ZA948232B - Amine derivatives as calcium channel antagonists - Google Patents

Amine derivatives as calcium channel antagonists

Info

Publication number
ZA948232B
ZA948232B ZA948232A ZA948232A ZA948232B ZA 948232 B ZA948232 B ZA 948232B ZA 948232 A ZA948232 A ZA 948232A ZA 948232 A ZA948232 A ZA 948232A ZA 948232 B ZA948232 B ZA 948232B
Authority
ZA
South Africa
Prior art keywords
calcium channel
amine derivatives
channel antagonists
antagonists
amine
Prior art date
Application number
ZA948232A
Inventor
David Gwyn Cooper
Ronald Joseph King
Thomas Henry Brown
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of ZA948232B publication Critical patent/ZA948232B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA948232A 1993-10-22 1994-10-20 Amine derivatives as calcium channel antagonists ZA948232B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939321812A GB9321812D0 (en) 1993-10-22 1993-10-22 Pharmaceuticals

Publications (1)

Publication Number Publication Date
ZA948232B true ZA948232B (en) 1996-04-22

Family

ID=10743964

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA948232A ZA948232B (en) 1993-10-22 1994-10-20 Amine derivatives as calcium channel antagonists

Country Status (6)

Country Link
EP (1) EP0724578A1 (en)
JP (1) JPH09504014A (en)
AU (1) AU7855394A (en)
GB (1) GB9321812D0 (en)
WO (1) WO1995011240A1 (en)
ZA (1) ZA948232B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE294778T1 (en) * 1995-01-23 2005-05-15 Daiichi Suntory Pharma Co Ltd IMPROVEMENT OR CURE OF SYMPTOMS CAUSED BY ISCHEMIC DISEASES AND PHENYLPIPERIDINE COMPOUNDS USABLE THEREFOR
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
WO1999043658A1 (en) 1998-02-27 1999-09-02 Warner-Lambert Company Heterocyclic substituted aniline calcium channel blockers
US6166052A (en) 1998-03-11 2000-12-26 Warner-Lambert Company Heteroaryl alkyl alpha substituted peptidylamine calcium channel blockers
WO2000021550A2 (en) * 1998-10-13 2000-04-20 President And Fellows Of Harvard College Methods and compositions for treating neurodegenerative diseases
JP4904948B2 (en) 2006-07-04 2012-03-28 住友化学株式会社 Method for producing intermediate alcohol compound
WO2016198691A1 (en) 2015-06-11 2016-12-15 Basilea Pharmaceutica Ag Efflux-pump inhibitors and therapeutic uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB560568A (en) * 1910-09-26 1944-04-11 Geigy Ag J R Manufacture of basic 1 : 3-dialkoxy-propanols and 1 : 3-dialkoxy-propanones
BE588558A (en) * 1959-03-13 1960-09-12
US3239520A (en) * 1961-11-20 1966-03-08 Nl Combinatie Chem Ind N-(monocarbocyclic aryloxy-lower alkyl)-n' (diloweralkyl, or heterocyclic)-lower alkylene diamines
US4518713A (en) * 1984-04-13 1985-05-21 Hoechst-Roussel Pharmaceuticals Inc. Analgesic substituted-1-aminoalkylamino-4-aryloxypiperidines
DE3418271A1 (en) * 1984-05-17 1985-11-21 Dr. Karl Thomae Gmbh, 7950 Biberach NEW BENZAZEPINE DERIVATIVES, MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
DK625886A (en) * 1986-07-25 1988-01-26 Cheminova As AMINOETHERS AND THEIR USE AS FUNGICIDES
DE59107813D1 (en) * 1990-12-19 1996-06-20 Kali Chemie Pharma Gmbh Alkylaminoalkylamine and ether compounds and processes and intermediates for their preparation and medicaments containing these compounds
GB9220735D0 (en) * 1992-10-02 1992-11-18 British Tech Group Heterocyclic amines

Also Published As

Publication number Publication date
WO1995011240A1 (en) 1995-04-27
AU7855394A (en) 1995-05-08
JPH09504014A (en) 1997-04-22
EP0724578A1 (en) 1996-08-07
GB9321812D0 (en) 1993-12-15

Similar Documents

Publication Publication Date Title
EG21556A (en) Bicyclic amine derivatives
ZA93550B (en) Azabricyclic compounds as calcium channel antagonists
GB9623944D0 (en) Bicyclic amine derivatives
AU7947594A (en) Substituted amides as tachykinin antagonists
HU9500897D0 (en) Amine modified epoxide-resin
GB9405317D0 (en) Fibrinogen receptor antagonists
AU3364493A (en) Compounds as calcium channel antagonists
LTIP1874A (en) Substituted azolone derivatives
HU9502028D0 (en) Fibrinogen receptor antagonists
AU2071095A (en) Substituted cycloalkylamine derivatives and their use as calcium channel antagonists
GB9420114D0 (en) Substituted cyclic derivatives as novel antidegenerative agents
GB9412605D0 (en) Amide derivatives
EP0708765A4 (en) Substituted piperazinylcamphor derivatives as oxytocin antagonists
ZA948232B (en) Amine derivatives as calcium channel antagonists
ZA93549B (en) Azabicyclo compounds as calcium channel antagonists
ZA948211B (en) Cyclic amine derivatives
GB9110722D0 (en) Amine derivatives
GB9311870D0 (en) Ties
GB9706222D0 (en) Bicyclic amine derivatives
GB9722959D0 (en) Bicyclic amine derivatives
ZA957746B (en) Carbamoyloxy amine compounds
AU2982595A (en) Benzocycloalkylamine derivatives as calcium chanel antagonists
AU6219594A (en) Calcium antagonist
GB9403729D0 (en) Amine derivatives
ZA939514B (en) Piperidine derivatives as calcium channel antagonists