AU2001275155A1 - Superoxide-generating diazeniumdiolates, compositions comprising same, and methods for using same - Google Patents

Superoxide-generating diazeniumdiolates, compositions comprising same, and methods for using same

Info

Publication number
AU2001275155A1
AU2001275155A1 AU2001275155A AU7515501A AU2001275155A1 AU 2001275155 A1 AU2001275155 A1 AU 2001275155A1 AU 2001275155 A AU2001275155 A AU 2001275155A AU 7515501 A AU7515501 A AU 7515501A AU 2001275155 A1 AU2001275155 A1 AU 2001275155A1
Authority
AU
Australia
Prior art keywords
same
diazeniumdiolates
superoxide
compositions
generating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001275155A
Inventor
Challice Bonifant
Gregory Buzard
Michael Citro
Paul Donovan
Anthony Fitzhugh
Xinhua Ji
Larry Keefer
Joseph Saavedra
Paul Shami
Shivendra Singh
Aloka Srinivasan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Original Assignee
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services filed Critical US Department of Health and Human Services
Publication of AU2001275155A1 publication Critical patent/AU2001275155A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C07C291/08—Azoxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/50—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0206—Polyalkylene(poly)amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/24—Anthracenes; Hydrogenated anthracenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2001275155A 2000-06-02 2001-07-01 Superoxide-generating diazeniumdiolates, compositions comprising same, and methods for using same Abandoned AU2001275155A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20906700P 2000-06-02 2000-06-02
US60209067 2000-06-02
PCT/US2001/017868 WO2001092215A2 (en) 2000-06-02 2001-06-01 Superoxide-generating diazeniumdiolates, compositions comprising same, and methods for using same

Publications (1)

Publication Number Publication Date
AU2001275155A1 true AU2001275155A1 (en) 2001-12-11

Family

ID=22777186

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001275155A Abandoned AU2001275155A1 (en) 2000-06-02 2001-07-01 Superoxide-generating diazeniumdiolates, compositions comprising same, and methods for using same

Country Status (2)

Country Link
AU (1) AU2001275155A1 (en)
WO (1) WO2001092215A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002228652A1 (en) * 2000-11-27 2002-06-03 The University Of Akron Treatment of disorders using polyethylenimine diazeniumdiolate
AU2003230715A1 (en) 2002-03-21 2003-10-08 The University Of Utah Research Foundation In vivo use of glutathionone s-transferase activated nitric oxide donors
EP1507526A2 (en) 2002-05-07 2005-02-23 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Polydiazeniumdiolated cyclic polyamines with polyphasic nitric oxide release and related compounds, compositions comprising same and methods of using same
WO2005081752A2 (en) * 2004-02-09 2005-09-09 Amulet Pharmaceuticals, Inc. Nitric oxide-releasing polymers
US20080305082A1 (en) * 2004-09-14 2008-12-11 Curd John G 1,4-Bis-N-Oxide-5,8- Dihydroxyanthracenedione Compounds and the Use Thereof
WO2006130775A2 (en) 2005-06-01 2006-12-07 Edison Pharmaceuticals, Inc. Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomakers
LT1933821T (en) 2005-09-15 2020-11-10 Ptc Therapeutics, Inc. Tail variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
EP1986636B1 (en) 2006-02-22 2013-04-24 Edison Pharmaceuticals, Inc. Phenol and 1,4-benzoquinone derivatives for use in the treatment of mitochondrial diseases
DE102007035323A1 (en) 2007-07-25 2009-01-29 Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e.V. -Hans-Knöll-Institut- New diazen-1-ium-1,2-diolate substituted ketoconazole derivatives are ergosterol biosynthesis inhibitors useful as an active agent against microbial pathogenic germs, e.g. fungus, and an antiinflammatory active agent
KR20110005798A (en) 2008-03-07 2011-01-19 유타대학연구재단 Activated nitric oxide donors and methods of making and using thereof
CA2736250C (en) 2008-09-10 2016-12-20 Edison Pharmaceuticals, Inc. Treatment of pervasive developmental disorders with redox-active therapeutics
KR101351130B1 (en) * 2012-11-05 2014-01-15 포항공과대학교 산학협력단 Method for preparing coating film containing nitrogen monoxide using catecholamines in the surface of materials
CN113024369A (en) 2015-12-17 2021-06-25 Ptc医疗公司 Compounds for the treatment of oxidative stress disorders
CN109053618B (en) * 2018-02-22 2022-05-13 青岛科技大学 Preparation method of oxazole derivative
CN112939886B (en) * 2021-02-04 2022-05-31 山西大学 Near-infrared fluorescent probe capable of detecting content of GSTs (glutathione S-terminal transferase) as well as synthetic method and application thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5405919A (en) * 1992-08-24 1995-04-11 The United States Of America As Represented By The Secretary Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders
ATE283267T1 (en) * 1996-09-27 2004-12-15 Us Gov Health & Human Serv O2-ARYLATE OR O2 GLYCOSYIATE 1-SUBSTITUTED DIAZENE-1-IUM-1,2-DIOLATE AND O2-SUBSTITUTED 1(2-CARBOXYLATE) PYROLIDINE-1-YL DIAZENE-1-IUM-1,2-DIOLATE

Also Published As

Publication number Publication date
WO2001092215A2 (en) 2001-12-06
WO2001092215A3 (en) 2002-06-27

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