CN101816678A - Broad-spectrum contact type hemostatic medical fungicide and preparation method thereof - Google Patents
Broad-spectrum contact type hemostatic medical fungicide and preparation method thereof Download PDFInfo
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- CN101816678A CN101816678A CN201010149420A CN201010149420A CN101816678A CN 101816678 A CN101816678 A CN 101816678A CN 201010149420 A CN201010149420 A CN 201010149420A CN 201010149420 A CN201010149420 A CN 201010149420A CN 101816678 A CN101816678 A CN 101816678A
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Abstract
The invention discloses a broad-spectrum contact type hemostatic medical fungicide and a preparation method thereof. The fungicide comprises the following components in percentage by weight: 5 to 15 percent of povidone iodine, 3 to 10 percent of chitosan, 3 to 10 percent of petroleum jelly for medical purposes, 1 to 5 percent of nonoxinol, and the balance of purified water. After the fungicide is contacted with a wound surface or an affected part, the fungicide can depolymerize and release the contained iodine to achieve the function of sterilization. The product is the broad-spectrum powerful disinfectant, has strong killing effect on viruses, bacteria, fungi and mycoticspore, not only has long constant acting time, but also has small irritation to human skin, greatly reduces pains unbearable for ordinary people, and simultaneously has the function of hemostasis. The fungicide is applicable to skin and mucousmembrane infection, can be directly used for disinfecting graze, and is safe and convenient to use.
Description
[technical field]
The present invention relates to a kind of medical disinfection sanitizer, relate in particular to a kind of skin surface, a kind of disinfection solution of wound sterilizing of being used for.
[background technology]
At present, in medical treatment clinical course, 3% concentration hydrogen peroxide, 70% concentration ethanol and iodine tincture are arranged for the skin degerming cleaning liquid of sterilizing usually, wherein iodine tincture it be the liquid that iodine is dissolved in institute's shape among the alcoholic solution of potassium iodide.Concrete using method is to dip bottled above-mentioned sterilization cleaning liquid with the cotton rod of common plastics, articles for use such as skin degerming, operation and wound, injection and site of puncture sterilization, oral disinfecting, vagina sterilization, vessel is carried out disinfection again.In daily use,, will cause cross infection if improper use is put into sterilization cleaning liquid bottle once more with used cotton rod.The disinfective action of these conventional sterilization disinfectant not only the persistent period not long, and the strain that can kill is limited, simultaneously, this class sterilization is big to tissue irritation, with clean wound, skin ulceration place, mucosa infection place, can produce the pain and the damage of stimulation to the patient, patient be caused the misery that is difficult to bear.Simultaneously, it can not infiltrate deep skin effectively, more can not stop blooding.
Along with the development of society, the raising of people's health care consciousness, people improve constantly the requirement of external disinfectant, and people extremely thirst for broad-spectrum contact type hemostatic medical sterilization iodine coagulant liquid.
[summary of the invention]
The purpose of this invention is to provide a kind of broad-spectrum contact type hemostatic medical fungicide and preparation method thereof, it not only has the broad-spectrum disinfection function, virus, antibacterial, fungus and mycotic spore all there is stronger killing action, and it is little to skin irritation, no pain almost when the patient uses, toxicity is low, and the continuous action time is long, and is safe in utilization, easy.
Described broad-spectrum contact type hemostatic medical fungicide comprises following component, povidone iodine; Chitosan; Medical ventolin; Nonoxynolum and pure water, the weight percentage of each component is: povidone iodine 5%～15%; Chitosan 3%～10%; Medical ventolin 3%～10%; Nonoxynolum 1%～5%; All the other are pure water.
Embodiment 1, the weight content of each component is: povidone iodine 10%; Chitosan 8%; Medical ventolin 5%; Nonoxynolum 2.5%; Pure water 74.5%.
Embodiment 2, the weight content of each component is: povidone iodine 5%; Chitosan 3%; Medical ventolin 3%; Nonoxynolum 1%; Pure water 89%.
Embodiment 3, the weight content of each component is: povidone iodine 15%; Chitosan 10%; Medical ventolin 10%; Nonoxynolum 5%; Pure water 60%.
In component of the present invention, povidone iodine claims povidone iodine, Iodophors again, it is recorded the sterile products into American Pharmacopeia, British Pharmacopoeia, Japanese Pharmacopoeia and the Pharmacopoeia of the People's Republic of China present unique while, taken in the national essential drugs catalogue, and gone through the disinfectant that can be used on health care, the direct use of human body in 9 years again.It is generally acknowledge in the world efficient, wide spectrum, and nontoxic antibacterial, it has extremely strong sterilizing power and fungicidal spectrum widely.It all has stronger killing action to staphylococcus aureus, gonococcus, bacillus pyocyaneus, treponema pallidum, hepatitis B virus, HIV (human immunodeficiency virus), trichomonas vaginitis, spore etc., in the in vitro tests that common clinically antibacterial is carried out, almost there is not a kind of antibacterial not to be killed.
Poly-chitose is a kind of natural polymer sulfated polysaccharide ester polymer, wherein contains dissimilar sulfated polysaccharide esters, and they all have the quick-acting haemostatic powder function.
Nonoxynolum is a kind of surface activity medicine, has the spermicide function, and this material is commercial product.
Medical ventolin is a kind of commercial commodity.
The present invention detects through U.S.'s antibacterial test laboratory, it all has stronger killing action to have biocidal efficacies to 25 kinds of antibacterials, virus, fungus, mycete, spore etc., meet U.S. FDA GLP standard, compared with common medicine antibacterial such as ethanol, its bactericidal effect is quicker, more efficient, be embodied in clinical operation especially before, use in the sterilization pretreatment of doctors and patients wound, have characteristics such as low toxicity, efficient, slow release, can guarantee working long hours of medical operating.For traditional sterile products, povidone iodine is gentle more, and range of application is more extensive.70% the medicinal alcohol wound of can directly sterilizing, but it stimulates the pain and the damage ordinary person that are produced to be difficult to bear, and iodine tincture can discharge iodine equally and sterilize, but because the strong oxidizing property of iodine, often skin and medicated clothing are produced very strong corrosivity, be difficult to clean in case be infected with.And the povidone iodine product is discharging the germ-resistant while of elemental iodine, and skin, mucosa etc. are not stimulated, and release time is long simultaneously, effect is lasting, because the chemical characteristic of povidone iodine makes its easier cleaning when being infected with skin and medicated clothing, for user has solved a lot of unnecessary worries.
After the present invention contacts wound surface or affected part, can depolymerization discharge contained iodine, thereby performance bactericidal action, be characterized in little to tissue irritation, be applicable to skin, mucosa infection, it stimulates pain and the damage that is produced, and contrasts other common drug antibacterial, alleviated the misery that ordinary person is difficult to bear greatly, the scratch of can directly sterilizing.This product is the broad-spectrum powerful disinfectant, and virus, antibacterial, fungus and mycotic spore are all had stronger killing action.This product is little to skin irritation, and toxicity is low, and effect is lasting, and is safe in utilization, easy.To organizing basic nonirritant, be used for the sterilization of skin and mucosa, as perform the operation preceding cleaning, operative site and wound disinfection etc.
In the present invention, povidone iodine, poly-two kinds of components of chitose can carry out composite synergistic, cooperate sterilization in different sterilization fields; The function that vaseline has the protection skin wet, pins skin moisture makes the present invention within rational humidity scope, slowly releases iodine and brings into play bactericidal action; The present invention is little to tissue stimulation.Utilize natural poly-chitose, it is the unique positively charged natural bactericidal agent of occurring in nature, is used the Synergistic sterilizing effect of playing with povidone iodine, also has hemostasia effect.
When the present invention is used for production dosing external sterilizing sterilization cleaning cotton swab, wound and applies pad, the band series of high efficiency that stretches tight and sterilize serial medical science casting product, need not product carried out conventional sterilization treatment such as R ray, ETO oxirane, electron beam, as long as adopt the dry heat sterilization mode, the advantage that sterilising prods is in rapidly and efficiently all the time, the persistent period is permanent has been guaranteed in the bactericidal action of the povidone iodine gel solution available iodine self under high temperature action by wherein.The use of this sterilization method has overcome in other sterilization methods that sterilization time is long, sterilized pharmaceutics is deposited defective loaded down with trivial details in parsing, the sterilization process.
The preparation method of broad-spectrum contact type hemostatic medical fungicide of the present invention is as follows:
The first step is pressed the weight percentage of each component and is purchased the each component raw material;
Second step, drop into medical ventolin in the reactor and be warming up to vaseline earlier and all melt, start the high shear machine then, slowly drip nonoxynolum by ratio requirement, nonoxynolum and vaseline will be emulsified into the microemulsion of band blue streak, be cooled to 50 ℃ then;
In the 3rd step, in another homogenizing still of microemulsion suction of the band blue streak that second step was obtained, drop into povidone iodine, poly-chitose and pure water by ratio requirement then and carry out homogenizing and handled 4～12 hours;
The 4th step, with the 3rd solution left standstill of step behind the homogenizing 5～10 hours, finished fluid.
[specific embodiment]
Embodiment 1: described broad-spectrum contact type hemostatic medical fungicide, and it is formulated by povidone iodine, chitosan, medical ventolin, nonoxynolum and pure water, and the weight percentage of each component is a povidone iodine 10%; Chitosan 8%; Medical ventolin 5%; Nonoxynolum 2.5%; Pure water 74.5%.
Its preparation method is as follows:
The first step is pressed the weight percentage of each component and is purchased the each component raw material;
Second step, drop into vaseline in the reactor and be warming up to vaseline and all melt, start the high shear machine then, slowly drip nonoxynolum by ratio requirement, make both be emulsified into the microemulsion of band blue streak, be cooled to 50 ℃ then;
In the 3rd step, in another homogenizing still of microemulsion suction of the band blue streak that second step was obtained, drop into povidone iodine, poly-chitose and pure water by ratio requirement then and carry out homogenizing and handled 12 hours;
The 4th step, with the 3rd solution left standstill of step behind the homogenizing 6 hours, finished fluid.
Embodiment 2, and the weight content of each component is: povidone iodine 5%; Chitosan 3%; Medical ventolin 3%; Nonoxynolum 1%; Pure water 89%.
Embodiment 3, and the weight content of each component is: povidone iodine 15%; Chitosan 10%; Medical ventolin 10%; Nonoxynolum 5%; Pure water 60%.
Embodiment 2 is all identical with embodiment 1 with the preparation method of implementing 3.
Claims (5)
1. broad-spectrum contact type hemostatic medical fungicide, it is characterized in that: it comprises following component, povidone iodine; Chitosan; Medical ventolin; Emulsifying agent and pure water, the weight percentage of each component is: povidone iodine 5%～15%; Chitosan 3%～10%; Medical ventolin 3%～10%; Nonoxynolum 1%～5%; All the other are pure water.
2. according to the described broad-spectrum contact type hemostatic medical fungicide of claim 1, it is characterized in that: the weight content of each component is: povidone iodine 10%; Chitosan 8%; Medical ventolin 5%; Nonoxynolum 2.5%; Pure water 74.5%.
3. according to the described broad-spectrum contact type hemostatic medical fungicide of claim 1, it is characterized in that: the weight content of each component is: povidone iodine 5%; Chitosan 3%; Medical ventolin 3%; Nonoxynolum 1%; Pure water 89%.
4. according to the described broad-spectrum contact type hemostatic medical fungicide of claim 1, it is characterized in that: the weight content of each component is: povidone iodine 15%; Chitosan 10%; Medical ventolin 10%; Nonoxynolum 5%; Pure water 60%.
5. as the preparation method of broad-spectrum contact type hemostatic medical fungicide as described in claim 1 or 2 or 3 or 4, comprise the steps:
The first step is pressed the weight percentage of each component and is purchased the each component raw material;
Second step, drop into vaseline in the reactor and be warming up to vaseline earlier and all melt, start the high shear machine then, ratio requirement slowly drips emulsion, makes it be emulsified into the microemulsion of band blue streak, is cooled to 50 ℃ then;
In the 3rd step, in another homogenizing still of microemulsion suction of the band blue streak that second step was obtained, drop into povidone iodine, poly-chitose and pure water by ratio requirement then and carry out homogenizing and handled 4～8 hours;
The 4th step was with the 3rd solution left standstill of step behind the homogenizing 5～10 hours.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201010149420A CN101816678A (en) | 2010-04-19 | 2010-04-19 | Broad-spectrum contact type hemostatic medical fungicide and preparation method thereof |
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| CN201010149420A CN101816678A (en) | 2010-04-19 | 2010-04-19 | Broad-spectrum contact type hemostatic medical fungicide and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103202854A (en) * | 2013-04-06 | 2013-07-17 | 江苏健裕健康医疗器械有限公司 | Povidone iodine compound disinfectant |
| CN103432160A (en) * | 2013-08-16 | 2013-12-11 | 江苏省健尔康医用敷料有限公司 | Broad spectrum contact type medical surgical lavage fluid and preparation method thereof |
| CN112206322A (en) * | 2020-11-13 | 2021-01-12 | 深圳先进技术研究院 | Bactericide and preparation method and application thereof |
| WO2022119322A1 (en) * | 2020-12-04 | 2022-06-09 | 단국대학교 천안캠퍼스 산학협력단 | Hemostatic composition comprising novel compound |
-
2010
- 2010-04-19 CN CN201010149420A patent/CN101816678A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103202854A (en) * | 2013-04-06 | 2013-07-17 | 江苏健裕健康医疗器械有限公司 | Povidone iodine compound disinfectant |
| CN103202854B (en) * | 2013-04-06 | 2015-08-19 | 江苏健裕健康医疗器械有限公司 | Poly-dimension cave iodine compound recipe disinfection sanitizer |
| CN103432160A (en) * | 2013-08-16 | 2013-12-11 | 江苏省健尔康医用敷料有限公司 | Broad spectrum contact type medical surgical lavage fluid and preparation method thereof |
| CN112206322A (en) * | 2020-11-13 | 2021-01-12 | 深圳先进技术研究院 | Bactericide and preparation method and application thereof |
| WO2022119322A1 (en) * | 2020-12-04 | 2022-06-09 | 단국대학교 천안캠퍼스 산학협력단 | Hemostatic composition comprising novel compound |
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Application publication date: 20100901 |