ZA966192B - Method for the production of thrombin - Google Patents

Method for the production of thrombin

Info

Publication number
ZA966192B
ZA966192B ZA966192A ZA966192A ZA966192B ZA 966192 B ZA966192 B ZA 966192B ZA 966192 A ZA966192 A ZA 966192A ZA 966192 A ZA966192 A ZA 966192A ZA 966192 B ZA966192 B ZA 966192B
Authority
ZA
South Africa
Prior art keywords
thrombin
prothrombin
production
containing material
contacted
Prior art date
Application number
ZA966192A
Inventor
Adrian Malcolm Oates
Malgorzata Kupczyk
Jerry Kanellos
Original Assignee
Csl Limtied
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Csl Limtied filed Critical Csl Limtied
Publication of ZA966192B publication Critical patent/ZA966192B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A method for the preparation of thrombin from a prothrombin-containing material is characterised in that the prothrombin-containing material is an activated prothrombin complex concentrate ActPCC fraction, which is contacted with divalent cations to convert the prothrombin to thrombin.
ZA966192A 1995-07-24 1996-07-22 Method for the production of thrombin ZA966192B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AUPN4369A AUPN436995A0 (en) 1995-07-24 1995-07-24 Method for the production of thrombin

Publications (1)

Publication Number Publication Date
ZA966192B true ZA966192B (en) 1997-03-17

Family

ID=3788704

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA966192A ZA966192B (en) 1995-07-24 1996-07-22 Method for the production of thrombin

Country Status (14)

Country Link
US (1) US6168938B1 (en)
EP (1) EP0846166B1 (en)
JP (1) JP3810439B2 (en)
KR (1) KR19990035874A (en)
AT (1) ATE374812T1 (en)
AU (2) AUPN436995A0 (en)
CA (1) CA2227883C (en)
DE (1) DE69637278D1 (en)
DK (1) DK0846166T3 (en)
ES (1) ES2294788T3 (en)
HK (1) HK1011549A1 (en)
NZ (1) NZ312625A (en)
WO (1) WO1997004081A1 (en)
ZA (1) ZA966192B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998057678A2 (en) * 1997-06-18 1998-12-23 Cohesion Technologies, Inc. Compositions containing thrombin and microfibrillar collagen
US6274090B1 (en) * 1998-08-05 2001-08-14 Thermogenesis Corp. Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby
SE1050124A1 (en) * 2010-02-08 2011-08-09 Linkoping Biocontrols Ab Stable solution

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1981002105A1 (en) 1980-01-28 1981-08-06 Baxter Travenol Lab Therapeutic compositions & methods for manufacture and use
EP0443724B1 (en) * 1990-02-20 1999-03-17 Baxter International Inc. Viral-safe purified human thrombin
DE4137996A1 (en) * 1991-11-19 1993-05-27 Behringwerke Ag METHOD FOR PRODUCING A VIRUS-SAFE THROMBINE CONCENTRATE
JPH07308190A (en) * 1994-05-18 1995-11-28 Green Cross Corp:The Production of thrombin

Also Published As

Publication number Publication date
AUPN436995A0 (en) 1995-08-17
EP0846166A4 (en) 2001-06-13
HK1011549A1 (en) 1999-07-16
JP3810439B2 (en) 2006-08-16
JPH11509101A (en) 1999-08-17
DE69637278D1 (en) 2007-11-15
CA2227883A1 (en) 1997-02-06
CA2227883C (en) 2007-05-08
DK0846166T3 (en) 2008-02-04
KR19990035874A (en) 1999-05-25
ATE374812T1 (en) 2007-10-15
US6168938B1 (en) 2001-01-02
WO1997004081A1 (en) 1997-02-06
NZ312625A (en) 1999-01-28
EP0846166A1 (en) 1998-06-10
AU695396B2 (en) 1998-08-13
ES2294788T3 (en) 2008-04-01
AU6409596A (en) 1997-02-18
EP0846166B1 (en) 2007-10-03

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