AU2001279284A1 - Rapid-melt semi-solid compositions, methods of making same and methods of using same - Google Patents

Rapid-melt semi-solid compositions, methods of making same and methods of using same

Info

Publication number
AU2001279284A1
AU2001279284A1 AU2001279284A AU7928401A AU2001279284A1 AU 2001279284 A1 AU2001279284 A1 AU 2001279284A1 AU 2001279284 A AU2001279284 A AU 2001279284A AU 7928401 A AU7928401 A AU 7928401A AU 2001279284 A1 AU2001279284 A1 AU 2001279284A1
Authority
AU
Australia
Prior art keywords
methods
same
rapid
solid compositions
melt semi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001279284A
Inventor
Subraman Rao Cherukuri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Capricorn Pharma Inc
Original Assignee
Capricorn Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/610,489 external-priority patent/US6375982B1/en
Application filed by Capricorn Pharma Inc filed Critical Capricorn Pharma Inc
Publication of AU2001279284A1 publication Critical patent/AU2001279284A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/075Ethers or acetals
    • A61K31/085Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • A61K31/375Ascorbic acid, i.e. vitamin C; Salts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/60Salicylic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726Glycosaminoglycans, i.e. mucopolysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
AU2001279284A 2000-07-05 2001-07-05 Rapid-melt semi-solid compositions, methods of making same and methods of using same Abandoned AU2001279284A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US09610489 2000-07-05
US09/610,489 US6375982B1 (en) 2000-07-05 2000-07-05 Rapid-melt semi-solid compositions, methods of making same and method of using same
US09858885 2001-05-17
US09/858,885 US6589556B2 (en) 2000-07-05 2001-05-17 Rapid-melt semi-solid compositions, methods of making same and methods of using same
PCT/US2001/041272 WO2002002081A1 (en) 2000-07-05 2001-07-05 Rapid-melt semi-solid compositions, methods of making same and methods of using same

Publications (1)

Publication Number Publication Date
AU2001279284A1 true AU2001279284A1 (en) 2002-01-14

Family

ID=27086265

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001279284A Abandoned AU2001279284A1 (en) 2000-07-05 2001-07-05 Rapid-melt semi-solid compositions, methods of making same and methods of using same

Country Status (3)

