ATE247097T1 - Analgetische und immunomodulierende cannabinoiden - Google Patents

Analgetische und immunomodulierende cannabinoiden

Info

Publication number
ATE247097T1
ATE247097T1 AT99921637T AT99921637T ATE247097T1 AT E247097 T1 ATE247097 T1 AT E247097T1 AT 99921637 T AT99921637 T AT 99921637T AT 99921637 T AT99921637 T AT 99921637T AT E247097 T1 ATE247097 T1 AT E247097T1
Authority
AT
Austria
Prior art keywords
substituted
sub
ring system
line
formulae
Prior art date
Application number
AT99921637T
Other languages
English (en)
Inventor
Alexandros Makriyannis
Dai Lu
Atmaram Khanolkar
Zhaoxing Meng
Original Assignee
Univ Connecticut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Connecticut filed Critical Univ Connecticut
Application granted granted Critical
Publication of ATE247097T1 publication Critical patent/ATE247097T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT99921637T 1998-05-04 1999-05-04 Analgetische und immunomodulierende cannabinoiden ATE247097T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8400898P 1998-05-04 1998-05-04
PCT/US1999/009701 WO1999057106A1 (en) 1998-05-04 1999-05-04 Novel analgesic and immunomodulatory cannabinoids

Publications (1)

Publication Number Publication Date
ATE247097T1 true ATE247097T1 (de) 2003-08-15

Family

ID=22182164

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99921637T ATE247097T1 (de) 1998-05-04 1999-05-04 Analgetische und immunomodulierende cannabinoiden

Country Status (6)

Country Link
US (3) US20010009965A1 (de)
EP (1) EP1075470B1 (de)
AT (1) ATE247097T1 (de)
CA (1) CA2340445A1 (de)
DE (1) DE69910373T2 (de)
WO (1) WO1999057106A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2340444A1 (en) * 1998-05-04 1999-11-11 The University Of Connecticut Cannabinoids selective for the cb2 receptor
ATE247097T1 (de) 1998-05-04 2003-08-15 Univ Connecticut Analgetische und immunomodulierende cannabinoiden
US7589220B2 (en) * 1998-06-09 2009-09-15 University Of Connecticut Inhibitors of the anandamide transporter
US7897598B2 (en) 1998-06-09 2011-03-01 Alexandros Makriyannis Inhibitors of the anandamide transporter
US7161016B1 (en) 1998-11-24 2007-01-09 University Of Connecticut Cannabimimetic lipid amides as useful medications
US7276613B1 (en) 1998-11-24 2007-10-02 University Of Connecticut Retro-anandamides, high affinity and stability cannabinoid receptor ligands
US8084467B2 (en) * 1999-10-18 2011-12-27 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
AU778159B2 (en) 1999-10-18 2004-11-18 University Of Connecticut, The Peripheral cannabinoid receptor (CB2) selective ligands
US6943266B1 (en) 1999-10-18 2005-09-13 University Of Connecticut Bicyclic cannabinoid agonists for the cannabinoid receptor
US7119108B1 (en) * 1999-10-18 2006-10-10 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
US7741365B2 (en) * 1999-10-18 2010-06-22 University Of Connecticut Peripheral cannabinoid receptor (CB2) selective ligands
US6900236B1 (en) * 1999-10-18 2005-05-31 University Of Connecticut Cannabimimetic indole derivatives
US7393842B2 (en) * 2001-08-31 2008-07-01 University Of Connecticut Pyrazole analogs acting on cannabinoid receptors
EP1361876A4 (de) 2001-01-26 2004-03-31 Univ Connecticut Neue cannabimimetische liganden
CA2436133A1 (en) 2001-01-29 2002-08-08 University Of Connecticut Receptor selective cannabimimetic aminoalkylindoles
WO2003005960A2 (en) * 2001-07-13 2003-01-23 University Of Connecticut Novel bicyclic and tricyclic cannabinoids
EP1448557A4 (de) * 2001-10-26 2005-02-02 Univ Connecticut Heteroindane: eine neue klasse hochwirksamer cannabimimetischer liganden
TW200407110A (en) * 2001-11-23 2004-05-16 Astrazeneca Ab New use for the treatment of gastroesophageal reflux disease
WO2003075917A1 (en) 2002-03-08 2003-09-18 Signal Pharmaceuticals, Inc. Combination therapy for treating, preventing or managing proliferative disorders and cancers
CA2496097A1 (en) 2002-08-23 2004-03-04 University Of Connecticut Keto cannabinoids with therapeutic indications
JP2005536554A (ja) * 2002-08-23 2005-12-02 ユニバーシティ オブ コネチカット 新規なビフェニル及びビフェニル様カンナビノイド
CA2526103A1 (en) * 2003-05-20 2004-12-29 Bob M. Ii Moore Cannabinoid derivatives, methods of making, and use thereof
BRPI0417626A (pt) * 2003-12-17 2007-03-27 Akzo Nobel Nv derivado de 1-[(indol-3-il) carbonil] piperazina tricìclica, composição farmacêutica, uso de um derivado de 1-[(indol-3-il) carbonil] piperazina tricìclica
JP4705587B2 (ja) * 2003-12-17 2011-06-22 ナームローゼ・フエンノートチヤツプ・オルガノン カンナビノイドｃｂ１受容体アゴニストとしての三環式１−［（３−インドール−３−イル）カルボニル］ピペラジン誘導体
CA2571679A1 (en) * 2004-06-22 2005-12-29 Pharmos Limited Use of cb2 receptors agonists for the treatment of huntington's disease
US20060206139A1 (en) * 2005-01-19 2006-09-14 Tekulve Kurt J Vascular occlusion device
TWI366460B (en) 2005-06-16 2012-06-21 Euro Celtique Sa Cannabinoid active pharmaceutical ingredient for improved dosage forms
KR100892596B1 (ko) * 2007-02-12 2009-04-09 바이오스펙트럼 주식회사 바이페닐 다이올 유도체 및 이를 유효성분으로 포함하는조성물
KR101048594B1 (ko) 2009-05-04 2011-07-12 영남대학교 산학협력단 혈관신생 및 암의 성장을 억제하는 카나비노이드 유도체를 함유하는 약학조성물

