ZA913435B - Aqueous pharmaceutical formulations of erythropoietin and the use thereof - Google Patents

Aqueous pharmaceutical formulations of erythropoietin and the use thereof

Info

Publication number
ZA913435B
ZA913435B ZA913435A ZA913435A ZA913435B ZA 913435 B ZA913435 B ZA 913435B ZA 913435 A ZA913435 A ZA 913435A ZA 913435 A ZA913435 A ZA 913435A ZA 913435 B ZA913435 B ZA 913435B
Authority
ZA
South Africa
Prior art keywords
erythropoietin
aqueous pharmaceutical
pharmaceutical formulations
physiologically tolerated
epo
Prior art date
Application number
ZA913435A
Inventor
Dieter Brazel
Brazel Dieter
Thomas Brune
Brune Thomas
Bernhard Siebold
Siebold Bernhard
Dorothee Krumwieh
Krumwieh Dorothee
Original Assignee
Behringwerke Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke Ag filed Critical Behringwerke Ag
Publication of ZA913435B publication Critical patent/ZA913435B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Abstract

Aqueous pharmaceutical formulations of proteins with erythropoietin action, especially of natural human and recombinant human erythropoietin (EPO), are described. Highly purified EPO without foreign proteins or other conventional stabilisers retains at least about 78 % of its original activity at room temperature for at least 1 year in a physiologically tolerated aqueous phosphate buffer which contains a physiologically tolerated alkali metal halide but no other stabilising additives and has a pH of 6 to 8. The products in this aqueous pharmaceutical formulation are particularly suitable for subcutaneous or intramuscular administration.
ZA913435A 1990-05-08 1991-05-07 Aqueous pharmaceutical formulations of erythropoietin and the use thereof ZA913435B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4014654A DE4014654A1 (en) 1990-05-08 1990-05-08 GALENIC AQUEOUS FORMULATIONS OF ERYTHROPOIETIN AND THEIR USE

Publications (1)

Publication Number Publication Date
ZA913435B true ZA913435B (en) 1992-02-26

Family

ID=6405907

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA913435A ZA913435B (en) 1990-05-08 1991-05-07 Aqueous pharmaceutical formulations of erythropoietin and the use thereof

Country Status (13)

Country Link
EP (1) EP0456153B1 (en)
JP (1) JP2922331B2 (en)
KR (1) KR100203546B1 (en)
AT (1) ATE120646T1 (en)
AU (1) AU652361B2 (en)
CA (1) CA2041989C (en)
DE (2) DE4014654A1 (en)
DK (1) DK0456153T3 (en)
ES (1) ES2073063T3 (en)
IE (1) IE65925B1 (en)
NO (1) NO301805B1 (en)
PT (1) PT97584B (en)
ZA (1) ZA913435B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9917606A (en) * 1998-11-06 2002-12-31 Bio Sidus S A Procedure for the purification of recombinant human erythropoietin from cell culture supernatants and recombinant human erythropoietin obtained with such procedure
WO2001087329A1 (en) 2000-05-15 2001-11-22 F. Hoffmann-La Roche Ag Liquid pharmaceutical composition containing an erythropoietin derivate
DE10234192B4 (en) 2002-07-26 2009-11-26 Epoplus Gmbh Co.Kg Use of erythropoietin
EP1537876A1 (en) 2003-12-01 2005-06-08 BioGeneriX AG Erythropoietin solution formulation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57149228A (en) * 1981-03-11 1982-09-14 Ajinomoto Co Inc Novel erythropoietin and its preparation
JPH0686480B2 (en) * 1983-02-21 1994-11-02 雪印乳業株式会社 Monoclonal antibody for erythropoietin production
JPS6191131A (en) * 1984-10-09 1986-05-09 Chugai Pharmaceut Co Ltd Method and composition for preventing adsorption of pharmaceutical
JPS6197229A (en) * 1984-10-18 1986-05-15 Chugai Pharmaceut Co Ltd Stable erythropoietin preparation
DE3729863A1 (en) * 1987-09-05 1989-03-16 Boehringer Mannheim Gmbh STABILIZED ERYTHROPOIETIN LYOPHILISATES

Also Published As

Publication number Publication date
DE4014654A1 (en) 1991-11-14
DE59105075D1 (en) 1995-05-11
KR100203546B1 (en) 1999-06-15
ES2073063T3 (en) 1995-08-01
AU7618391A (en) 1991-11-14
PT97584B (en) 1998-08-31
CA2041989A1 (en) 1991-11-09
EP0456153B1 (en) 1995-04-05
IE65925B1 (en) 1995-11-29
KR910019636A (en) 1991-12-19
IE911549A1 (en) 1991-11-20
JPH04225923A (en) 1992-08-14
NO911788L (en) 1991-11-11
CA2041989C (en) 2001-07-31
PT97584A (en) 1992-01-31
DK0456153T3 (en) 1995-08-07
NO301805B1 (en) 1997-12-15
ATE120646T1 (en) 1995-04-15
AU652361B2 (en) 1994-08-25
NO911788D0 (en) 1991-05-07
JP2922331B2 (en) 1999-07-19
EP0456153A1 (en) 1991-11-13

Similar Documents

Publication Publication Date Title
UA26855C2 (en) Pharmaceutical composition regulating hematopoiesis
CA2113995A1 (en) Use of gentisic acid or gentisyl alcohol for stabilising radiolabeled peptides and proteins
FI945549A0 (en) Purified forms of deoxyribonuclease
GR3005326T3 (en)
BR9709844A (en) Aqueous preparation of insulin parenteral pharmaceutical formulation uses of a non-reducing or reduced carbohydrate and mannitol sorbitol xylitol inositol trehalose sucrose or any mixture and process for making an insulin preparation
ATE138099T1 (en) NON-GLYCOSATED PROTEINS, ANALOGUES OF HUMAN INTERLEUKIN-3
BR9709845A (en) Aqueous preparation of insulin parenteral pharmaceutical formulation and process to increase the chemical stability of an insulin preparation
GR3007107T3 (en)
ATE355850T1 (en) LYOPHILIZED HGF PREPARATIONS
GR3006815T3 (en)
DK0759775T3 (en) Liquid IFN beta formulations
AU652988B2 (en) Method for insuring adequate intracellular glutathione in tissue
ZA913435B (en) Aqueous pharmaceutical formulations of erythropoietin and the use thereof
AU3902489A (en) Non-glycosylated, recombinant human IL2 in the reduced form, the process for obtaining it and its use as a medicament
MY106615A (en) Stabilized leukocyte-interferons.
DE59005128D1 (en) t-PA per STABILIZATION.
ATE65396T1 (en) USE OF CARBON ACID IN PHARMACEUTICAL PREPARATIONS INTENDED FOR TOPICAL APPLICATION.
GR77250B (en)