ZM482A1 - Imidazodiazepines - Google Patents
ImidazodiazepinesInfo
- Publication number
- ZM482A1 ZM482A1 ZM4/82A ZM482A ZM482A1 ZM 482 A1 ZM482 A1 ZM 482A1 ZM 4/82 A ZM4/82 A ZM 4/82A ZM 482 A ZM482 A ZM 482A ZM 482 A1 ZM482 A1 ZM 482A1
- Authority
- ZM
- Zambia
- Prior art keywords
- hydrogen
- imidazodiazepines
- benzodiazepines
- trifluoromethyl
- cyano
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
There is provided imidazodiazepines of the formula <IMAGE> 1 wherein A together with the two carbon atoms denoted as alpha and beta is the group <IMAGE> X is an oxygen or sulphur atom and R1 is hydrogen or lower alkyl, and either R2 is hydrogen, trifluoromethyl, halogen, cyano or nitro and R3 is hydrogen or R2 is hydrogen and R3 is trifluoromethyl, halogen, cyano, nitro or lower alkyl, and their pharmaceutically acceptable acid addition salts. The compounds are useful in the antagonization of the central-depressant, muscle relaxant, ataxic, blood pressure-lowering and respiratory-depressant properties of 1,4-benzodiazepines which have tranquillizing activity, for example as antidotes in the case of intoxications with 1,4-benzodiazepines which have tranquillizing activity. Also presented are methods to produce the above imidazodiazepines.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH134081 | 1981-02-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZM482A1 true ZM482A1 (en) | 1982-11-22 |
Family
ID=4208189
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZM4/82A ZM482A1 (en) | 1981-02-27 | 1982-01-28 | Imidazodiazepines |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US4352817A (en) |
| EP (1) | EP0059389B1 (en) |
| JP (1) | JPS57156488A (en) |
| KR (1) | KR830009104A (en) |
| AT (1) | ATE10745T1 (en) |
| AU (1) | AU551811B2 (en) |
| BR (1) | BR8200949A (en) |
| CA (1) | CA1184176A (en) |
| DE (1) | DE3261496D1 (en) |
| DK (1) | DK87182A (en) |
| ES (3) | ES8304982A1 (en) |
| FI (1) | FI73431C (en) |
| GB (1) | GB2093842B (en) |
| GR (1) | GR76032B (en) |
| HU (1) | HU185089B (en) |
| IE (1) | IE52696B1 (en) |
| IL (1) | IL65072A (en) |
| MC (1) | MC1441A1 (en) |
| NO (1) | NO157377C (en) |
| NZ (1) | NZ199796A (en) |
| OA (1) | OA07010A (en) |
| PH (1) | PH18255A (en) |
| PT (1) | PT74505B (en) |
| YU (1) | YU25282A (en) |
| ZA (1) | ZA821129B (en) |
| ZM (1) | ZM482A1 (en) |
| ZW (1) | ZW3082A1 (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MC1528A1 (en) * | 1982-07-21 | 1984-04-13 | Hoffmann La Roche | IMIDAZOBENZODIAZEPINES |
| DK151808C (en) * | 1982-11-16 | 1988-06-20 | Ferrosan As | ANALOGY PROCEDURE FOR THE PREPARATION OF OXADIAZOLYLIMIDAZO-OE1,4AA-BENZODIAZEPINE DERIVATIVES |
| NZ210850A (en) * | 1984-01-19 | 1988-10-28 | Hoffmann La Roche | Imidazodiazepine derivatives and pharmaceutical compositions |
| EP0212825B1 (en) * | 1985-07-09 | 1993-09-29 | Nippon Petrochemicals Company, Limited | Flame-retardant olefin polymer composition |
| DE3763015D1 (en) * | 1986-03-03 | 1990-07-12 | Ube Industries | VERTICAL INJECTION MOLDING MACHINE. |
| ZA881538B (en) * | 1987-03-10 | 1988-09-12 | F. Hoffmann-La Roche & Co. Aktiengesellschaft | Imidazodiazepine derivatives |
| CA1327008C (en) * | 1988-01-15 | 1994-02-15 | Walter Merz | Anti-psychotic imidazobenzodiazepine |
| CA1318668C (en) * | 1988-08-05 | 1993-06-01 | Heinz Carmann | Radioiodine benzodiazepine derivatives |
| US5096695A (en) * | 1988-08-05 | 1992-03-17 | Hoffmann-Laroche Inc. | Radioiodine benzodiazepines as brain imaging agents |