Family Cites Families (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US119972A (en) * 1871-10-17 Improvement in windmills
US77649A (en) * 1868-05-05 Charles parker and edmund parker
US77851A (en) * 1868-05-12 Hie am tayloe
US149082A (en) * 1874-03-31 Improvement in sack-scales
US120094A (en) * 1871-10-17 Improvement in apparatus for compressing air
US87590A (en) * 1869-03-09 Improved last
US3041343A (en) 1959-10-14 1962-06-26 Sandoz Ltd 4-(thienyl-2'')-and 4-(pyridyl-3'')-5-aminopyrazoles
US3577458A (en) 1966-11-14 1971-05-04 Allied Chem Process for the preparation of isocyanates
US3465024A (en) 1966-11-14 1969-09-02 Allied Chem Process for the preparation of isocyanates
US3573327A (en) 1970-03-23 1971-03-30 Searle & Co 3-(lower alkoxy)-7,8,9,10-tetrahydro-6h-dibenzo-(b,d) pyran-6,9-diones and derivatives thereof
US3656906A (en) 1970-04-13 1972-04-18 Little Inc A Method for detecting and quantitating the presence of cannabinoids and analogs thereof in biological materials and resulting products
US3838131A (en) 1972-04-03 1974-09-24 Pfizer Di(dialkylamino alkoxy)phenanthridines as antiviral agents
US3915996A (en) * 1972-10-16 1975-10-28 Abbott Lab Process for making benzopyrans
GB1436771A (en) * 1973-02-16 1976-05-26 Labaz Indole derivatives and process for preparing the same
DE2335136A1 (de) 1973-07-06 1975-01-16 Schering Ag 7-hydroxy-delta hoch 8-tetrahydrocannabinole
US3886184A (en) * 1973-08-03 1975-05-27 Lilly Co Eli Aminodibenzo(b,d)pyrans
US3944673A (en) 1973-11-05 1976-03-16 Eli Lilly And Company Hexahydro-dibenzo[b,d]pyran-9-ones as analgesic drugs
US3953603A (en) 1973-11-05 1976-04-27 Eli Lilly And Company Hexahydro-dibenzo[b,d,]pyran-9-ones as psychotropic, particularly anti-depressant drugs
US4278603A (en) 1973-11-05 1981-07-14 Eli Lilly And Company Novel polymorphic crystalline form of dibenzopyranone
US3928598A (en) 1973-11-05 1975-12-23 Lilly Co Eli Hexahydro-dibenzo{8 b,d{9 pyran-9-ones as an anti-anxiety drug
IL48824A (en) 1976-01-12 1980-05-30 Yissum Res Dev Co Pharmaceutical compositions containing (3s,js) tetrahydrocanabinol derivatives and some novel compounds of this type
US4036857A (en) * 1976-02-02 1977-07-19 Sharps Associates Benzopyrans having an unsaturated side chain
US4088777A (en) 1976-02-17 1978-05-09 Eli Lilly And Company Hexahydro-dibenzo[b,d]pyran-9-ones as anticonvulsant drugs
US4087545A (en) 1976-02-17 1978-05-02 Eli Lilly And Company Hexahydro-dibenzo[b,d]pyran-9-ones as antiemetic drugs
US4087547A (en) 1976-02-17 1978-05-02 Eli Lilly And Company Hexahydro-dibenzo[b,d]pyran-9-ones in treatment of glaucoma
US4087546A (en) 1976-02-17 1978-05-02 Eli Lilly And Company Hexahydro-dibenzo[b,d]pyran-9-ones as antiasthmatic drugs
US4054582A (en) 1976-07-06 1977-10-18 Eli Lilly And Company Process for converting cis-hexahydrodibenzo[b,d]pyran-9-ones to trans-hexahydrodibenzo[b,d]-pyran-9-ones
US4208351A (en) 1976-11-10 1980-06-17 Eli Lilly And Company Stereoselective preparation of hexahydro dibenzopyranones and intermediates therefor
US4102902A (en) 1976-11-10 1978-07-25 Eli Lilly And Company Stereoselective preparation of hexahydro dibenzopyranones and intermediates therefor
US4176233A (en) 1976-11-10 1979-11-27 Eli Lilly And Company Stereoselective preparation of hexahydro dibenzopyranones and intermediates therefor
US4188495A (en) 1977-11-14 1980-02-12 Pfizer Inc. 1,9-Dihydroxyoctahydrophenanthrenes and intermediates therefor
US4152450A (en) 1978-02-17 1979-05-01 Eli Lilly And Company 9-Amino-dibenzopyrans
US4171315A (en) 1978-03-31 1979-10-16 Eli Lilly And Company Preparation of cis-hexahydrodibenzopyranones
IL55274A (en) 1978-08-02 1982-08-31 Yissum Res Dev Co 4-(2,6-dihydroxy-4-(dimethylheptyl)phenyl)substituted 2-pinen-10-ol and pinane derivatives,their preparation and pharmaceutical compositions comprising them
DE3025385A1 (de) 1980-07-04 1982-01-28 Boehringer Mannheim Gmbh, 6800 Mannheim Neue tricyclische arylether, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
JPS5798228A (en) 1980-12-10 1982-06-18 Hisamitsu Pharmaceut Co Inc Biphenyl derivative
US4550214A (en) 1981-01-05 1985-10-29 Polaroid Corporation Blocked vinyl biphenyl compounds
US4395560A (en) 1982-05-24 1983-07-26 Eli Lilly And Company Preparation of 6a,10a-trans-hexahydrodibenzopyranones
US4497827A (en) 1982-08-30 1985-02-05 Syntex (U.S.A.) Inc. Arachidonic acid analogues as anti-inflammatory and anti-allergic agents
US4885295A (en) 1984-08-06 1989-12-05 Sterling Drug Inc. Method of use of 3-arylcarbonyl- and 3-cycloalkyl-carbonyl-1-aminoalkyl-1H-indoles
JPS61126069A (ja) 1984-11-21 1986-06-13 Res Dev Corp Of Japan プロスタグランジン誘導体
IL80411A (en) 1986-10-24 1991-08-16 Raphael Mechoulam Preparation of dibenzopyranol derivatives and pharmaceutical compositions containing them
US4758597A (en) 1987-05-15 1988-07-19 University Patents, Inc. Carenadiol and derivatives
HU206337B (en) 1988-12-29 1992-10-28 Mitsui Petrochemical Ind Process for producing pyrimidine derivatives and pharmaceutical compositions
ES2071688T3 (es) 1989-02-08 1995-07-01 Otsuka Pharma Co Ltd Derivado bifenilico, agente reparador o protector de la degeneracion de las celulas nerviosas y proceso para preparar un derivado fenilico contenido en el agente.
JPH02304080A (ja) 1989-05-17 1990-12-17 Toyo Pharma- Kk ６Ｈ―ジベンゾ［ｂ，ｄ］ピラン―６―オン誘導体，その製法及び用途
US5521215A (en) 1989-11-07 1996-05-28 Ramot University Authority For Applied Research And Industrial Development Ltd. NMDA-blocking pharmaceuticals
US5284867A (en) 1989-11-07 1994-02-08 Yissum Research Development Company Of The Hebrew University In Jerusalem NMDA-blocking pharmaceutical compositions
US5068234A (en) 1990-02-26 1991-11-26 Sterling Drug Inc. 3-arylcarbonyl-1-(c-attached-n-heteryl)-1h-indoles
FR2665444B1 (fr) 1990-08-06 1992-11-27 Sanofi Sa Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.
US6096740A (en) 1990-11-06 2000-08-01 Ramot University Authority For Applied Research And Industrial Development Ltd. Dexanabinol derivatives and their use as neuroprotective pharmaceutical compositions
US5576436A (en) 1991-08-01 1996-11-19 Pharmaceutical Discovery Corporation Fluorescent ligands
US5635530A (en) 1991-09-12 1997-06-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem (3S,4S)-delta-6-tetrahydrocannabinol-7-oic acids and derivatives thereof, processors for their preparation and pharmaceutical compositions containing them
US5538993A (en) 1991-09-12 1996-07-23 Yissum Research Development Company Certain tetrahydrocannabinol-7-oic acid derivatives
FR2692575B1 (fr) 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
US5489580A (en) 1992-11-05 1996-02-06 University Of Connecticut Phospholipid compounds and use therefor
US5618955A (en) 1992-11-30 1997-04-08 Yissum Research Development Company Of The Hebrew University Of Jerusalem Fatty acid derivatives and pharmaceutical compositions containing same
US5440052A (en) * 1993-08-06 1995-08-08 University Of Connecticut Compositions useful as a cannabinoid receptor probe
FR2714057B1 (fr) 1993-12-17 1996-03-08 Sanofi Elf Nouveaux dérivés du 3-pyrazolecarboxamide, procédé pour leur préparation et compositions pharmaceutiques les contenant.
US5434295A (en) 1994-02-07 1995-07-18 Yissum Research Development Company Neuroprotective pharmaceutical compositions of 4-phenylpinene derivatives and certain novel 4-phenylpinene compounds
US5631297A (en) * 1994-07-11 1997-05-20 Pate; David W. Anandamides useful for the treatment of intraocular hypertension, ophthalmic compositions containing the same and methods of use of the same
US5596106A (en) 1994-07-15 1997-01-21 Eli Lilly And Company Cannabinoid receptor antagonists
US5532237A (en) 1995-02-15 1996-07-02 Merck Frosst Canada, Inc. Indole derivatives with affinity for the cannabinoid receptor
US5605906A (en) 1995-03-24 1997-02-25 Merck Frosst Canada, Inc. Cannabinoid receptor agonists
US5804601A (en) 1995-04-10 1998-09-08 Takeda Chemical Industries, Ltd. Aromatic hydroxamic acid compounds, their production and use
FR2735774B1 (fr) 1995-06-21 1997-09-12 Sanofi Sa Utilisation de composes agonistes du recepteur cb2 humain pour la preparation de medicaments immunomodulateurs, nouveaux composes agonistes du recepteur cb2 et les compositions pharmaceutiques les contenant
IL115245A (en) 1995-09-11 2002-12-01 Yissum Res Dev Co Tumor necrosis factor inhibiting pharmaceuticals
FR2741621B1 (fr) 1995-11-23 1998-02-13 Sanofi Sa Nouveaux derives de pyrazole, procede pour leur preparation et compositions pharmaceutiques en contenant
FR2742148B1 (fr) 1995-12-08 1999-10-22 Sanofi Sa Nouveaux derives du pyrazole-3-carboxamide, procede pour leur preparation et compositions pharmaceutiques les contenant
US5688825A (en) * 1996-05-31 1997-11-18 University Of Connecticut Anandamide amidase inhibitors as analgesic agents
US5760225A (en) 1996-11-15 1998-06-02 Neurogen Corporation Certain pyrazole derivatives as corticotropin-releasing factor receptor CRF1 specific ligands
DE19706903A1 (de) 1997-02-21 1998-08-27 Bayer Ag Verwendung von bekannten Agonisten des zentralen Cannabinoid-Rezeptors CB 1
US5948777A (en) 1997-03-18 1999-09-07 Smithkline Beecham Corporation Cannabinoid receptor agonists
US5925628A (en) 1997-03-31 1999-07-20 Genzyme Corporation Cationic amphiphiles for intracellular delivery of therapeutic molecules
