ZW986A1 - Aminophenol derivatives - Google Patents
Aminophenol derivativesInfo
- Publication number
- ZW986A1 ZW986A1 ZW9/86A ZW986A ZW986A1 ZW 986 A1 ZW986 A1 ZW 986A1 ZW 9/86 A ZW9/86 A ZW 9/86A ZW 986 A ZW986 A ZW 986A ZW 986 A1 ZW986 A1 ZW 986A1
- Authority
- ZW
- Zimbabwe
- Prior art keywords
- sub
- sup
- group
- alkyl
- hydrogen atom
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
The invention provides compounds of the general formula (I)whereinAr represents a phenyl group optionally substituted by one or more substituents selected from halogen atoms, or the groups C<sub>1-6</sub> alkyl, C<sub>1-6</sub> alkoxy, nitro, -(CH<sub>2</sub>)<sub>q</sub>R, [where R is hydroxy, -NR<sup>3</sup>R<sup>4</sup> (where R<sup>3</sup> and R<sup>4</sup> each represents a hydrogen atom, or a C<sub>1-4</sub> alkyl group, or-NR<sup>3</sup>R<sup>4</sup> forms a saturated heterocyclic amino group which has 5-7 ring members and optionally contains in the ring one or more atoms selected from -0- or -S- or a group -NH- or -N(CH<sub>3</sub>)-). -NR<sup>5</sup>COR<sup>6</sup> (where R<sup>5</sup> represents a hydrogen atom or a C<sub>1-5</sub> alkyl group, and R<sup>6</sup> represents a hydrogen atom or a C<sub>1-4</sub> alkyl, C<sub>1-4</sub> alkoxy, phenyl or-NR<sup>3</sup>R<sup>4</sup> group), -NR<sup>6</sup>SO<sub>2</sub>R<sup>7</sup> (where R<sup>7</sup> represents a C<sub>1-4</sub> alkyl, phenyl or -NR<sup>3</sup>R<sup>4</sup> group), -COR<sup>8</sup> (where R<sup>8</sup> represents hydroxy, C<sub>1-4</sub> alkoxy or-NR<sup>3</sup>R<sup>4</sup>), -SR<sup>8</sup> (where R<sup>9</sup> is a hydrogen atom, or a C<sub>1-4</sub> alkyl or phenyl group),-SOR<sup>9</sup>,-SO<sub>2</sub>R<sup>9</sup>, or -CN, and q represents an integer from 0 to 31, -(CH<sub>2</sub>)<sub>r</sub>R<sup>10</sup>, [where R<sup>10</sup> is a C<sub>1-4</sub> alkoxy group and r represents an integer from 1 to 3] or -O(CH<sub>2</sub>)<sub>t</sub>T<sup>11</sup> [where R" represents a hydroxy or C<sub>1-4</sub> alkoxy group and t is 2 or 3] or Ar is a phenyl group substituted by an alkylenedioxy group of formula -O(CH<sub>2</sub>)<sub>p</sub>O-, where p represents 1 or 2; R' and R<sup>2</sup> each represent a hydrogen atom or a C<sub>1-3</sub> alkyl group with the proviso that the sum total of carbon atoms inR<sup>1</sup> and R<sup>2</sup> is not more than 4;X represents a C<sub>1-7</sub> alkylene, C<sub>2</sub> alkenylene or C<sub>2-7</sub> alkynylene chain;Y represents a bond, or a C<sub>1-6</sub> alkylene, C<sub>2-6</sub> alkenylene or C<sub>2-6</sub> alkynylene chain with the proviso that the sum total of carbon atoms in X and Y is 2 to 10;Q represents a group R<sup>12</sup>CO-, R<sup>12</sup>NHCO-, R<sup>12</sup>R<sup>13</sup>NSO<sub>2</sub>- or R<sup>14</sup>SO<sub>2</sub>, where R<sup>12</sup> and R<sup>13</sup> each represents a hydrogen atom or a C<sub>1-3</sub> alkyl group, and R<sup>14</sup> represents a C<sub>1-4</sub> alkyl group, with the proviso that when X represents C<sub>1-7</sub> alkylene, and Y represents a bond or C<sub>1-6</sub> alkylene, then the group Ar does not represent an unsubstituted phenyl group or a phenyl group substituted by one or more substituents selected solely from halogen atoms or C<sub>1-6</sub> alkyl or C<sub>1-6</sub> alkoxy groups or an alkylenedioxy group -O(CH<sub>2</sub>)<sub>p</sub>O-;and physiologically acceptable salts and solvates thereof.The compounds have a selective stimulant action at β<sub>2</sub>-adrenoreceptors and may be used, inter alia, in the treatment of disease associated with reversible airways obstruction such as asthma and chronic bronchitis.