CN103055364A - Bubble monitoring device for portable blood purification system - Google Patents
Bubble monitoring device for portable blood purification system Download PDFInfo
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- CN103055364A CN103055364A CN2013100203143A CN201310020314A CN103055364A CN 103055364 A CN103055364 A CN 103055364A CN 2013100203143 A CN2013100203143 A CN 2013100203143A CN 201310020314 A CN201310020314 A CN 201310020314A CN 103055364 A CN103055364 A CN 103055364A
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Abstract
The invention discloses a bubble monitoring device for a portable blood purification system. The monitoring device mainly comprises an ultrasonic bubble detector which comprises an ultrasonic transmitting device and an ultrasonic receiving device. The monitoring device functions through steps as follows: (1) acquiring the regular rectangular signal pulse width by processing the ultrasonic pulse signal detected by the receiving device through the signal processing module; (2) comparing the pulse width of the signal Tc and the set threshold by the comparator, large bubble threshold is Tc1, no bubbles and micro bubbles threshold is Tc0. When Tc >/= Tc1, the bubbles directly enter the CPU processor and start the alarming device; when Tc </=Tc0, the bubbles are directly filtered out; when Tc0 <Tc <Tc1, the bubbles enter the CPU processor and be cumulated, when the cumulative amount per minute is greater than the set value T, the alarming device is triggered. The reliability of the bubble monitoring device is greatly enhanced, timely and accurate warning of the bubble is guaranteed, and various disturbances are also effectively avoided.
Description
Technical field
The present invention relates to a kind of bubble monitoring device, especially a kind of bubble monitoring device that under the condition of the open-air battlefield of rocking vibration, is used for Portable blood purifying system.
Background technology
Bubble detector is as the main detection means on the present dialysis machine, Main Function is whether the venous return section that detects in real time, continuously, reliably in whole dialysis procedure at blood extracorporeal circulation has bubble to exist, preventing that gas from entering causes gas embolism in the patient body, guarantee the safety of dialysis patient.When having air to occur, machine sends alarm signal, makes the blood clip closure, stops in the blood flowing patient body.
General detection method commonly used has three kinds: (1) condenser type detector; (2) infrared electro formula detector; (3) ultrasonic type detector.Because ultrasonic detector has strong penetration capacity, strong anti-interference ability, reliability is high, the characteristics such as attenuation degree is obvious in liquids and gases, the most easily realize with the bubble in its principle tracer liquid pipeline, and highly sensitive, reliable and stable, can also detect the very little continuous minute bubbles in gap, therefore select ultrasonic detector as gas bubble detection.
Detect principle: utilize sound wave can reflect and refraction at the interface of different medium, conduction is affected, intensity of sound will significantly reduce.
Acoustical signal is inner at bubble-free liquid (blood), and attenuation rate is very little, and most of received device receives; The larger output voltage signal of receiving intensity is also larger.In case have bubble to exist in the liquid, most of acoustic signals will be reflected by bubble and reflect, signal is significantly decayed, and the intensity of sound that this moment, receptor received will reduce, and output voltage signal also diminishes thereupon.The degree that output voltage signal diminishes can reflect the size of bubble volume.The bubble that volume is larger (perhaps more consubstantiality pneumatosis bubble) causes that the change of voltage is larger.
The structure diagram of Ultrasonic Wave Air Detector as shown in Figure 1, discharger 1 and receiving system 2 are installed in the both sides of blood catheter 3, detect principle as shown in Figure 2.
The bubble detection head is installed in blood circuit, employing be the transmission ultrasonic wave detection method, in the both sides of blood catheter ultrasonic emitting and receiving system are housed respectively.During without bubble, ultrasound wave arrives the test side by medium blood, and the loss of sound wave is little, when being converted to the signal of telecommunication through transducer, can see clearly that with oscillograph frequency is the sine wave of 1MHz, this signal is made a gift to someone logic circuit after treatment to guarantee the normal operation of loom on circuit board; When bubble occurring in the blood, because the sound wave major part is reflected, almost there is not so sound wave in the test side, be reflected on the circuit then is that original signal of telecommunication has not had, become low level, this variation will make the logic circuit level that corresponding upset occurs, and the control machine sends sound and light alarm and makes the blood clip closure, simultaneously blood pump stall stops bubble to advance people's human body with backflow blood and causes that thromboembolism jeopardizes patients ' lives safety.
There is following defective in existing bubble detecting method:
First, the detection threshold of existing air bubble sensor is generally demarcated when sensor dispatches from the factory, one has bubble then to report to the police immediately in blood, very sensitive, but this has just caused certain defective for portable dialysis machine, because the purpose of portable dialysis machine design designs for treatment in the open air or in the motion, in the middle of instrument often is in and rocks, at this moment understand the small bubble of continuous output in the blood, and move along with blood flow, like this with regard to the continuous warning that caused air bubble sensor and can't use;
The second, because rocking of instrument can produce a lot of interfering signals, also can affect the normal applicable of sensor.
Summary of the invention
The problem of constantly reporting to the police at the volley for the air bubble sensor that improves portable dialysis machine, and reach protection patient's purpose, the present invention has introduced signal processing module, comparator and CPU processor.
The invention provides a kind of bubble monitoring device for Portable blood purifying system, mainly formed by ultrasonic bubble detector, ultrasonic bubble detector comprises that ultrasonic transmission device and receiving system form, (1) ultrasonic pulse signal that detects by receiving system is processed through signal processing module, obtains the rectangular signal pulsewidth of rule; (2) compare by the threshold values of comparator to signal pulsewidth Tc and setting, the air pocket threshold values is Tc1, is Tc0 without bubble and micro bubble threshold values, as Tc 〉=Tc1, directly enters the CPU processor and starts alarm device; When Tc≤Tc0, Direct Filtration is fallen; When Tc0＜Tc＜Tc1, enter the CPU processor and accumulate calculating, when the cumulant of per minute starts alarm device during greater than setting value T.
Preferred scheme is that threshold values Tc1 is 20-100ul, and Tc0 is 5-20ul, and Tc1＞Tc0.
Preferred scheme is 1-3ml/ minute for setting value T.
Preferred scheme is for also comprising active bandwidth-limited circuit, Schmidt trigger and comparator.
Preferred scheme is for also comprising the interfering signal processing module, and the interfering signal processing module adopts digital filtering mode, the way elimination interfering signal of averaging of repeatedly sampling.
Ultrasonic bubble detector is installed in the blood circuit, employing be the transmission ultrasonic wave detection method.Ultrasonic transmission device and receiving system are equipped with respectively in both sides at blood catheter.In the liquid proper flow and when not sneaking into bubble, the loss of sound wave is little, and the amplitude of the ultrasonic pulse signal that detects at receiving terminal should be enough large, and signal signal pulsewidth behind Shape correction is wide; When bubble occurring in the blood because the sound wave major part is reflected, the amplitude of the ultrasonic pulse signal that detects at receiving terminal so this bubble during by the sensor detection faces decay larger, signal signal pulsewidth behind Shape correction narrows down.Bubble is larger, and pulsewidth is narrower.
For making bubble monitoring device more reliable, not only can send warning to the bubble more than the certain volume, can detect simultaneously the volume of the following bubble of this volume and estimation bubble, and with this volume accumulative total, when the micro-bubble cumulative volume accumulative total that is not enough to cause warning of bubble monitoring device surpasses certain value in case flow through in dialysis procedure, also can report to the police the potential safety hazard that the prompting staff exists.
Suppose that pulse width is Tc, pulse width is Tc1 when setting under the certain volume air pocket, and pulse width is Tc0 when without bubble and during micro bubble.
When Tc＞=Tc1, show to belong to the large volume bubble, report to the police and dispose therefore produce;
When Tc＜Tc0, belong to micro-minute bubbles, can not produce injury to human body, therefore do not need to report to the police;
When Tc1＜Tc＜Tc0, belong to the small size bubble, when this type bubble is accumulated to a certain degree, also can damage human body, therefore also need to report to the police and dispose.
In actual use, air pocket threshold values Tc0 generally can be set as 20-100ul, minute bubbles threshold values Tc1 is set as between the 5-20ul adjustable, minute bubbles accumulative total threshold value setting is 1-3ml/ minute, by adjusting the setting of threshold values, can change the sensitivity of instrument, according to patient's practical situation, be set the size of threshold values by the technician.
Because rocking of instrument can produce a lot of interfering signals, also can affect the normal applicable of sensor, therefore, also should be eliminated this type of interfering signal, interfering signal generally mostly is high frequency small-signal (as shown in Figure 5), is eliminated from hardware and software two aspects this interfering signal is many.Hardware aspect has increased the devices such as active bandpass filiter circuit, Schmidt trigger, comparator in the signal processing link.The software aspect has adopted digital filtering mode, the way of averaging of repeatedly sampling.By the improvement of hardware and software two aspects, thereby effectively eliminated the interference of interfering signal.
