CA2308375C - Multispectral/hyperspectral medical instrument - Google Patents
Multispectral/hyperspectral medical instrument Download PDFInfo
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- CA2308375C CA2308375C CA2308375A CA2308375A CA2308375C CA 2308375 C CA2308375 C CA 2308375C CA 2308375 A CA2308375 A CA 2308375A CA 2308375 A CA2308375 A CA 2308375A CA 2308375 C CA2308375 C CA 2308375C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/05—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances characterised by the image sensor, e.g. camera, being in the distal end portion
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00002—Operational features of endoscopes
- A61B1/00039—Operational features of endoscopes provided with input arrangements for the user
- A61B1/00042—Operational features of endoscopes provided with input arrangements for the user for mechanical operation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0088—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for oral or dental tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/36—Image-producing devices or illumination devices not otherwise provided for
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- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
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- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Optics & Photonics (AREA)
- Radiology & Medical Imaging (AREA)
- Mechanical Engineering (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Endoscopes (AREA)
- Instruments For Viewing The Inside Of Hollow Bodies (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
A medical instrument that comprises: a first-stage optic (40) responsive to a tissue surface of a patient; a spectral separator (42) optically responsive to the first stage optic and having a control input; an imaging sensor (46) optically responsive to the spectral separator and having an image data output; and a diagnostic processor (38) having an image acquisition interface (50) with an input responsive to the imaging sensor and a filter control interface (52) having a control output provided to the control input of the spectral separator (42).
Description
wo ~n2t~ao Pcrnrs98nzm Mtli TISPECTRAL/FiYPERSPECTR.AL MEDICAL INSTRUMENT
Field of the Invention The invention relates to a surgical and diagnostic instrument for performing real-time general-purpose imaging during surgery, clinical procedures, or other medical evaluations.
Back~eround of the Invention Spectroscopic imaging devices which employ Acousto-Optic Tunable Filters (AOTF), Liquid Crystal Tunable Filters (LCTF), or dispersive gratings are Irnown. Such devices have been used for microscopy and remote sensing.
Summary of the Invention Generally, the invention features a medical instrument that includes an optic responsive to a surface of tissue of a patient, a spectral separator optically responsive to the optic, and an imaging sensor optically responsive to the spectral separator. The instrument also includes a diagnostic processor having an image acquisition interface responsive to the imaging sensor and a filter control interface to which the spectral separator is responsive.
The spxtral separator can be a tunable filter, such as a liquid crystal tunable filter, and the imaging sensor can be a two-dimensional imaging array, such as a charge coupled device.
The optic can include a macro lens, an adjustable lens; or a probe that includes an imaging fiber optic cable, and a stand can be connected relative to the optic to position the optic relative to the patient. The control interface can be operable to adjust the filter at least twenty times to acquire hyperspectral data for redisplay in real time. The medical instrument can perform diagnostic processing for images acquired exclusively under visible light.
The diagnostic processor can also include a general-purpose processing module and diagnostic protocol modules, which can each include filter transfer functions and an image processing protocol. The general-purpose processing module can be operative to instruct the filter to successively apply the filter transfer functions to light collected from the patient, to acquire from the imaging sensor a number of images of the collected light each obtained after one of the filter transfer fimctions is applied, and to process the acquired images according to the image processing protocol to obtain a processed display image. The general-purpose processor can be a real-time processor operative to generate a processed display image within a time period on the order of the persistence of human vision. It may also be operative to acquire some images more slowly depending on the number of wavelengths and complexity of diagnostic processing protocol. The sensor and filter can be operative in the visible, infra-red, and LTV regions.
Instruments according to the invention are advantageous in that they can permit a surgeon or a physician to diagnose a medical condition or develop a surgical strategy based on real-time images obtained during surgery or in the course of performing clinical procedures or other medical evaluations. The physician may therefore be able to obtain significantly more information about a patient's condition than he might otherwise have been able to assemble by presenting an interactive interface. This additional information may permit a given surgical procedure to be carried out more precisely and may lead to more successful surgical results. It may also enhance the precision and results of other types of medical evaluations and procedures.
The general-purpose nature of the instrument can also help the surgeon develop significant amounts of medical information in time-critical surgical situations. For example, a patient may undergo relatively straight-forward surgery during which the surgeon may discover a tumor or another internal condition. With an instrument according to the invention, the physician can spend a small amount of additional time with the patient under anesthesia and determine the nature and extent of the tumor. This can be particularly beneficial during major surgery, where extending surgery duration poses a potential morbidity and mortality risk.
Because the procedure is rapid and noninvasive, the patient is exposed to little additional risk.
The benefit of immediate diagnosis and evaluation is significant.
An instrument according to the invention tray also be able to provide a wide variety of diagnostic capabilities, allowing a physician to enhance the capabilities of his or her practice substantially in a variety of different realms, without investing in a number of instruments. The wo ~nzs~o rcrius9snzm physician can then enhance or update the instrument by the adding software modules that are specifically targeted towards certain conditions of particular tissues, subsystems, or disease states. This can allow a single base instrument to be configured for a variety of different types of practices, and priced according to the type of practice to be served by the instrument. For example, a general-purpose instrument to be used by a general surgeon could include a package of diagnostic protocols that would permit the diagnosis of a variety of conditions that a general surgeon might encounter, while a neurosurgeon's module might be added to allow a specialist to detect particular conditions within the brain. Electronic and optical upgrades may also be provided to update, specialize, or improve the performance of the instrument.
Such upgrades can include processing modules, memory boards, lenses, and the like.
Descriytion of the Drawings Fig. 1 is a perspective diagram of a macroscopic instrument according to the invention;
Fig. 2 is a perspective diagram of a rigid or flexible probe-based instrument according to the invention;
Fig. 3 is a block diagram of the instrument of Fig. 1; and Fig. 4 is a flowchart illustrating the operation of the system of Fig. 1.
Detailed Description of an Illustrative Embodiment Referring to Fig. 1, an instrument according to the invention 10 includes an imaging module 12 mounted on a surgical stand 14. In this embodiment, the surgeon can direct the imaging portion 12 towards a patient 20 by manipulating a control 16 that adjusts the attitude of the imaging portion through a positioning mechanism 18.
Referring to Fig. 2, an alternative embodiment of the invention 22 may include a probe such as a rigid or flexible endoscopic, thoraeoscopic, laproscopic, or angioscopic probe 24 connected to an imaging station 30 via a fiber-optic cable 26. The surgeon can manipulate the probe within the patient in a minimally-invasive surgical procedure and derive images from a portion of the patient and display these images on a display 28. A medical implement 32, such as a laser, can also be provided through the probe. For example, after diagnosing a particular condition, a physician can begin laser ablation therapy to remedy it.
Referring to Fig. 3, a medical instrument according to the invention 34 may include an optical acquisition system 36 and a diagnostic processor 38. The acquisition system 36 includes a first-stage imaging optic 40, a Liquid Crystal Tunable Filter (LCTF) 42, a second-stage optic 44, and an imaging element 46. The first-stage optic receives light collected from the patient and focuses it onto the surface of the LCTF. The first-stage optic can be a simple or compound macro lens in the case of a macroscopic instrument (Fig. 1 ). In a probe-based instrument (Fig.
2), the first stage optic can include imaging optics within a probe such as a endoscopic, laproscopic, thoracoscopic, or angioscopic probe. The first stage lens can also be adjustable, allowing a physician to scan larger areas of tissue and then zoom into particular regions.
The LCTF 42 is a programmable filter that filters out all but a wavelength region of interest from the light collected from the patient. The second-stage optic 44 receives the remaining light from the LCTF and focuses it onto the image sensor 46. The image sensor is preferably, although not necessarily, a two-dimensional array sensor, such as a charge-coupled device array (CCD), which delivers an image signal to the diagnostic processor 38.
The diagnostic processor 38 includes an image acquisition interface 50, that has an input responsive to an output of the image sensor 46 and an output provided to a general-purpose operating module 54. The general-purpose operating module includes routines that perform image processing, and that operate and control the various parts of the system. It has a control output provided to a filter control interface 52, which in taro has an output provided to the LCTF
42. The general-purpose operating module also interacts with a number of diagnostic protocol modules 56A, 56B, ... 54N, and has an output provided to the video display 1.2. The diagnostic processor can include spxial purpose hardware, general-purpose hardware with special-purpose software, or a combination of the two. The diagnostic processor also includes an input device 58, which is operatively connected to the general-purpose operating module. A
storage device 60, and a printer are also operatively connected to the general-purpose operating module.
Field of the Invention The invention relates to a surgical and diagnostic instrument for performing real-time general-purpose imaging during surgery, clinical procedures, or other medical evaluations.
Back~eround of the Invention Spectroscopic imaging devices which employ Acousto-Optic Tunable Filters (AOTF), Liquid Crystal Tunable Filters (LCTF), or dispersive gratings are Irnown. Such devices have been used for microscopy and remote sensing.
Summary of the Invention Generally, the invention features a medical instrument that includes an optic responsive to a surface of tissue of a patient, a spectral separator optically responsive to the optic, and an imaging sensor optically responsive to the spectral separator. The instrument also includes a diagnostic processor having an image acquisition interface responsive to the imaging sensor and a filter control interface to which the spectral separator is responsive.
The spxtral separator can be a tunable filter, such as a liquid crystal tunable filter, and the imaging sensor can be a two-dimensional imaging array, such as a charge coupled device.
The optic can include a macro lens, an adjustable lens; or a probe that includes an imaging fiber optic cable, and a stand can be connected relative to the optic to position the optic relative to the patient. The control interface can be operable to adjust the filter at least twenty times to acquire hyperspectral data for redisplay in real time. The medical instrument can perform diagnostic processing for images acquired exclusively under visible light.
The diagnostic processor can also include a general-purpose processing module and diagnostic protocol modules, which can each include filter transfer functions and an image processing protocol. The general-purpose processing module can be operative to instruct the filter to successively apply the filter transfer functions to light collected from the patient, to acquire from the imaging sensor a number of images of the collected light each obtained after one of the filter transfer fimctions is applied, and to process the acquired images according to the image processing protocol to obtain a processed display image. The general-purpose processor can be a real-time processor operative to generate a processed display image within a time period on the order of the persistence of human vision. It may also be operative to acquire some images more slowly depending on the number of wavelengths and complexity of diagnostic processing protocol. The sensor and filter can be operative in the visible, infra-red, and LTV regions.
Instruments according to the invention are advantageous in that they can permit a surgeon or a physician to diagnose a medical condition or develop a surgical strategy based on real-time images obtained during surgery or in the course of performing clinical procedures or other medical evaluations. The physician may therefore be able to obtain significantly more information about a patient's condition than he might otherwise have been able to assemble by presenting an interactive interface. This additional information may permit a given surgical procedure to be carried out more precisely and may lead to more successful surgical results. It may also enhance the precision and results of other types of medical evaluations and procedures.
The general-purpose nature of the instrument can also help the surgeon develop significant amounts of medical information in time-critical surgical situations. For example, a patient may undergo relatively straight-forward surgery during which the surgeon may discover a tumor or another internal condition. With an instrument according to the invention, the physician can spend a small amount of additional time with the patient under anesthesia and determine the nature and extent of the tumor. This can be particularly beneficial during major surgery, where extending surgery duration poses a potential morbidity and mortality risk.
Because the procedure is rapid and noninvasive, the patient is exposed to little additional risk.
The benefit of immediate diagnosis and evaluation is significant.
An instrument according to the invention tray also be able to provide a wide variety of diagnostic capabilities, allowing a physician to enhance the capabilities of his or her practice substantially in a variety of different realms, without investing in a number of instruments. The wo ~nzs~o rcrius9snzm physician can then enhance or update the instrument by the adding software modules that are specifically targeted towards certain conditions of particular tissues, subsystems, or disease states. This can allow a single base instrument to be configured for a variety of different types of practices, and priced according to the type of practice to be served by the instrument. For example, a general-purpose instrument to be used by a general surgeon could include a package of diagnostic protocols that would permit the diagnosis of a variety of conditions that a general surgeon might encounter, while a neurosurgeon's module might be added to allow a specialist to detect particular conditions within the brain. Electronic and optical upgrades may also be provided to update, specialize, or improve the performance of the instrument.
Such upgrades can include processing modules, memory boards, lenses, and the like.
Descriytion of the Drawings Fig. 1 is a perspective diagram of a macroscopic instrument according to the invention;
Fig. 2 is a perspective diagram of a rigid or flexible probe-based instrument according to the invention;
Fig. 3 is a block diagram of the instrument of Fig. 1; and Fig. 4 is a flowchart illustrating the operation of the system of Fig. 1.
Detailed Description of an Illustrative Embodiment Referring to Fig. 1, an instrument according to the invention 10 includes an imaging module 12 mounted on a surgical stand 14. In this embodiment, the surgeon can direct the imaging portion 12 towards a patient 20 by manipulating a control 16 that adjusts the attitude of the imaging portion through a positioning mechanism 18.
Referring to Fig. 2, an alternative embodiment of the invention 22 may include a probe such as a rigid or flexible endoscopic, thoraeoscopic, laproscopic, or angioscopic probe 24 connected to an imaging station 30 via a fiber-optic cable 26. The surgeon can manipulate the probe within the patient in a minimally-invasive surgical procedure and derive images from a portion of the patient and display these images on a display 28. A medical implement 32, such as a laser, can also be provided through the probe. For example, after diagnosing a particular condition, a physician can begin laser ablation therapy to remedy it.
Referring to Fig. 3, a medical instrument according to the invention 34 may include an optical acquisition system 36 and a diagnostic processor 38. The acquisition system 36 includes a first-stage imaging optic 40, a Liquid Crystal Tunable Filter (LCTF) 42, a second-stage optic 44, and an imaging element 46. The first-stage optic receives light collected from the patient and focuses it onto the surface of the LCTF. The first-stage optic can be a simple or compound macro lens in the case of a macroscopic instrument (Fig. 1 ). In a probe-based instrument (Fig.
2), the first stage optic can include imaging optics within a probe such as a endoscopic, laproscopic, thoracoscopic, or angioscopic probe. The first stage lens can also be adjustable, allowing a physician to scan larger areas of tissue and then zoom into particular regions.
The LCTF 42 is a programmable filter that filters out all but a wavelength region of interest from the light collected from the patient. The second-stage optic 44 receives the remaining light from the LCTF and focuses it onto the image sensor 46. The image sensor is preferably, although not necessarily, a two-dimensional array sensor, such as a charge-coupled device array (CCD), which delivers an image signal to the diagnostic processor 38.
The diagnostic processor 38 includes an image acquisition interface 50, that has an input responsive to an output of the image sensor 46 and an output provided to a general-purpose operating module 54. The general-purpose operating module includes routines that perform image processing, and that operate and control the various parts of the system. It has a control output provided to a filter control interface 52, which in taro has an output provided to the LCTF
42. The general-purpose operating module also interacts with a number of diagnostic protocol modules 56A, 56B, ... 54N, and has an output provided to the video display 1.2. The diagnostic processor can include spxial purpose hardware, general-purpose hardware with special-purpose software, or a combination of the two. The diagnostic processor also includes an input device 58, which is operatively connected to the general-purpose operating module. A
storage device 60, and a printer are also operatively connected to the general-purpose operating module.
In operation, referring to Figs. 3 and 4, a surgeon employing the instrument begins by selecting a diagnostic protocol module using the instrument's input device (step 100). Each diagnostic protocol module is adapted to detect particular characteristics of the surface of one or more types of tissue. For example, the surgeon might select a module which enhances the visibility of cancerous tissue. The surgeon would then direct the camera at the areaof interest and begin inspecting it either under ambient light or with the aid of a supplemental light source, which can be filtered to emphasize particular special characteristics of the light it emits.
The diagnostic processor 38 responds to the surgeon's input by obtaining a series of filter transfer functions and an image processing protocol from the selected diagnostic protocol module 56. The diagnostic processor provides the filtering transfer functions to the LCTF 42 via its filter control interface 52 (step 102) and then instructs the image acquisition interface 50 to acquire and store the resulting filtered image from the image sensor 46 (step 104).
The general-purpose operating module 54 repeats these filtering and acquiring steps one or more times, depending on the number of filter transfer fimctions stored in the selected diagnostic protocol module (see step 106). The filtering transfer functions can represent bandpass, multiple bandpass, or other filter characteristics.
Once the image acquisition interface 50 has stored images for all of the image planes specified by the diagnostic protocol chosen by the surgeon, it begins processing these image planes based on the image processing protocol from the selected diagnostic protocol module 56N
(step 108). Processing operations can include general image processing of combined images, such as comparing the relative amplitude of the collected light at different wavelengths, adding amplitudes of the collected light at different wavelengths, or computing other combinations of signals corresponding to the acquired planes. The processing operations can also include more complex multivariate statistical techniques to compute the image (e.g., chemometrics). The computed image is displayed on the display 12. It can also be stored in the storage device 60 or printed out on the printer 62.
The processing operations can also be based on a diagnostic knowledge base.
This database can include data resulting from the comparison between optical and actual diagnoses.
Each instrument can also continuously update its database as it is used to perform diagnoses, thereby steadily expanding its diagnostic capabilities.
In order to provide a real-time or near-real-time image to the surgeon, the instrument repeatedly acquires planes and processes them to develop an image to be displayed to the surgeon. This allows the surgeon to move the instrument, or to view moving organs, such as a beating heart. This constant acquisition and processing continues until the surgeon either turns the instrument off (step 110) or selects a different imaging mode (step 112).
The diagnostic processor 38 preferably has sufficient processing power to update the screen in this way at video rates (i.e., about 30 frames per second), although rates as low as a few frames per second may work quite well, and rates as low as one frame per minute may be adequate for many purposes.
On slower instruments, general lock-in schemes or other tracking modalities, such as cardiac gating, can be used to remove motion artifacts due to breathing or heart beat.
Frame rate may also be variable, depending on the number of wavelengths and the complexity of the diagnostic procedure.