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB848426200A GB8426200D0 (en) | 1984-10-17 | 1984-10-17 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ZW986A1 true ZW986A1 (en) | 1986-05-14 |
Family
ID=10568301
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZW9/86A ZW986A1 (en) | 1984-10-17 | 1986-01-10 | Aminophenol derivatives |
Country Status (11)
Country | Link |
---|---|
US (2) | US4730008A (en) |
EP (1) | EP0178919B1 (en) |
JP (1) | JPS61148150A (en) |
CN (1) | CN1016246B (en) |
AT (1) | ATE39350T1 (en) |
DE (1) | DE3566885D1 (en) |
DK (1) | DK13186A (en) |
FI (1) | FI85371C (en) |
GB (1) | GB8426200D0 (en) |
PT (1) | PT81819B (en) |
ZW (1) | ZW986A1 (en) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0220054A3 (en) * | 1985-10-16 | 1987-12-02 | Glaxo Group Limited | Ethanolamine derivatives |
EP0286242A3 (en) * | 1987-03-12 | 1989-08-09 | Glaxo Group Limited | Ethanolamine derivates, processes for their preparation and pharmaceutical compositions containing them |
GB8718940D0 (en) * | 1987-08-11 | 1987-09-16 | Glaxo Group Ltd | Chemical compounds |
GB8718938D0 (en) * | 1987-08-11 | 1987-09-16 | Glaxo Group Ltd | Chemical compounds |
EP0317206B1 (en) * | 1987-11-13 | 1993-04-28 | Glaxo Group Limited | Phenethanolamine derivatives |
AU613687B2 (en) * | 1987-12-18 | 1991-08-08 | Glaxo Group Limited | Ethanolamine derivatives |
ZA889405B (en) * | 1987-12-18 | 1989-12-27 | Glaxo Group Ltd | Ethanolamine derivatives |
DK702188A (en) * | 1987-12-18 | 1989-06-19 | Glaxo Group Ltd | ETHANOLAMINE DERIVATIVES |
DE3743265A1 (en) * | 1987-12-19 | 1989-06-29 | Boehringer Ingelheim Kg | NEW AMMONIUM COMPOUNDS, THEIR MANUFACTURE AND USE |
IE914003A1 (en) * | 1990-11-20 | 1992-05-20 | Astra Pharma Prod | Biologically Active Amines |
EP0581907A1 (en) * | 1991-04-18 | 1994-02-09 | The University Of Georgia Research Foundation, Inc. | Inhibitors of kynureninase |
US5495044A (en) * | 1991-04-18 | 1996-02-27 | University Of Georgia Research Foundation, Inc. | Inhibitors of kynureninase |
TW356468B (en) * | 1995-09-15 | 1999-04-21 | Astra Pharma Prod | Benzothiazolone compounds useful as beta2-adrenoreceptor and dopamine DA2 receptor agonists process for preparing same and pharmaceutical compositions containing same |
GB9526511D0 (en) * | 1995-12-23 | 1996-02-28 | Astra Pharma Prod | Pharmaceutically active compounds |
GB0103630D0 (en) * | 2001-02-14 | 2001-03-28 | Glaxo Group Ltd | Chemical compounds |
ES2296923T3 (en) * | 2001-03-22 | 2008-05-01 | Glaxo Group Limited | FORMANILID DERIVATIVES AS AGONISTS OF THE BETA2 ADRENORRECEPTOR. |
PL211953B1 (en) * | 2001-09-14 | 2012-07-31 | Glaxo Group Ltd | Phenethanolamine derivatives for treatment of respiratory diseases |
GB0217225D0 (en) | 2002-07-25 | 2002-09-04 | Glaxo Group Ltd | Medicinal compounds |
GB0303396D0 (en) * | 2003-02-14 | 2003-03-19 | Glaxo Group Ltd | Medicinal compounds |
CA2569395A1 (en) * | 2004-06-03 | 2005-12-22 | Theravance, Inc. | Diamine .beta.2 adrenergic receptor agonists |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR9400E (en) * | 1906-08-22 | 1908-10-19 | Ernest Renaudin | Hand baling and binding machine with continuous twine feed |
FR152F (en) * | 1962-01-24 | |||
FR148F (en) * | 1962-01-24 | |||
FR4290M (en) * | 1964-06-05 | 1966-07-18 | ||
US3337546A (en) * | 1964-09-09 | 1967-08-22 | Hoffmann La Roche | Certain 1, 3 oxazines and a process for their preparation |
GB1214012A (en) * | 1967-12-21 | 1970-11-25 | Allen & Hanburys Ltd | Phenylethanolamines |
ZA71417B (en) * | 1970-02-17 | 1971-10-27 | Smith Kleine & French Labor | A-aminoalkyl-4-hydroxy-3-ureidobenzyl alcohols |
AT310146B (en) * | 1971-04-26 | 1973-09-25 | Boehringer Sohn Ingelheim | Process for the production of new N, N'-bis- (β-hydroxyarylethyl) -diaminoalkanes and their acid addition salts |
GB1531718A (en) * | 1974-11-20 | 1978-11-08 | Pharmacia As | Phenylethanolamines |
US4146638A (en) * | 1976-02-17 | 1979-03-27 | Boehringer Ingelheim Gmbh | N-(3-phenoxy-2-hydroxy-propyl)-n-(2-phenyl-2-hydroxy-ethyl)-amines |
ATE1899T1 (en) * | 1979-06-16 | 1982-12-15 | Beecham Group Plc | SECONDARY AMINES, THEIR PRODUCTION AND USE IN PHARMACEUTICAL COMPOSITIONS. |
SE8503466L (en) * | 1984-07-13 | 1986-01-14 | Glaxo Group Ltd | aminophenol compounds |
-
1984
- 1984-10-17 GB GB848426200A patent/GB8426200D0/en active Pending
-
1985
- 1985-10-16 DE DE8585307450T patent/DE3566885D1/en not_active Expired
- 1985-10-16 AT AT85307450T patent/ATE39350T1/en not_active IP Right Cessation
- 1985-10-16 EP EP85307450A patent/EP0178919B1/en not_active Expired
- 1985-10-17 JP JP60232289A patent/JPS61148150A/en active Granted
-
1986
- 1986-01-10 US US06/817,676 patent/US4730008A/en not_active Expired - Fee Related
- 1986-01-10 ZW ZW9/86A patent/ZW986A1/en unknown
- 1986-01-10 PT PT81819A patent/PT81819B/en not_active IP Right Cessation
- 1986-01-10 FI FI860107A patent/FI85371C/en not_active IP Right Cessation
- 1986-01-10 DK DK013186A patent/DK13186A/en not_active Application Discontinuation
- 1986-04-15 CN CN86102681A patent/CN1016246B/en not_active Expired
-
1987
- 1987-11-24 US US07/124,601 patent/US4853382A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DK13186A (en) | 1987-07-11 |
EP0178919A2 (en) | 1986-04-23 |
JPS61148150A (en) | 1986-07-05 |
JPH0474345B2 (en) | 1992-11-26 |
EP0178919B1 (en) | 1988-12-21 |
US4853382A (en) | 1989-08-01 |
ATE39350T1 (en) | 1989-01-15 |
FI85371B (en) | 1991-12-31 |
FI85371C (en) | 1992-04-10 |
FI860107A0 (en) | 1986-01-10 |
FI860107A (en) | 1987-07-11 |
US4730008A (en) | 1988-03-08 |
DK13186D0 (en) | 1986-01-10 |
CN1016246B (en) | 1992-04-15 |
GB8426200D0 (en) | 1984-11-21 |
EP0178919A3 (en) | 1987-08-05 |
PT81819A (en) | 1986-02-01 |
DE3566885D1 (en) | 1989-01-26 |
CN86102681A (en) | 1987-10-28 |
PT81819B (en) | 1988-05-27 |
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