A kind of H-bridge circuit defibrillator output stage and two-phase sawtooth square wave defibrillation high-voltage discharge method
Technical field
The invention belongs to medical electronics technical field, be specifically related to a kind of output-stage circuit for cardiac defibrillator, and based on the high-voltage discharge method of this output-stage circuit.
Background technology
Cardiac sudden death (SCD) is the unexpected type circulation collapse that occurs immediately occurring in 1 hour in clinical symptoms and to asystole, is the major causes of death of cardiovascular disease.The epidemiological study result display at U.S.'s health statistics center be SCD more than 50% in all cardiovascular deaths, and the SCD of annual China is total more than 54.4 ten thousand examples; In the past few decades, along with the generation of aged tendency of population process SCD is on the rise simultaneously.Wherein, the SCD of 80% owing to malignant ventricular arrhythmia, as ventricular fibrillation (VF, be called for short room quiver).Owing to quivering etc. in room, normal without omen, during outbreak, the electrical activity of ventricle loses synchronicity in malignant ventricular arrhythmia outbreak, and cardiac pumping function is lost, and turns a multiple rhythm of the heart as taken measures not in time, will cause dying suddenly within several minutes.And quiver in this room wherein more than 90%, the morbidity place of patient is outside hospital, often cannot obtain treatment in time.So within the time short as far as possible, the room of termination is quivered, recovers normal cardiac rhythm, is recovered hemodynamic stability, is the top priority avoided and effectively prevent SCD from occurring.At present, uniquely a kind of method that effectively can stop myocardium fibrillation is electric defibrillation (ED is called for short defibrillation) clinically, namely carries out High Voltage electric shock to heart, makes myocardial cell repolarization, get back to respective affective state, restart normally to beat.The appearance of automated external defibrillator (AED) makes early stage defibrillation outside hospital become possibility, and the intelligent characteristic of its " identification automatically, automatic analysis, automatically defibrillation " becomes simple by electric defibrillation operation, the amateur common people also can take on the spot and implement defibrillation rescue to SCD patient in time, shorten rescue time, improve the rescue survival rate of SCD.
The electric current that defibrillator discharges should be can the room of the termination minimum energy of quivering, and the threshold current of the electric defibrillation of general adult is 10 ~ 25 amperes, and energy is 50 ~ 300 joules.Energy is excessive or electric current is too high not only can cause myocardial damage and skin burn, and can be larger to organic heart damages such as ischemic hearts.The electric energy that defibrillator exports is finally be discharged into it patient by certain discharge waveform.Therefore, in order to reduce myocardial damage and the excessive side effect of defibrillation, Chinese scholars has carried out large quantifier elimination to defibrillation charging method and waveform, and some discharge waveforms once and used comprise: single-phase damping sinusoidal wave, single-phase index chopped wave, two phase exponential chopped wave, burst pulse array two phase exponential chopped wave etc.Experimentation confirms, potential gradient meansigma methods during defibrillation with biphasic wave needed for cardiac muscle is only 1/2 of single-phase ripple, and required defibrillation energy is also significantly reduced to 200 joules by 360 joules during single-phase DC defibrillation accordingly.As can be seen here, during the equal defibrillation energy of equal applying, the success rate of bi-phase wave is far above single-phase ripple.At present, medical circle not yet has generally acknowledged conclusion for the electrophysiological mechanism of defibrillation technology, defibrillator on market or AED mostly are the biphasic defibrillation ripple of exponential damping type, make every effort to, while ensureing the higher synchronous defibrillation success rate of myocardial cell, realize the damage minimum to heart with minimum discharge energy as far as possible.
The thorax impedance of general human body is at 20 ~ 150 ohms, there is larger individual variation, existing defibrillator, usually according to the thorax impedance size measured, changes discharge inception voltage amplitude or the discharge current waveform width of biphasic defibrillation ripple, reaches discharge energy Automatic adjusument and control.Defibrillation charging method described in Chinese patent 200510120801.2A " Waveform generating method of defibrillation bi-phase wave ", its waveform parameter comprises fixing pulse period and adjustable discharge inception voltage.Chinese patent 200580047116.A " has at the automated external defibrillator (AED) forming the discrete sensing pulse used in treatment biphasic waveform ", this sensing pulse is used for determining the special parameters such as the thorax impedance of patient before release defibrillation waveform, and based on this parameter adjustment discharge waveform.Chinese patent 200710046179.4A " realizes method and the device of low energy defibrillation " by burst pulse be when the discharge waveform of defibrillation is two phase exponential truncation exponential wave, and each pulsewidth clicked is adjustable between 0.5ms ~ 4ms.Chinese patent 200910061191.1 " Intelligent intermediate-frequency bi-directional square wave defibrillation method " the intermediate frequency constant current of 5KHz detects thorax impedance, and corresponding adjustment discharge waveform parameter, patient is sent to the biphasic defibrillation plexi pulse square wave of 5KHz intermediate frequency.US Patent No. 6,671,546 and patent US6,493, the multiple-pulse bi-phase wave technology of a kind of similar higher frequency disclosed in 580, fixed the cycle of first-phase defibrillation pulse and second-phase defibrillation pulse, and biphasic waveform is divided into multiple narrow pulse waveform and forms.Although above patent and all have employed biphasic defibrillation ripple, positive and anti-phase essence only have a ripple, and exponentially decay decline form.Its main deficiency is: the peak position national highway of (1) exponential wave exceedes Defibrillator threshold, not only wastes energy but also easily produced strong stimulation to cardiac muscle generation damage; (2) energy hole deviation is comparatively large, and the energy of defibrillator release adjusts according to thorax impedance, and the more difficult individuation that realizes accurately controls, the patient that particularly impedance is high especially or low especially; (3) peak position of exponential wave, requires the capacitor energy of higher starting voltage and the defibrillation output stage of Geng Gao requirement of withstand voltage.
Summary of the invention
The object of the invention is to for above-mentioned the deficiencies in the prior art and propose a kind of H bridge discharge circuit defibrillator output stage for cardiac defibrillator, and using the cardiac defibrillator of this H bridge road defibrillator output stage; The two-phase sawtooth square wave high-voltage discharge method with boost function based on this H-bridge circuit defibrillator output stage is proposed simultaneously, so that for different patients, the defibrillation electric energy that individuation more accurately controls is provided, obtain the electric discharge output voltage higher than energy-storage capacitor source voltage simultaneously, reduce and the high pressure characteristics on electric discharge bridge road is required and saving components cost.
The two-phase sawtooth square wave high-voltage discharge method for defibrillation that the present invention proposes, namely by comprising the defibrillator output stage on a H bridge road, with a series of bridge way switch combination preset and control strategy, electric energy in accumulator is with it carried out once rapidly high-voltage electric shock electric discharge with the impulse form of two-phase sawtooth waveforms patient via defibrillation electrode, with this cessative aspect ventricular Fibrillation, implement to rescue in time patient; The high pressure defibrillation electric discharge of above-mentioned two-phase sawtooth square waveform, provide a form and present the thin ripple of sawtooth to being in Fibrillated ventricular muscles and be superimposed upon defibrillation discharge current on two-phase square wave, for the defibrillation electric energy that patient provides individuation accurately to control, be conducive to the success rate improving the ventricle synchronous defibrillation of myocardial cell everywhere, and effectively reduce in high pressure defibrillation procedure the damage that cardiac muscle is formed.
Specifically being constructed as follows of the defibrillator output-stage circuit that the defibrillation charging method that the present invention proposes is used:
Described defibrillator output stage, is made up of at least one energy-storage capacitor, inductance coil, semiconductor diode, a current sensor and four gauge taps; Wherein, four gauge taps form H bridge type discharge circuit (comprise positive pulse branch road and rp pulse branch road, or high-pressure side branch road and low-pressure side branch road), export the defibrillation current flow of diphasic pulse via defibrillation electrode to patient;
Described defibrillator output stage, at least comprises an inductance coil, this inductance coil and patient's H bridge in series road transverse arm;
Described defibrillator output stage, at least comprise a semiconductor diode, this diode is in parallel with bridge way switch, has afterflow effect when switch disconnects;
Described defibrillator output stage, at least comprises positive (or anti-phase) the continuous current discharge electricity bridge road be made up of above-mentioned inductance coil and above-mentioned fly-wheel diode;
Described defibrillator output stage, at least comprises a current sensor, and this current sensor is placed in a certain bridge road branch road, senses the current amplitude of this branch road in discharge process in real time;
Utilize the cardiac defibrillator that above-mentioned H bridge road defibrillation output stage is formed, as shown in Figure 4.Use the cardiac defibrillator of defibrillator output stage of the present invention, wherein, except defibrillator output stage, comprise: main control module, battery module, thorax impedance and electrocardiogram acquisition analysis module, human-computer interaction module and wireless communication module, in addition high-voltage charging module is also had, time-sequence control mode, comparator, D/A transducer.High-voltage charging module provides high-tension electricity for device output stage of quivering; Thorax impedance and electrocardiogram acquisition analysis module, human-computer interaction module and wireless communication module, time-sequence control mode, D/A transducer, be connected with main control module, respectively by master control module controls; Defibrillator output stage is connected with main control module, forms H-bridge circuit switch, all by master control module controls in defibrillator output stage by gauge tap is interconnected.Above-mentioned each functional module is all connected with battery module, provides power supply by it.
In the present invention, described cardiac defibrillator, has patient's electrocardio, thorax impedance physiological parameter measurement function.
In the present invention, described cardiac defibrillator, can according to patient age, the body weight of input, or the thorax impedance size detected, the waveform parameters such as the reference interval value of self-adaptative adjustment defibrillation discharge current amplitude, positive sawtooth waveforms sum and anti-phase sawtooth waveforms sum.
In the present invention, described cardiac defibrillator, the measurement of discharge current is realized by ohmage; Measure the current value obtained to be realized by comparator with comparing of reference value, wherein reference value is exported by microcontroller to determine.
In the present invention, described cardiac defibrillator, its control to H bridge road low-pressure side branch road two switches, adjustment waveform parameter are realized by microcontroller (MCU).
In the present invention, described cardiac defibrillator, it is realized by PLD (CPLD) to the control of H Qiao Lu high-pressure side branch road two switches.
In the present invention, described cardiac defibrillator, the current value that current sensor measurement obtains was realized by comparator with comparing of reference value, and wherein reference value is exported by microcontroller to determine.
In the present invention, described cardiac defibrillator, described H bridge way switch comprises one or more IGBT or SCR switch.
The present invention, according to the thorax impedance of the shocked by electricity abnormal electrocardiogram information detected and patient, automatically presets defibrillation discharge waveform parameter, and exports two-phase sawtooth square wave high-voltage electric shock electric current to patient immediately.Current sensor in H bridge road detects the amplitude of discharge current in electric defibrillation process in real time, and compare with the current amplitude reference interval value preset, and then pass through positive phase discharge bridge road (or anti-phase electric discharge bridge road) the elevated currents amplitude (when amplitude is lower than interval limit) of conducting energy-storage capacitor, or the positive continuous current discharge electricity bridge road that conducting inductance coil and fly-wheel diode are formed (or anti-phase continuous current discharge electricity bridge road) reduces current amplitude (when amplitude is higher than interval limit), the defibrillation discharge current that one presents two-phase sawtooth square waveform is obtained with it thus patient, concrete steps are as follows:
The first step, appearance can shockable rhythm after advise defibrillation electric discharge, the charging completing energy-storage capacitor prepares, and sets discharge current parameter, comprises the reference interval value of discharge current amplitude, positive sawtooth waveforms sum and anti-phase sawtooth waveforms sum;
Second step, control bridge way switch, discharged to patient by positive bridge road by energy-storage capacitor, the current amplitude simultaneously flowing through inductance coil also progressively raises, and Real-time Feedback is on current sensor;
3rd step, prescribe a time limit when the discharge current on current sensor is elevated to the upper of preset reference interval, disconnect positive phase discharge bridge road, and pass through the positive afterflow bridge road of the formations such as positive bridge road low-side switch, inductance coil and fly-wheel diode, carry out continuous current discharge electricity by the inductance coil responded to, and Real-time Feedback is on current sensor;
4th step, disconnects positive continuous current discharge electricity bridge road in limited time when the discharge current on current sensor is reduced to the lower of preset reference interval, increases a sawtooth waveforms counting simultaneously, and compare with the positive sawtooth waveforms sum preset, as deficiency, then repeat the second ~ tetra-step;
5th step, after completing the electric discharge of positive sawtooth square wave, controls bridge way switch, by as the second ~ tetra-step, implements the electric discharge of anti-phase sawtooth square wave.
Adopt technique scheme, defibrillation waveform is not only less to patient's myocardial damage, and the synchronous defibrillation success rate that shocks by electricity also improves a lot; For the patient variation of different thorax impedance, the accurate shock energy of individuation more can be provided to control; The peak position simultaneously avoiding existing two phase exponential ripple, to the requirement of the higher starting voltage of high voltage discharge circuit, is conducive to reducing the cost of defibrillator high voltage electric discharge output stage and increasing the functional reliability of circuit.
Accompanying drawing explanation
Fig. 1 is the high pressure defibrillation electric discharge H bridge road schematic diagram of the embodiment of the present invention.
Fig. 2 is the defibrillation discharge process control flow chart of Fig. 1 embodiment.
Fig. 3 is the defibrillation discharge waveform schematic diagram of Fig. 1 embodiment.
Fig. 4 is automated external defibrillator device (AED) block diagram of Fig. 1 embodiment.
Fig. 5 is the defibrillation discharge waveform schematic diagram of Fig. 4 embodiment.
Detailed description of the invention
Set forth further below in conjunction with most preferred embodiment shown in the drawings and the present invention be described:
With reference to accompanying drawing 1, a kind of two-phase sawtooth square wave high-voltage discharge method for defibrillation, namely by comprising the defibrillator output stage 2 on a H bridge road, combine and control strategy with a series of bridge way switch S1 ~ S4 preset, by the electric energy in accumulator C via defibrillation electrode 3 with the impulse form 4 of two-phase sawtooth waveforms on patient body 1, (hereinafter referred to as being equivalent to Rp) carries out once high-voltage electric shock electric discharge rapidly, reach cessative aspect ventricular Fibrillation with this, realize the object that patient is rescued in time.The high pressure defibrillation charging method of the two-phase sawtooth square waveform of the present invention that the present embodiment adopts, provide a form and present the thin ripple of sawtooth to being in Fibrillated ventricular muscles and be superimposed upon defibrillation discharge current on two-phase square wave, for the defibrillation electric energy that patient provides individuation accurately to control, be conducive to the success rate improving the ventricle synchronous defibrillation of myocardial cell everywhere, effectively reduce in high pressure defibrillation procedure the damage that cardiac muscle is formed simultaneously.The concrete formation of the defibrillator output stage that the defibrillation charging method that the present invention provides is used and feature as follows:
Described defibrillator output stage 2, is made up of an at least one energy-storage capacitor C and four gauge tap S1 ~ S4; Wherein, four gauge tap S1 ~ S4 form H bridge type discharge circuit (at least comprising positive phase discharge bridge road S1-L-Rp-S3 and anti-phase electric discharge bridge road S2-Rp-L-S4), export the defibrillation current flow of diphasic pulse via defibrillation electrode 3 to patient 1;
Described defibrillator output stage 2, at least comprises an inductance coil L, this inductance coil and patient Rp H bridge in series road transverse arm;
Described defibrillator output stage 2, at least comprise a semiconductor diode (D1 ~ D4), this diode is in parallel with bridge way switch, has afterflow effect when switch disconnects;
Described defibrillator output stage 2, at least comprises positive (or anti-phase) the continuous current discharge electricity bridge road (L-Rp-S3-D4, or L-Rp-S4-D3) be made up of above-mentioned inductance coil L and above-mentioned fly-wheel diode L;
Described defibrillator output stage 2, at least comprises a current sensor (R
s+, R
s-), this current sensor is placed in a certain bridge road branch road, senses the current amplitude IP of this branch road in discharge process in real time;
With reference to accompanying drawing 2 and 3, utilize the high-voltage discharge method that above-mentioned H bridge road defibrillation output stage realizes, namely according to the thorax impedance of the shocked by electricity abnormal electrocardiogram information that detects and patient, automatically preset the defibrillation discharge waveform parameter (interval Imax+ ~ Imin+ of positive phase-current reference, anti-phase Imax-~ Imin-, positive sawtooth waveforms sum M and anti-phase sawtooth waveforms sum N), and export two-phase sawtooth square wave high-voltage electric shock electric current (I to patient immediately
p).It is characterized in that the current sensor (R in H bridge road
s+, R
s-) detect the amplitude of discharge current in electric defibrillation process in real time, and compare with the current amplitude reference interval value preset, and then pass through the positive phase discharge bridge road (S1-L-Rp-S3 of conducting energy-storage capacitor, or anti-phase electric discharge bridge road S2-Rp-L-S4) elevated currents amplitude (when amplitude is lower than interval limit), or the positive continuous current discharge electricity bridge road (L-Rp-S3-D4 that conducting inductance coil and fly-wheel diode are formed, or L-Rp-S4-D3 anti-phase continuous current discharge electricity bridge road) reduce current amplitude (when amplitude is higher than interval limit), the defibrillation discharge current that one presents two-phase sawtooth square waveform is obtained with it thus patient, its step is as follows:
First, appearance can shockable rhythm and advise defibrillation electric discharge after, the charging completing energy-storage capacitor prepares, and set discharge current parameter, comprise the reference interval value (positive phase-current reference interval Imax+ ~ Imin+, anti-phase Imax-~ Imin-) of discharge current amplitude, positive sawtooth waveforms sum M and anti-phase sawtooth waveforms sum N;
Secondly (
t 0 moment), control bridge way switch, discharged to patient by positive bridge road (S1-L-Rp-S3) by energy-storage capacitor, the current amplitude simultaneously flowing through inductance coil also progressively raises, and Real-time Feedback is to current sensor R
s+ on;
Again (
t 1 moment), as current sensor R
s+ on discharge current (I
p) be elevated to upper in limited time (Imax+) in preset reference interval, disconnect positive phase discharge bridge road, and by the positive afterflow bridge road that positive bridge road low-side switch, inductance coil and fly-wheel diode etc. are formed, carry out continuous current discharge electricity by the inductance coil responded to, and Real-time Feedback is on current sensor;
4th (
t 2 moment), (Imin-) is prescribed a time limit when the discharge current on current sensor is reduced to the lower of preset reference interval, disconnect positive continuous current discharge electricity bridge road (L-Rp-S3-D4), increase sawtooth waveforms counting (m+1) simultaneously, and with the positive sawtooth waveforms sum (M than) preset comparatively, as deficiency, then repeat 2nd ~ 4 steps;
5th, after completing the electric discharge of positive sawtooth pulse (
t 3 moment), control bridge way switch, by similar 2nd ~ 4 steps implement the electric discharge of anti-phase sawtooth pulse (
t 4 ~ t 6 moment).
With reference to accompanying drawing 4, adopt the embodiment of automated external defibrillator device (AED) block diagram of the present invention, its System's composition is: the main control module 8 based on MSP microprocessor is core, is connected respectively to the functional modules such as the physiological parameter acquisition such as electrocardio and thorax impedance module 5, human-computer interaction module 6, wireless communication module 7, high-voltage charging module 10, defibrillation electric discharge H bridge road module 18 by the corresponding interface; The unification of above-mentioned functions module is powered by lithium battery 9, and is all placed in an airtight frivolous high strength portable box body, is connected to patient body 1 by two defibrillation electrodes 3.Above-mentioned AED device can be operated in the daily circulation self-inspection state of battery saving mode and the electric defibrillation duty of first aid modes.During electric defibrillation duty, its primary control program or embedded OS unification control and coordinate each module work, comprise: preset personalized accurate discharge waveform parameter according to measured patient chest impedance information, once the ecg information of patient to be rescued passes through automatic analysis continuously, its result present can shockable rhythm time, primary control program will send charging instruction immediately and according to the two-phase sawtooth square wave high-voltage discharge method that the present invention provides, carry out the rescue of high-voltage electric shock defibrillation; In addition in whole rescue process, above-mentioned AED device by auxiliary in sound and light prompt, substep instructs rescuer to complete a series of save operations such as " being placed with electric shock, artificial respiration, CPR external chest compression, defibrillation electric discharge ", the information such as the ecg information of whole defibrillation rescue event, control instruction and device parameter also can all be deposited by said apparatus, carry out event replay and analysis for being exported by wireless communication module afterwards.Wherein, type selecting and the working method of described defibrillation electric discharge H bridge road output stage each main hardware part are as follows:
IGBT selected by described output stage H bridge road 18 high side switch (S1, S2), and low-side switch (S3, S4) selects thyrister form SCR switch, and S5 is electronics select switch, and H bridge way switch (S1 ~ S4) respectively arranges a set of current driver 14 ~ 17 simultaneously;
Described main control module 8 with the Low Power High Performance microprocessor MSP 430 of TI company for core, the sdram memory reservoir of expanding clock, 16MB, the flash storage of 1GB, 1.8V, 3.3V, ± 5V such as to power at the circuit unit, and UART, IIC, USB, JTAG, GPIO and as peripheral interfaces such as Radio infrareds;
Described time-sequence control mode 13 with XLINX company CPLD for core, by connecting an electronic comparator 12, compare the bridge road discharge current value that current reference value and actual measurement that main control module 8 sets are arrived continuously, and then the opening and closing of adjustment and control high side switch (S1 or S2).
With reference to accompanying drawing 5, the main control module 8 of above-mentioned AED device is based on the discharge waveform parameter set, the opening and closing of direct control low-side switch (S1 or S2), and indirectly control high side switch (S3 by CPD time-sequence control mode 13, S4) opening and closing, thus implement H bridge road of the present invention defibrillation charging method, realize exporting within the scope of certain amplitude in the discharge current of sawtooth square-wave waveform to patient; Final realization is quivered to room the fast effectively electric defibrillation of patient, saves the precious life of patient.
In the above-described embodiments, the functional modules such as the physiological parameter acquisition modules 5 such as the electrocardio of AED electric defibrillation device and thorax impedance, human-computer interaction module 6, wireless communication module 7, high-voltage charging module 10, electrode 3, drive circuit 14 ~ 17 and ECG automatic analysis and identification, each module communication agreement and primary control program, CPR assist the contents such as rescue method not to be content of the present invention, therefore do not provide and elaborate, specifically can realize with reference to correlation technique data and existing defibrillation Apparatus and system.