CA2258077C - Hydrophilic interpenetrating polymer network coating for medical devices - Google Patents
Hydrophilic interpenetrating polymer network coating for medical devices Download PDFInfo
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- CA2258077C CA2258077C CA002258077A CA2258077A CA2258077C CA 2258077 C CA2258077 C CA 2258077C CA 002258077 A CA002258077 A CA 002258077A CA 2258077 A CA2258077 A CA 2258077A CA 2258077 C CA2258077 C CA 2258077C
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- elongate shaft
- medical device
- block copolymer
- isocyanate
- styrene
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/04—Macromolecular materials
- A61L29/041—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/04—Macromolecular materials
- A61L29/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
- C08J7/04—Coating
- C08J7/056—Forming hydrophilic coatings
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2353/00—Characterised by the use of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives of such polymers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2387/00—Characterised by the use of unspecified macromolecular compounds, obtained otherwise than by polymerisation reactions only involving unsaturated carbon-to-carbon bonds
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- Animal Behavior & Ethology (AREA)
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- Veterinary Medicine (AREA)
- Polymers & Plastics (AREA)
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Abstract
Method for the manufacture of a medical device which presents a hydrophilic surface coated elongate shaft for insertion into a body passageway comprising the steps of having the elongate shaft formed from a thermoplastic elastomer material selected from the group consisting of a polyether block amide and a styrene block copolymer and forming the hydrophilic coating on the elongate shaft by applying sequentially to the surface of the elongate shaft a solution comprising between 0.05 to 40 9'0 (weight to volume) of an isocyanate compound and a solution containing between 0.5 % and 50 % (weight to volume) of polyvinylpyrrolidone and curing at an elevated temperature.
Description
HYDROPHILIC INTERPENETRATING POLYMER NETWORK COAT~TG FOR
MEDICAL DEVICES
The present invention relates to medical devices which present an elongate shaft hang an outer surface coating for insertion into a passageway in a human or animal body and is principally, but not exclusively, concerned with surface coated catheters:
Many medical devices incorporate elongate shafts such as tubes which are intended for insertion into and through passageways of a living body such as those of the urethral tract and the cardiovascular system. The most common type of this general grouping of medical ~o devices are known as catheters. Exemplary catheters include those designated for urological, angioplasty and valwloplasty uses, that is, adapted respectively for insertion into the urethra, the lumen of a blood vessel and heart passageway of a living body, normally a human body.
is Because of the intended use of such medical devices certain parameters need to be satisfied by the material from which the elongate shaft is manufactured. The material must fulfil such requirements as softness, good kink resistance, good dimensional stability, processability, for example ease to form and glue, and the possibility to be sterilised by radiation, steam, ethylene oxide or other means. There is further the need for the material to accept a surface Zo treatment which will impart desired surface properties to the medical device such as lubricity, hydrophilicity and blood compatibility. To this latter end, the chemistry of the substrate material is critical since this affects the possibility to coat the substrate.
For many years now polyvinyl chloride (PVC) has been used to manufacture medical Zs devices having elongate shafts for insertion into a body passageway such as catheters due to PVC fulfilling the requirements mentioned in the preceding paragraph.
For instance, prior European patent application publication No. 0493093 (Astra Meditec AB) makes known a process for manufacturing a PVC urinary catheter having a hydrophilic so outer surface coating which exhibits a low coefficient of friction when wetted. The process involves forming a hydrophilic surface coating on the PVC catheter by sequentially applying
MEDICAL DEVICES
The present invention relates to medical devices which present an elongate shaft hang an outer surface coating for insertion into a passageway in a human or animal body and is principally, but not exclusively, concerned with surface coated catheters:
Many medical devices incorporate elongate shafts such as tubes which are intended for insertion into and through passageways of a living body such as those of the urethral tract and the cardiovascular system. The most common type of this general grouping of medical ~o devices are known as catheters. Exemplary catheters include those designated for urological, angioplasty and valwloplasty uses, that is, adapted respectively for insertion into the urethra, the lumen of a blood vessel and heart passageway of a living body, normally a human body.
is Because of the intended use of such medical devices certain parameters need to be satisfied by the material from which the elongate shaft is manufactured. The material must fulfil such requirements as softness, good kink resistance, good dimensional stability, processability, for example ease to form and glue, and the possibility to be sterilised by radiation, steam, ethylene oxide or other means. There is further the need for the material to accept a surface Zo treatment which will impart desired surface properties to the medical device such as lubricity, hydrophilicity and blood compatibility. To this latter end, the chemistry of the substrate material is critical since this affects the possibility to coat the substrate.
For many years now polyvinyl chloride (PVC) has been used to manufacture medical Zs devices having elongate shafts for insertion into a body passageway such as catheters due to PVC fulfilling the requirements mentioned in the preceding paragraph.
For instance, prior European patent application publication No. 0493093 (Astra Meditec AB) makes known a process for manufacturing a PVC urinary catheter having a hydrophilic so outer surface coating which exhibits a low coefficient of friction when wetted. The process involves forming a hydrophilic surface coating on the PVC catheter by sequentially applying
2 a solution containing between 0.05-40% (weightlvolume, that is, kg/1) of an isocyanate compound and a solution of polyvinylpyrrolidone (PVP) containing between 0.5-50%
(weight/volume) to the outer surface of the catheter, for example by dipping, and then curing the hydrophilic coating at an elevated temperature advantageously in the presence of a water-containing gas such as ambient air.
The suitability of PVC for medical devices such as catheters, however, is now being questioned on environmental grounds and further because of the toxicity of the plasticisers added to PVC. Moreover, coating PVC catheters by, for example, the process of European patent application publication No. 0093093 results in an appreciable shrinkage of the PVC
catheters in the longitudinal direction, typically 6-7% of the original length, due to the operating temperatures used in the coating process. The obvious disadvantage of such appreciable shrinkage is the wastage of material in the sense that PVC
catheters of longer length than finally required have to be used to account for the shrinkage. In addition, is quality control of the coating process is made more complicated than would be ideal by this marked degree of shrinkage.
There is therefore a need for a medical device which presents a hydrophilic surface coated non-PVC elongate shaft for insertion into a body passageway which experiences no zo appreciable shrinkage on application of the hydrophilic surface coating.
To this end, the present invention provides a method for the manufacture of a medical device which presents a hydrophilic surface coated elongate shaft for insertion into a body passageway comprising the steps of having the elongate shaft formed from a thermoplastic zs elastomer material selected from the group consisting of a polyether block amide and a styrene block copolymer and forming the hydrophilic coating on the elongate shaft by applying sequentially to the surface of the elongate shaft a solution comprising between 0.05 to 40% (weight to volume) of an isocyanate compound and a solution containing between 0.5 and 50% (weight to volume) of polyvinylpyrrolidone and curing at an elevated 3o temperature.
(weight/volume) to the outer surface of the catheter, for example by dipping, and then curing the hydrophilic coating at an elevated temperature advantageously in the presence of a water-containing gas such as ambient air.
The suitability of PVC for medical devices such as catheters, however, is now being questioned on environmental grounds and further because of the toxicity of the plasticisers added to PVC. Moreover, coating PVC catheters by, for example, the process of European patent application publication No. 0093093 results in an appreciable shrinkage of the PVC
catheters in the longitudinal direction, typically 6-7% of the original length, due to the operating temperatures used in the coating process. The obvious disadvantage of such appreciable shrinkage is the wastage of material in the sense that PVC
catheters of longer length than finally required have to be used to account for the shrinkage. In addition, is quality control of the coating process is made more complicated than would be ideal by this marked degree of shrinkage.
There is therefore a need for a medical device which presents a hydrophilic surface coated non-PVC elongate shaft for insertion into a body passageway which experiences no zo appreciable shrinkage on application of the hydrophilic surface coating.
To this end, the present invention provides a method for the manufacture of a medical device which presents a hydrophilic surface coated elongate shaft for insertion into a body passageway comprising the steps of having the elongate shaft formed from a thermoplastic zs elastomer material selected from the group consisting of a polyether block amide and a styrene block copolymer and forming the hydrophilic coating on the elongate shaft by applying sequentially to the surface of the elongate shaft a solution comprising between 0.05 to 40% (weight to volume) of an isocyanate compound and a solution containing between 0.5 and 50% (weight to volume) of polyvinylpyrrolidone and curing at an elevated 3o temperature.
3 The use of a polyether block amide or a styrene block copolymer results in an elongate shaft which undergoes substantially no shrinkage in the longitudinal direction as compared to PVC on application of the hydrophilic coating as well as providing an elongate shaft with the normal properties required for insertion thereof into a body passageway.
The present invention therefore enables a catheter to be provided which addresses the aforementioned disadvantages of PVC based catheters leading to inter alia less wastage of starting materials and the possibility to use TV monitors for quality control.