Country Link
US (3) US7229641B2 (en)
AU (1) AU2001279284A1 (en)
WO (1) WO2002002081A1 (en)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7364752B1 (en) 1999-11-12 2008-04-29 Abbott Laboratories Solid dispersion pharamaceutical formulations
DE60028754T2 (en) 1999-11-12 2007-05-31 Abbott Laboratories, Abbott Park SOLID DISPERSION WITH RITONAVIR, FENOFIBRATE OR GRISEOFULVIN
DE10026698A1 (en) * 2000-05-30 2001-12-06 Basf Ag Self-emulsifying active ingredient formulation and use of this formulation
WO2002002081A1 (en) * 2000-07-05 2002-01-10 Capricorn Pharma, Inc. Rapid-melt semi-solid compositions, methods of making same and methods of using same
US20100010101A1 (en) * 2000-07-05 2010-01-14 Capricorn Pharma, Inc. Rapid-Melt Compositions and Methods of Making Same
US20030235613A1 (en) * 2002-06-19 2003-12-25 Cts Chemical Industries Ltd. Popping oral administration form
US20080213363A1 (en) * 2003-01-23 2008-09-04 Singh Nikhilesh N Methods and compositions for delivering 5-HT3 antagonists across the oral mucosa
JP2006523620A (en) * 2003-02-19 2006-10-19 バイオヴェイル ラボラトリーズ インコーポレイテッド Rapid absorption selective 5-HT agent formulation
US20050042281A1 (en) * 2003-08-21 2005-02-24 Singh Nikhilesh N. Compositions for delivering therapeutic agents across the oral mucosa
US7390503B1 (en) 2003-08-22 2008-06-24 Barr Laboratories, Inc. Ondansetron orally disintegrating tablets
US8377952B2 (en) * 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
EP1750862B1 (en) 2004-06-04 2011-01-05 Teva Pharmaceutical Industries Ltd. Pharmaceutical composition containing irbesartan
US8252321B2 (en) 2004-09-13 2012-08-28 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like
EP1802258A4 (en) 2004-09-13 2015-09-23 Chrono Therapeutics Inc Biosynchronous transdermal drug delivery
US8758816B2 (en) 2004-11-24 2014-06-24 Meda Pharmaceuticals Inc. Compositions comprising azelastine and methods of use thereof
DK2486942T3 (en) 2004-11-24 2019-01-28 Meda Pharmaceuticals Inc COMPOSITIONS CONTAINING AZELASTINE AND PROCEDURES FOR USING IT
US20070020330A1 (en) 2004-11-24 2007-01-25 Medpointe Healthcare Inc. Compositions comprising azelastine and methods of use thereof
US8497258B2 (en) 2005-11-12 2013-07-30 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
US8679545B2 (en) 2005-11-12 2014-03-25 The Regents Of The University Of California Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract
US8324192B2 (en) 2005-11-12 2012-12-04 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
US9101160B2 (en) 2005-11-23 2015-08-11 The Coca-Cola Company Condiments with high-potency sweetener
US20080069889A1 (en) * 2006-03-07 2008-03-20 Cherukuri S R Compressible resilient granules and formulations prepared therefrom
US20070243248A1 (en) * 2006-04-14 2007-10-18 Cherukuri S Rao Rapidly disintegrating solid oral dosage form of liquid dispersions
US20070259040A1 (en) * 2006-05-01 2007-11-08 Cherukuri S R Novel triptan formulations and methods for making them
WO2008002529A2 (en) * 2006-06-26 2008-01-03 Capricorn Pharma, Inc. Orally disintegrating layered compositions
US8716200B2 (en) 2006-09-13 2014-05-06 Ecolab Usa Inc. Conveyor lubricants including emulsion of a lipophilic compound and an emulsifier and/or an anionic surfactant and methods employing them
WO2008039358A2 (en) * 2006-09-30 2008-04-03 Capricorn Pharma Inc. Resin-complex granulation for water-soluble drugs and associated methods
US8580855B2 (en) 2006-10-20 2013-11-12 Mcneil-Ppc, Inc. Acetaminophen / ibuprofen combinations and method for their use
US8017168B2 (en) 2006-11-02 2011-09-13 The Coca-Cola Company High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith
CN101772346B (en) 2007-04-02 2014-05-07 帕金森氏病研究院 Methods and compositions for reduction of side effects of therapeutic treatments
US10512597B2 (en) * 2007-09-06 2019-12-24 Colgate-Palmolive Company Controlled surface gelling of mucoadhesive polymers on oral mucosa
US8865692B2 (en) * 2007-11-13 2014-10-21 Meritage Pharma, Inc Compositions for the treatment of gastrointestinal inflammation
US20090123551A1 (en) * 2007-11-13 2009-05-14 Meritage Pharma, Inc. Gastrointestinal delivery systems
DK2214677T3 (en) 2007-11-13 2017-11-20 Meritage Pharma Inc Compositions for the treatment of inflammation of the gastrointestinal tract
US20100216754A1 (en) * 2007-11-13 2010-08-26 Meritage Pharma, Inc. Compositions for the treatment of inflammation of the gastrointestinal tract
US20090264392A1 (en) * 2008-04-21 2009-10-22 Meritage Pharma, Inc. Treating eosinophilic esophagitis
RU2011116655A (en) * 2008-10-06 2012-11-10 Вм. Ригли Дж. Компани (Us) METHOD FOR MAINTAINING EFFECTIVE QUANTITY OF WATER-RESOLVABLE VITAMIN IN HUMAN BLEED, ITS DELIVERY SYSTEM, ITS KIT AND CHEWING COMPOSITION
US20100190739A1 (en) * 2008-12-15 2010-07-29 Fleming And Company, Pharmaceuticals Rapidly Dissolving Vitamin Formulation and Methods of Using the Same
NZ594738A (en) * 2009-01-23 2013-11-29 Hanmi Science Co Ltd Solid pharmaceutical composition comprising amlodipine and losartan and process for producing same
US20100278913A1 (en) * 2009-04-30 2010-11-04 Sancilio & Company Chewable tablet
US20110223312A1 (en) * 2009-11-30 2011-09-15 Daniel Perlman Triglyceride-encapsulated phytosterol microparticles dispersed in beverages
ES2613738T3 (en) 2010-05-12 2017-05-25 Rempex Pharmaceuticals, Inc. Tetracycline compositions
CA2841785A1 (en) 2011-07-06 2013-01-10 The Parkinson's Institute Compositions and methods for treatment of symptoms in parkinson's disease patients
US20130071476A1 (en) * 2011-08-19 2013-03-21 Subraman Rao Cherukuri Rapid Melt Controlled Release Taste-Masked Compositions
US8460738B1 (en) 2012-05-04 2013-06-11 Brandeis University Liquid crystalline phytosterol-glycerine complex for enhanced bioavailability and water dispersal
DE102013004263A1 (en) * 2013-03-13 2014-09-18 Martin Lipsdorf Fast-dissolving oral dosage form and method of making the same
JP2018511355A (en) 2015-01-28 2018-04-26 クロノ セラピューティクス インコーポレイテッドChrono Therapeutics Inc. Drug delivery method and system
CA2977814A1 (en) 2015-03-12 2016-09-15 Chrono Therapeutics Inc. Craving input and support system
US10292977B2 (en) 2016-04-11 2019-05-21 Neurocea, LLC Compositions and methods for treatment related to fall and fall frequency in neurodegenerative diseases
US10143687B2 (en) 2016-04-11 2018-12-04 Neurocea, LLC Compositions and methods for treatment related to fall and fall frequency in neurodegenerative diseases
US11285306B2 (en) 2017-01-06 2022-03-29 Morningside Venture Investments Limited Transdermal drug delivery devices and methods
JP7042275B2 (en) 2017-01-11 2022-03-25 フェリング・ベー・フェー Fast-disintegrating pharmaceutical composition
EP3801732A4 (en) 2018-05-29 2022-04-27 Morningside Venture Investments Limited Drug delivery methods and systems
CN111991440A (en) * 2020-08-24 2020-11-27 常州工学院 Method for extracting flavonoid compounds in cinnamomum camphora by polymer aqueous two-phase extraction
WO2023011660A1 (en) * 2021-08-06 2023-02-09 Sansure Biotech Inc. Compositions for liquefying a viscous biological sample, combination products, liquefying agents, and kits thereof, and methods and application thereof

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4327076A (en) * 1980-11-17 1982-04-27 Life Savers, Inc. Compressed chewable antacid tablet and method for forming same
US4327077A (en) * 1981-05-29 1982-04-27 Life Savers, Inc. Compressed chewable antacid tablet and method for forming same
US4446135A (en) * 1982-06-07 1984-05-01 Sterling Drug Inc. Chewable antacid tablets
US4609543A (en) * 1983-11-14 1986-09-02 Nabisco Brands, Inc. Soft homogeneous antacid tablet
US4937076A (en) * 1984-08-10 1990-06-26 Combe Incorporated Chewable aspirin and buffering material tablet and method for producing same
US4684534A (en) * 1985-02-19 1987-08-04 Dynagram Corporation Of America Quick-liquifying, chewable tablet
DK8603837A (en) * 1985-08-13 1987-02-14
WO1987001936A1 (en) * 1985-09-25 1987-04-09 Gerhard Gergely Desintegration tablet and process for its manufacture
GB2195891A (en) 1986-10-06 1988-04-20 Procter & Gamble Improving palatability of pharmaceutical chewable tablets
US4786502A (en) 1986-10-06 1988-11-22 The Procter & Gamble Company Palatable solid pharmaceutical compositions
US5387431A (en) * 1991-10-25 1995-02-07 Fuisz Technologies Ltd. Saccharide-based matrix
US5204116A (en) * 1991-05-01 1993-04-20 Alza Corporation Dosage form providing immediate therapy followed by prolonged therapy
DK0587744T3 (en) * 1991-05-28 2003-10-20 Mcneil Ppc Inc Chewable composition for release of a drug
WO1993015724A1 (en) * 1992-02-18 1993-08-19 Nippon Shinyaku Co., Ltd. Fast soluble tablet
SI9200139A (en) * 1992-07-08 1994-03-31 Lek Tovarna Farmacevtskih New inclusion complex of clavulanic acid with hydrophylyc and hydropholyc beta-cyclodextrin derivates for production of them
US5419954A (en) * 1993-02-04 1995-05-30 The Alpha Corporation Composition including a catalytic metal-polymer complex and a method of manufacturing a laminate preform or a laminate which is catalytically effective for subsequent electroless metallization thereof
US5690959A (en) * 1993-05-29 1997-11-25 Smithkline Beecham Corporation Pharmaceutical thermal infusion process
EP0667640A3 (en) * 1994-01-14 1997-05-14 Brush Wellman Multilayer laminate product and process.
GB9408117D0 (en) * 1994-04-23 1994-06-15 Smithkline Beecham Corp Pharmaceutical formulations
GB9416600D0 (en) * 1994-08-17 1994-10-12 Smithkline Beecham Plc Pharmaceutical formulation
US6645988B2 (en) * 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
IL117773A (en) * 1996-04-02 2000-10-31 Pharmos Ltd Solid lipid compositions of coenzyme Q10 for enhanced oral bioavailability
US6024363A (en) * 1996-09-30 2000-02-15 Johnson, Jr.; Theodore C. Gasket for use with an air brake hose coupling member
US5753255A (en) * 1997-02-11 1998-05-19 Chavkin; Leonard Chewable molded tablet containing medicinally active substances
US6024981A (en) 1997-04-16 2000-02-15 Cima Labs Inc. Rapidly dissolving robust dosage form
US5840334A (en) * 1997-08-20 1998-11-24 Fuisz Technologies Ltd. Self-binding shearform compositions
US5912012A (en) * 1997-09-06 1999-06-15 Carlin; Edward J. Effervescent systems with simplified packaging requirements
FR2781152B1 (en) * 1998-07-20 2001-07-06 Permatec Tech Ag USE OF ACRYLIC-TYPE POLYMER AS A DISAGGREGING AGENT
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US6565882B2 (en) * 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
US6419954B1 (en) * 2000-05-19 2002-07-16 Yamanouchi Pharmaceutical Co., Ltd. Tablets and methods for modified release of hydrophilic and other active agents
WO2002002081A1 (en) * 2000-07-05 2002-01-10 Capricorn Pharma, Inc. Rapid-melt semi-solid compositions, methods of making same and methods of using same
US6375982B1 (en) * 2000-07-05 2002-04-23 Capricorn Pharma, Inc. Rapid-melt semi-solid compositions, methods of making same and method of using same
JP4116436B2 (en) * 2000-12-14 2008-07-09 エフ.ホフマン−ラ ロシュ アーゲー Self-emulsifying lipid matrix (SELM)
US6735982B2 (en) * 2001-07-12 2004-05-18 Intel Corporation Processing relatively thin glass sheets
DE60124895D1 (en) * 2001-07-26 2007-01-11 Ethypharm Sa Coated allylamines or benzylamines containing granules, process for the preparation and in the oral cavity dispersible tablets containing the coated granules
FR2855756B1 (en) * 2003-06-06 2005-08-26 Ethypharm Sa MULTILAYER ORODISPERSIBLE TABLET
US7282217B1 (en) * 2003-08-29 2007-10-16 Kv Pharmaceutical Company Rapidly disintegrable tablets
TWI342222B (en) * 2004-03-08 2011-05-21 Medical & Pharm Ind Tech & Dev Pharmaceutical composition of rapidly dissolving tablet and method of fabricating the same
WO2008002529A2 (en) * 2006-06-26 2008-01-03 Capricorn Pharma, Inc. Orally disintegrating layered compositions

