CN101249108B - Royal jelly acidic composition, preparation and uses thereof - Google Patents
Royal jelly acidic composition, preparation and uses thereof Download PDFInfo
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- CN101249108B CN101249108B CN2008100854247A CN200810085424A CN101249108B CN 101249108 B CN101249108 B CN 101249108B CN 2008100854247 A CN2008100854247 A CN 2008100854247A CN 200810085424 A CN200810085424 A CN 200810085424A CN 101249108 B CN101249108 B CN 101249108B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
The invention relates to a royal jelly-acid mixture and a preparation method and an application thereof. The royal jelly-acid mixture contains 3-5% acetic acid, 15-65% (v/v) ethanol, 64.5-69.55% royal jelly, 31-385% hydrochloric acid and water, in volume ratio of (1-10):(1-10):(1-70):(1-9):(1-96). The royal jelly-acid mixture can be used for the prevention and treatment of hypertension and cardiovascular and cerebrovascular diseases with remarkable effectiveness and high safety.
Description
Technical field
The present invention relates to pharmacy, relate in particular to a kind of acidic composition and preparation method and application thereof, be used for the treatment of hypertension and because of cardiovascular and cerebrovascular vessel are stopped up or sclerosis causes a series of diseases.
Background technology
Medical circle thinks that the hypertensive cause of disease of initiation is a lot of at present, generally is divided into: 1, essential hypertension, and wherein inherited genetic factors accounts for 40%, and environmental factors accounts for 60%.2, secondary hypertension, the renal hypertension that causes by kidney disease, secreted hypertension that endocrinopathy causes etc., medical science is not made clear as yet fully to the hypertensive cause of disease, so can not effect a radical cure so far, the hyperpietic is in case confirm and will take medicine, must take medicine all the life, still do not have radical cure method this be definitely the fact.
In the time of hypertension, the patient often has sense of discomfort in various degree, and for example headache, head rise etc., influence work and life.In addition, complication takes place in long-term hypertension easily, in case take place, heavy then fatal, gently then disable, can return to normal person fully seldom.Because of the death that hypertension and cardiovascular disease cause, accounted for the first place of the human cause of death.Therefore there is the people to claim that vascular hypertension is " invisible killer ".
Up to the present, the medicine that various preventions or treatment hypertension cardiovascular and cerebrovascular disease have been arranged on the market, but a series of diseases that these medicines all do not have thoroughly to effect a radical cure hypertension and cardiovascular and cerebrovascular disease and complication (as hypertensive heart disease, coronary heart disease, myocardial infarction, apoplexy, cerebral thrombosis, cerebral hemorrhage, cerebral blood supply insufficiency, cerebral infarction) and cause because of cerebrovascular atherosclerosis or obstruction, and also there is such-and-such toxic and side effects in these medicines.
Summary of the invention
In order to solve the existing variety of issue of said medicine, the present invention proposes a kind of starch Royal Jelly acid mixture and preparation method thereof and the application in treatment hypertension and a series of disease medicaments of causing because of cerebrovascular atherosclerosis or obstruction thereof, its purpose is effectively to remove intravital calcium-calmodulin complex, stops itself and target enzyme silk to split plain activated protein kinase, somatomedin and the vasoactive factor and combines; Suppress vascular smooth muscle cell proliferation, eliminate vascular smooth muscle early lesion fat stricture of vagina, fibrous plaque.Effectively prevention and treatment hypertension and because of cardiovascular and cerebrovascular vessel are stopped up or sclerosis causes a series of diseases.
The invention discloses a kind of royal jelly acid mixture mixture, comprise 3-5% acetic acid, 15-65 degree ethanol, 64.5-69.5% Lac regis apis, 31-38% hydrochloric acid and water, volume ratio is: 3-5% acetic acid: 15-65 degree ethanol: 64.5-69.5% Lac regis apis: 31-38% hydrochloric acid: water=1-10: 1-10: 1-70: 1-9: 1-96.
Described acetic acid is one of white vinegar, malic acid, citric acid or combination; Described ethanol is that alcoholic strength is wine or edible ethanol; Described Lac regis apis is commercially available high-quality or general Lac regis apis; Described hydrochloric acid is the hydrochloric acid of 31-38% concentration.
Described royal jelly acid mixture prevents and/or treats application in the medicine of hypertension and cardiovascular and cerebrovascular disease in preparation.
