ATE491686T1 - Amlodipin-gentisat und verfahren zu dessen herstellung - Google Patents

Amlodipin-gentisat und verfahren zu dessen herstellung

Info

Publication number
ATE491686T1
ATE491686T1 AT04808440T AT04808440T ATE491686T1 AT E491686 T1 ATE491686 T1 AT E491686T1 AT 04808440 T AT04808440 T AT 04808440T AT 04808440 T AT04808440 T AT 04808440T AT E491686 T1 ATE491686 T1 AT E491686T1
Authority
AT
Austria
Prior art keywords
amlodipine
gentisat
production
relates
present
Prior art date
Application number
AT04808440T
Other languages
English (en)
Inventor
Jae-Sun Kim
Jin Young Choi
Je Ho Ryu
Nam Kyu Lee
Jeong-Soo Jang
Woo Jae Jang
Key An Um
Do Kum
Original Assignee
Sk Chemicals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sk Chemicals Co Ltd filed Critical Sk Chemicals Co Ltd
Application granted granted Critical
Publication of ATE491686T1 publication Critical patent/ATE491686T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
AT04808440T 2003-12-16 2004-12-15 Amlodipin-gentisat und verfahren zu dessen herstellung ATE491686T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20030092001 2003-12-16
PCT/KR2004/003309 WO2005058825A1 (en) 2003-12-16 2004-12-15 Amlodipine gentisate and a method of its preparation

Publications (1)

Publication Number Publication Date
ATE491686T1 true ATE491686T1 (de) 2011-01-15

Family

ID=36660050

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04808440T ATE491686T1 (de) 2003-12-16 2004-12-15 Amlodipin-gentisat und verfahren zu dessen herstellung

Country Status (14)

Country Link
US (1) US7442714B2 (de)
EP (1) EP1694645B1 (de)
JP (1) JP4740875B2 (de)
KR (1) KR100841409B1 (de)
CN (1) CN100591669C (de)
AT (1) ATE491686T1 (de)
AU (1) AU2004299412B2 (de)
BR (1) BRPI0417179A (de)
CA (1) CA2549832C (de)
DE (1) DE602004030616D1 (de)
ES (1) ES2357433T3 (de)
MX (1) MXPA06006922A (de)
RU (1) RU2330843C2 (de)
WO (1) WO2005058825A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101235116B1 (ko) * 2005-10-17 2013-02-20 에스케이케미칼주식회사 광학활성 암로디핀 겐티세이트 염의 제조방법
JP2008013489A (ja) * 2006-07-06 2008-01-24 Ohara Yakuhin Kogyo Kk ベシル酸アムロジピン含有錠剤
KR100913791B1 (ko) * 2006-07-21 2009-08-26 한미약품 주식회사 (ｓ)-(-)-암로디핀 캠실레이트 또는 이의 수화물 및 이를함유하는 약학적 조성물
KR100830003B1 (ko) 2006-10-31 2008-05-15 씨제이제일제당 (주) 결정성 ｓ-(-)-암로디핀 아디핀산 염 무수물 및 이의 제조방법
CA3077506A1 (en) * 2017-10-09 2019-04-18 Teva Pharmaceutical Industries Ltd. New salt and solid state forms of escitalopram
KR102178355B1 (ko) * 2018-10-19 2020-11-11 전남대학교산학협력단 심장 질환 치료용 조성물
CN110372575A (zh) * 2019-07-10 2019-10-25 复旦大学 一种二氢吡啶钙拮抗剂共晶体及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK161312C (da) * 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
GB8608335D0 (en) * 1986-04-04 1986-05-08 Pfizer Ltd Pharmaceutically acceptable salts
KR950007228B1 (ko) 1987-08-05 1995-07-07 화이자 인코포레이티드 암로디핀의 베실레이트염
CN1278791A (zh) * 1997-10-10 2001-01-03 阿温蒂斯药物制品公司 制造氮杂环烷基烷酰基假四肽的方法
US20020045613A1 (en) * 2000-04-27 2002-04-18 Heinz Pauls 1-aroyl-piperidinyl benzamidines
KR100452491B1 (ko) * 2001-03-29 2004-10-12 한미약품 주식회사 신규한 결정형 암로디핀 캠실레이트 염 및 그의 제조방법
US20070135488A1 (en) * 2002-04-13 2007-06-14 Chung You S Amlodipine nicotinate and process for the preparation thereof
KR100517383B1 (ko) * 2003-05-23 2005-09-26 동아제약주식회사 신규한 암로디핀 젠티세이트 염, 그의 제조방법 및 그의 약제학적 조성물

