CN101327225A - Bee honey acid composition and preparation method and uses thereof - Google Patents
Bee honey acid composition and preparation method and uses thereof Download PDFInfo
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Abstract
The invention relates to a preparation method of honey acid mixture and an application of the honey acid mixture in preventing and/or curing diseases. The raw materials of the honey acid mixture includes ethanol with a temperature ranging from 15 DEG C to 45 DEG C, honey and edible additive hydrochloric acid containing over 31 percent of HCI, which are prepared with the addition of water. The volume ratio of the ethanol, the honey, the edible additive hydrochloric acid and the water is 1 to 10: 1 to 70: 1 to 9: 1 to 97. the honey acid mixture prepared by the invention can prevent and/or cure intestine and stomach illnesses, lithiasis, prostate diseases and diabetes; the curative effect is good and the performance is safe and reliable.
Description
Technical field
The present invention relates to pharmacy, relate in particular to a kind of acidic composition and preparation method and application thereof, be used to prevent and/or treat intestinal, gastropathy, calculus, prostatosis, diabetes.
Background technology
Intestinal, gastropathy are human commonly encountered diseases, frequently-occurring disease, change along with growth in the living standard and dietary structure, increasing people is perplexed by intestinal, gastropathy, age is big more, and sickness rate is high more, and particularly the middle-aged and elderly people more than 50 years old more more sees, the male is higher than the women, as untimely treatment, the prolonged and repeated outbreak of meeting also easily is converted into cancerous protuberance.At present the intestinal of various big hospital clinic, patients with gastric disease are growing on and on, and continuous rejuvenation trend is arranged.Its pathogeny is comparatively complicated, does not illustrate fully as yet so far, currently prevents and/or treats, the types of drugs of intestinal, gastropathy is various, and common drug all is medication improvement, end-of-dose failure, forms vicious cycle, obstinate.Secular intestinal, gastropathy also cause multiple complications easily.And chronic colitis, proctitis, constipation, gastric ulcer, gastric perforation stay repent forever to the patient.So intestinal, gastropathy always are considered as the disease of difficulty by medical circle, be the difficult problem that medical circle is paid close attention to always.
Calculus also is a kind of stubborn disease, and the symptom complexity is easy to residual.Medically also do not do bright its reason, the Health and Living quality that is seriously threatening people at present fully.
Prostatosis is the middle-aging male common disease, the male had hypertrophy in various degree later on from 35 years old, clinical symptoms appearred later in 50 years old, primary disease is along with growth in the living standard, sickness rate raises year by year, because outgrowth prostate can be oppressed urethra, causes that promptly patient's nocturia increases, symptoms such as frequent micturition, dysuria, urine retention.Its pathogeny is not clear and definite as yet so far, and opinions vary for the scholar of each side, had a strong impact on male patient's life quality.At present the types of drugs of treatment prostatosis is a lot, all be take a turn for the better the time spent, end-of-dose failure, form vicious cycle, obstinate also with in various degree side effect, brings very big worry to the patient.
Diabetes are a kind of whole body slow-motion row metabolic diseases, and clinical manifestation is blood sugar increasing, the glucose in urine positive, carbohydrate tolerance reduction.Classical symptom is a three-many-one-little, promptly many meals, polyphagia, polyuria and lose weight.Easy concurrent whole body nerve, blood capillary, macroangiopathy, and can cause the chronic progressive external pathological changes of the heart, brain, kidney, nerve and ocular tissue's organ.Be very thorny difficult problem of medical circle, its pathogenic factor is also not too clear so far, can only control, but can not cure.Though the medicine of control of diabetes is a lot of on the market, clothes have such and such side effect more for a long time, bring psychological burden to the patient.
Summary of the invention
In order to solve the variety of issue that above-mentioned disease and medicine exist, the invention provides a kind of bee honey acid composition and preparation method thereof and preventing and/or treating intestinal, gastropathy, calculus, prostatosis and diabetes.
The invention discloses a kind of bee honey acid composition, mainly is to be prepared from by following raw materials according: 15-45 ℃ of ethanol, Mel, 〉=31% edible additive hydrochloric acid, water; Its volume ratio is 1-10: 1-70: 1-9: 1-97.
Preferably, described bee honey acid composition volume ratio is 5-10: 10-30: 3-8: 62-82.
Described ethanol is wine or the edible ethanol of alcoholic strength at the 15-45 degree; Described Mel is commercially available high-quality Mel; Described edible additive hydrochloric acid is the edible additive hydrochloric acid of 〉=31% concentration/or reagent hydrochloric acid solution of 36.46; Described water is the boiled water that burns till of tap water or mineral water, ignorant water purification.
Described bee honey acid composition prevents and/or treats application in intestinal, gastropathy, calculus, prostatosis, the diabetes medicament in preparation.
Described bee honey acid composition also comprise with one or more prevent and/or treat, intestinal, gastropathy, calculus, prostatosis, treatment of diabetes medicine, the same usefulness of agent, to heighten the effect of a treatment or to play synergism.
Described bee honey acid composition is oral liquid formulation or injection dosage form, tablet, capsule, but is not limited thereto.
Described bee honey acid composition also can be applied in any solution, prevents and/or treats, intestinal, gastropathy, calculus, prostatosis, diabetes, but is not limited thereto.
Described bee honey acid composition is characterized in that, described bee honey acid composition adds water 1-100 and doubly dilutes and drink, and prevents and/or treats intestinal, gastropathy, calculus, prostatosis, diabetes, but is not limited thereto.
The invention also discloses a kind of preparation method of bee honey acid composition, comprise the steps:
After step 103. cooling, add Mel, edible additive hydrochloric acid solution, heat to 20-30 ℃ restir 15 minutes;
It is canned, bottled etc. that bee honey acid composition after standby can carry out, and perhaps purifies and make various medicals.
