CN102989055A - Fluid delivery system with multi-dose fluid source - Google Patents

Fluid delivery system with multi-dose fluid source Download PDF

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Publication number
CN102989055A
CN102989055A CN2012104424174A CN201210442417A CN102989055A CN 102989055 A CN102989055 A CN 102989055A CN 2012104424174 A CN2012104424174 A CN 2012104424174A CN 201210442417 A CN201210442417 A CN 201210442417A CN 102989055 A CN102989055 A CN 102989055A
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CN
China
Prior art keywords
fluid
syringe
container
target
delivery system
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Granted
Application number
CN2012104424174A
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Chinese (zh)
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CN102989055B (en
Inventor
罗宾.C.科克尔
保罗.A.约翰逊
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Liebel Flarsheim Co LLC
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Mallinckrodt Inc
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Publication of CN102989055A publication Critical patent/CN102989055A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/315Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14546Front-loading type injectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16804Flow controllers
    • A61M5/16827Flow controllers controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/54Control of apparatus or devices for radiation diagnosis
    • A61B6/548Remote control of the apparatus or devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14546Front-loading type injectors
    • A61M2005/14553Front-loading type injectors comprising a pressure jacket
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M2005/3117Means preventing contamination of the medicament compartment of a syringe
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M2005/3128Incorporating one-way valves, e.g. pressure-relief or non-return valves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/007Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests for contrast media

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)

Abstract

A fluid delivery system (400A) is generally directed to allowing fluid sources or other fluid delivery components to be reused with multiple fluid targets (318), and includes at least one fluid source (314) fluidly interconnectable with at least one sterilization zone (316) and at least one fluid target (318). This sterilization zone (316) could include one or more sterilization systems that attempt to neutralize contaminants entering the fluid delivery system (400A) by a backflow from the fluid target (318). One such sterilization system (500A-D) includes a container (502a-d) and a flush system (520) for sterilizing the container (502a-d) between uses. Another sterilization system (600) includes a flowpath (604) exposed to an output of an energy source (602) capable of destroying contaminants. Yet another sterilization system could include a sterilizing substance (710) that engages and moves along an interior surface (705) of a housing (704) to treat contamination thereon.

Description

Fluid delivery system with multi-dose fluid source
The application is that denomination of invention is " fluid delivery system with multi-dose fluid source ", the applying date to be that November 19, application number in 2008 are dividing an application of 200880116756.5 application for a patent for invention.
The cross reference of related application
It is No.60/988 that the application requires serial number according to 35U.S.C.119 (e), the priority of 858 U.S. Provisional Patent Application, this U.S. Provisional Patent Application are called " FLUID DELIVERY SYSTEMWITH MULTI-DOSE FLUID SOURCE " and submit on November 19th, 2007.
Technical field
The present invention relates generally to the field of fluid delivery system, and relates more specifically to one or more sterilising zones are incorporated in the fluid delivery system that utilizes multiple dose (multi-dose) fluid source.
Background technology
Medical contrast medium is quite expensive product.The syringe that factory is pre-filled or tubule (vial) can be used for each contrast agent dosage is transported to makes land used.In this case, after injection process, usually can be left a certain amount of contrast agent (for example, based on the difference between the patient, the difference between the imaging demand, or both of these case has).Any remaining contrast agent all can be processed as refuse usually.Be proposed the large volume storage capsule that uses contrast agent, it can be used for providing contrast agent for a plurality of injection process.Because contrast agent may be medicine outside the intestinal, and owing to when being connected with patient's fluid ground, pollution can be incorporated in the fluid delivery system, so when using the multiple dose source of contrast to be used for a plurality of patient, should note sterilization.
Summary of the invention
The present invention relates generally to the sterilizing function that provides relevant with FLUID TRANSPORTATION.The first and second aspects of the present invention relate generally to and utilize energy source output that sterilizing function is provided.The third and fourth aspect of the present invention relates generally to utilization intermediate cavity or container in somewhere between fluid source and fluid target sterilizing function is provided.The the of the present invention the 5th and the 6th aspect relates generally to " wiping sweeps works " of utilizing the surface be exposed to fluid etc. sterilizing function is provided, and wherein, this surface is exposed to the fluid that will be fed to the patient, and wipes and sweep work and provide by disinfectant member or medium.Each will discuss in detail these aspects hereinafter.
A first aspect of the present invention realizes by a kind of fluid delivery system, comprising: fluid reservoir; Syringe and energy source.The first flow path extends to fluid target from described fluid source.Syringe interconnects with the described first mobile path flow body ground at least.At least a portion of the first flow path is exposed to the output from described energy source.This exposure is used to reduce at least the pollution level (for example, reducing pollutant are retracted fluid reservoir and/or syringe from fluid target probability) by the fluid of the first flow path.
Existence is about the various improvement of the described feature of first aspect present invention.Further feature also can be incorporated in the above-mentioned first aspect of the present invention.These improvement and additional feature can be individually or are existed with the form of any combination.Until the following description before the second aspect present invention all belongs to this first aspect.
The first flow path can limit in any suitable manner, for example the form of at least one conduit or the form that otherwise limited by at least one conduit.Each conduit can have any suitable size, shape, structure and/or type (for example, medical pipeline).In one embodiment, the first flow path comprises by any way removably the first and second duct portions of interconnection, the first duct portion extends to fluid target from described the second duct portion, and the first duct portion has disposable form, and the second duct portion can be reused for a plurality of fluid delivery process (for example, using with a plurality of fluid targets).At least a portion of described the first duct portion is exposed under the output of energy source.
Energy source can have any suitable size, shape, structure and/or type.An embodiment has the energy source of heater form.Another embodiment is the energy source with radiation source form, and this radiation source is with one or more wavelength emission radiation.The first duct portion at least about 5 inches or 13 centimetres is exposed to from also can further reducing pollutant are retracted fluid reservoir and/or syringe by fluid delivery system from fluid target probability under the output of energy source.
A second aspect of the present invention realizes by a kind of method for delivery of fluid.Flow path extends to the first fluid target from fluid reservoir.Fluid storage is in fluid reservoir, and at least some of this fluid are from fluid reservoir discharging or discharge.Be transported to the first fluid target from the fluid of the first dosage of fluid reservoir discharging via above-mentioned flow path.At least a portion of flow path is exposed under the energy source output (for example, reducing pollutant are retracted fluid reservoir and/or syringe from fluid target probability).
Existence is about the various improvement of the described feature of second aspect present invention.Further feature also can be incorporated in the above-mentioned second aspect of the present invention.These improvement and additional feature can be individually or are existed with the form of any combination.Until the following description before the third aspect present invention all belongs to this second aspect.The output of energy source can be the combination of any suitable type or type.The output that allows at least a portion of flow path be exposed to the energy source under it can have the form (for example, gamma radiation) of radiation.Can use the radiation (for example, ultraviolet light, infrared light) of any suitable wavelength or wavelength combinations.Also can use hotwork to export as energy source, this heat produces with any appropriate format.Embodiment requires the temperature of the fluid heating in the expose portion of flow path to about at least 104 ℉ or 40 ℃.
The length that is exposed to the flow path under the energy source output can be selected as further reducing pollutant arrive fluid reservoir by exposed region probability.In one embodiment, one or more aspects of energy source output (for example, dosage or close rate (dose rate)), and the length that is exposed to the flow path under the energy source output can be selected as obviously reducing pollutant arrive fluid reservoir by exposed region probability.In one embodiment, the length that is exposed to the flow path under the energy source output is approximately 5 inches or 13 centimetres at least.
Be that with one of them relevant under at least a portion with flow path is exposed to energy source output benefit fluid reservoir can hold the fluid of sufficient quantity, in order to can be used for a plurality of fluid targets and/or a plurality of fluid delivery process.In one embodiment, the first fluid target disconnects (for example, entity ground and/or fluid ground) from fluid reservoir.At least some fluids in fluid reservoir are from fluid reservoir discharging or release.The second fluid target is connected to fluid reservoir.The fluid from the second dosage of fluid reservoir discharging is transported to the second fluid target.For the FLUID TRANSPORTATION of the second dosage can be used any suitable order to the second fluid target.For example, disconnect (for example, entity ground and/or fluid ground) afterwards from fluid reservoir in the first fluid target, the fluid of the second dosage can or discharge from the fluid reservoir discharging.After fluid reservoir disconnects, the second fluid target can be connected to fluid reservoir in the first fluid target.
A third aspect of the present invention can realize by a kind of fluid delivery system, comprise: fluid reservoir; The first container; Syringe; And rinse-system, wherein, described syringe is not the part of described rinse-system.The first container can with described fluid reservoir fluid ground interconnection, syringe can with described fluid reservoir and described the first container at least one fluid ground interconnection, and rinse-system can interconnect with described the first fluid container ground.Syringe is operating as by conduit guide of flow is arrived fluid target.
Existence is about the various improvement of the described feature of third aspect present invention.Further feature also can be incorporated in the above-mentioned third aspect of the present invention.These improvement and additional feature can be individually or are existed with the form of any combination.Until the following description before the fourth aspect present invention all belongs to this third aspect.Rinse-system has the form of flushing source and flushing receptor, and each can have any suitable size, shape, structure and/or type flushing source and flushing receptor.For example, a kind of scouring media can be used in the flushing source, or the combination of the two or more scouring medias of any appropriate format, and wherein, every kind of scouring media provides any suitable function or function combinations (for example, sterilization).Representational scouring media includes but not limited to ethanol, steam, ETO(oxirane), fluids for sterilization, water, air, noble gas, noble gas combination, bleach, hydrogen peroxide, oxygen and its any combination.The flushing receptor can have the form of any appropriate containers, storage vessel etc., or can have simply the form of discharge portion etc.
Fluid reservoir can with the first container in any suitable manner optionally fluid ground interconnection and with this first fluid container isolation.The first container can with the flushing source in any suitable manner optionally fluid ground interconnection and with this flushing source fluid isolation.Fluid target can with the first container in any suitable manner optionally fluid ground interconnection and with this first fluid container isolation.The flushing receptor can with the in any suitable manner optionally fluid ground interconnection and isolate with this first fluid container of the first container.For example, can use one or more valves (for example, check valve, choke valve, the family of power and influence, electromagnetic valve), flow control apparatus etc. for the expectation " state " that between above-mentioned paired structure, provides fluid to be communicated with.
Exist and be used for scouring media is directed to a plurality of structures that the neutralization of the first container is guided out the first container (for example, so that sterilizing function to be provided).As mentioned above, rinse-system can be integrated with fluid delivery system in every way.The representativeness of rinse-system now will be discussed to be integrated.
In the first embodiment, the first container comprises the first entrance and the first outlet, and wherein, each can interconnect described fluid reservoir and described flushing source with the first inlet fluid ground, and wherein, described fluid target and described flushing receptor each can interconnect with the first outlet fluid ground.The two can interconnect fluid reservoir and flushing source by the first entrance entity ground with the first container, but also can be connected (for example, via one or more valves, flow control apparatus etc.) with the isolation of the first fluid container or fluid ground.The first entrance also can disconnect with described fluid reservoir entity ground and be connected with flushing source entity ground, and with difference fluid isolation and these structures of fluid ground interconnection, vice versa.Similarly, the two keeps the interconnection of entity ground by the first outlet and the first container fluid target and flushing receptor, but also can be connected (for example, via one or more valves, flow control apparatus etc.) with the isolation of the first fluid container or fluid ground.The first outlet also can disconnect with described fluid target entity ground and be connected with flushing receptor entity ground, and with difference fluid isolation and these structures of fluid ground interconnection, vice versa.Each can interconnect fluid reservoir, fluid target, flushing source and flushing receptor and fluid isolation with the first fluid container ground in any suitable manner.Under any circumstance, at least a scouring media can be directed to the first container by the first entrance from the flushing source, and the isolation of fluid reservoir and fluid target each and the first fluid container.Scouring media can by the first outlets direct go out the first container and be directed to the flushing receptor in, and fluid reservoir and fluid target each can isolate with the first fluid container.
In a second embodiment, the first container comprises the first and second entrances, and the first outlet.The first entrance can interconnect with fluid reservoir fluid ground, and the second entrance can interconnect with flushing source fluid ground.The two can interconnect fluid target and flushing receptor with the first outlet fluid ground.Described fluid target and described flushing receptor can keep the interconnection of entity ground by the first outlet with the first container, but also can be connected (for example, via one or more valves, flow control apparatus etc.) with the isolation of the first fluid container or fluid.The first outlet also can disconnect with described fluid target entity ground and be connected with flushing receptor entity ground, and with difference fluid isolation and these structures of fluid ground interconnection, vice versa.Each can interconnect fluid reservoir, fluid target, flushing source and flushing receptor and fluid isolation with the first fluid container ground in any suitable manner.Under any circumstance, at least a scouring media can be directed to the first container by the second entrance from the flushing source, and fluid reservoir and fluid target each can isolate with the first fluid container.Scouring media can by the first outlets direct go out the first container and be directed to the flushing receptor in, and fluid reservoir and fluid target each can isolate with the first fluid container.
In the 3rd embodiment, the first container comprises the first and second entrances, and the first and second outlets.The first entrance can interconnect with fluid reservoir fluid ground, and the second entrance can interconnect with flushing source fluid ground.The first outlet can interconnect with fluid target fluid ground, and the second outlet can interconnect with flushing receptor fluid ground.The second entrance and the second exporting features are rinse mouth.Each can interconnect fluid reservoir, fluid target, flushing source and flushing receptor and fluid isolation with the first fluid container ground in any suitable manner.Under any circumstance, at least a scouring media can be directed to the first container by the second entrance from the flushing source, and the isolation of fluid reservoir and fluid target each and the first fluid container.Scouring media can by the second outlets direct go out the first container and be directed to the flushing receptor in, and fluid reservoir and fluid target each can isolate with the first fluid container.
In the 4th embodiment, the first container comprises the first entrance, the first outlet and rinse mouth, wherein, fluid reservoir can interconnect with the first inlet fluid ground, wherein, fluid target can interconnect with the first outlet fluid ground, and each can interconnect flushing source and flushing receptor with rinse mouth fluid ground.Each can interconnect fluid reservoir, fluid target, flushing source and flushing receptor and fluid isolation with the first fluid container ground in any suitable manner.Under any circumstance, at least a scouring media can be directed to the first container by rinse mouth from the flushing source, and the isolation of fluid reservoir and fluid target each and the first fluid container.Scouring media can by the first rinse mouth be guided out the first container and be directed to the flushing receptor in, and fluid reservoir and fluid target each can isolate with the first fluid container.
Any suitable function or function combinations can be provided by the flushing of the first container.Can carry out the flushing of any number of times of the first container.In one embodiment, after the first container had been sterilized, clean water and/or air/noble gas can be used for washing the first container.The first container can be sterilized in any suitable manner, such as by wash with suitable sterilised medium the first container, by under the output that the first container is exposed to energy source (for example, heat, gamma radiation, ultraviolet light, infrared light and its any combination), or both of these case has.In the second situation, the first container can be sterilized, and its inner surface does not have the entity contact.
A fourth aspect of the present invention realizes by a kind of method for delivery of fluid.The first-class scale of construction guides to the first container from fluid reservoir.The first dosage is transported to the first fluid target, and wherein, the first dosage is at least a portion of the described first-class scale of construction.After the first dosage was removed or discharged from the first container, at least some any original first-class scale of constructions that are retained in the first container can be removed (for example, can carry out the trial of " emptying " the first container) from the first container.The second scale of construction can be directed to the first container from fluid reservoir.The second dosage is transported to the second fluid target, and wherein, the second dosage is at least a portion of the second scale of construction.Therefore, fourth aspect comprises fluid one after the other is delivered to a plurality of fluid targets.
Existence is about the various improvement of the feature of fourth aspect present invention.Further feature also can be incorporated in the above-mentioned fourth aspect of the present invention.These improvement and additional feature can be individually or are existed with the form of any combination.Until the following description before the fifth aspect present invention all belongs to this fourth aspect.The first-class scale of construction and the second scale of construction can be identical or different amounts.The first dosage and the second dosage can be identical or different amounts.The first dosage can be any part of the first-class scale of construction, comprises the whole of the first-class scale of construction.The second dosage can be any part of the second scale of construction, comprises the whole of the second scale of construction.
Any residue of the first-class scale of construction in the first container---it is that the first dosage is from being retained in the part in the first container after the first container is removed---can be removed in any suitable manner from the first container.This remaining at least some can take out and draw and get back to fluid reservoir from the first container.The first container can comprise can with the outlet of first fluid target fluid ground interconnection, and the first fluid target can disconnect with this outlet or fluid isolation at least, thus at least some residues can be discharged by this outlet and not advance to the first fluid target from the first container.The first container can comprise can with the outlet of first fluid target fluid ground interconnection, and can be used at least in part outlet of separating of emptying the first container (for example, the second outlet).Suitable fluid can be conducted through the first container, to remove any residue of the first-class scale of construction.Aforesaid any appropriate combination can be used for attempting the first container " emptying ".
The first-class scale of construction any remaining at least some removed from the first container or emptying after, the first container can be rinsed (for example, according to the third aspect) in any suitable manner.Any flushing of the first container can be to provide any suitable function or function combinations for the aforesaid mode of the third aspect.The first container also can be to sterilize (for example, wash the first container and/or it is exposed under the energy source output) for the aforesaid mode of the third aspect.
Scouring media can be conducted through the first container, and wherein, the first container keeps and first fluid target and each entity ground interconnection of fluid reservoir, and arrives fluid reservoir or first fluid target without any scouring media.Fluid reservoir and first fluid target each can with the isolation of this first fluid container, after this, scouring media can be introduced in the first container and from this first vessel empty.In the first embodiment, the outlet fluid isolation of the isolation of the inlet fluid of fluid reservoir and the first container and first fluid target and the first container, after this, scouring media is incorporated into the first container by entrance and exit respectively and discharges from the first container.In a second embodiment, the first inlet fluid isolation of fluid reservoir and the first container, the outlet fluid isolation of first fluid target and the first container, after this, scouring media is incorporated into the first container by the second entrance and exit respectively and discharges from the first container.In the 3rd embodiment, the inlet fluid isolation of fluid reservoir and the first container, the outlet fluid isolation of first fluid target and the first container, after this, scouring media is incorporated into the first container by the first and second rinse mouths respectively and discharges from the first container.In the 4th embodiment, the isolation of the inlet fluid of fluid reservoir and the first container, and the outlet fluid isolation of first fluid target and the first container, after this, scouring media is incorporated into the first container by shared rinse mouth respectively and discharges from the first container.
A fifth aspect of the present invention realizes by a kind of feature take flow control apparatus as characteristics.This flow control apparatus comprises housing and plunger.At least a portion of plunger is movably disposed within the housing.The first and second sealing members are installed on the described plunger and are spaced apart along described plunger, and engage the described inner surface of described housing.The first disinfecting substance is contained between described the first and second sealing members.
Existence is about the various improvement of the feature of fifth aspect present invention.Further feature also can be incorporated in the 5th above-mentioned aspect of the present invention.These improvement and additional feature can be individually or are existed with the form of any combination.Until the following description before the sixth aspect present invention all belongs to the 5th aspect.Flow control apparatus is included the fluid delivery system of fluid reservoir to be incorporated into.Fluid from this fluid reservoir can be incorporated in the flow control apparatus.Discharging or output from flow control apparatus can be directed into fluid target.In one embodiment, flow control apparatus and relevant " passing " type that flows from the stream of fluid reservoir.
The first and second sealing members can have any suitable size, shape, structure and/or type.In one embodiment, the first and second sealing members are forms of O shape ring.Between the first and second sealing members, can use any appropriate intervals.The first and second sealing members can move with respect to housing with plunger.Equally, the first disinfecting substance that is retained between the first and second sealing members can move with respect to housing with plunger.With the first disinfecting substance along the inner surface of housing move can " wipe and sweep " inner surface the bonding part with the contaminated solution problem.
The first disinfecting substance can engage the inner surface of housing.Term " inner surface of joint housing " etc. comprises any part of engages inner surface, and comprises the whole inner surface of joint.The first disinfecting substance can be any suitable type and/or form.The first disinfecting substance has sterilised liq, solid or is soaked with or comprises the form of other carrier of sterilised liq.Disinfecting substance can be merged in by sponge, cloth, porous material, water wetted material and its any combination or comprise.
Flow control apparatus can be the form of syringe.In this case, housing can be that the form of syringe cylindrical shell and at least a portion of plunger are arranged in the syringe cylindrical shell.Plunger can extend beyond the syringe cylindrical shell the end and can be by manual activation.Another program of syringe is to be applicable to power injector, and wherein, the driver of power injector can interconnect with plunger in any suitable manner, so that plunger is moved (for example providing from syringe cylindrical shell exhaust fluid) with respect to the syringe cylindrical shell.
Flow control apparatus can comprise that engaging with plunger is at least one biasing member.Any such biasing member can have any suitable size, shape, structure and/or type.Can use the biasing member of any right quantity.In one embodiment, plunger for the open position of flow control apparatus (for example is biased away from, " opening " position is the position that allows to flow through flow control apparatus), and (for example, " closing " position is the position that does not allow to flow through flow control apparatus) bias voltage towards the closed position.For example, plunger can be biased into a position, can not realize there the outflow from flow control apparatus.
The third and fourth sealing member can be installed on the described plunger and be spaced apart along described plunger.Described the third and fourth sealing member can engage the inner surface of described housing, and the second disinfecting substance can be contained between described the third and fourth sealing member.Can be applied to equally the second disinfecting substance about the first disinfecting substance in feature discussed above.Although the first and second disinfecting substances can be identical, this demand is also nonessential.The third and fourth sealing member can move with respect to housing along plunger.Equally, the second disinfecting substance that remains between the third and fourth sealing member also can move with respect to housing with plunger.Inner surface along housing moves the bonding part that inner surface could " be wiped and sweep " to the second disinfecting substance, solves pollution problem.
Described the first and second sealing members can limit the first sealing member pair, and described the third and fourth sealing member can limit the second sealing member pair.The first and second sealing members to can be along the plunger interval any suitable distance.In one embodiment, and when plunger is in when not having fluid from position that flow control apparatus flows out, the first sealing member is to can at least roughly being arranged as towards or being positioned at the entrance of flow control apparatus, and the second sealing member is to can at least roughly being arranged as towards or being positioned at the outlet of flow control apparatus.
Housing can comprise the first and second flow passages that are in the connection of selectivity fluid.In one embodiment, when described plunger was in primary importance (for example, the make position of flow control apparatus in this position, does not have fluid to flow out from flow control apparatus), the first and second flow passages are fluid isolation each other.In one embodiment, when described plunger is in the second position when (for example, in this position, there is fluid in the open position of flow control apparatus from the outflow of flow control apparatus), but the first and second flow passage fluid ground are communicated with.
The 5th sealing member can above-mentioned the first and second sealing members between be installed in a position on the plunger, and the 5th sealing member can engage with the inner surface of housing.At the 5th sealing member and first and second sealing member to making any appropriate intervals between each.
When described plunger was in primary importance (for example, the make position of flow control apparatus in this position, does not have fluid to flow out from flow control apparatus), described the 5th sealing member can be blocked in fluid connection between described the first and second flow passages.Described plunger is moved to the fluid that the second position can set up between the first and second flow passages be communicated with (for example, in this position, there is fluid in the open position of flow control apparatus from the outflow of flow control apparatus).That is, plunger is moved to the second position described the 5th sealing member is moved, thereby they are no longer between described the first and second flow passages, so that the fluid of setting up between described the first and second flow passages is communicated with.
Flow control apparatus can comprise with described housing removably or the medicated cap that removably engages.This medicated cap can be removed to allow the interconnection of flow control apparatus and another structural fluid ground, such as the adapter that can interconnect with fluid target fluid ground.This adapter can be a part etc. that extends to the pipeline group of fluid target (for example, patient) from flow control apparatus.
Above-mentioned adapter can removably or removably interconnect with housing in any suitable manner, such as being threadably engaged.Adapter can comprise the 3rd flow passage.Adapter and flow control apparatus interconnection can be interconnected above-mentioned first and second flow passages of flow control apparatus and the 3rd flow passage fluid ground of adapter.In one embodiment, adapter comprises the first member (for example, certain class second, static plunger) with any appropriate structuring.The 3rd flow passage can extend to from sidewall the interior section of the first member.The the 6th and the 7th sealing member can be installed in a position on the first member and be spaced apart along the first member, thus the 3rd flow passage between these the 6th and the 7th sealing members a position and the sidewall of the first member intersect.
Above-mentioned adapter can use any suitable covering or medicated cap (for example, stripping type band etc.).When adapter and flow control apparatus interconnection, this covering or medicated cap can be removed.The first member of adapter can be directed into the inside of flow control apparatus, thereby the above-mentioned the 6th and the 7th sealing member engages the inner surface of housing.Adapter is promoted the first member of adapter is engaged with plunger with respect to housing, thereby plunger moves to " open position " from " make position ", there, flowing through flow control apparatus advances, arrive in the adapter, then arrive fluid target (for example, via pipeline, adapter being installed on it).For example, adapter is installed to flow control apparatus can between above-mentioned first and second flow passages of flow control apparatus, sets up fluid and be communicated with, and also can between first and second flow passage of the 3rd flow passage of adapter and flow control apparatus, set up fluid and be communicated with.
A sixth aspect of the present invention is by a kind of method for delivery of fluid.Fluid can be provided for flow control apparatus, and wherein, described flow control apparatus comprises housing, and this housing has the inner surface that limits at least a portion conduit.Disinfectant member can move along at least a portion of described inner surface.Fluid can be from described flow control apparatus discharging.To flow through the part that is sterilized the element contact of conduit from least some fluids of flow control apparatus discharging.
Existence is for the various improvement of the described feature of sixth aspect present invention.Further feature also can be incorporated in the 6th above-mentioned aspect of the present invention.These improvement and additional feature can be individually or are existed with the form of any combination.Below description belongs to the 6th aspect, unless stated otherwise.Fluid can offer flow control apparatus in any suitable manner.In one embodiment, flow control apparatus has the form of syringe, and fluid can be loaded in the syringe in any suitable manner.In one embodiment, by with the interconnection of flow control apparatus and fluid reservoir fluid ground and fluid is offered flow control apparatus.This fluid reservoir can hold a plurality of fluid dosage, for example is used for a plurality of fluid targets.First fluid dosage can take out from fluid reservoir, is loaded into and/or the process flow control apparatus, from flow control apparatus discharging (for example, to the first fluid target).After flow control apparatus discharging, second fluid dosage can take out from fluid reservoir at first fluid dosage, is loaded into and/or through flow control apparatus, from flow control apparatus discharging (for example, to the second fluid target).No matter when should be understood that whole the first and second fluid dosage are not to be contained in flow control apparatus.
Disinfectant member can be installed on the plunger that is arranged in the conduit.Plunger can be mobile in conduit in any suitable manner, and it can make disinfectant member move along the inner surface of conduit thus.Disinfectant member is characterised in that can be at least roughly removable between the first and second positions, and wherein, flow control apparatus is characterised in that to have the flow path that extends through flow control apparatus and comprise at least above-mentioned conduit.When disinfectant member is in its primary importance, can be blocked through at least a portion of the flow path of flow control apparatus, when disinfectant member was in its second position, the flow path by flow control apparatus can be opened.In one embodiment, at least a portion of flow control apparatus is biased into the position that at least a portion of flow path is blocked.
The first fluid target can interconnect with flow control apparatus fluid ground.The movement of the first disinfectant member causes in response to the foundation of the fluid interconnection between first fluid target and the flow control apparatus or by it.After fluid was provided to the first fluid target by flow control apparatus, the first fluid target can disconnect from flow control apparatus.This disconnection can cause disinfectant member to move with respect to conduit.Disinfectant member is movable to and stops fluid from the relevant position of flow control apparatus output.After flow control apparatus disconnected, the second fluid target can interconnect with flow control apparatus fluid ground under any circumstance and in the first fluid target.Second fluid target and the interconnection of flow control apparatus fluid ground are moved disinfectant member again with respect to conduit.In case there is sufficient interconnection between second fluid target and the flow control apparatus, then fluid can leave flow control apparatus and by towards the second fluid goal directed.In one embodiment, being provided to each fluid of the first and second fluid targets from flow control apparatus is received by the common fluid reservoir.
The target side adapter can connect with flow control apparatus, and the target side adapter can interconnect with fluid target fluid ground.The open end of target side adapter can be with sealed before flow control apparatus engages.The open end of target side adapter can with sealing before the target side adapter engages.Each can be removed these sealing members, thereby target side adapter and flow control apparatus can connect.Target side adapter and flow control apparatus connected to cause disinfectant member with respect to moving with the related conduit of flow control apparatus.
There are the various improvement of above-mentioned feature about the present invention the first to the 6th aspect.Further feature also can be incorporated into the first to the 6th above-mentioned aspect of the present invention in each.For the first to the 6th aspect each, these improvement and additional feature can be individually or are existed with the form of any combination.That is, below describing each feature is not to use with any further feature or characteristics combination, unless stated otherwise.
Employed any fluid reservoir can have any suitable size, shape, structure and/or type.Also can use a plurality of fluid reservoirs.Any suitable fluid can be stored in any fluid reservoir that is used, and includes but not limited to contrast agent, radiopharmaceutical agent, saline and its any combination.In one embodiment, a plurality of fluid dosage can be stored in the fluid reservoir." dosage " can have the form of predetermined fluid amount, its be used to flow to a plurality of fluid targets each.Each dosage can be identical or different Fluid Volume.
Any fluid target can have any suitable size, shape, structure and/or type.An embodiment has the fluid target of patient's form.Another embodiment has the fluid target of animal form.Under any circumstance, fluid can flow to fluid target in any appropriate manner.For example, fluid can be injected into the particular fluid target.Fluid also can flow to the particular fluid target partly.
Syringe can be used for producing the fluid flow of fluid target, and this syringe can have any suitable size, shape, structure and/or type.Embodiment has the syringe (for example, can manually operated syringe) of form of the unit of manual activation.Another embodiment has the syringe (for example, can interconnect with unit head and can by the syringe that operation drove of this unit head) of power injector form.Also can use a plurality of syringes and with any suitable layout setting.
Any power injector can have any suitable size, shape, structure and/or type.Any such power injector can use the one or more syringe plunger drivers with any suitable size, shape, structure and/or type, wherein, each such syringe plunger driver can be carried out at least, and bidirectional-movement (for example, moves with exhaust fluid along first direction; Move to realize the loading of fluid along second direction, or in order to get back to position for subsequently fluid drainage operation).Power injector can be in any suitable manner (for example, enter into fluid target via injection, such as the patient) for any suitable application that needs one or more FLUID TRANSPORTATION, include but not limited to any suitable medical use (for example, computer tomography sciagraphy or CT imaging; Nuclear magnetic resonance or MRI; SPECT(single photonemission computed tomography: single photon emission computerized tomography) imaging; PET(Positron emission tomography: positron emission fault is taken a picture) imaging; The X-ray imaging; Angiographic imaging; Optical imagery; Ultra sonic imaging).The power injector use that can combine with any parts or unit construction is such as suitable imaging system (for example, CT scanner).For example, information (for example, delayed sweep information, injection initiating signal, injection flow) can be transmitted between power injector and one or more miscellaneous part.The syringe of any suitable quantity can be in any suitable manner (for example, removably; Front loading; Rear loading; Side is loaded) integrate with power injector, but the given syringe discharging of any suitable fluid driven force syringe, and any suitable fluid in any suitable manner (for example, one after the other, side by side) discharges from a plurality of syringe power injector structures, or any combination of above-mentioned situation.In one embodiment, the fluid of discharging from syringe by the operation of power injector is directed into conduit, locate the in any suitable manner fluid ground interconnection and fluid is directed to desired locations (for example, to the patient, for example being used for injection) of this conduit and syringe at this.
Description of drawings
Fig. 1 is the sketch map of an embodiment of power injector.
Fig. 2 A is the perspective view of being convenient to an embodiment of the mobile double end power injector that stand is installed.
Fig. 2 B is by amplification, the partial, exploded perspective view of the unit head of the power injector of Fig. 2 A use.
Fig. 2 C is by the sketch map of an embodiment of the syringe plunger driven unit of the power injector of Fig. 2 A use.
Fig. 3 A is the perspective view of an embodiment that utilizes the fluid delivery system of power injector.
Fig. 3 B is the perspective view of an embodiment of fluid delivery system that utilizes the syringe of manual activation.
Fig. 4 A is the sketch map of an embodiment that utilizes the fluid delivery system of at least one sterilising zone.
Fig. 4 B is the sketch map of another embodiment of fluid delivery system that utilizes a kind of layout of at least one sterilising zone and fluid reservoir and syringe.
Fig. 4 C is the sketch map of another embodiment of fluid delivery system that utilizes another layout of at least one sterilising zone and fluid reservoir and syringe.
Fig. 5 A is the sketch map of an embodiment of decontamination system, and this decontamination system utilizes intermediate cavity and can be incorporated in the fluid delivery system of Fig. 4 A-C.
Fig. 5 B is the sketch map of an embodiment of another decontamination system, and this decontamination system utilizes intermediate cavity and can be incorporated in the fluid delivery system of Fig. 4 A-C.
Fig. 5 C is the sketch map of an embodiment of another decontamination system, and this decontamination system utilizes intermediate cavity and can be incorporated in the fluid delivery system of Fig. 4 A-C.
Fig. 5 D is the sketch map of an embodiment of another decontamination system, and this decontamination system utilizes intermediate cavity and can be incorporated in the fluid delivery system of Fig. 4 A-C.
Fig. 6 is the sketch map of an embodiment of decontamination system, and this decontamination system utilizes energy source and can be incorporated in the fluid delivery system of Fig. 4 A-C.
Fig. 7 A is the sketch map of an embodiment of decontamination system, and this decontamination system utilization is from the disinfection manifold dynamic control device and can be incorporated in the fluid delivery system of Fig. 4 A-C.
Fig. 7 B is the sketch map of an embodiment of patient's side-connector of being combined with the decontamination system of Fig. 7 A.
Fig. 7 C has shown the decontamination system of Fig. 7 A, and it engages with patient's side-connector of Fig. 7 B.
Fig. 8 is the sketch map of another embodiment of decontamination system, and this decontamination system utilization is from the disinfection manifold dynamic control device and can be incorporated in the fluid delivery system of Fig. 4 A-C.
The specific embodiment
Fig. 1 shows the sketch map of an embodiment of the power injector 10 with unit head 12.One or more graphic user interfaces or GUI 11 can be related with unit head 12.Each GUI 11:1) can have any suitable size, shape, structure and/or type; 2) can functionally interconnect with unit head 12 in any suitable manner; 3) can be arranged in any suitable position; 4) can be configured to provide one or any combination in the following functions: one or more aspects of the operation of control power injector 10; One or more parameters of the operative association of input/editor and power injector 10; With show the suitable information operative association of power injector 10 (for example, with); Or 5) aforesaid any combination.Can use the GUI 11 of any right quantity.In one embodiment, power injector 10 comprises the GUI 11 that is incorporated into by control station, this control station separate with unit head 12 but with its communication.In another embodiment, power injector 10 comprises the GUI 11 as the part of unit head 12.In another embodiment, power injector 10 uses and a GUI 11 unit head 12 communications and on the control station that separates, also uses another GUI 11 on unit head 12.Each GUI 11 can provide identical function or one group of identical function, and perhaps GUI 11 can be different aspect relevant at least some of function separately with them.
Syringe 28 can be installed on this unit head 12, and to can be considered be the part of power injector 10.Some injection process can cause at the relatively high pressure of syringe 28 interior generations.In this case, syringe 28 need to be placed in the pressure jacket 26.Pressure jacket 26 is installed on the unit head 12 usually, afterwards syringe 28 is placed in the pressure jacket 26.On unit head 12, usually keep same pressure jacket 26 is installed, remove because various syringe 28 can be placed in the pressure jacket 26 and from pressure jacket, to be used for multiple injection process.If power injector 10 is configured/is utilized as for low head injection, power injector 10 working pressure sheath 26 not then.Under any circumstance, the fluid of discharging from syringe 28 can be directed into the conduit 38 of any appropriate size, shape, structure and/or type, this conduit can interconnect with syringe 28 fluid ground in any suitable manner, and this conduit is directed to any suitable position (for example, in patient body) with fluid.
Unit head 12 comprises syringe plunger driven unit 14, and itself and syringe 28 join that fluid is discharged from syringe 28.This syringe plunger driven unit 14 for example comprises drive source 16(, has the motor of any appropriate size, shape, structure and/or type, optional gear structure etc.), this drive source be driver output spare 18(for example, rotatable drive screw) power is provided.Push rod 20 can advance by (for example, axial) driven output 18 along suitable path.Push rod 20 can comprise coupling 22, is used for joining with the appropriate section of syringe 28 in the manner as described below.
Syringe 28 comprises plunger or piston 32, and it is movably disposed within the syringe cylindrical shell 30 and (for example, is used for along the axis axially reciprocating that overlaps with double-headed arrow B).Plunger 32 can comprise coupling 34.This syringe plunger coupling 34 can interconnect with push rod coupling 22, returns syringe plunger 32 to allow syringe plunger driven unit 14 in syringe cylindrical shell 30.Syringe plunger coupling 34 can be the form with head or button 36b and axle 36a, and this axle extends from the body of syringe plunger 32.But syringe plunger coupling 34 can have any suitable size, shape, structure and/or type.
Returning of syringe plunger 32 can be used for realizing that load fluids arrives in the syringe cylindrical shell 30, to be used for injection or discharging subsequently, in fact can be used for fluid is sucked in the syringe cylindrical shell 30.Being used for injection or discharging subsequently, or be used for any other suitable purpose.Some structures do not need syringe plunger driven unit 14 that syringe plunger 32 is return, and in this case, do not need push rod coupling 22 and syringe plunger coupling 34.Even when using push rod coupling 22 and syringe plunger coupling 34, it also can be so that advance syringe plunger 32 with from syringe 28 exhaust fluid (for example when push rod 20, push rod 20 is the near-end of " promotion " syringe plunger coupling 34 or syringe plunger 32 only) time, these parts can connect or can not connect.Can use along any suitable dimension or dimension combinations single and move or movement combination and push rod coupling 22 and syringe plunger coupling 34 are arranged as coupled situation or situation, or push rod coupling 22 and syringe plunger coupling 34 be arranged as break away from coupled situation or situation, or both of these case has.
Syringe 28 can be installed on the unit head 12 in any suitable manner.For example, syringe 28 can be configured to be directly installed on the unit head 12.In the embodiment shown, housing 24 suitably is installed on the unit head 12, with syringe 28 with provide during unit head is connected interface to connect.This housing 24 can be the form of adapter, and one or more syringe 28 structures can be mounted to this adapter, and in this case, at least one structure that is used for syringe 28 can be directly installed on unit head 12, and does not use any such adapter.This housing 24 can also be the form of floral disc (faceplate), and one or more syringe 28 structures can be mounted to this floral disc.In this case, can need to use floral disc that syringe 28 is installed on the unit head 12---this syringe 28 can not be installed on the unit head 12 in the situation of floral disc not having.When working pressure sheath 26, it can be being installed on the unit head 12 for syringe 28 described variety of ways in this article, and syringe 28 can be installed in the pressure jacket 26 subsequently.
When syringe 28 was installed, housing 24 can be mounted and remain in the position of fixing with respect to unit head 12.The another kind of selection is that housing 24 and unit head 12 are interconnected movably, realizes the installation of syringe 28.For example, housing 24 can move in the plane that comprises double-headed arrow A, so that coupled situation or in situation and disengaging coupled situation or the situation one or more between push rod coupling 22 and the syringe plunger coupling 34 to be provided.
A concrete power injector structure has been shown in Fig. 2 A, with Reference numeral 40 labellings, and has at least basically conformed to the power injector 10 of Fig. 1.Power injector 40 comprises the unit head 50 that is installed in the stand 48 of being convenient to move.The a pair of syringe 86a, the 86b that are used for power injector 40 are installed in unit head 50.In 40 operating periods of power injector, fluid can discharge from syringe 86a, 86b.
Be convenient to mobile stand 48 and can have any suitable size, shape, structure and/or type.Wheel, roller, swivel wheel etc. can be used for so that stand 48 is convenient to mobile.Unit head 50 can remain in the position of fixing with respect to the stand 48 of being convenient to move.But, expectation be, the position that allows unit head 50 at least some modes with respect to being convenient to mobile stand 48 capable of regulatings.For example, what expect is, when unit head 50 being in the position with respect to being convenient to mobile stand 48 when load fluids is in one or more syringe 86a, the 86b, also expectation is, in order to carry out injection process unit head 50 is placed in the different positions with respect to being convenient to mobile stand 48.In this case, unit head 50 can be in any suitable manner be convenient to mobile stand 48 interconnect movingly (for example, certain at least range of movement so that unit head 50 can pivot, and remaining in the desired locations subsequently).
Should be appreciated that unit head 50 can be supported in any suitable manner, be used for providing fluid.For example, replace being installed in and be convenient on the mobile structure, unit head 50 can interconnect with supporting component, and this supporting component is installed to again (for example, ceiling, wall, floor) on the appropriate configuration.Be used for any supporting component of unit head 50 adjustable position aspect at least some (for example, by one or more support sections are set, described support section can be reorientated with respect to one or more support sections), maybe can remain in the fixed position.In addition, unit head 50 can be integrated with any such supporting component, in order to remain on fixed position or can be with respect to the supporting component adjustment.
Unit head 50 comprises graphic user interface or GUI 52.This GUI 52 can be constructed to provide or any combination of following functions: one or more aspects of the operation of control power injector 40; One or more parameters that input/editor is relevant with the operation of power injector 40; The information (for example, operation with power injector 40 be associated) suitable with demonstration.Power injector 40 also can comprise control station 42 and power unit (powerpack) 46, control station and power unit each can both be in any appropriate manner (for example, via one or more cables) be communicated with unit head 50, and can be placed on the desktop in inspection chamber or any other appropriate location or be installed on the electronics rack, or both of these case has.Power unit 46 can comprise following one or more parts and its any appropriate combination: the power supply section that is used for syringe 40; Be used between control station 42 and unit head 50, providing the interface circuit of communication; Be used for allowing power injector 40 is connected to the circuit of remote unit, the all in this way remote consoles of this remote unit, long-range hands or Foot-controlled switch or other original equipment manufacturer (OEM) Long-distance Control connect (for example, exposing synchronously with the operation of permission power injector 40 and the x light of imaging system); With any other suitable parts.Control station 42 can comprise touch-screen display 44, and it can provide one or more and its any suitable combination of following functions thus: the one or more aspects that allow the operation of operator's Long-distance Control power injector 40; The one or more parameters that allow operator input/editor to be associated with the operation of power injector 40; Allow the operator to set and storage program, to be used for the automatic operation (this program is automatically performed by power syringe 40 subsequently) of power injector 40 when the person of being operated starts; Relevant with demonstration and power injector 40 and comprise that it operates any adequate information of any aspect.
Various details about syringe 86a, 86b and unit head 50 integration show in Fig. 2 B.Each syringe 86a, 86b comprise identical general parts.Syringe 86a comprises plunger or the piston 90a that is movably disposed within the syringe cylindrical shell 88a.Plunger 90a via the operation of unit head 50 along axis 100a(Fig. 2 A) motion will make fluid from the nozzle 89a discharging of syringe cylindrical shell 88a by syringe 86a.Suitable conduit (not shown) interconnects with nozzle 89a fluid ground usually in any suitable manner, with the position (for example, patient) that fluid is directed to expectation.Similarly, syringe 86b comprises plunger or the piston 90b that is movably disposed within the syringe cylindrical shell 88b.Plunger 90b via the operation of unit head 50 along axis 100b(Fig. 2 A) motion will make fluid from the nozzle 89b discharging of syringe cylindrical shell 88b by syringe 86b.Suitable conduit (not shown) interconnects with nozzle 89b fluid ground usually in any suitable manner, with the position (for example, patient) that fluid is directed to expectation.
Syringe 86a is via middle floral disc 102a and unit head 50 interconnection.This floral disc 102a comprises carriage 104, at least a portion of this bearing bracket syringe cylindrical shell 88a, and can provide/realize the combination of any additional function or function.Installed part 82a is arranged on the unit head 50 and with respect to it and fixes, and is used for joining with floral disc 102a.In the time of on being installed in unit head 50, the push rod coupling of push rod 74 76 is near floral disc 102a location, and each is a part for the syringe plunger driven unit 56 of syringe 86a for described push rod and push rod coupling.Detail about syringe plunger driven unit 56 will be done to discuss in further detail with reference to Fig. 2 C later.Usually, push rod coupling 76 can connect with the syringe plunger 90a of syringe 86a, and then push rod coupling 76 and push rod 74 can move with respect to unit head 50, so that syringe plunger 90a moves (Fig. 2 A) along axis 100a.This is so that when mobile syringe plunger 90a discharged with the nozzle 89a that fluid is passed through plunger 86a, push rod coupling 76 engaged with syringe plunger 90a, but really is not attached to this syringe plunger 90a.
Floral disc 102a can be at least basically mobile in a plane, this plane is associated with the motion of syringe plunger 90a, 90b respectively with axis 100a, 100b(, shown in Fig. 2 A) quadrature, remove floral disc 102a is installed on its installed part 82a on the unit head 50 and from this installed part.Floral disc 102a can be used for making syringe plunger 90a to connect with its corresponding push rod coupling 76 on unit head 50.In this respect, floral disc 102a comprises a pair of handle 106a.Usually, by at first syringe 86a being positioned in the floral disc 102a, handle 106a can be moved, with thus at least substantially being associated with the motion of syringe plunger 90a, 90b respectively with axis 100a, 100b(, shown in Fig. 2 A) movement/translation syringe 86a in the plane of quadrature.Handle 106a is moved to a position can be with syringe 86a(with respect to floral disc 102a) move/translation along downward direction at least substantially, connect with its corresponding push rod coupling 76 with the syringe plunger 90a with it.Handle 106a is moved to the another location can be with syringe 86a(with respect to floral disc 102a) move/translation along the direction that at least substantially makes progress, connect with its corresponding push rod coupling 76 disengagings with the syringe plunger 90a with it.
Syringe 86b is via middle floral disc 102b and unit head 50 interconnection.Installed part 82b is arranged on the unit head 50 and with respect to it and fixes, and is used for joining with floral disc 102b.In the time of on being installed in unit head 50, the push rod coupling 76 of push rod 74 is near floral disc 102b location, and each is the part of the syringe plunger driven unit 56 of syringe 86b for described push rod and push rod coupling.Detail about syringe plunger driven unit 56 also will be done to discuss in further detail with reference to Fig. 2 C subsequently.Usually, push rod coupling 76 can connect with the syringe plunger 90b of syringe 86b, and then push rod coupling 76 and push rod 74 can move with respect to unit head 50, so that syringe plunger 90b moves (Fig. 2 A) along axis 100b.This is so that when mobile syringe plunger 90a discharged with the nozzle 89b that fluid is passed through syringe 86b, push rod coupling 76 engaged with syringe plunger 90a, but really is not attached to this syringe plunger 90b.
Floral disc 102b can be at least basically mobile in a plane, this plane is associated with the motion of syringe plunger 90a, 90b respectively with axis 100a, 100b(, shown in Fig. 2 A) quadrature, remove floral disc 102b is installed on its installed part 82b on the unit head 50 and from this installed part.Floral disc 102b also can be used for making syringe plunger 90b to connect with its corresponding push rod coupling 76 on unit head 50.In this respect, floral disc 102b comprises a pair of handle 106b.Usually, by at first syringe 86b being positioned in the floral disc 102b, syringe 86b can be along its long axis 100b(Fig. 2 A) and rotate with respect to floral disc 102b.This rotation can realize by moving handle 106b, or by catching and rotate syringe 86b and realize, or realize by these two kinds operations.In any situation, this rotation is at least substantially being associated with the motion of syringe plunger 90a, 90b respectively with axis 100a, 100b(, shown in Fig. 2 A) the two moves/translation to make syringe 86b and floral disc 102b in the plane of quadrature.Along a direction rotation syringe 86b and floral disc 102b will be moved/translation along downward direction at least substantially syringe 86b, so that syringe plunger 90b is connected with its corresponding push rod coupling 76.Syringe 86b is rotated the direction that syringe 86b and floral disc 102b edge will be made progress at least substantially in opposite direction move/translation, connect with its corresponding push rod coupling 76 disengagings with the syringe plunger 90a with it.
Shown in Fig. 2 B, syringe plunger 90b comprises plunger body 92 and syringe plunger coupling 94.This syringe plunger coupling 94 comprises head 96 and axle 98, and this axle extends from plunger body 92, and this head and plunger body 92 intervals can.Each push rod coupling 76 comprises larger groove, and this larger groove is positioned at after the less groove on the face of push rod coupling 76.When the corresponding push rod coupling 76 of syringe plunger 90b and it is in coupled situation or situation, the head 96 of syringe plunger coupling 94 can be positioned in the larger groove of push rod coupling 76, and the axle 98 of syringe plunger coupling 94 is extensible by the less groove on the face of push rod coupling 76.Syringe plunger 90a can comprise similar syringe plunger coupling 94, is used for joining with its corresponding push rod coupling 76.
In the situation of power injector 40, unit head 50 is used for fluid is discharged from syringe 86a, 86b.That is, unit head 50 provides the motive power that fluid is discharged from each syringe 86a, 86b.An embodiment take the syringe plunger driven unit as characteristics is shown in Fig. 2 C, and it passes through Reference numeral 56 labellings, and can be utilized that fluid is discharged from each syringe 86a, 86b by unit head 50.Independent syringe plunger driven unit 56 can be incorporated in the unit head 50, is used for each syringe 86a, 86b.In this respect, and with reference to figure 2A-B, unit head 50 can comprise manual operation knob 80a and 80b, is used for controlling dividually each syringe plunger driven unit 56.
At first, and with reference to the syringe plunger driven unit 56 of Fig. 2 C, each can have any suitable size, shape, structure and/or type its all parts.Syringe plunger driven unit 56 comprises motor 58, and this motor has output shaft 60.Driven wheel 62 is installed on the output shaft 60 of motor 58 and thereupon rotation.Driven wheel 62 engages with driven gear 64 or can engage with this driven gear at least.This driven gear 64 is installed on drive screw or the axle 66 and thereupon rotation.Drive screw 66 rotation around the Reference numeral of axis be 68.One or more bearings 72 suitably support drive screw 66.
Balladeur train (carriage) or push rod 74 are installed on the drive screw 66 movably.Usually, drive screw 66 along the rotation of a direction with push rod 74 along the direction of corresponding syringe 86a/b along drive screw 66(thus along axis 68) axially advance, and drive screw 66 rotation in opposite direction with push rod 74 along drive screw 66(thus along axis 68) axially advance away from corresponding syringe 86a/b.In this respect, the periphery of at least a portion of drive screw 66 comprises screw 70, and at least a portion of this screw thread and push rod 74 is joined.Push rod 74 also is installed in the suitable lining 78 movably, and this lining does not allow push rod 74 to rotate in the rotary course of drive screw 66.Therefore, the rotation of drive screw 66 provides the axially-movable of the direction that push rod 74 determines along the direction of rotation by drive screw 66.
Push rod 74 comprises coupling 76, and this coupling can removably connect with the syringe plunger coupling 94 of the syringe plunger 90a/b of corresponding syringe 86a/b.When push rod coupling 76 and syringe coupling plunger 94 suitably connected, syringe plunger 90a/b moved with push rod 74.Fig. 2 C shows a structure, and wherein syringe 86a/b can move along its respective axis 100a/b and not be attached to push rod 74.When syringe 86a/b moves along its respective axis 100a/b, thereby the head 96 of its syringe plunger 90a/b is aimed at push rod coupling 76, but axis 68 still is in bias voltage when structure shown in Fig. 2 C, and syringe 86a/b can move translation in the plane of axis 68 quadratures on institute edge with push rod 74.This has set up the joint of the connection between push rod coupling 76 and the syringe plunger coupling 96 in the above described manner.
The power injector 10 of Fig. 1 and 2 A-C, 40 each can be used for any suitable application, include but not limited to that imaging of medical uses, wherein, fluid is injected to main body (for example, patient).For power injector 10,40, representational imaging of medical is used and is included but not limited to computer tomography sciagraphy or CT imaging, nuclear magnetic resonance or MRI, SPECT imaging, PET imaging, X-ray imaging, angiographic imaging, optical imagery and ultra sonic imaging.Power injector 10,40 each can use separately or be used in combination with one or more miscellaneous parts.Power injector 10,40 each can with the interconnection of one or more operation of components ground, thereby for example information can power injector 10,40 and one or more miscellaneous part between transmit (for example, delayed sweep information, injection initiating signal, injection flow).
Each power injector 10,40 can use any amount of syringe, includes but not limited to single head structure (being used for single syringe) and dual head configuration (being used for two syringes).In the situation of a plurality of needle cylinder structures, each power injector 10,40 can be in any suitable manner and according to order any time (for example, one after the other discharge from two or more syringes, discharge simultaneously from two or more syringes, or its any combination) fluid is discharged from each syringe.Can be comprised any suitable fluid, for example contrast agent, radiopharmaceutical agent or saline by each power injector 10,40 each such syringe that uses.Can be installed in any suitable manner and (for example, can use rear mounting structure by each power injector 10,40 each such syringe that uses; Can use front mounting structure).
Many application include but not limited to various medical and veterinary's processes, all need the FLUID TRANSPORTATION of one or more dosage to main body or patient, or more generally are transported to fluid target.Fig. 3 A has represented the perspective view of the embodiment of fluid delivery system 300A, and it can be used in such application, during perhaps any other suitably used.Fluid reservoir 302 can interconnect with fluid target 318 and the two fluid ground of syringe 306a, and in this case, syringe 306a has the form of power injector.Fluid reservoir 302 can comprise any suitable fluid, comprises the combination (for example, contrast agent, radiopharmaceutical agent, saline and its any combination) of a kind of fluid or different fluid.Fluid target 318 can have any suitable type (for example, patient, animal).Fluid target 318 can receive fluid from fluid reservoir 302 in any suitable manner, includes but not limited to inject in any suitable manner.Power injector 306a can have any suitable size, shape, structure and/or type (for example, at least roughly with 40 described conforming to of power injector of above power injector 10 for Fig. 1 and Fig. 2 A), and comprises unit head 310.Therefore, although unit head 310 has illustrated single syringe 312, syringe 306a can be dual head configuration (for example, conforming to the power injector 40 of Fig. 2 A).
Fluid delivery system 300A comprises the parts that are commonly referred to " pipeline group (tubing set) " etc., and it is with Reference numeral 307 labellings.Pipeline group 307 and fluid reservoir 302, power injector 306a and the interconnection of fluid target 318 fluid ground.Pipeline group 307 comprises feature and the feature take single use portion 308 as characteristics take reusable part 309 as characteristics.Pipeline group 307 can have any suitable size, shape, structure and/or type, can use any suitable conduit or the catheter combination that arrange with any appropriate configuration, or can incorporate in any appropriate manner one or more parts into and described parts provide any suitable function or function combinations, or any combination of above-mentioned situation.
One or more directed flow control device 304 can be incorporated in any appropriate position of pipeline group 307.For example, one or more directed flow control device 304 can be used at the loading days of syringe 312 or during fluid is expelled to fluid target 318 subsequently or during the both of these case control fluid flow.Each can have any suitable size, shape, structure and/or type the directed flow control device 304 that is used by fluid delivery system 300A.In one embodiment, directed flow control device 304 can have the form of check valve, this check valve be oriented as reduce during injecting fluid reflux in the fluid reservoir 302 probability or the probability that refluxes from fluid target 318 at syringe 312 loading dayses.
Fig. 3 B is the perspective view of another embodiment of fluid delivery system 300B, and this system has a plurality of identical above-mentioned parts, but has the syringe 306b of the syringe form of manual activation.In these and other embodiment, fluid is from fluid reservoir 302 taking-ups and then be provided to fluid target 318 via pipeline group 307.Although fluid injector 302 shown in Fig. 3 A-B for being separating component, in other embodiments, its can have pre-filled syringe form or can be otherwise and syringe (for example, the syringe 306a of any suitable type; Syringe 306b) integrates.Fluid reservoir 302 can comprise standardized Fluid Volume, and it can be more than the required total amount of given fluid target 318.
Also comprised single use portion 308 and reusable part 309 by the pipeline group 307 of the fluid delivery system 300A of Fig. 3 A and 3B and each use of 300B respectively.Common one or more sterilising zone can be distributed on the pipeline group 307, thereby all upstream components of the reusable part 309 of pipeline group 307 and corresponding fluids induction system 300A, 300B can be used to fluid for example is provided to a plurality of fluid target 318(, based on continuous benchmark).This then allows fluid reservoir 302 to hold a plurality of fluid dosage.Explain the various fluid delivery systems of incorporating at least one such sterilising zone into below with reference to Fig. 4 A-C.Explain each embodiment of the decontamination system that in these sterilising zones, uses below with reference to Fig. 5 A-D and 6-8.Do not incorporate one or more sterilising zones in fluid delivery system 300A, the 300B of Fig. 3 A-B, many fluid delivery system parts can change based on each fluid target 318 and abandon usually.For example, this can comprise the syringe 312 of whole pipeline group 307, fluid reservoir 302, Fig. 3 A and the syringe of Fig. 3 B/syringe 306b, and may be exposed to other fluid path parts from the pollutant of fluid target 318.When fluid reservoir 302 is abandoned and is changed, when being used for fluid target 318 subsequently, any fluid that remains in wherein is wasted usually.In at least some cases, abandoned fluid can be very expensive product (for example, contrast agent).
Fig. 4 has shown the sketch map of the embodiment of fluid delivery system 400A, and this fluid delivery system has by the fluid source 314 of pipeline group 307 with at least one sterilising zone 316 and the interconnection of fluid target 318 fluid ground.Fluid source 314 can have any suitable size, shape, structure and/or type.In various embodiments, fluid source 314 can comprise fluid reservoir, is combined separately or with conveyer device, and wherein, conveyer device comprises syringe or can be guided through other mechanism of at least one sterilising zone 316 before fluid is arrived fluid target 318.Fluid reservoir can be the parts that separate with conveyer device, and such as fluid reservoir 302 and syringe 306a, the 30b of Fig. 3 A-B, or fluid reservoir and conveyer device can be merged into individual unit.Any fluid reservoir that separates and conveyer device can be with any suitable layout settings with respect to sterilising zone 316 and/or fluid target 318.In various embodiments, fluid delivery system 400A can comprise a plurality of fluid sources 314, sterilising zone 316 and/or fluid target 318.
Can use any amount of sterilising zone 316.In any situation, pipeline group 307 has single use portion 308 and reusable part 309, this single use portion for example is disposed generally on fluid target 318 and at least one sterilising zone 316(, nearest sterilising zone 316) between, this reusable part for example is disposed generally on fluid source 314 and at least one sterilising zone 316(, nearest sterilising zone 316) between.Each sterilising zone 316 comprises at least one decontamination system, reduces pollutant from the probability of fluid target 318 by pipeline group 307 backflows and arrival fluid source 314, reduces waste by making fluid source 314 be recycled and reused for a plurality of fluid targets 318 thus.
Fig. 4 B shows another embodiment of fluid delivery system 400B, and it has by two fluid sources 314 of pipeline group 307 with one or more sterilising zones 316 and the interconnection of fluid target 318 fluid ground.Pipeline group 307 comprises single use portion 308 and reusable part 309, this single use portion for example extends at least one sterilising zone 316(from fluid target 318 at least, nearest sterilising zone 316), reusable part for example extends at least one sterilising zone 316(from one of them fluid source 314 at least, nearest sterilising zone 316).In one embodiment, two fluid sources 314 can comprise respectively fluid reservoir 302 and syringe 306, and wherein, syringe 306 has the form of syringe or any other suitable conveyer device of aforesaid power injector, manual activation.Fluid passes through the single sterilising zone 316 of at least one sterilising zone 316(among described embodiment from fluid reservoir 302) to arrive syringe 306.Syringe 306 is guided through fluid the single sterilising zone 316 of at least one sterilising zone 316(in described embodiment subsequently) to arrive fluid target 318.Fluid delivery system 400B can use the sterilising zone 316 of any right quantity, comprises only using one of them sterilising zone 316.In any situation, each sterilising zone 316 comprises at least one decontamination system, with reduce pollutant reflux by pipeline group 307 and arrive fluid source 314(from fluid target 318 comprise fluid reservoir 302) probability, reduce waste by making fluid reservoir 302 be recycled and reused for a plurality of fluid targets 318 thus.In the embodiment that uses the sterilising zone 316 between syringe 306 and fluid target 318, also can protect the parts of syringe 306 not to be subjected to the pollution of the pollutant that shed from fluid target 318.
Fig. 4 C shows another embodiment of fluid delivery system 400C, it has by the fluid target 318 of pipeline group 307 with a plurality of fluid sources 314 and the interconnection of one or more sterilising zone 316 fluid ground, and wherein each sterilising zone 316 comprises aforesaid at least one decontamination system.Pipeline group 307 also comprises single use portion 308, and this single use portion extends at least one sterilising zone 316 from fluid target 318 at least.This pipeline group 307 also comprises one or more reusable parts 309, and this each reusable part extends to the sterilising zone 316 that is arranged between fluid source 314 and the fluid target 318 at least from one of them fluid source 314, if any.As the fluid delivery system 400B of Fig. 4 B, fluid source 314 can comprise respectively fluid reservoir 302 and syringe 306.In the phase I, fluid flow to syringe 306 from fluid reservoir 302, alternatively by one or more sterilising zones 316.In next stage, fluid can flow to fluid target 318 from syringe 306, alternatively by one or more sterilising zones 316.Although illustrated embodiment uses three sterilising zones 316, fluid delivery system 400C can be suitable for comprising the sterilising zone (for example, only use in the sterilising zone 316 one or two) of any right quantity.Depend on which sterilising zone 316 is comprised among the fluid delivery system 400C, can protect in the fluid source 314 one or two not to be subjected to the pollution of the pollutant that shed from fluid target 318.
Fig. 5 A-D shows can be by each embodiment of the decontamination system of the fluid delivery system 300A-B of above-mentioned Fig. 3 A-B and 4A-C and 400A-C or any other proper flow body conveying system use.At first with reference to figure 5, intermediate cavity decontamination system 500A comprises rinse-system 520 and container 502a.Rinse-system 520 comprise flushing source 508 and flushing receptor 510 the two, they each interconnect with container 502a fluid ground via the first entrance 504 and the first outlet 506 respectively.Oxirane), fluids for sterilization, water, air, noble gas, noble gas combination, bleach, hydrogen peroxide, oxygen, any suitable desiccant and its any combination flushing source 508 can hold any suitable scouring media, includes but not limited to ethanol, steam, ETO(ethylene oxide:.The combination of a kind of scouring media or two or more different scouring medias can be used in flushing source 508, and described scouring media can be by fluid source 508 in any suitable manner with any suitable sequentially-fed.Each scouring media can provide any suitable function or function combinations.A plurality of scouring medias can be guided through container 502a based on any suitable benchmark.
Flushing source 508 can have any suitable structure provides function described herein.Flushing receptor 510 can have any suitable structure, such as the form with storage vessel or waste material discharge device etc.The first entrance 504 of container 502a and/or the first outlet 506 and any other mouthful can be set to work passively, for example use one-way valve system.Alternatively, they can use manually operated parts, such as pushing open mouthful or twisting mouth (push or twist ports), or use electromagnetic valve actuation device or some other automatic systems.Mouth 504,506 and any other vessel port of container 502a do not need to incorporate into any mobile control function.Alternatively, the control function that flows can provide by incorporating valve control in any conduit etc. into.Intermediate cavity decontamination system 500A also can use one or more flow conditioners, to help container 502a and flushing source 508, flushing receptor 510, fluid source 314 and/or the interconnection of fluid target 318 fluid ground and to disconnect/isolation.Each such flow conditioner can have any suitable size, shape, structure and/or type, and can be designed to passively, automatically, manually, come work based on one or more signals or with any combination of these methods.
During the mobile delivery phase in the decontamination system 500A situation, the first entrance 504 is via fluid source flow conditioner 512a and the interconnection of fluid source 314 fluid ground, and the first outlet 506 is via fluid target flow conditioner 512b and the interconnection of fluid target 318 fluid ground.Flushing source flow actuator 512c and flushing receptor flow conditioner 512d remain on make position, thereby container 502a and flushing source 508 and flushing receptor 510 fluid ground disconnect or isolation.The first-class scale of construction can be directed to container 502a from fluid source 314 thus, and after this, at least a portion of the first-class scale of construction can be directed to fluid target 318 from container 502a.
After the fluid of desired amount has been transported to fluid target 318, can stop in any suitable manner (for example, by fluid target flow conditioner 512b) to the flow of fluid target 318.In addition, reverse by making flow direction, the fluid volume among the container 502a can reduce, or container 502a can be emptying and without any residual fluid, thereby at least some residual fluids turn back to fluid source 314.In the embodiment of this technology of use, be necessary to prevent that fluid from refluxing from fluid target 318, this for example can realize container 502a and the disconnection of fluid target 318 fluid ground or isolation by closing the first outlet 506 and/or fluid target flow conditioner 512b.In addition or alternatively, by closing fluid target flow conditioner 512b or otherwise making container 502a and the disconnection of fluid target 318 fluid ground or isolation, open flushing receptor flow conditioner 512d, then by the first outlet 506 any residual fluid is escaped and enter flushing receptor 510, can container 502a is emptying.On the other hand, one or more flow conditioners can be constructed to make container 502a and fluid source 314 and fluid target 318 fluid ground to disconnect or isolation, and make container 502a and flushing source 508 and be connected receptor 510 fluid ground and be connected.Subsequently, by scouring media is directed to the container 502a from flushing source 508 by the first outlet 504, leave container 502a by the first outlet 506, and enter flushing receptor 510, thereby subsequently container 502a is washed.
Another embodiment of intermediate cavity decontamination system 500B is shown in Fig. 5 B, and comprises that container 502b, this container have all features of the container 502a of Fig. 5 A, also have the second entrance 514.The rinse-system 520 that comprises flushing source 508 and flushing receptor 510 iBut be connected with container 502b fluid ground, still different from the layout that represents in Fig. 5 A (and thus, subscript " i " is used for sign rinse-system 520 i).Flushing source 508 and the interconnection of the second entrance 514 fluid ground, this can eliminate with one or more flow conditioners needs that optionally interconnect in the first entrance 504 and fluid source 314 and the flushing source 508.When fluid is transported to fluid target 318, the first entrance and exit 504,506 and fluid target flow conditioner 512b open, and the second entrance 514 and flushing receptor flow conditioner 512d keep closing.Then container 502b can disconnect or isolation with fluid target 318 fluid ground by closing the first outlet 506 and/or fluid target flow conditioner 512b, after this, at least some of residual fluid among the container 502b can be drained and get back to fluid source 314, as mentioned above.Additional or alternatively, after opening the first outlet 506 and flushing receptor flow conditioner 512d and after closing fluid target flow conditioner 512b, container 502b can be emptied to and wash in the receptor 510.Again be directed to flushing receptor 510 in case leave flowing of container 502b via the first outlet 506 from flow target 318, and do not consider whether at least some residual fluids among the container 502b are removed or with which kind of method remove that then the first entrance 504 can be closed and the second entrance 514 can be opened.At least roughly by the described mode of above-mentioned embodiment for Fig. 5 A, by at least a scouring media is directed to the container 502b from flushing source 508 by the second entrance 514, leave container 502b by the first outlet 506, and enter into flushing receptor 510, container 502b can be sterilized subsequently.
In another embodiment, intermediate cavity decontamination system 500C comprises container 502c, and all features that it has the container 502b of Fig. 5 B also have the outlet of second shown in Fig. 5 C 516.The rinse-system 520 that comprises flushing source 508 and flushing receptor 510 IiCan be connected with container 502c fluid ground, (and thus, subscript " ii " is used for sign rinse-system 520 but they are different from the layout that represents in Fig. 5 A-B Ii).This structure allow container 502c and fluid source 314 and fluid target 318 or with flushing source 508 and wash receptor 510 optionally fluid be communicated with, and do not need the flows outside actuator.After fluid had been transported to fluid target 318, container 502c can disconnect or isolation with fluid target 318 fluid ground in any suitable manner.Can for example at first close as described above the second entrance 514(, rinse mouth) and the first and second outlets 506,516(for example, the second outlet 516 can be described as rinse mouth) and open the first entrance 504 and in the residual fluid among the container 502c at least some removed and directly are directed in the fluid source 314.Additional or alternatively, at first close the first entrance and exit 504,506 and open the second outlet 516 after, at least some of the residual fluid among the container 502c are bootable in the flushing receptor.At least roughly by the described mode of above-mentioned embodiment for Fig. 5 A, by further opening the second entrance 514, then at least a scouring media is directed to the container 502c from flushing source 508 by the second entrance 514, leave container 502c and enter flushing receptor 510 by the second outlet 516, container 502c can be rinsed subsequently.
Fig. 5 D shows another embodiment of intermediate cavity decontamination system 500D, it comprises container 502d, this container has the first entrance 504, the first outlet 506 and rinse mouth 5185, wherein rinse mouth 518 and flushing source 508 and wash receptor 510 optionally fluid be communicated with.The rinse-system 520 that comprises flushing source 508 and flushing receptor 510 IiiCan be connected with container 502d fluid ground, still different from the layout that represents in Fig. 5 A-C (and thus, subscript " iii " is used for sign rinse-system 520 Iii).After fluid had been transported to fluid target 318, container 502d can disconnect or isolation with fluid target 318 fluid ground.By closing rinse mouth 518 and the first outlet 506, then at least some residual fluids are led back in the fluid source 314 by the first entrance 504, at least some in the residual fluid among the container 502d can be removed subsequently.Additional or alternatively, closing the first entrance and exit 504,506, close flushing source flow actuator 512c and open after the flushing receptor flow conditioner 512d, at least some of the residual fluid among the container 502d can be directed in the flushing receptor 510 by rinse mouth 518.Eluant container 502d can relate to: at least a scouring media is directed to container 502d from flushing source 508 by rinse mouth 518, then by same rinse mouth 518 this scouring media is discharged and removed from container 502d, and this scouring media is directed in the flushing receptor 510.During this process, flow conditioner 512c, 512d alternately open and close, and are communicated with suitably to set up fluid between rinse mouth 518 and flushing source 508 or flushing receptor 510.Alternatively, flow conditioner 512c, 512d are unidirectional in essence, thereby each flow conditioner 512c, 512d allow fluid only to flow along a direction, shown in the arrow of Fig. 5 D.
Each mouthful that is used for the container 502a-d of Fig. 5 A-D can comprise or can not comprise the control function (for example, valve control) that flows.Disconnect or isolation can realize in any suitable manner for the fluid of the described various parts of embodiment of Fig. 5 A-D, as can as described in set up fluid between the parts and be communicated with.The flushing of each container 502a-d can utilize the combination of two or more scouring medias or unite to come the repetition one or many.At least one flushing operation can be associated vessel 502a-d sterilizing function is provided.For example, disinfecting container 502a-d can include but not limited to, at first uses ethanol eluant container 502a-d, and water eluant container 502a-d then is at last with noble gas or other desiccant eluant container 502a-d.
One or more intermediate cavity decontamination system 500A-D can be arranged in above-mentioned fluid delivery system 400A-C sterilising zone 316 any one or a plurality of.Thus, disconnect or isolation from the fluid of fluid source 314 and fluid target 318 although aforementioned discussion relates to the fluid interconnection of container 502a-d and fluid source 314 and fluid target 318 and container 502a-d, should be appreciated that those connections can be indirectly.For example, when middle chamber decontamination system 500A-D was used for sterilising zone 316 between two fluid sources 314 at the fluid delivery system 400B of Fig. 4 B, it can be connected directly to syringe 306 and only indirectly be connected to fluid target 318.
Fig. 6 shows can be by each embodiment of the decontamination system 600 of the fluid delivery system 300A-B of above-mentioned Fig. 3 A-B and 4A-C and 400A-C or any other proper flow body conveying system use.Decontamination system 600 comprises energy source 602 and flow path 604, and at least a portion that wherein has the flow path 604 of length L is exposed under the output of energy source 602.Energy source 602 can include but not limited to, thermal source, radiation source or other radiation property energy source, in the situation of given certain degree of exposure, it can reduce the fluid contamination degree in the flow path 604, for example by neutralizing and/or eliminating antibacterial or other pollutant that are present in the fluid that passes flow path 604, (for example, heat, gamma irradiation, ultra-vioket radiation, infrared light and its any combination).Reduce pollution level and can comprise and fluid being exposed under uniform temperature or the radiation dose and through specific open-assembly time, wherein, the particular exposed time at least long enough to guarantee with acceptable definitiveness pollutant being reduced to tolerance level.Pollutant also can have maximum propagation speed, and it can be with this speed by diffuse fluid or otherwise spread near material.Then the minima that is used for length L can multiply by by the maximum propagation speed with pollutant the particular exposed time and calculate.Can prevent that entering pollutant the expose portion of flow path 604 from the direction of fluid target 318 propagates along the direction of fluid source 314 and surpass this expose portion.Decontamination system 600 can be used in one or more sterilising zones 316, thereby the fluid that flows between fluid source 314 and fluid target 318 passes flow path 604, and can be exposed to thus under the output of energy source 602.In this way, can prevent that the pollutant that enter fluid delivery system 400A-C from fluid target 318 from infiltrating fluid source 314.
Fig. 7 A-C shows can be by the sketch map (for example, cutaway view) of another embodiment of the decontamination system of the fluid delivery system 300A-B of above-mentioned Fig. 3 A-B and 4A-C and 400A-C or any other proper flow body conveying system use.Flow control apparatus 700 from sterilization comprises the plunger 702 that is movably disposed within the housing 704, and this housing has inner surface 705.This inner surface 705 can limit conduit or the flow path for fluid flow, or this inner surface can with flow control apparatus 700 in fluid join, or both of these case has.The first and second sealing members 706,708 are installed on the plunger 702, and spaced apart along this plunger, and engage with the inner surface 705 of housing 704.The first disinfecting substance 710 is contained between the first and second sealing members 706,708, thereby attempts to run into the first disinfecting substance 710 by the first and second sealing members 706, any pollutant of 708.In addition, the third and fourth sealing member 712,714 is installed on the plunger 702, and to separate along plunger 702 apart from the first and second sealing members 706,708 certain distance.The second disinfecting substance 716 can be arranged between the third and fourth sealing member 712,714.The first and second disinfecting substances 710,716 also engage the inner surface 705 of housing 704, thereby can be along the inswept disinfecting substance 710 of at least a portion of inner surface 705,716, to process the pollutant on it at housing 704 interior mobile plungers 702.Each disinfecting substance 710,716 can include but not limited to, sterilised liq, sterilization colloid, sterilizing gas and its any combination perhaps infiltrate sponge, cloth, porous material, water wetted material and its any combination that any suitable medium with suitable disinfecting properties is arranged.
Flow control apparatus 700 from sterilization also has the first and second flow passages 718,720, and wherein flow passage 718 can interconnect with fluid source 314 fluid ground.The 5th sealing member 728 by the first and second sealing members 706,708 sealing members that limit to and by the third and fourth sealing member 712,714 sealing members that limit between be installed on the plunger 702, and be positioned as so that when plunger 702 is in the closed position, stop that the fluid between the first and second flow paths 718,720 is communicated with, shown in Fig. 7 A.Thus, when the flow control apparatus 700 of sterilization was in its closed position certainly, the fluid 722 that enters the first flow passage 718 only can flow to the 5th sealing member 728.Also comprise biasing member 726 from disinfection manifold dynamic control device 700, described biasing member is bonded between the end wall 724 of plunger 702 and housing 704, wherein, biasing member 726 with plunger 702 towards the closed position of Fig. 7 A bias voltage.Although biasing member 726 shown in Fig. 7 A for being spring, but should be appreciated that, can use any appropriate ways (for example, utilizing the one or more biased elements with any suitable size, shape, structure and/or type) that plunger 702 is biased into the closed position of Fig. 7 from disinfection manifold dynamic control device 700.
Fig. 7 A also comprises medicated cap 730 from disinfection manifold dynamic control device 700.Medicated cap 730 is removably attached to the end of housing 704.In one embodiment, medicated cap 730 is screwed on the screw 732 that is positioned on housing 704 ends.But, should be appreciated that medicated cap 730 can removably join with housing 704 in any suitable manner.
Fig. 7 B is for the sketch map (for example, cutaway view) with the fluid target side-connector 740 that uses from disinfection manifold dynamic control device 700 of Fig. 7 A.Connector shell 742 holds the first member 746, at this first member the 6th and the 7th sealing member 748,750 is installed.The 3rd flow passage 752 intersects with the sidewall 747 of the first member 746 between the 6th and the 7th sealing member 748,750 and extends through the first member 746, thereby the 3rd flow passage 752 can interconnect with fluid target 318 fluid ground.Protectiveness covering 744 removably is attached to the end of connector shell 742, and wherein, protectiveness covering 744 can be embodied as stripping type covering or any other suitable cladding system.Can use any mode that protectiveness covering 744 removably is attached to connector shell 742.Target side adapter 740 also can have the screw 754 on the inwall 756 that is positioned at connector shell 742, being threaded with screw 732 on the end of housing 704.But, can use fluid target side-connector 740 is attached to any appropriate ways from disinfection manifold dynamic control device 700.
After protectiveness covering 744 is removed (Fig. 7 B) from connector shell 742; and at medicated cap 730 after remove (Fig. 7 A) from the housing 704 of disinfection manifold dynamic control device 700; fluid target side-connector 740 can with from disinfection manifold dynamic control device 700 interconnection, shown in Fig. 7 C.Before fluid is transported to fluid target 318, with fluid target side-connector 740 with connect the first member 746 that causes fluid target side-connector 740 from disinfection manifold dynamic control device 700 and engage from the plunger 702 of disinfection manifold dynamic control device 700 and with it and push away the make position of Fig. 7 A, thus along the inswept disinfecting substance 710 of the some parts of inner surface 705,716, to process any pollutant on it.In case fluid target side-connector 740 with fully engage from disinfection manifold dynamic control device 700, then plunger 702 is arranged in its open position of Fig. 7 C, is communicated with thereby the 5th sealing member 728 no longer stops the fluid between first and second flow passages 718,720 of disinfection manifold dynamic control device 700.In addition, the 3rd flow passage 752 second flow passages 720 existing and from disinfection manifold dynamic control device 700 of fluid target side-connector 740 align, thereby first, second, and third flow passage 718,720,752 forms continuous-flow path 758.The the 6th and the 7th sealing member 748 of fluid target side-connector 740,750 inner surfacies 705 that engage from the housing 704 of disinfection manifold dynamic control device 700 are to be directed to fluid the 3rd flow passage 752 of fluid target side-connector 740.In this way, the fluid 722 that enters from disinfection manifold dynamic control device 700 from fluid source 314 can flow through continuous-flow path 758 towards fluid target 318.
In case the fluid of desired amount has been transported to fluid target 318 or after this, fluid target side-connector 740 can be from disconnecting from disinfection manifold dynamic control device 700.Target side adapter 740 is removed permission biasing member 726 plunger 702 is moved back into the make position shown in Fig. 7 A.This motion of plunger 702 is thus so that disinfecting substance 710,716 is again inswept along the some parts of the inner surface 705 of housing 704, and any pollutant on the inner surface 705 are stayed in processing transporting fluid into fluid target 318 after thus.
Fig. 8 is from the sketch map of another embodiment of disinfection manifold dynamic control device 800 (cut away view), and it at least roughly uses at least a portion from the disinfection principle of disinfection manifold dynamic control device 700 of Fig. 7 A-C.Corresponding component between the embodiment of Fig. 7 A-C and Fig. 8 is indicated with same reference numerals.Also further indicate by " single quotation marks " labelling at those different aspect at least some corresponding components.Comprise the plunger 702 ' that is movably disposed within the housing 704 ' from disinfection manifold dynamic control device 800, this housing has inner surface 705 '.The first and second sealing members 706,708 are installed on the plunger 702 ', and spaced apart along this plunger, and engage with the inner surface 705 ' of housing 704 '.Disinfecting substance 710 is contained between the first and second sealing members 706,708, thereby attempts to run into disinfecting substance 710 by the first and second sealing members 706, any pollutant of 708.Disinfecting substance 710 also engages the inner surface 705 ' of housing 704 ', thereby mobile plunger 702 ' can be along the inswept disinfecting substance 710 of at least a portion of inner surface 705 ', to process the pollutant on it in housing 704 '.
In the embodiment shown, substantially be constructed to syringe from disinfection manifold dynamic control device 800, wherein, housing 704 ' forms the cylindrical shell of syringe and also comprises nozzle 760.Plunger 702 ' the extensible end that surpasses housing 704 ', and can include but not limited to handle 762, this handle is used for manually advancing plunger 702 '.Alternatively, plunger 702 ' can comprise any structure that plunger 702 ' is attached to power injector, such as by comprising the syringe plunger coupling 94 of Fig. 2 B-C.Loading can comprise from disinfection manifold dynamic control device 800 returns plunger 702, drag or otherwise allow fluid to flow in the housing 704 ' by nozzle 760 with suction, and discharging comprises from disinfection manifold dynamic control device 800 and advances plunger 702 so that fluid is discharged by nozzle 760.Thus, by advance plunger 702 ' carry out per injection before and/or afterwards, at least a portion of the inner surface 705 ' of housing 704 ' experience is disinfected.
The decontamination system 500A-D, 600 of Fig. 5 A-8,700 and 800 each with and any combination can be incorporated into respectively fluid delivery system 300A-B and the 400A-C of Fig. 3 A-B and 4A-C, or any other proper flow body conveying system, to reduce the potential contamination from fluid target 318 to one or more fluid sources 314.In addition, the element of above-mentioned decontamination system is capable of being combined to produce other embodiment; For example, the energy source 602 of Fig. 6 can be configured to join with any container 502a-d of the intermediate cavity decontamination system 500A-D of Fig. 5 A-D, as the additional or replacement method that reduces the pollutant in the container 502a-d.Under any circumstance, pollutant penetrate into the less risk of fluid source 314, and fluid is offered fluid target 318, thereby fluid source 314 can be reused the fluid target 318 for subsequently.Orientate other fluid conveying part (such as the reusable part 309 of conduit set 307) relative with sterilising zone 316 as with respect to fluid target 318 and also can be adequately protected and the not impact of contaminated thing, in order to be recycled and reused for subsequently fluid target 318.The some of them of many advantages that obtain thus can comprise the packing cost that reduces, the safer conveying of quick processing speed, the fluid wastage that reduces and high value or high purity substance when less parts is changed between fluid target 318 in succession.
Carried out foregoing description of the present invention for explaination and illustration purpose.In addition, this description is not intended restriction and limits the invention to form disclosed here.Thereby variant and the modification of fitting mutually with technology and the knowledge of above-mentioned instruction and association area all fall within the scope of the present invention.The embodiment that more than discloses also is intended to explain enforcement known optimised form of the present invention, and so that use (one or more) or use (one or more) according to the present invention, those skilled in the art utilizes the present invention and each variant in such or other embodiment.The claims intention is interpreted as comprising the alternative embodiment of prior art institute tolerance level.

Claims (11)

1. fluid delivery system comprises:
Fluid reservoir;
The first flow path extends to fluid target from described fluid reservoir;
Syringe is with the described first mobile path flow body ground interconnection; With
Energy source, wherein, at least a portion of described the first flow path is exposed under the output of described energy source.
2. fluid delivery system as claimed in claim 1, wherein, described fluid reservoir comprises contrast agent.
3. such as each the described fluid delivery system among the claim 1-2, wherein, described fluid reservoir comprises a certain amount of fluid, is used for realizing a plurality of fluid delivery process.
4. such as each the described fluid delivery system among the claim 1-3, wherein, described the first flow path comprises at least one conduit.
5. such as each the described fluid delivery system among the claim 1-4, wherein, described the first flow path comprises removably the first and second duct portions of interconnection, wherein, described the first duct portion extends to fluid target and for disposable from described the second duct portion, and wherein, described the second duct portion can be reused to be used for a plurality of fluid delivery process.
6. fluid delivery system as claimed in claim 5, wherein, at least a portion of described the first duct portion is exposed to the described output of described energy source.
7. such as each the described fluid delivery system among the claim 1-6, wherein, described syringe comprises power injector.
8. such as each the described fluid delivery system among the claim 1-6, wherein, described syringe comprises the syringe of manual activation.
9. such as each the described fluid delivery system among the claim 1-8, wherein, described energy source comprises at least one heater.
10. such as each the described fluid delivery system among the claim 1-8, wherein, described energy source comprises radiation source.
11. such as each the described fluid delivery system among the claim 1-10, wherein, described the first flow path has about at least 13 centimetres of described outputs that are exposed to from described energy source.
CN201210442417.4A 2007-11-19 2008-11-19 Fluid delivery system with multi-dose fluid source Expired - Fee Related CN102989055B (en)

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Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2506889T (en) * 2009-12-03 2018-08-01 Jean Pierre Peters Fluid interconnection set with particle filter
KR20130097633A (en) * 2010-04-16 2013-09-03 고조 인더스트리즈, 인크 Taggant keying system for dispensing systems
US9295742B2 (en) 2012-04-16 2016-03-29 Puracath Medical, Inc. System and method for disinfecting a catheter system
FR2991881B1 (en) * 2012-06-13 2014-09-05 Medex Sa DEVICE FOR INJECTING A LIQUID PRODUCT COMPRISING TWO MOBILE HALF-SHELLS IN ROTATION IN RELATION TO EACH OTHER
KR102177981B1 (en) * 2012-12-05 2020-11-13 브라코 이미징 에스.피.에이. Validation techniques for fluid delivery systems
WO2014120620A1 (en) 2013-01-29 2014-08-07 Puracath Medical, Inc. Apparatus and method for disinfecting a catheter
US9408981B2 (en) 2013-03-10 2016-08-09 Bayer Healthcare Llc Adjustable volume syringe
US9855385B2 (en) 2013-03-13 2018-01-02 Bayer Healthcare Llc Multiple compartment syringe
US9114215B2 (en) 2013-03-13 2015-08-25 Bayer Medical Care Inc. Multiple compartment syringe
US10322227B2 (en) 2013-03-15 2019-06-18 410 Medical, Inc. Apparatus, kits and related methods for fluid infusion
US10688294B2 (en) 2013-06-14 2020-06-23 Bayer Healthcare Llc Portable fluid delivery system
CN103656800A (en) * 2013-12-19 2014-03-26 周佩龙 Needle cylinder with ultraviolet sterilization function
CN116474198A (en) * 2014-01-10 2023-07-25 拜耳医药保健有限公司 Method for automatically priming a single-use disposable set connector by a fluid injector system
CN103831223B (en) * 2014-03-06 2015-07-08 迈得医疗工业设备股份有限公司 Coating method and coating device for additives on inner wall of blood collection tube
US11007361B2 (en) 2014-06-05 2021-05-18 Puracath Medical, Inc. Transfer catheter for ultraviolet disinfection
NO2689315T3 (en) 2014-10-28 2018-04-14
US9199033B1 (en) 2014-10-28 2015-12-01 Bayer Healthcare Llc Self-orienting syringe and syringe interface
BR112017008878B1 (en) 2014-10-28 2022-10-11 Bayer Healthcare Llc PRESSURE SHIRT
US11129934B2 (en) 2014-10-28 2021-09-28 Bayer Healthcare Llc Self-orienting pressure jacket and pressure jacket-to-injector interface
KR102528289B1 (en) 2015-01-09 2023-05-03 바이엘 헬쓰케어 엘엘씨 Multiple fluid delivery systems with multiple use disposable sets and features thereof
EP3261694B1 (en) 2015-02-24 2021-03-24 410 Medical, Inc. Apparatus and kits for fluid infusion
CA2983120C (en) 2015-03-18 2023-09-12 Puracath Medical, Inc. Catheter connection system for ultraviolet light disinfection
EP3277397A1 (en) * 2015-03-31 2018-02-07 GE Healthcare Bio-Sciences AB A liquid chromatograhy system, a device, and a method
EP3804782B1 (en) * 2015-08-28 2023-07-26 Crisi Medical Systems, Inc. Flow sensor system with connection assembly
KR101687199B1 (en) * 2015-10-13 2016-12-19 주식회사 우영메디칼 Medical Fluid Supply Valve for Medical Fluid Infuser
CN108472433B (en) 2015-11-13 2021-12-14 拜耳医药保健有限公司 Nested syringe assembly
EP3423130A1 (en) 2016-03-03 2019-01-09 Bayer Healthcare LLC System and method for improved fluid delivery in multi-fluid injector systems
CA3027532A1 (en) 2016-06-15 2017-12-21 Bayer Healthcare Llc Multi-use disposable system and syringe therefor
US10239088B2 (en) * 2017-03-22 2019-03-26 Ford Motor Company Fluid application system adapted to collect and reuse reclaimed fluid
CN110891630B (en) 2017-08-31 2022-04-26 拜耳医药保健有限公司 System and method for drive member positioning and fluid injector system mechanical calibration
EP3676854A1 (en) 2017-08-31 2020-07-08 Bayer Healthcare LLC Fluid path impedance assessment for improving fluid delivery performance
CN110869071B (en) * 2017-08-31 2023-05-02 拜耳医药保健有限公司 Method of dynamic pressure control in a fluid injector system
WO2019046267A1 (en) 2017-08-31 2019-03-07 Bayer Healthcare Llc Fluid injector system volume compensation system and method
US11793898B2 (en) * 2017-09-27 2023-10-24 Merck Patent Gmbh Sanitation assembly and method
US11191893B2 (en) 2018-01-31 2021-12-07 Bayer Healthcare Llc System and method for syringe engagement with injector
CN112236218B (en) * 2018-04-02 2022-04-26 滴管公司 System and method for continuous flow emulsion processing
CA3110859A1 (en) * 2018-08-28 2020-03-05 Bayer Healthcare Llc Fluid injector system, method of preventing fluid backflow, and computer program product
CN115485783A (en) 2020-04-30 2022-12-16 拜耳医药保健有限责任公司 Systems, devices, and methods for protecting the health of a patient for fluid injection
CA3210215A1 (en) 2021-03-08 2022-09-15 Andrew W. Lane Systems, apparatus, and methods for fluid infusion

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2063018U (en) * 1989-12-14 1990-10-03 乌鲁木齐市友谊医院 Tube-type machine for treating blood
WO2002064195A2 (en) * 2001-02-14 2002-08-22 Acist Medical Systems, Inc. Catheter fluid control system
EP1107804B1 (en) * 1998-08-28 2002-09-25 Schering Aktiengesellschaft Syringes and injectors incorporating magnetic fluid agitation devices
US20030135250A1 (en) * 2002-01-17 2003-07-17 Brian Lauman Medical fluid heater using radiant energy
CN1582175A (en) * 2001-11-05 2005-02-16 斯冈株式会社 Flow passage selector device, and contrast medium filling tube used for the device
US20070142774A1 (en) * 1999-08-05 2007-06-21 Biocardia, Inc. System and Method for Delivering Thermally Sensitive and Reverse-Thermal Gelation Materials
US7267666B1 (en) * 1995-04-20 2007-09-11 Acist Medical Systems, Inc. Angiographic injector system with multiple processor redundancy
CN101068588A (en) * 2003-12-24 2007-11-07 玛琳克特公司 Fluid infusion apparatus with an insulated patient line tubing for preventing heat loss

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1961023A (en) * 1933-12-07 1934-05-29 Herman O West Plunger for hypodermic syringes
GB1212565A (en) * 1968-05-29 1970-11-18 West Pharmarubber Ltd Hypodermic syringe
US4416663A (en) * 1981-10-26 1983-11-22 Steri-Pac, Inc. Self-sterilizing hypodermic syringe
SE453361B (en) * 1985-06-04 1988-02-01 Gambro Ab SYSTEM FOR MANAGING A MEDICAL TREATMENT, INCLUDING DIALYSIS
US5037395A (en) * 1989-06-02 1991-08-06 Denco, Inc. Catheter for suppressing tunnel infection
DE9010361U1 (en) 1989-07-08 1991-02-07 Hirsch, Gesine, 8000 Muenchen, De
US5116652A (en) * 1989-10-13 1992-05-26 Abbott Laboratories Kink-resistant medical tubing and catheters
US5356375A (en) * 1992-04-06 1994-10-18 Namic U.S.A. Corporation Positive pressure fluid delivery and waste removal system
JPH05329209A (en) 1992-06-03 1993-12-14 Japan Steel Works Ltd:The Positron drug injector and method for operating injector
US5328463A (en) * 1992-09-18 1994-07-12 Namic U.S.A. Corporation Contrast media and fluid introduction system
US5342320A (en) * 1993-01-15 1994-08-30 Cameron Robert W Hypodermic syringe having shielding to prevent accidental injury following use
US5423751A (en) * 1993-02-18 1995-06-13 Harrison; Samuel W. Contrast media dispensing apparatus
US5353691A (en) * 1993-04-14 1994-10-11 Habley Medical Technology Corp. Self-lubricating piston for pharmaceutical container
ATA164293A (en) * 1993-08-17 1995-09-15 Dieringer Franz A COUPLING FOR CONNECTING HOSE PIPES
EP0650739B1 (en) * 1993-10-28 2003-02-26 Medrad, Inc. Total system for contrast delivery
US5569181A (en) * 1993-10-28 1996-10-29 Medrad, Inc. Sterility assurance for contrast delivery system
JP3323628B2 (en) * 1994-02-02 2002-09-09 浜松ホトニクス株式会社 Radiopharmaceutical injection device
US5586975A (en) * 1994-02-18 1996-12-24 Takeda Chemical Industries. Ltd. Air and liquid tight container with a slidable gasket
DK0821566T3 (en) * 1995-04-20 2004-01-26 Acist Medical Sys Inc Angiographic injector
US6099502A (en) * 1995-04-20 2000-08-08 Acist Medical Systems, Inc. Dual port syringe
US5569208A (en) * 1995-08-01 1996-10-29 Merit Medical Systems, Inc. System for managing delivery of contrast media
US6187400B1 (en) * 1996-05-03 2001-02-13 Baxter International Inc. Medical tubing and pump performance enhancement by ionizing radiation during sterilization
US6142977A (en) * 1996-10-18 2000-11-07 Schering Ag Prefilled, sterilized syringe with a new and improved plug
JP3878699B2 (en) * 1996-10-21 2007-02-07 日東工器株式会社 Pipe fitting
US5921759A (en) * 1997-10-14 1999-07-13 Sandeep Khan Liquid metering piston pump and valves capable of being cleaned and sterilized without disassembly
JP4270748B2 (en) * 1997-11-07 2009-06-03 アシスト・メディカル・システムズ・インコーポレーテッド Angiographic syringe apparatus with multiple processor redundancy
US6872197B1 (en) * 1997-11-14 2005-03-29 Schering Ag Tank for administering flowable substances
US6355024B1 (en) * 1999-07-14 2002-03-12 Mallinckrodt Inc. Medical fluid delivery system
JP4293689B2 (en) * 1999-10-05 2009-07-08 株式会社根本杏林堂 Contrast medium injection device
US6596230B1 (en) * 2000-01-28 2003-07-22 Baxter International Inc. Device and method for pathogen inactivation of therapeutic fluids with sterilizing radiation
US6626862B1 (en) * 2000-04-04 2003-09-30 Acist Medical Systems, Inc. Fluid management and component detection system
US6471674B1 (en) * 2000-04-21 2002-10-29 Medrad, Inc. Fluid delivery systems, injector systems and methods of fluid delivery
JP2002345952A (en) * 2001-05-30 2002-12-03 Shimizu Pharmaceutical Co Ltd Tube connector for artificial dialysis
US6767319B2 (en) * 2001-06-29 2004-07-27 Medrad, Inc. Delivery methods, systems and components for use with hazardous pharmaceutical substances
US7611503B2 (en) * 2004-04-16 2009-11-03 Medrad, Inc. Fluid delivery system, fluid path set, sterile connector and improved drip chamber and pressure isolation mechanism
US6800072B2 (en) * 2002-06-26 2004-10-05 Medex, Inc. Contrast dispensing system
JP4515037B2 (en) * 2003-03-27 2010-07-28 株式会社根本杏林堂 Chemical solution injection method and chemical solution injection device
WO2004091688A2 (en) * 2003-04-08 2004-10-28 Medrad, Inc. Fluid delivery systems, devices and methods for delivery of hazardous fluids
EP1642606A1 (en) * 2003-07-07 2006-04-05 Nemoto Kyorindo Co., Ltd. Chemical liquid injection system detecting attachment and detachment of chemical liquid syringe to and from chemical liquid injection device
CN100536943C (en) * 2003-07-18 2009-09-09 株式会社根本杏林堂 Medicine infuser for displaying image of entered infusion condition
US7621892B2 (en) * 2003-12-31 2009-11-24 Mallinckrodt Inc. Contrast container holder and method to fill syringes
WO2005084732A1 (en) * 2004-03-03 2005-09-15 Nemoto Kyorindo Co., Ltd. Medical solution injection system
JP2007532234A (en) * 2004-04-12 2007-11-15 メドラッド インコーポレーテッド Fluid transfer system, pressure isolation mechanism, injector control mechanism, and method using the same
GB2414405B (en) * 2004-05-28 2009-01-14 Cilag Ag Int Injection device
US7891974B2 (en) * 2004-07-07 2011-02-22 The Board Of Regents Of The University Of Texas System Portable fluid warming system
ATE481584T1 (en) * 2004-07-30 2010-10-15 Gl Tool And Mfg Co Inc VALVE
US7445604B2 (en) * 2004-10-04 2008-11-04 Biosensors International Usa Blood sampling kit and method of using same
US20060079842A1 (en) * 2004-10-13 2006-04-13 Liebel-Flarsheim Company Powerhead control in a power injection system
JP4604764B2 (en) * 2005-02-25 2011-01-05 東レ株式会社 Luer lock type fluid connector plug and medical device
EP1726328A1 (en) * 2005-05-26 2006-11-29 Jean-Pierre Peters Contrast fluid delivery system
JP2009506879A (en) * 2005-09-07 2009-02-19 コヴィディエン・アクチェンゲゼルシャフト Syringe structure
EP1779883A1 (en) * 2005-10-27 2007-05-02 Hotwatch ApS Portable device for heating intravenous fluids
GB0607401D0 (en) * 2006-04-12 2006-05-24 Glaxosmithkline Biolog Sa Novel device

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2063018U (en) * 1989-12-14 1990-10-03 乌鲁木齐市友谊医院 Tube-type machine for treating blood
US7267666B1 (en) * 1995-04-20 2007-09-11 Acist Medical Systems, Inc. Angiographic injector system with multiple processor redundancy
EP1107804B1 (en) * 1998-08-28 2002-09-25 Schering Aktiengesellschaft Syringes and injectors incorporating magnetic fluid agitation devices
US20070142774A1 (en) * 1999-08-05 2007-06-21 Biocardia, Inc. System and Method for Delivering Thermally Sensitive and Reverse-Thermal Gelation Materials
WO2002064195A2 (en) * 2001-02-14 2002-08-22 Acist Medical Systems, Inc. Catheter fluid control system
CN1582175A (en) * 2001-11-05 2005-02-16 斯冈株式会社 Flow passage selector device, and contrast medium filling tube used for the device
US20030135250A1 (en) * 2002-01-17 2003-07-17 Brian Lauman Medical fluid heater using radiant energy
CN101068588A (en) * 2003-12-24 2007-11-07 玛琳克特公司 Fluid infusion apparatus with an insulated patient line tubing for preventing heat loss

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CN102989055B (en) 2015-03-04
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CN101868266B (en) 2015-01-07
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CN102989056B (en) 2015-06-17
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US8747356B2 (en) 2014-06-10
JP2013176702A (en) 2013-09-09
EP2283883A3 (en) 2011-10-12
EP2222358B1 (en) 2013-01-02
JP2012016618A (en) 2012-01-26
JP5787714B2 (en) 2015-09-30
US20100249586A1 (en) 2010-09-30
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CN102989056A (en) 2013-03-27
JP2012016619A (en) 2012-01-26
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CN101868266A (en) 2010-10-20
ES2401942T3 (en) 2013-04-25

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