Preferably, the instrument can operate in multispectral, and hyperspectral, or even ultraspectral imaging modes. Multispectral modes involve image processing derived from a relatively small number of spectral image planes (two wavelengths to about twenty wavelengths). Hyperspectral and ultra spectral imaging modes involve at least twenty image planes and can produce significantly more accurate and informative results.
Ultraspectral modes involve hundreds of wavelengths, and may be able to produce even further information about the patient. Hyptrspectral and ultraspectral imaging may include selecting specific wavelength bands for discrunination of a particular diseased states, or it may also allow the instrument to scan for multiple conditions at the same time.
It is also contemplated that both types of instrument can operate in connection with an excitation source, such as an ultraviolet lamp and IR source, or other means of spectral illumination or a laser to enhance the received images. Although such excitation may not be necessary, it may allow for the examination of different optical phenomenon and provide additional diagnostic information. And both emission and reflectance modes can be combined in a diagnostic procedure either simultaneously or sequentially. Relative utilization of different emission or reflection measurements involved in the same diagnostic procedure can be obtained by modulating the different sources. The instrument can also develop light from bioluminescent sources introduced.into the patient.
Instruments according to the invention can also operate to process images from image planes acquired at wavelengths outside of the visible region. In one particular embodiment, the instrument is sensitive to the visible and near infra-red regions. It is also contemplated that far infra-red be included to allow the instrument to sense molecular-specific rotational modes.
An example of operation would include the use of a diagnostic protocol module that examined a first wavelength of about S50 and a second wavelength of about 575 associated with oxy- and deoxy-hemoglobin to determine blood oxygenation. The relationship between these wavelengths is described in "Hemoglobin: Molecular Genetics and Clinical Aspects," by H.
Franklin Bunn and Bernard Forget, W. B. Sanders, 1986. Another example would include the use of a diagnostic protocol module for examining the Fourier transform infra-red spectra of the colon and rectum as described in "Human Colorectal Cancers Display Abnormal Fourier Transform Spectra, " by Basil Rigas et al., Proceedings of the National Academy of Science, pp.
8140-8144, 1987.
Surgical and medical applications of instruments according to the invention can include, but are not limited to, determining tissue viability (i.e. whether tissue is dead or living tissue and whether it is predicted to remain living), detecting tissue ischemia (e.g., in heart, or in leg after a gunshot wound, differentiating between normal and malignant cells and tissues (e.g., delineating tumors, dysplasias and precaucerous tissue, detecting metastasis), differentiating between of infected and normal (but inflamed) tissue (e.g., extent of aortic root infection), quantification and identification of pathogens, (e.g., bacterial count of burn wounds and differentiating and delineating other pathologic states. Application can also include tissue, blood chemistry, and blood flow (including oxy- and deoxyhemoglobin, myoglobin deoxymyoglobin, cytochrome, pH, glucose, calcium and other elements or biological compounds alone or in combination). The instrument can also be applied by veterinarians to animals and by dentists to dental applications, such as peridental disease.
The present invention has now been described in connection with a number of specific embodiments thereof. However, numerous modifications which are contemplated as falling within the scope of the present invention should now be apparent to those skilled in the art.
Therefore, it is intended that the scope of the present invention be limited only by the scope of the claims appended hereto. In addition, the order of presentation of the claims should not be construed to limit the scope of any particular term in the claims.
What is claimed is:
The diagnostic processor 38 responds to the surgeon's input by obtaining a series of filter transfer functions and an image processing protocol from the selected diagnostic protocol module 56. The diagnostic processor provides the filtering transfer functions to the LCTF 42 via its filter control interface 52 (step 102) and then instructs the image acquisition interface 50 to acquire and store the resulting filtered image from the image sensor 46 (step 104).
The general-purpose operating module 54 repeats these filtering and acquiring steps one or more times, depending on the number of filter transfer fimctions stored in the selected diagnostic protocol module (see step 106). The filtering transfer functions can represent bandpass, multiple bandpass, or other filter characteristics.
Once the image acquisition interface 50 has stored images for all of the image planes specified by the diagnostic protocol chosen by the surgeon, it begins processing these image planes based on the image processing protocol from the selected diagnostic protocol module 56N
(step 108). Processing operations can include general image processing of combined images, such as comparing the relative amplitude of the collected light at different wavelengths, adding amplitudes of the collected light at different wavelengths, or computing other combinations of signals corresponding to the acquired planes. The processing operations can also include more complex multivariate statistical techniques to compute the image (e.g., chemometrics). The computed image is displayed on the display 12. It can also be stored in the storage device 60 or printed out on the printer 62.
The processing operations can also be based on a diagnostic knowledge base.
This database can include data resulting from the comparison between optical and actual diagnoses.
Each instrument can also continuously update its database as it is used to perform diagnoses, thereby steadily expanding its diagnostic capabilities.
In order to provide a real-time or near-real-time image to the surgeon, the instrument repeatedly acquires planes and processes them to develop an image to be displayed to the surgeon. This allows the surgeon to move the instrument, or to view moving organs, such as a beating heart. This constant acquisition and processing continues until the surgeon either turns the instrument off (step 110) or selects a different imaging mode (step 112).
The diagnostic processor 38 preferably has sufficient processing power to update the screen in this way at video rates (i.e., about 30 frames per second), although rates as low as a few frames per second may work quite well, and rates as low as one frame per minute may be adequate for many purposes.
On slower instruments, general lock-in schemes or other tracking modalities, such as cardiac gating, can be used to remove motion artifacts due to breathing or heart beat.
Frame rate may also be variable, depending on the number of wavelengths and the complexity of the diagnostic procedure.
Preferably, the instrument can operate in multispectral, and hyperspectral, or even ultraspectral imaging modes. Multispectral modes involve image processing derived from a relatively small number of spectral image planes (two wavelengths to about twenty wavelengths). Hyperspectral and ultra spectral imaging modes involve at least twenty image planes and can produce significantly more accurate and informative results.
Ultraspectral modes involve hundreds of wavelengths, and may be able to produce even further information about the patient. Hyptrspectral and ultraspectral imaging may include selecting specific wavelength bands for discrunination of a particular diseased states, or it may also allow the instrument to scan for multiple conditions at the same time.
It is also contemplated that both types of instrument can operate in connection with an excitation source, such as an ultraviolet lamp and IR source, or other means of spectral illumination or a laser to enhance the received images. Although such excitation may not be necessary, it may allow for the examination of different optical phenomenon and provide additional diagnostic information. And both emission and reflectance modes can be combined in a diagnostic procedure either simultaneously or sequentially. Relative utilization of different emission or reflection measurements involved in the same diagnostic procedure can be obtained by modulating the different sources. The instrument can also develop light from bioluminescent sources introduced.into the patient.
Instruments according to the invention can also operate to process images from image planes acquired at wavelengths outside of the visible region. In one particular embodiment, the instrument is sensitive to the visible and near infra-red regions. It is also contemplated that far infra-red be included to allow the instrument to sense molecular-specific rotational modes.
An example of operation would include the use of a diagnostic protocol module that examined a first wavelength of about S50 and a second wavelength of about 575 associated with oxy- and deoxy-hemoglobin to determine blood oxygenation. The relationship between these wavelengths is described in "Hemoglobin: Molecular Genetics and Clinical Aspects," by H.
Franklin Bunn and Bernard Forget, W. B. Sanders, 1986. Another example would include the use of a diagnostic protocol module for examining the Fourier transform infra-red spectra of the colon and rectum as described in "Human Colorectal Cancers Display Abnormal Fourier Transform Spectra, " by Basil Rigas et al., Proceedings of the National Academy of Science, pp.
8140-8144, 1987.
Surgical and medical applications of instruments according to the invention can include, but are not limited to, determining tissue viability (i.e. whether tissue is dead or living tissue and whether it is predicted to remain living), detecting tissue ischemia (e.g., in heart, or in leg after a gunshot wound, differentiating between normal and malignant cells and tissues (e.g., delineating tumors, dysplasias and precaucerous tissue, detecting metastasis), differentiating between of infected and normal (but inflamed) tissue (e.g., extent of aortic root infection), quantification and identification of pathogens, (e.g., bacterial count of burn wounds and differentiating and delineating other pathologic states. Application can also include tissue, blood chemistry, and blood flow (including oxy- and deoxyhemoglobin, myoglobin deoxymyoglobin, cytochrome, pH, glucose, calcium and other elements or biological compounds alone or in combination). The instrument can also be applied by veterinarians to animals and by dentists to dental applications, such as peridental disease.
The present invention has now been described in connection with a number of specific embodiments thereof. However, numerous modifications which are contemplated as falling within the scope of the present invention should now be apparent to those skilled in the art.
Therefore, it is intended that the scope of the present invention be limited only by the scope of the claims appended hereto. In addition, the order of presentation of the claims should not be construed to limit the scope of any particular term in the claims.
What is claimed is:
Claims (82)
PROPERTY OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:
1. A medical instrument comprising:
a first-stage optic responsive to illumination of a viable tissue surface of a patient;
a spectral separator optically responsive to the first stage optic and having a control input;
an imaging sensor optically responsive to the spectral separator and having an image data output;
a diagnostic processor having an image acquisition interface with an input responsive to the imaging sensor;
a filter control interface having a control output provided to the control input of the spectral separator, which directs the spectral separator independently of the illumination to receive wavelengths of the illumination that provide multispectral or hyperspectral information as determined by a set of instructions from a diagnostic protocol module;
a general-purpose operating module, and a plurality of diagnostic protocol modules, wherein each diagnostic protocol module is organ or tissue specific and contains the set of instructions for operating the spectral separator via the filter control interface and for operating the image acquisition interface.
a first-stage optic responsive to illumination of a viable tissue surface of a patient;
a spectral separator optically responsive to the first stage optic and having a control input;
an imaging sensor optically responsive to the spectral separator and having an image data output;
a diagnostic processor having an image acquisition interface with an input responsive to the imaging sensor;
a filter control interface having a control output provided to the control input of the spectral separator, which directs the spectral separator independently of the illumination to receive wavelengths of the illumination that provide multispectral or hyperspectral information as determined by a set of instructions from a diagnostic protocol module;
a general-purpose operating module, and a plurality of diagnostic protocol modules, wherein each diagnostic protocol module is organ or tissue specific and contains the set of instructions for operating the spectral separator via the filter control interface and for operating the image acquisition interface.
2. The medical instrument of claim 1, wherein the spectral separator is a filter.
3. The medical instrument of claim 1, wherein the imaging sensor is a two-dimensional imaging array.
4. The medical instrument of claim 1, wherein the imaging sensor comprises a charge coupled device.
5. The medical instrument of claim 1, wherein the imaging sensor comprises an infra-red sensitive focal plane array.
6. The medical instrument of claim 1, further comprising a memory for storing the image data acquired from the image sensor.
7. The medical instrument of claim 1, wherein the first-stage optic is a macro lens.
8. The medical instrument of claim 1, wherein the first stage optic is an adjustable lens.
9. The medical instrument of claim 1, further comprising a stand connected relative to the first-stage optic to position the first-stage optic relative to the patient.
10. The medical instrument of claim 1, further comprising:
a probe; and an imaging fiber optic cable.
a probe; and an imaging fiber optic cable.
11. The medical instrument of claim 10, further comprising a surgical implement attached to the probe.
12. The medical instrument of claim 1, wherein the filter control interface is operable to adjust the spectral separator at least two times to acquire multispectral data for redisplay in real time.
13. The medical instrument of claim 1, wherein the set of instructions in each of the diagnostic protocol modules comprises an image processing protocol, wherein the general-purpose operating module is operative to instruct the spectral separator to successively collect a plurality of images from the patient, wherein the general-purpose operating module is operative to acquire from the imaging sensor the plurality of images, and wherein the general-purpose operating module is operative to process the acquired plurality of images according to the diagnostic processing protocol to obtain a processed display image.
14. The medical instrument of claim 13, wherein the general-purpose operating module is operative to generate a processed display image between one time a second and thirty times a second.
15. The medical instrument of claim 14, wherein the general-purpose operating module is operative to generate a processed display image within about one minute.
16. The medical instrument of claim 14, wherein the general-purpose operating module is operative to acquire some images within different time constraints depending on a number of wavelengths, and a complexity of the diagnostic protocols.
17. The medical instrument of claim 1, wherein the set of instructions in each of the diagnostic protocol modules comprises a predetermined image processing protocol adapted to detect particular characteristics of one or more types of tissue, organ disease or trauma, wherein the general-purpose operating module is operative to instruct the spectral separator to collect a plurality of images from the patient, wherein the general-purpose operating module is operative to acquire from the imaging sensor the plurality of images collected, and wherein the general-purpose operating module is operative to process the acquired images according to the diagnostic processing protocol to obtain a processed display image.
18. The medical instrument of claim 1, wherein the diagnostic processor comprises a real-time processor operative to generate a processed display image between one time a second and thirty times a second.
19. The medical instrument of claim 1, wherein the diagnostic processor is operable to perform diagnostic processing for images acquired from a source that comprises visible light.
20. The medical instrument of claim 1, wherein the filter and sensor are operable in the visible and far infra-red regions.
21. The medical instrument of claim 1, wherein the filter and sensor are operable in the ultra-violet, visible, and infra-red regions.
22. The medical instrument of claim 1, wherein the diagnostic processor performs spectral data processing.
23. The medical instrument of claim 1, wherein the diagnostic processor is modular and upgradeable by adding additional diagnostic protocol modules, thereby expanding diagnostic capabilities.
24. The medical instrument of claim 1, further comprising a supplemental light source.
25. The medical instrument of claim 24, wherein both light emission and reflectance modes are combined in a diagnostic procedure either simultaneously or sequentially.
26. The medical instrument of claim 1, wherein the imaging sensor is a charged-coupled device.
27. The medical instrument of claim 1, wherein the imaging processor provides processed images to the image output device between one time a second and thirty times a second.
28. A method for acquiring an image, comprising the steps of:
receiving light at a first-stage optic collected from a viable tissue of a patient;
transmitting the light using the first-stage optic through a spectral separator, wherein the spectral separator has a control input;
removing all of the light except for a wavelength region of interest in the spectral separator, wherein the remaining light is spectrally resolved light;
transmitting the spectrally resolved light to an imaging sensor, wherein the imaging sensor has an image data output;
generating an image signal;
outputting the image signal to a diagnostic processor; and acquiring the image signal at the diagnostic processor, wherein the diagnostic processor has an image acquisition interface with an input responsive to the imaging sensor, a filter control interface having a control output provided to the control input of the spectral separator, which directs the spectral separator independently of the illumination to receive multiple selected wavelengths of the illumination that provides multispectral or hyperspectral information as determined by a set of instructions from one or more diagnostic protocol modules, a general-purpose operating module, wherein each diagnostic protocol module is organ specific disease specific, trauma specific or tissue specific and contains a set of instructions for operating the spectral separator via the filter control interface and for operating the image acquisition interface.
receiving light at a first-stage optic collected from a viable tissue of a patient;
transmitting the light using the first-stage optic through a spectral separator, wherein the spectral separator has a control input;
removing all of the light except for a wavelength region of interest in the spectral separator, wherein the remaining light is spectrally resolved light;
transmitting the spectrally resolved light to an imaging sensor, wherein the imaging sensor has an image data output;
generating an image signal;
outputting the image signal to a diagnostic processor; and acquiring the image signal at the diagnostic processor, wherein the diagnostic processor has an image acquisition interface with an input responsive to the imaging sensor, a filter control interface having a control output provided to the control input of the spectral separator, which directs the spectral separator independently of the illumination to receive multiple selected wavelengths of the illumination that provides multispectral or hyperspectral information as determined by a set of instructions from one or more diagnostic protocol modules, a general-purpose operating module, wherein each diagnostic protocol module is organ specific disease specific, trauma specific or tissue specific and contains a set of instructions for operating the spectral separator via the filter control interface and for operating the image acquisition interface.
29. The method of claim 28, wherein the spectral separator is a filter.
30. The method of claim 28, wherein the imaging sensor is a two-dimensional imaging array.
31. The method of claim 28, wherein the imaging sensor comprises an infra-red sensitive focal plane array.
32. The method of claim 28, further comprising the steps of storing the image data acquired from the image sensor.
33. The method of claim 28, wherein the first-stage optic is a macro lens.
34. The method of claim 28, wherein the first-stage optic is an adjustable lens.
35. The method of claim 28, wherein the first-stage optic is disposed in a probe that comprises an imaging fiber optic cable.
36. The method of claim 35, wherein the probe is a surgical instrument.
37. The method of claim 28, further comprising the step of operating the control interface to adjust the filter at least two times to acquire multispectral data for redisplay in real-time.
38. The method of claim 28, further comprising the steps of:
instructing the spectral separator to successively collect a plurality of images from the patient, wherein the set of instructions in each of the diagnostic protocol modules comprises an image processing protocol;
acquiring from the imaging sensor the plurality of images of the collected light; and processing the acquired images according to the diagnostic processing protocol to obtain a processed display image.
instructing the spectral separator to successively collect a plurality of images from the patient, wherein the set of instructions in each of the diagnostic protocol modules comprises an image processing protocol;
acquiring from the imaging sensor the plurality of images of the collected light; and processing the acquired images according to the diagnostic processing protocol to obtain a processed display image.
39. The method of claim 38, further comprising the step of generating a processed display image between one time a second and thirty times a second.
40. The method of claim 38, wherein the general-purpose operating module is a processor operative to generate a processed display image within about one minute.
41. The method of claim 38, wherein the general-purpose operating module is operative to acquire some images within different time constraints depending on a number of wavelengths, and a complexity of the diagnostic protocols.