US5939429A (en) * 1997-09-30 1999-08-17 Virginia Commonwealth University Cardiovascular uses of cannabinoid compounds
ATE247097T1 (de) 1998-05-04 2003-08-15 Univ Connecticut Analgetische und immunomodulierende cannabinoiden
CA2340444A1 (en) 1998-05-04 1999-11-11 The University Of Connecticut Cannabinoids selective for the cb2 receptor
JP2002517479A (ja) 1998-06-09 2002-06-18 ザ・ユニバ−シティ・オブ・コネチカット 鎮痛薬としてのアナンダミド輸送体阻害剤
US7897598B2 (en) 1998-06-09 2011-03-01 Alexandros Makriyannis Inhibitors of the anandamide transporter
EP1049474A4 (de) 1998-11-24 2004-12-29 Univ Connecticut Cannabimimetische lipidamide als arzneimittel
EP1226112A4 (de) 1999-10-18 2004-10-13 Univ Connecticut Retro-anandamide, cannabinoid-rezeptorliganden mit hoher affinität und stabilit ät
US7119108B1 (en) * 1999-10-18 2006-10-10 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
CA2387892A1 (en) 1999-10-18 2001-04-26 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
JP2004500342A (ja) 1999-10-18 2004-01-08 ユニバーシティ　オブ　コネチカット カンナビノイドリセプター用の新規な二環式カンナビノイド作動薬
US6900236B1 (en) * 1999-10-18 2005-05-31 University Of Connecticut Cannabimimetic indole derivatives
EP1223929B1 (de) 1999-10-18 2006-08-23 The University Of Connecticut Cannabimimetische indolderivate
AU778159B2 (en) * 1999-10-18 2004-11-18 University Of Connecticut, The Peripheral cannabinoid receptor (CB2) selective ligands
US6943266B1 (en) * 1999-10-18 2005-09-13 University Of Connecticut Bicyclic cannabinoid agonists for the cannabinoid receptor
US8084467B2 (en) * 1999-10-18 2011-12-27 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
IL132661A (en) * 1999-10-31 2008-11-26 Raphael Mechoulam Agonists specific for peripheral cannabinoid receptors
CA2399791A1 (en) 2000-02-11 2001-08-16 Bristol-Myers Squibb Company Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators in treating respiratory and non-respiratory diseases
HUP0301628A3 (en) 2000-06-22 2007-05-29 Pharmos Corp Novel non-psychotropic cannabinoids
EP1361876A4 (de) 2001-01-26 2004-03-31 Univ Connecticut Neue cannabimimetische liganden
CA2436133A1 (en) 2001-01-29 2002-08-08 University Of Connecticut Receptor selective cannabimimetic aminoalkylindoles
WO2003005960A2 (en) 2001-07-13 2003-01-23 University Of Connecticut Novel bicyclic and tricyclic cannabinoids
AU2002331766A1 (en) 2001-08-31 2003-03-18 University Of Connecticut Novel pyrazole analogs acting on cannabinoid receptors
EP1448557A4 (de) 2001-10-26 2005-02-02 Univ Connecticut Heteroindane: eine neue klasse hochwirksamer cannabimimetischer liganden
IL147941A0 (en) 2002-01-31 2002-08-14 Pharmos Corp Bicyclic cb2 cannabinoid receptor ligands
JP2005523259A (ja) 2002-01-31 2005-08-04 ファーモス コーポレイション 二環式ｃｂ２カンナビノイド受容体リガンド
CA2496097A1 (en) * 2002-08-23 2004-03-04 University Of Connecticut Keto cannabinoids with therapeutic indications
JP2005536554A (ja) 2002-08-23 2005-12-02 ユニバーシティ オブ コネチカット 新規なビフェニル及びビフェニル様カンナビノイド
US7671034B2 (en) * 2003-12-19 2010-03-02 Merial Limited Stabilized formulation of ivermectin feed premix with an extended shelf life
US6969977B1 (en) * 2004-06-10 2005-11-29 National Semiconductor Corporation Soft-start voltage regulator circuit

Also Published As

Publication number Publication date
US20010009965A1 (en) 2001-07-26
EP1075470B1 (de) 2003-08-13
DE69910373T2 (de) 2004-04-01
EP1075470A1 (de) 2001-02-14
CA2340445A1 (en) 1999-11-11
WO1999057106A1 (en) 1999-11-11
US6939977B2 (en) 2005-09-06
US20030120094A1 (en) 2003-06-26
US20050239874A1 (en) 2005-10-27
DE69910373D1 (de) 2003-09-18

Similar Documents

Publication Publication Date Title
ATE247097T1 (de) Analgetische und immunomodulierende cannabinoiden
ATE139233T1 (de) Annelierte thiophen-derivate, ihre herstellung und verwendung
YU35697A (en) Substituted 6,6-hetero-bicyclic derivatives
ES2195943T3 (es) Compuestos heteroaromaticos biciclicos y triciclicos.
DK24585D0 (da) Imidazodiazepin-derivater, deres fremstilling og anvendelse til terapeutiske formaal
IE781788L (en) Thienothiazine
YU1501A (sh) Derivati hinolina
ATE25384T1 (de) Thieno(3,2-c)pyridinderivate, verfahren zu ihrer herstellung und ihre therapeutische anwendung.
CZ110895A3 (en) 5-arylindole derivatives, intermediates for their preparation and pharmaceutical compositions based thereon
CA2205274A1 (en) Novel 2,3 disubstituted-(5,6)-heteroarylfused-pyrimidine-4-ones
PT932597E (pt) Utilizacao de amidas do acido gama-hidroxibutirico no tratamento da toxicodependencia e particularmente do alcoolismo
FI913613A0 (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten 3-aryyli-indoli- ja 3-aryyli-indatsolijohdannaisten valmistamiseksi
IE812683L (en) Thieno-pyridine derivatives
DE69313866T2 (de) Chinoxalinderivate als eaa antagonisten
PT99673A (pt) Processo para a preparacao de derivados de 1-piperazino-indano e de composicoes farmaceuticas que os contem
ID22897A (id) Turunan isoksazol
ES2140620T3 (es) Derivados de oxopiridinylquinoxalina.
EA199600007A2 (ru) Новые трициклические производные, способ их получения, способы получения оптически активных или рацемических колхицина и тиоколхицина, их аналогов или производных с использованием трициклических соединений и промежуточные продукты синтеза
ES2165067T3 (es) Nuevos derivados aromaticos sustituidos con una ribosa, su procedimiento de preparacion y su aplicacion como medicamentos.
ES2072193A1 (es) Nuevos derivados del1-fenilmetil bencimidazol piperacinas.
ATE92071T1 (de) Biphenylderivate.
MY103521A (en) Bicyclocatechol derivatives
FR2598914B1 (fr) Composition prophylactique et curative pour l'arteriosclerose
ATE148885T1 (de) Imidazopyridin-derivate und verfahren zu ihrer herstellung
DE69834853D1 (de) 1H-pyrrolo i1,2-böi1,2,4ötriazolederivate, Zwischenprodukte und Verfahren zur Herstellung von 1H-1,2,4,-triazol-5-yl Essigsäureesterderivate

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties