ATE529402T1 - 3',6-substituierte indirubine und ihre biologischen anwendungen - Google Patents
3',6-substituierte indirubine und ihre biologischen anwendungenInfo
- Publication number
- ATE529402T1 ATE529402T1 AT08161646T AT08161646T ATE529402T1 AT E529402 T1 ATE529402 T1 AT E529402T1 AT 08161646 T AT08161646 T AT 08161646T AT 08161646 T AT08161646 T AT 08161646T AT E529402 T1 ATE529402 T1 AT E529402T1
- Authority
- AT
- Austria
- Prior art keywords
- biological applications
- substituted
- halogen
- alkyl
- indirubins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08161646A EP2149553B1 (de) | 2008-08-01 | 2008-08-01 | 3',6-substituierte Indirubine und ihre biologischen Anwendungen |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE529402T1 true ATE529402T1 (de) | 2011-11-15 |
Family
ID=40225521
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT08161646T ATE529402T1 (de) | 2008-08-01 | 2008-08-01 | 3',6-substituierte indirubine und ihre biologischen anwendungen |
AT09802595T ATE547401T1 (de) | 2008-08-01 | 2009-07-21 | 3',6-substituierte indirubine und ihre biologische anwendung |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT09802595T ATE547401T1 (de) | 2008-08-01 | 2009-07-21 | 3',6-substituierte indirubine und ihre biologische anwendung |
Country Status (6)
Country | Link |
---|---|
US (1) | US8829203B2 (de) |
EP (2) | EP2149553B1 (de) |
JP (1) | JP5577336B2 (de) |
AT (2) | ATE529402T1 (de) |
CA (1) | CA2732232C (de) |
WO (1) | WO2010013168A1 (de) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8552053B2 (en) * | 2005-12-23 | 2013-10-08 | Centre National De La Recherche Scientifique | 7-substituted indirubin-3′oximes and their applications |
ATE529402T1 (de) | 2008-08-01 | 2011-11-15 | Centre Nat Rech Scient | 3',6-substituierte indirubine und ihre biologischen anwendungen |
EP2451836A1 (de) | 2009-07-08 | 2012-05-16 | INSERM - Institut National de la Santé et de la Recherche Médicale | Verfahren zur induzierung von erweiterter selbsterneuerung von funktional differenzierten körperzellen |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
WO2013011841A1 (ja) * | 2011-07-15 | 2013-01-24 | 学校法人日本大学 | 悪性腫瘍に対する高選択的細胞毒性を有するインディルビン誘導体 |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP2760862B1 (de) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridin-4-carbonsäureamidderivate als kinaseinhibitoren |
US10435367B2 (en) * | 2013-03-14 | 2019-10-08 | City Of Hope | Indirubin derivatives, and uses thereof |
US9512076B2 (en) | 2012-02-03 | 2016-12-06 | City Of Hope | Indirubin derivatives and uses thereof in treating chronic myelogenous leukemia |
US20150087687A1 (en) | 2012-03-23 | 2015-03-26 | Dennis Brown | Compositions and methods to improve the therapeutic benefit of indirubin and analogs thereof, including meisoindigo |
AU2014236370C1 (en) | 2013-03-14 | 2019-01-17 | City Of Hope | 5-bromo-indirubins |
US20150259288A1 (en) | 2014-03-14 | 2015-09-17 | City Of Hope | 5-bromo-indirubins |
JP7005779B2 (ja) * | 2017-10-31 | 2022-02-10 | ペレメッド カンパニー リミテッド | 急性骨髄性白血病又は転移性乳癌の予防又は治療用薬剤学的組成物 |
EP4010337A4 (de) * | 2019-11-04 | 2023-08-23 | CK Regeon Inc. | Zusammensetzungen und verfahren zur unterdrückung und/oder behandlung von neurodegenerativen erkrankungen und/oder eines klinischen zustands davon |
CN113072540B (zh) * | 2021-03-29 | 2023-07-14 | 贵州医科大学 | 一种靛玉红衍生的降解剂及其制备与应用 |
WO2022229986A1 (en) * | 2021-04-29 | 2022-11-03 | Jawaharlal Nehru Centre For Advanced Scientific Research | Indirubin compounds and methods thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUP0200724A3 (en) | 1999-04-12 | 2002-10-28 | Eisenbrand Gerhard | Indigoid bisindole derivatives and pharmaceurical compositions containing them |
AU2004285522A1 (en) * | 2003-10-28 | 2005-05-12 | Centre National De La Recherche Scientifique | Indirubin-type compounds, compositions, and methods for their use |
US8552053B2 (en) | 2005-12-23 | 2013-10-08 | Centre National De La Recherche Scientifique | 7-substituted indirubin-3′oximes and their applications |
ATE529402T1 (de) | 2008-08-01 | 2011-11-15 | Centre Nat Rech Scient | 3',6-substituierte indirubine und ihre biologischen anwendungen |
-
2008
- 2008-08-01 AT AT08161646T patent/ATE529402T1/de not_active IP Right Cessation
- 2008-08-01 EP EP08161646A patent/EP2149553B1/de not_active Not-in-force
-
2009
- 2009-07-21 JP JP2011520627A patent/JP5577336B2/ja not_active Expired - Fee Related
- 2009-07-21 US US12/737,640 patent/US8829203B2/en not_active Expired - Fee Related
- 2009-07-21 AT AT09802595T patent/ATE547401T1/de active
- 2009-07-21 EP EP09802595A patent/EP2328866B1/de not_active Not-in-force
- 2009-07-21 WO PCT/IB2009/053153 patent/WO2010013168A1/en active Application Filing
- 2009-07-21 CA CA2732232A patent/CA2732232C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP2149553A1 (de) | 2010-02-03 |
EP2328866B1 (de) | 2012-02-29 |
EP2328866A1 (de) | 2011-06-08 |
WO2010013168A1 (en) | 2010-02-04 |
JP5577336B2 (ja) | 2014-08-20 |
EP2149553B1 (de) | 2011-10-19 |
US8829203B2 (en) | 2014-09-09 |
JP2011529873A (ja) | 2011-12-15 |
CA2732232A1 (en) | 2010-02-04 |
ATE547401T1 (de) | 2012-03-15 |
US20110136808A1 (en) | 2011-06-09 |
CA2732232C (en) | 2017-11-07 |
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Legal Events
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |