CN103202690A - Flexible epicardium electrocardio-electrode chip and preparation method thereof - Google Patents
Flexible epicardium electrocardio-electrode chip and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
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- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
- A61B5/28—Bioelectric electrodes therefor specially adapted for particular uses for electrocardiography [ECG]
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- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0209—Special features of electrodes classified in A61B5/24, A61B5/25, A61B5/283, A61B5/291, A61B5/296, A61B5/053
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/16—Details of sensor housings or probes; Details of structural supports for sensors
- A61B2562/166—Details of sensor housings or probes; Details of structural supports for sensors the sensor is mounted on a specially adapted printed circuit board
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Abstract
The invention relates to a flexible epicardium electrocardio-electrode chip. The chip comprises a flexible substrate, electrode units, electrode leads, lead connection points and insulating layers, wherein electrode units, electrode leads and lead connection points are arranged on the flexible substrate and are connected with one another electrically, insulating layers are arranged on the flexible substrate and cover electrode leads, and insulating layers are not arranged on surfaces of electrode units and lead connection points. The invention also relates to a preparation method of the flexible epicardium electrocardio-electrode chip. According to the electrode chip, a plurality of electrode units are arranged to form an electrode array, so that the minimum micron-scale spatial resolution can be achieved, the electrode chip is good in flexibility and deformation capability, can be attached to the surface of a heart and can be adapted to changes of the outline of the surface of the heart, the electrode is well attached to a target area on the surface of the heart, and damages such as extrusion and scratching, which are caused by the electrode during movement of the heart, can be effectively avoided. The chip can be used for qualitative diagnoses of heart diseases and accurate positioning of nidi and can provide objective evidences for targeted treatment.
Description
Technical field
The present invention relates to field of medical, particularly relate to a kind of flexible visceral pericardium electrocardioelectrode chip, also relate to a kind of flexible visceral pericardium electrocardioelectrode chip production method.
Background technology
9 from hands, foot, front etc. positions of conventional electrocardiographic examination arrangement electrode obtains macroscopical body surface ecg analyzed and judges heart disease.But owing to systemic asymmetric, non-rule, heterogeneity, the signal of telecommunication that heart produces exists decay, distortion and filter effect in external conductive process.The electrocardiosignal of body surface has evident difference with the Potential distribution of heart surface on amplitude and phase place in addition, and many electric physiological evenies might not arrive at surface observation.When occurring a plurality of exciting point simultaneously as cardiac muscle, the stack of several mappings will make body surface potential be difficult to determine.Body surface ecg can only qualitative observation, can not carry out the accurate location of focus, thereby cause diagnosis precision rate limited.Heart disease for complexity such as arrhythmia, myocardial ischemia then needs heart is directly checked the ability positioning and qualitative, thereby carries out the specific aim treatment.
The visceral pericardium electrocardio is as the method for a kind of accurate measurement and observation analysis cardiac electrical activity, and is different with the routine electrocardiogram inspection, and it can not only draw diagnosis on a macro scale, can also determine the exact position of pathological changes, for the specific aim treatment provides objective basis.It is to utilize multi-electrode system to cover epicardial surface the multiple spot synchronous recording is carried out in the cardiac electric excitement.Because electrod-array directly contacts with epicardial, and to the synchronized sampling of electrocardiosignal, therefore energy is objective and react the origin of electrocardio excitement and the process of propagation accurately.
In the U.S., 5,000,000 heart failure patients are nearly arranged, and annual newly-increased patient diagnosed's number is up to 550,000.With present case, with the disease of heart failure as main cause, its M ﹠ M is mainly from the cell-mediated myocardial infarction deficiency of alternative dry in developed countries such as the U.S..
Than the surface electrocardiogram record, visceral pericardium multiple tracks electrocardiogram system can provide the ventricular bipolar information of asymmetry, and very useful to monitoring Electrocardiographic variation in cardiac regeneration.At present external visceral pericardium electrocardio research is all made every effort to obtain the data that more accurate cardiac muscle is in proper order exciting and distribute with more electrode points.Because electrode number is numerous, data volume is big, thereby all is to adopt the method for off-line analysis to carry out electrophysiologic study mostly, is difficult to be applied to clinical.
In biomedical information extracted, electrode played the effect of transducer, and the bio electricity variation that it can produce living organism guides, and the change ion current is electronic current.What be used for electrocardiogram acquisition the earliest is needle electrode, but needle electrode only limits to local record, and along with research is goed deep into, the visceral pericardium electrocardio mainly adopted the pellet electrode of handled easily afterwards.
The main base material that is used for the epicardial lead sheet at present mostly is silicone rubber and thermoplastic, is convenient to realize that multidigit point detects.The base material of electrode should have good pliability and compliance, can adapt to contraction and the diastole of heart, and the size of electrode and relative spacing must satisfy Testing requirement, also will prevent from simultaneously visceral pericardium is caused damage.Can satisfy above-mentioned requirement though silicone rubber and thermoplastic are substrate, along with increasing of electrode, contact conductor easily chaotic, fracture, increase the difficulty of making and using, also can influence electrode points and epicardial attaching simultaneously.The hospital gauze that soaks into normal saline of somebody is as the base material of electrode in addition, evenly be sewn to electrode on the gauze before the art, the diameter of electrode reaches 1mm, spacing is 3mm, the material of electrode points commonly used generally adopts silver (diameter 0.2mm filamentary silver) or rustless steel (stainless steel silk of diameter 1.5mm), and the die opening of existing epicardial lead is generally 1-5.6mm.But in use also can there be same problem.
Also having research recently is that even distribution of electrode points is produced on the flexible printed circuit board with electrode design, and the electrode points surface exposes Copper Foil and does chemical gilding and handle.The lead-out wire of each electrode and flexible board form an integral body, and the raw material of electrode slice adopts polyimides, strengthen the row that reclines by reducing thickness to micro-meter scale.And electrode points adopts that copper outside is gold-plated to be reached long-time placement and be difficult for oxidation, guarantees excellent contact simultaneously.Yet, being subjected to the restriction of the performance of material own, Kapton can not stretch and fold, and local tolerance degree of strain is less than 1%.Even can improve the pliability of microelectrode array by the thickness of continuous reduction Kapton, but do the difficulty of processing that has increased electrode like this, because the restriction that is subjected to technology has to increase the processing dimension of electrode, thereby cause the resolution of electrode to descend, polyimides substrate thickness attenuate also makes the mechanical strength of microelectrode array and operability descend thereupon in addition.
Summary of the invention
Based on this, being necessary provides a kind of flexible visceral pericardium electrocardioelectrode chip at the problem of traditional epicardial lead sheet existence.
A kind of flexible visceral pericardium electrocardioelectrode chip, comprise: flexible substrates, electrode unit, contact conductor, lead-in wire junction point and insulating barrier, described electrode unit, contact conductor and lead-in wire junction point are formed electrode assemblie jointly, described electrode assemblie is located on the described flexible substrates, described electrode unit is connected to the lead-in wire junction point via contact conductor, realize being electrically connected, described insulating barrier is located on the described flexible substrates and is covered described contact conductor, described electrode unit is used for being electrically connected heart surface, and the material of described flexible substrates and insulating barrier is polydimethylsiloxane.
Among embodiment, described electrode assemblie comprises electrode layer therein, and the material of described electrode layer is a kind of in gold, titanium, the copper
Among embodiment, described electrode assemblie also comprises prime coat therein, and described electrode layer is located on the described prime coat, and the material of described prime coat is titanium, chromium, or comprises one or both the alloy in these two kinds of elements.
Therein among embodiment, described electrode unit also comprises decorative layer, described decorative layer is located at the electrode unit surface of described flexible substrates dorsad, the material of described decorative layer is platinum, iridium, or comprise one or both alloy or chemical compound in these two kinds of elements, perhaps a kind of in polypyrrole, poly-(3,4-ethene dioxythiophene), the polyaniline.
Among embodiment, described flexible substrates is positioned at the thickness of electrode unit part much smaller than other regional thickness of flexible substrates therein.
Therein among embodiment, the cross section of described flexible substrates is rectangle, described electrode unit and lead-in wire junction point are corresponding one by one, described electrode assemblie comprises about axisymmetric two row of described rectangular perpendicular bisector, described electrode unit and corresponding lead-in wire junction point are positioned at the same side of perpendicular bisector, described electrode unit is located at the position near described perpendicular bisector, corresponding lead-in wire junction point is positioned at the position near rectangle one side parallel with described perpendicular bisector, forms inside depression in the one side of described insulating barrier dorsad in the middle part of the described flexible visceral pericardium electrocardioelectrode chip.