Also Published As

Publication number Publication date
JP2007513997A (ja) 2007-05-31
EP1694645B1 (de) 2010-12-15
US7442714B2 (en) 2008-10-28
RU2330843C2 (ru) 2008-08-10
US20070135495A1 (en) 2007-06-14
DE602004030616D1 (de) 2011-01-27
CN100591669C (zh) 2010-02-24
KR100841409B1 (ko) 2008-06-25
WO2005058825A1 (en) 2005-06-30
JP4740875B2 (ja) 2011-08-03
RU2006122472A (ru) 2008-01-27
CA2549832A1 (en) 2005-06-30
CN1956956A (zh) 2007-05-02
CA2549832C (en) 2010-10-05
EP1694645A1 (de) 2006-08-30
AU2004299412A1 (en) 2005-06-30
MXPA06006922A (es) 2006-08-23
BRPI0417179A (pt) 2007-03-06
EP1694645A4 (de) 2009-03-04
KR20050061317A (ko) 2005-06-22
AU2004299412B2 (en) 2011-08-18
ES2357433T3 (es) 2011-04-26

Similar Documents

Publication Publication Date Title
HUP0102851A2 (hu) Parazitaellenes artemizinin-származékok (endoperoxidok), eljárás előállításukra és a vegyületeket tartalmazó gyógyászati készítmények
NO20050134L (no) Difenylazetidioner substituert med syregrupper, fremgangsmate for fremstilling av disse, medikamenter inneholdende disse forbindelser og deres anvendelse
YU70901A (sh) Derivati 1,4-benzotiazepin-1,1 dioksida zamenjeni radikalima šećera, postupak za njihovu proizvodnju, lekovi koji sadrže ova jedinjenja i njihova primena
TN2010000295A1 (fr) Derives de carboxamides azabicycliques, leur preparation et leur application en therapeutique
MY141229A (en) Piperidine-benzenesulfonamide derivatives
CY1107422T1 (el) Φουραζανοβενζιμιδαζoλες
HK1066545A1 (en) Novel amlodipine camsylate and method for preparing thereof
ATE441627T1 (de) Verfahren zur herstellung von valsartan
EP2316830A3 (de) N-sulfonylierte aminosäurederivate und ihre verwendung als matriptase- inhibitoren
ATE394379T1 (de) 4-alkoxy-cyclohexan-1-amino-carbonsäureester und verfahren zu ihrer herstellung
ATE491686T1 (de) Amlodipin-gentisat und verfahren zu dessen herstellung
NO20055754L (no) Kolkisosidanaloger
NO20054418L (no) Substituert benzoylureidopyridylpiperidin- og -pyrrolidinkarboksylsyrederivater, deres fremstilling og anvendelse
TNSN06233A1 (en) 7-phenylamino-4-quinolone-3-carboxylic acid derivatives, methods for production and use thereof as medicaments
DE602004025935D1 (de) Histondeacetylaseinhibitor und verfahren zu dessen herstellung
ATE283838T1 (de) Wirksame derivate der valproinsäure zur behandlung von neurologischen und psychotischen störungen, und ein verfahren zu ihrer herstellung
ATE317380T1 (de) Bernsteinsäurederivate
SE0201936D0 (sv) Therapeutic agents
DE69908771D1 (de) Tilidin-mesylat, verfahren zu dessen herstellung und pharmazeutische zusammensetzungen
TH93343B (th) สารประกอบเคมี
TH77764B (th) อนุพันธ์ของ 1-(4-เบนซิล-ไพเพอราซิน-1-อิล)-3-เฟนิล-โพรพิโนน
TH84257A (th) เกลือชนิดแข็งของสารประกอบเบนชะเชพินและการใช้สารเหล่านั้นในการเตรียมสารประกอบทางเภสัชกรรม
TH84257B (th) "เกลือชนิดแข็งของสารประกอบเบนชะเชพินและการใช้สารเหล่านั้นในการเตรียมสารประกอบทางเภสัชกรรม"
TH77764A (th) อนุพันธ์ของ 1-(4-เบนซิล-ไพเพอราซิน-1-อิล)-3-เฟนิล-โพรพิโนน

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties