ZA928258B - Phosphorous dirivatives, processes for their preparation and their use as collagenase inhibitors - Google Patents

Phosphorous dirivatives, processes for their preparation and their use as collagenase inhibitors

Info

Publication number
ZA928258B
ZA928258B ZA928258A ZA928258A ZA928258B ZA 928258 B ZA928258 B ZA 928258B ZA 928258 A ZA928258 A ZA 928258A ZA 928258 A ZA928258 A ZA 928258A ZA 928258 B ZA928258 B ZA 928258B
Authority
ZA
South Africa
Prior art keywords
dirivatives
phosphorous
processes
preparation
collagenase inhibitors
Prior art date
Application number
ZA928258A
Inventor
David James Hunter
Roger Edward Markwell
Robert William Ward
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of ZA928258B publication Critical patent/ZA928258B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA928258A 1991-10-28 1992-10-26 Phosphorous dirivatives, processes for their preparation and their use as collagenase inhibitors ZA928258B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919122859A GB9122859D0 (en) 1991-10-28 1991-10-28 Novel compounds

Publications (1)

Publication Number Publication Date
ZA928258B true ZA928258B (en) 1994-04-26

Family

ID=10703654

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA928258A ZA928258B (en) 1991-10-28 1992-10-26 Phosphorous dirivatives, processes for their preparation and their use as collagenase inhibitors

Country Status (10)

Country Link
EP (1) EP0612324A1 (en)
JP (1) JPH07500600A (en)
AU (1) AU2783492A (en)
CA (1) CA2122147A1 (en)
GB (1) GB9122859D0 (en)
MX (1) MX9206191A (en)
PT (1) PT101010A (en)
TW (1) TW234127B (en)
WO (1) WO1993009136A1 (en)
ZA (1) ZA928258B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6013792A (en) * 1993-08-05 2000-01-11 Syntex (U.S.A.), Inc. Matrix metalloprotease inhibitors
JPH09501430A (en) * 1993-08-05 1997-02-10 シンテックス（ユー・エス・エイ）・インコーポレイテッド Matrix metalloprotease inhibitor
US5773428A (en) * 1993-08-05 1998-06-30 Syntex (U.S.A.) Inc. Matrix metalloprotease inhibitors
US5831004A (en) * 1994-10-27 1998-11-03 Affymax Technologies N.V. Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use
US5840698A (en) * 1994-10-27 1998-11-24 Affymax Technologies N.V. Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use
DK2124562T3 (en) 2007-03-09 2016-08-01 Second Genome Inc BICYCLOHETEROARYLFORBINDELSER AS P2X7 modulators and uses thereof
CA2733390A1 (en) * 2008-08-01 2010-02-04 Bioxiness Pharmaceuticals, Inc. Methionine analogs and methods of using same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8726714D0 (en) * 1987-11-14 1987-12-16 Beecham Group Plc Compounds
EP0401963A1 (en) * 1989-04-13 1990-12-12 Beecham Group p.l.c. Phosphonopeptides with collagenase inhibiting activity
GB9008065D0 (en) * 1990-04-10 1990-06-06 Beecham Group Plc Novel compounds
GB9008078D0 (en) * 1990-04-10 1990-06-06 Beecham Group Plc Novel compounds

Also Published As

Publication number Publication date
EP0612324A1 (en) 1994-08-31
GB9122859D0 (en) 1991-12-11
JPH07500600A (en) 1995-01-19
CA2122147A1 (en) 1993-05-13
TW234127B (en) 1994-11-11
PT101010A (en) 1994-01-31
AU2783492A (en) 1993-06-07
MX9206191A (en) 1993-06-01
WO1993009136A1 (en) 1993-05-13

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