CN102764479B - Flexible nerve tract electrode and preparation method thereof - Google Patents
Flexible nerve tract electrode and preparation method thereof Download PDFInfo
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- CN102764479B CN102764479B CN201210243881.0A CN201210243881A CN102764479B CN 102764479 B CN102764479 B CN 102764479B CN 201210243881 A CN201210243881 A CN 201210243881A CN 102764479 B CN102764479 B CN 102764479B
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Abstract
The invention relates to a flexible nerve tract electrode, which comprises a flexible substrate, an electrode unit, an electrode lead, a lead welding spot and an insulating layer, wherein the electrode lead is electrically connected with the electrode unit and the lead welding spot; the electrode unit, the electrode lead and the lead welding spot form an electrode assembly together; the electrode assembly is arranged on the flexible substrate; the insulating layer is arranged on the flexible substrate and covers the electrode lead; and the electrode unit is electrically connected with a nerve tract. The invention also relates to a preparation method for the flexible nerve tract electrode. The flexible nerve tract electrode can be used for distinguishing moving nerve tracts and sensory nerve tracts in a nerve trunk, and can realize functions of a nerve cannula and provide space protection for growth of broken and injured nerves; functional electrical stimulation can be applied to the broken and injured nerves, so that the growth of the broken and injured nerves is accelerated; and the repair state of the broken and injured nerves can be monitored in real time by acquiring electrical physiological information at two ends of the broken and injured nerves. Moreover, the flexible nerve tract electrode can also be used for acquiring nerve information of normal nerve tracts to realize intelligent control of external instruments.
Description
Technical field
The present invention relates to field of medical device, particularly relate to a kind of flexible nerve tract electrode, also relate to a kind of preparation method of flexible nerve tract electrode.
Background technology
The disconnected wound of peripheral nervous is very common, and repairing the break the most frequently used method of wound of peripheral nervous at present clinically has two kinds: 1, for the situation that neurologic defect is larger, usually adopt the method for nerve autograft; 2, for the situation that neurologic defect is less, usually adopt end end sewing method, epineurium or nerve tract adventitia are sewed up.Peripheral nervous mostly is mixed nerve, and nerve tract is enclosed with the nerve fiber and various Sensory nerve fibre that connect different motion unit.Docking blindly may cause misconnection and the distortion of Sensory nerve fibre and Motor nerve fibre, thus causes the function of severed nerves not recover completely or residual certain dysfunction, so that clinical effectiveness is not good enough.In art, differentiate that disconnected to overtax one's nerves through intrafascicular nervus motorius and sensory nerve be the requirement become more meticulous of performing the operation fast and accurately, only making disconnected nervus motorius of overtaxing one's nerves through far and near two ends and sensory nerve para-position accurately, after just making operation in patients, limb functional recover maximizes.At present in the world without any one simply, fast, intuitively discrimination method can be applied to clinical, clinician can only by virtue of experience coincide break overtax one's nerves through two ends, surgical outcome is overly dependent upon the clinical experience of doctor.
Neuranagenesis has selectivity, reserves the space for the regeneration of its selectivity, will be conducive to neuranagenesis between two broken ends of fractured bone of nerve docking.Adopt neural sleeve pipe can build the microenvironment of neuranagenesis, be conducive to exogenous, endogenous factors or cells play effect, impel neural near-end optionally to grow into far-end, realize severed nerves and dock accurately, thus promote the recovery of function of nervous system.In addition, neural sleeve pipe is adopted can also to realize the fixing of two broken ends of fractured bone.At present, the material for neural sleeve pipe is mainly divided into two large classes, and a class is the natural materials such as biomembrane, vein, tremulous pulse, epineurium pipe, hyalomitome acid tube, amniotic membrane, and another kind of is the synthetic materials such as silica gel tube, polyglycolic acid, polyglycolic acid pipe.Clinical practice shows, the neural sleeve pipe of simple this physical property of use, CO2 laser weld speed is not satisfactory, and sensation or Motion missing can cause amyotrophy, arthrogryposis deformity etc. for a long time.The sleeve pipe of this physical property cannot identify nervus motorius in nerve tract and sensory nerve in art in addition, does not also possess the function of information gathering, is difficult to the real-time monitoring realizing neurotmesis being repaired to state.
Suitable electricity irritation can activate injured neurons effectively, the regeneration of guiding and accelerator nerve, and nerve tract electrode is also applied to repairing neurotmesis clinically.Nerve tract electrode the most frequently used is at present puncture type single channel needle electrode, and this kind of electrode can sting nerve tract adventitia and reach nerve tract inside.On the one hand, it as recording electrode, can gather the bioelectrical activity information of nerve tract, is sent to external electronic device and carries out analyzing and processing; On the other hand, it as stimulating electrode, can apply functional electrical stimulation by it to nerve tract, realizes the neural regulation and control in periphery.The advantage of this electrode is simple closer to target neural cells, method for implantation; Shortcoming to cause neural tissue injury, and simple this electrode that uses cannot realize the fixing of severed nerves two ends.
Summary of the invention
Based on this, be necessary, for traditional neural sleeve pipe and puncture type single channel needle electrode Problems existing, to provide a kind of flexible nerve tract electrode.
A kind of flexible nerve tract electrode, comprise flexible substrates, electrode unit, contact conductor, lead solder-joint and insulating barrier, described contact conductor is electrically connected described electrode unit and lead solder-joint, described electrode unit, contact conductor and lead solder-joint form electrode assemblie jointly, described electrode assemblie is located in described flexible substrates, described insulating barrier to be located in described flexible substrates and to be covered described contact conductor, and described electrode unit is for being electrically connected nerve tract.
Wherein in an embodiment, the material of described flexible substrates and insulating barrier is polydimethylsiloxane.
Wherein in an embodiment, described electrode assemblie comprises electrode layer, and the material of described electrode layer is one or more in gold, titanium, copper.
Wherein in an embodiment, described electrode assemblie also comprises prime coat and decorative layer, and described electrode layer is located on described prime coat, and described decorative layer is located on described electrode layer; The material of described prime coat is titanium, chromium, or comprises one or both the alloy in these two kinds of elements; The material of described decorative layer is platinum, iridium, or one or both the alloy comprised in these two kinds of elements or compound.There is a need to the preparation method that a kind of flexible nerve tract electrode is provided.
A preparation method for flexible nerve tract electrode, comprises the following steps: step one, rigid basement arranges polydimethylsiloxane and forms flexible substrates; Step 2, described flexible substrates forms electrode assemblie, and described electrode assemblie comprises lead solder-joint, for being electrically connected the electrode unit of nerve tract and being electrically connected described lead solder-joint and electrode unit contact conductor; Step 3, described flexible substrates arranges the polydimethylsiloxane covering described electrode assemblie and forms insulating barrier, and form opening at the electrode unit of described insulating barrier and lead solder-joint position, expose described electrode unit and lead solder-joint; Step 4, is separated described flexible substrates with rigid basement.
Wherein in an embodiment, described step 2 comprises: deposit conducting film in described flexible substrates; On described conducting film, photoetching forms the photoetching agent pattern of described electrode assemblie; Wet etching also removes described photoetching agent pattern, forms described electrode unit, contact conductor and lead solder-joint.
Wherein in an embodiment, described step 2 comprises: prepare one piece of mask, mask is formed the pierced pattern of described electrode assemblie; Described mask is placed in described flexible substrates, is formed and closely attach; Deposit conducting film in described flexible substrates; Remove described mask, described conducting film forms described electrode assemblie after mask removes.
Wherein in an embodiment, described step 2 comprises: photoetching in described flexible substrates, forms the reversal photoresist pattern of described electrode assemblie as the first photoetching glue victim layer; In described flexible substrates, deposit forms conducting film; Remove described first photoetching glue victim layer, the part that described conducting film is positioned on described first photoetching glue victim layer is peeled off in the lump, forms described electrode assemblie.
Wherein in an embodiment, described step 3 comprises: photoetching in described flexible substrates, thus forms the second photoetching glue victim layer at described electrode unit and lead solder-joint surface; Described flexible substrates arranges polydimethylsiloxane and forms described insulating barrier; Remove described second photoetching glue victim layer, the part that described insulating barrier is positioned on described second photoetching glue victim layer is peeled off in the lump, forms described opening.
Wherein in an embodiment, the thickness of described second photoetching glue victim layer is greater than the thickness of described insulating barrier.
Wherein in an embodiment, described step 3 comprises:
Adopt the method for cut or ion etching to carry out cutting or corroding at the electrode unit of insulating barrier and lead solder-joint position, directly the insulating barrier on removal electrode unit and lead solder-joint surface, realizes opening.
Above-mentioned flexible nerve tract electrode, curling stitching can realize the function of neural sleeve pipe, for the selective growth of severed nerves provides space protection afterwards.Can by applying electricity irritation and recording responses situation to disconnected diverse location of hindering nerve tract outer periphery in art, thus identification nerve tract is disconnected hinders face nervus motorius and sensorineural distribution situation, realize disconnectedly overtaxing one's nerves through the Dock With Precision Position at two ends.Functional electrical stimulation can also be applied to severed nerves, accelerate the growth of severed nerves; Or by overtaxing one's nerves through the collection of two ends electrophysiology information to disconnected, monitoring is in real time disconnected overtax one's nerves through reparation state.Compared with the puncture type electrode of current clinical employing, can not damage target nerve Shu Zaocheng.This electrode material is owing to having good biocompatibility in addition, can be used for implanting for a long time, if necessary, after Rehabilitation, also can take out electrode by operation.
In addition, this flexible nerve tract electrode, can also by obtaining the nerve information of healthy nerve tract except hindering except the reparation of nerve tract for disconnected, for the prosthesis control etc. of neural machine interface and people with disability.Neural machine interface is decoded to it by the signal of telecommunication obtaining neuron granting, is classified, and then sorted result be encoded into various control command to control external equipment as: computer for controlling, artificial limb or other intelligent apparatuses, realize the control of nerve signal to external environment condition.
Accompanying drawing explanation
Fig. 1 is the schematic diagram of the flexible nerve tract electrode of circulating type structure in an embodiment;
Fig. 2 is the sectional view along dotted line 6 shown in Fig. 1;
Fig. 3 is the sectional view along dotted line 7 shown in Fig. 1;
Fig. 4 is the flow chart of the preparation method of flexible nerve tract electrode in an embodiment;
Fig. 5 is the flow chart of the preparation method of flexible nerve tract electrode in another embodiment;
Fig. 6 is the flow chart of the preparation method of flexible nerve tract electrode in another embodiment;
Fig. 7 is the flow chart of the preparation method of flexible nerve tract electrode in another embodiment;
Fig. 8 is the schematic diagram of the flexible nerve tract electrode of folded structure in an embodiment;
Fig. 9 is the sectional view along dotted line 15 shown in Fig. 8;
Figure 10 is the sectional view along dotted line 16 shown in Fig. 8;
Figure 11 is the design sketch that the flexible nerve tract electrode of circulating type structure shown in Fig. 1 in an embodiment acts on target nerve bundle;
Figure 12 is that the flexible nerve tract electrode of circulating type structure shown in Fig. 1 in another embodiment is according to the structural representation of the curling neural sleeve pipe of target nerve bundle size;
Figure 13 is that the neural sleeve pipe shown in Figure 12 acts on disconnected design sketch of hindering nerve tract;
Figure 14 is the design sketch that the flexible nerve tract electrode of folded structure shown in Fig. 8 in an embodiment acts on target nerve bundle;
Figure 15 is that the flexible nerve tract electrode of folded structure shown in Fig. 8 in another embodiment is according to the structural representation of the curling neural sleeve pipe of target nerve bundle size;
Figure 16 is that the neural sleeve pipe shown in Figure 15 acts on disconnected design sketch of hindering nerve tract.
Detailed description of the invention
For enabling object of the present invention, feature and advantage more become apparent, and are described in detail the specific embodiment of the present invention below in conjunction with accompanying drawing.
Fig. 1 is the schematic diagram of the flexible nerve tract electrode of circulating type structure in an embodiment, and flexible nerve tract electrode comprises flexible substrates 1, insulating barrier 2, electrode unit 3, contact conductor 4 and lead solder-joint 5.Contact conductor 4 electrode electrically connected unit 3 and lead solder-joint 5, electrode unit 3, contact conductor 4 and an a lead solder-joint 5 composition electrode assemblie jointly.Electrode assemblie is located in flexible substrates 1, and insulating barrier 2 to be located in flexible substrates 1 and coated electrode lead-in wire 4.Electrode unit 3 is for being electrically connected target nerve bundle.Electrode unit 3 may be used for applying electricity irritation to nerve tract, can also be used for the electrophysiology information gathering nerve tract.
The scope of application of above-mentioned flexible nerve tract electrode is comparatively wide, has both gone for normal neuronal bundle, goes for again the nerve tract damaging (comprising disconnected wound).Curling stitching can realize the function of neural sleeve pipe afterwards, for disconnected overtax one's nerves through selective growth space protection is provided.Electricity irritation can be applied to disconnected nerve tract of hindering, distinguish sensory nerve and nervus motorius in nerve tract.Can also overtaxing one's nerves through applying functional electrical stimulation to disconnected, accelerating the growth of injured nerve; Or by overtaxing one's nerves through the collection of two ends electrophysiology information to disconnected, monitoring is in real time disconnected overtax one's nerves through reparation state.When for repair disconnected hinder nerve tract, this flexible nerve tract electrode can as the bi-directional platform stimulating-record, and overtax one's nerves through proximal electrode for stimulating electrode with disconnected, remote electrode is recording electrode, measure stimulation-response curve, with this assess disconnected overtax one's nerves through reparation state.
Wherein in an embodiment, the material of flexible substrates 1 and insulating barrier 2 is polydimethylsiloxane (polydimethylsiloxane).Polydimethylsiloxane has good pliability and deformability and good biocompatibility, and can ensure micro-meter scale machining accuracy and the spatial resolution of flexible nerve tract electrode.Therefore, polydimethylsiloxane is adopted to make flexible nerve tract electrode have good pliability and can degree of drawing as the material of flexible substrates 1 and insulating barrier 2, can ensure that electrode and target nerve bundle form good electrical contact, can avoid again in nerve tract growth course because the rigidity of sleeve pipe produces stress in nerve tract inside, and then the self-sow state of the bundle that affects the nerves even causes damage, also can not expand and pressuring nerve along with nerve growth.And flexible nerve tract electrode can realize the minimum machining accuracy to micro-meter scale and spatial resolution, the number of electrodes in electrod-array also can increase as required, and does not increase extra cost of manufacture.With puncture type single channel needle electrode with sew up electrode wire form cuff electrode that tinsel formed as electrode by comparison on the silicone rubber sleeve inside pipe wall of molding, the number of sites, space fine degree etc. of information gathering and electricity irritation regulation and control all can have and significantly improve.
The material of electrode unit 3, contact conductor 4 and lead solder-joint 5 can be one or more in gold, platinum, titanium, iridium, chromium, copper, or the alloy of one or more comprised in gold, platinum, titanium, iridium, chromium, copper or compound.Wherein in an embodiment, electrode assemblie comprises electrode layer, and the material of electrode layer is one or more in gold, titanium, copper.In another embodiment, electrode assemblie also comprises prime coat and decorative layer, and electrode layer is located on prime coat, and decorative layer is located on electrode layer.The material of prime coat is titanium, chromium, or comprises one or both the alloy in these two kinds of elements.The material of decorative layer is platinum, iridium, or one or both the alloy comprised in these two kinds of elements or compound.
Fig. 2 is the sectional view along dotted line 6 shown in Fig. 1, and Fig. 3 is the sectional view along dotted line 7 shown in Fig. 1.In this embodiment, electrode unit 3 and lead solder-joint 5 are exposed to the external world, and insulating barrier 2 is not established on surface.The quantity of electrode assemblie is 20, and this flexible nerve tract electrode adopts circulating type structure, and the lead solder-joint 5 of electrode assemblie is arranged in the matrix of 1*20, and electrode unit 3 is arranged in the matrix of 2*10.Electrode unit 3 is for realizing the electrical connection of flexible nerve tract electrode and target nerve interfascicular, lead solder-joint 5 is for realizing the electrical connection between flexible nerve tract electrode and external circuit, therefore the upper opening of electrode unit 3 and lead solder-joint 5, does not arrange insulating barrier 2 structure.Contact conductor 4 is sandwiched in the middle of flexible substrates 1 and insulating barrier 2, forms a sandwich structure.
Fig. 4 is the flow chart of the preparation method of flexible nerve tract electrode in an embodiment, comprises the following steps:
S110, rigid basement arranges polydimethylsiloxane and forms flexible substrates 1.
Rigid basement can select glass, silicon chip etc., mainly plays a part to support.In the present embodiment, rigid basement adopts silicon chip (can be any crystal orientation), and adopts the mode of spin coating that polydimethylsiloxane is arranged on silicon chip surface.The method wherein changing flexible substrates 1 thickness mainly contains two kinds: one changes spin speed, and another is the concentration changing polydimethylsiloxane.
S120, forms electrode unit 3, contact conductor 4 and lead solder-joint 5 on a flexible substrate.
An electrode unit 3, contact conductor 4 and a lead solder-joint 5 form an electrode assemblie, and electrode unit 3 and lead solder-joint 5 are electrically connected by contact conductor 4.The material of electrode assemblie is one or more in gold, platinum, titanium, iridium, chromium, copper, or the alloy of one or more comprised in gold, platinum, titanium, iridium, chromium, copper or compound.Wherein in an embodiment, electrode assemblie at least comprises electrode layer, and the material of electrode layer is one or more in gold, titanium, copper.Wherein in an embodiment, electrode assemblie also comprises prime coat and decorative layer, and electrode layer is located on prime coat, and decorative layer is located on electrode layer.The material of prime coat is titanium, chromium, or comprises one or both the alloy in these two kinds of elements.The material of decorative layer is platinum, iridium, or one or both the alloy comprised in these two kinds of elements or compound.
S130, the polydimethylsiloxane that flexible substrates 1 arranges coated electrode assembly forms insulating barrier 2, and forms opening at the electrode unit 3 of insulating barrier 2 and lead solder-joint 5 position, electrode unit 3 and lead solder-joint 5 is exposed.
Insulating barrier 2 can be arranged by the method for spin coating equally, and the thickness of insulating barrier 2 also can be adjusted by the method for the concentration changing spin speed or change polydimethylsiloxane.
S140, is separated flexible substrates 1 with rigid basement.
The flexible nerve tract electrode adopting the preparation method of above-mentioned flexible nerve tract electrode to prepare, has good size adaptability, is easy to the normalization design realizing device.
See Fig. 5, in another embodiment, the preparation method of flexible nerve tract electrode specifically comprises the following steps:
S111, on the silicon chip in any crystal orientation, spin coating polydimethylsiloxane is as flexible substrates 1.
In the present embodiment, flexible substrates 1 thickness is 100 μm.
S121, deposit conducting film in flexible substrates 1.
In the present embodiment, the conducting film decorative layer that comprises prime coat, be located at the electrode layer on prime coat and be located on electrode layer.First adopt magnetron sputtering in flexible substrates 1, to deposit one deck chromium film as prime coat, thickness is 3nm; Then on prime coat, plate one deck gold film again as electrode layer, thickness is 40nm; Adopt electrochemical method again at the plated surface last layer platinum black of electrode layer as decorative layer.
S123, on conducting film, photoetching forms the photoetching agent pattern of electrode unit 3, contact conductor 4 and lead solder-joint 5.
S125, wet etching also removes photoetching agent pattern, forms electrode unit 3, contact conductor 4 and lead solder-joint 5.
In the present embodiment, successively carry out etching conductive film by the corrosive liquid of gold and chromium, utilize photoresist to the blocking effect of corrosion, retain the visuals of electrode assemblie, the conducting film of remainder is eroded.Etch rear removal photoetching agent pattern, obtain required electrode assemblie.
S131, in the flexible substrates 1 preparing microelectrode array 3, contact conductor 4 and lead solder-joint 5, spin coating polydimethylsiloxane is as insulating barrier 2.
In the present embodiment, the thickness of insulating barrier 2 is 10 μm.
S133, adopts the mode of cut to remove the insulating barrier 2 on electrode unit 3 and lead solder-joint 5 surface, realizes opening.
S140, is separated flexible substrates 1 with rigid basement.
Fig. 6 is the flow chart of the preparation method of flexible nerve tract electrode in another embodiment, and itself and the main distinction embodiment illustrated in fig. 5 are have employed peels off (lift-off) technique, comprises the following steps:
S111, on the silicon chip in any crystal orientation, spin coating polydimethylsiloxane is as flexible substrates 1.
In the present embodiment, flexible substrates 1 thickness is 100 μm.
S122, in flexible substrates 1, photoetching forms the reversal photoresist pattern of electrode unit 3, contact conductor 4 and lead solder-joint 5 as the first photoetching glue victim layer.
S124, in flexible substrates 1, deposit forms conducting film.
In the present embodiment, conducting film adopts double-decker, and ground floor is prime coat, and material is titanium, and the second layer is electrode layer, and material is gold.Deposit specifically can adopt the technique of electron beam evaporation, and first on flexible substrates 1, deposit layer of metal titanium film is as prime coat, and thickness is 3nm, and then deposit one deck gold film is as electrode layer, and thickness is 40nm.。The thickness of the first photoetching glue victim layer should be greater than the thickness of conducting film, to obtain preferably peeling effect.
S126, removes the first photoetching glue victim layer, and the part that conducting film is positioned on the first photoetching glue victim layer is peeled off in the lump, forms electrode unit 3, contact conductor 4 and lead solder-joint 5.
S132, photoetching in flexible substrates 1, thus form the second photoetching glue victim layer at electrode unit 3 and lead solder-joint 5 surface.
S134, arranges polydimethylsiloxane on a flexible substrate and forms insulating barrier 2.
The polydimethylsiloxane of spin coating one deck coated electrode unit 3, contact conductor 4 and lead solder-joint 5 is as insulating barrier 2, and the thickness of insulating barrier 2 should far below the thickness of the second photoetching glue victim layer, and namely the second photoetching glue victim layer should adopt thicker photoresist.
S136, removes the second photoetching glue victim layer, and the part that insulating barrier 2 is positioned at the second photoetching glue victim layer surface is peeled off in the lump, forms opening.
S140, is separated flexible substrates 1 with rigid basement.
Fig. 7 is the flow chart of the preparation method of flexible nerve tract electrode in another embodiment, comprises the following steps:
S111, on the silicon chip in any crystal orientation, spin coating polydimethylsiloxane is as flexible substrates 1.
S127, prepares one piece of mask plate, and the pattern of mask is the pierced pattern of electrode assemblie.Namely the hollow part of mask is consistent with the pattern of the electrode assemblie that flexible nerve tract electrode will be formed.
S128, is placed in mask in flexible substrates, is formed and closely attaches, and to deposit conducting film in flexible substrates under the stop of mask.
In the present embodiment, conducting film is electrode layer, and adopt magnetron sputtering to carry out this electrode layer of gold-plated formation, thickness is 40nm.
S129, removes mask, and conducting film forms electrode assemblie after mask removes.
S131, in the flexible substrates 1 preparing electrode assemblie, spin coating one deck polydimethylsiloxane is as insulating barrier 2.In the present embodiment, the thickness of insulating barrier is 10 μm.
S137, adopts the method for ion etching to remove the polydimethylsiloxane on electrode unit 3 and lead solder-joint 5 surface, forms opening.
S140, is separated flexible substrates with rigid basement.
In one embodiment, step S130 arranges one deck photaesthesia polydimethylsiloxane (photopatternable PDMS) to form insulating barrier 2 in flexible substrates 1, and photaesthesia polydimethylsiloxane is carried out photoetching as photoresist, at electrode unit 3 and the lead solder-joint 5 position formation opening of insulating barrier 2, electrode unit 3 and lead solder-joint 5 are exposed.
Fig. 8 is the schematic diagram of the flexible nerve tract electrode of folded structure in an embodiment, and itself and the main distinction embodiment illustrated in fig. 1 are that the structure of electrode assemblie is different.As shown in Figure 8, the cross section of flexible nerve tract electrode is rectangle, the electrode assemblie be made up of electrode unit 12, contact conductor 13 and lead solder-joint 14 comprises is located at the first electrode assemblie of flexible nerve tract electrode side and the second electrode assemblie of opposite side, and the lead solder-joint 14 of the first electrode assemblie and the second electrode assemblie is arranged near two opposite side of flexible nerve tract electrode respectively.In this embodiment, the first electrode assemblie and the second electrode assemblie are respectively 10, and lead solder-joint 14 is arranged into the matrix of 2*10.In addition, in this embodiment, the material of electrode assemblie is titanium.Flexible substrates 10 is then similar to embodiment illustrated in fig. 1 with the structure of insulating barrier 11.
Fig. 9 is the sectional view along dotted line 15 shown in Fig. 8, and Figure 10 is the sectional view along dotted line 16 shown in Fig. 8.As shown in the figure, electrode unit 12 and lead solder-joint 14 are exposed to the external world, and insulating barrier 11 is not established on surface.
It is pointed out that the preparation method of above-mentioned flexible nerve tract electrode is all equally applicable to manufacture the flexible nerve tract electrode of middle folded structure embodiment illustrated in fig. 8.
Introduce the using method of flexible nerve tract electrode below:
Figure 11 is the design sketch that the flexible nerve tract electrode of circulating type structure shown in Fig. 1 in an embodiment acts on target nerve bundle.In this embodiment, the using method of flexible nerve tract electrode comprises the following steps:
1) flexible nerve tract electrode is directly wound around target nerve bundle 8, the one side (namely flexible nerve tract electrode is provided with the one side of insulating barrier 2) that electrode unit 3 is exposed towards and be close to nerve tract adventitia, the one side that flexible nerve tract electrode is provided with flexible substrates 1 is outside.The nerve tract be suitable in this embodiment can be complete nerve tract, also can be the nerve tract of damage, and comprising breaks hinders nerve tract.Hinder nerve tract for disconnected, flexible nerve tract electrode can be wound around two fracture ends of nerve tract simultaneously, two fracture ends are all wrapped up within it.
2) flexible nerve tract electrode and nerve tract adventitia are stitched together, realize the fixing of flexible nerve tract electrode and target nerve bundle 8 relative position, avoid flexible nerve tract electrode to launch to come off, or slide on target nerve bundle 8.Suture location 9 need dodge electrode unit 3, contact conductor 4 and lead solder-joint 5.Hinder nerve tract for disconnected, need respectively two of nerve tract fracture ends to be stitched together with flexible nerve tract electrode.
Figure 12 is that the flexible nerve tract electrode of circulating type structure shown in Fig. 1 in another embodiment is according to the structural representation of the curling neural sleeve pipe of target nerve bundle size; Figure 13 is that the neural sleeve pipe shown in Figure 12 acts on disconnected design sketch of hindering nerve tract.In this embodiment, the using method of flexible nerve tract electrode comprises the following steps:
1) according to the outside dimension of target nerve bundle 19, the flexible nerve tract electrode of circulating type structure is curled into neural sleeve pipe, wherein the internal diameter of neural sleeve pipe need match with the outside dimension of target nerve bundle 19, and the one side that electrode unit 3 exposes is as inside sleeve pipe.
2) flexible nerve tract electrode is sewed up fixing according to curling good nerve cuff bore size.Suture location 18 need dodge electrode unit 3, contact conductor 4 and lead solder-joint 5.
3) the first fracture end 21 and the second fracture end 22 of hindering nerve tract (i.e. target nerve bundle 19) by breaking are inserted from the both sides of neural sleeve pipe respectively, make it toward each other.The space for its regeneration can be reserved between two fracture ends.
4) adventitia of two fracture ends is combined with nerve cuff pipe seam respectively, object is the relative position of fixing neural sleeve pipe and target nerve bundle 19, avoid nerve tract fracture end to skid off in neural sleeve pipe, the suture location 20 that this secondary is sewed up need dodge electrode unit 3, contact conductor 4 and lead solder-joint 5.
Above-mentioned flexible nerve tract electrode can adjust the internal diameter of curling neural sleeve pipe before use according to the size of target nerve bundle, therefore compared with the neural sleeve pipe of current clinical employing, choose from the sleeve pipe of each specification when the specification not needing to process the sleeve pipe fixed in advance is to be used, the nerve tract therefore for different thicknesses all has good wide usage again.Because material of main part is polydimethylsiloxane, soft and be easy to penetrate, be therefore easy to sew application.
Figure 14 is the design sketch that the flexible nerve tract electrode of folded structure shown in Fig. 8 in an embodiment acts on target nerve bundle.In this embodiment, the using method of flexible nerve tract electrode comprises the following steps:
1) flexible nerve tract electrode is directly wound around target nerve bundle 8, the one side (namely flexible nerve tract electrode is provided with the one side of insulating barrier 11) that electrode unit 12 is exposed towards and be close to nerve tract adventitia, the one side that flexible nerve tract electrode is provided with flexible substrates 10 is outside.The nerve tract that this embodiment is suitable for can be complete nerve tract, also can be the nerve tract of damage, and comprising breaks hinders nerve tract.Hinder nerve tract for disconnected, flexible nerve tract electrode can be wound around two fracture ends of nerve tract simultaneously, two fracture ends are all wrapped up within it.
2) flexible nerve tract electrode and nerve tract adventitia are stitched together, realize the fixing of flexible nerve tract electrode and target nerve bundle 8 relative position, avoid flexible nerve tract electrode to launch to come off, or slide on target nerve bundle 8.Suture location 17 need dodge electrode unit 12, contact conductor 13 and lead solder-joint 14.Hinder nerve tract for disconnected, need respectively two of nerve tract fracture ends to be stitched together with flexible nerve tract electrode.
Figure 15 is that the flexible nerve tract electrode of folded structure shown in Fig. 8 in another embodiment is according to the structural representation of the curling neural sleeve pipe of target nerve bundle size; Figure 16 is that the neural sleeve pipe shown in Figure 15 acts on disconnected design sketch of hindering nerve tract.In this embodiment, the using method of flexible nerve tract electrode comprises the following steps:
1) according to the outside dimension of target nerve bundle 19, the flexible nerve tract electrode of circulating type structure is curled into neural sleeve pipe, wherein the internal diameter of neural sleeve pipe and the outside dimension of target nerve bundle 19 match, and the one side that electrode unit 12 exposes is as inside sleeve pipe.
2) flexible nerve tract electrode is sewed up fixing according to curling good nerve cuff bore size.Suture location 23 need dodge electrode unit 12, contact conductor 13 and lead solder-joint 14.
3) the first fracture end 21 and the second fracture end 22 of hindering nerve tract (i.e. target nerve bundle 19) by breaking are inserted from the both sides of neural sleeve pipe respectively, make it toward each other.The space for its regeneration can be reserved between two fracture ends.
4) adventitia of two fracture ends is combined with nerve cuff pipe seam respectively, object is the relative position of fixing neural sleeve pipe and target nerve bundle 19, avoid nerve tract fracture end to skid off in neural sleeve pipe, the suture location 24 that secondary is sewed up need dodge electrode unit 12, contact conductor 13 and lead solder-joint 14.
In addition, adopt above-mentioned flexible nerve tract electrode can distinguish disconnected Motor nerve fibre and Sensory nerve fibre of hindering nerve tract two ends, being convenient to realizes breaking overtaxes one's nerves through the Dock With Precision Position at two ends.When flexible nerve tract electrode bridge joint is fixing disconnected hinder nerve tract two ends time, severed nerves far-end and near-end have a circle electrode parcel.When applying electricity irritation, severed nerves near-end sensigenous reacts, and far-end causes muscle contraction to react, and the nerve tract that therefore corresponding electrode of feeling signal and the generation of muscle contraction signal covers is respectively sensory nerve bundle and motor tract.Thus reach the sensory nerve bundle of differentiation two fracture end and the object of motor tract.
The above embodiment only have expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but therefore can not be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (4)
1. a flexible nerve tract electrode, it is characterized in that, comprise flexible substrates, electrode unit, contact conductor, lead solder-joint and insulating barrier, described contact conductor is electrically connected described electrode unit and lead solder-joint, described electrode unit, contact conductor and lead solder-joint form electrode assemblie jointly, described electrode assemblie is located in described flexible substrates, described insulating barrier to be located in described flexible substrates and to be covered described contact conductor, described flexible nerve tract electrode is stitched together for being wound around target nerve Shu Bingyu nerve tract adventitia, the one side that wherein said electrode unit exposes towards and be close to nerve tract adventitia to be electrically connected nerve tract, the one side that flexible nerve tract electrode is provided with flexible substrates is outside.
2. flexible nerve tract electrode according to claim 1, is characterized in that, the material of described flexible substrates and insulating barrier is polydimethylsiloxane.
3. flexible nerve tract electrode according to claim 1, is characterized in that, described electrode assemblie comprises electrode layer, and the material of described electrode layer is one or more in gold, titanium, copper.
4. flexible nerve tract electrode according to claim 3, is characterized in that, described electrode assemblie also comprises prime coat and decorative layer, and described electrode layer is located on described prime coat, and described decorative layer is located on described electrode layer;
The material of described prime coat is titanium, chromium, or comprises one or both the alloy in these two kinds of elements;
The material of described decorative layer is platinum, iridium, or one or both the alloy comprised in these two kinds of elements or compound.
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| CN102980926B (en) * | 2012-11-28 | 2015-04-29 | 清华大学 | Preparation method of flexible double-faced full-solid ion concentration detection sensor |
| CN103202690B (en) * | 2013-03-14 | 2015-04-15 | 深圳先进技术研究院 | Flexible epicardium electrocardio-electrode chip and preparation method thereof |
| CN103462601B (en) * | 2013-09-24 | 2016-06-15 | 深圳先进技术研究院 | Electrode for medical service pastes and preparation method thereof |
| CN106388807B (en) * | 2016-08-30 | 2019-12-20 | 中国科学院深圳先进技术研究院 | Preparation method of surface-attached electrode array |
| CN106377246B (en) * | 2016-08-30 | 2019-06-25 | 中国科学院深圳先进技术研究院 | A kind of electrod-array and preparation method thereof |
| CN108939287B (en) * | 2018-06-04 | 2020-09-04 | 清华大学 | Method for manufacturing flexible spiral electrode and nerve bundle detection and treatment device |
| CN108853717B (en) * | 2018-06-19 | 2022-03-22 | 国家纳米科学中心 | Flexible nerve electrode and implantation method thereof |
| CN109044326B (en) * | 2018-06-26 | 2021-07-23 | 中国科学院深圳先进技术研究院 | Printing technology-based fully-flexible dry electrode and preparation method thereof |
| CN110464983B (en) * | 2019-08-19 | 2020-05-15 | 清华大学 | Degradable flexible nerve bundle repairing device |
| CN111812173A (en) * | 2020-09-07 | 2020-10-23 | 博睿康科技（常州）股份有限公司 | Intelligent electrode |
| CN113724920B (en) * | 2021-08-31 | 2022-05-31 | 苏州景昱医疗器械有限公司 | Flexible conductive soft board and manufacturing method thereof, stimulation electrode and manufacturing method thereof |
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| CN102499666A (en) * | 2011-10-17 | 2012-06-20 | 上海交通大学 | Neural microelectrode with rigid and flexible structures |
| CN102544052A (en) * | 2012-03-08 | 2012-07-04 | 中国科学院深圳先进技术研究院 | Flexible intracranial cortex microelectrode chip, and preparation method and packaging method and packaging structure thereof |
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| CN102499666A (en) * | 2011-10-17 | 2012-06-20 | 上海交通大学 | Neural microelectrode with rigid and flexible structures |
| CN102544052A (en) * | 2012-03-08 | 2012-07-04 | 中国科学院深圳先进技术研究院 | Flexible intracranial cortex microelectrode chip, and preparation method and packaging method and packaging structure thereof |
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