Described royal jelly acid mixture, it is characterized in that, be used to prevent and/or treat hypertension and cardiovascular and cerebrovascular disease, in the described royal jelly acid mixture, 3-5% acetic acid: 15-65 degree ethanol: 64.5-69.5% Lac regis apis: 31-38% hydrochloric acid: the volume ratio of water is: 5-10: 5-10: 30-60: 3-8: 22-47.
Described royal jelly acid mixture also comprises with curative, the agent of one or more treatment hypertension and cardiovascular and cerebrovascular disease to be used together.
Described royal jelly acid mixture is oral liquid formulation or injection dosage form.
The invention also discloses a kind of preparation method of royal jelly acid mixture, comprise the steps:
After step 103. cooling, add Lac regis apis, hydrochloric acid solution, heat to 20-30 ℃ restir 15 minutes;
It is canned, bottled etc. that royal jelly acid mixture after standby can carry out, and perhaps purifies and make various medicals and health preparation.
The formation mechanism and the effect of a series of diseases that the present invention causes to hypertension and because of cerebrovascular atherosclerosis or obstruction are as follows,
1, owing to can be trapped in the blood vessel by a lot of metabolic wastes of generation in the body metabolism process, comprises cholesterol crystal, triglyceride, various rubbish calcium etc.Calcium-calmodulin complex wherein, directly splitting plain activated protein kinase with target enzyme silk combines, somatomedin and the vasoactive factor (Endothelin, angiotensin thrombin etc.) can activate above-mentioned conjugate, impel vascular smooth muscle cell proliferation, vascular smooth muscle cell and monocytic cell ingests blood cholesterol and be converted into foam cell, form blood vessel early lesion fat stricture of vagina, form fibrous plaque on this basis, long-term accumulation causes blood vessel to thicken hardening, elastic force weakens, atherosclerosis causes angiostenosis, stop up, thus the generation of initiation hypertension and cardio-cerebralvascular diseases; For example cause coronary heart disease, cause cerebral infarction etc. in the cerebral arteries deposition in the coronary artery deposition.
2, part of the calcium in the blood and protein bound, part flows in blood with the calcium ion of ion band positive charge.Calcium ion is all arranged inside and outside the vascular smooth muscle cell, in case a large amount of calcium ions enter in the cell from the extracellular, just with intracellular calmodulin, CaM combination, make cell be excitatory state, the myocyte just shrinks, this means that vascular smooth muscle shrinks, and the arteries contraction causes vascular resistance to increase and makes hypertension.
According to above mechanism is the generation of prophylaxis of hypertension disease and a series of diseases for the treatment of established hypertension and causing because of cerebrovascular atherosclerosis or obstruction, the present invention is according to interrelated data explanation and repeatedly practice, press a certain amount of proportioning with different organic acid and mineral acid, invented a kind of safe and practical royal jelly acid mixture, through facts have proved a series of diseases that to prevent and treat hypertension effectively and cause because of cerebrovascular atherosclerosis or obstruction.
Royal jelly acid mixture provided by the invention is to cure mainly hypertension and the effectively material of complication thereof.It in the intravasation, removes calcium in the blood vessel-calmodulin complex combination fast, stops itself and target enzyme silk to split plain activated protein kinase, somatomedin and the vasoactive factor (Endothelin, angiotensin thrombin etc.) and combines; Suppress vascular smooth muscle cell proliferation, eliminate and form blood vessel early lesion fat stricture of vagina, fibrous plaque on the vascular smooth muscle.Activate the blood vessel cytoactive, strengthen blood vessel elasticity, reduce lipid peroxide and produce, eliminate vasospasm, blood viscosity lowering alleviates the load of contraction of vascular resistance and arteries and diastole, suppress platelet aggregation and thrombosis, alleviate peripheral blood vessel and capillary embolism.Dissolving arterial blood tube wall fat speckle and fat mud deposition and various rubbish calcium, by body fluid (being mainly urine) it is excreted, reach and remove the purpose adhere to, be deposited on the rubbish in blood vessel wall and the blood, recover blood vessel from the footpath so that bring high blood pressure down, hypertension and complication thereof just can be eliminated.
Description of drawings
Fig. 1 is a preparation method flow chart of the present invention.
The specific embodiment
Below in conjunction with embodiment, set forth the present invention.Should be understood that following example only to be used to the present invention is described and, be included in other embodiments in the claim scope not in limit scope of the present invention, can be suitable on an equal basis.
One, the preparation of royal jelly acid mixture
Embodiment 1: the royal jelly acid mixture that is used for the treatment of hypertension and cardiovascular and cerebrovascular disease
Raw materials used and ratio (volume ratio): 3-5% acetic acid: 15-65 degree ethanol: 64.5-69.5% Lac regis apis: 31-38% hydrochloric acid: water; Volume ratio is 1-10: 1-10: 1-70: 1-9: 1-96.
Preferably, in the described royal jelly acid mixture, 3-5% acetic acid, 15-65 degree ethanol, 64.5-69.5% Lac regis apis, 31-38% hydrochloric acid, water, its preparation volume ratio is=5-10: 5-10: 30-60: 3-8: 22-47.
Medicinal efficacy according to acetic acid, ethanol, Lac regis apis, hydrochloric acid, water, the present invention with these five kinds of solvents by a certain percentage (volume ratio), temperature to be mixed with a kind of royal jelly acid mixture (in scope safely and effectively) oral, in order to prevent and treat its a series of diseases that cause because of cerebrovascular atherosclerosis or obstruction of hypertension.
The various edible vinegar of the optional self-contained acetic acid of described acetic acid, for example one of white vinegar, malic acid, citric acid or combination.The main effect of vinegar in this royal jelly acid of the present invention mixture has: multiple diseases such as vessel softening, prophylaxis of hypertension, hyperlipidemia, cerebral thrombosis, arteriosclerosis; The immunity of blood circulation promoting, raising human body; Have slow down aging, eliminate human body fatigue, remove rubbish, appetite-stimulating indigestion-relieving, Antialcoholic liver-protecting in the body.
Described ethanol can be selected from various drinks and the edible ethanol that alcoholic strength is the 15-65 degree, for example Chinese liquor, yellow wine, wine etc.Ethanol main effect in royal jelly acid mixture of the present invention is: relaxing muscles and tendons and activating QI and blood in the collateral, activating blood circulation to dissipate blood stasis, the row efficacy of a drug, promote to absorb, increase metabolic rate, and make this royal jelly acid mixture enter human vas, organ, blood capillary fast, arrive the affected part and strengthen drug effect.
Described Lac regis apis can be the secretions of cultivating young worker bee (nurse honeybee) the pharynx gland of larva in the honeycomb.Lac regis apis main effect in royal jelly acid mixture of the present invention is: through scientific research for many years and clinical medicine facts have proved both at home and abroad, Lac regis apis has peculiar effect to human medical treatment, health care etc.: (1), improve nutrition, replenish mentality: contain a large amount of nutrients in the Lac regis apis, often eat and to improve underfed situation, treatment inappetence, dyspepsia, people's muscle power, mentality are strengthened, and emotion improves; (2), improve body immunity: contain immunoglobulin in the Lac regis apis, can significantly improve body immunity, edible Lac regis apis is after a period of time, and it is full of physical strength that people obviously feel, catches a cold and the probability of other disease has reduced; (3), the prophylactic treatment cardiovascular and cerebrovascular disease, taking Lac regis apis for a long time all has better curative effect to disease patients such as three fat abnormality diseases, sclerosis of blood vessels, arrhythmias.
Described hydrochloric acid can be the hydrochloric acid of 31-38%, preferred edible hydrochloric acid.The main effect of hydrochloric acid in royal jelly acid mixture of the present invention is: delay and remove lipid such as cholesterol and adhere in blood vessel wall, dissolve various calcium substances to deposit on blood vessel wall, help the digestion and the absorption of protein, fat., dissolving favourable to blood circulation and cardiovascular and cerebrovascular vessel and remove blood vessel, organ rubbish, sterilization in the body with the vinegar combined effect.Concentration of hydrochloric acid is extremely rare in royal jelly acid mixture of the present invention, can not cause stimulation to human body, and is nontoxic, harmless, safe and reliable.In addition, hydrochloric acid also can reduce the micro-safety knot compound ethyl acetate of ethanol and acetic acid, to improve curative effect.
Described water can be selected from various drinkable water, the boiled water or the mineral water that burn till as tap water.The main effect of water in royal jelly acid mixture of the present invention is: Digestion, drain refuse, supply with nutrition and oxygen branch, balance body temperature, promote gastrointestinal peristalsis, keep cell function, keep lymph and blood circulation, blood vessel, organ rubbish, toxin in the dissolve body, dilute blood, the effect of carrying this royal jelly acid mixture and substance in vivo and medium, impel the concentration of hydrochloric acid in metabolism, the dilution raw material, make royal jelly acid mixture of the present invention be controlled at one and in the safe and reliable scope the human body edible.
Preparation method, see Fig. 1:
After step 103. cooling, add Lac regis apis, hydrochloric acid solution, heat to 20-30 ℃ restir 15 minutes;
Two, the using method of royal jelly acid mixture
The method that royal jelly acid mixture of the present invention is used for the treatment of a kind of recommendation of hypertension and cardiovascular and cerebrovascular disease is: object average 10-20 milliliter every day that royal jelly acid mixture of the present invention is needed treatment; Divide four administrations, each 2.5-5 milliliter directly takes (the highest 30 degree that are no more than of water temperature) at every turn after stirring with 300-500 milliliter eliminating cold for resuscitation water or mineral water, clothes get up morning once, and the morning, the 9-11 point was obeyed once, and afternoon, the 14-17 point was obeyed once, obey once before sleeping evening, three months is a course of treatment.
For the therapeutic effect of royal jelly acid mixture of the present invention to hypertension and cardiovascular and cerebrovascular disease is described, hypertension and cardiovascular and cerebrovascular disease patient that the present invention takes the royal jelly acid mixture to 116 examples have carried out clinical observation, wherein male's 43 examples, women's 73 examples, the range of age 40-80 year, 65.5 years old mean age; The result shows: among the 116 routine patients, take six months controlling of blood pressure, 33 examples at normal level; Take 2 years controlling of blood pressure 80 examples at normal level; Three routine blood pressures descend to some extent but do not reach in the normal scope; Effective percentage 97.4%.
Drink the part hypertension case curative effect such as the following table of royal jelly acid mixture treatment of the present invention:
| Name | Age | Name of disease | Before the treatment | After the treatment |
| 1, Wu | 71 | Hypertension | Hypertension 13 years, blood pressure | Blood pressure 130/85 after 6 months, head |
| 60/100 headache, dizziness, tinnitus, cardiopalmus, dim eyesight, absent minded, hypomnesis, numbness of hands and feet, fatigue and weak. | Diseases such as pain disappear; Blood pressure 110/80 after 9 months; It is normal that blood pressure was followed up a case by regular visits in drug withdrawal in 1 year, do not have other discomforts. | |||
| 2, Zhang | 61 | Hypertension | 19 years (taking depressor) blood pressure 140/90 companions are dizzy for hypertension, blurred vision. | Used 3 months, depressor is stopped using, blood pressure 120/85; 6 months drug withdrawal blood pressures 110/80, all diseases disappear. |
| 60/100 headache, dizziness, tinnitus, cardiopalmus, dim eyesight, absent minded, hypomnesis, numbness of hands and feet, fatigue and weak. | Diseases such as pain disappear; Blood pressure 110/80 after 9 months; It is normal that blood pressure was followed up a case by regular visits in drug withdrawal in 1 year, do not have other discomforts. | |||
| 3, the Meng | 55 | Hypertension | Hypertension 6 years has family history, clothes depressor blood pressure 150/125, cardiopalmus, dim eyesight. | Withdraw depressor, take the bleeding from anus voltage rise to 160/130 in 30 days of this medicine, blood pressure 135/85 after 6 months, and diseases such as headache disappear; Blood pressure 120/85 after 10 months; It is normal that blood pressure was followed up a case by regular visits in drug withdrawal in 1 year, do not have other discomforts. |
| 4, Zhu | 53 | Hypertension | Hypertension 3 years, blood pressure 140/110 | Drink that dose reduces by half after 1 year, 1.5 years disconnected medicines were refused to obey any depressor so far in 2 years, and blood pressure is 120/80. |
| 5, money | 69 | Hypertension | Hypertension 9 years, blood pressure 170/100 | Drank 14 months, the dose blood pressure stabilization that reduces by half is drunk 2 years disconnected medicines, and blood pressure is 110/70. |
| 6, the week certain | 40 | Hypertension | Hypertension 3 years, blood pressure 150/105 | Drink disconnected medicine after 2 years, now refused to obey depressor in 1 year, blood pressure stabilization is 130/80. |
| 7, beam | 45 | Hypertension | Hypertension 4 years, blood pressure 140/110 | Drink after 1 year disconnected medicine, blood pressure is 130/80 now to refuse to obey depressor in 2 years, and blood pressure stabilization is 130/80. |
| 8, Zhao | 53 | Hypertension | Hypertension 11 years, blood pressure 160/100 | Drink disconnected medicine after 2 years, now refused to obey depressor in 1 year, blood pressure is 130/85. |
| 60/100 headache, dizziness, tinnitus, cardiopalmus, dim eyesight, absent minded, hypomnesis, numbness of hands and feet, fatigue and weak. | Diseases such as pain disappear; Blood pressure 110/80 after 9 months; It is normal that blood pressure was followed up a case by regular visits in drug withdrawal in 1 year, do not have other discomforts. | |||
| 9, Wang certain | 62 | Hypertension | Hypertension 5 years, blood pressure 145/100 | Drink that dose reduces by half after 1 year, blood pressure is 110/90. |
| 10, season | 80 | Hypertension companion varicose veins of the lower extremity | Hypertension 23 years, varicose veins of the lower extremity 15 years, blood pressure 160/90, two skin of lower extremity blackening, ulceration, the Lumbricus shape is through pimple. | Drink disconnected medicine after 2 years, refused to obey that now any depressor blood pressure is 130/85 in 1 year; Skin color recovers, and the Lumbricus shape flattens through pimple. |
| 11, surplus certain | 67 | The hypertension companion | Hypertension 9 years, blood pressure | Drink that dose reduces by half blood after 3 years |
| Diabetes | 180/85, blood glucose 14mmol/L | Pressure is 130/80.Blood glucose 9mmol/L | ||
| 12, Liu | 53 | Hypertension | Hypertension 6 years, blood pressure 150/90 | Drink disconnected medicine after 2 years, now refused to obey any depressor in 1.5 years, blood pressure is 135/75. |
| 13, close certain | 68 | Hypertension | Hypertension 5 years, blood pressure 160/100 | Drink disconnected medicine after 2 years, now do not attend pressing in 1 year, blood pressure is 120/80. |
| 14, journey | 66 | Hypertension | Hypertension 3 years, blood pressure 170/95 | Drink disconnected medicine after 2 years, now do not take medicine in 1 year, blood pressure is 120/80. |
| Diabetes | 180/85, blood glucose 14mmol/L | Pressure is 130/80.Blood glucose 9mmol/L | ||
| 15, Yuan | 72 | Hypertension | Hypertension 12 years, (taking depressor) blood pressure 180/110 | After drinking 2 years, dose reduces by half, and existing blood pressure is 130/70. |
| 16, land | 62 | Hypertension | Hypertension 8 years, blood pressure 170/110 | Drink after 2 years disconnected medicine, now 1 refused to obey depressor, blood pressure is 140/90. |
| 17, Chen | 64 | Hypertension | Hypertension 14 years, (taking depressor) blood pressure 160/90 | Drink disconnected medicine after 2 years, now do not take medicine in 2 years, blood pressure is 125/80. |
| 18, the flood certain | 64 | Hypertension | Hypertension 18 years, (taking depressor) blood pressure 150/100 | Drink disconnected medicine after 2 years, now do not take medicine in 1 year, blood pressure is 130/75. |
| 19, Wang | 70 | Hypertension | Hypertension 20 years (clothes blood pressure depressor), blood pressure 160/110 | Drink disconnected medicine after 19 months, now do not take medicine in 6 months, blood pressure is 130/75. |
| 20, Lee | 68 | Hypertension | Hypertension 7 years, blood pressure 145/95 | Drink disconnected medicine after 1.5 years, existing blood pressure is 120/70. |
By table as seen, royal jelly acid mixture of the present invention is used for the treatment of the hypertension cardio-cerebrovascular diseases comparatively significantly curative effect.
Should be understood that in addition after having read foregoing of the present invention, those skilled in the art can make various changes or modifications the present invention, these similar type fall within the application institute restricted portion equally.
Claims (7)
1. royal jelly acid mixture, it is characterized in that, described royal jelly acid mixture comprises 3-5% acetic acid, 15-65 degree ethanol, 64.5-69.5% Lac regis apis, 31-38% hydrochloric acid and water, and volume ratio is: 3-5% acetic acid: 15-65 degree ethanol: 64.5-69.5% Lac regis apis: 31-38% hydrochloric acid: water=1-10: 1-10: 1-70: 1-9: 1-96.
2. mixture acid as claimed in claim 1 is characterized in that, described acetic acid is selected from one of the white vinegar that comprises acetic acid, malic acid, citric acid or combination.
3. royal jelly acid mixture as claimed in claim 1 prevents and/or treats application in the medicine of hypertension and cardiovascular and cerebrovascular disease in preparation.
4. as claim 2 or 3 described royal jelly acid mixture, it is characterized in that, be used to prevent and/or treat hypertension and cardiovascular and cerebrovascular disease, in the described royal jelly acid mixture, 3-5% acetic acid: 15-65 degree ethanol: 64.5-69.5% Lac regis apis: 31-38% hydrochloric acid: the volume ratio of water is=5-10: 5-10: 30-60: 3-8: 22-47.
5. royal jelly acid mixture as claimed in claim 4 is characterized in that, described royal jelly acid mixture also comprises with the healing potion of one or more treatment hypertension and cardiovascular and cerebrovascular disease to be used together.
6. royal jelly acid mixture as claimed in claim 4 is characterized in that, described royal jelly acid mixture is oral liquid formulation or injection dosage form.
7. the preparation method of the described royal jelly acid mixture of claim 1 is characterized in that, comprises the steps:
Step 1. is mixed acetic acid, ethanol, water, and reacting by heating stirred 5-20 minute to 100-120 ℃, and refluxes and make mixed liquor;
Step 2. is filtered above-mentioned mixed liquor;
After step 3. cooling, add Lac regis apis, hydrochloric acid solution, heat to 20-30 ℃ restir 15 minutes;
Step 4. is filtered above-mentioned mixed liquor, and it is standby to form the royal jelly acid mixture.
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| CN101249108B (en) * | 2008-01-28 | 2010-07-28 | 朱光勇 | Royal jelly acidic composition, preparation and uses thereof |
| RU2415611C1 (en) * | 2009-11-30 | 2011-04-10 | Общество С Ограниченной Ответственностью "Парафарм" | Biologically active food supplement for disease prevention and heart-vascular system recovery |
| CN102659569B (en) * | 2012-03-12 | 2014-04-02 | 昆明固康保健品有限公司 | Royal jelly acid calcium, and health product for antiatherosclerosis and antiosteoporosis prepared from royal jelly acid calcium and vitamin K2 |
| CN105902565A (en) * | 2016-05-11 | 2016-08-31 | 吴健忠 | Method for reversing sclerosis of artery and other soft tissues |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1057583A (en) * | 1990-06-27 | 1992-01-08 | 张洪昌 | A kind of method for making of kidney-tonifying and yang-strengthening oral solution |
| CN1285184A (en) * | 1999-08-18 | 2001-02-28 | 珲春图们江精细化工研究院 | Amino acid face-nourishing drink |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1132705A (en) * | 1997-07-17 | 1999-02-09 | Yakult Honsha Co Ltd | Granular food and its production |
| CN101249108B (en) * | 2008-01-28 | 2010-07-28 | 朱光勇 | Royal jelly acidic composition, preparation and uses thereof |
-
2008
- 2008-03-14 CN CN2008100854247A patent/CN101249108B/en not_active Expired - Fee Related
- 2008-03-19 WO PCT/CN2008/000541 patent/WO2009094811A1/en active Application Filing
- 2008-05-04 CN CNA2008100947059A patent/CN101327225A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1057583A (en) * | 1990-06-27 | 1992-01-08 | 张洪昌 | A kind of method for making of kidney-tonifying and yang-strengthening oral solution |
| CN1285184A (en) * | 1999-08-18 | 2001-02-28 | 珲春图们江精细化工研究院 | Amino acid face-nourishing drink |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101327225A (en) | 2008-12-24 |
| CN101249108A (en) | 2008-08-27 |
| WO2009094811A1 (en) | 2009-08-06 |
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