ZA991745B - Combination of a selective NMDA NR2B antagonist and an opioid analgesic. - Google Patents

Combination of a selective NMDA NR2B antagonist and an opioid analgesic.

Info

Publication number
ZA991745B
ZA991745B ZA9901745A ZA991745A ZA991745B ZA 991745 B ZA991745 B ZA 991745B ZA 9901745 A ZA9901745 A ZA 9901745A ZA 991745 A ZA991745 A ZA 991745A ZA 991745 B ZA991745 B ZA 991745B
Authority
ZA
South Africa
Prior art keywords
combination
opioid analgesic
selective nmda
nr2b antagonist
nmda nr2b
Prior art date
Application number
ZA9901745A
Other languages
English (en)
Inventor
Susan Boyce
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of ZA991745B publication Critical patent/ZA991745B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA9901745A 1998-03-06 1999-03-04 Combination of a selective NMDA NR2B antagonist and an opioid analgesic. ZA991745B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9804885.3A GB9804885D0 (en) 1998-03-06 1998-03-06 Therapeutic combination

Publications (1)

Publication Number Publication Date
ZA991745B true ZA991745B (en) 1999-09-06

Family

ID=10828172

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9901745A ZA991745B (en) 1998-03-06 1999-03-04 Combination of a selective NMDA NR2B antagonist and an opioid analgesic.

Country Status (8)

Country Link
US (1) US6538008B1 (xx)
EP (1) EP1059923A1 (xx)
JP (1) JP2002505287A (xx)
AU (1) AU3260099A (xx)
CA (1) CA2321685A1 (xx)
GB (1) GB9804885D0 (xx)
WO (1) WO1999044610A1 (xx)
ZA (1) ZA991745B (xx)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5900420A (en) * 1997-06-19 1999-05-04 Cole; William L. Method for treating chronic fatigue syndrome and fibromyalgia with buprenorphine
CA2370030C (en) 1999-04-09 2007-08-14 Euro-Celtique S.A. Sodium channel blocker compositions and the use thereof
WO2001052851A1 (en) * 2000-01-22 2001-07-26 Albert Shulman Methods for the treatment of substance abuse
EP1186303A3 (en) * 2000-09-06 2003-12-10 Pfizer Products Inc. Pharmaceutical combinations, for the treatment of stroke and traumatic brain injury, containing a neutrophil inhibiting factor and an selective NMDA-NR2B receptor antagonist
IL145584A0 (en) 2000-10-02 2002-06-30 Pfizer Prod Inc Nmda nr2b antagonists for treatment
ZA200108038B (en) * 2000-10-02 2003-04-01 Pfizer Prod Inc Prophylactic use of n-methyl-d-asparrate (NMDA) antagonists.
EP1674087A1 (en) * 2000-10-02 2006-06-28 Pfizer Products Inc. Prophylactic use of n-methyl-d-aspartate (NMDA) antagonists
US20040204341A1 (en) * 2001-06-12 2004-10-14 Christopher Allen Nr2b receptor antagonists for the treatment or prevention of migraines
US8084447B2 (en) 2001-09-03 2011-12-27 Newron Pharmaceuticals S.P.A. Pharmaceutical composition comprising gabapentin or an analogue thereof and an α-aminoamide and its analgesic use
AU2003234395B2 (en) * 2002-05-13 2008-01-24 Endo Pharmaceuticals Inc. Abuse-resistant opioid solid dosage form
JP2006500395A (ja) * 2002-09-09 2006-01-05 エンド ファーマシューティカルズ インコーポレーテッド 組み合わされた即時放出及び徐放の鎮痛組成物
US6864271B2 (en) * 2002-11-12 2005-03-08 The Foundation For The Lsu Health Sciences Center Synergistic combinations including N-acylated 4-hydroxyphenylamine derivatives
WO2005041963A1 (en) * 2003-10-21 2005-05-12 Arakis Ltd. The use of non-opiates for the potentation of opiates
BRPI0415643A (pt) * 2003-10-21 2006-12-12 Arakis Ltd uso de ifenprodil no tratamento de dor
AU2005224160A1 (en) * 2004-03-17 2005-09-29 Sosei R&D Ltd. The treatment of inflammatory disorders and pain using beta-aminoalcohols
KR20070007850A (ko) * 2004-04-29 2007-01-16 콜드웰 갤러, 인코포레이티드 국소용 메타돈 조성물 및 그의 사용 방법
CN106176584A (zh) * 2005-10-14 2016-12-07 詹森药业有限公司 用于静脉施用的替比法尼制剂
HUP0600809A3 (en) * 2006-10-27 2008-09-29 Richter Gedeon Nyrt New phenylsulfamoyl-benzamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them
HUP0600810A3 (en) * 2006-10-27 2008-09-29 Richter Gedeon Nyrt New sulfonamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them
HUP0600808A3 (en) * 2006-10-27 2008-09-29 Richter Gedeon Nyrt New benzamide derivatives as bradykinin antagonists, process for their preparation and pharmaceutical compositions containing them
AU2007360523A1 (en) * 2007-10-27 2009-04-30 Richter Gedeon Nyrt. New non-peptide derivatives as bradykinin B1 antagonists
KR20110038139A (ko) 2008-07-17 2011-04-13 메리얼 리미티드 폴리오르소에스테르 및 이의 제형의 안정성 강화 방법
US20110190347A1 (en) * 2008-08-21 2011-08-04 Richter Gedeon Nyrt. Methods for treating neuropathic pain
WO2010022304A1 (en) * 2008-08-21 2010-02-25 Forest Laboratories Holdings Limited Methods for treating cns disorders

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5733M (xx) 1966-09-27 1968-01-22
FR2534580A1 (fr) 1982-10-13 1984-04-20 Synthelabo Derives de phenyl-1 piperidino-2 propanol, leur preparation, et medicaments qui les contiennent
FR2628740B3 (fr) 1989-04-12 1990-01-19 Synthelabo Procede de preparation des enantiomeres du (chloro-4 phenyl)-1 (((fluoro-4 phenyl)methyl)-4 piperidyl-1)-2 ethanol
TW281670B (xx) 1993-09-02 1996-07-21 Hoffmann La Roche
US5489717A (en) * 1994-07-08 1996-02-06 Warner-Lambert Company Glutamate (NMDA) receptor antagonists
GB9520444D0 (en) 1995-10-06 1995-12-06 Pharmacia Spa Disubstituted piperidine derivatives
TW450807B (en) 1995-09-15 2001-08-21 Pfizer Pharmaceutical compositions for treating tinnitus comprising neuroprotective agents
AUPN605795A0 (en) * 1995-10-19 1995-11-09 F.H. Faulding & Co. Limited Analgesic pharmaceutical composition
ZA9610738B (en) * 1995-12-22 1997-06-24 Warner Lambert Co Subtype selective nmda receptor ligands and the use thereof

Also Published As

Publication number Publication date
GB9804885D0 (en) 1998-04-29
JP2002505287A (ja) 2002-02-19
US6538008B1 (en) 2003-03-25
AU3260099A (en) 1999-09-20
CA2321685A1 (en) 1999-09-10
EP1059923A1 (en) 2000-12-20
WO1999044610A1 (en) 1999-09-10

Similar Documents

Publication Publication Date Title
ZA991745B (en) Combination of a selective NMDA NR2B antagonist and an opioid analgesic.
AU3080499A (en) Analgesic combination comprising nmda receptor antagonists and narcotic analgesics
AP2002002617A0 (en) Tamper-resistant oral opioid agonist formulation
SG104919A1 (en) Method ot form, and structure of, a dual damascene interconnect device
HK1039963A1 (en) Il-2 selective agonists and antagonists
HK1060429A1 (en) A sensibility generator and the method thereof
HK1124339A1 (en) 20-keto-11beta-arylsteroids and their derivatives having agonist or antagonist hormonal activity 20--11-
HUP0100310A3 (en) A method of preventing abuse of opioid dosage forms
AU2001261144A1 (en) Ultrasonic dosage device and method
HUP0105043A2 (en) Medicinal formulations containing an opioid and an alpha-antagonist
HUP0101439A3 (en) Sustained-release preparation for a ii antagonist, production and use thereof
HUP0101411A3 (en) A pharmaceutical preparation comprising an angiotensin ii type 2 receptor agonist, and use thereof
AU2161599A (en) Pharmaceutical combination with analgesic activity, containing an adenosinergic agonist and a compound selected from opiates, benzodiazepines and nmda antagonists
HUP0101546A3 (en) Combination for the treatment of alcohol and drug dependence containing an opioid antagonist and a nmda receptor complex modulator
IL138576A0 (en) A novel interleukin-1 receptor antagonist and uses thereof
EP1190146A4 (en) SYSTEM AND METHOD FOR POST-WALL FRAMEWORK USING A COMBINED CONNECTION AND SPREADING DEVICE
PL356153A1 (en) Method and device for testing the integrity of a packet, especially a cigarette packet
AU7133098A (en) Kappa opioid agonists
EP1164994A4 (en) FAST DISPERSION DOSAGE OPIOID AGONISTS
ZA987810B (en) A combination of a selective 5HT1A antagonist and a selective h5-HT1B antagonist or partial agonist
AU6878298A (en) Peripherally selective kappa opioid agonists
HU0002979D0 (en) Estrogen agonists and antagonists for multiple indications
PL348808A1 (en) Analgesic regimen
ZA200203312B (en) Vasopressin antagonist formulation and process.
GB2376300B (en) Acoustic mixing and measurement systems and method