AU5759899A - Hydroxyflavone derivatives as tau protein kinase 1 inhibitors - Google Patents
Hydroxyflavone derivatives as tau protein kinase 1 inhibitorsInfo
- Publication number
- AU5759899A AU5759899A AU57598/99A AU5759899A AU5759899A AU 5759899 A AU5759899 A AU 5759899A AU 57598/99 A AU57598/99 A AU 57598/99A AU 5759899 A AU5759899 A AU 5759899A AU 5759899 A AU5759899 A AU 5759899A
- Authority
- AU
- Australia
- Prior art keywords
- inhibitors
- protein kinase
- tau protein
- hydroxyflavone derivatives
- hydroxyflavone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP27026298 | 1998-09-24 | ||
JP10/270262 | 1998-09-24 | ||
PCT/JP1999/005223 WO2000017184A1 (en) | 1998-09-24 | 1999-09-24 | Hydroxyflavone derivatives as tau protein kinase 1 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
AU5759899A true AU5759899A (en) | 2000-04-10 |
Family
ID=17483811
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU57598/99A Abandoned AU5759899A (en) | 1998-09-24 | 1999-09-24 | Hydroxyflavone derivatives as tau protein kinase 1 inhibitors |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1115718A1 (en) |
JP (1) | JP2002526488A (en) |
KR (1) | KR20010079922A (en) |
CN (1) | CN1326450A (en) |
AU (1) | AU5759899A (en) |
CA (1) | CA2345311A1 (en) |
WO (1) | WO2000017184A1 (en) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6472436B1 (en) * | 2000-07-17 | 2002-10-29 | The Salk Institute For Biological Studies | Methods for protecting cells from amyloid toxicity and for inhibiting amyloid protein production |
EP1537102A4 (en) * | 2002-08-16 | 2010-12-08 | Astrazeneca Ab | Inhibition of phsphoinostide 3-dinase beta |
WO2006045096A2 (en) | 2004-10-20 | 2006-04-27 | Resverlogix Corp. | Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases |
EP2258357A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
EP2275096A3 (en) | 2005-08-26 | 2011-07-13 | Braincells, Inc. | Neurogenesis via modulation of the muscarinic receptors |
WO2007047978A2 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
JP2009536669A (en) | 2006-05-09 | 2009-10-15 | ブレインセルス,インコーポレイティド | Neurogenesis by angiotensin regulation |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
EP2118074B1 (en) | 2007-02-01 | 2014-01-22 | Resverlogix Corp. | Compounds for the prevention and treatment of cardiovascular diseases |
US20080227829A1 (en) * | 2007-02-14 | 2008-09-18 | Hammerstone John F | Neurogenic compounds |
KR101629356B1 (en) | 2008-06-26 | 2016-06-13 | 리스버로직스 코퍼레이션 | Methods of preparing quinazolinone derivatives |
EP2660238B1 (en) | 2009-01-08 | 2015-05-06 | Resverlogix Corporation | Compounds for the prevention and treatment of cardiovascular disease |
WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
NZ617779A (en) | 2009-03-18 | 2015-08-28 | Resverlogix Corp | Novel anti-inflammatory agents |
ES2706651T3 (en) | 2009-04-22 | 2019-03-29 | Resverlogix Corp | New anti-inflammatory agents |
CA2851996C (en) | 2011-11-01 | 2020-01-07 | Resverlogix Corp. | Pharmaceutical compositions for substituted quinazolinones |
WO2013111850A1 (en) | 2012-01-26 | 2013-08-01 | 第一三共株式会社 | Chromone derivative having osteogenesis promoting effect |
US9765039B2 (en) | 2012-11-21 | 2017-09-19 | Zenith Epigenetics Ltd. | Biaryl derivatives as bromodomain inhibitors |
US9073878B2 (en) | 2012-11-21 | 2015-07-07 | Zenith Epigenetics Corp. | Cyclic amines as bromodomain inhibitors |
US9271978B2 (en) | 2012-12-21 | 2016-03-01 | Zenith Epigenetics Corp. | Heterocyclic compounds as bromodomain inhibitors |
JP6468549B2 (en) * | 2015-01-30 | 2019-02-13 | 国立大学法人金沢大学 | Benzothiophene derivatives with anticancer activity |
JO3789B1 (en) | 2015-03-13 | 2021-01-31 | Resverlogix Corp | Compositions and therapeutic methods for the treatment of complement -associated diseases |
JP6416828B2 (en) * | 2016-06-23 | 2018-10-31 | 株式会社レーネ | Tau protein aggregation inhibitor |
CN109111400B (en) * | 2017-06-23 | 2020-10-16 | 杭州百诚医药科技股份有限公司 | Preparation and application of phenylquinolinone and flavonoid derivatives |
CN108299365B (en) * | 2018-01-31 | 2021-08-06 | 中南大学 | Flavone derivative and application thereof |
GB202104134D0 (en) * | 2021-03-24 | 2021-05-05 | Floratek Pharma Ag | Compounds and their use |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1362782A (en) * | 1970-08-26 | 1974-08-07 | Fisons Ltd | Tetrazole derivatives |
CA2116460A1 (en) * | 1993-03-02 | 1994-09-03 | Mitsubishi Chemical Corporation | Preventive or therapeutic agents for alzheimer's disease, a screening method of alzheimer's disease and tau-protein kinase i originated from human being |
CA2182932A1 (en) * | 1995-08-10 | 1997-02-11 | Koju Watanabe | Chromone derivative, process for preparing same and pharmaceutical composition |
JPH09301915A (en) * | 1996-05-08 | 1997-11-25 | Sankyo Co Ltd | Flavone and naphthalene derivative |
FR2753969B1 (en) * | 1996-09-27 | 1998-10-30 | Adir | NOVEL FLAVON DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME |
-
1999
- 1999-09-24 AU AU57598/99A patent/AU5759899A/en not_active Abandoned
- 1999-09-24 CN CN99813534A patent/CN1326450A/en active Pending
- 1999-09-24 CA CA002345311A patent/CA2345311A1/en not_active Abandoned
- 1999-09-24 WO PCT/JP1999/005223 patent/WO2000017184A1/en not_active Application Discontinuation
- 1999-09-24 JP JP2000574094A patent/JP2002526488A/en active Pending
- 1999-09-24 KR KR1020017003819A patent/KR20010079922A/en not_active Application Discontinuation
- 1999-09-24 EP EP99944814A patent/EP1115718A1/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
JP2002526488A (en) | 2002-08-20 |
KR20010079922A (en) | 2001-08-22 |
CN1326450A (en) | 2001-12-12 |
WO2000017184A1 (en) | 2000-03-30 |
CA2345311A1 (en) | 2000-03-30 |
EP1115718A1 (en) | 2001-07-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |