CA2232813C - Animaux non humains transgeniques pouvant produire des anticorps heterologues - Google Patents

Animaux non humains transgeniques pouvant produire des anticorps heterologues Download PDF

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CA2232813C
CA2232813C CA2232813A CA2232813A CA2232813C CA 2232813 C CA2232813 C CA 2232813C CA 2232813 A CA2232813 A CA 2232813A CA 2232813 A CA2232813 A CA 2232813A CA 2232813 C CA2232813 C CA 2232813C
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human
immunoglobulin
gene
sequence
transgene
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CA2232813A1 (fr
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Nils Lonberg
Robert M. Kay
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Genpharm International Inc
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Genpharm International Inc
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • A—HUMAN NECESSITIES
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    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
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    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
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    • C07K16/4266—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig against anti-tumor receptor Ig
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Abstract

L'invention porte sur des animaux non humains transgéniques pouvant produire des anticorps hétérologues, et sur des procédés de production d'anticorps à séquence humaine qui se lient à des antigènes humains avec une affinité importante.
CA2232813A 1995-10-10 1996-10-10 Animaux non humains transgeniques pouvant produire des anticorps heterologues Expired - Lifetime CA2232813C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/544,404 US5770429A (en) 1990-08-29 1995-10-10 Transgenic non-human animals capable of producing heterologous antibodies
US08/544,404 1995-10-10
PCT/US1996/016433 WO1997013852A1 (fr) 1995-10-10 1996-10-10 Animaux non humains transgeniques pouvant produire des anticorps heterologues

Publications (2)

Publication Number Publication Date
CA2232813A1 CA2232813A1 (fr) 1997-04-17
CA2232813C true CA2232813C (fr) 2013-12-17

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CA2232813A Expired - Lifetime CA2232813C (fr) 1995-10-10 1996-10-10 Animaux non humains transgeniques pouvant produire des anticorps heterologues

Country Status (13)

Country Link
US (1) US5770429A (fr)
EP (3) EP1813672A3 (fr)
JP (6) JP2000502324A (fr)
CN (3) CN1286975C (fr)
AT (1) ATE466936T1 (fr)
AU (1) AU729290B2 (fr)
CA (1) CA2232813C (fr)
DE (1) DE69638184D1 (fr)
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