The reliability of bubble monitoring device of the present invention has obtained greatly strengthening, and is especially waving, vibrate under the condition of open-air battlefield, very obvious with the difference of former bubble sensor, namely guaranteed the promptly and accurately warning of bubble, effectively shielded again various interference.
Description of drawings
Fig. 1 is the structural representation of Ultrasonic Wave Air Detector in the background technology of the present invention;
Fig. 2 is the detection schematic diagram of Ultrasonic Wave Air Detector in the background technology of the present invention;
Fig. 3 is detection principle schematic of the present invention;
Fig. 4 is not for adding the pressure history figure when entering the liquid surge tank of the present invention;
Fig. 5 adds the pressure history figure when entering the liquid surge tank of the present invention.
The specific embodiment
Below in conjunction with the drawings and the specific embodiments, the present invention is further detailed explanation, but the protection domain that this specific embodiment is not intended to limit the present invention.
Embodiment 1:
The invention provides a kind of bubble monitoring device for Portable blood purifying system, mainly formed by ultrasonic bubble detector, ultrasonic bubble detector comprises that ultrasonic transmission device and receiving system form, (1) ultrasonic pulse signal that detects by receiving system is processed through signal processing module, obtains the rectangular signal pulsewidth of rule; (2) compare by the threshold values of comparator to signal pulsewidth Tc and setting, the air pocket threshold values is Tc1, is Tc0 without bubble and micro bubble threshold values, as Tc 〉=Tc1, directly enters the CPU processor and starts alarm device; When Tc≤Tc0, Direct Filtration is fallen; When Tc0＜Tc＜Tc1, enter the CPU processor and accumulate calculating, when the cumulant of per minute starts alarm device during greater than setting value T, threshold values Tc1 is 20-100ul, and Tc0 is 5-20ul, and Tc1＞Tc0, and setting value T is 1-3ml/ minute.Also comprise active bandwidth-limited circuit, Schmidt trigger and comparator and interfering signal processing module, the interfering signal processing module adopts digital filtering mode, the way elimination interfering signal of averaging of repeatedly sampling.
Embodiment 2 the present invention detect test
The present invention is carried out vehicle-mounted dialysis test, in the situation that Vehicle Driving Cycle carries out.
Subjects: Canis familiaris L., 23 kilograms of body weight
Test parameters: blood flow is set 300ml/ minute; Fluid infusion velocity is set 1 l/h; Dewatering speed is set 0.2 l/h; Dialysis time is set 5 hours.
In test, adopt original Ultrasonic Wave Air Detector, in 5 hours, former bubble sensor is reported to the police constantly, and common property has been given birth to hundreds of times and reported to the police, and has greatly disturbed the carrying out of dialysis.
Under same condition, adopt device of the present invention, common property is given birth to air pocket and is reported to the police 5 times, and the accumulative total bubble is reported to the police 3 times.
According to the result of the test that obtains, 6 experiments have been done again by project team, experimental result all shows: the reliability of the ultrasonic bubble detector monitoring after the improvement has obtained greatly strengthening, especially waving, vibrating under the condition of open-air battlefield, very obvious with the difference of former bubble sensor, namely guarantee the promptly and accurately warning of bubble, effectively shielded again various interference.The present invention can in Portable blood purifying system, greatly improve the function of existing air bubble sensor.
Above content be in conjunction with structure of the present invention and work process to its further description of doing, can not assert that implementation of the present invention is confined to these explanations.For the general technical staff of the technical field of the invention, without departing from the inventive concept of the premise, can also make some simple deduction or replace, all should be considered as belonging to protection scope of the present invention.
Claims (5)
1. bubble monitoring device that is used for Portable blood purifying system, mainly formed by ultrasonic bubble detector, ultrasonic bubble detector comprises that ultrasonic transmission device and receiving system form, it is characterized in that: process through signal processing module by the ultrasonic pulse signal that receiving system detects (1), obtains the rectangular signal pulsewidth of rule; (2) compare by the threshold values of comparator to signal pulsewidth Tc and setting, the air pocket threshold values is Tc1, is Tc0 without bubble and micro bubble threshold values, as Tc 〉=Tc1, directly enters the CPU processor and starts alarm device; When Tc≤Tc0, Direct Filtration is fallen; When Tc0＜Tc＜Tc1, enter the CPU processor and accumulate calculating, when the cumulant of per minute starts alarm device during greater than setting value T.
2. the bubble monitoring device for Portable blood purifying system according to claim 1, it is characterized in that: described threshold values Tc1 is 20-100ul, Tc0 is 5-20ul, and Tc1＞Tc0.