| CA1327572C (en) * | 1988-08-31 | 1994-03-08 | F. Hoffmann-La Roche Ag | Imidazodiazepine derivatives |
| CA2015336A1 (en) * | 1989-05-19 | 1990-11-19 | F. Hoffmann-La Roche Ag | Imidazodiazepines for the treatment of neurological symptoms |
| US5109013A (en) * | 1990-06-06 | 1992-04-28 | A. H. Robins Company, Incorporated | 2-(2-substituted aminoethyl)-1,4-dialkyl-3,4-dihydro-1H-1,3,5]triazepino[3,2-a]benzimidazol-5(2H)-ones as muscle relaxants |
| US5438035A (en) * | 1994-06-24 | 1995-08-01 | American Cyanamid Company | Methods for controlling undesirable plant species with benzodiazepine compounds |
| JO2259B1 (en) * | 1999-05-12 | 2004-10-07 | اف. هوفمان- لاروش أيه جي | Process for manufacturing diazepine derivatives |
| US7595395B2 (en) * | 2005-05-16 | 2009-09-29 | Wisys Technology Foundation | Gabaergic agents to treat memory deficits |
| KR101589314B1 (en) * | 2007-08-20 | 2016-01-28 | 에보텍 인터내셔널 게엠베하 | Treatment of sleep disorders |
| US20090054412A1 (en) * | 2007-08-20 | 2009-02-26 | John Alan Kemp | Treatment of Sleep Disorders |
| CN113087713B (en) * | 2021-03-29 | 2022-10-04 | 中国人民解放军军事科学院军事医学研究院 | Benzodiazepine derivatives, and preparation method and use thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU509371B2 (en) * | 1975-08-07 | 1980-05-08 | F. Hoffmann-La Roche Ag | Diazepine Derivatives |
| GB1600600A (en) * | 1977-03-10 | 1981-10-21 | Diamond Shamrock Chem | Plasticiser compositions for use with synthetic resin polymers |
| US4118386A (en) * | 1977-04-04 | 1978-10-03 | Hoffmann-La Roche Inc. | Synthesis of imidazo[1,5-a]diazepine-3-carboxylates |
| CA1143728A (en) * | 1979-10-04 | 1983-03-29 | Max Gerecke | Imidazodiazepine derivatives |
-
1981
- 1981-02-18 US US06/349,802 patent/US4352817A/en not_active Expired - Fee Related
-
1982
- 1982-01-08 CA CA000393844A patent/CA1184176A/en not_active Expired
- 1982-01-22 FI FI820199A patent/FI73431C/en not_active IP Right Cessation
- 1982-01-28 ZM ZM4/82A patent/ZM482A1/en unknown
- 1982-02-02 OA OA57605A patent/OA07010A/en unknown
- 1982-02-05 YU YU00252/82A patent/YU25282A/en unknown
- 1982-02-05 PH PH26830A patent/PH18255A/en unknown
- 1982-02-19 ZW ZW30/82A patent/ZW3082A1/en unknown
- 1982-02-19 ZA ZA821129A patent/ZA821129B/en unknown
- 1982-02-19 AT AT82101271T patent/ATE10745T1/en not_active IP Right Cessation
- 1982-02-19 DE DE8282101271T patent/DE3261496D1/en not_active Expired
- 1982-02-19 BR BR8200949A patent/BR8200949A/en unknown
- 1982-02-19 EP EP82101271A patent/EP0059389B1/en not_active Expired
- 1982-02-22 AU AU80666/82A patent/AU551811B2/en not_active Ceased
- 1982-02-22 IL IL65072A patent/IL65072A/en unknown
- 1982-02-22 NZ NZ199796A patent/NZ199796A/en unknown
- 1982-02-24 HU HU82553A patent/HU185089B/en unknown
- 1982-02-25 MC MC821576A patent/MC1441A1/en unknown
- 1982-02-25 GR GR67412A patent/GR76032B/el unknown
- 1982-02-26 KR KR1019820000861A patent/KR830009104A/en unknown
- 1982-02-26 JP JP57029101A patent/JPS57156488A/en active Pending
- 1982-02-26 DK DK87182A patent/DK87182A/en not_active Application Discontinuation
- 1982-02-26 ES ES509924A patent/ES8304982A1/en not_active Expired
- 1982-02-26 GB GB8205670A patent/GB2093842B/en not_active Expired
- 1982-02-26 NO NO820623A patent/NO157377C/en unknown
- 1982-02-26 IE IE420/82A patent/IE52696B1/en unknown
- 1982-02-26 PT PT74505A patent/PT74505B/en unknown
- 1982-12-16 ES ES518262A patent/ES8405008A1/en not_active Expired
- 1982-12-16 ES ES518263A patent/ES518263A0/en active Granted
Also Published As
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