CA2843120A1 - Seed dressing for controlling phytopathogenic fungi - Google Patents

Seed dressing for controlling phytopathogenic fungi Download PDF

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Publication number
CA2843120A1
CA2843120A1 CA2843120A CA2843120A CA2843120A1 CA 2843120 A1 CA2843120 A1 CA 2843120A1 CA 2843120 A CA2843120 A CA 2843120A CA 2843120 A CA2843120 A CA 2843120A CA 2843120 A1 CA2843120 A1 CA 2843120A1
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seed
plants
products known
methyl
pyrenophora
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CA2843120A
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French (fr)
Inventor
Anne Suty-Heinze
Peter Dahmen
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Bayer Intellectual Property GmbH
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Bayer Intellectual Property GmbH
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    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings

Abstract

The present invention relates to the use of Fluopyram for seed treatment, for corresponding seed dressings comprising Fluopyram, to a process for controlling phytopathogenic fungi by treating the seed with Fluopyram, and also to seed which has been treated with Fluopyram.

Description

Seed dressing for controlling phytopathogenic fungi The present invention relates to the use of Fluopyram for seed treatment, for corresponding fungicides and insecticides seed dressings comprising Fluopyram, to a process for controlling phytopathogenic fungi by treating the seed with Fluopyram, and also to seed which has been treated with Fluopyram.
Fluopyram is defined to be the compound of the formula (I) CF3.--CI

I
III
H (I) as well as the N-oxides of the compound thereof Fluopyram is a broad spectrum fungicide with penetrant and translaminar properties for foliar, drip, drench and seed treatment applications on a wide range of different crops against many economically important plant diseases. It is very effective in preventative applications against powdery mildew species, grey mould and white mould species. It has an efficacy against many other plant diseases.
Fluopyram has shown activity in spore germination, germ tube elongation and mycelium growth tests.
At the biochemical level, fluopyram inhibits mitochondrial respiration by blocking the electron transport in the respiratory chain of Succinate Dehydrogenase (complex II - SDH
inhibitor).
Fluopyram and its manufacturing process starting from known and commercially available compounds is described in EP-A- 1 389 614 and WO 2004/016088.
The use of these compounds for treating seed for protection against attack by seed- borne phytopathogenic fungi has hitherto not been disclosed. In particular, the use of these compounds as seed dressing for protection against attack by Pyrenophora species is new.
It has now been found that Fluopyram is highly suitable for treating (dressing) seed against attack by phytopathogenic fungi.
Surprisingly, by using Fluopyram according to the invention as seed dressing, some phytopathogenic fungi can be controlled considerably more effectively than by spray treatment in the case of foliar application.
The active compounds according to the invention have very good fungicidal properties and, in seed treatment, are particularly suitable for controlling phytopathogenic fungi, such as Ascomycetes and
- 2 -Deuteromycetes. In seed treatment, the active compounds according to the invention are particularly suitable for controlling seed borne Pyrenophora species.
Some pathogens causing fungal diseases which come under the generic names listed above may be mentioned by way of example, but not by way of limitation:
Seed-borne Pyrenophora species, such as, for example, P. avenae, P. graminea, P. teres, P.
semen iperda, P. tritici-repentis The fact that the active compounds which can be used are well tolerated by plants at the concentrations required for controlling plant diseases permits a treatment of the seed.
Accordingly, the active compounds according to the invention can be used as seed dressings.
A large part of the damage to crop plants which is caused by phytopathogenic fungi occurs as early as when the seed is attacked during storage and after the seed is introduced into the soil, during and immediately after germination of the plants. This phase is particularly critical since the roots and shoots of the growing plant are particularly sensitive and even minor damage can lead to the death of the whole plant. Protecting the seed and the germinating plant by the use of suitable compositions is therefore of particularly great interest.
The control of phytopathogenic fungi which damage plants post-emergence is carried out primarily by treating the soil and the above-ground parts of plants with crop protection agents. Owing to the concerns regarding a possible impact of crop protection agents on the environment and the health of man and animals, there are efforts to reduce the amount of active compounds applied.
The control of phytopathogenic fungi by treating the seeds of plants has been known for a long time and is subject-matter of continuous improvements. However, the treatment of seed frequently entails a series of problems which cannot always be solved in a satisfactory manner. Thus, it is desirable to develop methods for protecting the seed and the germinating plant which dispense with the additional application of crop protection agents after sowing or after the emergence of the plants or where additional applications are at least reduced. It is furthermore desirable to optimize the amount of active compound employed in such a way as to provide maximum protection for the seed and the germinating plant from attack by phytopathogenic fungi, but without damaging the plant itself by the active compound employed. In particular, methods for the treatment of seed should also take into consideration the intrinsic fungicidal properties of transgenic plants in order to achieve optimum protection of the seed and the germinating plant with a minimum of crop protection agents being employed.
The present invention therefore in particular also relates to a method for the protection of seed and germinating plants from attack by phytopathogenic fungi, by treating the seed with a composition according to the invention.
- 3 -The invention likewise relates to the use of the compositions according to the invention for the treatment of seed for protecting the seed and the germinating plant from phytopathogenic fungi.
Furthermore, the invention relates to seed which has been treated with a composition according to the invention so as to afford protection from phytopathogenic fungi.
One of the advantages of the present invention is that the particular systemic properties of the compositions according to the invention mean that treatment of the seed with these compositions not only protects the seed itself, but also the resulting seedlings after germination, from phytopathogenic fungi. In this manner, the immediate protection of the crop at the time of sowing or shortly thereafter can be dispensed with.
Furthermore, it must be considered as advantageous that the mixtures according to the invention can also be employed in particular in transgenic seed.
The compositions according to the invention are suitable for protecting seed of any plant variety which is employed in agriculture, in the greenhouse, in forests or in horticulture.
In particular, this takes the form of seed of cereals (such as wheat, barley, rye, millet and oats), maize, cotton, soya beans, rice, potatoes, sunflowers, beans, coffee, beet (for example sugar beet and fodder beet), peanuts, vegetables (such as tomatoes, cucumbers, onions and lettuce), lawns and ornamental plants. The treatment of seed of cereals (such as wheat, barley, rye and oats) is of particular importance.
In the context of the present invention, the composition according to the invention is applied to the seed either alone or in mixtures with other compounds (fungicides and/or insecticides and/or biological control agents) in a suitable formulation. The composition according to the invention applied to the seed may contain further components as fertilisers, growth promoters and/or inert carriers in a suitable formulation Preferably, the seed is treated in a state which is stable enough to avoid damage during treatment. In general, the seed may be treated at any point in time between harvest and sowing. The seed usually used has been separated from the plant and freed from cobs, shells, stalks, coats, hairs or the flesh of the fruits. Thus, for example, it is possible to use seed which has been harvested, cleaned and dried to a moisture content of below 15% by weight. Alternatively, it is also possible to use seed which, after drying, has, for example, been treated with water and then dried again.
The following fungicides can be used in combination with the compound according to formula (I) fluopyram:
(1) Inhibitors of the ergosterol biosynthesis, for example (1.1) aldimorph (1704-28-5), (1.2) azaconazole (60207-31-0), (1.3) bitertanol (55179-31-2), (1.4) bromuconazole (116255-48-2), (1.5) cyproconazole (113096-99-4), (1.6) diclobutrazole (75736-33-3), (1.7) difenoconazole (119446-68-3), (1.8) diniconazole (83657-24-3), (1.9) diniconazole-M (83657-18-5), (1.10) dodemorph (1593-77-7), (1.11)
- 4 -dodemorph acetate (31717-87-0), (1.12) epoxiconazole (106325-08-0), (1.13) etaconazole (60207-93-4), (1.14) fenarimol (60168-88-9), (1.15) fenbuconazole (114369-43-6), (1.16) fenhexamid (126833-17-8), (1.17) fenpropidin (67306-00-7), (1.18) fenpropimorph (67306-03-0), (1.19) fluquinconazole (136426-54-5), (1.20) flurprimidol (56425-91-3), (1.21) flusilazole (85509-19-9), (1.22) flutriafol (76674-21-0), (1.23) furconazole (112839-33-5), (1.24) furconazole-cis (112839-32-4), (1.25) hexaconazole (79983-71-4), (1.26) imazalil (60534-80-7), (1.27) imazalil sulfate (58594-72-2), (1.28) imibenconazole (86598-92-7), (1.29) ipconazole (125225-28-7), (1.30) metconazole (125116-23-6), (1.31) myclobutanil (88671-89-0), (1.32) naftifine (65472-88-0), (1.33) nuarimol (63284-71-9), (1.34) oxpoconazole (174212-12-5), (1.35) paclobutrazol (76738-62-0), (1.36) pefurazoate (101903-30-4), (1.37) penconazole (66246-88-6), (1.38) piperalin (3478-94-2), (1.39) prochloraz (67747-09-5), (1.40) propiconazole (60207-90-1), (1.41) prothioconazole (178928-70-6), (1.42) pyributicarb (88678-67-5), (1.43) pyrifenox (88283-41-4), (1.44) quinconazole (103970-75-8), (1.45) simeconazole (149508-90-7), (1.46) spiroxamine (118134-30-8), (1.47) tebuconazole (107534-96-3), (1.48) terbinafine (91161-71-6), (1.49) tetraconazole (112281-77-3), (1.50) triadimefon (43121-43-3), (1.51) triadimenol (89482-17-7), (1.52) tridemorph (81412-43-3), (1.53) triflumizole (68694-11-1), (1.54) triforine (26644-46-2), (1.55) triticonazole (131983-72-7), (1.56) uniconazole (83657-22-1), (1.57) uniconazole-p (83657-17-4), (1.58) viniconazole (77174-66-4), (1.59) voriconazole (137234-62-9), (1 .60) 1-(4-chloropheny1)-2-(1H-1,2,4-triazol-1 -yl)cyc loheptanol (129586-32-9), (1.61) methyl 1-(2,2-dimethy1-2,3-dihydro-1H-inden-l-y1)-1H-imidazole-5-carboxylate (110323-95-0), (1 . 62 ) N'- {5-(difluoromethyl)-2-methyl-4- [3 -(trimethylsilyl)prop oxy]phenyl} -N-ethyl-N-methylimidofor mamide, (1.6 3) N-ethyl-N-methyl-N'- {2-methy1-5-(trifluoromethyl)-443-(trimethylsily1)pr op o xy ] pheny 1 } imi do form ami de and (1.6 4) 041-(4-methoxyphenoxy)-3,3-dimethylbutan-2-yl] 1H-imidazole-1-carbothioate (111226-71-2).
(2) inhibitors of the respiratory chain at complex I or II, for example (2.1) bixafen (581809-46-3), (2.2) boscalid (188425-85-6), (2.3) carboxin (5234-68-4), (2.4) diflumetorim (130339-07-0), (2.5) fenfuram (24691-80-3), (2.7) flutolanil (66332-96-5), (2.8) fluxapyroxad (907204-31-3), (2.9) furametpyr (123572-88-3), (2.10) furmecyclox (60568-05-0), (2.11) isopyrazam (mixture of syn-epimeric racemate 1RS,4SR,9RS and anti-epimeric racemate 1RS,4SR,9SR) (881685-58-1), (2.12) isopyrazam (anti-epimeric racemate 1RS,4SR,9SR), (2.13) isopyrazam (anti-epimeric enantiomer 1R,4S,9S), (2.14) isopyrazam (anti-epimeric enantiomer 1S,4R,9R), (2.15) isopyrazam (syn epimeric racemate 1RS,4SR,9RS), (2.16) isopyrazam (syn-epimeric enantiomer 1R,4S,9R), (2.17) isopyrazam (syn-epimeric enantiomer 1S,4R,9S), (2.18) mepronil (55814-41-0), (2.19) oxycarboxin (5259-88-1), (2.20) penflufen (494793-67-8), (2.21) penthiopyrad (183675-82-3), (2.22) sedaxane (874967-67-6), (2.23) thi fluz amid e ( 1 3 0 0 0 0-40-7), (2.24) 1-methyl-N42-(1,1,2,2-tetrafluoroethoxy)pheny1]-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide, (2.25) 3 -(difluoromethyl)-1-methyl-N- [241,1,2,2-tetrafluoroethoxy)pheny1]-1H-pyrazole-4-carboxamide, (2.26) 3-(difluoromethyl)-N-[4-fluoro-2-(1,1,2,3,3,3-hexafluoropropoxy)pheny1]-1-methyl-1H-pyrazole-4-c arb ox am i d e , ( 2 . 2 7 ) N-[1-(2,4-dichloropheny1)-1-methoxyprop an-2-yl] -3 -(difluoromethyl)-1-methy1-1H-pyrazole-4-carb oxamide
- 5 -(1092400-95-7) (WO 2008148570), (2.28) 5,8-difluoro-N-[2-(2-fluoro-4-{[4-(trifluoromethyl)pyridin-2-yl] oxy}phenyl)ethyl]quinazolin-4-amine (1210070-84-0) (W02010025451), (2.29) N- [9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl] -3 -(difluoromethyl)-1-methy1-1H-pyrazole-4-carb oxamide, (2.30) N- [(1 S,4R)-9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl] -3 -(difluoromethyl)-1-methy1-1H-pyrazo le-4-carb oxamide and (2.31) N-[(1R,4 S)-9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]
-3 -(difluoromethyl)-1-methy1-1H-pyrazo le-4-carb oxamide, N- [9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaph-thalen-5-yl] -3 -(difluoromethyl)-1 -methyl-1H-pyrazole-4-carb oxamide.
(3) inhibitors of the respiratory chain at complex III, for example (3.1) ametoctradin (865318-97-4), (3.2) amisulbrom (348635-87-0), (3.3) azoxystrobin (131860-33-8), (3.4) cyazofamid (120116-88-3), (3.5) coumethoxystrobin (850881-30-0), (3.6) coumoxystrobin (850881-70-8), (3.7) dimoxystrobin (141600-52-4), (3.8) enestroburin (238410-11-2) (WO 2004/058723), (3.9) famoxadone (131807-57-3) (WO 2004/058723), (3.10) fenamidone (161326-34-7) (WO 2004/058723), (3.11) fenoxystrobin (918162-02-4), (3.12) fluoxastrobin (361377-29-9) (WO 2 0 04/058723), (3.13) kresoxim-methyl (143390-89-0) (WO 2004/058723), (3.14) metominostrobin (133408-50-1) (WO
2004/058723), (3.15) orysastrobin (189892-69-1) (WO 2004/058723), (3.16) picoxystrobin (117428-22-5) (WO
2004/058723), (3.17) pyraclostrobin (175013-18-0) (WO 2004/058723), (3.18) pyrametostrobin (915410-70-7) (WO 2004/058723), (3.19) pyraoxystrobin (862588-11-2) (WO
2004/058723), (3.20) pyribencarb (799247-52-2) (WO 2004/058723), (3.21) triclopyricarb (902760-40-1), (3.22) trifloxystrobin (141517-21-7) (WO 2004/058723), (3.23) (2E)-2-(2- { [6-(3-chloro-2-methylphenoxy)-5-fluoropyrimidin-4-yl]oxy}pheny1)-2-(methoxyimino)-N-methylethanamide (WO
2004/058723), (3.24) (2E)-2-(methoxyimino)-N-methyl-2-(2- { [( { (1E)-1- [3 -(trifluoromethyl)phenyl] ethylidene} amino)oxy]-methyl}phenyl)ethanamide (WO 2004/058723), (3.25) (2E)-2-(methoxyimino)-N-methyl-2- {2-[(E)-({1-[3 -(trifluoromethyl)phenyl] ethoxy } imino)methyl] phenyl } ethanamide (158169-73-4), (3.26) (2E)-2- {2-[( { [(1E)-1 -(3- { [(E)-1- fluoro-2-phenylethenyl] oxy } phenyl) ethylidene]
amino} oxy)methyl]phenyl} -2-(methoxyimino)-N-m e thyle than ami d e (3 26 89 6-28-0), (3.27) (2E)-2- {2-[( {[(2E,3E)-4-(2,6-dichlorophenyl)but-3-en-2-ylidene]amino}oxy)methyl]pheny1}-2-(methoxyimino)-N-methyl-eth an amid e, (3 . 2 8) 2-chloro-N-(1,1,3-trimethy1-2,3-dihydro-1H-inden-4-yl)pyridine-3-carboxamide (119899-14-8), (3.29) 5-methoxy-2-methyl-4-(2- { [( { (1E)-1- [3 -(trifluoromethyl)-3 0 phenyl] ethylidene} amino) oxy] methyl} phenyl)-2,4- dihydro-3H-1,2,4-triazol-3 -one, (3.30) methyl (2E)-2- {2- [( {cyclopropyl[(4-methoxyphenyl)imino]methyl} sulfanyl)methyl]phenyl} -3 -methoxyprop-2-eno ate (1 4 9 6 0 1-03-6), (3.31) N-(3-ethy1-3,5,5-trimethylcyclohexyl)-3-(formylamino)-2-hydroxybenzamide (226551-21-9), (3.32) 2- {2-[(2,5-dimethylphenoxy)methyl]phenyl} -2-methoxy-N-methylacetamide (173662-97-0) and (3.33) (2R)-2- {2-[(2,5-dimethylphenoxy)methyl]phenyl} -2-methoxy-N-methylacetamide (394657-24-0).
(4) Inhibitors of the mitosis and cell division, for example (4.1) benomyl (17804-35-2), (4.2) carbendazim (10605-21-7), (4.3) chlorfenazole (3574-96-7), (4.4) diethofencarb (87130-20-9), (4.5)
- 6 -ethaboxam (162650-77-3), (4.6) fluopicolide (239110-15-7), (4.7) fuberidazole (3878-19-1), (4.8) pencycuron (66063-05-6), (4.9) thiabendazole (148-79-8), (4.10) thiophanate-methyl (23564-05-8), (4.11) thiophanate (23564-06-9), (4.12) zoxamide (156052-68-5), (4.13) 5-chloro-7-(4-methylpiperidin-1-y1)-6-(2,4,6-trifluoropheny1)[1,2,4]triazolo[1,5-a]pyrimidine (214706-53-3) and (4.14) 3-chloro-5-(6-chloropyridin-3-y1)-6-methy1-4-(2,4,6-trifluorophenyl)pyridazine (1002756-87-
7).
(5) Compounds capable to have a multisite action, like for example (5.1) bordeaux mixture (8011-63-0), (5.2) captafol (2425-06-1), (5.3) captan (133-06-2) (WO 02/12172), (5.4) chlorothalonil (1897-45-6), (5.5) copper hydroxide (20427-59-2), (5.6) copper naphthenate (1338-02-9), (5.7) copper oxide (1317-39-1), (5.8) copper oxychloride (1332-40-7), (5.9) copper(2+) sulfate (7758-98-7), (5.10) dichlofluanid (1085-98-9), (5.11) dithianon (3347-22-6), (5.12) dodine (2439-10-3), (5.13) dodine free base, (5.14) ferbam (14484-64-1), (5.15) fluorofolpet (719-96-0), (5.16) folpet (133-07-3), (5.17) guazatine (108173-90-6), (5.18) guazatine acetate, (5.19) iminoctadine (13516-27-3), (5.20) iminoctadine alb esilate (169202-06-6), (5.21) iminoctadine triacetate (57520-17-9), (5.22) mancopper (53988-93-5), (5.23) mancozeb (8018-01-7), (5.24) maneb (12427-38-2), (5.25) metiram (9006-42-2), (5.26) metiram zinc (9006-42-2), (5.27) oxine-copper (10380-28-6), (5.28) propamidine (104-32-5), (5.29) propineb (12071-83-9), (5.30) sulphur and sulphur preparations including calcium polysulphide (7704-34-9), (5.31) thiram (137-26-8), (5.32) tolylfluanid (731-27-1), (5.33) zineb (12122-67-7) and (5.34) ziram (137-30-4).
(6) Compounds capable to induce a host defence, for example (6.1) acibenzolar-S-methyl (135158-54-2), (6.2) isotianil (224049-04-1), (6.3) probenazole (27605-76-1) and (6.4) tiadinil (223580-51-6).
(7) Inhibitors of the amino acid and/or protein biosynthesis, for example (7.1) andoprim (23951-85-1), (7.2) blasticidin-S (2079-00-7), (7.3) cyprodinil (121552-61-2), (7.4) kasugamycin (6980-18-3), (7.5) kasugamycin hydrochloride hydrate (19408-46-9), (7.6) mepanipyrim (110235-47-7), (7.7) pyrimethanil (53112-28-0) and (7.8) 3-(5-fluoro-3,3,4,4-tetramethy1-3,4-dihydroisoquinolin-1-y1)quinoline (861647-32-7) (W02005070917).
(8) Inhibitors of the ATP production, for example (8.1) fentin acetate (900-95-8), (8.2) fentin chloride (639-58-7), (8.3) fentin hydroxide (76-87-9) and (8.4) silthiofam (175217-20-6).
(9) Inhibitors of the cell wall synthesis, for example (9.1) benthiavalicarb (177406-68-7), (9.2) dimethomorph (110488-70-5), (9.3) flumorph (211867-47-9), (9.4) iprovalicarb (140923-17-7), (9.5) mandipropamid (374726-62-2), (9.6) polyoxins (11113-80-7), (9.7) polyoxorim (22976-86-9), (9.8) validamycin A (37248-47-8) and (9.9) valifenalate (283159-94-4; 283159-90-0).
(10) Inhibitors of the lipid and membrane synthesis, for example (10.1) biphenyl (92-52-4), (10.2) chloroneb (2675-77-6), (10.3) dicloran (99-30-9), (10.4) edifenphos (17109-49-8), (10.5) etridiazole (2593-15-9), (10.6) iodocarb (55406-53-6), (10.7) iprobenfos (26087-47-8), (10.8) isoprothiolane (50512-35-1), (10.9) propamocarb (25606-41-1), (10.10) propamocarb hydrochloride (25606-41-1), (10.11) prothiocarb (19622-08-3), (10.12) pyrazophos (13457-18-6), (10.13) quintozene (82-68-8), (10.14) tecnazene (117-18-0) and (10.15) tolclofos-methyl (57018-04-9).
(11) Inhibitors of the melanine biosynthesis, for example (11.1) carpropamid (104030-54-8), (11.2) diclocymet (139920-32-4), (11.3) fenoxanil (115852-48-7), (11.4) phthalide (27355-22-2), (11.5) pyroquilon (57369-32-1), (11.6) tricyclazole (41814-78-2) and (11.7) 2,2,2-trifluoroethyl {3-methy1-1-[(4-methylbenzoyl)amino]butan-2-yl}carbamate (851524-22-6) (W02005042474).
(12) Inhibitors of the nucleic acid synthesis, for example (12.1) benalaxyl (71626-11-4), (12.2) benalaxyl-M (kiralaxyl) (98243-83-5), (12.3) bupirimate (41483-43-6), (12.4) clozylacon (67932-85-8), (12.5) dimethirimol (5221-53-4), (12.6) ethirimol (23947-60-6), (12.7) furalaxyl (57646-30-7), (12.8) hymexazol (10004-44-1), (12.9) metalaxyl (57837-19-1), (12.10) metalaxyl-M
(mefenoxam) (70630-17-0), (12.11) ofurace (58810-48-3), (12.12) oxadixyl (77732-09-3) and (12.13) oxolinic acid (14698-29-4).
(13) Inhibitors of the signal transduction, for example (13.1) chlozolinate (84332-86-5), (13.2) fenpiclonil (74738-17-3), (13.3) fludioxonil (131341-86-1), (13.4) iprodione (36734-19-7), (13.5) procymidone (32809-16-8), (13.6) quinoxyfen (124495-18-7) and (13.7) vinclozolin (50471-44-8).
(14) Compounds capable to act as an uncoupler, for example (14.1) binapacryl (485-31-4), (14.2) dinocap (131-72-6), (14.3) ferimzone (89269-64-7), (14.4) fluazinam (79622-59-6) and (14.5) meptyldinocap (131-72-6).
(15) Further compounds, for example (15.1) benthiazole (21564-17-0), (15.2) bethoxazin (163269-30-5), (15.3) capsimycin (70694-08-5), (15.4) carvone (99-49-0), (15.5) chinomethionat (2439-01-2), (15.6) pyriofenone (chlazafenone) (688046-61-9), (15.7) cufraneb (11096-18-7), (15.8) cyflufenamid (180409-60-3), (15.9) cymoxanil (57966-95-7), (15.10) cyprosulfamide (221667-31-8), (15.11) dazomet (533-74-4), (15.12) debacarb (62732-91-6), (15.13) dichlorophen (97-23-4), (15.14) diclomezine (62865-36-5), (15.15) difenzoquat (4 9 8 6 6-87-7), (15.16) difenzoquat methylsulphate (43222-48-6), (15.17) diphenylamine (122-39-4), (15.18) ecomate, (15.19) fenpyrazamine (473798-59-3), (15.20) flumetover (154025-04-4), (15.21) fluoroimide (41205-21-4), (15.22) flusulfamide (106917-52-6), (15.23) flutianil (304900-25-2), (15.24) fosetyl-aluminium (39148-24-8), (15.25) fosetyl-calcium, (15.26) fosetyl-sodium (39148-16-8), (15.27) hexachlorobenzene (118-74-1), (15.28) irumamycin (81604-73-1), (15.29) methasulfocarb (66952-49-6), (15.30) methyl isothiocyanate (556-61-6), (15.31) metrafenone (220899-03-6), (15.32) mildiomycin (67527-71-3), (15.33) natamycin (7681-93-8), (15.34) nickel dimethyldithiocarbamate (15521-65-0), (15.35) nitrothal-isopropyl (10552-74-6), (15.36) octhilinone (26530-20-1), (15.37) oxamocarb (9 1 72 4 2-12-7), (15.38) oxyfenthiin (34407-87-9), (15.39) pentachlorophenol and salts (87-86-5), (15.40) phenothrin, (15.41) phosphorous acid and its salts (13598-36-2), (15.42) propamocarb-fosetylate, (15.43) propanosine-sodium (88498-02-6), (15.44) proquinazid (189278-12-4), (15.45) pyrimorph (868390-90-3), (15.45e) (2E)-3-(4-tert-butylpheny1)-3-(2-chloropyridin-4-y1)-1 -(morpho lin-4-yl)prop-2- en-1- one (1231776-28-5), (15.45z) (2Z)-3 -(4-tert-butylpheny1)-3 -(2-chloropyridin-4-y1)-1-(morpho lin-4-yl)prop-2- en-1- one (1231776-29-6), (15.46) pyrrolnitrine (1018-71-9) (EP-A 1 559 320), (15.47) tebufloquin (376645-78-2), (15.48) tecloftalam (76280-91-6), (15.49) tolnifanide (304911-98-6), (15.50) triazoxide (72459-58-6), (15.51) trichlamide (70193-21-4), (15.52) zarilamid (84527-51-5), (15.53) (3 S,6S,7R,8R)-8-benzy1-34( {3-[(isobutyryloxy)methoxy] -4-methoxypyridin-2-y1} carb onyl)amino] -6-methy1-4,9-dioxo-1,5-dioxonan-7-yl 2-methylpropanoate (517875-34-2) (W02003035617), (15.54) 1-(4- {4-[(5R)-5-(2,6-difluoropheny1)-4,5-dihydro-1,2-oxazol-3-y1]-1,3-thiazol-2-yl}piperidin-1-y1)-2-[5-methy1-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone (1003319-79-6) (WO 2 0 0 8 0 1 3 6 2 2 ) , ( 1 5 . 5 5 ) 1-(4-{4-[(5S)-5-(2,6-difluoropheny1)-4,5-dihydro-1,2-oxazol-3-yl] -1,3-thiazol-2-y1} pip eridin-l-y1)-2- [5-methy1-3-(trifluoromethyl)-1H-pyrazol-1-yl] ethanone (1003319-80-9) (WO 2008013622), (15.56) 1-(4- {445-(2,6-difluoropheny1)-4,5-dihydro-1,2-oxazol-3-yl] -1,3-thiazol-2-y1} piperidin-l-y1)-2- [5-methy1-3-(trifluoromethyl)-1H-pyrazol-1-yl] ethanone (1003318-67-9) (WO 2 0 0 8 0 1 3 6 2 2 ), ( 1 5 .5 7) 1-(4-methoxyphenoxy)-3,3 -dimethylbutan-2-y1 1H-imidazo le-1 -carb oxylate (111227-17-9), (15.58) 2,3,5,6-tetrachloro-4-(methylsulfonyl)pyridine (13108-52-6), (15.59) 2,3-dibuty1-6-chlorothieno [2,3-d]pyrimidin-4(3H)- one (221451-58-7), (15.60) 2,6-dimethy1-1H,5H- [1,4]
dithiino [2,3-c:5,6-c'] dipyrrole-1,3,5,7(2H,6H)-t etrone, (1 5.6 1) 2-[5-methyl-3 -(trifluoromethyl)-1H-pyrazol-1 -y1]-1-(4- {4- [(5R)-5 -pheny1-4,5-dihydro-1,2- oxazol-3 -yl] -1,3 -thiazol-2-y1} p ip eridin-l-y1) ethanone (1003316-53-7) ( W 0 2008013622), (15.62) 2- [5-methy1-3-(trifluoromethyl)-1H-pyrazol-1-yl] -1-(4-{4-[(5S)-5-phenyl-4,5-dihydro-1,2-oxazol-3-yl] -1,3-thiazol-2-y1} pip eridin- 1 -yl)ethanone (1003316-54-8) (WO 2008013622), (1 5.63) 2- [5-methy1-3-(trifluoromethyl)-1H-pyrazol-1-yl] -1- {4- [4-(5 -pheny1-4,5-dihydro-1,2-oxazol-3-y1)-1,3-thiazol-2-yl]pip eridin-1 -yl } ethanone (1003316-51-5) (WO
2008013622), (15.64) 2-butoxy-6-iodo-3-propy1-4H-chromen-4-o n e, ( 1 5 . 65 ) 2-chloro-5-[2-chloro-1-(2,6-difluoro-4-methoxypheny1)-4-methy1-1H-imidazol-5-yl]pyridine, (15.66) 2-phenylphenol and salts (90-43-7), (15.67) 3-(4,4,5-trifluoro-3,3-dimethy1-3,4-dihydroisoquinolin-1-y1)quinoline (861647-85-0) (W02005070917), (15.68) 3,4,5-trichloropyridine-2,6-dicarbonitrile (17824-85-0), (15.69) 3- [5-(4-chloropheny1)-2,3-dimethy1-1,2-oxazolidin-3-y l]pyridine, (1 5.7 0) 3-chloro-5-(4-chloropheny1)-4-(2,6-difluoropheny1)-6-methylpyridazine, (15.71) 4-(4-chloropheny1)-5-(2,6-difluoropheny1)-3,6-dimethylpyridazine, (15.72) 5-amino-1,3,4-thiadiazole-2-thiol, (15.73) 5-chloro-N'-phenyl-N'-(prop-2-yn-1-yl)thiophene-2-3 0 sulfonohydrazide (134-31-6), (15.74) 5-fluoro-2- [(4-fluorob enzyl) oxy]pyrimidin-4-amine (1174376-11-4) (W02009094442), (15.75) 5-fluoro-2-[(4-methylbenzyl)oxy]pyrimidin-4-amine (1174376-25-0) (W02009094442), (15.76) 5-methyl-6-octyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, (15.77) ethyl (2Z)-3-amino-2-cyano-3-phenylprop-2-e no ate, (1 5.7 8) N '-(4- {[3-(4-chlorobenzy1)-1,2,4-thiadiazol-5-yl]oxy} -2,5-dimethylpheny1)-N-ethyl-N-methylimidoformamide, (15.79) N-(4-chlorob enzy1)-3- [3-methoxy-4-(prop-2-yn-1-yloxy)phenyl]propanamide, (15.80) N- [(4-chlorophenyl)(cyano)methyl] -3- [3-methoxy-4-(prop-2-yn-l-y loxy )p heny 1 ] pr op an ami d e , (1 5 . 8 1) N-[(5-bromo-3-chloropyridin-2-yl)methy1]-2,4-dichloropyridine-3-carboxamide, (15.82) N- [1-(5-bromo-3-chloropyridin-2-yl)ethyl] -2,4-dichloropyridine-3-carb oxamide, (15.83) N-[1-(5-bromo-3-chloropyridin-2-yl)ethy1]-2-fluoro-4-iodopyridine-3-carboxamide, (15.84) N- { (E)- [(cyclopropylmethoxy)imino] [6-(difluoromethoxy)-2,3-difluorophenyl]methy1}-2-phenylacetamide (221201-92-9), (15.85) N- {(Z)-[(cyclopropylmethoxy)imino] [6-(difluoromethoxy)-2,3 -difluorophenyl] methyl }
-2-phenylacetamide (221201-92-9), (15.86) N'- {4- [(3-tert-buty1-4-cyano-1,2-thiazol-5-yl)oxy]-2-chloro-5-methylphenyl} -N-ethyl-N-methylimidoformamide, (15.87) N-methy1-2-(1- { [5-methy1-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl} pip eridin-4-y1)-N-(1,2,3,4-tetrahydronaphthalen-l-y1)-1,3 -thiazo le-4-c arb ox am i de ( 922514-49-6) (WO
2007014290), (15.88) N-methy1-2-(1- { [5-methy1-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl} pip eridin-4-y1)-N- [(1R)-1,2,3,4-tetrahydronaphthalen-l-yl] -1,3 -thiazo le-4-carb oxamide (922514-07-6) (WO 2007014290), (15.89) N-methy1-2-(1- { [5-methy1-3-(trifluoromethyl)-1H-pyrazol-1-yl] acetyl} pip eridin-4-y1)-N- [(1S)-1,2,3,4-tetrahydronaphthalen-1 -yl] -1,3 -thiazo le-4-carb oxamide (922514-48-5) (WO 20070 14290), (15.90) pentyl { 64( {[(1-methy1-1H-tetrazol-5-yl)(phenyl)methylidene] amino} oxy)methyl]pyridin-2-y1} carbamate, (15.91) phenazine-l-carboxylic acid, (15.92) quinolin-8-ol (134-31-6), (15.93) quinolin-8-ol sulfate (2:1) (134-31-6) and (15.94) tert-butyl {6- [( { [(1-methyl-1H-tetrazol-5 -y1)(phenyl)methylene] amino}
oxy)methyl]pyridin-2-y1} carbamate.
(16) Further compounds, for example (16.1) 1-methy1-3 -(trifluoromethyl)-N- [2'-(trifluoromethyl)bipheny1-2-y1]-1H-pyrazole-4-c arb ox am i de , (1 6 .2 ) N-(4'-chlorobipheny1-2-y1)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide, (16.3) N-(2',4'-dichlorobipheny1-2-y1)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide, (16.4) 3 -(difluoromethyl)-1-methyl-N- [4'-(trifluoromethyl)bipheny1-2-yl] -1H-pyrazole-4-carboxamide, (16.5) N-(2',5'-difluorobipheny1-2-y1)-1-methyl-3 -(trifluoromethyl)-1H-pyrazole-4-carb oxamide, (16.6) 3 -(difluoromethyl)-1-methyl-N- [4'-(prop-1-yn-1-y1)biphenyl-2-yl] -1H-pyrazo le-4-c arb ox ami de (known from WO
2004/058723), (16.7) 5-fluoro-1,3 - dimethyl-N- [4'-(prop -1-yn-l-yl)biphenyl-2-yl] -1H-pyrazo le-4-c arb ox amid e (known from W 0 2004 /0 5 8 7 2 3 ) , (1 6. 8) 2-chloro-N-[4'-(prop-1-yn-1-y1)biphenyl-2-yl]pyridine-3-carboxamide (known from WO 2004/058723), (16.9) 3 -(difluoromethyl)-N- [4'43,3 -dimethylbut-l-yn-l-y1)biphenyl-2-y1]-1-methy1-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (16.10) N-[4'-(3,3-dimethylbut-1-yn-1-y1)biphenyl-2-yl] -5-fluoro-1,3 - dimethy1-1H-pyrazo le-4-c arb oxamide (known from WO 2004/058723), (16.11) 3 -(difluoromethyl)-N-(4'- ethynylbipheny1-2-y1)-1-methy1-1H-pyrazo le-4-carb oxamide (known from WO 2004/058723), (16.12) N-(4'-ethynylbipheny1-2-y1)-5-fluoro-1,3-dimethy1-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (16.13) 2-chloro-N-(4'-ethynylbipheny1-2-yl)pyridine-3-carboxamide (known from WO 2004/058723), (16.14) 2-chloro-N-[4'-(3,3 -dimethylbut-1-yn-1-y1)biphenyl-2-yl]pyridine-3 -c arb oxamide (known from WO 2004/058723), (16 . 15) 4-(difluoromethyl)-2-methyl-N- [4'-(trifluoromethyl)bipheny1-2-y1]-1,3-thiazole-5-carboxamide (known from WO 2004/058723), (16.16) 5-fluoro-N- [4'-(3 -hydroxy-3 -methylbut-l-yn-1 -yl)bipheny1-2-y1]-1,3-dimethy1-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (16.17) 2-chloro-N-[4'-(3-hydroxy-3-methylbut-1-yn-1-y1)biphenyl-2-yl]pyridine-3-c arb o x amide (known fr om WO
2004/058723), (16 .18) 3 -(difluoromethyl)-N- [4'-(3 -methoxy-3 -methylbut-l-yn-l-y1)biphenyl-2-yl] -1-methy1-1H-pyrazole-4-c arb o x ami de (known from WO 2004/058723), (16.19) 5-fluoro-N-[4'-(3-methoxy-3 -methylbut-1 -yn-1 -yl)b ipheny1-2-yl] -1,3 - dimethy1-1H-pyrazole-4-c arb ox ami de (known from WO 2004/058723), (16.20) 2-chloro-N-[4'-(3-methoxy-3-methylbut-1-yn-1-y1)biphenyl-2-yl]pyridine-3-carboxamide (known from WO 2004/058723), (16.21) (5-bromo-2-methoxy-4-methylpyridin-3-yl)(2,3,4-trimethoxy-6-methylphenyl)methanone (known from EP-A 1 559 320), (16.22) N-[2-(4- {[3-(4-chlorophenyl)prop-2-yn-l-yl] oxy} -3 -methoxyphenyl)ethyl] -N2-(methylsulfonyl)valinamide (220706-93-4), (16.23) 4-oxo-4-[(2-phenylethyl)amino]butanoic acid and (16.24) but-3-yn-l-y1 {6-[( {[(Z)-(1-methy1-1H-tetrazol-5 -y1)(phenyl)methylene] amino} oxy)methyl]pyridin-2-y1}
carbamate.
All named mixing partners of the classes (1) to (16) can, if their functional groups enable this, optionally form salts with suitable bases or acids.
In a preferred embodiment, the fungicides to be used in combination with the compound according to formula (I) fluopyram are selected from the following list:
Az oxys tr obin, Boscalid, Pe nflufen (N- [2- (1,3 -dimethylbutyl)phenyl] -5-fluoro-1,3-dimethy1-1H-pyrazole-4-carboxamide), Carbendazim, Carboxin, Fenamidone, Fludioxonil, Fluopicolide, Fluxapyrad, Fluoxastrobin, Fluquinconazole, Flutriafol, Ipconazole, Iprodione, Isopyrazam, Isotianil, Mefenoxam, Metalaxyl, Pencycuron, Penthiopyrad, Prochloraz, Prothioconazo le, Pyraclostrobin, Pyrimethanil, Sedaxane, Silthiopham, Tebuconazole, Thiram, Tolylfluanid, Triadimenol, Triazoxide, Trifloxystrobin, Triflumuron, Triticonazole, N-[9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-y1]-3 -(difluoromethyl)-1-methy1-1H-pyrazo le-4-c arb ox amide , 3 -D
ifluoromethyl-l-methy1-1H-pyrazo le-4-carboxylic acid [2-(2,4-dichloropheny1)-2-methoxy-l-methyl-ethyl]-amide.
In a preferred embodiment, the fungicides to be used in combination with the compound according to formula (I) fluopyram are selected from the following list:
Azoxystrobin, Boscalid, Penflufen (N42-(1,3-dimethylbutyl)pheny1]-5-fluoro-1,3-dimethy1-1H-pyrazole-4-carboxamide), Carbendazim, Fludioxonil, Fluopicolide, Fluxapyrad, Fluoxastrobin, Fluquinconazole, Ipconazole, Isopyrazam, Isotianil, Metalaxyl, Pencycuron, Penthiopyrad, Prochloraz, Prothioconazole, Pyraclostrobin, Pyrimethanil, Sedaxane, Tebuconazole, Triadimenol, Trifloxystrobin, Triticonazole, N-[9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-y1]-3-(difluoromethyl)-1-methy1-1H-pyrazole-4-c arb ox amid e, 3-Difluoromethyl- 1 -methy1-1H-pyrazole-4-carboxylic acid [2-(2,4-dichloropheny1)-2-methoxy-l-methyl-ethyl]-amide.
The following insecticides can be used in combination with the compound according to formula (I) fluopyram:
The active ingredients specified herein by their "common name" are known and described, for example, in the Pesticide Manual ("The Pesticide Manual", 14th Ed., British Crop Protection Council 2006) or can be searched in the internet (e.g. http://www.alanwood.net/pesticides).