While the background section of prior European patent application publication No.
io 0566755 (Cordis Corp.) makes it known that the use of a polyether block amide in the manufacture of medical device tubing intended for insertion into a body passageway is known per se, European patent application publication No. 0566755 goes on to teach that undesirable blooming develops in such tubing material after it has been stored for a length of time which can interfere with the adherence of a coating thereto, for example a coating is for imparting lubricity to the tubing. The solution to the blooming problem according to European patent application publication No. 0566755 is to blend the polyether block amide with a polyetheramide component having substantially no ester linkages.
No such problem with adherence of the hydrophilic coating to a polyether block amide 2o manifests itself when the method according to the present invention is followed despite the fact that blooming is sometimes observed after some months storage. This can be attributed to the manner in which the hydrophilic coating is applied to the elongate shaft in the method according to the invention.
is The polyether block amide used in the invention is believed to have a structure as follows:
HO-[-C-PA-C-O-PE-O-J~-H
O O
WO 97/49437 PCTlSE97/01121
The present invention therefore enables a catheter to be provided which addresses the aforementioned disadvantages of PVC based catheters leading to inter alia less wastage of starting materials and the possibility to use TV monitors for quality control.
While the background section of prior European patent application publication No.
io 0566755 (Cordis Corp.) makes it known that the use of a polyether block amide in the manufacture of medical device tubing intended for insertion into a body passageway is known per se, European patent application publication No. 0566755 goes on to teach that undesirable blooming develops in such tubing material after it has been stored for a length of time which can interfere with the adherence of a coating thereto, for example a coating is for imparting lubricity to the tubing. The solution to the blooming problem according to European patent application publication No. 0566755 is to blend the polyether block amide with a polyetheramide component having substantially no ester linkages.
No such problem with adherence of the hydrophilic coating to a polyether block amide 2o manifests itself when the method according to the present invention is followed despite the fact that blooming is sometimes observed after some months storage. This can be attributed to the manner in which the hydrophilic coating is applied to the elongate shaft in the method according to the invention.
is The polyether block amide used in the invention is believed to have a structure as follows:
HO-[-C-PA-C-O-PE-O-J~-H
O O
WO 97/49437 PCTlSE97/01121
4 wherein PA is a polyamide, PE is a polyether and n is an integer greater than I which represents the number of blocks of copolymer molecular repeating units within the molecular formula of the copolymer. Representative polyether block amide materials include the Pebax~ polymers (Elf Atochem S. A.).
In an embodiment of the invention the styrene block copolymer is a styrene-ethylene/butylene-styrene block copolymer, for example Evoprene~ G (Evode Plastics Ltd.).
io Application of the isocyanate solution to the elongate shaft surface results in a coating having unreacted isocyanate groups being formed on the elongate shaft surface.
Application of the polyvinylpyrrolidone solution to the elongate shaft surface then results in a hydrophilic polyvinylpyrrolidone-polyurea interpoiymer coating being formed on the elongate shaft surface. Curing of this hydrophilic coating binds the isocyanate compounds is together to form a stable non-reactive network that binds the hydrophilic polyvinylpyrrolidone. To advantage, curing takes place in the presence of a water-containing gas, for example ambient air, to enable the isocyanate groups to react with the water to yield an amine which rapidly reacts with other isocyanate groups to form a urea cross-link.
In an embodiment of the invention the method further comprises the steps of evaporating the solvent of the isocyanate solution prior to application of the polyvinyipyrrolidone solution and evaporating the solvent of the polyvinylpyrrolidone solution prior to curing of the hydrophilic coating. This may for example be done by air drying.
2s In an embodiment of the invention the isocyanate compound comprises at least two unreacted isocyanate groups per molecule. The isocyanate may be selected from 2,4-toluene diisocyanate and 4,4'-diphenylmethane diisocyanate, or a pentamer of hexamethylene diisocyanate and toluene diisocyanate of cyanurate type, or trimerized 3o hexamethylene diisocyanate biuret or mixtures thereof.
The solvent for the isocyanate compound is preferably one which does not react with isocyanate groups. The preferred solvent is methylene chloride but it is also possible to use ethyl acetate, acetone, chloroform, methyl ethyl ketone and ethylene dichloride, for s example.
The isocyanate solution may advantageously contain between 0.5 to 10% (weight to volume) of the isocyanate compound, and may preferably contain between 1 to 6%
(weight to volume) of the isocyanate compound. Generally, the isocyanate solution only needs to be ~o in contact with the surface briefly, for example S to 60 sec.
To enhance adherence of the hydrophilic coating to the elongate shaft surface the elongate shaft may be swelled beforehand in a suitable solvent. Another way is to choose a solvent for the isocyanate solution which has the ability to swell or dissolve the elongate shaft is surface which is to be coated.
In order to shorten the necessary reaction times and curing times suitable catalysts for isocyanate curing may be added. These catalysts may be dissolved in either the isocyanate solution or the polyvinylpyrrolidone solution but are preferably dissolved in the latter.
2o Different types of amines are especially useful, for example diamines, but also for example triethylenediamine. Preferably, an aliphatic amine is employed which is volatisable at the drying and curing temperatures used for the coating, and which furthermore is non-toxic.
Examples of suitable amines are N, N'diethylethylendiamine, hexamethylendiamine, ethylendiamine, paradiaminobenzene, 1,3-propandiol-para-aminobenzoic acid diester and 2s diaminobicyclo-octane.
Where the catalyst is in the polyvinylpyrrolidone solution, the proportion of catalyst in the solution is suitably between 0.1 to 50% by weight of the amount of polyvinyipyrrolidone, preferably between 0.1 to 10% by weight. Some of the above-mentioned amines, so particularly the diamines, can also react with isocyanate and thereby contribute to the cross-linking of the isocyanate compounds that give the desired strong adherence between the hydrophilic coating and the polymer surface.
The polyvinylpyrrolidone used preferably has a mean molecular weight of between I 04 to s 10~ with the most preferred mean molecular weight being about 105.
Polyvinylpyrrolidone having such a molecular weight is commercially available, for example under the trademark Kollidon~ (BASF). Examples of suitable solvents for polyvinylpyrrolidone that may be used are methylene chloride (preferred), ethyl acetate, acetone, chloroform, methyl ethyl ketone and ethylene dichloride. The proportion of polyvinylpyrrolidone in the solution is preferably io between 0.5 to 10% (weight to volume) and most preferred between 2 to 8%
(weight to volume). The polyvinylpyrrolidone in the solvent is applied by dipping, spraying or the like for a short period of time, e.g. during 5 to 50 sec.
Curing of the coating is preferably performed at a temperature of 50 to 130° C, in for is example an oven, for a duration of between 5 to 300 min.
According to the invention there is further provided a medical device which presents a hydrophilic surface coated elongate shaft for insertion into a body passageway manufactured by the method according to the invention.
According to the invention there is yet further provided a medical device which presents an elongate shaft for insertion into a body passageway, the elongate shaft being made from a polyether block amide or a styrene block copolymer and provided with a hydrophilic outer surface coating formed from an interpenetrating network of polyvinylpyrrolidone and 2s polyurea.
According to the invention there is additionally provided a medical device which presents an elongate shaft for insertion into a body passageway, the elongate shaft being made from a polyether block amide or a styrene block copolymer and provided with a polyvinyipyrrolidone hydrophilic outer surface coating having enhanced osmolality.
In an embodiment of the invention the hydrophilic coating contains an osmolality-increasing compound, for instance an inorganic salt selected from sodium and potassium chlorides, iodides, citrates and benzoates. The osmolality-increasing compound may be applied in the manner detailed in prior European patent application publication No. 0217771.
In an embodiment of the invention the medical device is a catheter, for example those io designated for urological, angioplasty and valvuloplasty uses or the like.
In this case, the polyether block amide or styrene block copolymer selected for the elongate shaft respectively has a hardness in the range 25 Sh D to 70 Sh D and 40 shore A to 70 shore D.
Where the medical device is a urinary catheter a hardness in the range 25 Sh D
to 45 Sh D
for polyether block amide and 40 shore A to 45 shore D for styrene block copolymer is is ideal with greater hardnesses being preferred for intravascular catheters.
According to the invention there is also provided the use of a styrene block copolymer in the manufacture of a medical device which presents an elongate shaft for insertion into a body passageway.
zo The invention will now be illustrated but not limited by the following examples.
Examine 1 zs A diisocyanate (named Desmodur II,) is dissolved in methylene chloride to a concentration of 2% (weight/volume). A urinary catheter formed exclusively or essentially exclusively from Pebax~ (hereinafter a "urinary Pebax~ catheter") with a hardness of 70 shore D is dipped in this solution for 15 seconds and is then dried at ambient temperature for 60 seconds. The catheter is then dipped for 1 second in a solution containing 6%
so (weight/volume) of polyvinylpyrrolidone (K90; mean molecular weight 360 000) dissolved in methylene chloride. The catheter is then allowed to dry at ambient temperature for 60 seconds and is finally cured for 50 minutes at 100 °C. The catheter is finally allowed to cool to room temperature and is then rinsed in water. The catheter has a slippery and adherent surface when wet.
s The experiment was repeated with variations in the dipping time in the isocyanate bath ranging from 5 seconds to 1 minute, but no advantage was obtained by increasing the dipping time.