42. The method of claim 28, further comprising the steps of:
instructing the spectral separator to successively collect a plurality of images from the patient, wherein the set of instructions in each of the diagnostic protocol modules comprises a predetermined image processing protocol adapted to detect particular characteristics of the one or more types of tissues;
acquiring from the imaging sensor the plurality of images of the collected light; and processing the acquired images according to the diagnostic processing protocol to obtain a processed display image.
instructing the spectral separator to successively collect a plurality of images from the patient, wherein the set of instructions in each of the diagnostic protocol modules comprises a predetermined image processing protocol adapted to detect particular characteristics of the one or more types of tissues;
acquiring from the imaging sensor the plurality of images of the collected light; and processing the acquired images according to the diagnostic processing protocol to obtain a processed display image.
43. The method of claim 28, wherein the diagnostic processor comprises a real-time processor operative to generate a processed display image between one time a second and thirty times a second.
44. The method of claim 28, wherein the diagnostic processor is operable to perform diagnostic processing for images acquired from a source that comprises visible light.
45. The method of claim 28, wherein the filter and sensor are operable in the visible and far infra-red regions.
46. The method of claim 28, wherein the filter and sensor are operable in the ultra-violet, visible, and infra-red regions.
47. The method of claim 28, further comprising the step of:
selecting a diagnostic protocol module from a plurality of diagnostic protocol modules, wherein the selected diagnostic protocol is adapted to detect particular characteristics of one or more types of tissue.
selecting a diagnostic protocol module from a plurality of diagnostic protocol modules, wherein the selected diagnostic protocol is adapted to detect particular characteristics of one or more types of tissue.
48. The method of claim 28, wherein the diagnostic processor is operable to perform diagnostic processing for images acquired from a supplemental light source which may filter to emphasize particular special characteristics of the light it emits.
49. The method of claim 28, wherein the diagnostic processor performs statistical techniques to compute an image.
50. The method of claim 28, wherein the diagnostic processor is modular and upgradeable by adding additional diagnostic protocol modules, thereby expanding diagnostic capabilities.
51. The method of claim 28, further comprising the step of generating light from a supplemental light source.
52. The method of claim 28, wherein both light emission and reflectance modes are combined in a diagnostic procedure either simultaneously or sequentially.
53. The method of claim 28, wherein the diagnostic protocol performs tissue oxygenation mapping.
54. The method of claim 28, wherein the diagnostic protocol performs tissue viability mapping.
55. The method of claim 28, wherein the diagnostic protocol performs a diagnosis of normal versus abnormal tissue.
56. The method of claim 28, wherein the diagnostic protocol performs tissue ischemia detection.
57. The method of claim 28, wherein the diagnostic protocol performs cancer detection or diagnosis.
58. A multi-spectral diagnostic imaging method comprising the steps of:
collecting broad-band light from a viable tissue surface of a patient;
acquiring a number of images, wherein said number is equal to or greater than two;
and each image is acquired by an acquisition method comprising the step of:
applying a filter to filter out all but a particular region of interest from the light collected from said patient surface;
specifying said region of interest according to a diagnostic protocol, wherein said diagnostic protocol is adapted to detect characteristics of said patient surface area, independently of the wavelength of illumination to provide multispectral or hyperspectral information as determined by a set of instructions from the diagnostic protocol module; and processing said number images to obtain a display image.
collecting broad-band light from a viable tissue surface of a patient;
acquiring a number of images, wherein said number is equal to or greater than two;
and each image is acquired by an acquisition method comprising the step of:
applying a filter to filter out all but a particular region of interest from the light collected from said patient surface;
specifying said region of interest according to a diagnostic protocol, wherein said diagnostic protocol is adapted to detect characteristics of said patient surface area, independently of the wavelength of illumination to provide multispectral or hyperspectral information as determined by a set of instructions from the diagnostic protocol module; and processing said number images to obtain a display image.
59. The method of claim 58, wherein said light is selected from the group consisting of: infra-red, ultraviolet, visible, and any combination thereof.
60. The method of claim 58, wherein said particular wavelength regions of interest are not identical.
61. The method of claim 58, wherein said number is equal to or greater than twenty.
62. The method of claim 58, wherein said number is equal to or greater than one hundred.
63. The method of claim 58, further comprising the step of adjusting said area to collect light from larger or smaller patient tissue surface areas.
64. The method of claim 58, wherein said processing step comprises, alternatively, the step of. combining said number of images; comparing relative amplitudes of the collected light at different wavelengths; adding amplitudes of the collected light at different wavelengths; or performing statistical techniques.
65. The method of claim 64, further comprising the step of: displaying said display image; storing said display image; or printing said display image.
66. The method of claim 58, wherein said processing step is based on a diagnostic knowledge base.
67. The method of claim 58, further comprising the step of exciting said patient surface area with an excitation source, wherein said excitation source is an ultraviolet lamp, infra-red source, laser, or other means of spectral illumination.
68. The method of claim 58, wherein said characteristics are selected from the group consisting of: tissue viability, tissue ischemia, malignancy, infection, pathology, blood chemistry, blood flow, and any combination thereof.
69. A diagnostic processor configured to control acquisition, processing and display of images, comprising:
a source for illuminating a viable tissue;
a plurality of diagnostic protocol modules comprising instructions for the acquisition and processing of images that provide hyperspectral or multispectral information, wherein the diagnostic protocol modules are tissue specific, organ specific, disease specific or trauma specific;
a user input for allowing a user to select a diagnostic protocol module from the plurality of diagnostic protocol modules;
a spectral separator configured to filter broad-band light reflected or emitted from the viable tissue, wherein the spectral separator is controlled by instructions from the selected diagnostic protocol module, and further wherein the spectral separator is operated independently of a wavelength of the source;
an imaging sensor configured to collect light filtered by the spectral separator, wherein the imaging sensor is controlled by instructions from the selected diagnostic protocol module;
an image processor configured to process images collected by the imaging sensor, wherein the image processor is controlled by instructions from the selected diagnostic protocol module; and an image output device for providing output of the hyperspectral or multispectral information from the image processor.
a source for illuminating a viable tissue;
a plurality of diagnostic protocol modules comprising instructions for the acquisition and processing of images that provide hyperspectral or multispectral information, wherein the diagnostic protocol modules are tissue specific, organ specific, disease specific or trauma specific;
a user input for allowing a user to select a diagnostic protocol module from the plurality of diagnostic protocol modules;
a spectral separator configured to filter broad-band light reflected or emitted from the viable tissue, wherein the spectral separator is controlled by instructions from the selected diagnostic protocol module, and further wherein the spectral separator is operated independently of a wavelength of the source;
an imaging sensor configured to collect light filtered by the spectral separator, wherein the imaging sensor is controlled by instructions from the selected diagnostic protocol module;
an image processor configured to process images collected by the imaging sensor, wherein the image processor is controlled by instructions from the selected diagnostic protocol module; and an image output device for providing output of the hyperspectral or multispectral information from the image processor.
70. The diagnostic processor of claim 69, wherein one or more of the diagnostic protocol modules comprise instructions that the image processor process multispectral images.
71. The diagnostic processor of claim 69, wherein one or more of the diagnostic protocol modules comprise instructions that the image processor process hyperspectral images.
72. The diagnostic processor of claim 69, wherein one or more of the diagnostic protocol modules comprise instructions that the image processor process ultraspectral images.
73. The diagnostic processor of claim 69, wherein one or more of the diagnostic protocol modules comprise instructions for the display of images.
74. A method of imaging a tissue comprising:
illuminating a tissue;
selecting a diagnostic protocol module from a diagnostic processor, wherein the diagnostic processor comprises a plurality of tissue-specific, organ-specific, disease specific or trauma specific diagnostic protocol modules, further wherein the diagnostic protocol modules comprise instructions for the acquisition and processing of images;
filtering broad-band light reflected and/or emitted from the tissue using a spectral separator controlled by instructions from the selected diagnostic protocol module, wherein the spectral separator is operated independent of the illumination wavelength;
collecting the light passed by the spectral separator with an imaging sensor, wherein the imaging sensor is controlled by the selected diagnostic protocol module;
processing images collected by the imaging sensor with an image processor, wherein the image processor is controlled by instructions from the selected diagnostic protocol module; and displaying one or more processed images.
illuminating a tissue;
selecting a diagnostic protocol module from a diagnostic processor, wherein the diagnostic processor comprises a plurality of tissue-specific, organ-specific, disease specific or trauma specific diagnostic protocol modules, further wherein the diagnostic protocol modules comprise instructions for the acquisition and processing of images;
filtering broad-band light reflected and/or emitted from the tissue using a spectral separator controlled by instructions from the selected diagnostic protocol module, wherein the spectral separator is operated independent of the illumination wavelength;
collecting the light passed by the spectral separator with an imaging sensor, wherein the imaging sensor is controlled by the selected diagnostic protocol module;
processing images collected by the imaging sensor with an image processor, wherein the image processor is controlled by instructions from the selected diagnostic protocol module; and displaying one or more processed images.
75. The method of claim 74, wherein the step of illuminating the viable tissue comprises illumination with an unfiltered light.
76. The method of claim 74, wherein the step of illuminating the viable tissue comprises illumination with filtered light.
77. The method of claim 74, wherein the filtering of the spectral separator is independent of the illumination wavelength.
78. The method of claim 74, wherein the step of processing images comprises multispectrally processing images.
79. The method of claim 74, wherein the step of processing images comprises hyperspectrally processing images.
80. The method of claim 74, wherein the step of processing images comprises ultraspectrally processing images.
81. A medical instrument comprising:
a first-stage optic responsive to illumination of a tissue surface of a patient;
a spectral separator optically responsive to the first stage optic and having a control input;
a second stage optic for receiving light from the spectral separator and focusing the light;
a two-dimensional imaging sensor for receiving the focused light from the second stage optic, the image sensor having an image data output;
a diagnostic processor having an image acquisition interface with an input responsive to the imaging sensor; and a filter control interface having a control output provided to the control input of the spectral separator.
a first-stage optic responsive to illumination of a tissue surface of a patient;
a spectral separator optically responsive to the first stage optic and having a control input;
a second stage optic for receiving light from the spectral separator and focusing the light;
a two-dimensional imaging sensor for receiving the focused light from the second stage optic, the image sensor having an image data output;
a diagnostic processor having an image acquisition interface with an input responsive to the imaging sensor; and a filter control interface having a control output provided to the control input of the spectral separator.
82. The medical instrument of claim 81, wherein the spectral separator is a liquid crystal tunable filter.
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US8024027B2 (en) | 1998-09-03 | 2011-09-20 | Hyperspectral Imaging, Inc. | Infrared endoscopic balloon probes |
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AU5908000A (en) * | 1999-07-02 | 2001-01-22 | Hypermed Imaging, Inc. | Imaging apparatus with means for fusing thermal and hyperspectral images |
US6709387B1 (en) * | 2000-05-15 | 2004-03-23 | Given Imaging Ltd. | System and method for controlling in vivo camera capture and display rate |
EP1719448B1 (en) * | 2004-02-24 | 2012-08-29 | Waseda University | Method of measuring superficial chemical species and apparatus for measuring the same |
US8548570B2 (en) * | 2004-11-29 | 2013-10-01 | Hypermed Imaging, Inc. | Hyperspectral imaging of angiogenesis |
WO2006086085A2 (en) * | 2004-12-28 | 2006-08-17 | Hypermed, Inc. | Hyperspectral/multispectral imaging in determination, assessment and monitoring of systemic physiology and shock |
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JP4575474B2 (en) * | 2008-06-11 | 2010-11-04 | 国立大学法人東京工業大学 | Biological tissue identification apparatus and method |
CN102612338B (en) | 2009-11-20 | 2016-05-04 | 基文影像公司 | For the system and method for the power consumption of device in control volume |
US8988680B2 (en) | 2010-04-30 | 2015-03-24 | Chemimage Technologies Llc | Dual polarization with liquid crystal tunable filters |
JP5974174B2 (en) * | 2013-03-19 | 2016-08-23 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | System for performing hyperspectral imaging with visible light, and method for recording a hyperspectral image and displaying the hyperspectral image with visible light |
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IL108350A0 (en) * | 1993-01-19 | 1994-04-12 | Computer Aided Medical Inc | Diagnostic imaging method and device |
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JPH03264042A (en) | Endoscope device |
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Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |
Effective date: 20181030 |