AU2001269095A1 - Regulation of human caspase-1-like protease - Google Patents

Regulation of human caspase-1-like protease

Info

Publication number
AU2001269095A1
AU2001269095A1 AU2001269095A AU6909501A AU2001269095A1 AU 2001269095 A1 AU2001269095 A1 AU 2001269095A1 AU 2001269095 A AU2001269095 A AU 2001269095A AU 6909501 A AU6909501 A AU 6909501A AU 2001269095 A1 AU2001269095 A1 AU 2001269095A1
Authority
AU
Australia
Prior art keywords
protease
regulation
human caspase
caspase
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001269095A
Inventor
Shyam Ramakrishnan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of AU2001269095A1 publication Critical patent/AU2001269095A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/22—Cysteine endopeptidases (3.4.22)
    • C12Y304/22036—Caspase-1 (3.4.22.36), i.e. interleukin-1-beta-convertase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2001269095A 2000-06-26 2001-06-26 Regulation of human caspase-1-like protease Abandoned AU2001269095A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21400900P 2000-06-26 2000-06-26
US60/214,009 2000-06-26
PCT/EP2001/007287 WO2002000853A2 (en) 2000-06-26 2001-06-26 Regulation of human caspase-1-like protease

Publications (1)

Publication Number Publication Date
AU2001269095A1 true AU2001269095A1 (en) 2002-01-08

Family

ID=22797417

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001269095A Abandoned AU2001269095A1 (en) 2000-06-26 2001-06-26 Regulation of human caspase-1-like protease

Country Status (4)

Country Link
US (2) US20040132023A1 (en)
EP (1) EP1297154A2 (en)
AU (1) AU2001269095A1 (en)
WO (1) WO2002000853A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1746167A1 (en) * 2005-07-20 2007-01-24 Apoxis SA Method for the identification of compounds susceptible to inhibit inflammation
US20120315244A1 (en) 2009-09-30 2012-12-13 President And Fellows Of Harvard College Methods for Modulation of Autophagy Through the Modulation of Autophagy-Inhibiting Gene Products
DE102011118024A1 (en) * 2011-08-01 2013-02-07 Technische Universität Dresden New procaspase 1 expression inhibitor, useful for preventing and/or treating inflammatory diseases, which are autoinflammatory diseases

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962301A (en) 1992-06-12 1999-10-05 Massachusetts Institute Of Technology Relatedness of human interleukin-1β convertase gene to a C. elegans cell death gene, inhibitory portions of these genes and uses therefor
AU5102993A (en) 1992-09-18 1994-04-12 Merck & Co., Inc. Dna encoding murine precursor interleukin 1beta converting enzyme
US5654146A (en) * 1995-05-31 1997-08-05 Incyte Pharmaceuticals, Inc. Human ice homolog
US5869315A (en) * 1995-12-18 1999-02-09 Basf Aktiengesellschaft Modified interleukin-1β converting enzyme with increased stability
US5858778A (en) * 1996-12-27 1999-01-12 Thomas Jefferson University SF caspase-1 and compositions for making and methods of using the same
CA2328457A1 (en) * 1998-06-20 1999-12-29 Washington University Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy
JP2004515217A (en) * 2000-06-16 2004-05-27 インサイト・ゲノミックス・インコーポレイテッド Protease

Also Published As

Publication number Publication date
EP1297154A2 (en) 2003-04-02
WO2002000853A3 (en) 2002-08-08
US20040132023A1 (en) 2004-07-08
WO2002000853A2 (en) 2002-01-03
US7192732B2 (en) 2007-03-20
US20060141552A1 (en) 2006-06-29

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