Also be necessary to provide a kind of flexible visceral pericardium electrocardioelectrode chip production method.
A kind of preparation method of flexible nerve tract electrode comprises the following steps: step 1, in stiff base polydimethylsiloxane is set and forms flexible substrates; Step 2 forms electrode assemblie in described flexible substrates, and described electrode assemblie comprises the lead-in wire junction point, is used for being electrically connected the electrode unit of heart surface, reaches the contact conductor that is electrically connected described lead-in wire junction point and electrode unit; Step 3 arranges the polydimethylsiloxane that covers described electrode assemblie in described flexible substrates and forms insulating barrier, and forms opening in electrode unit and the lead-in wire junction point position of described insulating barrier, exposes described electrode unit and lead-in wire junction point; Step 4 is separated described flexible substrates from stiff base, obtain described flexible visceral pericardium electrocardioelectrode chip.
Among embodiment, described step 2 comprises: prepare a mask that is formed with the pierced pattern of described electrode assemblie shape therein; Described mask is adhere well on the described flexible substrates; Be pasted with deposit prime coat on the flexible substrates of described mask; Deposit one deck electrode layer on described prime coat; Described mask is removed on flexible substrates.
Therein among embodiment, also be included in the step of described electrode unit surface plating one deck decorative layer after the described step 3, the material of described decorative layer is platinum, iridium, or comprise one or both alloy or chemical compound in these two kinds of elements, perhaps a kind of in polypyrrole, poly-(3,4-ethene dioxythiophene), the polyaniline.
Among embodiment, described stiff base is the glass boss therein.
Above-mentioned flexible visceral pericardium electrocardioelectrode chip has good pliability and deformability, and the record position is accurate, contact is tight, good reproducibility.In addition in the micro-meter scale machining accuracy and spatial resolution that guarantee electrod-array, can realize 90% one dimension deformation and 20% two-dimentional deformation, do not need to reduce significantly substrate thickness and just can realize good conformal effect, realize the identical attaching of microelectrode array and heart surface, improve sensitivity.Simultaneously, the flexible matching performance good with heart can effectively reduce chip causes damage to visceral pericardium risk.In addition, chip still can keep good electric property under folding, distortion and stretching condition, thereby has improved the matching with heart.
Description of drawings
Fig. 1 is the structural representation of flexible visceral pericardium electrocardioelectrode chip among the embodiment;
Fig. 2 is the cutaway view along dotted line 6 shown in Figure 1;
Fig. 3 is the flow chart of flexible visceral pericardium electrocardioelectrode chip production method among the embodiment;
Fig. 4 is the flow chart of flexible visceral pericardium electrocardioelectrode chip production method among the embodiment 1;
Fig. 5 is the structural representation of flexible visceral pericardium electrocardioelectrode chip among the embodiment 2;
Fig. 6 is the cutaway view along dotted line 12 shown in Figure 5;
Fig. 7 is the application sketch map of flexible visceral pericardium electrocardioelectrode chip among the embodiment 2;
Fig. 8 is the flow chart of flexible visceral pericardium electrocardioelectrode chip production method among the embodiment 2.
The specific embodiment
For purpose of the present invention, feature and advantage can more be become apparent, below in conjunction with accompanying drawing the specific embodiment of the present invention is described in detail.
Embodiment 1:
Fig. 1 is the structural representation of flexible visceral pericardium electrocardioelectrode chip among the embodiment 1, and flexible visceral pericardium electrocardioelectrode chip comprises flexible substrates 1, insulating barrier 2, electrode unit 3, contact conductor 4 and lead-in wire junction point 5.Contact conductor 4 electrode electrically connected unit 3 and 5, one electrode units 3 of lead solder-joint, a contact conductor 4 and electrode assemblie of lead solder-joint 5 common compositions.Electrode assemblie is located on the flexible substrates 1, and insulating barrier 2 is located on the flexible substrates 1 and coated electrode lead-in wire 4.Electrode unit 3 is used for being electrically connected heart, and lead-in wire junction point 5 is used for realizing being connected of electrocardioelectrode and external circuit.Fig. 2 is the cutaway view along dotted line 6 shown in Figure 1, and in this embodiment, electrode unit 3 and lead-in wire junction point 5 expose to the open air in the external world, and insulating barrier is not established on the surface.Electrode unit quantity is 10, becomes the matrix distribution of 2*5.Understandable, the size of electrode unit 3, spacing, quantity can be adjusted based on the actual application requirements.The live width of contact conductor 4, spacing, cabling mode can be adjusted taking into full account under the rational situation of wiring.Size and the spacing of lead-in wire junction point 5 can be adjusted based on the actual application requirements.Lead-in wire junction point 5 is corresponding one by one with electrode unit 3, and quantity is identical.
The material of flexible substrates 1 and insulating barrier 2 is polydimethylsiloxane (polydimethylsiloxane).Polydimethylsiloxane has good pliability and deformability and excellent biological compatibility, and can guarantee machining accuracy and the spatial resolution of flexible visceral pericardium electrocardioelectrode chip.
Above-mentioned flexible visceral pericardium electrocardioelectrode chip is arranged by a plurality of electrode units 3 and is formed electrod-array, can realize minimum spatial resolution to micro-meter scale, have good pliability and deformability, can be attached to heart surface, adapt to the heart surface profile varying, can guarantee that electrode and heart surface target area form good attaching, can effectively avoid infringements such as the extruding that caused by electrode in the heart movement process and scuffing again.Can be used for the etiologic diagnosis of heart disease and focus is accurately located, for the specific aim treatment provides objective basis.
Fig. 3 is the flow chart of flexible visceral pericardium electrocardioelectrode chip production method among the embodiment, comprises the following steps:
S110 arranges polydimethylsiloxane in stiff base and forms flexible substrates 1.
Stiff base can be selected glass, silicon chip etc. for use, mainly plays a part to support.In the present embodiment, stiff base adopts silicon chip (can be any crystal orientation), and adopts the mode of spin coating that polydimethylsiloxane is arranged on silicon chip surface.The method that wherein changes flexible substrates 1 thickness mainly contains two kinds: a kind of is to change spin speed, and another is the concentration that changes polydimethylsiloxane.
S120 forms electrode unit 3, contact conductor 4 and lead-in wire junction point 5 in flexible substrates 1.
Adopt micro fabrication (comprising thin film preparation process, photoetching process, etching technics etc.) to make in flexible substrates 1.An electrode unit 3, a contact conductor 4 and a lead-in wire junction point 5 are formed an electrode assemblie, and contact conductor 4 is electrically connected electrode unit 3 and lead-in wire junction point 5.Among embodiment, electrode assemblie comprises electrode layer at least therein, and the material of electrode layer is a kind of in gold, titanium, the copper.Among embodiment, electrode assemblie also comprises prime coat therein, and electrode layer is located on the prime coat, and the material of prime coat is titanium, chromium, or comprises one or both the alloy in these two kinds of elements.Therein among embodiment, electrode unit 3 also comprises decorative layer, decorative layer is located at electrode unit 3 surface of flexible substrates 1 dorsad, the material of decorative layer is platinum, iridium, or comprise one or both alloy or chemical compound in these two kinds of elements, perhaps a kind of in polypyrrole, poly-(3,4-ethene dioxythiophene), the polyaniline.
S130, the polydimethylsiloxane that the coated electrode assembly is set in flexible substrates 1 forms insulating barrier 2, and forms opening in electrode unit 3 and lead-in wire junction point 5 positions of insulating barrier 2, and electrode unit 3 and lead-in wire junction point 5 are exposed.
Insulating barrier 2 can arrange by the method for spin coating equally, and the thickness of insulating barrier 2 also can be adjusted by the method that changes spin speed or change the concentration of polydimethylsiloxane.
S140 separates flexible substrates 1 from stiff base, obtain flexible visceral pericardium electrocardioelectrode chip.
Adopt the flexible nerve tract electrode of the preparation method preparation of above-mentioned flexible nerve tract electrode, have good size adaptability, be easy to realize the normalization design of device.
Flexible visceral pericardium electrocardioelectrode chip production method among a kind of embodiment 1 is provided again, referring to Fig. 4, comprises the following steps:
S210, spin coating one deck polydimethylsiloxane is as flexible substrates 1 on the silicon chip in any crystal orientation.
S220 prepares a mask, and the pierced pattern at mask formation electrode assemblie places mask on the flexible substrates 1, forms closely to attach.
S230 adopts the method for electron beam evaporation at first to deposit one deck titanium film as prime coat in flexible substrates 1, and then adopts the method for thermal evaporation to deposit one deck gold film as electrode layer at prime coat.
Prime coat and electrode layer are subjected to the pierced pattern restriction of mask, form the shape of electrode assemblie.
S240 removes mask.
S250 adopts thick type photoresist to carry out photoetching, prepares photoetching glue victim layer in the position of electrode unit 3 and the position of lead-in wire junction point 5.
S260, spin coating one deck polydimethylsiloxane is as insulating barrier 2.
Wherein the thickness of insulating barrier 2 should be far below the thickness of thick type photoetching glue victim layer.
S270 removes photoetching glue victim layer, forms the insulating barrier opening in the position of sacrifice layer, and the electrode assemblie of relevant position is come out.
S280 carries out finishing to electrode unit 3.
Namely plate one deck platinum black or yttrium oxide on the surface that electrode unit 3 exposes as decorative layer, to reduce impedance.
In other embodiments, the material of decorative layer can be platinum, iridium, or comprises one or both alloy or the chemical compound in these two kinds of elements, perhaps a kind of in polypyrrole, poly-(3,4-ethene dioxythiophene), the polyaniline.
Embodiment 2:
Fig. 5 is the structural representation of flexible visceral pericardium electrocardioelectrode chip among the embodiment 2, and flexible visceral pericardium electrocardioelectrode chip is made up of flexible substrates 7, insulating barrier 8, electrode unit 9, contact conductor 10 and lead-in wire junction point 11 5 parts equally.Among this embodiment with embodiment 1 in the electrode structure difference be that it has adopted a kind of stepped electrode structure, the stepped design of the thickness of flexible substrates 7.Though polydimethylsiloxane itself has the better elastic performance, its dynamic stretchable ability, pliability and attaching thereof are still closely bound up with its thickness.In order better to adapt to contraction and the diastole of heart, avoid visceral pericardium is produced damage, can carry out attenuate to the flexible substrates 7 that electrode paste is attached to the position (mainly concentrating on electrode unit array and part cabling zone) on the heart.Concrete, in one embodiment, be positioned at the thickness of flexible substrates 7 of electrode unit 9 belows much smaller than flexible substrates 7 other regional thickness, much smaller than referring generally to below 1/10th.In the present embodiment, electrode paste is attached to below the flexible substrates 7 μ m of local reduction to 5 of the position on the heart, and peripheral leads junction point 11 parts can remain on a thicker horizontal 50-500 μ m, can guarantee the flexibility of device like this, also guarantee the operability in its encapsulation and the operation process simultaneously.
In embodiment 2, the thickness that flexible substrates 7 is positioned at the part of lead-in wire junction point 11 belows is positioned at the thickness of part of the below of electrode unit 9 and contact conductor 10 much larger than flexible substrates 7, and the one side that flexible substrates 7 is provided with electrode assemblie is the plane.Fig. 6 is the cutaway view along dotted line 12 shown in Figure 5.Fig. 7 is that it uses sketch map, and comprising heart 13, lead 14, lead 14 are used for realizing being connected of lead-in wire junction point 11 and external circuit.
In embodiment 2, the cross section of flexible substrates 7 is rectangle, and electrode unit 9 and lead-in wire junction point 11 are corresponding one by one.Electrode assemblie comprises about axisymmetric two row of rectangular perpendicular bisector, the lead-in wire junction point 11 of electrode unit 9 and its correspondence is positioned at the same side of perpendicular bisector, electrode unit 9 is located at the position near perpendicular bisector, and corresponding lead-in wire junction point 11 is positioned at the position near rectangle one side parallel with perpendicular bisector.Flexible visceral pericardium electrocardioelectrode chip middle part forms inside depression in the one side of insulating barrier 8 dorsad.
Flexible visceral pericardium electrocardioelectrode chip production method among a kind of embodiment 2 is provided again, referring to Fig. 8, comprises the following steps:
S310 prepares the polydimethylsiloxane flexible substrates 7 that ledge structure is arranged in the substrate of glass that has boss structure.
Boss structure is the right angle boss in the present embodiment, also can be the oblique angle boss in other embodiments.
S320 adopts and peels off (lift-off) technology, the reversal photoresist pattern of the required electrode unit 9 of preparation, contact conductor 10 and lead-in wire junction point 11 on flexible substrates 7.
S330 adopts the mode of electron beam evaporation at flexible substrates 7 deposition layer of metal titanium films.
S340, remove photoresist and on metal titanium membrane, directly form needed electrode unit 9, contact conductor 10 and lead-in wire junction point 11.
S350, spin coating one deck polydimethylsiloxane is as insulating barrier 8 on the flexible substrates for preparing electrode unit 9, contact conductor 10 and lead-in wire junction point 11.
S360 adopts the method for cut to cut at electrode unit 9 and lead-in wire junction point 11 correspondence positions, removes the insulating barrier on electrode unit 9 and lead-in wire junction point 11 surfaces, realizes opening.
S370 carries out finishing to electrode unit 9.
Namely plate one deck platinum black or yttrium oxide on the surface that electrode unit 9 exposes as decorative layer, to reduce impedance.
Electrode chip as a kind of accurate measurement and observation analysis cardiac electrical activity, flexible visceral pericardium electrocardioelectrode chip is different with the routine electrocardiogram electrode, it can not only draw diagnosis on a macro scale, can also determine the exact position of pathological changes, can be the specific aim treatment objective basis, the curative effect that can also observe medicine more intuitively are provided.
Compared with prior art, the present invention has following useful effect:
1. this flexible visceral pericardium electrocardioelectrode chip adopts the material preparation that has good biocompatibility with organism, can use for a long time in vivo.
2. electrode chip adopts flexible material to make, more can adapt to the differently contoured of heart surface and can be with the heart motion synchronization telescope and not being shifted.
3. electrode chip adopts automatically and attaches, and has avoided being sewn to causing wound on the cardiac muscle and producing injury potential, influences the signals collecting precision.
4. the lead-in wire junction point adopts flexible design, guarantees that each electrode points contacts well with visceral pericardium, has avoided rigidity material electrode contacts to cause the phenomenon of switch-on and-off to occur.
5. electrode chip can change spatial resolution as required, disturbs for a short time, easy to use between the electrod-array, need not to sew up.
6. can be applied to the record chip pattern of different parts according to the cardiac structure design, but placement location is many, displacement rate is low, can not produce complication.
7. electrode chip still keeps good electric property under the condition that folds, twists and stretch, and has improved the operability of implanting, and reduces operation risk.
8. this electrode chip can also be used to observing intuitively curative effect of medication.
The above embodiment has only expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but can not therefore be interpreted as the restriction to claim of the present invention.Should be pointed out that for the person of ordinary skill of the art without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (10)
1. flexible visceral pericardium electrocardioelectrode chip, it is characterized in that, comprise: flexible substrates, electrode unit, contact conductor, lead-in wire junction point and insulating barrier, described electrode unit, contact conductor and lead-in wire junction point are formed electrode assemblie jointly, described electrode assemblie is located on the described flexible substrates, described electrode unit is connected to the lead-in wire junction point via contact conductor, realize being electrically connected, described insulating barrier is located on the described flexible substrates and is covered described contact conductor, described electrode unit is used for being electrically connected heart surface, and the material of described flexible substrates and insulating barrier is polydimethylsiloxane.
2. flexible visceral pericardium electrocardioelectrode chip according to claim 1 is characterized in that described electrode assemblie comprises electrode layer, and the material of described electrode layer is a kind of in gold, titanium, the copper.
3. flexible visceral pericardium electrocardioelectrode chip according to claim 2, it is characterized in that described electrode assemblie also comprises prime coat, described electrode layer is located on the described prime coat, the material of described prime coat is titanium, chromium, or comprises one or both the alloy in these two kinds of elements.
4. according to claim 2 or 3 described flexible visceral pericardium electrocardioelectrode chips, it is characterized in that, described electrode unit also comprises decorative layer, described decorative layer is located at the electrode unit surface of described flexible substrates dorsad, the material of described decorative layer is platinum, iridium, or comprise one or both alloy or chemical compound in these two kinds of elements, perhaps a kind of in polypyrrole, poly-(3,4-ethene dioxythiophene), the polyaniline.
