ZW986A1 - Aminophenol derivatives - Google Patents

Aminophenol derivatives

Info

Publication number
ZW986A1
ZW986A1 ZW9/86A ZW986A ZW986A1 ZW 986 A1 ZW986 A1 ZW 986A1 ZW 9/86 A ZW9/86 A ZW 9/86A ZW 986 A ZW986 A ZW 986A ZW 986 A1 ZW986 A1 ZW 986A1
Authority
ZW
Zimbabwe
Prior art keywords
sub
sup
group
alkyl
hydrogen atom
Prior art date
Application number
ZW9/86A
Inventor
Frederick Skidmore Ian
Henry Charles Lunts Lawrence
Finch Harry
Naylor Alan
Baxter Campbell Ian
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ZW986A1 publication Critical patent/ZW986A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

The invention provides compounds of the general formula (I)whereinAr represents a phenyl group optionally substituted by one or more substituents selected from halogen atoms, or the groups C<sub>1-6</sub> alkyl, C<sub>1-6</sub> alkoxy, nitro, -(CH<sub>2</sub>)<sub>q</sub>R, [where R is hydroxy, -NR<sup>3</sup>R<sup>4</sup> (where R<sup>3</sup> and R<sup>4</sup> each represents a hydrogen atom, or a C<sub>1-4</sub> alkyl group, or-NR<sup>3</sup>R<sup>4</sup> forms a saturated heterocyclic amino group which has 5-7 ring members and optionally contains in the ring one or more atoms selected from -0- or -S- or a group -NH- or -N(CH<sub>3</sub>)-). -NR<sup>5</sup>COR<sup>6</sup> (where R<sup>5</sup> represents a hydrogen atom or a C<sub>1-5</sub> alkyl group, and R<sup>6</sup> represents a hydrogen atom or a C<sub>1-4</sub> alkyl, C<sub>1-4</sub> alkoxy, phenyl or-NR<sup>3</sup>R<sup>4</sup> group), -NR<sup>6</sup>SO<sub>2</sub>R<sup>7</sup> (where R<sup>7</sup> represents a C<sub>1-4</sub> alkyl, phenyl or -NR<sup>3</sup>R<sup>4</sup> group), -COR<sup>8</sup> (where R<sup>8</sup> represents hydroxy, C<sub>1-4</sub> alkoxy or-NR<sup>3</sup>R<sup>4</sup>), -SR<sup>8</sup> (where R<sup>9</sup> is a hydrogen atom, or a C<sub>1-4</sub> alkyl or phenyl group),-SOR<sup>9</sup>,-SO<sub>2</sub>R<sup>9</sup>, or -CN, and q represents an integer from 0 to 31, -(CH<sub>2</sub>)<sub>r</sub>R<sup>10</sup>, [where R<sup>10</sup> is a C<sub>1-4</sub> alkoxy group and r represents an integer from 1 to 3] or -O(CH<sub>2</sub>)<sub>t</sub>T<sup>11</sup> [where R" represents a hydroxy or C<sub>1-4</sub> alkoxy group and t is 2 or 3] or Ar is a phenyl group substituted by an alkylenedioxy group of formula -O(CH<sub>2</sub>)<sub>p</sub>O-, where p represents 1 or 2; R' and R<sup>2</sup> each represent a hydrogen atom or a C<sub>1-3</sub> alkyl group with the proviso that the sum total of carbon atoms inR<sup>1</sup> and R<sup>2</sup> is not more than 4;X represents a C<sub>1-7</sub> alkylene, C<sub>2</sub> alkenylene or C<sub>2-7</sub> alkynylene chain;Y represents a bond, or a C<sub>1-6</sub> alkylene, C<sub>2-6</sub> alkenylene or C<sub>2-6</sub> alkynylene chain with the proviso that the sum total of carbon atoms in X and Y is 2 to 10;Q represents a group R<sup>12</sup>CO-, R<sup>12</sup>NHCO-, R<sup>12</sup>R<sup>13</sup>NSO<sub>2</sub>- or R<sup>14</sup>SO<sub>2</sub>, where R<sup>12</sup> and R<sup>13</sup> each represents a hydrogen atom or a C<sub>1-3</sub> alkyl group, and R<sup>14</sup> represents a C<sub>1-4</sub> alkyl group, with the proviso that when X represents C<sub>1-7</sub> alkylene, and Y represents a bond or C<sub>1-6</sub> alkylene, then the group Ar does not represent an unsubstituted phenyl group or a phenyl group substituted by one or more substituents selected solely from halogen atoms or C<sub>1-6</sub> alkyl or C<sub>1-6</sub> alkoxy groups or an alkylenedioxy group -O(CH<sub>2</sub>)<sub>p</sub>O-;and physiologically acceptable salts and solvates thereof.The compounds have a selective stimulant action at β<sub>2</sub>-adrenoreceptors and may be used, inter alia, in the treatment of disease associated with reversible airways obstruction such as asthma and chronic bronchitis.
ZW9/86A 1984-10-17 1986-01-10 Aminophenol derivatives ZW986A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848426200A GB8426200D0 (en) 1984-10-17 1984-10-17 Chemical compounds

Publications (1)

Publication Number Publication Date
ZW986A1 true ZW986A1 (en) 1986-05-14

Family

ID=10568301

Family Applications (1)

Application Number Title Priority Date Filing Date
ZW9/86A ZW986A1 (en) 1984-10-17 1986-01-10 Aminophenol derivatives

Country Status (11)