~o Example 2 A diisocyanate (named Desmodur IL) is dissolved in ethyl acetate to a concentration of 2%
(weight/volume). A urinary Pebax~ catheter with a hardness of 35 shore D is dipped in this solution for 15 seconds and is then dried at ambient temperature for 60 seconds. The i5 catheter is then dipped for 1 second in a solution containing 6%
(weight/volume) of polyvinylpyrrolidone (K90; mean molecular weight 360 000) dissolved in ethyl lactate (50%) and ethyl acetate {50%). The catheter is then allowed to dry at ambient temperature for 60 seconds and is finally cured for 50 minutes at 80 °C. The catheter is finally allowed to cool to room temperature and is then rinsed in water. The catheter has a slippery and zo adherent surface when wet.
Eaamole 3 2s A diisocyanate (named Desmodur II,) is dissolved in methylene chloride (75%) and tri chloro ethylene (25%) to a concentration of 2% (weight/volume). A urinary Pebax~
catheter with a hardness of 63 shore D is dipped in this solution for 15 seconds and is then dried at ambient temperature for 60 seconds. The catheter is then dipped for 1 second in a solution containing 6% (weight/volume) of polyvinylpyrrolidone {K90; mean molecular so weight 360 000) dissolved in methylene chloride (75%) and tri chloro ethylene (25%). The catheter is then allowed to dry at ambient temperature for 60 seconds and is finally cured for 50 minutes at 100 °C. The catheter is finally allowed to cool to room temperature and is then rinsed in water. The catheter has a slippery and adherent surface when wet.
s Example 4 A diisocyanate (named Desmodur II,) is dissolved in ethyl acetate to a concentration of 2%
{weight/volurne). A urinary catheter manufactured from Evoprene~ G with a hardness of 65 shore A is dipped in this solution for 15 seconds and is then dried at ambient temperature io for 60 seconds. The catheter is then dipped for 1 second in a solution containing 6%
(weightlvolume) of polyvinylpyrrolidone (K90; mean molecular weight 360 000) dissolved in methylene chloride. The catheter is then allowed to dry at ambient temperature for 60 seconds and is finally cured for 50 minutes at 100 °C. The catheter is finally allowed to cool to room temperature and is then rinsed in water. The catheter has a slippery and adherent is surface when wet.
The urinary catheters prepared according to the examples show low fi7ction, good kink resistance, good dimension stability and possibility to be sterilised.
Moreover, the longitudinal shrinkage of the catheters as a result of the coating process was less than 1% of zo the original length.
While the examples refer to the manufacture of urinary catheters it is to be understood that the invention is not restricted to this sole application but is equally applicable to other forms of catheters and moreover other constructions falling within the broad class of medical Zs devices having an elongate shaft. adapted for insertion into a body passageway as whole, for instance transurethral devices for treating erectile dysfunction and wound drains for insertion into body passageways in the form of wound cavities.
In an embodiment of the invention the styrene block copolymer is a styrene-ethylene/butylene-styrene block copolymer, for example Evoprene~ G (Evode Plastics Ltd.).
io Application of the isocyanate solution to the elongate shaft surface results in a coating having unreacted isocyanate groups being formed on the elongate shaft surface.
Application of the polyvinylpyrrolidone solution to the elongate shaft surface then results in a hydrophilic polyvinylpyrrolidone-polyurea interpoiymer coating being formed on the elongate shaft surface. Curing of this hydrophilic coating binds the isocyanate compounds is together to form a stable non-reactive network that binds the hydrophilic polyvinylpyrrolidone. To advantage, curing takes place in the presence of a water-containing gas, for example ambient air, to enable the isocyanate groups to react with the water to yield an amine which rapidly reacts with other isocyanate groups to form a urea cross-link.
In an embodiment of the invention the method further comprises the steps of evaporating the solvent of the isocyanate solution prior to application of the polyvinyipyrrolidone solution and evaporating the solvent of the polyvinylpyrrolidone solution prior to curing of the hydrophilic coating. This may for example be done by air drying.
2s In an embodiment of the invention the isocyanate compound comprises at least two unreacted isocyanate groups per molecule. The isocyanate may be selected from 2,4-toluene diisocyanate and 4,4'-diphenylmethane diisocyanate, or a pentamer of hexamethylene diisocyanate and toluene diisocyanate of cyanurate type, or trimerized 3o hexamethylene diisocyanate biuret or mixtures thereof.
The solvent for the isocyanate compound is preferably one which does not react with isocyanate groups. The preferred solvent is methylene chloride but it is also possible to use ethyl acetate, acetone, chloroform, methyl ethyl ketone and ethylene dichloride, for s example.
The isocyanate solution may advantageously contain between 0.5 to 10% (weight to volume) of the isocyanate compound, and may preferably contain between 1 to 6%
(weight to volume) of the isocyanate compound. Generally, the isocyanate solution only needs to be ~o in contact with the surface briefly, for example S to 60 sec.
To enhance adherence of the hydrophilic coating to the elongate shaft surface the elongate shaft may be swelled beforehand in a suitable solvent. Another way is to choose a solvent for the isocyanate solution which has the ability to swell or dissolve the elongate shaft is surface which is to be coated.
In order to shorten the necessary reaction times and curing times suitable catalysts for isocyanate curing may be added. These catalysts may be dissolved in either the isocyanate solution or the polyvinylpyrrolidone solution but are preferably dissolved in the latter.
2o Different types of amines are especially useful, for example diamines, but also for example triethylenediamine. Preferably, an aliphatic amine is employed which is volatisable at the drying and curing temperatures used for the coating, and which furthermore is non-toxic.
Examples of suitable amines are N, N'diethylethylendiamine, hexamethylendiamine, ethylendiamine, paradiaminobenzene, 1,3-propandiol-para-aminobenzoic acid diester and 2s diaminobicyclo-octane.
Where the catalyst is in the polyvinylpyrrolidone solution, the proportion of catalyst in the solution is suitably between 0.1 to 50% by weight of the amount of polyvinyipyrrolidone, preferably between 0.1 to 10% by weight. Some of the above-mentioned amines, so particularly the diamines, can also react with isocyanate and thereby contribute to the cross-linking of the isocyanate compounds that give the desired strong adherence between the hydrophilic coating and the polymer surface.
The polyvinylpyrrolidone used preferably has a mean molecular weight of between I 04 to s 10~ with the most preferred mean molecular weight being about 105.
Polyvinylpyrrolidone having such a molecular weight is commercially available, for example under the trademark Kollidon~ (BASF). Examples of suitable solvents for polyvinylpyrrolidone that may be used are methylene chloride (preferred), ethyl acetate, acetone, chloroform, methyl ethyl ketone and ethylene dichloride. The proportion of polyvinylpyrrolidone in the solution is preferably io between 0.5 to 10% (weight to volume) and most preferred between 2 to 8%
(weight to volume). The polyvinylpyrrolidone in the solvent is applied by dipping, spraying or the like for a short period of time, e.g. during 5 to 50 sec.
Curing of the coating is preferably performed at a temperature of 50 to 130° C, in for is example an oven, for a duration of between 5 to 300 min.
According to the invention there is further provided a medical device which presents a hydrophilic surface coated elongate shaft for insertion into a body passageway manufactured by the method according to the invention.
According to the invention there is yet further provided a medical device which presents an elongate shaft for insertion into a body passageway, the elongate shaft being made from a polyether block amide or a styrene block copolymer and provided with a hydrophilic outer surface coating formed from an interpenetrating network of polyvinylpyrrolidone and 2s polyurea.
According to the invention there is additionally provided a medical device which presents an elongate shaft for insertion into a body passageway, the elongate shaft being made from a polyether block amide or a styrene block copolymer and provided with a polyvinyipyrrolidone hydrophilic outer surface coating having enhanced osmolality.
In an embodiment of the invention the hydrophilic coating contains an osmolality-increasing compound, for instance an inorganic salt selected from sodium and potassium chlorides, iodides, citrates and benzoates. The osmolality-increasing compound may be applied in the manner detailed in prior European patent application publication No. 0217771.
In an embodiment of the invention the medical device is a catheter, for example those io designated for urological, angioplasty and valvuloplasty uses or the like.
In this case, the polyether block amide or styrene block copolymer selected for the elongate shaft respectively has a hardness in the range 25 Sh D to 70 Sh D and 40 shore A to 70 shore D.
Where the medical device is a urinary catheter a hardness in the range 25 Sh D
to 45 Sh D
for polyether block amide and 40 shore A to 45 shore D for styrene block copolymer is is ideal with greater hardnesses being preferred for intravascular catheters.
According to the invention there is also provided the use of a styrene block copolymer in the manufacture of a medical device which presents an elongate shaft for insertion into a body passageway.
zo The invention will now be illustrated but not limited by the following examples.
Examine 1 zs A diisocyanate (named Desmodur II,) is dissolved in methylene chloride to a concentration of 2% (weight/volume). A urinary catheter formed exclusively or essentially exclusively from Pebax~ (hereinafter a "urinary Pebax~ catheter") with a hardness of 70 shore D is dipped in this solution for 15 seconds and is then dried at ambient temperature for 60 seconds. The catheter is then dipped for 1 second in a solution containing 6%
so (weight/volume) of polyvinylpyrrolidone (K90; mean molecular weight 360 000) dissolved in methylene chloride. The catheter is then allowed to dry at ambient temperature for 60 seconds and is finally cured for 50 minutes at 100 °C. The catheter is finally allowed to cool to room temperature and is then rinsed in water. The catheter has a slippery and adherent surface when wet.
s The experiment was repeated with variations in the dipping time in the isocyanate bath ranging from 5 seconds to 1 minute, but no advantage was obtained by increasing the dipping time.
~o Example 2 A diisocyanate (named Desmodur IL) is dissolved in ethyl acetate to a concentration of 2%
(weight/volume). A urinary Pebax~ catheter with a hardness of 35 shore D is dipped in this solution for 15 seconds and is then dried at ambient temperature for 60 seconds. The i5 catheter is then dipped for 1 second in a solution containing 6%
(weight/volume) of polyvinylpyrrolidone (K90; mean molecular weight 360 000) dissolved in ethyl lactate (50%) and ethyl acetate {50%). The catheter is then allowed to dry at ambient temperature for 60 seconds and is finally cured for 50 minutes at 80 °C. The catheter is finally allowed to cool to room temperature and is then rinsed in water. The catheter has a slippery and zo adherent surface when wet.
Eaamole 3 2s A diisocyanate (named Desmodur II,) is dissolved in methylene chloride (75%) and tri chloro ethylene (25%) to a concentration of 2% (weight/volume). A urinary Pebax~
catheter with a hardness of 63 shore D is dipped in this solution for 15 seconds and is then dried at ambient temperature for 60 seconds. The catheter is then dipped for 1 second in a solution containing 6% (weight/volume) of polyvinylpyrrolidone {K90; mean molecular so weight 360 000) dissolved in methylene chloride (75%) and tri chloro ethylene (25%). The catheter is then allowed to dry at ambient temperature for 60 seconds and is finally cured for 50 minutes at 100 °C. The catheter is finally allowed to cool to room temperature and is then rinsed in water. The catheter has a slippery and adherent surface when wet.
s Example 4 A diisocyanate (named Desmodur II,) is dissolved in ethyl acetate to a concentration of 2%
{weight/volurne). A urinary catheter manufactured from Evoprene~ G with a hardness of 65 shore A is dipped in this solution for 15 seconds and is then dried at ambient temperature io for 60 seconds. The catheter is then dipped for 1 second in a solution containing 6%
(weightlvolume) of polyvinylpyrrolidone (K90; mean molecular weight 360 000) dissolved in methylene chloride. The catheter is then allowed to dry at ambient temperature for 60 seconds and is finally cured for 50 minutes at 100 °C. The catheter is finally allowed to cool to room temperature and is then rinsed in water. The catheter has a slippery and adherent is surface when wet.
The urinary catheters prepared according to the examples show low fi7ction, good kink resistance, good dimension stability and possibility to be sterilised.
Moreover, the longitudinal shrinkage of the catheters as a result of the coating process was less than 1% of zo the original length.
While the examples refer to the manufacture of urinary catheters it is to be understood that the invention is not restricted to this sole application but is equally applicable to other forms of catheters and moreover other constructions falling within the broad class of medical Zs devices having an elongate shaft. adapted for insertion into a body passageway as whole, for instance transurethral devices for treating erectile dysfunction and wound drains for insertion into body passageways in the form of wound cavities.
Claims (21)
1. A method for the manufacture of a medical device which presents a hydrophilic surface coated elongate shaft for insertion into a body passageway comprising the steps of having the elongate shaft formed from a thermoplastic elastomer material selected from the group consisting of a polyether block amide and a styrene block copolymer and forming the hydrophilic coating on the elongate shaft by applying sequentially to the surface of the elongate shaft a solution comprising between 0.05 to 40% (weight to volume) of an isocyanate compound and a solution containing between 0.5 and 50% (weight to volume) of polyvinylpyrrolidone and curing at an elevated temperature.