Also Published As

Publication number Publication date
US20090304824A1 (en) 2009-12-10
US20080020065A1 (en) 2008-01-24
US7229641B2 (en) 2007-06-12
US20020187188A1 (en) 2002-12-12
WO2002002081A1 (en) 2002-01-10

Similar Documents

Publication Publication Date Title
AU2001276048A1 (en) Rapid-melt semi-solid compositions, methods of making same and methods of using same
AU2001279284A1 (en) Rapid-melt semi-solid compositions, methods of making same and methods of using same
AU2778801A (en) Antisense compositions and methods
AU4099199A (en) Encapsulated breakers, compositions and methods of use
AU2002357119A1 (en) Mitocidal compositions and methods
AU2001294814A1 (en) Pumpcn compositions and uses thereof
AU2002217226A1 (en) Methanesulphonamido-benzofuran, preparation method and use thereof as synthesis intermediate
AU2001241474A1 (en) Biosensor compositions and methods of use
AU2001280604A1 (en) Compositions comprising icariside i and anhydroicaritin and methods for making the same
AU2001262608A1 (en) Semi-solid one- or two-part compositions
AU2001266926A1 (en) Hemostatic compositions, devices and methods
AU2001280606A1 (en) Gel form automatic dishwashing compositions, methods of preparation and use thereof
AU2001271031A1 (en) Cosmetic compositions for reducing and method of using the same
AU2001275155A1 (en) Superoxide-generating diazeniumdiolates, compositions comprising same, and methods for using same
AU2002357748A1 (en) Osteopontin-related compositions and methods
AU2002215333A1 (en) Compositions for release of radiosensitizers, and methods of making and using the same
AU2001233932A1 (en) Method and composition
AU2002345878A1 (en) Ilt3 and ilt4-related compositions and methods
AU2001269730A1 (en) Low carbohydrate compositions, kits thereof, and methods of use
AU2002239739A1 (en) Compositions, methods and kits relating to remodelin
AU3883800A (en) Hob-bp2h compositions, methods and uses thereof
AU2001270310A1 (en) Compositions for sustained release of antineoplastic taxanes, and methods of making and using the same
AU5179800A (en) Mycolactone and related compounds, compositions and methods of use
AU2001297556A1 (en) 38650, 28472, 5495, 65507, 81588 and 14354 methods and compositions of human proteins and uses thereof
AU2002239775A1 (en) Chemical-library composition and method