Country Link
US (2) US4730008A (en)
EP (1) EP0178919B1 (en)
JP (1) JPS61148150A (en)
CN (1) CN1016246B (en)
AT (1) ATE39350T1 (en)
DE (1) DE3566885D1 (en)
DK (1) DK13186A (en)
FI (1) FI85371C (en)
GB (1) GB8426200D0 (en)
PT (1) PT81819B (en)
ZW (1) ZW986A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0220054A3 (en) * 1985-10-16 1987-12-02 Glaxo Group Limited Ethanolamine derivatives
EP0286242A3 (en) * 1987-03-12 1989-08-09 Glaxo Group Limited Ethanolamine derivates, processes for their preparation and pharmaceutical compositions containing them
GB8718940D0 (en) * 1987-08-11 1987-09-16 Glaxo Group Ltd Chemical compounds
GB8718938D0 (en) * 1987-08-11 1987-09-16 Glaxo Group Ltd Chemical compounds
EP0317206B1 (en) * 1987-11-13 1993-04-28 Glaxo Group Limited Phenethanolamine derivatives
AU613687B2 (en) * 1987-12-18 1991-08-08 Glaxo Group Limited Ethanolamine derivatives
ZA889405B (en) * 1987-12-18 1989-12-27 Glaxo Group Ltd Ethanolamine derivatives
DK702188A (en) * 1987-12-18 1989-06-19 Glaxo Group Ltd ETHANOLAMINE DERIVATIVES
DE3743265A1 (en) * 1987-12-19 1989-06-29 Boehringer Ingelheim Kg NEW AMMONIUM COMPOUNDS, THEIR MANUFACTURE AND USE
IE914003A1 (en) * 1990-11-20 1992-05-20 Astra Pharma Prod Biologically Active Amines
EP0581907A1 (en) * 1991-04-18 1994-02-09 The University Of Georgia Research Foundation, Inc. Inhibitors of kynureninase
US5495044A (en) * 1991-04-18 1996-02-27 University Of Georgia Research Foundation, Inc. Inhibitors of kynureninase
TW356468B (en) * 1995-09-15 1999-04-21 Astra Pharma Prod Benzothiazolone compounds useful as beta2-adrenoreceptor and dopamine DA2 receptor agonists process for preparing same and pharmaceutical compositions containing same
GB9526511D0 (en) * 1995-12-23 1996-02-28 Astra Pharma Prod Pharmaceutically active compounds
GB0103630D0 (en) * 2001-02-14 2001-03-28 Glaxo Group Ltd Chemical compounds
ES2296923T3 (en) * 2001-03-22 2008-05-01 Glaxo Group Limited FORMANILID DERIVATIVES AS AGONISTS OF THE BETA2 ADRENORRECEPTOR.
PL211953B1 (en) * 2001-09-14 2012-07-31 Glaxo Group Ltd Phenethanolamine derivatives for treatment of respiratory diseases
GB0217225D0 (en) 2002-07-25 2002-09-04 Glaxo Group Ltd Medicinal compounds
GB0303396D0 (en) * 2003-02-14 2003-03-19 Glaxo Group Ltd Medicinal compounds
CA2569395A1 (en) * 2004-06-03 2005-12-22 Theravance, Inc. Diamine .beta.2 adrenergic receptor agonists

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR9400E (en) * 1906-08-22 1908-10-19 Ernest Renaudin Hand baling and binding machine with continuous twine feed
FR152F (en) * 1962-01-24
FR148F (en) * 1962-01-24
FR4290M (en) * 1964-06-05 1966-07-18
US3337546A (en) * 1964-09-09 1967-08-22 Hoffmann La Roche Certain 1, 3 oxazines and a process for their preparation
GB1214012A (en) * 1967-12-21 1970-11-25 Allen & Hanburys Ltd Phenylethanolamines
ZA71417B (en) * 1970-02-17 1971-10-27 Smith Kleine & French Labor A-aminoalkyl-4-hydroxy-3-ureidobenzyl alcohols
AT310146B (en) * 1971-04-26 1973-09-25 Boehringer Sohn Ingelheim Process for the production of new N, N'-bis- (β-hydroxyarylethyl) -diaminoalkanes and their acid addition salts
GB1531718A (en) * 1974-11-20 1978-11-08 Pharmacia As Phenylethanolamines
US4146638A (en) * 1976-02-17 1979-03-27 Boehringer Ingelheim Gmbh N-(3-phenoxy-2-hydroxy-propyl)-n-(2-phenyl-2-hydroxy-ethyl)-amines
ATE1899T1 (en) * 1979-06-16 1982-12-15 Beecham Group Plc SECONDARY AMINES, THEIR PRODUCTION AND USE IN PHARMACEUTICAL COMPOSITIONS.
SE8503466L (en) * 1984-07-13 1986-01-14 Glaxo Group Ltd aminophenol compounds

Also Published As

Publication number Publication date
DK13186A (en) 1987-07-11
EP0178919A2 (en) 1986-04-23
JPS61148150A (en) 1986-07-05
JPH0474345B2 (en) 1992-11-26
EP0178919B1 (en) 1988-12-21
US4853382A (en) 1989-08-01
ATE39350T1 (en) 1989-01-15
FI85371B (en) 1991-12-31
FI85371C (en) 1992-04-10
FI860107A0 (en) 1986-01-10
FI860107A (en) 1987-07-11
US4730008A (en) 1988-03-08
DK13186D0 (en) 1986-01-10
CN1016246B (en) 1992-04-15
GB8426200D0 (en) 1984-11-21
EP0178919A3 (en) 1987-08-05
PT81819A (en) 1986-02-01
DE3566885D1 (en) 1989-01-26
CN86102681A (en) 1987-10-28
PT81819B (en) 1988-05-27

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