2. A method according to claim 1, wherein the isocyanate compound comprises at least two unreacted isocyanate groups per molecule.
3. A method according to claim 1 or 2, wherein the solvent of the isocyanate solution is an organic solvent which does not react with isocyanate.
4. A method according to claim 1, 2 or 3, wherein the method further comprises the steps of evaporating the solvent of the isocyanate solution prior to application of the polyvinylpyrrolidone solution and evaporating the solvent of the polyvinylpyrrolidone solution prior to curing.
5. A method according to any one of claims 1 to 4, wherein the curing is carried out in the presence of a water-containing gas.
6. A method according to any one of claims 1 to 5, wherein the curing is carried out at a temperature of between about 50 and 130°C.
7. A method according to any one of claims 1 to 6, wherein the styrene block copolymer is a styrene-ethylene/butylene-styrene block copolymer.
8. A method according to any one of claims 1 to 6, wherein the polyether block amide selected for the elongate shaft has a hardness in the range of 25 Sh D to 70 Sh D.
9. A method according to claim 7, wherein the styrene-ethylene/butylene-styrene block copolymer selected for the elongate shaft has a hardness in the range of 40 Sh A to 70 Sh D.
10. A method according to any one of claims 1 to 9, wherein the isocyanate is selected from 2,4-toluene diisocyanate and 4,4'-diphenylmethane diisocyanate, a pentamer of hexamethylene diisocyanate and toluene diisocyanate of cyanurate type, trimerized hexamethylene diisocyanate biuret and mixtures thereof.
11. A method according to any one of claims 1 to 10, wherein the method further comprises the steps of applying to the hydrophilic coating a solution containing an osmolality-increasing compound and evaporating the solution containing the osmolality-increasing compound.
12. A method according to claim 11, wherein the osmolality-increasing compound is an inorganic salt selected from sodium and potassium chlorides, iodides, citrates and benzoates.
13. A medical device which presents a hydrophilic surface coated elongate shaft for insertion into a body passageway manufactured by the method according to any one of claims 1 to 12.
14. A medical device which presents an elongate shaft for insertion into a body passageway wherein the elongate shaft is made from a polyether block amide or a styrene block copolymer and provided with a hydrophilic outer surface coating formed from an interpenetrating network of polyvinylpyrrolidone and polyurea.
15. A medical device according to claim 14, wherein the styrene block copolymer is a styrene-ethylene/butylene-styrene block copolymer.
16. A medical device according to claim 14, wherein the elongate shaft is formed from a polyether block amide having a hardness in the range 25 Sh D to 70 Sh D.
17. A medical device according to claim 15, wherein the elongate shaft is formed from a styrene-ethylene/butylene-styrene block copolymer having a hardness in the range 40 Sh A to 70 Sh D.
18. A medical device according to any one of claims 14 to 17, wherein the hydrophilic coating further comprises an osmolality-increasing compound.
19. A medical device according to claim 18, wherein the osmolality-increasing compound is an inorganic salt selected from sodium and potassium chlorides, iodides, citrates and benzoates.
20. A medical device according to any one of claims 13 to 19, wherein the device is a catheter.
21. A medical device according to claim 20, wherein the device is a urinary catheter.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9602529-1 | 1996-06-26 | ||
| SE9602529A SE9602529D0 (en) | 1996-06-26 | 1996-06-26 | Medical device |
| PCT/SE1997/001121 WO1997049437A1 (en) | 1996-06-26 | 1997-06-19 | Medical device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2258077A1 CA2258077A1 (en) | 1997-12-31 |
| CA2258077C true CA2258077C (en) | 2006-10-10 |
Family
ID=37114310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002258077A Expired - Fee Related CA2258077C (en) | 1996-06-26 | 1997-06-19 | Hydrophilic interpenetrating polymer network coating for medical devices |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2258077C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3018168A1 (en) * | 2014-10-02 | 2016-05-11 | Sumitomo Rubber Industries Limited | Surface modification method and surface-modified elastic body |
-
1997
- 1997-06-19 CA CA002258077A patent/CA2258077C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3018168A1 (en) * | 2014-10-02 | 2016-05-11 | Sumitomo Rubber Industries Limited | Surface modification method and surface-modified elastic body |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2258077A1 (en) | 1997-12-31 |
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