(1) Acetylcholinesterase (AChE) inhibitors, for example carbamates, e.g. Alanycarb (II-1-1), Aldicarb (II-1-2), Bendiocarb (II-1-3), Benfuracarb (II-1-4), Butocarboxim (II-1-5), Butoxycarboxim (II-1-6), Carbaryl (II-1-7), Carbofuran (II-1-8), Carbosulfan (II-1-9), Ethiofencarb (II-1-10), Fenobucarb (11-1-1 1), Formetanate (II-1-12), Furathiocarb (II-1-13), Isoprocarb (II-1-14), Methiocarb (II-1-15), Methomyl (II-1-16), Metolcarb (II-1-17), Oxamyl (11-1-1 8), Pirimicarb (II-1-19), Propoxur (II-1-20), Thiodicarb (II-1-21), Thiofanox (II-1-22), Triazamate (II-1-23), Trimethacarb (II-1-24), XMC (II-1-25), and Xylylcarb (II-1-26); or organophosphates, e.g. Acephate (11-1-27), Azamethiphos (11-1-28), Azinphos-ethyl (11-1-29), Azinphos-methyl (II- 1 -30), Cadusafos (II- 1 -3 1), Chlorethoxyfos (II- 1 -32), Chlorfenvinphos (II- 1 -33), Chlormephos (11-1-34), Chlorpyrifos (11-1-35), Chlorpyrifos-methyl (11-1-36), Coumaphos (11-1-37), Cyanophos (11-1-38), Demeton-S-methyl (11-1-39), Diazinon (II-1-40), Dichlorvos/DDVP (II-1-41), Dicrotophos (II-1-42), Dimethoate (II-1-43), Dimethylvinphos (II-1-44), Disulfoton (II-1-45), EPN (II-1-46), Ethion (11-1-47), Ethoprophos (11-1-48), Famphur (11-1-49), Fenamiphos (II-1-50), Fenitrothion (II-1-5 1), Fenthion (11-1-52), Fosthiazate (11-1-53), Heptenophos (11-1-54), Imicyafos (11-1-55), Isofenphos (II-1-56), Isopropyl 0-(methoxyaminothio-phosphoryl) salicylate (11-1-57), Isoxathion (11-1-5 8), Malathion (11-1-59), Mec arb am (II-1-60), Methamidophos (11-1-6 1), Methidathion (11-1-62), Mevinphos (11-1-63), Monocrotophos (11-1-64), Naled (11-1-65), Omethoate (11-1-66), Oxydemeton-methyl (11-1-67), Parathion (11-1-68), Parathion-methyl (11-1-69), Phenthoate (II-1-70), Phorate (11-1-7 1), Phosalone (11-1-72), Phosmet (11-1-73), Phosphamidon (11-1-74), Phoxim (11-1-75), Pirimiphos-methyl (11-1-76), Profenofos (11-1-77), Propetamphos (11-1-78), Prothiofos (11-1-79), Pyraclofos (II-1-80), Pyridaphenthion (II-1-8 1), Quinalphos (11-1-82), Sulfotep (11-1-83), Tebupirimfos (11-1-84), Temephos (II-1-85), Terbufos (II-1-86), Tetrachlorvinphos (II-1-87), Thiometon (II-1-88), Triazophos (II-1-89), Triclorfon (II-1-90), and Vamidothion (II-1-91).
(2) GABA-gated chloride channel antagonists, for example cyclodiene organochlorines, e.g. Chlordane (II-2-1) and Endosulfan (11-2-2);
or phenylpyrazoles (fiproles), e.g. Ethiprole (11-2-3) and Fipronil (11-2-4).
(3) Sodium channel modulators / voltage-dependent sodium channel blockers, for example pyrethroids, e.g. Acrinathrin (II-3-1), Allethrin (II-3-2), d-cis-trans Allethrin (II-3-3), d-trans Allethrin (11-3-4), Bifenthrin (II-3-5), Bioallethrin (11-3-6), Bioallethrin S-cyclopentenyl isomer (11-3-7), Bioresmethrin (11-3-8), Cycloprothrin (11-3-9), Cyfluthrin (II-3-10), beta-Cyfluthrin (11-3-1 1), Cyhalothrin (II-3-12), lambda-Cyhalothrin (II-3-13), gamma-Cyhalothrin (11-3-14), Cypermethrin (II-3-1 5), alpha-Cypermethrin (11-3-16), beta-Cypermethrin (11-3-17), theta-Cypermethrin (11-3-18), zeta-Cypermethrin (11-3-1 9), Cyphenothrin [(1R)-trans isomers] (11-3-20), Deltamethrin (II-3-21), Empenthrin [(EZ)-(1R) isomers) (11-3-22), Esfenvalerate (11-3-23), Etofenprox (11-3-24), Fenpropathrin (11-3-25), Fenvalerate (11-3-26), Flucythrinate (11-3-27), Flumethrin (11-3-28), tau-Fluvalinate (11-3-29), Halfenprox (11-3-30), Imiprothrin (11-3-31), Kadethrin (11-3-32), Permethrin (11-3-33), Phenothrin [(1R)-trans isomer) (11-3-34), Prallethrin (11-3-35), Pyrethrine (pyrethrum) (11-3-36), Resmethrin (11-3-37), Silafluofen (11-3-38), Tefluthrin (11-3-39), Tetramethrin (II-3-40), Tetramethrin [(1R) isomers)] (11-3-4 1), Tralomethrin (11-3-42), and Transfluthrin (11-3-43); or DDT (11-3-44); or Methoxychlor (11-3-45).
(4) Nicotinic acetylcholine receptor (nAChR) agonists, for example neonicotinoids, e.g. Acetamiprid (II-4-1), Clothianidin (11-4-2), Dinotefuran (11-4-3), Imidacloprid (II-4-4), Nitenpyram (11-4-5), Thiacloprid (11-4-6), and Thiamethoxam (11-4-7); or Nicotine (11-4-8).
(5) Nicotinic acetylcholine receptor (nAChR) allosteric activators, for example spinosyns, e.g. Spinetoram (II-5-1) and Spinosad (11-5-2).
(6) Chloride channel activators, for example avermectins/milbemycins, e.g. Abamectin (11-6-1), Emamectin benzoate (11-6-2), Lepimectin (11-6-3), and Milbemectin (11-6-4).
(7) Juvenile hormone mimics, for example juvenile hormon analogues, e.g. Hydroprene (II-7-1), Kinoprene (11-7-2), and Methoprene (11-7-3); or Fenoxycarb (11-7-4); or Pyriproxyfen (11-7-5).
(8) Miscellaneous non-specific (multi-site) inhibitors, for example alkyl halides, e.g. Methyl bromide (II-8-1) and other alkyl halides; or Chloropicrin (11-8-2); or Sulfuryl fluoride (11-8-3); or Borax (11-8-4); or Tartar emetic (11-8-5).
(9) Selective homopteran feeding blockers, e.g. Pymetrozine (II-9-1); or Flonicamid (11-9-2).
(10) Mite growth inhibitors, e.g. Clofentezine (II-10-1), Hexythiazox (II-10-2), and Diflovidazin (11-1 0-3); or Etoxazo le (II- 1 0-4).

(11) Microbial disruptors of insect midgut membranes, e.g. Bacillus thuringiensis subspecies israelensis (II-11-1), Bacillus sphaericus (II-11-2), Bacillus thuringiensis subspecies aizawai (II-11-3), Bacillus thuringiensis subspecies kurstaki (II-11-4), Bacillus thuringiensis subspecies tenebrionis (II-11-5), and BT crop proteins: CrylAb, CrylAc, CrylFa, Cry2Ab, mCry3A, Cry3Ab, Cry3Bb, Cry34/35Abl (II-11-6).
(12) Inhibitors of mitochondrial ATP synthase, for example Diafenthiuron (II-12-1); or organotin miticides, e.g. Azocyclotin (11-12-2), Cyhexatin (11-12-3), and Fenbutatin oxide (11-12-4); or Propargite (II-12-5); or Tetradifon (II-12-6).
(13) Uncouplers of oxidative phoshorylation via disruption of the proton gradient, for example Chlorfenapyr (II-13-1), DNOC (II-13-2), and Sulfluramid (II-13-3).
(14) Nicotinic acetylcholine receptor (nAChR) channel blockers, for example Bensultap (II-14-1), Cartap hydrochloride (II-14-2), Thiocyclam (II-14-3), and Thiosultap-sodium (II-14-4).
(15) Inhibitors of chitin biosynthesis, type 0, for example Bistrifluron (II-15-1), Chlorfluazuron (II-15-2), Diflubenzuron (11-15-3), Flucycloxuron (11-15-4), Flufenoxuron (11-15-5), Hexaflumuron (11-15-6), Lufenuron (11-15-7), Novaluron (11-15-8), Noviflumuron (11-15-9), Teflubenzuron (II-15-10), and Triflumuron (II-15-11).
(16) Inhibitors of chitin biosynthesis, type 1, for example Buprofezin (II-16-1).
(17) Moulting disruptors, for example Cyromazine (II-17-1).
(18) Ecdysone receptor agonists, for example Chromafenozide (II-18-1), Halofenozide (11-18-2), Methoxyfenozide (II-18-3), and Tebufenozide (II-18-4).
(19) Octopamine receptor agonists, for example Amitraz (II-19-1).
(20) Mitochondrial complex III electron transport inhibitors, for example Hydramethylnon (II-20-1); or Acequinocyl (11-20-2); or Fluacrypyrim (11-20-3).
(21) Mitochondrial complex I electron transport inhibitors, for example METI acaricides, e.g. Fenazaquin (11-21-1), Fenpyroximate (11-21-2), Pyrimidifen (11-21-3), Pyridaben (11-21-4), Tebufenpyrad (11-21-5), and Tolfenpyrad (11-21-6); or Rotenone (Derris) (11-21-7).
(22) Voltage-dependent sodium channel blockers, e.g. Indoxacarb (11-22-1); or Metaflumizone (11-22-2).
(23) Inhibitors of acetyl CoA carboxylase, for example tetronic and tetramic acid derivatives, e.g. Spirodiclofen (11-23-1), Spiromesifen (11-23-2), and Spirotetramat (11-23-3).
(24) Mitochondrial complex IV electron transport inhibitors, for example phosphines, e.g. Aluminium phosphide (II-24-1), Calcium phosphide (11-24-2), Phosphine (11-24-3), and Zinc phosphide (11-24-4); or Cyanide (11-24-5).
(25) Mitochondrial complex II electron transport inhibitors, for example Cyenopyrafen (II-25-1).
(28) Ryanodine receptor modulators, for example diamides, e.g. Chlorantraniliprole (11-28-1) and Flubendiamide (11-28-2).
Further active ingredients with unknown or uncertain mode of action, for example Amidoflumet (11-29-1), Azadirachtin (11-29-2), Benclothiaz (11-29-3), Benzoximate (11-29-4), Bifenazate (11-29-5), Bromopropylate (11-29-6), Chinomethionat (11-29-7), Cryolite (11-29-8), Cyantraniliprole (Cyazypyr) (II-29-9), Cyflumetofen (11-29-10), Dicofol (11-29-11), Diflovidazin (11-29-12), Fluensulfone (11-29-13), Flufenerim (11-29-14), Flufiprole (11-29-15), Fluopyram (11-29-16), Fufenozide (11-29-17), Imidaclothiz (11-29-18), Iprodione (11-29-19), Meperfluthrin (11-29-20), Pyridalyl (11-29-21), Pyrifluquinazon (11-29-22), Tetramethylfluthrin (11-29-23), and iodomethane (11-29-24); furthermore products based on Bacillus firmus (including but not limited to strain CNCM 1-1582, such as, for example,VOTiVOTm, BioNem) (11-29-25) or one of the following known active compounds: 3-bromo-N- {2-bromo-4-chloro-6-[(1-cyclopropylethyl)carb amoyl] phenyl } -1 -(3 -chloropyridin-2-y1)-1H-pyrazole-5-carb oxamide (11-29-26) (known from W02005/077934), 4- { [(6-bromopyridin-3 -yl)methyl] (2-fluoro ethyl) amino } furan-2(5H)-one (11-29-27) (known from W02007/115644), 4- {[(6-fluoropyridin-3-yl)methyl](2,2-difluoroethyl)amino} furan-2(5H)-one (11-29-28) (known from W02007/115644), 4-{[(2-chloro-1,3-thiazol-5-yl)methyl](2-fluoroethyl)amino} furan-2(5H)-one (11-29-29) (known from W02007/115644), 4- {[(6-chlorpyridin-3-yl)methyl](2-fluoroethyl)amino} furan-2(5H)-o n e ( II-29-3 0) (known from W02007/115644), Flupyradifurone (11-29-31) (known from W02007/115644), 4-{[(6-chlor-5-fluoropyridin-3-yl)methyl] (methyl)amino} furan-2(5H)- one (11-29-32) (known from W02007/115643), 4- { [(5,6-dichloropyridin-3 -yl)methyl] (2-fluoro ethyl) amino } furan-2(5H)-o ne (II-29-33 ) (known from W02007/115646), 4- { [(6-chloro-5-fluoropyridin-3-yl)methyl](cyclopropyl)amino} furan-2 (5H)- one (II-29-34) (known from W02007/115643), 4- { [(6-chloropyridin-3-yl)methyl]
(cyclopropyl)amino} furan-2(5H)- one (11-29-35) (known from EP-A-0 539 588), 4- {[(6-chlorpyridin-3-yl)methyl](methyl)amino} furan-2(5H)-one (11-29-36) (known from EP-A-0 539 588), {[1-(6-chloropyridin-3-yl)ethyl](methyl)oxido-k4-sulfanylidene} cyanamide (11-29-3 7) (known fr o m W02007/149134) and its diastereomers {[(1R)-1-(6-chloropyridin-3-yl)ethyl](methyl)oxido-k4-sulfanylidene} cyanamide (A) (11-29-38), and { [(1 S)-1-(6-chloropyridin-3 -yl) ethyl] (methyl) oxido-k4-sulfanylidene}cyanamide (B) (11-29-39) (also known from W02007/149134) as well as Sulfoxaflor (II-29-40) (also known from W02007/149134) and its diastereomers [(R)-methyl(oxido){(1R)-1-[6-(trifluoromethyl)pyridin-3-yl] ethyl} 4.4 -sulfanylidene] cyanamide (Al) (11-29-41), and [(S)-methyl(oxido) { (1 S)-1 - [6-(trifluoromethyl)pyridin-3 -yl] ethyl} -24-sulfanylidene] cyanamide (A2) (11-29-42), referred to as group of diastereomers A (known from W02010/074747, W02010/074751), [(R)-methyl(oxido) { (1 S)-1 - [6-(trifluoromethyl)pyridin-3-yl] ethyl} -24-sulfanylidene] cyanamide (B1) (11-29-43), and [(S)-methyl(oxido){(1R)-1-[6-(trifluoromethyl)pyridin-3-yl]ethyl} -24-sulfanylidene]cyanamide (B2) (11-29-44), referred to as group of diastereomers B (also known from W02010/074747, WO 2 0 1 0/0 7 4 7 5 1), and 1 1-(4-chloro-2,6-dimethylpheny1)-12-hydroxy-1,4-dioxa-9-azadispiro [4.2.4.2] tetradec-11- en-10- one (11-29-45) (known from W02006/089633), 3 -(4'-fluoro-2,4-dimethylb ipheny1-3 -y1)-4-hydroxy-8- oxa-l-azaspiro [4. 5] dec-3 - en-2- one (11-29-46) (known from W02008/067911), 1- {2-fluoro-4-methyl-5- [(2,2,2-trifluorethyl)sulfinyl] phenyl } -3 -(trifluoromethyl)-1H-1,2,4-triazol-5-amine (11-29-47) (known from W02006/043635), [(3S,4aR,12R,12aS,12bS)-3-[(cyclopropylcarb onyl)oxy] -6,12- dihydroxy-4,12b- dimethyl-11- oxo-9-(pyridin-3 -y1)-1,3,4,4 a,5,6,6a,12,12 a,12b-decahydro-2H,11H-b enzo [f] pyrano [4,3 -b]
chromen-4-yl]methyl cyclopropanecarboxylate (11-29-48) (known from W02008/066153), 2-cyano-3-(difluoromethoxy)-N,N-dimethylbenzenesulfonamide (11-29-49) (known from W02006/056433), 2-cyano-3-(difluoromethoxy)-N-methylbenzenesulfonamide (11-29-50) (known from W02006/100288), 2-cyano-3-(difluoromethoxy)-N- ethylb enzenesulfonamide (11-29-51) (known from W02005/035486), 4-(difluoromethoxy)-N- ethyl-N-methy1-1,2-benzothiazol-3-amine 1,1-dioxide (11-29-52) (known from W02007/057407), N-[1-(2,3-dimethylpheny1)-2-(3,5-dimethylphenyl)ethyl]-4,5-dihydro-1,3-thiazol-2-amine (11-29-53) (known from W 02 0 0 8 /1 04 5 03 ), { 1'- [(2E)-3 -(4-chlorophenyl)prop-2- en-l-y1]-5-fluorosp iro [indole-3,4'-p ip eridin]-1(2H)-y1}(2-chloropyridin-4-yl)methanone (11-29-54) (known from W02003/106457), 3-(2,5-dimethylpheny1)-4-hydroxy-8-methoxy-1,8-diazaspiro [4.5] dec-3 - en-2- one (II-29-5 5 ) (known from W02009/049851), 3 -(2,5-dimethylpheny1)-8-methoxy-2- ox o-1,8- diazaspiro [4.5] dec-3 - en-4-y1 ethyl carbonate (11-29-56) (known from W02009/049851), 4-(but-2-yn-1-yloxy)-6-(3 ,5-dimethylpip eridin-1-y1)-5-fluoropyrimi dine (11-29-57) (known from W02004/099160), (2,2,3,3,4,4,5,5-octafluoropentyl)(3,3,3-trifluoropropyl)malononitrile (11-29-58) (known from WO 20 05 /063 0 94 ) , (2,2,3,3,4,4,5,5-octafluoropentyl)(3,3,4,4,4-pentafluorobutyl)malononitrile (11-29-59) (known from W 0 2 0 0 5 / 0 6 3 0 9 4 ) , 842-(cyclopropylmethoxy)-4-(trifluoromethyl)phenoxy]-346-(trifluoromethyl)pyridazin-3 -yl] -3 -azabicyclo [3.2.1] octane (11-29-60) (known from W02007/040280), 2- ethy1-7-methoxy-3 -methy1-6- [(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)oxy]quinolin-4-y1 methyl carbonate (11-29-61) (known from JP2008/110953), 2-ethy1-7-methoxy-3-methy1-6-[(2,2,3,3-tetrafluoro-2,3-dihydro-1,4-benzodioxin-6-y1)oxy]quinolin-4-y1 acetate ( II-29-6 2) (known from JP2008/110953), PF1364 (CAS-Reg.No. 1204776-60-2) (11-29-63) (known from JP2010/018586), 5-[5-(3,5-dichloropheny1)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-y1]-2-(1H-1,2,4-triazol-1-yl)b enzonitrile (11-29-64) (known from W02007/075459), 5- [5 -(2-chloropyridin-4-y1)-5 -(trifluoromethyl)-4,5 -dihydro- 1 ,2- oxazol-3 -yl] -2-( 1 H- 1 ,2,4-triazol-1 -yl)benzonitrile (11-29-65) (known from W02007/075459), 4-[5-(3,5-dichloropheny1)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-y1]-2-methyl-N-{2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl}benzamide (11-29-6 6) (known from W02005/085216), 4- { [(6-chloropyridin-3 -yl)methyl](cyclopropyl)amino} -1,3 -oxazol-2 (5 H)- one (11-29-6 7 ) , 4- { [(6-chloropyridin-3 -yl)methyl] (2,2- difluoro ethyl)amino } -1,3 -oxazol-2 (5H)- one (11-29-68), 4-{[(6-chloropyridin-3-yl)methyl](ethyl)amino} -1,3-oxazol-2(5H)-one (11-29-69), 4- {[(6-chloropyridin-3-yl)methyl](methyl)amino}-1,3-oxazol-2(5H)-one (11-29-70) (all known from W02010/005692), NNI-071 1 (11-29-71) (known from W02002/096882), 1-acetyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-methoxypropan-2-y1)-3 -is obutylphenyl] -N-is obutyry1-3 ,5 -dimethyl- 1 H-pyrazole-4-carb oxamide (11-29-72) (known from W02002/096882), methyl 2424 {[3-bromo-1-(3-chloropyridin-2-y1)-1H-pyrazol-5-yl]carbonyl} amino)-5-chloro-3-methylbenzoy1]-2-methylhydrazinecarboxylate (11-29-73) (known from W02005/085216), methyl 2- [2-( { [3 -bromo- 1 -(3 -chloropyridin-2-y1)- 1 H-pyrazol-5 -yl] carb onyl } amino)-5 -cyano-3 -methylbenzoyl] -2- ethylhydrazinecarb o xylate (11-29-74) (known from W02005/085216), methyl 2- [2-( { [3 -bromo- 1 -(3 -chloropyridin-2 -y1)- 1 H-pyrazol-5 -yl]
carbonyl} amino)-5-cyano-3 -methylbenzoy1]-2-methylhydrazinecarboxylate (11-29-75) (known from W02005/085216), methyl 2-[3 ,5 -dibromo-2 -( { [3 -bromo- 1 -(3 -chloropyridin-2 -y1)- 1 H-pyrazol-5 -yl] carb onyl } amino)b enzoyl] - 1 ,2-diethylhydrazinecarboxylate (11-29-76) (known from W02005/085216), methyl 2-[3,5-dibromo-2-({[3-bromo- 1 -(3 -chloropyridin-2-y1)- 1 H-pyrazol-5 -yl] carbonyl } amino)b enzoyl] -2- ethylhydrazinecarb oxylate (11-29-77) (known from W02005/085216), (5RS,7RS;5RS,7SR)-1-(6-chloro-3-pyridylmethyl)-1,2,3,5,6,7-hexahydro-7-methy1-8-nitro-5-propoxyimidazo[1,2-a] pyridine (11-29-78) (known from W02007/101369), 2- {6- [245 -fluoropyridin-3 -y1)-1,3 -thiazol-5-yl]pyridin-2-y1} pyrimidine (11-29-79) (known from W02010/006713 ), 2- {6- [2-(pyridin-3 -y1)-1,3 -thiazol-5-yl]pyridin-2-y1} pyrimidine (11-29-8 0) (known from W020 1 0/0 06 7 1 3), 1-(3-chloropyridin-2-y1)-N-[4-cyano-2-methy1-6-(methylcarb amoyl)phenyl] -3- { [5 -(trifluoromethyl)- 1 H-tetrazol- 1 -yl]
methyl } -1 H-pyrazo le-5 -carb oxamide (11-29-81) (known from W02010/069502), 1 -(3 -chloropyridin-2-y1)-N- [4-cyano-2-methy1-6-(methylcarbamoyl)pheny1]-3-{[5-(trifluoromethyl)-2H-tetrazol-2-yl]methy1}-1H-pyrazole-5-carboxamide (11-29-82) (known from W0201 0/069502), N-[2-(tert-butylcarbamoy1)-4-cyano-6-methylphenyl] -1 -(3 -chloropyridin-2-y1)-3 - { [5 -(trifluoromethyl)- 1 H-tetrazol- 1 -yl] methyl } -1 H-pyrazo le-5-carboxamide (11-29-83) (known from W02010/069502), N-[2-(tert-butylcarbamoy1)-4-cyano-6-methylphenyl] -1 -(3 -chloropyridin-2-y1)-3 - { [5 -(trifluoromethyl)-2H-tetrazol-2-yl]methyl } -1 H-pyrazo le-5-carboxamide (11-29-84) (known from W02010/069502), (1E)-N-[(6-chloropyridin-3-yl)methy1] -N'-cyano-N-(2,2-difluoroethyl)ethanimidamide (11-29-85) (known from W02008/009360), N-[2-(5-amino-1 ,3 ,4-thiadiazol-2-y1)-4-chloro-6-methylphenyl] -3 -bromo- 1 -(3 -chloropyridin-2-y1)- 1 H-pyrazo le-5 -carboxamide (11-29-86) (known from CN1 02057925), and methyl 243,5-dibromo-2-({[3-bromo-1-(3-chloropyridin-2-y1)- 1 H-pyrazol-5-yl] carbonyl } amino)b enzoyl] -2- ethyl- 1 -methylhydrazinecarboxylate (11-29-87) (known from W02011/049233).

In a preferred embodiment, the insecticide is selected from the group:
Clothianidin, imidacloprid, thiacloprid, thiamethoxam, acetamiprid, methiocarb, thiodicarb, beta-cyfluthrin, cyfluthrin, deltamethrin, tefluthrin, indoxacarb, spinosad, spinetoram, fipronil, ethiprole, emamectin-benzoate, avermectin, spirodiclofen, spiromesifen, spirotetramat, flubendiamide, (R),(S)-3-chloro-N1- {2-methyl-4- [1,2,2,2-tetrafluoro-1 -(trifluoromethyl) ethyl]
phenyl} -N2- (1-methy1-2 -methylsulphonylethyl)phthalamide, chlorantraniliprole (Rynaxypyr), or Cyantraniliprole (Cyazypyr), sulfoxaflor, Bacillus firmus strain CNCM I-1582.
In another preferred embodiment, the insecticides is selected from the group:
4- {[(6-brompyrid-3-yl)methyl] (2-fluorethyl) amino } furan-2(5H)- o n (known from WO
2007/115644), 4- { [(6-fluorpyrid-3 -4- { [(6-chlor-5-fluorpyrid-3-yl)methyl] (cyclopropyl)amino } furan-2(5H)- on (known from WO
2007/115643), 4- { [(6-chlorpyrid-3-yl)methyl] (cyclopropyl)amino } furan-2(5H)- on (known from EP-A-0 539 58 8), 4- {[(6-chlorpyrid-3-yl)methyl](methyl)amino} furan-2(5H)-on (known from EP-A-0 539 588).
Entomopathogenic nematode, Inoculants and Botanicals, can be used in combination with the compound according to formula (I) Fluopyram:
Examples of such bacteria to be used or employed according to the invention are:
(1.1) Agrobacterium radiobacter, (1.2) Bacillus acidocaldarius, (1.3) Bacillus acidoterrestris, (1.4) lentimorbus, (1.31) Bacillus lentus, (1.32) Bacillus licheniformis, (1.33) Bacillus maroccanus, (1.34) Bacillus megaterium (products known as BioArc), (1.35) Bacillus metiens, (1.36) Bacillus mycoides isolate J, (1.37) Bacillus natto, (1.38) Bacillus nematocida, (1.39) Bacillus nigrificans, (1.40) Bacillus nigrum, (1.41) Bacillus pantothenticus, (1.42) Bacillus popillae (products known as Cronox), (1.43) Bacillus psychrosaccharolyticus, (1.44) Bacillus pumilus, in particular strain GB34 (products known as Yield Shield ,) and strain QST2808 (products known as Sonata QST 2808 ), (1.45) Bacillus siamensis, (1.46) Bacillus smithii, (1.47) Bacillus sphaericus (products known as VectoLexe), (1.48) Bacillus subtilis, in particular strain GB03 (products known as Kodiak ) and strain QST
713 (products known as Serenade QST 713 ), or B. subtilis var. amyloliquefaciens strain FZB24 (products known as Taegre), (1.49) Bacillus thuringiensis, in particular B. thuringiensis var. israelensis (products known as VectoBac ) or B. thuringiensis subsp. aizawai strain ABTS-1857 (products known as XenTari ), or B.
thuringiensis subsp. kurstaki strain HD-1 (products known as Dipel ES) or B.
thuringiensis subsp.
tenebrionis strain NB 176 (products known as Novodor FC), or B. th. var.
aegyptii (products known as Agerin) , or B. th. var. colmeri (products known as TianBaoBTc) , or B. th.
var. darmstadiensis (products known as Baciturin, Kolepterin) , or B. th. var. dendrolimus (products known as Dendrobacillin) , or B. th. var. galleriae ((products known as Enterobactin) , or B. th. var. japonensis (products known as Buihunter) , or B.th. subsp. Morrisoni, or B. th. var. san diego, or B. th. subsp.
thuringiensis strain MPPL002, or B. th. var. thuringiensis (products known as Bikol) , or B. th. var 7216 (products known as Amactic, Pethian) , or B. th. var T36 (products known as Cahat), (1.50) Bacillus uniflagellatus, (1.51) Bradyrhizobium japonicum (Symbiont?, products known as SoySelect), (1.52) Brevibacillus brevis (formerly Bacillus brevis), in particular strains SS86-3, SS86-4, SS86-5, 2904, (1.53) Brevibacillus laterosporus (formerly Bacillus laterosporus), in particular strains 64, 1111, 1645, 1647, (1.54) Chromobacterium subtsugae, in particular strain PRAA4-1T
(products known as Gandevo), (1.55) Delftia acidovorans, in particular strain RAY209 (products known as BioBoose), (1.56) Lactobacillus acidophilus (products known as Fruitsan), (1.57) Lysobacter antibioticus, in particular strain 13-1 (cf. Biological Control 2008, 45, 288-296), (1.58) Lysobacter enzymogenes, in particular strain C3 (cf. J Nematol. 2006 June; 38(2): 233-239), (1.59) Paenibacillus alvei, in particular strains III3DT-1A, 1112E, 46C3, 2771 (Bacillus genetic stock center, Nov 2001), (1.60) Paenibacillus polymyxa, (1.61) Paenibacillus popilliae (formerly Bacillus popilliae), (1.62) Pantoea agglomerans, (1.63) Pasteuria penetrans (formerly Bacillus penetrans), products known as Pasteuria wettable powder, (1.64) Pasteuria usgae (products known as EconemTm), (1.65) Pectobacterium carotovorum (formerly Erwinia carotovora) products known as BioKeeper, (1.66) Pseudomonas aeruginosa (products known as Guiticid), (1.67) Pseudomonas aureofaciens (products known as Agate-25K), (1.68) Pseudomonas cepacia (formerly known as Burkholderia cepacia), in particular strains M54 or J82, (1.69) Pseudomonas chlororaphis, in particular strain MA 342 (products known as Cedomon), (1.70) Pseudomonas fluorescens (products known as Sudozone), (1.71) Pseudomonas proradix (products known as Proradie), (1.72) Pseudomonas putida (products known as Nematsid, (1.73) Pseudomonas resinovorans (products known as Solanacure), (1.74) Pseudomonas syringae (products known as Biosave), (1.75) Serratia entomophila (products known as invade), (1.76) Serratia marcescens, in particularstrain SRM (MTCC8708) or strain R35, (1.77) Streptomyces candidus (products known as BioAidTm), (1.78) Streptomyces colombiensis (products known as Mycoside), (1.79) Streptomyces galbus, in particular strain K61 (products known as Mycostop , cf. Crop Protection 2006, 25, 468-475) or strain QST 6047, (1.80) Streptomyces goshikiensis (products known as Safegro), (1.81) Streptomyces griseoviridis (products known as Mycostop , cf. Microbial db of Canada), (1.82) Streptomyces lavendulae (products known as Phytolavin-300, (1.83) Streptomyces lydicus, in particular strain WYCD108 (products known as ActinovateSP) or strain WYEC108 (products known as Actino-iron), (1.84) Streptomyces prasinus (cf. "Prasinons A and B: potent insecticides from Streptomyces prasinus"
Applied microbiology 1973 Nov), (1.85) Streptomyces rimosus (products known as Rhitovit), (1.86) Streptomyces saraceticus (products known as Clanda), (1.87) Streptomyces venezuelae, (1.88) Xanthomonas campestris (herbicidal activity), (1 . 8 9 ) Xenorhabdus luminescens, ( 1 . 9 0 ) and Xenorhabdus nematophila.
Biological control agents that are summarized under the term "fungi" or "yeasts" are:
(2.1) Ampelomyces quisqualis, in particular strain AQ 10 (product known as AQ
10 ), (2.2) Aureobasidium pullulans, in particular blastospores of strain DSM14940 or blastospores of strain DSM
14941 or mixtures thereof (product known as Blossom Protect ), (2.3) Aschersonia aleyrodes, (2.4) Aspergillus flavus, in particular strain NRRL 21882 (products known as Afla-Guard ), (2.5) Arthrobotiys superba (Corda 1839), (2.6) Beauveria bassiana, in particular strain ATCC 74040 (products known as Naturalis ) and strain GHA (products known as Mycotrol, BotaniGard), (2.7) Beauveria brongniartii (products known as Beaupro), (2.8) Candida oleophila, in particular strain 0 (products known as Nexy , Aspire), (2.9) Chaetomium cupreum (products known as Ketocin), (2.10) Cladosporium cladosporioides, in particular strain H39, (2.11) Conidiobolus obscurus, (2.12) Coniothyrium minitans, in particular strain CON/M/91-8 (products known as Contans ), (2.13) Dilophosphora alopecuri (products known as Twist Fungus ), (2.14) Entomophthora virulenta (products known as Vektor), (2.15) Fusarium oxysporum, in particular strain Fo47 (non-pathogenic) ( products known as Fusaclean), (2.16) Gliocladium catenulatum, in particular strain J1446 (products known as Prestop or Primastop), (2.17) Hirsutella thompsonii (products known as Mycohit or ABTEC), (2.18) Lagenidium giganteum (products known as Laginex by AgraQuest, Inc.), (2.19) Lecanicillium lecanii (formerly known as Verticillium lecanii), in particular conidia of strain KV01 (products known as Mycotal , Vertalee), (2.20) Metarhizium anisopliae, in particular strain F52 (products known as BIO 1020 or Met52), or M. a. var acridum (products known as Green Muscle), (2.21) Metarhizium flavoviride, (2.22) Metschnikovia fructicola, in particular the strain NRRL Y-30752 (product known as Shemer ), (2.23) Microsphaeropsis ochracea (products known as Microx ), (2.24) Mucor haemelis (product known as BioAvard), (2.25) Muscodor albus, in particular strain QST 20799 (products known as ArabesqueTM or AndanteTm), (2.26) Myrothecium verrucaria, in particular strain AARC-0255 (products known as DiTeraTm), (2.27) Nomuraea rileyi, in particular strains SA86101, GU87401, SR86151, CG128 and VA9101 (products known as Kongo ), (2.28) Ophiostoma piliferum, in particular strain D97 (products known as Sylvanex), (2.29) Paecilomyces fumosoreus, in particular strain apopka 97 (products known as PreFeRal), (2.30) Paecilomyces lilacinus, in particular spores of P.
lilacinus strain 251 (products known as BioAct , cf. Crop Protection 2008, 27, 352-361), (2.31) Paecilomyces variotii, in particular strain Q-09 (products known as Nemaquim), (2.32) Pandora delphacis, (2.33) Penicillium bilaii, in particular strain ATCC22348 (products known as JumpStart , PB-50, Provide), (2.34) Penicillium vermiculatum (products known as Vermiculen), (2.35) Phlebiopsis (=Phlebia = Peniophora) gigantea (products known as Rotstop), (2.36) Pichia anomala, in particular strain WRL-076, (2.37) Pochonia chlamydosporia, (2.38) Pseudozyma flocculosa, in particular strain PF-A22 UL (products known as Sporodex L), (2.39) Pythium oligandrum, in particular strain DV74 (products known as Polyversum), (2.40) Sporothrix insectorum (products known as Sporothrix), (2.41) Talaromyces flavus, (2.42) Trichoderma album (products known as Bio-Zeid), (2.43) Trichoderma asperellum, in particular strain ICC 012 (products known as Bioten ), (2.44) Trichoderma gamsii (formerly T. viride), in particular mycelial fragments,conidia &
chlamydospores of strain ICC080 (products known as Bioderma), (2.45) Trichoderma harmatum, (2.46) Trichoderma harzianum, in particular T harzianum T39 (products known as Trichodex ), (2.47) Trichoderma koningii (products known as Trikot-S Plus ), (2.48) Trichoderma lignorum (products known as Mycobac), (2.49) Trichoderma polysporum, in particular strain IMI 206039, (2.50) Trichoderma virens (formerly Gliocladium virens), (products known as SoilGard), (2.51) Tsukamurella paurometabola (products known as HeberNem0), (2.52) Ulocladium oudemansii (products known as Botry-Zen), (2.53) Verticillium albo-atrum, in particular strain WCS850, (2.54) Verticillium chlamydosporium (products known as Varsha), (2.55) Verticillium dahliae (products known as Dutch Trig), and (2.56) Zoophtora radicans.
Biological control agents that are summarized under the term "protozoas" are:
(3.1) Nosema locustae (products known as NoloBait), (3.2) Thelohania solenopsis and (3.3) Vairimorpha spp..
Biological control agents that are summarized under the term "viruses" are:
(4.1) Adoxophyes orana (summer fruit tortrix) granulosis virus (GV), (product known as BIOFA -Capex0), (4.2) Agrotis segetum (turnip moth) nuclear polyhedrosis virus (NPV), (4.3) Anticarsia gemmatalis (Woolly pyrol moth) mNPV (products known as Polygen), (4.4) Autographa californica (Alfalfa Looper ) mNPV (products known as VPN80 from Agricola El Sol), (4.5) Biston suppressaria (tea looper) NPV, (4.6) Bombyx mori (silkworm) NPV, (4.7) Cryptophlebia leucotreta (false codling moth) GV (products known as Cryptex), (4.8) Cydia pomonella (Codling moth) granulosis virus (GV) (product known as Madex Plus), (4.9) Dendrolimus punctatus (Masson pine moth) CPV, (5.0) Helicoverpa armigera NPV (product known as AgBiTech - ViVUS Max), (5.1) Helicoverpa (previously Hetiothis) zea (corn earworm) NPV (products known as Elcar), (5.2) Leucoma salicis (satin moth) NPV, (5.3) Lymantria dispar (gypsy moth) NPV (products known as Gypcheck), (5.4) Neodiprion abietis (balsam-fir sawfly) NPV (products known as Abietiv), (5.5) Neodiprion lecontei (red-headed pinesawfly) NPV (products known as Lecontvirus), (5.6) Neodiprion sertifer (Pine sawfly) NPV
(products known as Neocheck-S), (5.7) Orgyia pseudotsugata (Douglas-fir tussock moth) NPV
(products known as Virtuss), (5.8) Phthorimaea opercutella (tobacco leaf miner) GV (products known as Matapol), (5.9) Pieris rapae (small white) GV, (6.0) Plutella xylostella (diamondback moth) GV
(products known as Plutec), (6.1) Spodoptera albula (gray-streaked armywom moth) mNPV (products known as VPN 82), (6.2) Spodoptera exempta (true armyworm) mNPV (products known as Spodec), (6.3) Spodoptera exigua (sugarbeet armyworm) mNPV (products known as Spexit from Andermatt Biocontrol), (6.4) Spodoptera frugiperda (fall armyworm) mNPV (products known as Baculovirus VPN), (6.5) Spodoptera littoratis (tobacco cutworm) NPV (procucts known as Spodoptrin from NPP
Calliope France), and (6.6) Spodoptera litura (oriental leafworm moth) NPV
(products known as Littovir).
Biological control agents that are summarized under the term "entomopathogenic nematodes" are:
(5.1) Abbreviata caucasica, (5.2) Acuaria spp., (5.3) Agamermis decaudata, (5.4) Allantonema spp., (5.5) Amphimermis spp., (5.6) Beddingia (= Deladenus) siridicola, (5.7) Bovienema spp., (5.7) Cameronia spp., (5.8) Chitwoodiella ovofilamenta, (5.9) Contortylenchus spp., (5.10) Culicimermis spp., (5.11) Diplotriaena spp., (5.12) Empidomermis spp., (5.13) Filipjevimermis leipsandra, (5.14) Gastromermis spp., (5.15) Gongylonema spp., (5.16) Gynopoecilia pseudovipara, (5.17) Heterorhabditis spp., in particular Heterorhabditis bacteriophora (products known as B-Green), or Heterorhabditis baujardi, or Heterorhabditis hetiothidis (products known as N e m at o n) , or Heterorhabditis indica, Heterorhabditis marelatus, Heterorhabditis megidis, Heterorhabditis zealandica, (5.18) Hexamermis spp., (5.19) Hydromermis spp., (5.20) Isomermis spp., (5.21) Limnomermis spp., (5.22) Maupasina weissi, (5.23) Mermis nigrescens, (5.24) Mesomermis spp., (5.25) Neomesomermis spp., (5.26) Neoparasitylenchus rugulosi, (5.27) Octomyomermis spp., (5.28) Parasitaphelenchus spp., (5.29) Parasitorhabditis spp., (5.30) Parasitylenchus spp., (5.31) Perutilimermis culicis, (5.32) Phasmarhabditis hermaphrodita, (5.33) Physaloptera spp., (5.34) Protrellatus spp., (5.35) Pterygodermatites spp., (5.36) Romanomermis spp., (5.37) Seuratum cadarachense, (5.38) Sphaerulariopsis spp., (5.39) Spirura guianensis, (5.40) Steinernema spp. (= Neoaplectana spp.), in particular Steinernema carpocapsae (products known as Biocontrol), or Steinernema feltiae (= Neoaplectana carpocapsae), (products known as Nemasys0), or Steinernema glaseri (procucts known as Biotopia), or Steinernema kraussei (products known as Larvesure), or Steinernema riobrave (products known as Biovector), or Steinernema scapterisci (products known as Nematac S), or Steinernema scarabaei, or Steinernema siamkayai, (5.41) Strelkovimermis peterseni, (5.42) Subulura spp., (5.43) Sulphuretylenchus elongatus, and (5.44) Tetrameres spp..
Biological control agents that are summarized under the term "inoculants" are:
(C6.1) Agro bacterium spp., (C6.2) Azorhizobium caulinodans, (C6.3) Azospirillum spp., (C6.4) Azotobacter spp., (C6.5) Bradyrhizobium spp., (C6.6) Burkholderia spp., in particular Burkholderia cepacia (formerly Pseudomonas cepacia), (C6.7) Gigaspora spp., in particular Gigaspora margarita, or Gigaspora monosporum, (C6.8) Glomus spp., in particular Glomus aggregatum, or Glomus brasilianum, or Glomus clarum, or Glomus deserticola, or Glomus etunicatum, or Glomus intraradices, or Glomus monosporus, or Glomus mosseae, (C6.9) Laccaria spp., in particular Laccaria bicolor, or Laccaria laccata, (C6.10) Lactobacillus buchneri, (C6.11) Paraglomus spp., (C6.12) Pisolithus tinctorus, (C6.13) Pseudomonas spp., (C6.14) Rhizobium spp., in particular Rhizobium fredii, or Rhizobium leguminosarum, or Rhizobium loti, or Rhizobium meliloti, or Rhizobium trifolii, or Rhizobium tropici, (C.6.15) Rhizopogon amylopogon, or Rhizopogon fulvigleba, or Rhizopogon luteolus, or Rhizopogon tinctorus, or Rhizopogon villosullus, or (C.6.16) Scleroderma spp., in particular Scleroderma cepa, or Scleroderma citrinum, (C6.17) Suillus spp., in particular Suillus granulates, or Suillus punctatapies and (C6.18) Streptomyces spp..
Biological control agents that are summarized under the term "Botanicals" are:
(C7.1) Thymol, extracted e. g. from thyme (thymus vulgaris), (C7.2) Neem tree (Azadirachta indica) oil, and therein Azadirachtin, (C7.3) Pyrethrum, an extract made from the dried flower heads of different species of the genus Tanacetum, and therein Pyrethrins (the active components of the extract), (C7.4) extract of Cassia nigricans, (C7.5) wood extract of Quassia amara (bitterwood), (C7.6) Rotenon, an extract from the roots and stems of several tropical and subtropical plant species, especially those belonging to the genera Lonchocarpus and Derris, (C7.7) extract ofAllium sativum (garlic), (C7.8) Quillaja extract, made from the concentrated purified extract of the outer cambium layer of the Quillaja Saponaria Molina tree, (C7.9) Sabadilla (Sabadilla= Schoenocaulon officinale) seeds, in particular Veratrin (extracted from the seeds), (C7.10) Ryania, an extract made from the ground stems of Ryania speciosa, in particular Ryanodine (the active component of the extract), (C7.11) extract of Viscum album (mistletoe), (C7.12) extract of Tanacetum vulgare (tansy), (C7.13) extract of Artemisia absinthium (wormwood), (C7.14) extract of Urtica dioica (stinging nettle), (C7.15) extract of Symphytum officinale (common comfrey), (C7.16) extract of Tropaeulum majus (monks cress), (C7.17) leaves and bark of Quercus (oak tree) (C7.18) Yellow mustard powder, (C7.19) oil of the seeds of Chenopodium anthelminticum (wormseed goosefoot), (C7.20) dried leaves of Dryopteris filix-mas (male fern), (C7.21) bark of Celastrus angulatus (Chinese bittersweet), (C7.22) extract of Equisetum arvense (field horsetail), (C7.23) Chitin.
Biological control agents that are "Products produced by microorganisms including proteins or secondary metabolites" are:
(B8.1) Harpin (isolated by Erwinia amylovora, products known as Harp-N-TekTm, Messenger , EmployTM, ProActTm).
In a preferred embodiment, the biological control agents are selected from the group:
(1.12) Bacillus amyloliquefaciens, in particular strain IN937a, or strain FZB42 (product known as RhizoVitar), or strain B3, (1.17) Bacillus cereus (synonyms: Bacillus endorhythmos, Bacillus medusa), in particular spores of B. cereus strain CNCM 1-1562 (cf. US 6,406,690), (1.34) Bacillus megaterium (products known as BioArc), (1.44) Bacillus pumilus, in particular strain GB34 (products known as Yield Shield ,) and strain Q5T2808 (products known as Sonata QST 2808 ), (1.47) Bacillus sphaericus (products known as VectoLexe), (1.48) Bacillus subtilis, in particular strain GB03 (products known as Kodiak ) and strain QST 713 (products known as Serenade QST 713 ), or B.
subtilis var.
amyloliquefaciens strain FZB24 (products known as Taegre), (1.49) Bacillus thuringiensis, in particular B. thuringiensis var. israelensis (products known as VectoBac ) or B. thuringiensis subsp.
aizawai strain ABTS-1857 (products known as XenTari ), or B. thuringiensis subsp. kurstaki strain HD-1 (products known as Dipel ES) or B. thuringiensis subsp. tenebrionis strain NB 176 (products known as Novodor FC), or B. th. var. aegyptii (products known as Agerin) , or B.
th. var. colmeri (products known as TianBaoBTc) , or B. th. var. darmstadiensis (products known as Baciturin, Kolepterin) , or B.
th. var. dendrolimus (products known as Dendrobacillin) , or B. th. var.
galleriae ((products known as Enterobactin) , or B. th. var. japonensis (products known as Buihunter) , or B. th. subsp. Morrisoni, or B.
th. var. san diego, or B. th. subsp. thuringiensis strain MPPL002, or B. th.
var. thuringiensis (products known as Bikol) , or B. th. var 7216 (products known as Amactic, Pethian) , or B. th. var T36 (products known as Cahat), (1.55) Delftia acidovorans, in particular strain RAY209 (products known as BioBoose), (1.56) Lactobacillus acidophilus (products known as Fruitsan), (1.57) Lysobacter antibioticus, in particular strain 13-1 (cf. Biological Control 2008, 45, 288-296), (1.58) Lysobacter enzymogenes, in particular strain C3 (cf. J Nematol. 2006 June; 38(2): 233-239), (1.59) Paenibacillus alvei, in particular strains III3DT-1A, 1112E, 46C3, 2771 (Bacillus genetic stock center, Nov 2001), (1.70) Pseudomonas fluorescens (products known as Sudozone), (1.71) Pseudomonas proradix (products known as Proradie), (1.72) Pseudomonas putida (products known as Nematsid, (1.73) Pseudomonas resinovorans (products known as Solanacure), (1.74) Pseudomonas syringae (products known as Biosave), (1.75) Serratia entomophila (products known as invade), (1.76) Serratia marcescens, in particularstrain SRM (MTCC8708) or strain R35, (1.77) Streptomyces candidus (products known as BioAidrm), (1.78) Streptomyces colombiensis (products known as Mycoside), (1.79) Streptomyces galbus, in particular strain K61 (products known as Mycostop , cf. Crop Protection 2006, 25, 468-475) or strain QST 6047, When treating the seed, care must generally be taken that the amount of the composition according to the invention applied to the seed and/or the amount of further additives is chosen in such a way that the germination of the seed is not adversely affected, or that the resulting plant is not damaged. This must be borne in mind in particular in the case of active compounds which may have phytotoxic effects at certain application rates.
According to the invention all plants and plant parts can be treated. By plants is meant all plants and plant populations such as desirable and undesirable wild plants, cultivars and plant varieties (whether or not protectable by plant variety or plant breeder's rights). Cultivars and plant varieties can be plants obtained by conventional propagation and breeding methods which can be assisted or supplemented by one or more biotechnological methods such as by use of double haploids, protoplast fusion, random and directed mutagenesis, molecular or genetic markers or by bioengineering and genetic engineering methods. By plant parts is meant all above ground and below ground parts and organs of plants such as shoot, leaf, blossom and root, whereby for example leaves, needles, stems, branches, blossoms, fruiting bodies, fruits and seed as well as roots, tubers, corms and rhizomes are listed. Crops and vegetative and generative propagating material, for example cuttings, corms, rhizomes, tubers, runners and seeds also belong to plant parts.
Among the plants that can be protected by the method according to the invention, mention may be made of major field crops like corn, soybean, cotton, Brassica oilseeds such as Brassica napus (e.g. canola), Brassica rapa, B. juncea (e.g. mustard) and Brassica carinata, rice, wheat, sugarbeet, sugarcane, oats, rye, barley, millet, triticale, flax, vine and various fruits and vegetables of various botanical taxa such as Rosaceae sp. (for instance pip fruit such as apples and pears, but also stone fruit such as apricots, cherries, almonds and peaches, berry fruits such as strawberries), Ribesioidae sp., Juglandaceae sp., Betulaceae sp., Anacardiaceae sp., Fagaceae sp., Moraceae sp., Oleaceae sp., Actinidaceae sp., Lauraceae sp., Musaceae sp. (for instance banana trees and plantings), Rubiaceae sp. (for instance coffee), Theaceae sp., Sterculiceae sp., Rutaceae sp. (for instance lemons, oranges and grapefruit) ;
Solanaceae sp. (for instance tomatoes, potatoes, peppers, eggplant), Liliaceae sp., Compositiae sp. (for instance lettuce, artichoke and chicory - including root chicory, endive or common chicory), Umbelliferae sp. (for instance carrot, parsley, celery and celeriac), Cucurbitaceae sp. (for instance cucumber ¨ including pickling cucumber, squash, watermelon, gourds and melons), Alliaceae sp. (for instance onions and leek), Cruciferae sp. (for instance white cabbage, red cabbage, broccoli, cauliflower, brussel sprouts, pak choi, kohlrabi, radish, horseradish, cress, Chinese cabbage), Leguminosae sp. (for instance peanuts, peas and beans beans - such as climbing beans and broad beans), Chenopodiaceae sp.
(for instance mangold, spinach beet, spinach, beetroots), Malvaceae (for instance okra), Asparagaceae (for instance asparagus); horticultural and forest crops; ornamental plants;
as well as genetically modified homologues of these crops.
The method of treatment according to the invention can be used in the treatment of genetically modified organisms (GM0s), e.g. plants or seeds. Genetically modified plants (or transgenic plants) are plants of which a heterologous gene has been stably integrated into genome. The expression "heterologous gene"
essentially means a gene which is provided or assembled outside the plant and when introduced in the nuclear, chloroplastic or mitochondrial genome gives the transformed plant new or improved agronomic or other properties by expressing a protein or polypeptide of interest or by downregulating or silencing other gene(s) which are present in the plant (using for example, antisense technology, cosuppression technology or RNA interference ¨ RNAi - technology). A heterologous gene that is located in the genome is also called a transgene. A transgene that is defined by its particular location in the plant genome is called a transformation or transgenic event.
Depending on the plant species or plant cultivars, their location and growth conditions (soils, climate, vegetation period, diet), the treatment according to the invention may also result in superadditive ("synergistic") effects. Thus, for example, reduced application rates and/or a widening of the activity spectrum and/or an increase in the activity of the active compounds and compositions which can be used according to the invention, better plant growth, increased tolerance to high or low temperatures, increased tolerance to drought or to water or soil salt content, increased flowering performance, easier harvesting, accelerated maturation, higher harvest yields, bigger fruits, larger plant height, greener leaf color, earlier flowering, higher quality and/or a higher nutritional value of the harvested products, higher sugar concentration within the fruits, better storage stability and/or processability of the harvested products are possible, which exceed the effects which were actually to be expected.
At certain application rates, the active compound combinations according to the invention may also have a strengthening effect in plants. Accordingly, they are also suitable for mobilizing the defense system of the plant against attack by unwanted microorganisms. This may, if appropriate, be one of the reasons of the enhanced activity of the combinations according to the invention, for example against fungi. Plant-strengthening (resistance-inducing) substances are to be understood as meaning, in the present context, those substances or combinations of substances which are capable of stimulating the defense system of plants in such a way that, when subsequently inoculated with unwanted microorganisms, the treated plants display a substantial degree of resistance to these microorganisms. In the present case, unwanted microorganisms are to be understood as meaning phytopathogenic fungi, bacteria and viruses. Thus, the
- 26 -substances according to the invention can be employed for protecting plants against attack by the abovementioned pathogens within a certain period of time after the treatment.
The period of time within which protection is effected generally extends from 1 to 30 days, preferably 1 to 14 days, after the treatment of the plants with the active compounds.
Plants and plant cultivars which are preferably to be treated according to the invention include all plants which have genetic material which impart particularly advantageous, useful traits to these plants (whether obtained by breeding and/or biotechnological means).
Plants and plant cultivars which are also preferably to be treated according to the invention are resistant against one or more biotic stresses, i.e. said plants show a better defense against animal and microbial pests, such as against nematodes, insects, mites, phytopathogenic fungi, bacteria, viruses and/or viroids.
Examples of nematode resistant plants are described in e.g. US Patent Application Nos 11/765,491, 11/765,494, 10/926,819, 10/782,020, 12/032,479, 10/783,417, 10/782,096, 11/657,964, 12/192,904, 11/396,808, 12/166,253, 12/166,239, 12/166,124, 12/166,209, 11/762,886, 12/364,335, 11/763,947, 12/252,453, 12/209,354, 12/491,396 and 12/497,221.
Plants and plant cultivars which may also be treated according to the invention are those plants which are resistant to one or more abiotic stresses. Abiotic stress conditions may include, for example, drought, cold temperature exposure, heat exposure, osmotic stress, flooding, increased soil salinity, increased mineral exposure, ozone exposure, high light exposure, limited availability of nitrogen nutrients, limited availability of phosphorus nutrients, shade avoidance.
Plants and plant cultivars which may also be treated according to the invention, are those plants characterized by enhanced yield characteristics. Increased yield in said plants can be the result of, for example, improved plant physiology, growth and development, such as water use efficiency, water retention efficiency, improved nitrogen use, enhanced carbon assimilation, improved photosynthesis, increased germination efficiency and accelerated maturation. Yield can furthermore be affected by improved plant architecture (under stress and non-stress conditions), including but not limited to, early flowering, flowering control for hybrid seed production, seedling vigor, plant size, internode number and distance, root growth, seed size, fruit size, pod size, pod or ear number, seed number per pod or ear, seed mass, enhanced seed filling, reduced seed dispersal, reduced pod dehiscence and lodging resistance. Further yield traits include seed composition, such as carbohydrate content, protein content, oil content and composition, nutritional value, reduction in anti-nutritional compounds, improved processability and better storage stability.
Plants that may be treated according to the invention are hybrid plants that already express the characteristic of heterosis or hybrid vigor which results in generally higher yield, vigor, health and resistance towards biotic and abiotic stresses. Such plants are typically made by crossing an inbred male-
- 27 -sterile parent line (the female parent) with another inbred male-fertile parent line (the male parent).
Hybrid seed is typically harvested from the male sterile plants and sold to growers. Male sterile plants can sometimes (e.g. in corn) be produced by detasseling, i.e. the mechanical removal of the male reproductive organs (or males flowers) but, more typically, male sterility is the result of genetic determinants in the plant genome. In that case, and especially when seed is the desired product to be harvested from the hybrid plants it is typically useful to ensure that male fertility in the hybrid plants is fully restored. This can be accomplished by ensuring that the male parents have appropriate fertility restorer genes which are capable of restoring the male fertility in hybrid plants that contain the genetic determinants responsible for male-sterility. Genetic determinants for male sterility may be located in the cytoplasm. Examples of cytoplasmic male sterility (CMS) were for instance described in Brassica species. However, genetic determinants for male sterility can also be located in the nuclear genome.
Male sterile plants can also be obtained by plant biotechnology methods such as genetic engineering. A
particularly useful means of obtaining male-sterile plants is described in WO
89/10396 in which, for example, a ribonuclease such as barnase is selectively expressed in the tapetum cells in the stamens.
Fertility can then be restored by expression in the tapetum cells of a ribonuclease inhibitor such as barstar.
Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may be treated according to the invention are herbicide-tolerant plants, i.e.
plants made tolerant to one or more given herbicides. Such plants can be obtained either by genetic transformation, or by selection of plants containing a mutation imparting such herbicide tolerance.
Herbicide-resistant plants are for example glyphosate-tolerant plants, i.e.
plants made tolerant to the herbicide glyphosate or salts thereof Plants can be made tolerant to glyphosate through different means.
For example, glyphosate-tolerant plants can be obtained by transforming the plant with a gene encoding the enzyme 5-enolpyruvylshilcimate-3-phosphate synthase (EPSPS). Examples of such EPSPS genes are the AroA gene (mutant CT7) of the bacterium Salmonella typhimurium (Comai et al., 1983, Science 221, 370-371), the CP4 gene of the bacterium Agro bacterium sp. (Barry et al., 1992, Curr. Topics Plant Physiol. 7, 139-145), the genes encoding a Petunia EPSPS (Shah et al., 1986, Science 233, 478-481), a Tomato EPSPS (Gasser et al., 1988, J. Biol. Chem. 263, 4280-4289), or an Eleusine EPSPS (WO
01/66704). It can also be a mutated EPSPS. Glyphosate-tolerant plants can also be obtained by expressing a gene that encodes a glyphosate oxido-reductase enzyme. Glyphosate-tolerant plants can also be obtained by expressing a gene that encodes a glyphosate acetyl transferase enzyme. Glyphosate-tolerant plants can also be obtained by selecting plants containing naturally-occurring mutations of the above-mentioned genes. Plants expressing EPSPS genes that confer glyphosate tolerance are described.
Plants comprising other genes that confer glyphosate tolerance, such as decarboxylase genes, are described.
- 28 -Other herbicide resistant plants are for example plants that are made tolerant to herbicides inhibiting the enzyme glutamine synthase, such as bialaphos, phosphinothricin or glufosinate.
Such plants can be obtained by expressing an enzyme detoxifying the herbicide or a mutant glutamine synthase enzyme that is resistant to inhibition. One such efficient detoxifying enzyme is an enzyme encoding a phosphinothricin acetyltransferase (such as the bar or pat protein from Streptomyces species). Plants expressing an exogenous phosphinothricin acetyltransferase are described.
Further herbicide-tolerant plants are also plants that are made tolerant to the herbicides inhibiting the enzyme hydroxyphenylpyruvatedioxygenase (HPPD).
Hydroxyphenylpyruvatedioxygenases HPPD is an are enzyme that catalyze the reaction in which para-hydroxyphenylpyruvate (HPP) is transformed into homogentisate. Plants tolerant to HPPD-inhibitors can be transformed with a gene encoding a naturally-occurring resistant HPPD enzyme, or a gene encoding a mutated or chimeric HPPD
enzyme as described in WO 96/38567, WO 99/24585, and WO 99/24586, WO 2009/144079, WO 2002/046387, or US
6,768,044. Tolerance to HPPD-inhibitors can also be obtained by transforming plants with genes encoding certain enzymes enabling the formation of homogentisate despite the inhibition of the native HPPD enzyme by the HPPD-inhibitor. Such plants and genes are described in WO
99/34008 and WO
02/36787. Tolerance of plants to HPPD inhibitors can also be improved by transforming plants with a gene encoding an enzyme having prephenate deshydrogenase (PDH) activity in addition to a gene encoding an HPPD-tolerant enzyme, as described in WO 2004/024928. Further, plants can be made more tolerant to HPPD-inhibitor herbicides by adding into their genome a gene encoding an enzyme capable of metabolizing or degrading HPPD inhibitors, such as the CYP450 enzymes shown in WO
2007/103567 and WO 2008/150473.
Still further herbicide resistant plants are plants that are made tolerant to acetolactate synthase (ALS) inhibitors. Known AL S-inhibitors include, for example, sulfonylurea, imidazolinone, triazolopyrimidines, pryimidinyoxy(thio)benzoates, and/or sulfonylaminocarbonyltriazolinone herbicides. Different mutations in the ALS enzyme (also known as acetohydroxyacid synthase, AHAS) are known to confer tolerance to different herbicides and groups of herbicides, as described for example in Tranel and Wright (2002, Weed Science 50:700-712). The production of sulfonylurea-tolerant plants and imidazolinone-tolerant plants is described. Other imidazolinone-tolerant plants are also described.
Further sulfonylurea- and imidazolinone-tolerant plants are also described.
Other plants tolerant to imidazolinone and/or sulfonylurea can be obtained by induced mutagenesis, selection in cell cultures in the presence of the herbicide or mutation breeding as described for example for soybeans in U.S. Patent 5,084,082, for rice in WO 97/41218, for sugar beet in U.S. Patent 5,773,702 and WO 99/057965, for lettuce in U.S. Patent 5,198,599, or for sunflower in WO
01/065922.
Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are insect-resistant transgenic plants, i.e. plants made
- 29 -resistant to attack by certain target insects. Such plants can be obtained by genetic transformation, or by selection of plants containing a mutation imparting such insect resistance.
An "insect-resistant transgenic plant", as used herein, includes any plant containing at least one transgene comprising a coding sequence encoding:
1) an insecticidal crystal protein from Bacillus thuringiensis or an insecticidal portion thereof, such as the insecticidal crystal proteins listed by Crickmore et al. (1998, Microbiology and Molecular Biology Reviews, 62: 807-813), updated by Crickmore et al. (2005) at the Bacillus thuringiensis toxin nomenclature, online at:
http ://www. lifesci. sus s ex. ac.uk/Home/Neil_Crickmore/Bt/), or insecticidal portions thereof, e.g., proteins of the Cry protein classes Cryl Ab, CrylAc, Cry1B, Cry1C, CrylD, Cry1F, Cry2Ab, Cry3Aa, or Cry3Bb or insecticidal portions thereof (e.g. EP 1999141_and WO
2007/107302), or such proteins encoded by synthetic genes as e.g. described in US Patent Application No 12/249,016; or 2) a crystal protein from Bacillus thuringiensis or a portion thereof which is insecticidal in the presence of a second other crystal protein from Bacillus thuringiensis or a portion thereof, such as the binary toxin made up of the Cry34 and Cry35 crystal proteins (Moellenbeck et al.
2001, Nat. Biotechnol. 19:
668-72; Schnepf et al. 2006, Applied Environm. Microbiol. 71, 1765-1774) or the binary toxin made up of the Cryl A or Cryl F proteins and the Cry2Aa or Cry2Ab or Cry2Ae proteins (US Patent Appl. No.
12/214,022 and EP 08010791.5); or 3) a hybrid insecticidal protein comprising parts of different insecticidal crystal proteins from Bacillus thuringiensis, such as a hybrid of the proteins of 1) above or a hybrid of the proteins of 2) above, e.g., the Cry1A.105 protein produced by corn event M0N89034 (WO 2007/027777); or 4) a protein of any one of 1) to 3) above wherein some, particularly 1 to 10, amino acids have been replaced by another amino acid to obtain a higher insecticidal activity to a target insect species, and/or to expand the range of target insect species affected, and/or because of changes introduced into the encoding DNA during cloning or transformation, such as the Cry3Bb1 protein in corn events M0N863 or M0N88017, or the Cry3A protein in corn event MIR604; or 5) an insecticidal secreted protein from Bacillus thuringiensis or Bacillus cereus, or an insecticidal portion thereof, such as the vegetative insecticidal (VIP) proteins listed at:
http ://www. life sci. sus s ex. ac.uk/home/Neil_Crickmore/Bt/vip.html, e.g., proteins from the VIP3Aa protein class; or 6) a secreted protein from Bacillus thuringiensis or Bacillus cereus which is insecticidal in the presence of a second secreted protein from Bacillus thuringiensis or B. cereus, such as the binary toxin made up of the VIP1A and VIP2A proteins (WO 94/21795); or
- 30 -7) a hybrid insecticidal protein comprising parts from different secreted proteins from Bacillus thuringiensis or Bacillus cereus, such as a hybrid of the proteins in 1) above or a hybrid of the proteins in 2) above; or 8) a protein of any one of 5) to 7) above wherein some, particularly 1 to 10, amino acids have been replaced by another amino acid to obtain a higher insecticidal activity to a target insect species, and/or to expand the range of target insect species affected, and/or because of changes introduced into the encoding DNA during cloning or transformation (while still encoding an insecticidal protein), such as the VIP3Aa protein in cotton event COT102; or 9) a secreted protein from Bacillus thuringiensis or Bacillus cereus which is insecticidal in the presence of a crystal protein from Bacillus thuringiensis, such as the binary toxin made up of VIP3 and CrylA or Cryl F (US Patent Appl. No. 61/126083 and 61/195019), or the binary toxin made up of the VIP3 protein and the Cry2Aa or Cry2Ab or Cry2Ae proteins (US Patent Appl. No.
12/214,022 and EP
08010791.5).
10) a protein of 9) above wherein some, particularly 1 to 10, amino acids have been replaced by another amino acid to obtain a higher insecticidal activity to a target insect species, and/or to expand the range of target insect species affected, and/or because of changes introduced into the encoding DNA during cloning or transformation (while still encoding an insecticidal protein) Of course, an insect-resistant transgenic plant, as used herein, also includes any plant comprising a combination of genes encoding the proteins of any one of the above classes 1 to 10. In one embodiment, an insect-resistant plant contains more than one transgene encoding a protein of any one of the above classes 1 to 10, to expand the range of target insect species affected when using different proteins directed at different target insect species, or to delay insect resistance development to the plants by using different proteins insecticidal to the same target insect species but having a different mode of action, such as binding to different receptor binding sites in the insect.
An "insect-resistant transgenic plant", as used herein, further includes any plant containing at least one transgene comprising a sequence producing upon expression a double-stranded RNA which upon ingestion by a plant insect pest inhibits the growth of this insect pest..
Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are tolerant to abiotic stresses. Such plants can be obtained by genetic transformation, or by selection of plants containing a mutation imparting such stress resistance. Particularly useful stress tolerance plants include:
1) plants which contain a transgene capable of reducing the expression and/or the activity of poly(ADP-ribose) polymerase (PARP) gene in the plant cells or plants.
- 31 -2) plants which contain a stress tolerance enhancing transgene capable of reducing the expression and/or the activity of the PARG encoding genes of the plants or plants cells.
3) plants which contain a stress tolerance enhancing transgene coding for a plant-functional enzyme of the nicotineamide adenine dinucleotide salvage synthesis pathway including nicotinamidase, nicotinate phosphoribosyltransferase, nicotinic acid mononucleotide adenyl transferase, nicotinamide adenine dinucleotide synthetase or nicotine amide phosphorybosyltransferase.
Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention show altered quantity, quality and/or storage-stability of the harvested product and/or altered properties of specific ingredients of the harvested product such as :
1) transgenic plants which synthesize a modified starch, which in its physical-chemical characteristics, in particular the amylose content or the amylose/amylopectin ratio, the degree of branching, the average chain length, the side chain distribution, the viscosity behaviour, the gelling strength, the starch grain size and/or the starch grain morphology, is changed in comparison with the synthesised starch in wild type plant cells or plants, so that this is better suited for special applications.
2) transgenic plants which synthesize non starch carbohydrate polymers or which synthesize non starch carbohydrate polymers with altered properties in comparison to wild type plants without genetic modification. Examples are plants producing polyfructose, especially of the inulin and levan-type, plants producing alpha-1,4-glucans, plants producing alpha-1,6 branched alpha-1,4-glucans, plants producing alternan, 3) transgenic plants which produce hyaluronan.
4) transgenic plants or hybrid plants, such as onions with characteristics such as 'high soluble solids content', low pungency' (LP) and/or 'long storage' (LS).
Plants or plant cultivars (that can be obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are plants, such as cotton plants, with altered fiber characteristics. Such plants can be obtained by genetic transformation, or by selection of plants contain a mutation imparting such altered fiber characteristics and include:
a) Plants, such as cotton plants, containing an altered form of cellulose synthase genes b) Plants, such as cotton plants, containing an altered form of rsw2 or rsw3 homologous nucleic acids Plants, such as cotton plants, with increased expression of sucrose phosphate synthase
- 32 -c) Plants, such as cotton plants, with increased expression of sucrose Plants, such as cotton plants, wherein the timing of the plasmodesmatal gating at the basis of the fiber cell is altered, e.g. through downregulation of fiber-selective 13-1,3-glucanase d) Plants, such as cotton plants, having fibers with altered reactivity, e.g.
through the expression of N-acetylglucosaminetransferase gene including nodC and chitin synthase genes Plants or plant cultivars (that can be obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are plants, such as oilseed rape or related Brassica plants, with altered oil profile characteristics. Such plants can be obtained by genetic transformation, or by selection of plants contain a mutation imparting such altered oil profile characteristics and include:
a) Plants, such as oilseed rape plants, producing oil having a high oleic acid content b) Plants such as oilseed rape plants, producing oil having a low linolenic acid content c) Plant such as oilseed rape plants, producing oil having a low level of saturated fatty acids Plants or plant cultivars (that can be obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are plants, such as potatoes which are virus-resistant, e.g. against potato virus Y (event SY230 and 5Y233 from Tecnoplant, Argentina), which are disease resistant, e.g. against potato late blight (e.g. RB gene), which show a reduction in cold-induced sweetening ( carrying the Nt-Inhh, IIR-INV gene) or which possess a dwarf phenotype (Gene A-20 oxidase).
Plants or plant cultivars (that can be obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are plants, such as oilseed rape or related Brassica plants, with altered seed shattering characteristics. Such plants can be obtained by genetic transformation, or by selection of plants contain a mutation imparting such altered seed shattering characteristics and include plants such as oilseed rape plants with delayed or reduced seed shattering.
Particularly useful transgenic plants which may be treated according to the invention are plants containing transformation events, or combination of transformation events, that are the subject of petitions for non-regulated status, in the United States of America, to the Animal and Plant Health Inspection Service (APHIS) of the United States Department of Agriculture (USDA) whether such petitions are granted or are still pending. At any time this information is readily available from APHIS
( 4 7 0 0 R i v e r R o a d Riverdale, MD 20737, USA), for instance on its internet site (URL
- 33 -http://www.aphis.usda.gov/brs/not_reg.html). On the filing date of this application the petitions for nonregulated status that were pending with APHIS or granted by APHIS were those listed in table B
which contains the following information:
- Petition : the identification number of the petition. Technical descriptions of the transformation events can be found in the individual petition documents which are obtainable from APHIS, for example on the APHIS website, by reference to this petition number. These descriptions are herein incorporated by reference.
- Extension of Petition : reference to a previous petition for which an extension is requested.
- Institution : the name of the entity submitting the petition.
- Regulated article : the plant species concerned.
- Transgenic phenotype : the trait conferred to the plants by the transformation event.
- Transformation event or line : the name of the event or events (sometimes also designated as lines or lines) for which nonregulated status is requested.
- APHIS documents : various documents published by APHIS in relation to the Petition and which can be requested with APHIS.
Additional particularly useful plants containing single transformation events or combinations of transformation events are listed for example in the databases from various national or regional regulatory agencies (see for example http://gmoinfo.jrc.it/gmp_browse.aspx and http://cera-gmc. org/index.php? evidco de=&hstIDXC o de=&gTyp e=&AbbrC ode=& atC ode=& stC
ode=&c oID C o de=
&action=gm_crop_database&mode=Submit) .
The compositions according to the invention comprises a) Fluopyram, b) optionally one or more active ingredients selected from insecticides, fungicides, biological control agents as disclosed above, c) optionally fertilizer or growth promoters.
The compositions according to the invention can be applied directly, that is to say without comprising further components and without having been diluted. In general, it is preferable to apply the composition to the seed in the form of a suitable formulation. Suitable formulations and methods for the treatment of seed are known to the skilled worker and are described, for example, in the following documents: US
- 34 -4,272,417 A, US 4,245,432 A, US 4,808,430 A, US 5,876,739 A, US 2003/0176428 Al, WO
2002/080675 Al, WO 2002/028186 A2.
The active compound combinations or compositions which can be used according to the invention can be converted into customary seed dressing formulations, such as solutions, emulsions, suspensions, powders, foams, slurries or other coating materials for seed, and also ULV
formulations.
These formulations are prepared in a known manner by mixing the active compounds or active compound combinations or compositiions with customary additives, such as, for example, customary extenders and also solvents or diluents, colorants, wetting agents, dispersants, emulsifiers, defoamers, preservatives, secondary thickeners, adhesives, gibberellins and optionally water as well.
Suitable colorants that may be present in the seed dressing formulations of the invention include all colorants customary for such purposes. Use may be made both of pigments, of sparing solubility in water, and of dyes, which are soluble in water. Examples that may be mentioned include the colorants known under the designations rhodamine B, C.I. Pigment Red 112, and C.I.
Solvent Red 1.
Suitable wetting agents that may be present in the seed dressing formulations of the invention include all substances which promote wetting and are customary in the formulation of active agrochemical substances.
With preference it is possible to use alkylnaphthalene-sulphonates, such as diisopropyl- or diisobutylnaphthalene-sulphonates.
Suitable dispersants and/or emulsifiers that may be present in the seed dressing formulations of the invention include all nonionic, anionic, and cationic dispersants which are customary in the formulation of active agrochemical substances. With preference, it is possible to use nonionic or anionic dispersants or mixtures of nonionic or anionic dispersants. Particularly suitable nonionic dispersants are ethylene oxide-propylene oxide block polymers, alkylphenol polyglycol ethers, and tristyrylphenol polyglycol ethers, and their phosphated or sulphated derivatives. Particularly suitable anionic dispersants are lignosulphonates, polyacrylic salts, and arylsulphonate-formaldehyde condensates.
Suitable defoamers that may be present in the seed dressing formulations of the invention include all foam-inhibiting substances which are customary in the formulation of active agrochemical substances. With preference it is possible to use silicone defoamers and magnesium stearate.
Suitable preservatives that may be present in the seed dressing formulations of the invention include all substances which can be used for such purposes in agrochemical compositions.
By way of example, mention may be made of dichlorophen and benzyl alcohol hemiformal.
Suitable secondary thickeners that may be present in the seed dressing formulations of the invention include all substances which can be used for such purposes in agrochemical compositions. Preferred suitability is
- 35 -possessed by cellulose derivatives, acrylic acid derivatives, xanthan, modified clays, and highly disperse silica.
Suitable adhesives that may be present in the seed dressing formulations of the invention include all customary binders which can be used in seed dressing. With preference, mention may be made of polyvinylpyrrolidone, polyvinyl acetate, polyvinyl alcohol and tylose.
The seed dressing formulations to be used according to the invention may be used directly or after dilution with water beforehand to treat seed of any of a very wide variety of types.
For instance, the concentrates or the preparations obtainable therefrom by dilution with water may be used to dress the seed of cereals, such as wheat, barley, rye, oats, and triticale, and also the seed of maize, rice, oilseed rape, peas, field beans, cotton, sunflowers, and beets, or else vegetable seed of any of a very wide variety of kinds. The suitable seed dressing formulations of the invention or their dilute preparations may also be used to dress seed of transgenic plants. In this context, synergistic effects may also arise in interaction with the substances formed by expression.
Suitable mixing equipment for treating seed with the seed dressing formulations to be used according to the invention or the preparations prepared from them by adding water includes all mixing equipment which can commonly be used for dressing. The specific procedure adopted when dressing comprises introducing the seed into a mixer, adding the particular desired amount of seed dressing formulation, either as it is or following dilution with water beforehand, and carrying out mixing until the formulation is uniformly distributed on the seed. Optionally, a drying operation follows.
The application rate of the seed dressing formulations to be used according to the invention may be varied within a relatively wide range. It depends on the respective content of the active compounds in the formulations and on the seed. In general, the application rates of active compound combination are between 0.001 and 200 g per kilogram of seed, preferably between 0.01 and 15 g per kilogram of seed.
The good fungicidal action of the active compounds to be used according to the invention in the treatment of seed is demonstrated by the examples below.
- 36 -Use examples Pyrenophora graminea test (winter barley) / seed treatment field trial The compound was applied as a standard "SC"-seed treatment formulation in comparison to an untreated control.
The infected seeds and the compound were put with the desired amounts in a seed treatment can and were shaken for 1-2 minutes to ensure a homogenized distribution of the compound onto the seeds. The plot size on the field was 2 m x 1 m (= 2 m2) and three replicates were used. The soil cultivation, seedbed preparation, fertilization and the application of plant protection products occurred according to the good agricultural practise. The test was evaluated at BBCH 69. 0% means an efficacy which corresponds to that of the control, while an efficacy of 100% means that no disease was observed.
Table Pyrenophora graminea test (winter barley) / seed treatment Active compound Structure Rate of application Efficacy of active compound in %
in g a.i./100kg seed Fluopyram F 10 100 F--CI F F
F

NN
H
401 2,5 99,6 98,7 In vitro microtest Pyrenophora graminea, Pyrenophora tritici-repentis, Pyrenophora teres.
The microtest was performed in liquid medium with potato-dextrose broth (PDB) using microtitre plates.
The active compound is applied as the technical active substance dissolved in methanol and 8 cioncentrations were prepared. The resulting concentration range was 0;
0.0003; 0.001; 0.003; 0.01; 0.03;
0.1 and 0.3 [tg a.i. /ml for Pyrenophora gramininea and Pyrenophora teres as well as 0; 0.03; 0.1; 0.3; 1; 3; 10 and 30 [tg a.i. /ml for Pyrenophora tritici-repentis.
- 37 -A mycelium suspension of Pyrenophora graminea or a spore suspension in the case of P. tritici-repentis or P. teres was used for inoculation. After 5 days of incubation for Pyrenophora graminea and P. teres or 7 days of incubation for Pyrenophora tritici-repentis by darkness under shaking (10 Hrz), the optical density in each cavity was determined photometrically at 620 rim. EC50 values were calculated according to the extinction values (the EC50 is a central characteristic of the isolate - it shows the concentration at which the pathogen growth coverage is reduced by 50%).
Pyrenophora graminea test /in vitro Active compound Structure (ppm) Fluopyram F
F--CI F F
F

0.08 NN
H

Pyrenophora teres test /in vitro Active compound Structure (ppm) Fluopyram F
F--CI F F
F

0.07 NN
H

Pyrenophora tritici repentis test /in vitro Active compound Structure (ppm)
- 38 -Fluopyram F
F--CI F F

I F
0.06 e"N 410 H

Claims (14)

claims
1. Use of Fluopyram of the formula (I) as well as the N-oxides of the compound thereof for treating (dressing) seed against attack by seed borne Pyrenophora species.
2 Use according to Claim 1 for treating seed against attack by Pyrenophora avenae, Pyrenophora graminea, Pyrenophora teres, Pyrenophora semeniperda, Pyrenophora tritici-repentis.
3 Use according to any of Claims 1 to 2 or treating seed against attack by seed borne Pyrenophora graminea, seed-borne P. tritici-repentis and seed-borne P. teres .
4 Use according to any of Claims 1 to 3 for treating barley seed against attack by seed borne Pyrenophora graminea and Pyrenophora teres.
Use according to any of Claims 1 to 3 for treating wheat seed against attack by seed borne Pyrenophora tritici-repentis
6 Composition for treating seed against attack by phytopathogenic fungi, which composition comprises fluopyram according to the formula (I).
7. Composition according to Claim 6 for treating seed against attack by phytopathogenic fungi, which composition comprises further at least one fungicide.
8. Composition according to Claim 6 for treating seed against attack by phytopathogenic fungi, which composition comprises further at least one insecticide
9. Composition according to any of Claims 6 to 8 for treating seed against attack by seed borne Pyrenophora graminea, seed-borne P. tritici-repentis and seed-borne P. teres .
10. Composition according to any of Claims 6 to 8 for treating barley seed against attack by Pyrenophora graminea and Pyrenophora teres.
11. Composition according to any of Claims 6 to 9 for treating wheat seed against attack by seed borne Pyrenophora tritici-repentis
12. Method for controlling phytopathogenic fungi, characterized in that seed is treated with Fluopyram according to Claim 1.
13. Method according to Claim 12 for controlling seed borne Pyrenophora graminea, seed-borne P.
tritici-repentis and seed-borne P. teres .
14. Seed which has been treated with Fluopyram according to Claim 1 for protection against attack by phytopathogenic fungi.
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CN104630071B (en) * 2014-12-22 2017-12-01 吉林农业大学 Spore trichoderma and its application more than one plant
WO2019171390A1 (en) * 2018-03-04 2019-09-12 Surjyoti Sujalchandra Bagchi A composition useful as a pest-controlling agent for agricultural and horticultural crops
CN108684418A (en) * 2018-05-17 2018-10-23 金华市胤宏农业科技有限公司 The method for culturing seedlings of cherry
CN109679931A (en) * 2019-01-30 2019-04-26 天津大学 A kind of Celastrus angulatus acyltransferase 35019 and its gene order
CN111602663A (en) * 2019-02-25 2020-09-01 中国农业大学 Suspension type thread-killing seed coating agent
RU2722755C1 (en) * 2019-07-11 2020-06-03 Акционерное общество Фирма "Август" Insectofungicidal composition, use thereof and method of protecting agricultural crops

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4272417A (en) 1979-05-22 1981-06-09 Cargill, Incorporated Stable protective seed coating
US4245432A (en) 1979-07-25 1981-01-20 Eastman Kodak Company Seed coatings
US4808430A (en) 1987-02-27 1989-02-28 Yazaki Corporation Method of applying gel coating to plant seeds
GB8810120D0 (en) 1988-04-28 1988-06-02 Plant Genetic Systems Nv Transgenic nuclear male sterile plants
US5084082A (en) 1988-09-22 1992-01-28 E. I. Du Pont De Nemours And Company Soybean plants with dominant selectable trait for herbicide resistance
US5198599A (en) 1990-06-05 1993-03-30 Idaho Resarch Foundation, Inc. Sulfonylurea herbicide resistance in plants
WO1992000964A1 (en) 1990-07-05 1992-01-23 Nippon Soda Co., Ltd. Amine derivative
RO117111B1 (en) 1993-03-25 2001-10-30 Ciba Geigy Ag Pesticidal proteine and nucleotide sequence encoding the same
US6406690B1 (en) 1995-04-17 2002-06-18 Minrav Industries Ltd. Bacillus firmus CNCM I-1582 or Bacillus cereus CNCM I-1562 for controlling nematodes
FR2734842B1 (en) 1995-06-02 1998-02-27 Rhone Poulenc Agrochimie DNA SEQUENCE OF A HYDROXY-PHENYL PYRUVATE DIOXYGENASE GENE AND OBTAINING PLANTS CONTAINING A HYDROXY-PHENYL PYRUVATE DIOXYGENASE GENE, TOLERANT TO CERTAIN HERBICIDES
US5773704A (en) 1996-04-29 1998-06-30 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Herbicide resistant rice
US5876739A (en) 1996-06-13 1999-03-02 Novartis Ag Insecticidal seed coating
US5773702A (en) 1996-07-17 1998-06-30 Board Of Trustees Operating Michigan State University Imidazolinone herbicide resistant sugar beet plants
FR2770854B1 (en) 1997-11-07 2001-11-30 Rhone Poulenc Agrochimie DNA SEQUENCE OF A GENE OF HYDROXY-PHENYL PYRUVATE DIOXYGENASE AND PRODUCTION OF PLANTS CONTAINING SUCH A GENE, HERBICIDE TOLERANT
FR2772789B1 (en) 1997-12-24 2000-11-24 Rhone Poulenc Agrochimie PROCESS FOR THE ENZYMATIC PREPARATION OF HOMOGENTISATE
DE19821614A1 (en) 1998-05-14 1999-11-18 Hoechst Schering Agrevo Gmbh Sugar beet mutants which are tolerant to sulfonylurea herbicides
US6503904B2 (en) 1998-11-16 2003-01-07 Syngenta Crop Protection, Inc. Pesticidal composition for seed treatment
AU2001242005B2 (en) 2000-03-09 2006-04-27 Monsanto Technology Llc Methods for making plants tolerant to glyphosate and compositions thereof
AU2001238631A1 (en) 2000-03-09 2001-09-17 E.I. Du Pont De Nemours And Company Sulfonylurea-tolerant sunflower plants
US6768044B1 (en) 2000-05-10 2004-07-27 Bayer Cropscience Sa Chimeric hydroxyl-phenyl pyruvate dioxygenase, DNA sequence and method for obtaining plants containing such a gene, with herbicide tolerance
US6303818B1 (en) 2000-08-08 2001-10-16 Dow Agrosciences Llc Unsaturated oxime ethers and their use as fungicides
US6660690B2 (en) 2000-10-06 2003-12-09 Monsanto Technology, L.L.C. Seed treatment with combinations of insecticides
FR2815969B1 (en) 2000-10-30 2004-12-10 Aventis Cropscience Sa TOLERANT PLANTS WITH HERBICIDES BY METABOLIC BYPASS
CA2427787C (en) 2000-12-07 2012-07-17 Syngenta Limited Herbicide resistant plants
US20020134012A1 (en) 2001-03-21 2002-09-26 Monsanto Technology, L.L.C. Method of controlling the release of agricultural active ingredients from treated plant seeds
BRPI0209726B1 (en) 2001-05-31 2015-06-30 Nihon Nohyaku Co Ltd Substituted anilide derivative, agricultural and horticultural chemical, and method for applying the same
AR037328A1 (en) 2001-10-23 2004-11-03 Dow Agrosciences Llc COMPOSITE OF [7-BENCIL-2,6-DIOXO-1,5-DIOXONAN-3-IL] -4-METOXIPIRIDIN-2-CARBOXAMIDE, COMPOSITION THAT UNDERSTANDS AND METHOD THAT USES IT
GB0213715D0 (en) 2002-06-14 2002-07-24 Syngenta Ltd Chemical compounds
EP1389614A1 (en) * 2002-08-12 2004-02-18 Bayer CropScience S.A. Novel N-[2-(2-Pyridyl)ethyl]benzamide derivatives as fungicides
MXPA05001580A (en) 2002-08-12 2005-04-25 Bayer Cropscience Sa Novel 2-pyridylethylbenzamide derivative.
FR2844142B1 (en) 2002-09-11 2007-08-17 Bayer Cropscience Sa TRANSFORMED PLANTS WITH ENHANCED PRENYLQUINON BIOSYNTHESIS
WO2004039155A1 (en) 2002-10-31 2004-05-13 Ishihara Sangyo Kaisha, Ltd. 3-benzoyl-2,4,5-substituted pyridine derivatives or salts thereof and bactericides containing the same
GB0230155D0 (en) 2002-12-24 2003-02-05 Syngenta Participations Ag Chemical compounds
TWI312272B (en) 2003-05-12 2009-07-21 Sumitomo Chemical Co Pyrimidine compound and pests controlling composition containing the same
UA79404C2 (en) 2003-10-02 2007-06-11 Basf Ag 2-cyanobenzenesulfonamide for controlling pests
CN100450997C (en) 2003-10-31 2009-01-14 三井化学株式会社 Diamine derivative, process for producing the same, and plant disease control agent containing the same as active ingredient
GB0329744D0 (en) 2003-12-23 2004-01-28 Koninkl Philips Electronics Nv A beverage maker incorporating multiple beverage collection chambers
AU2005206437B2 (en) 2004-01-23 2010-08-12 Mitsui Chemicals Agro, Inc. 3-(dihydro(tetrahydro)isoquinolin-1-yl)quinolines
ES2560879T3 (en) 2004-02-18 2016-02-23 Ishihara Sangyo Kaisha, Ltd. Anthranilamides, process for their production and pest controllers containing the same
ES2526614T3 (en) 2004-03-05 2015-01-13 Nissan Chemical Industries, Ltd. Isoxazoline-substituted benzamide compound and harmful organisms control agent
RU2394819C2 (en) 2004-10-20 2010-07-20 Кумиай Кемикал Индастри Ко., Лтд. Insecticide, acaricide and namatocide, containing 3-triazolylphenyl sulphide derivative as active component
EA200700972A1 (en) 2004-11-26 2007-12-28 Басф Акциенгезельшафт NEW 2-CYANO-3- (GALO) ALCOXYBENZENESULPHONAMIDE CONNECTIONS TO COMBAT ANIMALS-PESTS
DE102005008021A1 (en) 2005-02-22 2006-08-24 Bayer Cropscience Ag New spiroketal-substituted cyclic ketoenol compounds used for combating animal parasites, undesired plant growth and/or undesired microorganisms
CA2601072A1 (en) 2005-03-24 2006-09-28 Basf Aktiengesellschaft 2-cyanobenzenesulfonamide compounds for seed treatment
TW200738701A (en) 2005-07-26 2007-10-16 Du Pont Fungicidal carboxamides
ES2400809T3 (en) 2005-08-31 2013-04-12 Monsanto Technology Llc Nucleotide sequences encoding insecticidal proteins
EA014057B1 (en) 2005-10-06 2010-08-30 Ниппон Сода Ко., Лтд. Bridged cyclic amine compound and pest control agent
PE20070847A1 (en) 2005-11-21 2007-09-21 Basf Ag COMPOUNDS DERIVED FROM 3-AMINO-1,2-BENCISOTIAZOLE AS INSECTICIDES
TW200803740A (en) 2005-12-16 2008-01-16 Du Pont 5-aryl isoxazolines for controlling invertebrate pests
US20070214515A1 (en) 2006-03-09 2007-09-13 E.I.Du Pont De Nemours And Company Polynucleotide encoding a maize herbicide resistance gene and methods for use
WO2007101369A1 (en) 2006-03-09 2007-09-13 East China University Of Science And Technology Preparation method and use of compounds having high biocidal activities
US20100235951A1 (en) 2006-03-21 2010-09-16 Bayer Bioscience N.V. Novel genes encoding insecticidal proteins
DE102006015470A1 (en) 2006-03-31 2007-10-04 Bayer Cropscience Ag New cyclic enamine ketone derivatives useful for controlling pests, especially insects
DE102006015468A1 (en) 2006-03-31 2007-10-04 Bayer Cropscience Ag New cyclic enamine ketone derivatives useful for controlling pests, especially insects
DE102006015467A1 (en) 2006-03-31 2007-10-04 Bayer Cropscience Ag New cyclic enamine ketone derivatives useful for controlling pests, especially insects
TWI381811B (en) 2006-06-23 2013-01-11 Dow Agrosciences Llc A method to control insects resistant to common insecticides
DE102006033572A1 (en) 2006-07-20 2008-01-24 Bayer Cropscience Ag N'-cyano-N-haloalkyl-imideamide derivatives
WO2008013622A2 (en) 2006-07-27 2008-01-31 E. I. Du Pont De Nemours And Company Fungicidal azocyclic amides
JP5047588B2 (en) 2006-10-31 2012-10-10 Meiji Seikaファルマ株式会社 Quinoline derivatives and agricultural and horticultural insecticides comprising the same
WO2008066153A1 (en) 2006-11-30 2008-06-05 Meiji Seika Kaisha, Ltd. Pest control agent
DE102006057036A1 (en) 2006-12-04 2008-06-05 Bayer Cropscience Ag New biphenyl substituted spirocyclic ketoenol derivatives useful for the manufacture of herbicides and for combating parasites
JP5511393B2 (en) 2007-03-01 2014-06-04 ビーエーエスエフ ソシエタス・ヨーロピア Pesticide active mixtures containing aminothiazoline compounds
AR066787A1 (en) 2007-05-30 2009-09-09 Syngenta Participations Ag GENES OF THE CYCROCHROME P450 THAT CONFERENCE RESISTANCE TO HERBICIDES
CL2008001647A1 (en) 2007-06-08 2008-10-10 Syngenta Participations Ag COMPOUNDS DERIVED FROM FENILETIL-AMIDA ACIDO-1H-PIRAZOL-4-CARBOXILICO; COMPOUNDS DERIVED FROM (FENILETIL) AMINA; METHOD TO CONTROL OR PREVENT INFRASTATION OF PLANTS BY PHYTOOPATHOGEN MICROORGANISMS; AND COMPOSITION FOR CONTROL
GB0720126D0 (en) 2007-10-15 2007-11-28 Syngenta Participations Ag Chemical compounds
EP2562162B1 (en) 2008-01-22 2015-08-19 Dow AgroSciences LLC N-cyano-4-amino-5-fluoro-pyrimidine derivatives as fungicides
CN105368799A (en) 2008-04-14 2016-03-02 拜耳作物科学公司 Mutated hydroxyphenylpyruvate dioxygenase, dna sequence and isolation of plants which are tolerant to hppd inhibitor herbicides
WO2010005692A2 (en) 2008-06-16 2010-01-14 E. I. Du Pont De Nemours And Company Insecticidal cyclic carbonyl amidines
JP5268461B2 (en) 2008-07-14 2013-08-21 Meiji Seikaファルマ株式会社 PF1364 substance, its production method, production strain, and agricultural and horticultural insecticide containing the same as an active ingredient
EP2586311B1 (en) 2008-07-17 2016-12-14 Bayer CropScience AG Heterocyclic compounds as pest controllers
US8268843B2 (en) 2008-08-29 2012-09-18 Dow Agrosciences, Llc. 5,8-difluoro-4-(2-(4-(heteroaryloxy)-phenyl)ethylamino)quinazolines and their use as agrochemicals
ES2544490T3 (en) 2008-12-18 2015-08-31 Bayer Intellectual Property Gmbh Tetrazol-substituted anthranilic acid amides as pesticides
PL2369935T3 (en) 2008-12-26 2017-04-28 Dow Agrosciences, Llc Stable insecticide compositions and methods for producing same
KR101702337B1 (en) 2008-12-26 2017-02-03 다우 아그로사이언시즈 엘엘씨 Stable sulfoximine-insecticide compositions
CN102348380B (en) * 2009-03-16 2013-10-23 巴斯夫欧洲公司 Fungicidal compositions comprising fluopyram and metrafenone
BRPI1011983A2 (en) * 2009-06-02 2015-09-22 Bayer Cropscience Ag use of succinate dehydrogenase inhibitors for sclerotinia ssp control.
KR20120098645A (en) 2009-10-23 2012-09-05 스미또모 가가꾸 가부시끼가이샤 Pest control composition
WO2011076727A2 (en) * 2009-12-23 2011-06-30 Bayer Cropscience Ag Pesticidal compound mixtures
CN102057925B (en) 2011-01-21 2013-04-10 陕西上格之路生物科学有限公司 Insecticidal composition containing thiacloprid amide and biogenic insecticide

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