The present invention is as follows to the formation mechanism and the effect of intestinal, gastropathy, calculus, prostatosis, diabetes:
The mechanism of production of intestinal tract disease is: because the variation of ingesta structure and the influence of toxin, change has taken place in the slant acidity environment in the human body intestinal canal, makes alteration of intestinal flora, and the poisonous bacterial infection that causes a disease causes.Have hundreds of different bacterium perching in the human body intestinal canal approximately, pathogenic bacterium are harmful, and non-pathogenic bacteria is then favourable to human body, and both are keeping certain balance, make intestinal that disease not take place.Most importantly bacillus bifidus in the probiotics, during the baby, 99% is bacillus bifidus in the intestinal bacterium, because bacillus bifidus can be made acetic acid and lactic acid, so the pH value slant acidity of enteral can suppress the breeding of pathogen, prevents that intestinal is infected.During to the child, bacillus bifidus is reduced to 10%, and with the growth at age, the variation of slant acidity environment reduces the quantity of non-pathogenic bacteria gradually in the intestinal, and by 60 years old, bacillus bifidus only was left 1%.Therefore alteration of intestinal flora, pathogenic bacterium are taken advantage of a weak point, and cause a large amount of breedings, invasion and attack intestinal and cause the generation of intestinal tract disease.Because intestinal slant acidity environment change, according to the slant acidity environment, different intestinal tract diseases just takes place, as chronic colitis, ulcerative colitis, duodenal ulcer, perforation, constipation or the like in the time of change and numerical value different.
The Therapeutic Method of intestinal tract disease: based on above-mentioned mechanism, through research practice, prepared bee honey acid composition, be to make by organic acid and mineral acid, bigger than gastric acid (gastric acid only is organic acid) in the intravital effect of people, stronger sterilization, detoxifcation, antiinflammatory, decomposition, the effect of mediation intestinal are arranged, and it can kill suppurative staphylococcus, salmonella, escherichia coli, dysentery bacterium, bite pathogenic bacteria and viruses such as salt bacterium.Thereby the purification intestinal, balance function of intestinal canal, diseases such as the diarrhoea that elimination enteritis, duodenal ulcer cause, constipation.Decompose the toxin and the food debris of alluvial in the intestinal, keep the slant acidity environment that originally has in the human body intestinal canal, improve the intestinal microcirculation, correct dysbacteriosis, suppress poisonous germ reproduction, prevent that intestinal is infected.Promote tissue regeneration, the intestinal granulation promoting that heals to repair intestinal mucosa.Have an effect with glycoprotein in the casing slime, form insoluble protecting film, the recurrence of prevention intestinal tract disease, thus recover the intestinal normal physiological function, reach the purpose of curing intestinal tract disease.
The mechanism of production of gastropathy is: the gastric sour environment changes, cause gastric acid obviously to reduce or shortage, cause the gastric dysbacteriosis, after gastric mucosa is subjected to the infection of pathogenic bacterium, after gastric mucosa surface sustains damage repeatedly, infected by microbes or bacteriotoxin, deposit at gastric, neuroendocrine function disorder, gastric peristalsis vigor deficiency, obstacle, mucosa ischemic necrosis take place in the circulation of blood fortune, the regeneration of cell is upgraded and is not caught up with, cause the intrinsic body of gland atrophy of mucosa, the mucous layer attenuation, muscular layer of mucosa is common to be thickened and atypical hyperplasia etc.Involve the mucous layer of stomach and the generation that flesh layer, pylorus functional disorder, bile and intestinal juice had backflowed, caused gastropathy.Symptoms such as chronic superficial gastritis, chronic superficial atrophic gastritis and atrophic gastritis appear.Lecithin in cholate in the bile, bicarbonate and the 12 finger liquid, the quick class of Trypsin etc., if honestly staying in the duodenum all is the requisite person who has rendered outstanding service of digestion, but in case the gastric that backflows has just become the out and out saboteur of a group.Thereby their infringement gastric mucosas cause inflammation, and are called bile reflux gastritis clinically.And the liquid that backflows is alkalescence, so have another name called alkaline reflux gastritis.
The Therapeutic Method of gastropathy: based on above-mentioned mechanism; through research practice, prepared bee honey acid composition is to be made by organic acid and mineral acid; organic acid plays replenishing gastric acid, collaborative gastric acid protection mucosa, blood vessel, organ pipe wall, repairs organ pipe damage, the effect that improves immunity.Mineral acid has the effect of stronger sterilization, detoxifcation, antiinflammatory, decomposition, fat melting, raising metabolism function, harmonizing intestine-stomach.Can kill the pathogenic bacteria and the virus of gastric, kill the antibacterial that enters gastric with food, thus significant to keeping the enteral aseptic condition of harmonization of the stomach, activate pepsinogen, make it to change into activated pepsin, and the sour environment of necessity is provided for the pepsin effect.After entering small intestinal, can cause the release of secretin, thereby promote the secretion of pancreatic juice, bile and intestinal fluid.The sour environment that hydrochloric acid caused also helps the absorption of small intestinal to ferrum and calcium.Decompose the toxin and the food debris of gastric alluvial, suppress the breeding of poisonous pathogenic bacteria, suppress the gastric corruption, prevent that stomach is infected, correct dysbacteriosis and eliminate gastritis.Keep the slant acidity environment value that gastric originally has; (when the doctor is everlasting patient's achlorhydria; give 1% dilute hydrochloric acid to gastric acid deficiency or anacidity person); microcirculation improvement, backflowing property of neutralization alkali liquor, raising gastric motility; promote the metabolism of tissue regeneration and flesh confluent monolayer cells, the stomach granulation promoting that heals to repair gastric mucosa; improve the function of gastric gland secretion and Digestive system; have an effect with glycoprotein in the gastric mucus; form insoluble protecting film; the recurrence of prevention gastropathy; thereby recover the stomach normal physiological function, reach the purpose of treatment gastropathy.
The mechanism of production of various calculus diseases is: the calculus of indication has (cholelithiasis, calculus of intrahepatic duct, renal calculus, ureteral calculus, vesical calculus, broncholithiasis, pancreatic stone, calculus of prostate, appendicular lithiasis etc.).1, human body slant acidity environment changes, and antibacterial, parasite breed in a large number in the body, when metabolism antibacterial, the residual body of worm, and with the intestinal epithelial cell that comes off, coagulation agglutination agglomerate, and gather to become more large crumb with food debris, form calculus.As tie cholelithiasis: be because the infection of antibacterial can make cholesterol, calcium carbonate, bilirubin be hydrolyzed to unconjugated bilirubin, the unconjugated bilirubin granule, with exfoliative cyte, parasitic ovum etc. be core, in bile under the mucinous help, continuous deposition, formation calculus.
Cholesterol or bile pigments and calcium salt, lipid are gathered and precipitation are taken place gradually and the formation calculus.The crystalline depositions of separating out such as infection, deposition of foreign material, calcium salt that the metabolism aspect causes, unnecessary calcium oxalate, calcium phosphate, uric acid, ammonium magnesium phosphate.(as gastric calculus, nephrolith, liver and gall stone and urinary system calculus etc.) crystalline solid concentration raises, dissolubility reduces, and separates out crystallization to assemble in the part, forms calculus.
Various calculus treatment of diseases methods are: based on above-mentioned mechanism, through research practice, prepared bee honey acid composition, be to make by organic acid and mineral acid, this acid ratio gastric acid (gastric acid only is organic acid) is bigger in the intravital dissolving of people, centrifugation, and stronger sterilization, detoxifcation, antiinflammatory, decomposition, fat melting effect are arranged.Killing bacteria and parasite purify human organ, decompose the toxin of alluvial and food debris, decomposition parasite (ascarid) corpse, keep the slant acidity environment of human body, remove the material base that it produces calculus.Also can dissolve, diminish after the fragmentation and excrete than maximum size.After removing vivotoxin, owing to purified organismic internal environment, isolate, decompose cholesterol, calcium salt and bile pigments also water-soluble, in time excrete by body fluid, make organ divide secret thing can not be detained, deposit, promote to divide secret thing to discharge, improve the unimpeded of each organ pipeline, thereby the formation of prevention calculus can also help liver detoxification, toxin expelling.Decompose crystal such as cholesterol, calcium bilirubinate, lipid, calcium salt, calcium oxalate crystalline substance, calcium phosphate, uric acid, the ammonium magnesium phosphate calculus of formation of deposits.Domestic more generally acknowledged than obtaining at present, dissolved stone medicine chenodeoxycholic acid sheet and ursodesoxycholic acid sheet lithodialysis Li Gengjia.Its lithodialysis principle is: as oral bee honey acid composition, can increase the content of bile acid in the bile, improve that bile dissolving gallbladder is solid, the ability of calcium salt and bile pigments alcohol, from mouth, eat, absorb through the intestines and stomach earlier and enter blood, liver extracts bee honey acid composition to deliver to again calculus just is soaked in this bee honey acid composition from blood, make the Main Ingredients and Appearance dissolving of calculus.And can sterilization, antiinflammatory, anti-stone, decomposition, lithodialysis, calculus, too many levels such as regulate the flow of vital energy treat more all sidedly to calculus, reaches the purpose that various calculus are cured.
The prostatosis pathogeny: the indication prostatosis has (prostatitis, prostatic hyperplasia).The prostatosis root is at the gland poison.Prostate is participated in the male directly and is urinated and the ejaculation behavior, inevitably suffers invasions such as antibacterial, uremic for a long time, and harmful substance day by day deposits, and the gland poison is increasing, and the male has arrived when middle aged, and immunity reduces, and the gland poison is just had an opportunity to take advantage of, comprehensively outburst.Wet, heat, the stasis of blood, hinder, suffer from a deficiency of the kidney, symptoms such as the empty sexual impotence of body, premature ejaculation begin appearance.Human body slant acidity environment changes, and the material of basic fibroblast growth factor causes fibroblast and stromal cell hypertrophy, and then forms the fibre substrate tuberosity, forms the epiderm-like somatomedin again.Body of gland epithelial hyperplasia around this material incentive.And basic fibroblast growth factor and epiderm-like somatomedin are playing an important role aspect prostatic hyperplasia urine retention and the smooth muscle of bladder compensatory hypertrophy.Prostatic blood circulation characteristics are that the arterial blood supply is abundanter, and the venous backflow comparative resistance is bigger, also has fine and close peplos factor in addition, impel the factor of the prolonged and repeated hyperemia of prostate if there is some, just will increase the weight of venous backflow obstacle, local blood is retarded by silt, and causes prostatosis to show effect repeatedly.
Prostata disease treating method is: based on above-mentioned mechanism; through research practice; prepared bee honey acid composition; be to make by organic acid and mineral acid; bigger than gastric acid in the intravital effect of people; organic acid plays replenishing gastric acid, also collaborative gastric acid, protection mucosa, blood vessel, organ pipe wall, repairs the organ pipe damage, the effect of raising body immunity.Mineral acid have stronger sterilization, detoxifcation, antiinflammatory, edema, decomposition, fat melting, in and the effect of alkaline matter, raising metabolism function.Kill the free pathogenic bacteria and the gland poison of deep tissues, improve the permeability of urinate symptom, capsula prostatica, recover the metabolism function of pathological changes body of prostate, improve the sanguimotor condition of diseased region, get through the blood capillary of oppressed obstruction, make the blood circulation at this position be tending towards normal, purify prostate, the material of neutralization, decomposition alkaline fiber cell growth factor decomposes the pus stasis of blood in place poison and the gland, the retraction body of gland recovers urine power.Keep the slant acidity environment of organ, make prostate divide secret thing can not be detained, deposit, promote to divide secret thing to discharge, dredge glandular tube, improve the unimpeded of prostate pipeline, repair and damage the body of gland epithelial cell; Inflammation is faded away.Thereby eliminate many hidden danger that prostatosis shows effect repeatedly, reach the rehabilitation of prostatosis.
Onset diabetes mechanism is: blood be alkalescence its pH value between 7.34-7.45, under the alkali environment, can't remove the free rubbish in the blood vessel in the body metabolism process, cholesterol is a kind of natural glue, not only self can stick together on blood vessel, organ walls, metabolite can also be trapped in fat in the blood vessel, rubbish calcium etc. and be bonded on blood vessel, the organ walls.These materials knot lack into many, just gradually attached to the pancreas blood vessel with carry on the wall pipe of insulin, makes blood vessel, organ from directly stenosis, obstruction, causes dysbolismus.Make carbohydrate, sugar, protein, fat metabolic disturbance, influence the stable of pH value of blood, cause acid base imbalance, insulin all is fugitive and tart, causes insulin defective and biologicalization thereof to act on obstacle under alkaline environment easily.Cause that hyperglycemia, hyperlipidemia, high thickness are the metabolic disease of feature.The hormone of rising blood glucose is a lot of in the human body, and has blood sugar lowering and hormone almost has only insulin a kind of.Because in the body metabolism process, can produce the energy after cholesterol, sugar, fat, the protein that absorbs in the food burnt in vivo, the glucose that sugar is transformed into transports histiocyte to whole body against blood.Must obtain the help by the secreted insulin of pancreas this moment, if this moment, islet cells can not normally divide secret insulin, or the insulin conveyance conduit is obstructed, carries not smooth, cause insulin relative or absolute not enough, make the carbohydrate metabolism dysequilibrium, concentration of glucose raises in the blood, and causes diabetes.
The treatment of diabetes method: based on above-mentioned mechanism, through research practice, prepared bee honey acid composition is to be made by organic acid and mineral acid, and organic acid plays replenishing gastric acid, also collaborative gastric acid, protection mucosa, blood vessel, organ pipe wall, improves immunity.Mineral acid has the free and agglutinating cholesterol of stronger sterilization, detoxifcation, decomposition, rubbish calcium, lipid material, blood sugar regulation, enlarge blood vessel, organ from the footpath, make blood vessel, organ unimpeded, improve the acid-base balance of metabolism function, mediation blood vessel, organ, the secret insulin of normal branch, and it is unobstructed that insulin is carried.Also have a kind of in the Mel and insulin same substance " polypeptide ", have the same effect of insulin, with supplementation with insulin.Thereby reduce hyperglycemia, high blood and full-bodied formation, correct metabolism disorders such as hyperglycemia and hyperlipidemia, impel the homergy of sugar, protein and fat, reach the purpose of curing diabetes.
Medicine is eaten from mouth, needs earlier to enter blood through the intestines and stomach absorption, and liver extracts medicine and delivers in each organ from blood.Chinese medicine has treating different diseases with the same therapeutic principle one to say, be that different diseases is as long as its reason machine is identical, can be different diseases just, but for Most patients wherein, all possess identical cause of disease mechanism with same quadrat method (medicine) treatment intestinal, gastropathy, calculus, prostatosis, diabetes.The six hollow viscera must keep its unobstructed, thereby bee honey acid composition can treat intestinal, gastropathy, calculus, prostatosis, diabetes, prostatosis, just understood easily.
Description of drawings
Fig. 1 is a preparation method flow chart of the present invention.
The specific embodiment
Below in conjunction with example, set forth the present invention.Should be understood that following example only to be used to the present invention is described and, be included in other embodiments in the claim scope not in limit scope of the present invention, can be suitable on an equal basis.
Example 1: be used to prevent and/or treat: 1, intestinal, gastropathy; 2, calculus; 3, prostatosis; 4, diabetes, the bee honey acid composition in the medicine.
Raw materials usedly be: 15-45 ℃ of ethanol, Mel, 〉=31% edible additive hydrochloric acid, water; Its volume ratio is=1-10: 1-70: 1-9: 1-97.
Preferably, in the described bee honey acid composition by: 15-45 ℃ of ethanol, Mel, 〉=31% edible additive hydrochloric acid, water forms; Its volume ratio is=5-10: 10-30: 3-8: 62-82.
Described ethanol is wine or the edible ethanol of alcoholic strength at the 15-45 degree; Described Mel is commercially available high-quality Mel; The edible additive hydrochloric acid that described edible additive hydrochloric acid is 〉=31% concentration/or 36.46 reagent hydrochloric acid solution; Described water is the boiled water that burns till of tap water or mineral water, pure water.
Described bee honey acid composition prevents and/or treats application in intestinal, gastropathy, calculus, prostatosis, the diabetes medicament in preparation.
Described bee honey acid composition also comprises with one or more and prevents and/or treats intestinal, gastropathy, calculus, prostatosis, treatment of diabetes medicine, the same usefulness of agent, to heighten the effect of a treatment or to play synergism.
Described bee honey acid composition is oral liquid formulation or injection dosage form, tablet, capsule, but is not limited thereto.
Described bee honey acid composition also can be applied in any solution, prevents and/or treats, intestinal, gastropathy, calculus, prostatosis, diabetes, but is not limited thereto.
Described bee honey acid composition is characterized in that, described bee honey acid composition adds water 1-100 and doubly dilutes and drink, and prevents and/or treats intestinal, gastropathy, calculus, prostatosis, diabetes, but is not limited thereto.
Bee honey acid composition of the present invention is to preventing and/or treating the medicine of intestinal, gastropathy, calculus, prostatosis, diabetes, and is safe and reliable, and definite, obvious effects are arranged.
Example 2: the preparation method of bee honey acid composition: (as Fig. 1)
After step 103. cooling, add Mel, edible additive hydrochloric acid solution, heat to 20-30 ℃ restir 15 minutes;
It is canned, bottled etc. that bee honey acid composition after standby can carry out, and perhaps purifies and make various medicals.
Example 3: bee honey acid composition in the using method that prevents and/or treats intestinal, gastropathy, calculus, prostatosis, diabetes is:
The method that bee honey acid composition of the present invention is used for the treatment of a kind of recommendation of intestinal, gastropathy, calculus, prostatosis, diabetes is: object average 10-20 milliliter every day that bee honey acid composition of the present invention is needed treatment; Divide four administrations, each 2.5-5 milliliter, directly take (the highest 30 degree that are no more than of water temperature) after stirring with 300-500 milliliter eliminating cold for resuscitation water or mineral water redilution at every turn, clothes get up morning once, the morning, the 9-11 point was obeyed once, afternoon, the 14-17 point was obeyed once, obeyed once before sleeping evening, and three months is a course of treatment.
Example 4: for bee honey acid composition of the present invention is described, to the therapeutic effect of intestinal, gastric disease, intestinal, gastric disease patient that the present invention drinks bee honey acid composition to 132 examples have carried out clinical observation, wherein male's 80 examples, women's 52 examples, the range of age 30-70 year, 51.2 years old mean age; The result shows: among the routine patient, drink 91 examples of recovering normal level in three months; Drink five months intestinal, gastropathy and accuse 30 examples more;
Drink six months intestinal, gastropathy and accuse 11 examples more; Its curative effect such as following table:
| Patient's numbering | Age | Name of disease | Before the treatment | After the treatment |
| 1 | 70 | Ulcerative colitis | Suffered from diarrhea more than 10 year, bad during fashion, defecate one day 4 to 8 times, umbilicus abdominal distention and pain before dawn every day, borborygmus are promptly rushed down, and are afraid of cold soreness of the waist and knees, emaciated physique | Drank two months, and dropped to 2-3 time by original 4-8 time, drank four months, accuse more |
| 2 | 30 | Chronic colitis | Thin 6 months of big loose stool, day row 2～3 times, second shape microscopy: see the mucous membrane of colon Mild edema, vascular lake is unclear, and mucous hyperemia has the point-like petechia | Drank three months, symptom is clearly better, and drinks transference cure, not recurrence in 2 years four months |
| 3 | 57 | Chronic ulcerative colitis | Abdominal pain diarrhea mucosanguineous feces 7 years is surplus, defecates every day 5～6 times, weighs down with the borborygmus anus, abdominal distension and anorexia, spiritlessness and weakness, pale tongue, fibercolonscopy: sigmoid colon and the erosion of mucous membrane of rectum congestion and edema, hemoglobin 6.5 grams | Drank two months, stomachache, diarrhoea, bloody purulent stool disappear.Drank five months, and recovered normal, followed up a case by regular visits to 2 years, do not see recurrence |
| 4 | 42 | Irritable bowel syndrome | Diarrhoea, constipation be alternately surplus in the of ten year, the companion just before stomachache, it is not well to defecate, the time mucus is arranged, insomnia and dreamful sleep, the unsuccessful then sx of feelings will whenever, it is normal to look into the intestinal mirror, gastrointestinal image shows that enterokinesia is very fast | Drank five months, transference cure, 2 years so far surplus, and all are normal |
| 5 | 47 | Chronic enteritis | Diarrhea must be let out once during crow.Darkish complexion, waist soreness, health is become thin, and fear of cold is afraid of cold, and urine is clear, thin white fur of tongue, few Tianjin matter is light, deep-thready pulse and late | Drank four months, all disease knowing are removed, and follow up a case by regular visits to not recurrence after 1 year |
| 6 | 63 | Nonspecific ulcerative colitis | Times of defecation increases during morbidity, reaches every day 5～8 times, is the courageous and upright feces of mucus, and with stomachache and tenesmus, the left lower quadrant tenderness is after outbreak reached 9 years repeatedly.Sigmoidoscopy finds that mucosa has 3 place's festers with congestion and edema | Drank three months, and did the romanoscope check after six months the basic every day 1 time of defecating, except that mucosa is left over cicatrix, surplus all normal |
| 7 | 38 | Colitis | Suffered from superficial gastritis, duodenitis, gastroptosis, colitis before 5 years, hospitalize is invalid, and the state of an illness is on the rise. | Drank two months, and discharged stench flavor stool, drank five months, symptom disappears |
| Remove. | ||||
| 8 | 40 | Erosive proctitis | Normal sense abdominal pain and distension, the flatulence borborygmus, the constipation constipation with dry stool becomes sheep baa dung shape, separates once stool in 5-6 days, sometimes be mingled with a large amount of Mucous Stools, complexion is gloomy, and halitosis is arranged, enteroscopy is a bowel dysfunction, severe erosive proctitis, hemorrhoid | Drank two months, sx, free movement of the bowels was drunk four months, accused more, after patient's intestinal function recovery is normal, had rosy cheeks, and mottle and halitosis disappear |
| 9 | 41 | Gastroenteropathy | The normal abdominal pain of violating, digestive function and bowel movement function are very poor, constipation and diarrhoea alternately, face flesh Huang, skinny and wizened unable, body constitution is very poor, reach 10 before and after the gastropathy surplus year | Drank two months, abdominal distention, stomachache, borborygmus, diarrhoea all alleviate, and appetite takes a turn for the better, and drinks three months, and symptom all disappears |
| 10 | 30 | Gastroenteropathy | Emaciated physique, shallow complexion, dizziness, stomachache, tastelessness, just the inspection: pyocyte a little, erythrocyte, mucosanguineous feces, stool is cultivated (-), fibercolonscopy, colon 18cm section mucosa, edema, hyperemia, courageous and upright mucus secretion is many in the shallow table of rectum 7-8cm place being dispersed in property of intestinal segment, enteric cavity, once uses berberine, gentamycin, the XILEI SAN enema treatment, unsatisfactory curative effect | Drank three months, stool containing pus and blood just disappears, and continue month stool of medication and be shaped, no mucus, no abdominal distention bearing down, microscopy pathological changes intestinal segment, the mild hyperaemia edema is followed up a case by regular visits to and is not had recurrence so far |
| 11 | 55 | Plyability ulcer | Have a stomach-ache, flatulence, pantothenic acid, have the hiccups, have no appetite. | Drank three months, done a painless inspection of full-computerized gastrointestinal, as a result gastric ulcer healing |
| 12 | 62 | Gastroenteropathy | 8 years causes are suffered from gastric ulcer and have been done resection operation (stomach has excised 2/3rds), and partial gastritis appearred in 1 year in postoperative, all day flatulence, uncomfortable in chest, have a stomachache, return acid, watery vomitus, heartburn | Drank two months, symptom is clearly better, drank six months, and state of an illness recovery from illness, the stomach of gas remnants has recovered normal function on inspection, does not see recurrence so far |
| 13 | 34 | Atrophic gastritis | Dysphoria, bitter taste in the mouth and dry throat, hunger but having no desire to eat, gastral cavity abdominal distention is vexed, retches and feels sick, two side of body distending pains, vexed insomnia | Drank the atrophic gastritis recovery from illness three months |
Example 5: for bee honey acid composition of the present invention is described, therapeutic effect to calculus, prostatosis, calculus, prostatosis patient that the present invention drinks bee honey acid composition to 160 examples have carried out clinical observation, wherein male's 80 examples, women's 80 examples, the range of age 26-70 year, 50.7 years old mean age; The result shows: among the routine patient, drink 60 examples of recovering normal level in four months; Drink six months calculus, prostatosiss and accuse 79 examples more; Drink 12 months calculus, prostatosiss and accuse 7 examples more; Its curative effect such as following table:
| Patient's numbering | Age | Name of disease | Before the treatment | After the treatment |
| 12 | 28 | Cholelithiasis | The a plurality of cholelithiasiss of right liver posterior lobe hypomere are beading sample ball and arrange, and are 21 * 8mm to the maximum | Drank ten months, calculus disappears |
| 50 | Cholelithiasis 3 years | Feel sick, vomiting, poor appetite, fever, right abdomen pain, abdominal distention, pain is to right shoulder sometimes.The super calculus 0.4 * 0.6 that shows of B | Drink 20 days patient's pains and increase the weight of, row's black urine; Drink B ultrasonic 0.2 * 0.4 after four months; Recovery from illness after seven months | |
| 3 | 39 | Cholelithiasis | Suffer from gallbladder and be full of type calculus history 2 years, gallbladder 5.7 * 2.7cm.Thickening of capsule wall of gallbladder prompts for the gallbladder muddy stone | Ultrasound diagnosis after ten months, gallbladder recover normal |
| 4 | Calculus in the gallbladder | Right upper quadrant of the abdomen pain at intermittence 1 year, intermittently outbreak, gallbladder size 7.0 * 1.8cm, visible many hot spots in the wall thickness 0.4cm, gallbladder, the granular hot spot gathers into 5.2 * 1.8cm high light group | Took medicine the B ultrasonic further consultation five months: gallbladder size 4.6 * 1.4cm, wall thickness 0.2cm does not see the calculus sound shadow in the gallbladder, calculus is all discharged in 12 months gallbladders | |
| 5 | 66 | The cholelithiasis chronic cholecystitis | Calculus is piled up agglomerating, and size is 55 * 24mm, chronic cholecystitis, and upper right abdomen often has distending pain | Drank 14 months, calculus disappears |
| 6 | 26 | Cholelithiasis | B ultrasonic is looked into: the multiple calculus of right common hepatic duct, and maximum 17 * 8mm, 6 * 4mm, gallbladder thicken and cholecystitis | Drank eight months, calculus disappears |
| 7 | Choledocholithiasis | Calculus 23 * 11mm and expansion, the multiple calculus of stones in intrahepatic bile duct is 23 * 8mm to the maximum, 38 * 8mm, and expansion and a large amount of long-pending | Drank three months, left calculus of intrahepatic duct and choledocholithiasis are eliminated, and the remaining 8mm of right liver frontal lobe calculus of bile duct drinks nine months calculus |
| Gas, the frequent distending pain of right abdomen | Disappear | |||
| 8 | 56 | Urinary system calculus | Because of forming 4.2cm stone bolt, left hydronephrosis 4.0cm in left ureter behind the left kidney rubble | Drank three months, after calculus was discharged, hydronephrosis disappeared, and cured |
| 9 | 45 | Urinary system calculus | Waist ache pain is uncomfortable, the time have hematuria, the time calculus is arranged, the oral Chinese medicine treatment, curative effect is not obvious | Drank seven months, calculus drains only, not recurrence in a year so far |
| 10 | 50 | Renal calculus | Lower abdominal pain, right kidney multiple cyst merges right renal calculus, the about 0.8 * 0.8cm of size | Drank four months, calculus is all discharged, and does not send out in 2 years so far |
| 11 | 56 | The multiple calculus of two kidneys | Maximum 0.8cm, patient's readme pain in the lumbar region has hematuria.It is invalid to do 2 rubbles | Drank five months, and checked through B ultrasonic.Do not see calculus in the kidney |
| 12 | 47 | Renal calculus | Occurred hematuria in 04 year, confirm as right renal calculus merging moderate hydrops through super inspection of B | Drink six first quarter moons, the report of check B ultrasonic is shown: right kidney is normal, loses calculus |
| 13 | 49 | Calculus of bile duct 10 years | Because the position of calculus is special, links to each other with liver, is difficult to the body radioactivity pain of speech table | Drank one month, the pain symptom of whole body disappears, and drinks three months super results that show of B, and calculus disappears. |
| 14 | 55 | Urinary system calculus | B ultrasonic shows renal calculus 0.9 * 0.3, the soreness of waist, dysurea | After four months, B ultrasonic shows that calculus disappears |
| 15 | 48 | The common hepatic duct calculus | Unit finds that common hepatic duct calculus 0.8 * 0.6 size, liver have slight discontinuity pain during health check-up | Month liver's alleviation of pain of taking medicine; Three months check B ultrasonic 0.9 * 0.4, patient's fear thinks that the state of an illness increases the weight of, the length of informing calculus has increased, variation in diameter, illustrate that medicine has produced curative effect, advise it to continue to drink, calculus disappeared in five months |
| 16 | 57 | Vesical calculus | Frequent micturition, urgent micturition and the pain of urinating, urine stream are interrupted the companion suddenly and are had an intense pain and be radiated to perineal position or Glans penis, and changing can continue again to urinate or repeat urine stream behind the position interrupts.B ultrasonic shows calculus 1.3 * 0.6 | Take medicine and urinate not bitterly in a week, B ultrasonic shows calculus 1.0 * 0.6 after taking medicine three months; B ultrasonic showed calculus 0.6 * 0.2 in five months; B ultrasonic demonstration bladder was not seen the enhancing shade in six months |
| 17 | 39 | Renal calculus | The intermittent pain in kidney district, a left side is generally all based on dull pain.B ultrasonic left side kidney 1 * 0.9 calculus | After the medication one month, painful subtracting, B ultrasonic 0.6 * 0.5 after March; Six months 0.3 * 0.2; After serveing on 1 year |
| Recovery from illness | ||||
| 18 | 60 | Ureteral calculus | Angor, from waist, to radiation such as hypogastric region, pudendum, the pain scope is big along ureter, and angor is a burst of, and is short then a few minutes, long then reach a few hours.Look into B ultrasonic and show ureteral calculus many places calculus | Took medicine the aggravation of feel pain, the sand-like thing of folder black in the urine in the time of 20 days, alleviation of pain eight days; Aftersensation in March defecation is unobstructed; The check B ultrasonic shows to have only place's calculus not disappear, and seven months, unexpected angor was with a face streaming with sweat during defecation, and the residue calculus is discharged in urine and healed |
Example 6: drink the part prostatosis case of bee honey acid composition treatment of the present invention, its curative effect such as following table:
| Patient's numbering | Age | Name of disease | Before the treatment | After the treatment |
| 1 | 37 | Prostatitis 3 years | Frequent micturition, urgent micturition, dysurea, premature ejaculation. | Three months frequent micturitions, urgent micturition, dysurea takes a turn for the better, and premature ejaculation took a turn for the better in five months. |
| 2 | 50 | Prostatic hyperplasia | Frequent micturition, urine is waited for, is got up in the night to urinate 4 times. | Three months urine is waited for and being taken a turn for the better; Got up in the night to urinate in four months and be kept to 3 times; Got up in the night to urinate in six months 1 time, sexual function recovers. |
| 3 | 60 | Prostatic hyperplasia | Frequent micturition, urine is waited for, is got up in the night to urinate 6 times. | Four months urine is waited for and being taken a turn for the better; Got up in the night to urinate in six months and be kept to 3 times; Got up in the night to urinate in eight months 1 time, play erection morning. |
| 4 | 70 | Vesical calculus merges hyperplasia of prostate | Pollakiuria, urodynia, dysuria, urinate interruption, hematuria, bladder area are taken the photograph X line plain film and are shown calculus shade 1.6 * 1.1 | Four months, hematuria took a turn for the better; It is more preceding unobstructed to urinate after six months; Serve on JIUYUE calculus announcement and remove, play erection morning. |
| 5 | 48 | The chlamydia prostatitis | Yellowish urine, urethral orifice are rubescent, dysurea, perineal position distending pain increased the weight of 2 years.The obvious enlargement of bilateral prostate presses pain (++), chemical examination prostatic fluid WBC (+++), corpusculum (++), prostate liquid antibacterial culturing chlamydia (+). | Three months, twinge was clearly better; Six months, the symptom complete obiteration; Through check chlamydia feminine gender, clinical symptom disappearance. |
| 6 | 41 | The chronic prostatitis prostate increases | Frequent micturition, dysurea appearred before 3 years, abdomen dull pain, rectal tenesmus, | Two months, urethral stimulant transference cure, unobstructed micturition, property merit |
| Greatly | Urine is waited for, symptoms such as nocturia increases, premature ejaculation. | Can also obtain rehabilitation. | ||
| 7 | 57 | Prostatic hyperplasia | Frequent micturition, urgent micturition, nocturia 3-4 time have the urine retention sense, the urine back sound of rain pattering.Physical examination: prostate such as egg size, color ultrasound show prostate anteroposterior diameter 4cm, and form is rule still, interior hylperadenosis, and the external gland attenuation, Pericarpium Citri Reticulatae disease (+), echo is low. | After four months, patient's frequent micturition, symptoms of urgency obviously alleviate; The urine retention sense thoroughly recovers after seven months; Check color ultrasound after nine months, prostate is normal fully, after 1 year, checks color ultrasound once more, and prostate is not seen hypertrophy. |
Example 7: for bee honey acid composition of the present invention is described, to the treatment of diabetes effect, the diabetics that the present invention drinks bee honey acid composition to 150 examples has carried out clinical observation, wherein male's 80 examples, women's 70 examples, the range of age 27-76 year, 49.3 years old mean age; The result shows: among the routine patient, drink 30 examples of recovering normal level in four months; Drink eight months diabetes and accuse 87 examples more; Drink 16 months diabetes and accuse 27 examples more; Its curative effect such as following table:
| Patient's numbering | Age | Before the treatment (the fasting glucose mM/liter) | The treatment back (the fasting glucose mM/liter) |
| 1 | 32 | Fasting glucose 6.7 | Drink and reduced to 4.5 in five months |
| 2 | 46 | Fasting glucose 6.9 | Drink and reduced to 5.6 in five months |
| 3 | 27 | Fasting glucose 7.7 | Drink and reduced to 6.3 in six months |
| 4 | 40 | Fasting glucose 7.1 | Drink and reduced to 5.5 in six months |
| 5 | 54 | Fasting glucose 8.3 | Drink and reduced to 6.4 in seven months |
| 6 | 49 | Fasting glucose 8.4 | Drink and reduced to 5.9 in seven months |
| 7 | Fasting glucose 8.7 | Drink and reduced to 6.7 in five months | |
| 8 | 55 | Fasting glucose 7.0 (clothes antidiabetic drug) | Drink the dose minimizing of four months years, drink with ten months disconnected medicines and reduce to 5.1 |
| 9 | 60 | Fasting glucose 7.7 (clothes antidiabetic drug) | The dose minimizing of five months years is drunk 12 months disconnected medicines and is reduced to 5.3 |
| 10 | 51 | Fasting glucose 7.5 (clothes antidiabetic drug) | The dose minimizing of five months years is drunk 12 months disconnected medicines and is reduced to 5.3 |
| 11 | 43 | Fasting glucose 7.9 (clothes antidiabetic drug) | The dose minimizing of five months years is drunk 12 months disconnected medicines and is reduced to 5.3 |
| 12 | 72 | Fasting glucose 8.4 (the about insulin injection of clothes blood sugar lowering) | Drink six months disconnected medicines, annotate the amount of insulin and do not fall, blood glucose reduces to 7.1, drinks ten months injection volumes and subtracts 1/3 blood glucose and reduce to 5.7 |
| 13 | 37 | Fasting glucose 9.6 (clothes antidiabetic drug insulin injection) | Drink seven months disconnected medicines, blood glucose reduces to 7.7, drinks 12 months injection volumes and subtracts 1/2, and blood glucose reduces to 6.2 |
| 14 | 57 | Blood glucose 13 (clothes antidiabetic drug insulin injection) | Drink eight months disconnected medicines, annotate the amount of insulin and do not fall, blood glucose is reduced to 7.9, ten three month injection volumes and is subtracted 1/3 blood glucose and reduce to 6.7 |
| 15 | 62 | Blood glucose 18.6 is often uncomfortable in chest, insomnia, bipod are numb, urine not frequently, often insomnia was only slept two or three hours in one day sometimes, serious is left lower limb is rotting, the fingernail blackout, is beating islets of langerhans＜long-acting〉noons 30 unit, evenings 28 unit, blood glucose does not reach normally all the time | Drank nine months, insulin is reduced to 10 units noon, the insulin of stopping using evening, 16 months disconnected medicines, blood glucose 6.7 does not have pain, the part of festering incrustation, fingernail has not hardened in blackout yet, not recurrence in 2 years |
| 16 | 76 | Two hours after the meal blood glucose 19.5 of blood glucose 12.8 | 11 months, blood glucose reduced to 5.7. |
| 17 | 76 | Blood glucose 12.8 (clothes antidiabetic drug) | Drink 1 year dose and reduce by half, disconnected medicine blood glucose reduced to 6.6 in 13 months |
| 18 | 60 | Blood glucose 15mmol/L glucose in urine ++ ++, albumen ++ ketoboidies +++, accompanied with hypertension, retinal hemorrhage, blurred vision, vulva pruritus, numbness of hands and feet, ice-cold, nervous, breathe hard, weak from head to foot, upstairs lower limb is moved, and a moving cold perspiration grows up the building | Drank seven months, legs and feet energetically can have been strolled in doors, take 12 months all transference cures of disconnected medicine, can downstairs take a walk, and blood glucose is reduced to 5.3mmol/L. |
| 19 | 53 | Blood glucose 7.2 (clothes antidiabetic drug) | Drink and reduced to 6.1, six months disconnected medicines in four months and reduce to 5.3 |
| 20 | 70 | Edema of lower limbs, blurred vision appear, polydipsia, polyuria, dizziness, dark tongue quality, white, the stringy and thready pulse of tongue.According to the nearest blood glucose 8.1mmol/L of patient | After drinking May, blood glucose 6.9mmol/L, transference cure after ten months, disconnected medicine blood glucose reduces to 6.4 |
By table as seen, bee honey acid composition of the present invention is used to prevent and/or treat intestinal, gastropathy, calculus, prostatosis, diabetes comparatively tangible curative effect.
Should be understood that in addition after having read foregoing of the present invention, those skilled in the art can make various changes or modifications the present invention, these similar type fall within the application institute restricted portion equally.
Claims (9)
1, a kind of bee honey acid composition is characterized in that, described bee honey acid composition mainly is to be prepared from by following raw materials according: 15-45 ℃ of ethanol, 64-70% Mel, more than or equal to 31% edible additive hydrochloric acid, water; Its volume ratio is 1-10: 1-70: 1-9: 1-97.
2, bee honey acid composition as claimed in claim 1 is characterized in that, the volume ratio of described ethanol, Mel, edible additive hydrochloric acid, water is 5-10: 10-30: 3-8: 62-82.
3, bee honey acid composition as claimed in claim 1 or 2 is characterized in that, described ethanol is that alcoholic strength is the wine or the edible ethanol of 15-45 degree; Described Mel is commercially available high-quality Mel; The edible additive hydrochloric acid that described edible additive hydrochloric acid is 〉=31% concentration/or reagent hydrochloric acid solution; Described water is the boiled water that burns till of tap water or mineral water, pure water.
4, bee honey acid composition as claimed in claim 1 or 2 prevents and/or treats application in intestinal, gastropathy, calculus, prostatosis, the diabetes in preparation.
5, bee honey acid composition as claimed in claim 1 or 2 also comprise with one or more treatment intestinal, gastropathy, calculus, prostatosis, diabetes prevent and/or treat medicine, the same usefulness of agent, to heighten the effect of a treatment or to play synergism.
6, bee honey acid composition as claimed in claim 1 or 2 is characterized in that, described bee honey acid composition is oral liquid formulation or injection dosage form, tablet, capsule.
7, bee honey acid composition as claimed in claim 1 or 2 is characterized in that, described bee honey acid composition can be applicable in the solution.
8, bee honey acid composition as claimed in claim 1 or 2 is characterized in that, described bee honey acid composition adds water 1-100 and doubly dilutes and drink, and prevents and/or treats intestinal, gastropathy, calculus, prostatosis, diabetes.
9, a kind of preparation method of bee honey acid composition is characterized in that, comprises the steps:
Step 1. is mixed ethanol, water, and reacting by heating is to 100-120 ℃, and the mixing that refluxes; Stirred 5-20 minute, and made mixed liquor;
Step 2. is filtered above-mentioned mixed liquor;
After step 3. cooling, add Mel, edible additive hydrochloric acid solution, heat to 20-30 ℃ restir 15 minutes;
Step 4. is filtered above-mentioned mixed liquor, and it is standby to form bee honey acid composition.
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| CN200810056956.8 | 2008-01-28 | ||
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| CNA2008100947059A CN101327225A (en) | 2008-01-28 | 2008-05-04 | Bee honey acid composition and preparation method and uses thereof |
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| CNA2008100947059A Pending CN101327225A (en) | 2008-01-28 | 2008-05-04 | Bee honey acid composition and preparation method and uses thereof |
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| CN101249108B (en) * | 2008-01-28 | 2010-07-28 | 朱光勇 | Royal jelly acidic composition, preparation and uses thereof |
| RU2415611C1 (en) * | 2009-11-30 | 2011-04-10 | Общество С Ограниченной Ответственностью "Парафарм" | Biologically active food supplement for disease prevention and heart-vascular system recovery |
| CN102659569B (en) * | 2012-03-12 | 2014-04-02 | 昆明固康保健品有限公司 | Royal jelly acid calcium, and health product for antiatherosclerosis and antiosteoporosis prepared from royal jelly acid calcium and vitamin K2 |
| CN105902565A (en) * | 2016-05-11 | 2016-08-31 | 吴健忠 | Method for reversing sclerosis of artery and other soft tissues |
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| CN1057583A (en) * | 1990-06-27 | 1992-01-08 | 张洪昌 | A kind of method for making of kidney-tonifying and yang-strengthening oral solution |
| JPH1132705A (en) * | 1997-07-17 | 1999-02-09 | Yakult Honsha Co Ltd | Granular food and its production |
| CN1285184A (en) * | 1999-08-18 | 2001-02-28 | 珲春图们江精细化工研究院 | Amino acid face-nourishing drink |
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