3. the bubble monitoring device for Portable blood purifying system according to claim 1 and 2, it is characterized in that: described setting value T is 1-3ml/ minute.
4. the bubble monitoring device for Portable blood purifying system according to claim 1 and 2 is characterized in that: also comprise active bandwidth-limited circuit, Schmidt trigger and comparator.
5. the bubble monitoring device for Portable blood purifying system according to claim 4, it is characterized in that: also comprise the interfering signal processing module, the interfering signal processing module adopts digital filtering mode, the way elimination interfering signal of averaging of repeatedly sampling.
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| CN2013100203143A CN103055364A (en) | 2013-01-21 | 2013-01-21 | Bubble monitoring device for portable blood purification system |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105688303A (en) * | 2016-01-15 | 2016-06-22 | 北京大德海纳医疗科技有限公司 | Portable blood purifying system bubble monitoring device and method |
| CN105983148A (en) * | 2015-03-17 | 2016-10-05 | B·布莱恩·阿维图姆股份公司 | Gas bubble and/or solid object detector based on ultrasound, dialysis device and method for such a detector |
| CN108132299A (en) * | 2018-03-06 | 2018-06-08 | 杭州森威传感科技有限公司 | A kind of air bubble sensor and method for bubble in signal piping |
| CN108175909A (en) * | 2018-01-29 | 2018-06-19 | 英华达（上海）科技有限公司 | Ultrasonic bubble detection method and system |
| CN111905174A (en) * | 2020-08-07 | 2020-11-10 | 成都威力生生物科技有限公司 | Dialysis pipeline bubble detection circuit |
| CN114306825A (en) * | 2021-12-28 | 2022-04-12 | 安徽皖仪科技股份有限公司 | Blood bubble monitoring module and method |
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| US4487601A (en) * | 1983-06-20 | 1984-12-11 | Extracorporeal Medical Specialties, Inc. | Bubble detector circuit with variable reference level |
| US4651555A (en) * | 1984-09-11 | 1987-03-24 | Introtek Corporation | Apparatus for detecting discontinuities in a fluid stream |
| US5394732A (en) * | 1993-09-10 | 1995-03-07 | Cobe Laboratories, Inc. | Method and apparatus for ultrasonic detection of air bubbles |
| CN101189509A (en) * | 2005-06-03 | 2008-05-28 | 弗雷泽纽斯医疗保健德国有限公司 | Method and device for monitoring a flow of liquid for the presence of air by means of ultrasound |
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2013
- 2013-01-21 CN CN2013100203143A patent/CN103055364A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US4487601A (en) * | 1983-06-20 | 1984-12-11 | Extracorporeal Medical Specialties, Inc. | Bubble detector circuit with variable reference level |
| US4651555A (en) * | 1984-09-11 | 1987-03-24 | Introtek Corporation | Apparatus for detecting discontinuities in a fluid stream |
| US5394732A (en) * | 1993-09-10 | 1995-03-07 | Cobe Laboratories, Inc. | Method and apparatus for ultrasonic detection of air bubbles |
| CN101189509A (en) * | 2005-06-03 | 2008-05-28 | 弗雷泽纽斯医疗保健德国有限公司 | Method and device for monitoring a flow of liquid for the presence of air by means of ultrasound |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105983148A (en) * | 2015-03-17 | 2016-10-05 | B·布莱恩·阿维图姆股份公司 | Gas bubble and/or solid object detector based on ultrasound, dialysis device and method for such a detector |
| CN105688303A (en) * | 2016-01-15 | 2016-06-22 | 北京大德海纳医疗科技有限公司 | Portable blood purifying system bubble monitoring device and method |
| CN108175909A (en) * | 2018-01-29 | 2018-06-19 | 英华达（上海）科技有限公司 | Ultrasonic bubble detection method and system |
| CN108132299A (en) * | 2018-03-06 | 2018-06-08 | 杭州森威传感科技有限公司 | A kind of air bubble sensor and method for bubble in signal piping |
| CN111905174A (en) * | 2020-08-07 | 2020-11-10 | 成都威力生生物科技有限公司 | Dialysis pipeline bubble detection circuit |
| CN114306825A (en) * | 2021-12-28 | 2022-04-12 | 安徽皖仪科技股份有限公司 | Blood bubble monitoring module and method |
| CN114306825B (en) * | 2021-12-28 | 2024-02-09 | 安徽皖仪科技股份有限公司 | Blood bubble monitoring module |
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Application publication date: 20130424 |