ZA935648B - Method of enhancing differentiation and survival of neuronal precursor cells - Google Patents
Method of enhancing differentiation and survival of neuronal precursor cellsInfo
- Publication number
- ZA935648B ZA935648B ZA935648A ZA935648A ZA935648B ZA 935648 B ZA935648 B ZA 935648B ZA 935648 A ZA935648 A ZA 935648A ZA 935648 A ZA935648 A ZA 935648A ZA 935648 B ZA935648 B ZA 935648B
- Authority
- ZA
- South Africa
- Prior art keywords
- survival
- precursor cells
- neuronal precursor
- enhancing differentiation
- differentiation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0619—Neurons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Neurology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US92555692A | 1992-08-04 | 1992-08-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA935648B true ZA935648B (en) | 1994-08-29 |
Family
ID=25451901
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA935648A ZA935648B (en) | 1992-08-04 | 1993-08-04 | Method of enhancing differentiation and survival of neuronal precursor cells |
Country Status (4)
Country | Link |
---|---|
AU (1) | AU4995193A (en) |
IL (1) | IL106590A0 (en) |
WO (1) | WO1994003199A1 (en) |
ZA (1) | ZA935648B (en) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5981165A (en) * | 1991-07-08 | 1999-11-09 | Neurospheres Holdings Ltd. | In vitro induction of dopaminergic cells |
US7166277B1 (en) | 1991-07-08 | 2007-01-23 | Neurospheres Holdings Ltd. | Remyelination of neurons using multipotent neural stem cell progeny |
US5851832A (en) * | 1991-07-08 | 1998-12-22 | Neurospheres, Ltd. | In vitro growth and proliferation of multipotent neural stem cells and their progeny |
US5750376A (en) * | 1991-07-08 | 1998-05-12 | Neurospheres Holdings Ltd. | In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny |
US6071889A (en) * | 1991-07-08 | 2000-06-06 | Neurospheres Holdings Ltd. | In vivo genetic modification of growth factor-responsive neural precursor cells |
US5980885A (en) * | 1991-07-08 | 1999-11-09 | Neurospheres Holdings Ltd. | Growth factor-induced proliferation of neural precursor cells in vivo |
US6399369B1 (en) | 1991-07-08 | 2002-06-04 | Neurospheres Holdings Ltd. | Multipotent neural stem cell cDNA libraries |
US6294346B1 (en) | 1991-07-08 | 2001-09-25 | Neurospheres Holdings, Ltd. | Use of multipotent neural stem cells and their progeny for the screening of drugs and other biological agents |
US6497872B1 (en) | 1991-07-08 | 2002-12-24 | Neurospheres Holdings Ltd. | Neural transplantation using proliferated multipotent neural stem cells and their progeny |
US7361505B1 (en) | 1991-07-08 | 2008-04-22 | Neurospheres Holdings Ltd. | Multipotent neural stem cell compositions |
FR2717496B1 (en) * | 1994-03-18 | 1996-04-12 | Rhone Poulenc Rorer Sa | Recombinant viruses, preparation and use in gene therapy. |
ZA941729B (en) * | 1993-03-12 | 1994-10-13 | Max Planck Gesellschaft | Treatment of motor neuron diseases with fibroblast growth factor-5 (fgf-5). |
US5817485A (en) * | 1994-03-08 | 1998-10-06 | Human Genome Sciences, Inc. | Nucleic acids and cells for recombinant production of fibroblast growth factor-10 |
US5935849A (en) * | 1994-07-20 | 1999-08-10 | Cytotherapeutics, Inc. | Methods and compositions of growth control for cells encapsulated within bioartificial organs |
US5795790A (en) * | 1994-07-20 | 1998-08-18 | Cytotherapeutics, Inc. | Method for controlling proliferation and differentiation of cells encapsulated within bioartificial organs |
GB9422643D0 (en) * | 1994-11-08 | 1995-01-04 | Stringer Bradley M J | Neural cell lines |
AU716811B2 (en) * | 1994-11-14 | 2000-03-09 | Neurospheres Holdings Ltd | Regulation of neural stem cell proliferation |
GB9505663D0 (en) * | 1995-03-21 | 1995-05-10 | Stringer Bradley M J | Genetically modified neural cells |
AU750828B2 (en) * | 1995-03-21 | 2002-08-01 | Cellfactors Plc | Cell culture method |
WO1996033731A1 (en) * | 1995-04-26 | 1996-10-31 | Regeneron Pharmaceuticals, Inc. | Methods of using neurotrophic factors to enhance neuronal grafts |
US6495364B2 (en) | 1995-05-23 | 2002-12-17 | Neurotech, S.A. | Mx-1 conditionally immortalized cells |
US7544511B2 (en) | 1996-09-25 | 2009-06-09 | Neuralstem Biopharmaceuticals Ltd. | Stable neural stem cell line methods |
AU749530B2 (en) * | 1997-06-11 | 2002-06-27 | Acorda Therapeutics, Inc. | CNS neuroregenerative compositions and methods of use |
US6277820B1 (en) | 1998-04-09 | 2001-08-21 | Genentech, Inc. | Method of dopaminergic and serotonergic neuron formation from neuroprogenitor cells |
DE19837230A1 (en) * | 1998-08-17 | 2000-03-09 | Jean Krutmann | Use of neurotrophin-4 as a therapeutic agent, especially for treating melanoma |
US6667176B1 (en) | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
WO2001000662A2 (en) * | 1999-06-29 | 2001-01-04 | Eli Lilly And Company | The use of human fgh-8 polypeptides as neurotrophic agents |
US6749850B1 (en) | 1999-08-18 | 2004-06-15 | The General Hospital Corporation | Methods, compositions and kits for promoting recovery from damage to the central nervous system |
AU6790300A (en) * | 1999-08-18 | 2001-03-13 | Children's Medical Center Corporation | Methods, compositions and kits for promoting recovery from damage to the central nervous system |
US20050042749A1 (en) | 2001-05-16 | 2005-02-24 | Carpenter Melissa K. | Dopaminergic neurons and proliferation-competent precursor cells for treating Parkinson's disease |
US7250294B2 (en) | 2000-05-17 | 2007-07-31 | Geron Corporation | Screening small molecule drugs using neural cells differentiated from human embryonic stem cells |
GB2379447B (en) | 2000-05-17 | 2004-12-29 | Geron Corp | Neural progenitor cell populations |
AU2003213078A1 (en) | 2002-02-14 | 2003-09-04 | Buck Institute | Neurogenerative or neurotrophic factors for mitigating a symptom of ischemia |
US20040185429A1 (en) | 2002-12-09 | 2004-09-23 | Judith Kelleher-Andersson | Method for discovering neurogenic agents |
US8293488B2 (en) | 2002-12-09 | 2012-10-23 | Neuralstem, Inc. | Method for screening neurogenic agents |
EP3000877B1 (en) | 2004-06-09 | 2019-08-14 | The University Court of the University of Edinburgh | Neural stem cells |
EP2913393B8 (en) | 2004-11-17 | 2020-02-26 | Seneca Biopharma, Inc. | Transplantation of human neural cells for treatment of neurodegenerative conditions |
EP3187581A1 (en) | 2008-12-23 | 2017-07-05 | BOCO Silicon Valley, Inc. | Target populations of oligodendrocyte precursor cells and methods of making and using same |
CA2806904C (en) | 2010-07-28 | 2018-11-27 | Neuralstem, Inc. | Methods for treating and/or reversing neurodegenerative diseases and/or disorders |
KR102100021B1 (en) | 2014-10-20 | 2020-04-13 | 뉴럴스템, 인크. | Stable neural stem cells comprising an exogenous polynucleotide coding for a growth factor and methods of use thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990005138A1 (en) * | 1988-11-08 | 1990-05-17 | The Children's Medical Center Corporation | Cytotoxic amyloid precursors and screening assays using them |
US5229500A (en) * | 1989-08-30 | 1993-07-20 | Regeneron Pharmaceuticals, Inc. | Brain derived neurotrophic factor |
IE903130A1 (en) * | 1989-09-15 | 1991-03-27 | Regeneron Pharma | Ciliary neurotrophic factor |
-
1993
- 1993-07-30 WO PCT/US1993/007167 patent/WO1994003199A1/en active Application Filing
- 1993-07-30 AU AU49951/93A patent/AU4995193A/en not_active Abandoned
- 1993-08-04 IL IL106590A patent/IL106590A0/en unknown
- 1993-08-04 ZA ZA935648A patent/ZA935648B/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU4995193A (en) | 1994-03-03 |
WO1994003199A1 (en) | 1994-02-17 |
IL106590A0 (en) | 1993-12-08 |
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