ATE102071T1 - REMOVAL OF PROCESS CHEMICALS FROM LABORABLE BIOLOGICAL MIXTURES BY HYDROPHOBIC EXCHANGE CHROMATOGRAPHY. - Google Patents

REMOVAL OF PROCESS CHEMICALS FROM LABORABLE BIOLOGICAL MIXTURES BY HYDROPHOBIC EXCHANGE CHROMATOGRAPHY.

Info

Publication number
ATE102071T1
ATE102071T1 AT89118199T AT89118199T ATE102071T1 AT E102071 T1 ATE102071 T1 AT E102071T1 AT 89118199 T AT89118199 T AT 89118199T AT 89118199 T AT89118199 T AT 89118199T AT E102071 T1 ATE102071 T1 AT E102071T1
Authority
AT
Austria
Prior art keywords
laborable
removal
exchange chromatography
process chemicals
biological mixtures
Prior art date
Application number
AT89118199T
Other languages
German (de)
Inventor
Richard J Bonomo
Bernard Horowitz
Original Assignee
New York Blood Center Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22971853&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE102071(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by New York Blood Center Inc filed Critical New York Blood Center Inc
Application granted granted Critical
Publication of ATE102071T1 publication Critical patent/ATE102071T1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B01D15/327—Reversed phase with hydrophobic interaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0088—Liquid substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • External Artificial Organs (AREA)
  • Steroid Compounds (AREA)
  • Fats And Perfumes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

A method of removing lipid soluble chemicals from a biological material containing the lipid soluble chemicals comprising subjecting the biological material containing the lipid soluble chemicals to hydrophobic interaction chromatography, preferably using a resin comprising octadecyl chain coupled to a silica matrix.
AT89118199T 1988-10-07 1989-09-30 REMOVAL OF PROCESS CHEMICALS FROM LABORABLE BIOLOGICAL MIXTURES BY HYDROPHOBIC EXCHANGE CHROMATOGRAPHY. ATE102071T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/256,332 US5094960A (en) 1988-10-07 1988-10-07 Removal of process chemicals from labile biological mixtures by hydrophobic interaction chromatography
EP89118199A EP0366946B1 (en) 1988-10-07 1989-09-30 Removal of process chemicals from labile biological mixtures by hydrophobic interaction chromatography

Publications (1)

Publication Number Publication Date
ATE102071T1 true ATE102071T1 (en) 1994-03-15

Family

ID=22971853

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89118199T ATE102071T1 (en) 1988-10-07 1989-09-30 REMOVAL OF PROCESS CHEMICALS FROM LABORABLE BIOLOGICAL MIXTURES BY HYDROPHOBIC EXCHANGE CHROMATOGRAPHY.

Country Status (9)

Country Link
US (1) US5094960A (en)
EP (1) EP0366946B1 (en)
JP (1) JP2799747B2 (en)
KR (1) KR970007941B1 (en)
AT (1) ATE102071T1 (en)
AU (1) AU621148B2 (en)
CA (1) CA1337052C (en)
DE (1) DE68913422T2 (en)
ES (1) ES2051951T3 (en)

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DE4008852A1 (en) * 1990-03-20 1991-09-26 Octapharma Ag METHOD FOR PRODUCING NON-INFECTIOUS BLOOD PLASMA
DE4125625C2 (en) * 1991-08-02 1999-12-02 Octapharma Ag Glarus Process for the preparation of virus-inactivated immunoglobulin solutions
DE69229272T2 (en) * 1991-09-05 2000-02-03 Baxter Int TOPICAL FIBRINOGEN COMPLEX
FR2690444B1 (en) * 1992-04-22 1995-07-13 Rucheton Marcel PROCESS FOR THE PREPARATION OF A PURIFIED PLASMATIC ALBUMIN SOLUTION.
AU667530B2 (en) * 1992-05-28 1996-03-28 New York Blood Center, Inc., The Removal of antibodies from blood-derived compositions while retaining coagulation factors
JPH06166634A (en) * 1992-12-01 1994-06-14 Green Cross Corp:The Production of plasminogen-containing composition
DE4302163A1 (en) * 1993-01-27 1994-07-28 Thomae Gmbh Dr K Process for the purification of proteins and peptides
JPH09500015A (en) * 1993-06-23 1997-01-07 ニューヨーク ブラッド センター，インコーポレイティド System for virus inactivation of blood
US6319662B1 (en) * 1993-12-17 2001-11-20 Baxter International Inc. Method and apparatus for removing viral contaminants from a body fluid
JPH08257115A (en) * 1995-03-20 1996-10-08 Kanegafuchi Chem Ind Co Ltd Adsorbent of tumor necrosis factor and adsorption removal method
US6544727B1 (en) * 1995-06-07 2003-04-08 Cerus Corporation Methods and devices for the removal of psoralens from blood products
ES2337852T3 (en) * 1995-06-07 2010-04-29 Cerus Corporation METHODS AND DEVICES FOR THE ELIMINATION OF PSORALENES FROM BLOOD PRODUCTS.
DE19544297A1 (en) 1995-11-28 1997-06-05 Behringwerke Ag Process for the removal of aromatic compounds from product-containing solutions
US5747639A (en) * 1996-03-06 1998-05-05 Amgen Boulder Inc. Use of hydrophobic interaction chromatography to purify polyethylene glycols
US20020115585A1 (en) * 1996-06-07 2002-08-22 Hei Derek J. Method and devices for the removal of psoralens from blood products
US5811403A (en) * 1996-09-30 1998-09-22 Vanderbilt University Polysaccharide toxin from Group B β-hemolytic Streptococcus (GBS) having improved purity
ES2434319T3 (en) * 1997-01-06 2013-12-16 Cerus Corporation System and method for the reduction of small organic compounds in blood products
US20010018179A1 (en) 1998-01-06 2001-08-30 Derek J. Hei Batch devices for the reduction of compounds from biological compositions containing cells and methods of use
US20010009756A1 (en) 1998-01-06 2001-07-26 Derek Hei Flow devices for the reduction of compounds from biological compositions and methods of use
US5952235A (en) * 1997-04-14 1999-09-14 Case Western Reserve University Detection of teratogen exposure
US6270952B1 (en) * 1998-01-06 2001-08-07 Cerus Corporation Methods for quenching pathogen inactivators in biological materials
US7611831B2 (en) * 1998-01-06 2009-11-03 Cerus Corporation Adsorbing pathogen-inactivating compounds with porous particles immobilized in a matrix
US6495140B1 (en) 1998-01-12 2002-12-17 Her Majesty In Right Of Canada As Represented By The Minister Of Agriculture And Agri-Food Canada Process for the isolation, recovery and purification of non-polar extractives
AT408613B (en) * 1998-06-17 2002-01-25 Immuno Ag PHARMACEUTICAL FACTOR VII PREPARATION
DE19834053A1 (en) * 1998-07-29 2000-03-30 Centeon Pharma Gmbh Methods and means for sanitizing contamination caused by viruses
IL136552A (en) 2000-06-05 2005-05-17 Omrix Biopharmaceuticals Ltd Method for the inactivation of viruses by a solvent - detergent combination and by nanofiltration
RS50891B (en) * 2003-02-13 2010-08-31 Octapharma Ag. Method for the production an albumin solution
EP1610445A4 (en) 2003-09-10 2006-01-04 Aisin Aw Co Device and method for manufacture of rotating electric machine
US6881573B2 (en) * 2003-09-12 2005-04-19 Allan L. Louderback Augmented solvent/detergent method for inactivating enveloped and non-enveloped viruses
US20060234907A1 (en) * 2004-02-13 2006-10-19 Werner Gehringer Albumin solution and process for the production thereof
DE102004009400A1 (en) 2004-02-24 2005-09-08 Zlb Behring Gmbh Fibrinogen purification
WO2006011161A2 (en) * 2004-06-29 2006-02-02 Reliance Life Sciences Pvt Ltd Process for the preparation of virus-safe biological fluids
GB0423196D0 (en) * 2004-10-19 2004-11-24 Nat Blood Authority Method
CN103961731B (en) * 2004-10-29 2017-01-18 塞鲁斯公司 Quenching methods for red blood cell inactivation process
AU2005229674B2 (en) * 2004-11-18 2010-11-04 Kedrion Melville Inc. Low concentration solvent/detergent process of immuneglobulin with pre-treatment
EP1685852A1 (en) 2005-02-01 2006-08-02 Fondation pour la Recherche Diagnostique Set of disposable bags for viral inactivation of biological fluids
WO2007054297A2 (en) * 2005-11-11 2007-05-18 Csl Behring Gmbh Use of hydrophobic interaction chromatography for the attenuation of viruses
US8480889B2 (en) * 2006-04-27 2013-07-09 Agilent Technologies, Inc. Chromatographic stationary phase
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US20080293623A1 (en) * 2007-04-30 2008-11-27 Nhs Blood And Transplant Enriched haptoglobin polymers for the treatment of disease
BRPI0911176B8 (en) 2008-04-09 2021-05-25 Cerus Corp method of treating a red blood cell composition, red blood cell composition, and method of reducing dehydration in a red blood cell composition
WO2010117598A2 (en) * 2009-03-31 2010-10-14 3M Innovative Properties Company Hydrophobic monomers, hydrophobically-derivatized supports, and methods of making and using the same
WO2012066569A1 (en) * 2010-11-16 2012-05-24 Cadila Healthcare Limited A novel process for the purification of tissue plasminogen activator
IL210162A0 (en) 2010-12-21 2011-03-31 Omrix Biopharmaceuticals Viral inactivated platelet extract, use and preparation thereof
US20130172536A1 (en) * 2011-08-16 2013-07-04 Shenzhen Weiguang Biological Products Co.,Ltd. Intravenous Cytomegalovirus Human Immune Globulin and Manufacturing Method Thereof
CH706420A1 (en) * 2012-04-19 2013-10-31 Valerie Soulie Method for the viral inactivation of a biological fluid, device and container for carrying & oelig; piece of such a method.
CA2895652C (en) 2012-12-20 2020-10-27 Omrix Biopharmaceuticals Ltd. Viral inactivated biological mixture
EP3808841A1 (en) 2015-02-06 2021-04-21 Guangzhou Bioseal Biotech Co., Ltd. Method for preparation of thrombin

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US4909940A (en) 1987-12-30 1990-03-20 New York Blood Center, Inc. Extraction of process chemicals from labile biological mixtures with organic alcohols or with halogenated hydrocarbons

Also Published As

Publication number Publication date
EP0366946A1 (en) 1990-05-09
DE68913422T2 (en) 1994-06-01
KR900006010A (en) 1990-05-07
CA1337052C (en) 1995-09-19
DE68913422D1 (en) 1994-04-07
JPH02198561A (en) 1990-08-07
ES2051951T3 (en) 1994-07-01
AU621148B2 (en) 1992-03-05
AU4155989A (en) 1990-09-13
EP0366946B1 (en) 1994-03-02
KR970007941B1 (en) 1997-05-19
JP2799747B2 (en) 1998-09-21
US5094960A (en) 1992-03-10

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time