CN102284094A - Non-drug therapy system for septicopyemia caused by drug-resistance bacteria - Google Patents
Non-drug therapy system for septicopyemia caused by drug-resistance bacteria Download PDFInfo
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- CN102284094A CN102284094A CN2011101971841A CN201110197184A CN102284094A CN 102284094 A CN102284094 A CN 102284094A CN 2011101971841 A CN2011101971841 A CN 2011101971841A CN 201110197184 A CN201110197184 A CN 201110197184A CN 102284094 A CN102284094 A CN 102284094A
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Abstract
The invention relates to a non-drug therapy system for septicopyemia caused by drug-resistance bacteria, which is structurally characterized by comprising a blood plasma collector, a disposable mechanically collected plasma separating and pathogen inactivating multipurpose treater and a high hydrostatic pressure (HHP) plasma pathogen inactivating instrument, wherein the disposable mechanically collected plasma separating and pathogen inactivating multipurpose treater comprises a blood collector, a pipeline, a plasma separating cup, a tubular plasma collecting and ultrahigh pressure inactivating processing bag, a puncturing cap, a hemostatic clamp, a blood filter, a pressure monitor, a saline water back transfusion needle and a protective cap thereof and an anticoagulant and a protective cap thereof. In the non-drug therapy system for the septicopyemia caused by the drug-resistance bacteria, the blood plasma collector and the HHP plasma pathogen inactivating instrument in the prior art are connected and combined by using a treater designed by an inventer and installing an operational program to realize plasma pathogen inactivating by system integration, and discontinuous closed transfusion treatment is carried out on plasma of which the pathogen is inactivated at an ultrahigh pressure to achieve the goal of anti-pathogen therapy. The on-drug therapy system for the septicopyemia caused by the drug-resistance bacteria has a wide pathogen inactivating spectrum and low cost and is safe and effective.
Description
Technical field
This is non-medicine fastbacteria pyaemia septica therapy system for the present invention, belongs to infectious disease treatment, safe transfusion, blood products field.
Background technology
The microorganism that after secular antibiotic is selected, occurs to corresponding antibiotic generation tolerance, the general designation fastbacteria.So-called drug-resistance of bacteria is meant antibacterial repeatedly with after medicine contact, and the sensitivity of medicine is reduced even disappears, and causes medicine to the curative effect reduction of fastbacteria even invalid.The forties, penicillin is applied to clinical antibiotic as first kind, has successfully solved golden clinically Portugal bacterium and has infected this difficult problem.The Macrolide of Wen Shiing subsequently, aminoaglycon antibiotics makes pneumonia, phthisical mortality rate reduce by 80% again, and once the someone asserted at that time: the mankind defeat the epoch of antibacterial to arrive.But true and fine unlike people's imagination, many antibiotic drug effect in various degree occurred and have lowered after using for many years, and natural penicillin is almost losing medical value aspect the control golden Portugal bacterium infection.The physician surprisingly finds after this phenomenon of research, after contact repeatedly with antibiotic, and antibacterial a whole set of effective resistance mechanism of having evolved out, this hiding in the dark enemy is powerful gradually for fastbacteria.
In China, the situation of abuse of antibiotics is also very general, and according to investigations, China outpatient service flu patient has 75% to use antibiotic approximately, and the situation of surgical operation perioperative systematic antibiotics is then up to 95%.In inpatient, the antibiotic utility ratio is 79%, and this numeral is higher than 22% and various countries' average level 30% of Britain far away.Simultaneously, because the doctor abuses broad-spectrum antiseptic class medicines such as ampicillin, cause dysbacteriosis in the human body and bring out the situation of superinfection of common occurrence especially.
Even to this day, the fastbacteria problem of China has become very outstanding, and the microbial nosocomial infection number of drug resistance has accounted for about 30% of HOI patient total number of persons, and unfortunately, the invention of new antibiotic can't be caught up with the step of resistance.Mostly the serious symptom pyaemia septica is growth and breeding in these type of drug resistance pathogenic bacterium or the conditioned pathogen intrusion blood circulation, produce toxin and the caused acute systemic infection of other metabolites, be feature with shiver with cold, hyperpyrexia, erythra, arthralgia and hepatosplenomegaly clinically, part can have septic shock and migrate the sexually transmitted disease (STD) kitchen range.The appearance of fastbacteria has increased the difficulty that infectious disease is cured, and forces the human method that new combating microorganisms infects of seeking.
Summary of the invention
The invention provides non-medicine fastbacteria pyaemia septica therapy system, adopt this non-medicine fastbacteria pyaemia septica therapy system to handle, the pathogenic bacteria of drug-resistant that exists in the blood plasma directly can be killed, reach the purpose of disease-resistant former treatment.And with low cost, that any chemicals is not added in the deactivation of HHP cause of disease is safe and effective, cause of disease deactivation spectrum is wide, with low cost, safe and effective, simple in structure, easy to operate, and is good with the existing equipment compatibility, the suitable popularization.
The technical solution used in the present invention is: non-medicine fastbacteria pyaemia septica therapy system, non-medicine fastbacteria pyaemia septica therapy system, its formation comprises the sampled plasma machine, disposable machine-collected plasma bacterial isolate deactivation multipurpose processor, HHP blood plasma cause of disease deactivation instrument, wherein disposable machine-collected plasma bacterial isolate deactivation multipurpose processor comprises hemostix, pipeline, the separating plasma cup, tubular plasma collection supertension inactivation treatment bag, lengthening blood plasma pipeline, the puncture medicated cap, flow-stopping clip, blood filter, pressure monitor, saline feeds back pin and helmet, anticoagulant and helmet, it is characterized in that: hemostix connects threeway after flow-stopping clip is set, feed back pin and helmet and anticoagulant and helmet with saline again the pipeline of flow-stopping clip after in parallel is set, blood filter connects, blood filter connects pressure monitor, and connect with the separating plasma cup by pipeline, the separating plasma cup connects after the threeway and tubular plasma collection supertension inactivation treatment bag by lengthening blood plasma pipeline, on the tubular plasma collection supertension inactivation treatment bag puncture medicated cap is set.
The application of non-medicine fastbacteria pyaemia septica therapy system of the present invention, above-mentioned disposable machine-collected plasma bacterial isolate deactivation multipurpose processor blood is installed in the sampled plasma machine, blood injects a certain proportion of anticoagulant by hemostix flow ipe after the human body collection by anticoagulant and helmet; This moment, saline fed back pin and helmet closedown of pipeline, the blood that injects certain anticoagulant flows into the separating plasma cup by blood filter, enter tubular plasma collection supertension inactivation treatment bag by the effusive blood plasma of separating plasma cup, capacity can be at 200ml-800ml, after blood flows into tubular plasma collection supertension inactivation treatment bag by pipeline, the cut-out pipeline is carried out and is fused after reaching quantitative blood plasma, tubular plasma collection supertension inactivation treatment bag is put into HHP blood plasma cause of disease deactivation instrument carry out the cause of disease deactivation, blood plasma in the tubular plasma collection supertension inactivation treatment bag after the deactivation can feed back pin by saline and feed back human body, reaches therapeutic purposes.
Tubular plasma collection supertension inactivation treatment bag is high pressure inactivating device (blood plasma pressurized under 5 ℃～15 ℃, 250～350MPa condition being handled 5～10 minutes pressurization pressure release circulation 1-3 time), treats to feed back to human body by saline feedback pin after the deactivation.
The present invention has obtained following beneficial effect: adopt non-medicine fastbacteria pyaemia septica therapy system, with low cost, do not add any chemicals, it is wide, with low cost, safe and effective that pathogen is killed spectrum, simple in structure, easy to operate, good with the existing equipment compatibility, the suitable popularization.In addition, the sampled plasma machine and the HHP blood plasma cause of disease deactivation instrument of prior art can be realized the deactivation of supertension cause of disease with processor and the combination of fitting operation program chains that the inventor designs, the pathogenic bacteria of drug-resistant that exists in the blood plasma is directly effectively killed.Discontinuous blood plasma feeds back and handles after the deactivation, reaches the purpose of treatment.
Description of drawings
Fig. 1 is a blood separation device structure sketch map, wherein.
The 1-hemostix, 2-pipeline, 3-separating plasma cup, 4-tubular plasma collection supertension inactivation treatment bag, 5-lengthening blood plasma pipeline, 6-flow-stopping clip I, 7-flow-stopping clip II, the 8-medicated cap that punctures, 9-flow-stopping clip III, 10-blood filter, 11-pressure monitor, 12-saline feeds back pin and helmet, 13-anticoagulant and helmet.
The specific embodiment
Below in conjunction with accompanying drawing the present invention is done a detailed description:
The technical solution used in the present invention is: non-medicine fastbacteria pyaemia septica therapy system, its formation comprises the sampled plasma machine, disposable machine-collected plasma bacterial isolate deactivation multipurpose processor, HHP blood plasma cause of disease deactivation instrument, wherein disposable machine-collected plasma bacterial isolate deactivation multipurpose processor comprises hemostix, pipeline, the separating plasma cup, tubular plasma collection supertension inactivation treatment bag, lengthening blood plasma pipeline, the puncture medicated cap, flow-stopping clip, blood filter, pressure monitor, saline feeds back pin and helmet, anticoagulant and helmet, it is characterized in that: hemostix connects threeway after flow-stopping clip is set, feed back pin and helmet and anticoagulant and helmet with saline again the pipeline of flow-stopping clip after in parallel is set, blood filter connects, and blood filter connects pressure monitor, and connects with the separating plasma cup by pipeline, the separating plasma cup connects after the threeway and tubular plasma collection supertension inactivation treatment bag by lengthening blood plasma pipeline, on the tubular plasma collection supertension inactivation treatment bag puncture medicated cap is set.
The application of non-medicine fastbacteria pyaemia septica therapy system of the present invention, be that above-mentioned disposable machine-collected plasma bacterial isolate deactivation multipurpose processor blood is installed in the sampled plasma machine, blood injects a certain proportion of anticoagulant by hemostix flow ipe after the human body collection by anticoagulant and helmet; This moment, saline fed back pin and helmet closedown of pipeline, the blood that injects certain anticoagulant flows into the separating plasma cup by blood filter, enter tubular plasma collection supertension inactivation treatment bag by the effusive blood plasma of separating plasma cup, capacity can be at 200ml-800ml, after blood flows into tubular plasma collection supertension inactivation treatment bag by pipeline, the cut-out pipeline is carried out and is fused after reaching quantitative blood plasma, tubular plasma collection supertension inactivation treatment bag is put into HHP blood plasma cause of disease deactivation instrument carry out the cause of disease deactivation, blood plasma in the tubular plasma collection supertension inactivation treatment bag after the deactivation can feed back pin by saline and feed back human body, reaches therapeutic purposes.
Tubular plasma collection supertension inactivation treatment bag is high pressure inactivating device (blood plasma pressurized under 5 ℃～15 ℃, 250～350MPa condition being handled 5～10 minutes pressurization pressure release circulation 1-3 time), treats to feed back to human body by saline feedback pin after the deactivation.
Performance test: by use under 5 ℃～15 ℃, 250～350MPa condition, the method for cycle-index (1-2 time), evidence pathogen such as drug resistance staphylococcus epidermidis can be killed, and the normal composition of blood plasma does not have obvious influence.
Claims (4)
1. non-medicine fastbacteria pyaemia septica therapy system, its formation comprises: the sampled plasma machine, disposable machine-collected plasma bacterial isolate deactivation multipurpose processor, HHP blood plasma cause of disease deactivation instrument, wherein disposable machine-collected plasma bacterial isolate deactivation multipurpose processor comprises: hemostix, pipeline, the separating plasma cup, tubular plasma collection supertension inactivation treatment bag, lengthening blood plasma pipeline, the puncture medicated cap, flow-stopping clip, blood filter, pressure monitor, saline feeds back pin and helmet, anticoagulant and helmet, it is characterized in that: hemostix connects threeway after flow-stopping clip is set, and feeds back pin and helmet and anticoagulant and helmet with saline again the pipeline of flow-stopping clip after in parallel is set, blood filter connects, and blood filter connects pressure monitor, and be connected with the separating plasma cup by pipeline, the separating plasma cup is connected with tubular plasma collection supertension inactivation treatment bag after connecting threeway by lengthening blood plasma pipeline, on the tubular plasma collection supertension inactivation treatment bag puncture medicated cap is set, and the puncture medicated cap is used as feeding back puncture.
2. according to the application of the described non-medicine fastbacteria pyaemia septica therapy system of claim 1, it is characterized in that: disposable machine-collected plasma bacterial isolate deactivation multipurpose processor is installed in the sampled plasma machine, start plasma collection procedure, blood injects a certain proportion of anticoagulant by hemostix flow ipe after the human body collection by anticoagulant and helmet; This moment, saline fed back pin and helmet closedown of pipeline, the blood that injects certain anticoagulant flows into the separating plasma cup by blood filter, enter tubular plasma collection supertension inactivation treatment bag by the effusive blood plasma of separating plasma cup, capacity can be at 200ml-800ml, after blood plasma flows into tubular plasma collection supertension inactivation treatment bag by pipeline, the cut-out pipeline is carried out and is fused after reaching quantitative blood plasma, tubular plasma collection supertension inactivation treatment bag is put into HHP blood plasma cause of disease deactivation instrument carry out the cause of disease deactivation, can feed back pin by saline after the blood plasma process HHP blood plasma cause of disease deactivation instrument deactivation in the tubular plasma collection supertension inactivation treatment bag and feed back patient, reach therapeutic purposes.
3. according to the application of claim 1 or 2 described non-medicine fastbacteria pyaemia septica therapy system, it is characterized in that: blood plasma is closed tubular plasma collection supertension inactivation treatment bag after the collection of tubular plasma collection supertension inactivation treatment bag finishes, carry out and fuse, carry out deactivation, by that analogy, carry out successively feeding back pin feedback human body by saline after the deactivation, can carry out sequential processing according to the several plasma treatment bags of the many interpolations of patient's situation.
4. according to the application of claim 1 or 2 described non-medicine fastbacteria pyaemia septica therapy system, it is characterized in that: tubular plasma collection supertension inactivation treatment bag is put into HHP blood plasma cause of disease deactivation instrument, blood plasma is under 5 ℃～15 ℃, 250～350MPa condition after pressurized treatments 5-10 minute, pressure release is made zero, pressurization pressure release circulation 1-3 time, the pathogen that may exist in the blood plasma is killed, blood plasma after will sterilizing then feeds back to human body, reaches the therapeutic purposes that alleviate pathogen load in the blood circulation.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201110197184.1A CN102284094B (en) | 2011-07-14 | 2011-07-14 | Non-drug therapy system for septicopyemia caused by drug-resistance bacteria |
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| CN201110197184.1A CN102284094B (en) | 2011-07-14 | 2011-07-14 | Non-drug therapy system for septicopyemia caused by drug-resistance bacteria |
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| CN102284094A true CN102284094A (en) | 2011-12-21 |
| CN102284094B CN102284094B (en) | 2014-03-12 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104174042A (en) * | 2014-08-29 | 2014-12-03 | 郑州飞龙医疗设备有限公司 | Ultrahigh-pressure inactivating method for pathogens in biological products and applications thereof |
| CN105854039A (en) * | 2016-05-21 | 2016-08-17 | 郑州飞龙医疗设备有限公司 | Ultrahigh pressure inactivation method and equipment for pathogens in liquid biological products |
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| CN2393550Y (en) * | 1999-09-09 | 2000-08-30 | 浙江博朗生物工程有限公司 | Automatic blood separator |
| CN2443725Y (en) * | 2000-11-06 | 2001-08-22 | 张明礼 | Blood treating curing machine |
| CN1404883A (en) * | 2001-08-10 | 2003-03-26 | 可乐丽股份有限公司 | Blood treatment apparatus |
| CN101534877A (en) * | 2006-11-08 | 2009-09-16 | 美国血液技术公司 | Adaptable perioperative cell-salvage system and methods and disposable units for same |
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2011
- 2011-07-14 CN CN201110197184.1A patent/CN102284094B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2393550Y (en) * | 1999-09-09 | 2000-08-30 | 浙江博朗生物工程有限公司 | Automatic blood separator |
| CN2443725Y (en) * | 2000-11-06 | 2001-08-22 | 张明礼 | Blood treating curing machine |
| CN1404883A (en) * | 2001-08-10 | 2003-03-26 | 可乐丽股份有限公司 | Blood treatment apparatus |
| CN101534877A (en) * | 2006-11-08 | 2009-09-16 | 美国血液技术公司 | Adaptable perioperative cell-salvage system and methods and disposable units for same |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104174042A (en) * | 2014-08-29 | 2014-12-03 | 郑州飞龙医疗设备有限公司 | Ultrahigh-pressure inactivating method for pathogens in biological products and applications thereof |
| CN105854039A (en) * | 2016-05-21 | 2016-08-17 | 郑州飞龙医疗设备有限公司 | Ultrahigh pressure inactivation method and equipment for pathogens in liquid biological products |
| CN105854039B (en) * | 2016-05-21 | 2019-01-25 | 郑州飞龙医疗设备有限公司 | To the super-pressure ablation method and equipment of pathogen in liquid bio product |
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| Publication number | Publication date |
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| CN102284094B (en) | 2014-03-12 |
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