cold light source; Can obtain R, G, the trichroism rotation light of B respectively through optical filter, illuminate sample surfaces through fibre-optic bundle 106, the real image of photoelectronic imaging device 108 sense objects is through opto-electronic conversion; Convert optical signal the signal of telecommunication to and amplify; Through the data collecting card collection signal of telecommunication is delivered to the CPU center again and carry out Flame Image Process and recovery, convert analogue signal to, through R, G, B delivery outlet or video output; Show through display unit, can obtain clear amplification, real sample surfaces image.Obtain the photoelectronic imaging zone 111 of sample through the photoelectronic imaging image, can adopt the OCT probe to carry out optical scanning, can obtain the OCT imaging region 110 of sample interesting areas wherein.
Above-mentioned compound endoscopic imaging method concrete steps based on OCT are following:
1) cold light source obtains R, G, the trichroism rotation light of B respectively through behind the optical filter; Illuminate sample surfaces through fibre-optic bundle, the real image of photoelectronic imaging device sense object is after opto-electronic conversion is also amplified, and the signal of telecommunication after the amplification is after data collecting card is gathered; The signal of telecommunication is delivered to the CPU center carry out Flame Image Process and recovery; Convert analogue signal again to, obtain the sample surfaces image through R, G, B delivery outlet or video output, and show by display unit;
2) swept light source and visible light source two-way incident illumination are sent to blender after being coupled through the 2*1 fiber coupler, after blender is handled, obtain hybrid light source;
3) hybrid light source that obtains is incident upon sample surfaces after being sent to reference arm and sample arm respectively, and the frequency sweep light that frequency sweep light of returning through the sample surfaces diffuse scattering and reference arm reflect forms interference signal through blender;
4) interference signal is input to calculation control unit after the detector difference processing;
5) interference signal of calculation control unit after to difference processing carries out Fourier transformation, obtains the image of sample along depth direction;
6) the MEMS micro mirror in the calculation control unit control OCT imaging probe carries out one dimension or two-dimensional scan to the target area in the photoelectronic imaging zone; And at each scanning element repeating step 2)-5); Obtain sample two and three dimensions tomographic map, and show through display unit.
The above is merely preferred embodiment of the present invention, and is in order to restriction the present invention, not all within spirit of the present invention and principle, any modification of being done, is equal to replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (13)
1. the compound endoscopic imaging system based on OCT is characterized in that, comprises the endoscopic imaging device that has OCT imaging system and photoelectronic imaging or lead picture fibre bundle imaging system by calculation control unit control; Said endoscopic imaging device comprises reference arm and the endoscope that has sample arm; Be provided with a plurality of passages in the said endoscope, be provided with OCT imaging probe, photoelectronic imaging probe in the said passage or lead picture fibre bundle and fibre-optic bundle.
2. the compound endoscopic imaging system based on OCT as claimed in claim 1 is characterized in that said endoscope apparatus also comprises swept light source, visible light source, cold light source, detector, 2*1 fiber coupler and blender; Said swept light source is sent to calculation control unit with triggering signal; The outfan of said swept light source and said visible light source is connected the input of said 2*1 fiber coupler, and the outfan of said 2*1 fiber coupler is connected with blender, and the light path output port of said blender is connected respectively to reference arm and sample arm; The input of said detector connects the electric signal output port of blender, and its outfan connects calculation control unit; Said cold light source is connected with fibre-optic bundle in the said sample arm; Photoelectronic imaging device in the said sample arm or the optical signal of leading as fibre bundle transfer to calculation control unit with analog electrical signal after opto-electronic conversion.
3. according to claim 1 or claim 2 the compound endoscopic imaging system based on OCT is characterized in that said reference arm is made up of the stationary mirror of condenser lens and coating.
4. according to claim 1 or claim 2 the compound endoscopic imaging system based on OCT is characterized in that said calculation control unit comprises data collecting card, CPU center, display unit and drive controlling plate; The input of said data collecting card respectively with swept light source electric signal end, detector outfan and said sample arm in the photoelectronic imaging passage be connected, its outfan is connected to display unit through the CPU center; The input of said drive controlling plate connects the CPU center, and outfan connects data collecting card and OCT imaging probe respectively.
5. the compound endoscopic imaging system based on OCT as claimed in claim 1 is characterized in that, said endoscope is provided with 4 or 5 passages during for diagnostic endoscopes; It comprises when being 4 passages: an OCT imaging probe passage, and two optical fibers beam passages and photoelectronic imaging imaging probe passage or one lead picture fibre bundle passage; It comprises when being 5 passages: an OCT imaging probe passage, two optical fibers beam passages and two photoelectronic imaging probe passages or two lead picture fibre bundle passage.
6. the compound endoscopic imaging system based on OCT as claimed in claim 1 is characterized in that, said endoscope is provided with 5 passages for diagnosis with when performing the operation compound endoscope; Comprise: an OCT imaging probe passage, two optical fibers beam passages, photoelectronic imaging imaging probe passage or one lead picture fibre bundle passage and an operating theater instruments passage.
7. like claim 1 or 5 or 6 described compound endoscopic imaging systems, it is characterized in that said endoscope also comprises handle interface module, connection tube and the endoscope distal end that sets gradually based on OCT; Said connection tube is flexible steel in flat section tubing or soft or hard property connection tube or rigid connection tube.
8. the compound endoscopic imaging system based on OCT as claimed in claim 7; It is characterized in that; Be provided with the constant aperture passage in the said endoscope, said OCT imaging probe directly inserts in this constant aperture passage, through stretching OCT imaging probe connection tube adjustment probe positions.
9. the compound endoscopic imaging system based on OCT as claimed in claim 1 is characterized in that said OCT imaging probe comprises MEMS micro mirror, lens subassembly, window, electrical connections and shell; Said lens subassembly focuses on input beam and after the reflection of MEMS micro mirror, sees through window and penetrate at sample surfaces.
10. the compound endoscopic imaging system based on OCT as claimed in claim 9; It is characterized in that; Also comprise stationary mirror in the said OCT imaging probe; Said lens subassembly input beam is focused on and after the fixation reflex mirroring directive MEMS micro mirror, penetrate at sample surfaces through window through micro mirror reflection back again.
11. like claim 1 or 9 or 10 described compound endoscopic imaging systems based on OCT; It is characterized in that; Said OCT imaging probe and endoscope path way adopt the connected mode of bonding or welding to form an integral body, adjust probe window and sample present position through adjusting said endoscope position.
12. the compound endoscopic imaging system based on OCT as claimed in claim 1 is characterized in that, said OCT imaging probe has side direction, forward direction and three kinds of scanning imagery working methods of side forward direction; When it was side direction, probe window was arranged at OCT imaging probe sidewall; When it was forward direction or side forward direction, probe window was arranged at OCT imaging probe front end.
13. the compound endoscopic imaging method based on OCT as claimed in claim 1 is characterized in that said method comprises the steps:
1) cold light source obtains R, G, the trichroism rotation light of B respectively through behind the optical filter; Illuminate sample surfaces through fibre-optic bundle, the real image of photoelectronic imaging device sense object is after opto-electronic conversion is also amplified, and the signal of telecommunication after the amplification is after data collecting card is gathered; The signal of telecommunication is delivered to the CPU center carry out Flame Image Process and recovery; Convert analogue signal again to, obtain the sample surfaces image through R, G, B delivery outlet or video output, and show by display unit;
2) swept light source and visible light source two-way incident illumination are sent to blender after being coupled through the 2*1 fiber coupler, after the blender coupling is handled, obtain hybrid light source;
3) hybrid light source that obtains is incident upon sample surfaces after being sent to reference arm and sample arm respectively, and the frequency sweep light that frequency sweep light of returning through the sample surfaces diffuse scattering and reference arm reflect forms interference signal through blender;
4) interference signal is input to calculation control unit after the detector difference processing;
5) interference signal of calculation control unit after to difference processing carries out Fourier transformation, obtains the image of sample along depth direction;
6) the MEMS micro mirror in the calculation control unit control OCT imaging probe carries out one dimension or two-dimensional scan to the target area in the photoelectronic imaging zone; And at each scanning element repeating step 2)-5); Obtain the two and three dimensions tomographic map of target area tissue, and show through display unit.
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