5. flexible visceral pericardium electrocardioelectrode chip according to claim 1 is characterized in that, described flexible substrates is positioned at the thickness of electrode unit part much smaller than other regional thickness of flexible substrates.
6. flexible visceral pericardium electrocardioelectrode chip according to claim 5, it is characterized in that, the cross section of described flexible substrates is rectangle, described electrode unit and lead-in wire junction point are corresponding one by one, described electrode assemblie comprises about axisymmetric two row of described rectangular perpendicular bisector, described electrode unit and corresponding lead-in wire junction point are positioned at the same side of perpendicular bisector, described electrode unit is located at the position near described perpendicular bisector, corresponding lead-in wire junction point is positioned at the position near rectangle one side parallel with described perpendicular bisector, forms inside depression in the one side of described insulating barrier dorsad in the middle part of the described flexible visceral pericardium electrocardioelectrode chip.
7. a flexible visceral pericardium electrocardioelectrode chip production method comprises the following steps:
Step 1 arranges polydimethylsiloxane in stiff base and forms flexible substrates;
Step 2 forms electrode assemblie in described flexible substrates, and described electrode assemblie comprises the lead-in wire junction point, is used for being electrically connected the electrode unit of heart surface, reaches the contact conductor that is electrically connected described lead-in wire junction point and electrode unit;
Step 3 arranges the polydimethylsiloxane that covers described electrode assemblie in described flexible substrates and forms insulating barrier, and forms opening in electrode unit and the lead-in wire junction point position of described insulating barrier, exposes described electrode unit and lead-in wire junction point;
Step 4 is separated described flexible substrates from stiff base, obtain described flexible visceral pericardium electrocardioelectrode chip.
8. flexible visceral pericardium electrocardioelectrode chip production method according to claim 7 is characterized in that described step 2 comprises:
Prepare a mask that is formed with the pierced pattern of described electrode assemblie shape;
Described mask is adhere well on the described flexible substrates;
Be pasted with deposit prime coat on the flexible substrates of described mask;
Deposit one deck electrode layer on described prime coat;
Described mask is removed on flexible substrates.
9. flexible visceral pericardium electrocardioelectrode chip production method according to claim 7, it is characterized in that, also be included in the step of described electrode unit surface plating one deck decorative layer after the described step 3, the material of described decorative layer is platinum, iridium, or comprise one or both alloy or chemical compound in these two kinds of elements, perhaps a kind of in polypyrrole, poly-(3,4-ethene dioxythiophene), the polyaniline.
10. flexible visceral pericardium electrocardioelectrode chip production method according to claim 7 is characterized in that described stiff base is the glass boss.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310082091.3A CN103202690B (en) | 2013-03-14 | 2013-03-14 | Flexible epicardium electrocardio-electrode chip and preparation method thereof |
| PCT/CN2013/074306 WO2014139194A1 (en) | 2013-03-14 | 2013-04-17 | Flexible epicardial ecg electrode chip and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310082091.3A CN103202690B (en) | 2013-03-14 | 2013-03-14 | Flexible epicardium electrocardio-electrode chip and preparation method thereof |
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| Publication Number | Publication Date |
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| CN103202690A true CN103202690A (en) | 2013-07-17 |
| CN103202690B CN103202690B (en) | 2015-04-15 |
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| CN103462601A (en) * | 2013-09-24 | 2013-12-25 | 深圳先进技术研究院 | Medical electrode plaster and preparation method thereof |
| CN104095628A (en) * | 2014-07-04 | 2014-10-15 | 李若斌 | Flexible medical electrode, medical electrode sheet, detecting instrument, treatment instrument and application |
| CN104739403A (en) * | 2015-04-10 | 2015-07-01 | 中国科学院重庆绿色智能技术研究院 | Graphene nanowall flexible electrocardio-electrode and preparation method thereof |
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| CN106799538B (en) * | 2016-12-09 | 2019-11-01 | 上海交通大学 | A kind of hot pressing connects method of flexibility soft arranging wire and Parylene flexible electrode |
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Also Published As
| Publication number | Publication date |
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| WO2014139194A1 (en) | 2014-09-18 |
| CN103202690B (en) | 2015-04-15 |
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